Aoki, Y., et al., "Effects of Recombinant Human Soluble Thrombomodulin (rhs-TM) on a Rat Model of Disseminated Intravascular Coagulation with Decreased Levels of Plasma Antithrombin" Thrombosis and Hemostasis 71(4):452-455 (1994). |
Babin et al., "The Isoinhibitors of Chymotrypsin/Elastase from Ascaris lumbricoides: The Primary Structure" Arch. of Biochem. and Biophy. 232(1):143-161 (1984). |
Beaucage et al., "Deoxynucleoside Phosphoramidites--A New Class of Key Intermediates for Deoxypolynucleotide Synthesis" Tetrahedron Letters, 22(20):1859-1862 (1981). |
Bernard, et al., "The Serine Protease Inhibitor Family from Ascaris Suum: Chemical Determination of the Five Disulfide Bridges" Arch. Biochem. Biophys., 303(2):367-376 (1993). |
Bock, P.E. et al. "Isolation of Human Coagulation a-Factor X.sub.a by Soybean Trypsin Inhibitor-Sepharose Chromatography and Its Active-Site Titration with Fluorescein Mono-p-guanidinobenzoate" Archives of Biochem. Biophys. 273(2):375-388 (1989). |
Bolivar et al., "Construction and Characterization of New Cloning Vehicles" Gene, 2:95-113 (1977). |
Broach, J. et al., "Transformation in Yeast: Development of a Hybrid Cloning Vector and Isolation of the CAN1 Gene" Gene, 8:121-133 (1978). |
Brown, E. et al., "Chemical Synthesis and Cloning of a Tyrosine tRNA Gene" Methods in Enzymology, 68, 109-151 (1979). |
Bullock et al., "XL1-Blue: A High Efficiency Plasmid Transforming recA Escherichia coli Strain with Beta-Galactosidase Selection" Biotechniques 5(4):376-379 (1987). |
Cairns et al., "Antithrombotic Agents in Coronary Artery Disease" Chest 102:456S-481S (1992). |
Crameri et al., "Display of Biologically Active Proteins on the Surface of Filamentous Phages: a cDNA Cloning System for Selection of Functional Gene Products Linked to the Genetic Information Responsible for their Production" Gene, 137:69-75 (1993). |
Cappello et al., "Ancylostoma Factor Xa Inhibitor: Partial Purification and Its Identification as a Major Hookworm-Derived Anticoagulant in Vitro" J. Infect. Diseases, 167:1474-1477 (1993). |
Cappello et al., "Ancylostoma caninum anticoagulant peptide: A hookworm-derived Inhibitor of Human Coagulation Factor Xa," Proc. Natl. Acad Sci. U.S.A. 92:6152-6156 (1995). |
Carroll et al., "The Anticoagulant Effects of the Hookworm, Ancyclostoma Ceylanicum: Observations on Human and Dog Blood In Vitro and Infected Dogs in Vivo" Thromb. Haemostas. (Stuttgart), 51(2):222-227 (1984). |
Carson, "Computerized Analysis of Enzyme Cascade Reactions Using Continuous Rate Data Obtained with an ELISA Reader" Comput. Prog. Biomed 19:151-157 (1985). |
Clements et al., "Secretion of Human Epidermal Growth Factor from Saccharomyces Cerevisiae Using Synthetic Leader Sequences" Gene 106:267-272 (1991). |
Cohen, Nonchromosomal Antibiotic Resistance in Bacteria: Genetic Transformation of Escherichia coli by R-Factor DNA Proc. Natl. Acad. Sci. USA, 69(8):2110-2114 (1972). |
Crawford, et al., "Inhibition of Human Blood Clotting By Extracts of Ascaris Suum" J. Parasitol., 68(6):1044-1047 (1982). |
Curtis, Biology Fourth ed. N.Y. Worth Publishers, Inc. pp. 500-501 (1983). |
Depicker et al., "Nopaline Synthase: Transcript Mapping and DNA Sequence" J. Mol. Appl. Gen., 1(6):561-573 (1978). |
Despreaux et al., "The dac A Gene of Bacillus Stearothermophilus Coding for D-Alanine Carboxypeptidase: Cloning, Structure and Expression in Escherichia Coli and Pichia Pastoris" Gene 131:35-41 (1993). |
Fiers, et al., "Complete Nucleotide Sequence of SV40 DNA" Nature, 273:113-120 (1978). |
Fuster, V. The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes New Eng. J. Med. 326(5):310-318 (1992). |
Glaser-Wuttke, G., "Pore-Forming Properties of the Adsorption protein of Filamentous Phage fd" Biochem. Biophys. Acta, 985:239-247 (1989). |
Glover, "Gene Cloning: The Mechanics of DNA Manipulation" 1-20 (1984). |
Goeddel et al., "Synthesis of Human Fibroblast Interferon by E. Coli" Nucleic Acids Res., 8(18):4057-4074 (1980). |
Gold et al., "Evidence for a Rebound Coagulation Phenomenon After Cessation of a 4-hour Infusion of a Specific Thrombin Inhibitor in Patients with Unstable Angina Pectoris" JACC 21(5):1039-1047 (1993). |
Grasberger et al., "High-Resolution Structure of Ascaris Trypsin Inhibitor in Solution: Direct Evidence for a pH-induced Conformational Transition in the Reactive Site" Structure, 2:669-678 (1994). |
Hemker et al., "Feedback Mechanisms in Coagulation" Hemostasis 21:189-196 (1991). |
Hirsh, J., "Heparin" N. Engl. J.Med 324(22):1565-1574 (1992). |
Hitzeman et al., "Isolation and Characterization of the Yeast 3-Phosphoglycerokinase Gene (PGK) by an Immunological Screening Technique" J. Biol. Chem., 255(24):12073-12080 (1980). |
Holland et al., "The Primary Structures of Two Yeast Enolase Genes" J. Biol. Chem., 256(3):1385-1395 (1981). |
Houghten, "General Method for the Rapid Solid-Phase Synthesis of Large Numbers of Peptides: Specificity of Antigen-Antibody Interaction at the level of Individual Amino Acids" Proc. Natl. Acad. Sci., 82:5131-5135 (1985). |
Hsiao, C.L. et al., "High-Frequency Transformation of Yeast by Plasmids Containing the Cloned Yeast ARG4 Gene" Proc.Natl. Acad. Sci. USA 76(8):3829-3833 (1979). |
Huang et al., "The Molecular Structure of the Complex of the Complex of Ascaris Chymotrypsin/Elastase Inhibitor with Porcine Elastase" Structure 2:679-689 (1994). |
Itakura et al., "Expression in Escherichia Coli of a Chmically Synthesized Gene for the Hormone Somatostatin" Science 198:1056-1063 (1977). |
Kasten, B.L., "Specimen Collection", Laboratory Test Handbook, 2nd Edition, Lexi-Comp Inc., Cleveland pp. 16-17 (Edits. Jacobs, D.S. et al. 1990). |
Kessler, C. "The Pharmacology of Aspirin, Heparin, Coumarin and Thrombolytic Agents" Chest 99:97S-112S (1991). |
Kurz, K.D., et al., "Rat Model of Arterial Thrombosis Induced by Ferric Chloride" Thromb. Res. 60:269-280 (1990). |
Lawson et al., "A Model for the Tissue Factor Pathway to Thrombin" J. Biol. Chem. 269(37):23357-23366 (1994). |
Levine et al., "Hemmorrhagic Complications of Anticoagulant Treatment" Chest 102:352S-363S (1992). |
Lidon et al., "Initial Experience with Direct Antithrombin Hirulog, in Unstable Angina" Circulation 88(4):1495-1501 (1993). |
Loeb et al., "The Presence of a Substance Inhibiting the Coagulation of the Blood in Ancyclostoma" Proc. Pathol. Soc.of Philadelphia, 7(6):173-178 (1904). |
Lucchesi et al., "Prevention of Thrombosis and Rethrombosis and Enhancement of the Thrombolytic Actions of Recombinant Tissue-Type Plasminogen Activator in the Canine Heart by DMP728, A Glycoprotein lib/IIIa Antagonist" Brit. J. Pharmacol. 113:1333-1343 (1994). |
Maniatis et al., "Molecular Cloning: A Laboratory Manual" Cold Spring Harbor Press p. 254-255 (1982). |
Mann et al., "Surface-Dependent Hemostasis" Sem. Hematology 29(3):213-226 (1992). |
Mann et al., "Blood" Journal of The American Society of Hematology 76(1):1-16 (1990). |
Merrifield, "Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide" J. Amer. Chem. Soc. 85:2149-2154 (1963). |
Messing et al., "A System for Shotgun DNA Sequencing" Nucleic Acids Res. 9(2): 309-321 (1981). |
Methods of Enzymology, 65:499-560 (1980). |
Mizushima et al., "pEF-BOS, A Powerful Mammalian Expression Vector" Nucl. Acids Res., 18(17):5322 (1990). |
Morrison et al., "The Behavior and Significance of Slow-Binding Enzyme Inhibitors" C. T. Adv. Enzymol. 61:201-301 (1988). |
Maruyama et al., "Lambda foo: a phage vector for the expression of foreign proteins" Proc. Nat'l Acad. Sci., USA 91:8273-8277 (1994). |
Narang et al., "Improved Phosphotriester Method for the Synthesis of Gene Fragments" Methods in Enzymol 68:90-109 (1979). |
Nawa et al., "The Glycosaminoglycan of Recombinant Human Soluble Thrombomodulin Affects Antithrombotic Activity in a Rat Model of Tissue Factor-Induced Disseminated Intravascular Coagulation" Thrombosis and Hemostasis 67(3):366-370 (1992). |
Nutt et al., "The Amino Acid Sequence of Antistasin" J. Biol. Chem, 263(21):10162-10167 (1988). |
Oklahoma Medical Research Foundation, "Thrombin-binding polypeptides as antithrombotic agent for artificial organs or other surfaces" Chemical Abstracts 113:18 abstract No. 158738 (1990). |
"Principles and Applications for DNA Amplification" PCR Technology (1989) (complete volume). |
Pritchard D., "The Anti-haemostatic Strategies of the Human Hookworm Necator Americanus" Thromb. Haemost. 73(3):546 (1995). |
"The Source for Discovery" Protocols and Applications Guide 3rd ed. Promega Corp. USA (1996) (complete volume). |
Rappaport, S., "Initiation and Regulation of Tissue Factor-Dependent Blood Coagulation" Arteriosclerosis and Thrombosis 12(10):1111-1121 (1992). |
Roberts et al., "Directed Evolution of a Potent Neutrophil Elastase Inhibitors Displayed on M13 Fusion Phage" Proc. Nat'l Acad. Sci., USA 89:2429-2433 (1992). |
Ruf et al., "Mutational Analysis of Receptor and Cofactor Function of Tissue Factor" Methods in Enzymol. 222, 209-224 (1993). |
Salvenson et al., "Proteinase Inhibitors: a-Macroglobulins, Serpins and Kunins", Hemostasis and Thrombosis Third ed. 251-253 (1994) J.B. Lippincott Comp. |
Sambrook et al., "Molecular Cloning, A Laboratory Manual", Second Edition, vols. 1 to 3, Cold Spring Harbor Laboratory Press (1989). |
Sanger et al., "DNA Sequencing with Chain-Terminating Inhibitors" Proc. Natl. Acad. Sci. USA, 74(12):5463-5467 (1977). |
Sharma et al., "Usefulness and Tolerability of Hirulog, A Direct Thrombin-Inhibitor, in Unstable Angina Pectoris" Am. J.of Cardiol. 72:1357-1360 (1993). |
Shaw et al., "A General Method for the Transfer of Cloned Genes to Plant Cells" Gene, 23:15-330 (1983). |
Shimatake et al., "Purified Regulatory Protein cII Positively Activates Promoters for Lysogenic Development" Nature, 292:128-132 (1981). |
Shulman et al., "Platelet Dynamics" Hemostasis and Thrombosis: Basic Principles and Clinical Practice 251-253 (1982) J.B. Lippincott Comp. |
Sikela et al., "Screening an Expression Library with a Ligand Probe: Isolation and Sequence of a cDNA Corresponding to a Brain Calmodulin-Binding Protein" Proc. Nat'l. Acad. Sci., USA, 84:3038-3042 (1987). |
Smith et al., "Libraries of Peptides and Proteins Displayed on Filamentous Phage" Methods of Enzomol. 217, 228-257 (1993). |
Soumillion et al., "Selection of lactamase on Filamentous Bacteriophage by Catalytic Activity" J. Mol. Biol. 237:415-422 (1994). |
Spellman et al., "Anticoagulant Activity of Dog Hookworm" Am. J. Physiol. 220(4):922-927 (1971). |
Stanssens et al., "Anticoagulant Repertoire of the Hookworm Ancylostoma Caninum" Proc. Natl. Acad. Sci. U.S.A. 93:2149-2154 (1996). |
Taylor, "Identification of Protein Sequence Homology by Consensus Template Alignment" J. Mol. Biol. 188:233-258 (1986). |
Tuszynski et al., "Isolation and Characterization of Antistatin" J. Biol. Chem. 262(20):9718-9723 (1987). |
Van Solingen et al., "Fusion of Yeast Spheroplasts" J. Bacter. 130:946-947 (1977). |
Van Lenten et al., "Studies on the Chemical and Enzymatic Modification of Glycoproteins" J. of Biol. Chem. 246(6):1889-1894 (1971). |
Vieira et al., "Production of Single-Stranded Plasmid DNA" Methods in Enzymol. 153, 3-11 (1987). |
Vlasuk, et al., "Structural and Functional Characterization of Tick Anticoagulant Peptide (TAP): A Potent and Selective Inhibitor of Blood Coagulation Factor Xa" Thromb. Haemostas. 70(1):212-216 (1993). |
Vrijsen et al., "Resolution of the Major Poliovirus Polypeptides into Doublets" Virology, 86:546-555 (1978). |
Waxman et al., "Tick Anticoagulant Peptide (TAP) Is a Novel Inhibitor of Blood Coagulation Factor Xa" Science 248:593-596 (1990). |
Weitz et al., "New Anticoagulant Strategies" J. Lab. Clin. Med. 122(4):364-373 (1993). |
Zell et al., "DNA Mismatch--Repair in Escherichia Coli Counteracting the Hydrolytic Deamination of 5-Methyl-Cytosine Residues" Embo J., 6(6):1809-1815 (1987). |
Hotez and Pritchard, "Hookworm Infection", Sci.Am., Jun. 1995, pp. 68-74. |
Cappello et al., "Ancylostoma caninum anticoagulant peptide: cloning by PCR and expression of soluble, active protein in E. coli", Molec. Biochem. Parasitol. 80:113-117 (1996). |
Jespers et al., "Surface Expression and Ligand-Based Selection of cDNAs Fused to Fileamentous Phage Gene VI", Bio/Technology 13:378-382 (1995). |
Jock Friedly, "New Anticoagulant Prompts Bad Blood Between Partner", Science 271:1800-1801 (1996). |
May 10, 1996 letter from David Kabakoff to Science; not published. |
May 13, 1996 fax from Yale University to Corvas including letter (May 10, 1996) said to have been sent to Science; not published. |
Jul. 16, 1996 e-mail from Science to Jean Ellis noting receipt of May 10, 1996 Kabakoff letter. |
Sep. 17, 1996 e-mail from Science to Jean Ellis noting Science decision to not publish May 10, 1996 Kabakoff letter. |
Sep. 26, 1996 letter from Randall Woods to Science; not published. |
Apr. 21, 1995 letter from George Vlasuk to Thrombosis and Haemostasis; not published. |