Claims
- 1. A compound of formula (I) or a pharmaceutically acceptable salt thereof; ##STR57## wherein R.sup.1 is hydrogen, halo, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, nitrile, optionally protected carboxy, optionally protected tetrazolyl, trihalomethyl, hydroxy-C.sub.1-4 alkyl, aldehydo, --CH.sub.2 Z, --CH.dbd.CH--Z or --CH.sub.2 CH.sub.2 Z, where Z is optionally protected carboxy or optionally protected tetrazolyl;
- R.sup.2 is halo, nitrile, an optionally protected acid group, C.sub.1-4 alkoxy-carbonyl, or --CONR.sup.7 R.sup.8 where R.sup.7 and R.sup.8 are each hydrogen or C.sub.1-4 alkyl;
- R.sup.3 and R.sup.4 are each hydrogen, C.sub.1-4 alkyl, optionally substituted phenyl, or C.sub.1-4 alkyl substituted by --CONR.sup.7 R.sup.8 or an optionally protected acid group;
- R.sup.5 is selected from the following three formulae: ##STR58## where R.sup.10 is hydrogen, C.sub.1-4 alkyl, C.sub.2-6 alkenyl, C.sub.3-6 cycloalkyl or C.sub.1-4 alkyl-C.sub.3-6 cycloalkyl; R.sup.6 is hydrogen or C.sub.1-4 alkyl;
- each X is independently selected from, --O--(CH.sub.2).sub.n --CR.sup.11 R.sup.12 --, --S--(CH.sub.2).sub.n --CR.sup.11 R.sup.12 --, --CR.sup.11 R.sup.12 --, --CR.sup.11 R.sup.12 --(CH.sub.2).sub.n --CR.sup.13 R.sup.14 -- or --CR.sup.11 .dbd.CR.sup.12 --, where R.sup.11,R.sup.12,R.sup.13 and R.sup.14 are each hydrogen or C.sub.1-4 alkyl;
- n is 0, 1 or 2; and
- Y is --O--CR.sup.15 R.sup.16 --, --S--CR.sup.15 R.sup.16 --, --CR.sup.15 .dbd.CR.sup.16 -- or --CR.sup.15 R.sup.16 --CR.sup.17 R.sup.18 -- where R.sup.15, R.sup.16, R.sup.17 and R.sup.18 are each hydrogen or C.sub.1-4 alkyl.
- 2. The compound of claim 1 wherein R.sup.1 is selected from hydrogen or halogen.
- 3. The compound of claim 1 wherein the R.sup.2 is an acid group selected from tetrazolyl and carboxy.
- 4. The compound of claim 1 wherein R.sup.3 and R.sup.4 are selected from the groups (i), (ii) or (iii) where;
- (i) R.sup.3 and R.sup.4 are independently selected from hydrogen, C.sub.1-4 alkyl, and substituted phenyl;
- (ii) R.sup.3 and R.sup.4 are both hydrogen, R.sup.3 is hydrogen and R.sup.4 is C.sub.1-4 alkyl or optionally substituted phenyl, or R.sup.3 and R.sup.4 are each C.sub.1-4 alkyl; and
- (iii) R.sup.3 is C.sub.1-4 alkyl substituted by an acid group and R.sup.4 is hydrogen or C.sub.1-4 alkyl.
- 5. The compound of claim 1 wherein R.sup.6 is selected from hydrogen and C.sub.1-4 alkyl, with the proviso that when R.sup.6 is C.sub.1-4 alkyl it is attached at the 3-position.
- 6. The compound of claim 1 wherein X is --O--CR.sup.11 R.sup.12 -- or CR.sup.11 R.sup.12 --CR.sup.13 R.sup.14 --, and R.sup.11, R.sup.12, R.sup.13 and R.sup.14 are hydrogen.
- 7. The compound of claim 1 wherein linking group Y is --O--CR.sup.15 R.sup.16 -- or --CR.sup.15 .dbd.CR.sup.16 --, and R.sup.15, R.sup.16, R.sup.17 and R.sup.18 are hydrogen.
Parent Case Info
This application is a division of application Ser. No. 08/166,489, filed Dec. 14, 1993, U.S. Pat. No. 5,486,612.
Foreign Referenced Citations (1)
Number |
Date |
Country |
0 469 833 |
Jul 1991 |
EPX |
Divisions (1)
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Number |
Date |
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Parent |
166489 |
Dec 1993 |
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