Claims
- 1. A method of regulating an immune response in a patient which comprises administering to the patient an immunomodulating effective amount of an aziridine derivative of the formula: ##STR12## wherein R.sub.1 is C.sub.1 -C.sub.4 alkoxy and R.sub.2 is hydroxymethyl, carboxyl, alkoxycarbonyl with 2 to 5 carbon atoms, a formyl or carbamoyl or a pharmacologically acceptable salt or a pyridine N-oxide thereof.
- 2. A method of suppressing an immune response in a patient which comprises administering to the patient an immunosuppressing effective amount of an aziridine derivative of the formula: ##STR13## wherein R.sub.1 is C.sub.1 -C.sub.4 alkoxy and R.sub.2 is hydroxymethyl, carboxyl, alkoxycarbonyl with 2 to 5 carbon atoms, formyl or carbamoyl or a pharmacologically acceptable salt or a pyridine N-oxide thereof.
- 3. Aziridine derivative compound of the formula: ##STR14## wherein R.sub.1 is C.sub.1 -C.sub.4 alkoxy and R.sub.2 is hydroxymethyl, carboxyl, alkoxycarbonyl with 2 to 5 carbon atoms, formyl or carbamoyl or a pharmacologically acceptable salt or a pyridine N-oxide thereof.
- 4. The compound of claim 3 wherein R.sub.2 is carboxyl, hydroxymethyl or formyl.
- 5. The compound of claim 3 wherein R.sub.1 is methoxy.
- 6. The compound of claim 3 designated 2-cyano-1-[(2-methoxy-6-carboxypyridine-3-yl)-methyl]-aziridine.
- 7. The compound of claim 3 designated 2-cyano-1-[(2-methoxy-6-hydroxymethylpyridine-3-yl)-methyl]-aziridine.
- 8. The compound of claim 3 designated 2-cyano-1-[(2-methoxy-6-formylpyridine-3-yl)-methyl]-aziridine.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3446713 |
Dec 1984 |
DEX |
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Parent Case Info
This application is a continuation-in-part of Ser. No. 804,156, filed Dec. 3, 1985, and now abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
4321194 |
Bosies et al. |
Mar 1982 |
|
4409236 |
Bosies et al. |
Oct 1983 |
|
4410532 |
Bosies et al. |
Oct 1983 |
|
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
804156 |
Dec 1985 |
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