Nebulizer with flow-based fluidic control and related methods

Abstract

Various embodiments of a breath-activated nebulizer with flow-based fluidic control and related methods of using such a nebulizer are disclosed. The nebulizer may include a body comprising a reservoir for holding medication, a nozzle for emitting a jet of pressurized gas, and a fluid conduit in communication with the reservoir for delivery of the medication proximate the jet to produce an aerosol of medication. The nebulizer may also include a nebulizer outlet in communication with the body for delivery of the aerosol to a patient, an entrainment passage for providing entrainment flow from atmosphere during inhalation by the patient, and a control conduit in fluid communication with the fluid conduit for delivery of a control gas to the fluid conduit to prevent the delivery of the medication proximate the jet. In some exemplary embodiments, the control conduit may comprise a gas passage proximate the entrainment passage to allow the control gas to flow across the entrainment passage. During the inhalation by the patient, the entrainment flow through the entrainment passage may substantially prevent the control gas from flowing across the entrainment passage so as to interrupt the delivery of the control gas to the fluid conduit.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate various embodiments consistent with the invention, and, together with the description, serve to explain the principles of the invention.

FIG. 1 is a schematic view of a nebulizer, according to an exemplary embodiment of the invention, illustrating a non-nebulizing mode.

FIG. 2 is a schematic view of the nebulizer of FIG. 1, illustrating a nebulizing mode.

FIG. 2A is a schematic view of a venturi, according to an exemplary embodiment of the invention.

FIG. 2B is a schematic view of a venturi, according to another exemplary embodiment of the invention.

FIG. 2C is a schematic view of a venturi, according to still another exemplary embodiment of the invention.

FIG. 3 is a partial schematic view of a nebulizer system, according to still another exemplary embodiment of the invention, illustrating an alternative or additional control flow regulator.

FIGS. 4A and 4B are schematic views of a control flow stopper in a non-nebulizing mode and a nebulizing mode, respectively, according to an exemplary embodiment of the invention.

FIG. 5 is a schematic view of a flapper valve used in a control flow stopper, according to another exemplary embodiment of the invention.

FIGS. 5A and 5B are schematic views of a control flow stopper utilizing the flapper valve of FIG. 5 to switch between a non-nebulizing mode and a nebulizing mode.

FIGS. 5C and 5D are schematic views of another control flow stopper utilizing the flapper valve of FIG. 5 to switch between a non-nebulizing mode and a nebulizing mode

FIG. 6A is a perspective view of a nebulizer, according to another exemplary embodiment of the invention.

FIG. 6B is a perspective view of the nebulizer of FIG. 6A, illustrating various parts of the nebulizer.

FIG. 7 is a cross-sectional, perspective view of the nebulizer of FIG. 6A.

FIGS. 8 and 9 are cross-sectional views of the nebulizer of FIG. 6A, illustrating control flow directions during a non-nebulizing mode and a nebulizing mode, respectively.

FIG. 10 is a partial cross-sectional, perspective view of the nebulizer of FIG. 6A, illustrating an exemplary control flow regulator.

FIG. 11 is a perspective view of a nebulizer, according to another exemplary embodiment of the invention.

FIG. 12 is a perspective view of the nebulizer of FIG. 11, illustrating various parts of the nebulizer.

FIGS. 13 and 14 are cross-sectional, perspective views of the nebulizer of FIG. 11, illustrating flow directions within the nebulizer during patient inhalation and exhalation, respectively.

FIGS. 15-17 are cross-sectional, perspective views of the nebulizer of FIG. 11, illustrating control flow directions during a non-nebulizing mode.

FIG. 18 is a cross-sectional, perspective view of the nebulizer of FIG. 11, illustrating control flow directions during a nebulizing mode.

FIGS. 19 and 20 are partial cross-sectional, schematic views of the nebulizer of FIG. 11, illustrating a manual override mechanism in an unactivated state and an activated state, respectively, according to an exemplary embodiment of the invention.

Claims

1. A nebulizer comprising: a body comprising a reservoir for holding medication;a nozzle for emitting a jet of pressurized gas;a fluid conduit in communication with the reservoir for delivery of the medication proximate the jet to produce an aerosol of medication;a nebulizer outlet in communication with the body for delivery of the aerosol to a patient;an entrainment passage for providing entrainment flow from atmosphere during inhalation by the patient; anda control conduit in fluid communication with the fluid conduit for delivery of a control gas to the fluid conduit to prevent the delivery of the medication proximate the jet, the control conduit comprising a gas passage proximate the entrainment passage to allow the control gas to flow across the entrainment passage,wherein, during the inhalation by the patient, the entrainment flow through the entrainment passage substantially prevents the control gas from flowing across the entrainment passage so as to interrupt the delivery of the control gas to the fluid conduit.

2. The nebulizer of claim 1, wherein the entrainment passage comprises a venturi.

3. The nebulizer of claim 2, wherein the venturi comprises an inlet in fluid communication with atmosphere and an outlet in fluid communication with an interior of the body.

4. The nebulizer of claim 2, wherein the gas passage is disposed proximate a throat of the venturi.

5. The nebulizer of claim 4, wherein the venturi comprises a recessed portion adjacent the throat to facilitate the interruption of the control gas across the entrainment passage.

6. The nebulizer of claim 2, wherein the venturi is disposed inside the body.

7. The nebulizer of claim 1, further comprising a flow guide positioned adjacent the gas passage and configured to prevent the control gas from flowing across the entrainment passage during the inhalation by the patient.

8. The nebulizer of claim 1, wherein the gas passage comprises: an inlet port in fluid communication with the entrainment passage; andan outlet port in fluid communication with the entrainment passage;wherein the gas passage is configured to transport the control gas from the inlet port to the outlet port across the entrainment passage.

9. The nebulizer of claim 8, wherein the inlet port and the outlet port are aligned in a direction substantially perpendicular to a longitudinal axis of the entrainment passage.

10. The nebulizer of claim 1, wherein the pressurized gas and the control gas are delivered from a same source of gas, the control gas being drawn from a main gas line that supplies the pressurized gas to the nozzle.

11. The nebulizer of claim 10, further comprising a control flow manifold configured to direct the control gas drawn from the main gas line to the control conduit.

12. The nebulizer of claim 11, wherein the control flow manifold comprises an opening in the main gas line.

13. The nebulizer of claim 1, further comprising a flow regulator for controlling a flow of the control gas.

14. The nebulizer of claim 13, whether the flow regulator comprises a through-hole in a sleeve that at least partially defines the fluid conduit.

15. The nebulizer of claim 13, wherein the flow regulator comprises a valve disposed over an orifice in fluid communication with the control conduit, the valve being configured to open the orifice to vent excess control flow when the control gas flowing through the control conduit exceeds a threshold value.

16. The nebulizer of claim 1, wherein the gas passage comprises: an inlet port; andan outlet port facing the inlet port;wherein the gas passage is configured to transport the control gas from the inlet port to the outlet port across the entrainment passage,wherein the nebulizer further comprises a flow stopper movable between a first position, in which the stopper permits the flow of the control gas between the inlet and outlet ports, and a second position, in which the stopper substantially prevents the flow of the control gas across the entrainment passage, andwherein the inhalation by the patient causes the stopper to move from the first position to the second position.

17. The nebulizer of claim 16, wherein the movement of the flow stopper is controlled by a valve that moves in response to a patient's breath.

18. The nebulizer of claim 1, further comprising a stationary diverter to which the jet of pressurized gas is directed.

19. The nebulizer of claim 1, further comprising an override mechanism configured to override breath actuation of the nebulizer.

20. The nebulizer of claim 19, wherein the nebulizer is configured to continuously generate the aerosol when the override mechanism is actuated.

21. The nebulizer of claim 19, wherein the override mechanism comprises: a bypass conduit connecting between the control conduit and atmosphere; anda valve disposed in the bypass conduit to open and close the bypass conduit,wherein, upon actuation of the override mechanism, the valve opens the bypass conduit to vent the control gas from the control conduit to atmosphere, so as to prevent the delivery of the control gas to the fluid conduit.

22. A nebulizer comprising: a body comprising a reservoir for holding medication;a nozzle for emitting a jet of pressurized gas;a fluid conduit in communication with the reservoir for delivery of the medication proximate the jet to produce an aerosol of medication;a nebulizer outlet in communication with an interior of the body for delivery of the aerosol to a patient;a control conduit in fluid communication with the fluid conduit for delivery of a control gas to the fluid conduit to prevent the delivery of the medication proximate the jet, a portion of the control conduit permitting a flow of the control gas across a gap; anda flow stopper movable between a first position, in which the stopper is disposed out of the gap to permit the flow of the control gas across the gap, and a second position, in which the stopper is disposed in the gap to substantially prevent the flow of the control gas across the gap;wherein the inhalation by the patient causes the stopper to move from the first position to the second position.

23. The nebulizer of claim 22, wherein the movement of the flow stopper is controlled by a variable area orifice valve that actuates in response to the patient's inhalation.

24. The nebulizer of claim 22, wherein the flow stopper comprises a plate member movably disposed in and out of the gap.

25. The nebulizer of claim 22, wherein the portion of the control conduit is disposed in an entrainment passage that provides entrainment flow from atmosphere during the inhalation by the patient.

26. The nebulizer of claim 22, wherein the portion of the control conduit comprises an inlet port and an outlet port facing the inlet port, so as to transport the control gas from the inlet port to the outlet port, wherein a space between the inlet and outlet ports defines the gap.

27. The nebulizer of claim 22, wherein the pressurized gas and the control gas are delivered from a same source of gas, the control gas being drawn from a main gas line that supplies the pressurized gas to the nozzle.

28. The nebulizer of claim 27, further comprising a control flow manifold configured to direct the control gas drawn from the main gas line to the control conduit.

29. The nebulizer of claim 22, further comprising a flow regulator for controlling a flow of the control gas.

30. The nebulizer of claim 29, whether the flow regulator comprises a through-hole in a sleeve that at least partially defines the fluid conduit.

31. The nebulizer of claim 22, further comprising a stationary diverter to which the jet of pressurized gas is directed.

32. The nebulizer of claim 22, further comprising an override mechanism configured to override breath actuation of the nebulizer.

33. The nebulizer of claim 32, wherein the override mechanism comprises: a bypass conduit connecting between the control conduit and atmosphere; anda valve disposed in the bypass conduit to open and close the bypass conduit,wherein, upon actuation of the override mechanism, the valve opens the bypass conduit to vent the control gas from the control conduit to atmosphere, so as to prevent the delivery of the control gas to the fluid conduit.

34. A method of controlling a nebulization process, comprising: providing medication in a reservoir within a body, the body comprising an outlet for delivery of medication to a patient and an entrainment passage for providing entrainment flow from atmosphere during inhalation by the patient;emitting a jet of pressurized gas into the body;providing a fluid conduit in communication with the reservoir for delivery of the medication proximate the jet;preventing delivery of the medication proximate the jet by delivering a control gas to the fluid conduit via a control conduit, the control conduit comprising a gas passage proximate the entrainment passage to allow the control gas to flow across the entrainment passage; andinterrupting the flow of the control gas across the entrainment passage to prevent the delivery of the control gas to the control conduit, the interruption permitting delivery of the medication proximate the jet to produce an aerosol of medication.

35. The method of claim 34, wherein, during the inhalation by the patient, the entrainment flow through the entrainment passage substantially interrupts the flow of the control gas across the entrainment passage.

36. The method of claim 34, wherein the entrainment passage comprises a venturi.

37. The method of claim 36, wherein the gas passage is disposed proximate a throat of the venturi.

38. The nebulizer of claim 34, further comprising providing a flow guide adjacent the gas passage proximate the entrainment passage to prevent the control gas from flowing across the entrainment passage during the inhalation by the patient.

39. The method of claim 34, wherein the gas passage comprises: an inlet port in fluid communication with the entrainment passage; andan outlet port in fluid communication with the entrainment passage;wherein the gas passage is configured to transport the control gas from the inlet port to the outlet port across the entrainment passage.

40. The method of claim 39, further comprising providing a flow stopper movable between a first position, in which the stopper permits the flow of the control gas between the inlet and outlet ports, and a second position, in which the stopper substantially prevents the flow of the control gas across the entrainment passage, wherein the inhalation by the patient causes the stopper to move from the first position to the second position.

41. The method of claim 34, wherein the pressurized gas and the control gas are delivered from a same source of gas, the control gas being drawn from a main gas line that supplies the pressurized gas.

42. The method of claim 34, further comprising regulating a flow of the control gas to the control conduit via a flow regulator.

43. The method of claim 42, wherein the flow regulator comprises a valve disposed over an orifice in fluid communication with the control conduit, the valve being configured to open the orifice to vent excess control flow when the control gas flowing through the control conduit exceeds a threshold value.

44. The method of claim 34, further comprising regulating a flow of the control gas via a through-hole in a sleeve that at least partially defines the fluid conduit.

45. The method of claim 34, further comprising directing the jet of pressurized gas towards a stationary diverter.

46. The method of claim 34, further comprising overriding the control of the nebulization process to continuously generate the aerosol of medication.

47. The method of claim 46, wherein the overriding comprises: providing a bypass conduit connecting between the control conduit and atmosphere;disposing a valve in the bypass conduit; andopening the valve to open the bypass conduit so as to vent the control gas from the control conduit to atmosphere.

48. A method of controlling a nebulization process, comprising: providing medication in a reservoir within a body, the body comprising an outlet for delivering medication to a patient;emitting a jet of pressurized gas into the body;providing a fluid conduit in communication with the reservoir for delivery of the medication proximate the jet;preventing delivery of the medication proximate the jet by delivering a control gas to the fluid conduit via a control conduit, a portion of the control conduit permitting a flow of the control gas across a gap;providing a flow stopper movable between a first position, in which the stopper is disposed out of the gap to permit the flow of the control gas across the gap, and a second position, in which the stopper is disposed in the gap to substantially prevent the flow of the control gas across the gap; andinterrupting the flow of the control gas across the gap by the flow stopper to prevent the delivery of the control gas to the control conduit, the interruption permitting delivery of the medication proximate the jet to produce an aerosol of medication.

49. The method of claim 48, wherein the flow stopper is movable from the first position to the second position in response to inhalation by the patient.

50. The method of claim 49, wherein the movement of the flow stopper is controlled by a valve that actuates in response to the patient's inhalation.

51. The method of claim 49, wherein the portion of the control conduit is disposed in an entrainment passage that provides entrainment flow from atmosphere during the inhalation by the patient.

52. The method of claim 48, wherein the flow stopper comprises a plate member movably disposed in and out of the gap.

53. The method of claim 48, wherein the portion of the control conduit comprises an inlet port and an outlet port facing the inlet port, so as to transport the control gas from the inlet port to the outlet port, wherein a space between the inlet and outlet ports defines the gap.

54. The method of claim 48, wherein the pressurized gas and the control gas are delivered from a same source of gas, the control gas being drawn from a main gas line that supplies the pressurized gas.

55. The method of claim 48, further comprising regulating a flow of the control gas to the control conduit via a flow regulator.

56. The method of claim 55, wherein the flow regulator comprises a valve disposed over an orifice in fluid communication with the control conduit, the valve being configured to open the orifice to vent excess control flow when the control gas flowing through the control conduit exceeds a threshold value.

57. The method of claim 48, further comprising regulating a flow of the control gas via a through-hole in a sleeve that at least partially defines the fluid conduit.

58. The method of claim 48, further comprising directing the jet of pressurized gas towards a stationary diverter.

59. The method of claim 48, further comprising overriding the control of the nebulization process to continuously generate the aerosol of medication.

60. The method of claim 59, wherein the overriding comprises: providing a bypass conduit connecting between the control conduit and atmosphere;disposing a valve in the bypass conduit; andopening the valve to open the bypass conduit so as to vent the control gas from the control conduit to atmosphere.