Claims
- 1. A compound of the formula: ##STR34## or a pharmacologically acceptable salt thereof wherein Het is of the formula: ##STR35## wherein A is of the formula: ##STR36## wherein R.sub.1 and R.sub.2 can be the same or different and each represents hydrogen, halogen, hydroxy, trifluoromethyl, alkoxy containing 1 to 7 carbon atoms
- R.sub.3 represents hydrogen, halogen or alkyl containing 1 to 7 carbon atoms;
- R.sub.4 represents hydrogen or alkyl containing 1 to 7 carbon atoms d is 0. 1 or 2 and e is 2 or 3 when A is of formula and d is 1 or 2 and e is 2 or 3 when A is of formula 2.
- 2. A compound according to claim 1 wherein A is ##STR37##
- 3. A compound according to claim 2 wherein Het is: ##STR38##
- 4. N-cyano-N'-[2-(((5-methyl-1H-imidazol-4-yl)methyl)(thio)ethyl]-N"-[3-(5-(2-aminopyrimidinyl)) 2-propen- 1-yl] guanidine or pharmaceutically acceptable salt thereof.
- 5. N-cyano-N'[2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl]-N"-[3-(5-pyrimidinyl)-2-propen-1-yl]guanidine or a pharmaceutically acceptable salt thereof.
Parent Case Info
This application is a continuation-in-part of application Ser. No. 172,341, filed 12/16/80 now abandoned which is a continuation-in-part of Ser. No. 101,923 filed 12/16/80 now U.S. Pat. No. 4,239,908.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4239769 |
Price et al. |
Dec 1980 |
|
4239908 |
Adelstein |
Dec 1980 |
|
Foreign Referenced Citations (2)
Number |
Date |
Country |
857388 |
Feb 1978 |
BEX |
867594 |
Nov 1978 |
BEX |
Non-Patent Literature Citations (3)
Entry |
Gensler et al., J.A.C.S. vol. 77, p. 3262, 1955. |
Meyers, J. Org. Chem. vol. 46, p. 3119, 1981. |
Plevyak et al., J. Org. Chem. vol. 44, p. 4078, 1979. |
Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
172341 |
Dec 1980 |
|
Parent |
101923 |
Dec 1980 |
|