Patent Application
20130297055
1. Field of the Invention
The present invention described herein relates generally to a method and system for controlling a whole flow production process in pharmaceutical, metallurgy, food, cosmetics, and aerospace industry enterprises, and in particular, to a network-based control system designed to control whole flow pharmaceutical production process in pharmaceutical enterprises.
2. Description of the Related Art
In a pharmaceutical production facility, there are many factors affecting the quality of pharmaceutical products, as the pharmaceutical regulation of pharmaceutical products quality is stricter and the role of medicine in health care is greater than before. Due to the complicated procedures in pharmaceutical drug production, finished product quality issues or accidents may arise if the pharmaceutical companies don't reinforce the management of quality.
Nowadays, despite equipment used in production process have been improved to relatively high level, the association among the various equipments are still in a low deficiency, which often results in the information of the equipment are isolated from each other and is not beneficial for the corresponding manager to obtain particular information and to take positive measures. During a production process, the manufacturing steps are closely linked and directly and indirectly affect each other. Due to the variable factors which may have a negative effect on the quality of product are too much, there is a need to introduce the conception that integrating all the manufacturing steps and information of equipment to be control into a system, which enable the manufacturing process to run smoothly and sequentially. The quality of the product quality involves all aspects of the production, quality control, warehousing, and throughout the entire production process. Controlling measures should be taken throughout the entire production process and, and involving various concrete production equipment. On the basis of desire for controlling the whole manufacturing process, the connection between field equipments and enterprise management platform should be established, which enable data and information related to the production process to be shared seamlessly, and enable the manufacturing process run smoothly and quality control measures can be based on the data acquired by the system in a standard way.
With the development of industrialization, a pharmaceutical production plant is usually located far away from a plant control room, and meanwhile some enterprises have established their production bases in different cities, so that the traditional control technology cannot meet the requirements of real-time management and control among various production bases, which arouse the need for a system aimed at monitoring and controlling the production process even in thousands of miles away via web-based user terminals.
In summary, it is necessary to develop a set of web-based monitoring and managerial methods and systems which are closely linked with the whole process of the production, integrating the requirements of good manufacturing practice (GMP) and realizing the goal of the monitoring and management on the operating status of the production equipment in the production process, the date acquisition after the detection of quality inspection apparatus, warehouse, and the recording of production-related environmental parameters.
In 1970s, with the LSI making a breakthrough and the proliferation of 8-bit microprocessor, dramatic changes have taken place in the automation instrument industry, among which the centralized computer control system originally at crossroads, immediately absorbed microprocessor technology and became what is now called the computer distributed control system (DCS), also known as distributed control systems which adopted the method of decentralized control, centralized operation and management at different levels, sub-autonomy and comprehensive coordination.
Field bus control system (FCS) approaching the practical use since the 1990s, is developing rapidly and vigorously. And now Field bus control system is a hot topic in the current automation technology, and therefore is increasingly attracting the attention of domestic and foreign automation equipment manufacturers and its target users. The emergence of the Field bus control system will bring another revolution in the field of automation and its depth and breadth will surpass any previous one, thus creating a new era of automation. With the use of field bus, the users can significantly reduce field wiring, achieve multi-variable communication by a single field instrument, interoperate between devices of different factory production and the field-level control functions are increased, system integration is greatly simplified and its maintenance becomes very simple.
Field bus is an industry data bus newly-developed in recent years, which is mainly used for solving the problem of digital communications of on-site facilities such as intelligent instrumentation, controllers, and the implementing agencies, and problems existing in the information transfer between on-site control equipment and advanced control system. So the field bus is both a communications network and self-control network.
An aspect of the present invention is to substantially solve at least the above problems and/or disadvantages and to provide at least the advantages below. In order to solve the mentioned-above problems, the present invention, through a distributed control system (DCS) and field bus control system (FCS), adopts new generation technology to solve these problems. Accordingly, one aspect of the present invention is to provide a network-based control method and system for controlling a whole-flow production process.
According to one aspect of the present invention, there is provided a network-base control system for controlling a whole-flow production process. The system includes a first production equipment; an inspection equipment; a warehouse controlling instrument designed to collect or monitor some elements concerning warehouse; an environmental parameter controlling instrument for collecting and monitoring variable environment elements; a input/output (I/O) cabinet connected to the first production equipment, the inspection equipment, the warehousing controlling instrument, environmental parameter controlling instrument; a programmable logic controller (PLC) cabinet connected to the I/O cabinet; a switch for connecting the PLC control cabinet with a manufacturing execution systems (MES) server; and a terminal connected to the manufacturing execution systems (MES) server via a communications network.
According to one embodiment of the present invention, the system also includes an enterprise resource planning (ERP) and a quality management execution system (QMES) server connected to the MES server wherein a terminal can access, extract, transfer and control data and programs from the ERP and QMES server, and the ERP and QMES server includes ERP and QMES software.
According to one embodiment of the present invention, the ERP system includes an accounting, human resource (HR), purchasing, project management, and sales and budgeting system.
According to one embodiment of the present invention, QMES system includes software comprising Quality-by-Design (QBD), materials repository planning (MRP), manufacturing execution system (MES) and laboratory inspection management system (LIMS) system software.
According to one embodiment of the present invention, the system also includes production equipment having specific type of interface connection which can be linked to the switch directly and without connecting to the I/O cabinets and PLC cabinets, wherein the specific type of interface connection port include: RS232, RS485 and RJ45 connectors.
According to one embodiment of the present invention, the production equipments having specific type of interface connection for communicating with a high-performance liquid chromatography (HPLC), UV spectrophotometers (GC), or electronic scales.
According to one embodiment of the present invention, the system includes two PLC controller cabinets comprising a running controller cabinet and a redundant PLC controller cabinet.
According to one embodiment of the present invention, the network communications associated the terminal with manufacturing execution systems server is a way of Ethernet or wireless LAN or cloud computing.
According to yet another embodiment of the present invention, production equipment includes high efficiency wet granulation machines, tablet presses, coating machines and a reactor; and wherein the inspection equipment includes a chemical and biological incubator, a mold incubator and a moisture analyzer, wherein the warehouse controlling instrument includes humidity sensors, humidity actuators, temperature sensors and temperature actuators.
According to still another aspect of the present invention, there is provided a web-based automation control method for controlling a whole flow production process. The method includes connecting an input/output (I/O) cabinet, a production equipment, inspection equipment, a warehousing controlling instruments, an environmental parameter controlling instrument; connecting a programmable logic controller (PLC) cabinet to the input/output (I/O) cabinet; connecting a PLC cabinet to a manufacturing execution system (MES) server; and connecting a terminal to a manufacturing execution systems (MES) server via an Internet network connection.
According to still another aspect of the present invention, there is provided a web-based automation control method for controlling a whole flow production process. The method includes connecting a plurality of input/output (I/O) cabinets to a first production equipment, an inspection equipment, a warehousing controlling instrument, and an environmental parameter controlling instrument; connecting a plurality of programmable logic controller (PLC) cabinets connected to the input/output (I/O) cabinets; connecting a switch between the programmable logic controller (PLC) cabinets and a manufacturing execution systems (MES) server, connecting a plurality of terminals to the manufacturing execution systems (MES) server via an Internet communications network.
The present invention provides the following advantages:
1. The present invention takes the different production equipment used by the various pharmaceutical companies in their production process, and the different production conditions and makes the necessary changes in production accordingly and combines the distributed control system (DCS) and the field bus control system (FCS) to make the most of the advantages of their respective features.
2. Through the use of a field I/O cabinet, an analog signal is converted into a digital signal to avoid the problem that signal strength and stability would be affected because of the long transmission line. Using an I/O cabinet can solve the problem of integrating diffusing-oriented equipment used in data transmitting. Based on such data conversion, digital signal may be transmitted to a PLC control cabinet in a production line, effectively saving the use of transmission cables.
3. By using a set of redundant PLCs in a control cabinet, if one PLC malfunctions, a second PLC is available as an immediate and seamless replacement.
4. Communication conversion modules from Netorus produced by weighing equipment such as electronic weighing scales, electronic scales will transfer the data to the switch after weighing stuff.
5. The means of communication between a terminal and a server network is via an Industrial Ethernet or wireless network or cloud-based network, so as to better manage and control equipment, measuring instruments, and production plant parameters remotely.
The above and other objects, features and advantages of the present invention will become more apparent from the following detailed description when taken in conjunction with the accompanying drawings in which:
Preferred embodiments of the present invention will be described herein below with reference to the accompanying drawings. In the following description, well-known functions or constructions are not described in detail since they would obscure the invention in unnecessary detail.
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Advantageously, in one embodiment of the present invention, the enterprise resource planning (ERP) system, manufacture executive system (MES) and field bus control system (FCS) are all shown effectively integrated. The operation status of a plant production process can be easily displayed on a terminal user-interface which allows users, such production managers and personnel, to quickly and conveniently monitor the entire production process on-site or online and to quickly analyze automatically acquired production data. In the case of pharmaceutical drug production and manufacturing, for example, the drug production and overall quality can be effectively controlled by an fully automated and computerized process control system (PAT).
Alternate embodiments of the present invention can also comprise computer readable codes on a computer readable medium. The computer readable medium includes any data storage device that can store data that can be read by a computer system. Examples of a computer readable medium include magnetic storage media (such as ROM, floppy disks, and hard disks, among others), optical recording media (such as CD-ROMs or DVDs), and storage mechanisms such as carrier waves (such as transmission through the Internet). The computer readable medium can also be distributed over network coupled computer systems so that the computer readable code is stored and executed in a distributed fashion. Also, functional programs, codes, and code segments for accomplishing the present invention can be construed by programmers of ordinary skill in the art to which the present invention pertains.
While the invention has been shown and described with reference to certain preferred embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. Therefore, the scope of the invention is defined not by the detailed description of the invention but by the appended claims, and all differences within the scope will be construed as being included in the present invention.
