Nanostructured Membrane for Implantable Glucose Sensors

Information

  • Research Project
  • 6803644
  • ApplicationId
    6803644
  • Core Project Number
    R43GM063287
  • Full Project Number
    5R43GM063287-02
  • Serial Number
    63287
  • FOA Number
    PA-02-25
  • Sub Project Id
  • Project Start Date
    9/26/2003 - 21 years ago
  • Project End Date
    8/31/2005 - 19 years ago
  • Program Officer Name
    LEWIS, CATHERINE D.
  • Budget Start Date
    9/1/2004 - 20 years ago
  • Budget End Date
    8/31/2005 - 19 years ago
  • Fiscal Year
    2004
  • Support Year
    2
  • Suffix
  • Award Notice Date
    9/6/2004 - 20 years ago
Organizations

Nanostructured Membrane for Implantable Glucose Sensors

DESCRIPTION (provided by applicant): Long-term implantable biosensors have been commercially unavailable because a common problem associated with biosensors is protein deposition and fibrous encapsulation known as biofouling limiting device lifetime. Implantable biosensors can benefit greatly from improving membrane and coating layer structures using functional materials on biomembrane surfaces that reduce protein adsorption and the subsequent inflammatory response. Inframat Corporation proposes to demonstrate the feasibility of a novel nanostructured membrane for implantable glucose sensors. The proposed nanostructured membrane is expected to control tissue/glucose sensor interface interactions, thereby reducing protein adsorption while increasing biocompatibility for the sensor. This will extend glucose sensor lifetime. The proposed program consists of preparing a protein-resistant nanostructured membrane, evaluating its physical properties, and confirming improved performance in-vitro for glucose sensor applications. This program is based on our extensive experience in nanotechnology, particularly in nanostructured materials and coatings. Inframat is collaborating with Dr. George Wilson of the University of Kansas to evaluate the nanostructured membranes. The nanostructured membrane system can be used for a variety of implantable devices including biosensors, stents, hip and knee implants, and drug delivery systems. Anticipated socio-economic benefits of extending sensor lifetime include lower overall health costs to the nation, and improved quality of life.

IC Name
NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
  • Activity
    R43
  • Administering IC
    GM
  • Application Type
    5
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
    89245
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    821
  • Ed Inst. Type
  • Funding ICs
    NIGMS:89245\
  • Funding Mechanism
  • Study Section
    ZRG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    INFRAMAT CORPORATION
  • Organization Department
  • Organization DUNS
  • Organization City
    FARMINGTON
  • Organization State
    CT
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    060322597
  • Organization District
    UNITED STATES