Fry, Lionel, “Psoriasis: Immunopathology and Long-term treatment with Cyclosporin,” J. of Autoimmunity, 1992, 5, 277-283. |
Ponticelli, Claudio et al., “Treatment of the Nephrotic Syndrome with Cyclosporin A,” J. of Autoimmunity, 1992, 5, 315-324. |
Tindall, Richard S.A., “Immunointervention with Cyclosporin A in autoimmune Neurological Disorders,” J. of Autoimmunity, 1992, 5, 301-313. |
Tugwell, Peter, “Cyclosporin in the Treatment of Rheomatoid Arthritis,” J. of Autoimmunity, 1992, 5, 231-240. |
Dragovich et al., “Structure-Based Design of Novel, Urea-containing FKBP-12 Inhibitors,” J. Med. Chem., 1996, 39, 1872-1884. |
Gold et al., “The Immunosuppressant FK506 Increases the Rate of Axonal Regeneration in Rat Sciatic Nerve,” J. Neurosci., 1995, 15(11), 7509-7516. |
Gold et al., “The Immunosuppressant FK506 increases functional recovery and nerve regeneration following peripheral nerve injury,” Restorative Neurology and Neuroscience, 1994, 6, 287-296. |
Lyons et al., “Immunosuppressant FK506 promotes neurite outgrowth in culture of PC12 cells and sensory ganglia,” Proc. Natl. Acad. Sci. USA, 1994, 91, 3191-3195. |
Gold et al., “Multiple signals underlie the anatomy-induced up-regulation of c-JUN in adult sensory neurons,”0 Neurosci. Lett., 1994, 176, 123-127. |
Gold et al., “Regulation of the transcription factor c-JUN by nerve growth factor in adult sensory neurons,” Neurosci. Lett., 1993, 154, 129-133. |
Sharkey et al., Chemical Abstracts, 121:221398, 1994. |
Kelly et al., Chemical Abstractsm 122:114965, 1994. |
Burbaum, Chemical Abstracts, vol. 123:170197, 950613. |
Burbaum, Chemical Abstracts, vol. 121:109686, 940607. |
Armistead, Chemical Abstracts, vol. 121:170549, 940719. |
Armistead, Chemical Abstracts, vol. 117:131071, 920109. |
Holt, Chemical Abstracts, vol. 125:86501, 960229. |
Smith, Chemical Abstracts, vol. 125:114400, 960613. |
Baker, Chemical Abstracts, vol. 123:313433, 950511. |
Camaggi, Chemical Abstracts, vol. 124:30417, 950510. |
Armistead, Chemical Abstracts, vol. 122:55896, 940414. |
Skotnicki, Chemical Abstracts, vol. 120:54388, 931012. |
Luethy, Chemical Abstracts, vol. 123:313999, 930428. |
Frenette, Chemical Abstracts, vol. 121:35325, 931223. |
Krantz, Chemical Abstracts, vol. 120:245776, 930708. |
Ito, Chemical Abstracts, vol. 120:245780, 930720. |
Casini, Chemical Abstracts, vol. 120:270095, 93. |
Armistead, Chemical Abstracts, vol. 119:95338, 921112. |
Goulet, Chemical Abstracts, vol. 118:80723, 92015. |
Kasahara, Chemical Abstract, vol. 117:48221, 920304. |
Long, Chemical Abstract, vol. 118:169119, 921029. |
Schreiber, Chemical Abstracts, vol. 123:275997, 950905. |
Rinehart, Chemical Abstracts, vol. 121:887, 940315. |
Takeuchi, Chemical Abstracts, vol. 122:131140, 941025. |
Thaisrivongs, Chemical Abstracts, vol. 117:112083, 920305. |
Yamada, Chemical Abstracts, vol. 117:212981, 920522. |
Someno, Chemical Abstracts, vol. 116:236174, 920129. |
Schreiber, Chemical Abstracts, vol. 116:34554, 910905. |
Rinehart, Chemical Abstracts, vol. 115:248086, 910418. |
Baader, Chemical Abstracts, vol. 116:129617, 911114. |
Prasit, Chemical Abstracts, vol. 115:207870, 910327. |
Askin, Chemical Abstracts, vol. 114:228633, 910102. |
Jones, Chemical Abstracts, vol. 114:81436, 900718. |
Takeuchi, Chemical Abstracts, vol. 115:90647, 901101. |
Dreyer, Chemical Abstracts, vol. 113:153045, 900124. |
Bieringer, Chemical Abstracts, vol. 113:226420, 900329. |
Askin, Chemical Abstracts, vol. 114:23615, 1990. |
Goulet, Chemical Abstracts, vol. 114:81347, 1990. |
Jones, Chemical Abstracts, vol. 112:235036, 1990. |
Jones, Chemical Abstracts, vol. 113:23463, 1990. |
Hauske, James R. et al., “Design and Synthesis of Novel FKBP Inhibitors,” J. Med. Chem., 1992, 35, 4284-4296. |
Holt, Dennis A. et al., “Structure-Activity Studies of Nonmacrocyclic Rapamycin Derivatives,” Bioorganic & Medicinal Chemistry Letters, 1993, 3(10), 1977-1980. |
Yamashita, Dennis S. et al., “Design Synthesis and Evaluation of Dual Domain FKBP Ligands,” Bioorg. Med. Chem. Lett., 1994, 4(2), 325-328. |
Teague, Simon J. et al., “Synthesis and Study of a Non-Macrocyclic FK506 Derivative,” Bioorg. Med. Chem. Lett., 1994, 4(13), 1581-1584. |
Luengo, Juan I. et al., “Synthesis and Structure-Activity Relationships of Macrocyclic FKBP Ligands,” Bioorg. Med. Chem. Lett., 1994, 4(2), 321-324. |
Holt, Dennis A. et al., “Structure-Activity Studies of Synthetic FKBP Ligands as Peptidyl-Prolyl Isomerase Inhibitors,” Bioorg. Med. Chem. Lett., 1994, 4(2) 315-320. |
Teague, Simon J. et al., “The Affinity of the Excised Binding Domain of FK-506 for the Immunophilin FKBP12,” Bioorg. Med. Chem. Lett., 1993, 3(10), 1947-1950. |
Caffrey, Moya V. et al., “Synthesis and Evaluation of Dual Domain Macrocyclic FKBP12 Ligands,” Bioorg. Med. Chem. Lett., 1994, 4(21), 2507-2510. |
Birkenshaw, Timothy N. et al., “Synthetic FKBP12 Ligands. Design and Synthesis of Pyranose Replacements,” Bioorg. Med. Chem. Lett., 1994, 4(21), 2501-2506. |
Holt, Dennis A. et al., “Design, Synthesis, and Kinetic Evaluation of High-Affinity FKBP Ligands and the X-ray Crystal Structures of Their Complexes with FKBP12,” J. Am. Chem. Soc., 1993, 115, 9925-9938. |
Wang, Gary T. et al., “Synthesis and FKBP Binding of Small Molecule Mimics of the Tricarbonyl Region of FK506,” Bioorg. Med. Chem. Lett., 1994, 4(9), 1161-1166. |
Snyder, Solomon H. et al., “Immunophilins and the Nervous System,” Nature Medicine, 1995 1(1), 32-37. |
Stocks, Michael J. et al., “The Contribution to Binding of the Pyranoside Substituents in the Excised Binding Domain of FK-506,” Bioorg. Med. Chem. Lett., 1994, 4(12), 1457-1460. |
Kino, Toru et al., “FK-506, A novel immunosuppressant isolated from A Streptomyces,” J. of Antibiotics, 1987, 40(9), 1249-1255. |
Goulet, Mark T. et al., “Degradative Studies on the tricarbonyl containing macrolide rapamycin,” Tetrahedron Lett., 1990, 31(34), 4845-4848. |
Ando, Takao et al., “Formation of Crossed Phenzine from the Reaction between Tetra-p-anisyl- and Tetra-p-tolyl-hydrazines in Liquid Sulphur Dioxide,” Chem. Comm., 1975, 989. |
Whitesell, J.K. et al., “Asymmetric Induction. Reduction, Nucleophilic Addition to, Ene Reactions of Chiral α-Ketoesters,” J. Chem. Soc., Chem. Commun., 1983, 802. |
Rao, A.V. et al., “Studies directed towards the synthesis of immunosuppressive agent FK-506: construction of the tricarbonyl moiety,” Tetrahedron Lett., 1990, 31(10), 1439-1442. |
Harding, M.W. et al., “A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase,” Nature Lett., 1989, 341, 758-60. |
Finberg, Robert W. et al., “Prevention of HIV-1 Infection and Preservation of CD4 Function by the Binding of CPFs to gp120,” Science, 1990, 249, 287-291. |
Hayward, C.M. et al., “An application of the Suarez reaction to the regiospecific synthesis of the C28-C42 segment of rapamycin,” 3989-3992. |
Dawson, T.M. et al., “The Immunophilins, FK506 binding and cyclophilin, are discretely localized in the brain: relationship to calcineurin,” Neuroscience, 1994, 62(2), 569-580. |
Wasserman, H.H. et al., “Synthesis of the tricarbonyl region of FK-506 through an amidosphere,” J. Org. Chem., 1989, 54(12), 2785-6. |
Hovarth, R. et al., “An application of the Evans-Prasad 1,3-Syn diol synthesis to a stereospecific synthesis of the C10-C27 segment of rapamycin,” Tetrahedron Lett., 1993, 34(25), 3993-3996. |
Coleman, R. et al., “Degradation and manipulations of the immunosuppressant FK506: preparation of potential synthetic intermediates,” Heterocycles, 1989, 28(1), 157-161. |
Cameron, Andrew et al., “Immunophilin FK506 binding protein associated with inositol 1,4,5-triphosphate receptor modulates calcium flux,” Proc. Natl. Acad. Sci. USA, 1995, 92, 1784-1788. |
Boulmedais, Ali et al., “Stereochemistry of Electrochemical Reduction of Optically Active α-ketoamides. II. Electroreduction of benzoylformamides derived from S-(-)-proline,” Bull. Soc. Chim. Fr., 1989, 2, 185-191. (French). |
Stocks, M. et al., “The contribution to the binding of the pyranoside substituents in the excised binding domain of FK-506,” Bioorg. Med. Chem. Lett., 1994, 4(12), 1457-1460. |
Lyons, W. Ernest et al., “Neuronal Regeneration Enhances the Expression of the Immunophilin FKBP-12,” J. Neurosci., 1995, 15, 2985-2994. |
Egbertson, M. et al., “A synthetic route to the tricarbonyl region of FK-506,” J. Org. Chem., 1989, 54(1), 11-12. |
Williams, D.R. et al., “Synthesis of the α,β diketo amide segment of the novel immunosuppressive FK506,” J. Org. Chem., 1988, 53(191), 4643-4644. |
Kocienski, P. et al., “A synthesis of the C(1)-C(15) segment of tsukubaenolide (FK506),” Tetrahedron Lett., 1988, 29(35), 4481-4484. |
Tanaka, H. et al., “Structure of FK506, a novel immunosuppresssant isolated from Streptomyces,” J. Am. Chem. Soc., 1987, 109(16), 5031-5033. |
Steiner, J.P. et al., “Nonimmunosuppressive Ligands for Neuroimmunophilins Promote Nerve Extension In Vitro and In Vivo,” Society for Neuroscience Abstracts, 1996, 22, 297.13. |
Soai, Kenso et al., “Asymmetric synthesis of both eaniomers of α-hydroxy acids by the diastereoselective reduction of chiral α-keto amides with complex metal hydrides in the presence of a metal salt,” Chem. Lett., 1986, 11, 1897-900. |
Soai, Kenso et al., “Diastereoselective reduction of chiral α-ketoamides derived from (S)-proline esters with sodium borohydride. Preparation of optically active α-hydroxy acids,” J. Chem. Soc., 1985, 1(4), 769-772. |
Soai, Kenso et al., “Diastereoselective asymmetric allylation of chiral α-keto amides with allyltrimethylsilane. Preparation of protected homoallylic alcohols,” J. Chem. Soc., 1984, 15, 1016-1017. |
Caufield, Craig E. et al., Annual Reports in Medicinal Chemistry, Johns (Ed.), Academic Press, Inc., Chapter 21, 195-204, 1989. |
Bender, D. et al., “Periodate oxidation of α-keto γ-lactams. Enol oxidation and β-lactam formation. Mechanism of periodate hydroxylation reactions,” J. Org. Chem., 1978, 43(17), 3354-3362. |
Effenberger, F. et al., “Diastereoselective addition of benzenesulfenyl chloride to 1-acryloylproline esters,” Chemical Abstracts, 1989, 10, 778-779. |
Nakatsuta, M. et al., “Total Synthesis of FK506 and an FKBP Reagent, (C8, C9-13C2)-FK-506,” J. Am. Chem. Soc., 1990, 112(14), 5583-5590. |
Steiner, Joseph P. et al., “High brain densities of the immunophilin FKBP colocalized with calcineurin,” Nature Lett., 1992, 358, 584-7. |
Dawson, Ted. M. et al., “Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity,” Proc. Natl. Acad. Sci. USA, 1993, 90, 9808-9812. |
Blaschke et al., Chemical Abstracts, 1974, 85, 78405k. |
Bycroft, Barrie W. et al., “Efficient asymmetric synthesis of .alpha.-ketoacids an ammonia with conservation of the chiral reagent,” J. Chem. Soc., 1975, 24, 988-989. |
Kaczmar et al., Makromol. Chem., 1976, 77, 1981-1989. |
Holt, Dennis A. et al., “Structure-activity of synthetic FKBP ligands as peptidyl-prolyl isomerase inhibitors,” Bioorg. Med. Chem. Lett., 1994, 4(2), 315-320. |
Feutren, Gilles, “The Optimal Use of Cyclosporin A in Autoimmune Diseases,” J. of Autoimmunity, 1992, 5, 183-195. |
Rao, Chemical Abstracts, vol. 113:191007, 1990. |
Waldmann, Chemical Abstracts, vol. 114:82457, 1990. |
Finberg, Chemical Abstracts, vol. 113:184256, 1990. |
Gold, Chemical Abstracts, vol. 111:195414, 890404. |
Gold, Chemical Abstracts, vol. 111:97735, 890228. |
Matsuo, Chemical Abstracts, vol. 112:158977, 890920. |
Goodfellow, Chemical Abstracts, vol. 111:93084, 1989. |
Wasserman, Chemical Abstracts, vol. 112:35516, 1989. |
Wasserman, Chemical Abstracts, vol. 111:57366, 1989. |
Askin, Chemical Abstracts, vol. 111:232396, 1989. |
Faelth, Chemical Abstracts, vol. 112:97901, 1989. |
Boulmedais, Chemical Abstracts, vol. 112:44174, 1989. |
Coleman, Chemical Abstracts, vol. 112:7219, 1989. |
Egbertson, Chemical Abstracts, vol. 110:57371, 1989. |
De Luca, Chemical Abstracts, vol. 111:23387, 881215. |
Arzeno, Chemical Abstracts, vol. 110:8697, 880316. |
Williams, Chemical Abstracts, vol. 109:170092, 1988. |
Kocienski, Chemical Abstracts, vol. 110:212441, 1988. |
Tanaka, Chemical Abstracts, vol. 107:175741, 1987. |
Soai, Chemical Abstracts, vol. 108:38323, 1987. |
Munegumi, Chemical Abstracts, vol. 107:218023, 1987. |
Gavras, Chemical Abstracts, vol. 105:6828, 860304. |
Nestor, Chemical Abstracts, vol. 106:214389, 861008. |
Gante, Chemical Abstracts, vol. 107:97131, 860911. |
Soai, Chemical Abstracts, vol. 105:134309, 1986. |
Soai, Chemical Abstracts, vol. 107:197713, 1986. |
Soai, Chemical Abstracts, vol. 103:70915, 1985. |
Soai, Chemical Abstracts, vol. 102:78344, 1984. |
Harris, Chemical Abstracts, vol. 99:88574, 830222. |
Smith, Chemical Abstracts, vol. 100:175294, 830914. |
Ryan, Chemical Abstracts, vol. 100:103897, 830302. |
Soai, Chemical Abstracts, vol. 99:105651, 1983. |
Neustadt, Chemical Abstracts, vol. 97:216730, 820505. |
Ryan, Chemical Abstracts, vol. 97:163506, 820324. |
Colombo, Chemical Abstracts, vol. 98:161133, 1982. |
Soai, Chemical Abstracts, vol. 98:88478, 1982. |
Patchett, Chemical Abstracts, vol. 95:25634, 800625. |
Bender, Chemical Abstracts, vol. 89:128811, 1978, |
Steglich, Chemical Abstracts, vol. 89:214864, 1978. |
Cushman, Chemical Abstracts, vol. 88:18091, 1977. |
Steglich, Chemical Abstracts, vol. 85:108966, 1976. |
Bycroft, Chemical Abstracts, vol. 84:106021, 1975. |
Marshall, Chemical Abstracts, vol. 83:178991, 1975. |
Haeusler, Chemical Abstracts, vol. 80:108833, 1974. |
Hearn, Chemical Abstracts, vol. 68:22217, 1967. |
Chakraborty, Chemical Abstracts, vol. 125:115111, 1996. |
Shu, Chemical Abstracts, vol. 124:342921, 1996. |
Chakraborty, Chemical Abstracts, vol. 124:290256, 1996. |
Slee, Chemical Abstracts, vol. 124:105570, 1995. |
Tatlock, Chemical Abstracts, vol. 124:86677, 1995. |
Teague, Chemical Abstracts, vol. 124:29474, 1995. |
Stocks, Chemical Abstracts, vol. 124:29735, 1995. |
Wang, Chemical Abstracts, vol. 123:275108, 1995. |
Nicolaou, Chemical Abstracts, vol. 123:285602, 1995. |
Armistead, Chemical Abstracts, vol. 123:217939, 1995. |
Luengo, Chemical Abstracts, vol. 123:187705, 1995. |
Furber, Chemical Abstracts, vol. 123:47577, 1995. |
Chakraborty, Chemical Abstracts, vol. 123:74408, 1995. |
Wang, Chemical Abstracts, vol. 123:74101, 1995. |
Smith, Chemical Abstracts, vol. 123:55541, 1995. |
Baumann, Chemical Abstracts, vol. 122:314327, 1995. |
Munoz, Chemical Abstrtacts, vol. 122:188156, 1994. |
Nelson, Chemical Abstracts, vol. 122:80964, 1994. |
Caffrey, Chemical Abstracts, vol. 123:82999, 1994. |
Birkenshaw, Chemical Abstracts, vol. 122:187213, 1994. |
Hauske, Chemical Abstracts, vol. 122:45705, 1994. |
Stocks, Chemical Abstracts, vol. 121:271263, 1994. |
Teague, Chemical Abstracts, vol. 121:255492, 1994. |
Mashkovskii, Chemical Abstracts, vol. 121:212542, 1993. |
Ranganathan, Chemical Abstracts, vol. 121:205990, 1994. |
Wang, Chemical Abstracts, vol. 121:170041, 1994. |
Baader, Chemical Abstracts, vol. 121:102790, 1994. |
Luengo, Chemical Abstracts, vol. 121:49600, 1994. |
Holt, Chemical Abstracts, vol. 121:224, 1994. |
Teague, Chemical Abstracts, vol. 121:215, 1993. |
Karle, Chemical Abstracts, vol. 120:324190, 1994. |
Skotnicki, Chemical Abstracts, vol. 120:323021, 1994. |
Skotnicki, Chemical Abstracts, vol. 120:323020, 1994. |
Holt, Chemical Abstracts, vol. 120:323019, 1993. |
Rao, Chemical Abstracts, vol. 120:323003, 1993. |
Yamashita, Chemical Abstracts, vol. 120:315168, 1994. |
Andrus, Chemical Abstracts, vol. 120:134101, 1993. |
Holt, Chemical Abstracts, vol. 120:134099, 1993. |
Luengo, Chemical Abstracts, vol. 120:54365, 1993. |
Steffan, Chemical Abstracts, vol. 120:54360, 1993. |
Nicolaou, Chemical Abstracts, vol. 119:278059, 1993. |
Hayward, Chemical Abstracts, vol. 119:249751, 1993. |
Pattenden, Chemical Abstracts, vol. 119:95189, 1993. |
Yohannes, Chemical Abstracts, vol. 119:49108, 1993. |
Furber, Chemical Abstracts, vol. 119:27877, 1993. |
Luengo, Chemical Abstracts, vol. 118:233723, 1993. |
Ranganathan, Chemical Abstracts, vol. 118:213513, 1993. |
Yohannes, Chemical Abstracts, vol. 118:147360, 1992. |
Hauske, Chemical Abstracts, vol. 118:22591, 1992. |
Cunliffe, Chemical Abstracts, vol. 117:49183, 1992. |
Goulet, Chemical Abstracts, vol. 116:193989, 1991. |
Waldmann, Chemical Abstracts, vol. 116:41997, 1991. |
Goulet, Chemical Abstracts, vol. 115:255882, 1991. |
Krit, Chemical Abstracts, vol. 115:232847, 1991. |
Rao, Chemical Abstracts, vol. 114:247016, 1991. |
Fisher, Chemical Abstracts, vol. 114:228608, 1991. |
Linde, Chemical Abstracts, vol. 114:206955, 1991. |