Claims
- 1. An electrode apparatus for the application of electric fields to a selected tissue of a living body, comprising(a) a pair of needles, wherein each needle in the pair has a lumen through which an electrode can enter the proximal end and exit through the distal end and can penetrate tissue for in vivo electroporation of cells of the tissue, (b) a pair of electrodes, wherein each electrode is fed through the lumen of the respective needle and thereby into the tissue, and (c) a power generator to apply an electric potential of sufficient strength across the electrodes to generate an electric field in the tissue for electroporation of cells of the tissue.
- 2. An apparatus according to claim 1, wherein said pair of needles comprises tubular needles for inserting into selected tissue.
- 3. An apparatus according to claim 1, wherein said needles in the pair are removable over said electrodes.
- 4. An apparatus according to claim 1, wherein said needles in the pair are nonconductive.
- 5. An apparatus according to claim 1, wherein the electrodes comprise an elongated insulated conductor with conductive tips.
- 6. An apparatus according to claim 1, wherein the needles are connected to a source of molecules and used to inject a selected molecular solution into the tissue area.
REFERENCE TO RELATED APPLICATIONS
The present application is a Continuation of co-pending U.S. application Ser. No. 09/551,327, filed on Apr. 18, 2000 now U.S. Pat. No. 6,418,341, which is a Divisional of U.S. application Ser. No. 09/427,151, filed on Oct. 25, 1999 now U.S. Pat. No. 6,451,002, which is a Continuation of U.S. application Ser. No. 08/537,265 filed on Sep. 29, 1995 now U.S. Pat. No. 5,993,434, which is a continuation-in-part of U.S. application Ser. No 08/467,566 filed Jun. 6, 1995 now U.S. Pat. No. 5,702,359 which is a Continuation-in-Part of U.S. application Ser. No. 08/042,039 filed on Apr. 1, 1993, now issued U.S. Pat. No. 5,439,440, the contents of which are hereby incorporated by reference in their entirety.
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Continuations (2)
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Number |
Date |
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Parent |
09/551327 |
Apr 2000 |
US |
Child |
10/053861 |
|
US |
Parent |
08/537265 |
Sep 1995 |
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Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
08/467566 |
Jun 1995 |
US |
Child |
08/537265 |
|
US |
Parent |
08/042039 |
Apr 1993 |
US |
Child |
08/467566 |
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US |