Claims
- 1. (S)-(−)-7-(5-Fluoro-2-methylphenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline or a prodrug or a salt thereof.
- 2. (S)-(−)-7-(2-Chloro-5-fluorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline or a prodrug or a salt thereof.
- 3. A composition comprising (S)-(−)-7-(5-fluoro-2-methylphenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline or a prodrug or a salt thereof; or (S)-(−)-7-(2-chloro-5-fluorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline or a prodrug or a salt thereof and a pharmaceutically acceptable carrier.
- 4. A method for inhibiting Na—H exchange in mammals comprising administering an effective amount of (S)-(−)-7-(5-fluoro-2-methylphenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline or a prodrug or a salt thereof; or (S)-(−)-7-(2-chloro-5-fluorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline or a prodrug or a salt thereof to said mammals.
Priority Claims (1)
Number |
Date |
Country |
Kind |
11-156773 |
Jun 1999 |
JP |
|
Parent Case Info
This application is the National Stage of International Application No. PCT/JP00/03559, filed on Jun. 1, 2000.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
PCT/JP00/03559 |
|
WO |
00 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO00/75115 |
12/14/2000 |
WO |
A |
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