Claims
- 1. A compound of the formula:
- 2. The compound according to claim 1, wherein R1 is naphthyl substituted by one to three C1-C5-alkoxy groups.
- 3. The compound according to claim 2, wherein R1 is naphthyl substituted by one C1-C3-alkoxy group.
- 4. The compound according to claim 3, wherein R1 is naphthyl substituted by methoxy.
- 5. The compound according to claim 4, wherein R1 is 4-methoxy-naphthalen-2yl.
- 6. The compound according to claim 5, wherein R2 is C1-C3-alkoxy benzyl.
- 7. The compound according to claim 6, wherein R2 is 2-methoxy benzyl.
- 8. The compound according to claim 7 which is (3S,4R,5R)-[4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-5-(4-methoxy-naphthalen-2-ylmethoxy)-piperidin-3-yl]-methanol.
- 9. A compound of the formula:
- 10. The compound according to claim 9, wherein R1 is naphthyl substituted by one to three C1-C5-alkoxy groups.
- 11. The compound according to claim 10, wherein R1 is naphthyl substituted by one C1-C3-alkoxy group.
- 12. The compound according to claim 11, wherein R1 is naphthyl substituted by methoxy.
- 13. The compound according to claim 12, wherein R1 is 4-methoxy-naphthalen-2yl.
- 14. The compound according to claim 13, wherein R2 is C1-C3-alkoxy benzyl.
- 15. The compound according to claim 14, wherein R2 is 2-methoxy benzyl.
- 16. The compound according to claim 15 which is (3S,4R,5R)-3-imidazol-1-ylmethyl-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-5-(4-methoxy-naphthalen-2-ylmethoxy)-piperidine dihydrochloride.
- 17. A compound of the formula:
- 18. The compound according to claim 17, wherein R1 is naphthyl substituted by one to three C1-C5-alkoxy groups.
- 19. The compound according to claim 18, wherein R1 is naphthyl substituted by one C1-C3-alkoxy group.
- 20. The compound according to claim 19, wherein R1 is naphthyl substituted by methoxy.
- 21. The compound according to claim 20, wherein R1 is 4-methoxy-naphthalen-2yl.
- 22. The compound according to claim 21, wherein R2 is phenyl substituted by one cyano group.
- 23. The compound according to claim 22, wherein R4 is hydrogen, l is 1, K is 1, and R3a is methoxy-ethoxy.
- 24. The compound according to claim 23 which is 2-[3-[4-[(3S,4R,5R)-3-[(2R)-2-hydroxy-3-(2-methoxy-ethoxy)-propoxy]-5-(4-methoxy-naphthalen-2-ylmethoxy)-piperidin-4-yl]-phenoxy]-propoxy]-benzonitrile.
- 25. The compound according to claim 21, wherein R2 is phenyl substituted by one nitro group.
- 26. The compound according to claim 25, wherein R4 is hydrogen, l is 2, K is 0, and R3a is hydrogen.
- 27. The compound according to claim 26 which is (R)-3-[(3S,4R,5R)-5-(4-methoxy-naphthalen-2-ylmethoxy)-4-[4-[3-(2-nitro-phenoxy)-propoxy]-phenyl]-piperidin-3-yloxy]-propane-1,2-diol.
- 28. The compound according to claim 25, wherein R4 is hydrogen, l is 1, K is 1, and R3a is triazolyl.
- 29. The compound according to claim 28 which is (R)-1-[(3S,4R,5R)-5-(4-methoxy-naphthalen-2-ylmethoxy)-4-[4-[3-(2-nitro-phenoxy)-propoxy]-phenyl]-piperidin-3-yloxy]-3-[1,2,4]triazol-1-yl-propan-2-ol.
- 30. The compound according to claim 25, wherein R4 is hydrogen, l is 1, K is 1, and R3a is imidazolyl.
- 31. The compound according to claim 30 which is (R)-1-imidazol-1-yl-3-[(3S,4R,5R)-5-(4-methoxy-naphthalen-2-ylmethoxy)-4-[4-[3-(2-nitro-phenoxy)-propoxy]-phenyl]piperidin-3-yloxy)-propan-2-ol.
Priority Claims (1)
Number |
Date |
Country |
Kind |
99108199.3 |
Apr 1999 |
EP |
|
CROSS REFERENCE TO RELATED APPLICATION
[0001] This is a divisional of copending application No. 09/542,303, filed Apr. 4, 2000.
Divisions (1)
|
Number |
Date |
Country |
Parent |
09542303 |
Apr 2000 |
US |
Child |
10023679 |
Dec 2001 |
US |