Claims
- 1. A compound of the formula ##STR12## wherein: A is --C.dbd. or --N.dbd.;
- B is --C.dbd.C--; --C.dbd.N-- or --N.dbd.C--;
- provided that A or B represents a nitrogen-containing group;
- X is --(CR.sub.4 R.sub.5).sub.a --(O).sub.b -13 (CR.sub.6 R.sub.7).sub.c --;
- a and c are 0, 1 or 2;
- b is 0 or 1;
- provided that a+b+c=1, 2 or 3;
- R is hydrogen, alkyl, alkoxyalkyl, hydroxyalkyl, nitro, halo, cyano, carbamoyl, alkyl carbamoyl, formyl aminoalkylene or amino;
- R.sub.1, R.sub.2, R.sub.3, R.sub.5, R.sub.6 and R.sub.7 are hydrogen, alkyl, or aralkyl;
- R.sub.4 is hydrogen, alkyl, aryl, or aralkyl;
- geminal R.sub.6 and R.sub.7 groups may together form a spiro substituent, --(CH.sub.2).sub.d --, where d is 2 to 5;
- or a pharmaceutically acceptable salt thereof.
- 2. A compound according to claim 1 where R is cyano, R.sub.2 is lower alkyl and R.sub.1, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are hydrogen or lower alkyl.
- 3. A compound according to claim 2 where
- R is cyano;
- R.sub.1 is hydrogen;
- R.sub.2 is methyl; and
- R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are hydrogen or methyl.
- 4. A compound according to claim 3 where
- A is --C.dbd.;
- B is --C.dbd.N--; and
- X is --O--CH.sub.2 --.
- 5. A compound according to claim 3 where
- A is --C.dbd.;
- B is --N.dbd.C--; and
- X is --O--CH.sub.2 --.
- 6. A compound according to claim 3 where
- A is --N.dbd.;
- B is --C.dbd.C--; and
- X is --O --CH.sub.2 --.
- 7. A compound according to claim 3 where
- A is --C.dbd.;
- B is --C.dbd.N--; and
- X is --CH.sub.2 --.
- 8. A compound according to claim 3 where
- A is --C.dbd.;
- B is --C.dbd.N--; and
- X is --O--.
- 9. A compound according to claim 3 where
- A is --C.dbd.;
- B is --C.dbd.N--; and
- X is --0--CH.sub.2 --CH.sub.2 --.
- 10. A compound according to claim 1 where b is 0.
- 11. A compound according to claim 10 where
- A is --C.dbd.; and
- B is --C.dbd.N--.
- 12. A compound according to claim 11 wherein a+c equals 1.
- 13. A compound according to claim 11 wherein a+c equals 2.
- 14. A compound according to claim 11 Wherein a+c equals 3.
- 15. A compound according to claim 12 wherein c is 1 and geminal R.sub.6 and R.sub.7 groups together form a spiro substituent.
- 16. A compound according to claim 11 wherein a=c=1 and geminal R.sub.6 and R.sub.7 groups together form a spiro substituent.
- 17. A compound according to claim 4 which is 7-[3,-cyano-6'-methyl-2'-oxo-(1)pyridin-5-yl]-4-ethyl-2H-pyrido[3,2-b]1,4-oxazin-3(4H)-one or a pharmaceutically acceptable salt thereof.
- 18. A compound according to claim 1 which is 7-[3,-cyano-6'-methyl-2'-oxo-(1H) pyridin-5,-yl]-2-phenyl-4-methyl-2H-pyrido[3,2-b ]-1,4-oxazin-3(4H)-one or a pharmaceutically acceptable salt thereof.
- 19. A compound according to claim 1 which is 8-[3'-cyano-6'-methyl-2'-oxo-(1H) pyridin-5,-yl]-5-methyl-2,3-dihydropyrido[4,3-b][1,4]oxazepin-4(5H)-one or a pharmaceutically acceptable salt thereof.
- 20. A compound according to claim 13 where R is cyano, R.sub.2 is lower alkyl and R.sub.1, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are hydrogen or lower alkyl.
- 21. A compound according to claim 11 which is 6-[3,-cyano-6'-methyl-2'-oxo-(1H) pyridin-5,-yl]-3,4-dihydro-1-methyl-1,8-naphtheridin-2(1H)-one or a pharmaceutically acceptable salt thereof.
- 22. A method for increasing cardiotonic contractility in a patient requiring such treatment which comprises administering to such patient an effective amount of a compound according to claim 1.
- 23. A pharmaceutical composition wherein the active ingredient is a compound according to claim 1 in admixture with a pharmaceutical carrier.
Parent Case Info
a continuation-in-part of U.S. Ser. No. 47,394, filed May 8, 1987,and PCT/US88/01504 filed May 4, 1988.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3984405 |
Krapcho |
Oct 1976 |
|
4822794 |
Spada et al. |
Apr 1989 |
|
4866074 |
Spada et al. |
Sep 1989 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
47394 |
May 1987 |
|