Claims
- 1. A compound N-(6-p-Chlorophenoxyhexyl)-N'-cyano-N"-4-pyridylguanidine, and pharmaceutically acceptable, non-toxic salts and N-oxides thereof.
- 2. A method of treating a host to obtain a serotonin (5HT) antagonist effect therein which comprises administering to a host in need of such treatment, an effective amount of a compound according to claim 1.
- 3. A method according to claim 2 for the treatment of asthma, allergy, CNS disorders, or cancer.
- 4. A pharmaceutical composition comprising, as active ingredient, a compound according to claim 1 and a pharmaceutically acceptable carrier therefor.
- 5. A method of treating a host to obtain a serotonin (5HT) antagonist effect therein which comprises administering to a host in need of such treatment, an effective amount of a compound according to claim 4.
- 6. A method according to claim 5 for the treatment of asthma, allergy, CNS disorders, or cancer.
- 7. A method of treatment which comprises administering to a host in need of treatment of cancer, an effective amount of a compound of the formula (I) ##STR10## or their tautomeric forms, the attachment to the pyridine ring being in the 3- or 4-position, in which R', R" are the same or different and stand for hydrogen, halogen, or trifluoromethyl, hydroxy, C.sub.1 -C.sub.4 alkyl or alkoxy, nitro, or cyano groups; alkylene stands for a straight or branched C.sub.1 -C.sub.8 carbon chain, which may be substituted by hydroxy or halogen, nitro or cyano groups; X stands for oxygen, for --S(O).sub.n -- where n stands for an integer from 0 to 2, or for ##STR11## where R.sub.1 is hydrogen or C.sub.1 -C.sub.4 alkyl; R stands for hydrogen or for one or more C.sub.1 -C.sub.4 alkyl or alkoxy, hydroxy, halogen, trifluoromethyl, cyano, carboxamido, sulfamoyl or nitro radicals; their N-oxides; or pharmaceutically acceptable, non-toxic salts thereof.
- 8. A method of cancer treatment according to claim 7, wherein the compound is selected from the group consisting of N-Cyano-N'-(3-phenoxypropyl)-N"-4-pyridylguanidine, N-Cyano-N'-(4-phenoxybutyl)-N"-4-pyridylguanidine, N-Cyano-N'-(5-phenoxypentyl)-N"-4-pyridylguanidine, N-(6-p-Chlorophenoxyhexyl)-N'-cyano-N"-4-pyridylguanidine, and pharmaceutically acceptable, non-toxic salts and N-oxides thereof.
Priority Claims (1)
Number |
Date |
Country |
Kind |
9219472 |
Sep 1992 |
GBX |
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Parent Case Info
This is a continuation-in-part of National application Ser. No. 08/397,266 filed Mar. 15, 1995, now U.S. Pat. No. 5,563,160.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5563160 |
Bramm et al. |
Oct 1996 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
397266 |
Mar 1995 |
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