Claims
- 1. As an antischistosomal agent, a compound having the structure ##SPC2##
- wherein R represents a radical selected from the group consisting of methoxybenzyl, dimethoxybenzyl, pyridylmethyl, N,N-dimethylaminobenzyl and phenoxypropyl, or the pharmaceutically acceptable acid addition salts thereof.
- 2. The antischistosomal agent of claim 1 which is 1-(2,3-dimethoxybenzyl)-2-(5-nitro-2-furyl)vinyl]imidazole, or the pharmaceutically acceptable acid addition salts thereof.
- 3. The antischistosomal agent of claim 1 which is 1-(3,4-dimethoxybenzyl)-2-[2-(5-nitro-2-furyl)vinyl]imidazole, or the pharmaceutically acceptable acid addition salts thereof.
- 4. The antischistosomal agent of claim 1 which is 1-(3-methoxybenzyl)-2-[2-(5-nitro-2-furyl)vinyl]imidazole, or the pharmaceutically acceptable acid addition salts thereof.
- 5. The antischistosomal agent of claim 1 which is 1-(4-N,N-dimethylaminobenzyl)-2-[2-(5-nitro-2-furyl)vinyl]imidazole, or the pharmaceutically acceptable acid addition salts thereof.
- 6. The antischistosomal agent of claim 1 which is 1-(4-picolyl)-2-[2-(5-nitro-2-furyl)vinyl]imidazole, or the pharmaceutically acceptable acid addition salts thereof.
- 7. The antischistosomal agent of claim 1 which is 1-(2-picolyl)-2-[2-(5-nitro-2-furyl)vinyl]imidazole, or the pharmaceutically acceptable acid addition salts thereof.
- 8. The antischistosomal agent of claim 1 which is 1-(phenoxypropyl)-2-[2-(5-nitro-2-furyl)vinyl]imidazole, or the pharmaceutically acceptable acid addition salts thereof.
- 9. The antischistosomal agent of claim 1 which is 1-(4-methoxybenzyl)-2-[2-(5-nitro-2-furyl)vinyl]imidazole, or the pharmaceutically acceptable acid addition salts thereof.
ORIGIN OF INVENTION
The invention described herein was made in the course of work under a grant or award from the National Institute of Health, Department of Health, Education, and Welfare.
Foreign Referenced Citations (2)
Number |
Date |
Country |
4,710,878 |
Mar 1972 |
JA |
4,211,829 |
Jul 1969 |
JA |
Non-Patent Literature Citations (2)
Entry |
Fujita et al., J. Pharm. Soc. Japan, 86, 1966, pp. 427-432. |
Henry et al., J. Med. Chem., 16, 1973, pp. 1287-1291. |