Claims
- 1. A compound of formula I, ##STR9## in which Ra, Rb, Rc, Rd, Re, Rf and Rg, which may be the same or different, each represent hydrogen, amino, hydroxy, alkoxy, alkenyloxy, halogen, acyl, alkenyl, alkyl, or alkoxy substituted by phenyl,
- Rh is hydrogen, alkyl or --COOH,
- X is a hydrocarbon chain containing from 2 to 10 carbon atoms and optionally substituted by a hydroxy group,
- A has no significance or represents Y, OY, or SY and Y represents a C 1 to 4 hydrocarbon chain which is optionally substituted by alkyl C 1 to 4,
- E and G, which may be the same or different, each represent --O--, --S-- or --CH.sub.2 --, provided that at least one of E and G is --O-- or --S--,
- L, together with the carbon atoms to which it is attached, forms a benzene or pyran-2-one ring,
- Ra, Rb, Rc, Rd, Re, Rf, Rg and Rh, when they contain carbon, each containing less than 7 carbon atoms,
- and pharmaceutically acceptable salts, esters and amides thereof.
- 2. A compound according to claim 1, wherein Ra to Rg are selected from hydrogen, acetyl, formyl, hydroxy, methyl, propyl, allyl, allyloxy and chlorine.
- 3. A compound according to claim 1, wherein none, or only one, of Ra, Rb and Rc are other than hydrogen and two, three or four of Rd, Re, Rf and Rg are other than hydrogen.
- 4. A compound according to claim 3, wherein an adjacent three of Rd, Re, Rf and Rg are acetyl, hydroxy and propyl.
- 5. A compound according to claim 1, where A is not present or is Y or OY and Y is --CH.sub.2 -- or --CH(CH.sub.3)--.
- 6. A compound according to claim 1, wherein E and G are both oxygen or one is oxygen and the other is sulphur.
- 7. A compound according to claim 1, wherein E and G are both oxygen, Ra, Rb and Rc each represent hydrogen, alkyl or alkenyl, Rd, Re, Rf and Rg, each represent hydrogen, hydroxy, alkoxy, acyl, alkenyl, alkyl or alkoxy substituted by phenyl, Rh is hydrogen, A has no significance and L is a benzene ring.
- 8. A compound according to claim 1, wherein E and G are both oxygen, Rg, Ra and Rb are all hydrogen, Rc, Rd, Re and Rf are hydrogen, hydroxy, alkanoyl, alkenyl or alkyl and the ring L, together with the group --A--COOH is of formula, ##STR10## in which Rh is hydrogen or alkyl.
- 9. A compound according to claim 1 and selected from
- 7-(3-[4-Acetyl-3-hydroxy-2-propylphenoxy]-2-hydroxypropoxy)-8-propylnaphthalene-2-carboxylic acid,
- 7-(3-[4-Acetyl-3-hydroxy-2-propylphenoxy]-2-hydroxypropoxy)-4-methyl-2-oxo-2H-1-benzopyran-3-acetic acid,
- 6-[5-(2-Acetyl-3-hydroxyphenoxy)pentyloxy]naphthalene-2-carboxylic acid,
- 6-{5-[2-Acetyl-3-(prop-2-enyloxy)phenoxy]pentyloxy}naphthalene-2-carboxylic acid,
- 6-{5-[2-Acetyl-3-hydroxy-4-(prop-2-enyl)phenoxy]pentyloxy}naphthalene-2-carboxylic acid,
- [5-{5-(4-Methoxy-3-propylphenyl)pentyloxy)}-1-naphthalenyloxy]acetic acid,
- 7-(3-[4-Acetyl-3-hydroxy-2-propylphenoxy]-2-hydroxypropoxy)naphthalene-2-carboxylic acid,
- 6-(3-[4-Acetyl-3-hydroxy-2-propylphenoxy]propoxy)naphthalene-2-carboxylic acid,
- ({7-(3-[4-Acetyl-3-hydroxy-2-propylphenoxy]propoxy)-2-naphthalenyl}oxy)acetic acid,
- 7-(3-[4-Acetyl-3-hydroxy-2-propylphenylthio)propoxy]naphthalene-2-carboxylic acid,
- 7-(3-[4-Chloro-3-methylphenoxy)propoxy]naphthalene-2-carboxylic acid,
- 7-[2-(4-Acetyl-3-hydroxy-2-propylphenoxy)ethoxy]naphthalene-2-carboxylic acid,
- [{7-(3-[4-Acetyl-3-hydroxy-2,6-dipropylphenoxy]propoxy)-2-naphthalenyl}oxy]acetic acid,
- 6-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy]-.alpha.-methylnaphthalene-2-acetic acid,
- 6-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy]naphthalene-2-acetic acid,
- [{5-(3-[3-Formyl-2-(2-propenyl)phenoxy]propoxy)-1-naphthalenyl}oxy]acetic acid,
- [{5-(5-[4-Methoxy-3-propylphenyl]pentyloxy)-1-naphthalenyl}oxy]acetic acid,
- 7-{3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propyloxy)}-2-naphthalenepropanoic acid,
- and the sodium salts of any one thereof.
- 10. A pharmaceutical formulation comprising an effective anti SRS-A amount of a compound according to claim 1 in admixture with a pharmaceutically acceptable adjuvant, diluent or carrier.
- 11. A method of treatment of a disorder in which SRS-A is a factor, which comprises administration of an effective amount of a compound according to claim 1 to a patient suffering from such a condition.
Priority Claims (2)
Number |
Date |
Country |
Kind |
8109090 |
Mar 1981 |
GBX |
|
8120255 |
Jul 1981 |
GBX |
|
Parent Case Info
This is a division of application Ser. No. 359,817, filed Mar. 19, 1982, U.S. Pat. No. 4,424,231.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3882148 |
Augstein et al. |
May 1975 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
1144906 |
Mar 1969 |
GBX |
Divisions (1)
|
Number |
Date |
Country |
Parent |
359817 |
Mar 1982 |
|