Claims
- 1. A heterocyclic compound of the formula: ##STR10## wherein the pyrroline ring and the symbols X.sub.1 and X.sub.2 together form an isoindoline nucleus or an isoindoline nucleus substituted by one or two atoms or radicals selected from halogen, alkyl of 1 through 4 carbon atoms, alkoxy of 1 through 4 carbon atoms, nitro and trifluoromethyl, the symbols Y.sub.1 and Y.sub.2 each represent hydrogen, halogen, alkyl of 1 through 4 carbon atoms, alkoxy of 1 through 4 carbon atoms, or cyano, and the symbols R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a morpholino ring, and when appropriate non-toxic pharmaceutically acceptable acid addition salts thereof.
- 2. A heterocyclic compound according to claim 1 wherein the pyrroline ring and the symbols X.sub.1 and X.sub.2 together form an isoindoline nucleus or an isoindoline nucleus substituted by halogen or trifluoromethyl, Y.sub.1 represents halogen in the 7-position of the 1,8-naphthyridin-2-yl nucleus, Y.sub.2 represents hydrogen, and R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a morpholino ring.
- 3. A heterocyclic compound according to claim 1 wherein the pyrroline ring and the symbols X.sub.1 and X.sub.2 form an isoindoline nucleus, Y.sub.1 represents chlorine in the 7-position of the 1,8-naphthyridin-2-yl nucleus, Y.sub.2 represents hydrogen atom, and R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a morpholino ring.
- 4. A heterocyclic compound according to claim 1 wherein halogen is chlorine.
- 5. A heterocyclic compound according to claim 1 which is 2-(7-chloro-1,8-naphthyridin-2-yl)-3-[(4-morpholino)carbonyloxy]-isoindolin-1-one.
- 6. Tranquilliser, hypnotic, anti-convulsant and anti-spasmodic pharmaceutical compositions which comprise, as an active ingredient, an effective amount of a heterocyclic compound as claimed in claim 1, or -- when appropriate -- a non-toxic pharmaceutically acceptable acid addition salt thereof, in association with a significant amount of a pharmaceutical carrier.
Priority Claims (3)
Number |
Date |
Country |
Kind |
75 10756 |
Apr 1975 |
FR |
|
76 03773 |
Feb 1976 |
FR |
|
76 03774 |
Feb 1976 |
FR |
|
Parent Case Info
This is a division of application Ser. No. 673,868 filed April 5, 1976.
Non-Patent Literature Citations (1)
Entry |
cotrel et al., "Chem. Abstracts," vol. 85, (1976), No. 46758m. |
Divisions (1)
|
Number |
Date |
Country |
Parent |
673868 |
Apr 1976 |
|