Neurospora Secretion Expression Vector Development

Information

• NSF Award
• 9160750

Owner

• Hawaii Biotechnology Group Inc

• Award Id

  9160750

• Award Effective Date

  1/1/1992 - 32 years ago

• Award Expiration Date

  9/30/1992 - 32 years ago

• Award Amount

  $ 50,000.00

• Award Instrument

  Standard Grant

Production of recombinant products of pharmaceutical and industrial importance in a variety of microorganisms has yielded a wide variety of biologically active proteins. Fungi offer the advantage of reduced culturing and downstream processing cost because they are capable of secreting prodigious quantities of protein. The genetics and biochemistry of Neurospora crassa are the most fully characterized of the filamentious fungi. The development of a high activity, efficient secretion expression vector system for N. crassa will facilitate efficient production of heterologous proteins in this fungus. This proposal aims to identify and clone an abundantly secreted native protein of N. crassa and characterize its promoter and secretion signal. The new N. crassa expression and secretion vectors capable of producing high levels of secreted recombinant proteins.

• Program Officer

  Ritchie B. Coryell

• Min Amd Letter Date

  1/29/1992 - 32 years ago

• Max Amd Letter Date

  1/29/1992 - 32 years ago

• ARRA Amount

• Name

  Hawaii Biotechnology Group Inc

• City

  Aiea

• State

  HI

• Country

  United States

• Address

  99-193 Aiea Heights Drive

• Postal Code

  967013911

• Phone Number

  8089488838

• First Name

  Eileen

• Last Name

  Nakano

• Start Date

  1/1/1992 12:00:00 AM

• Name

  Life Science Biological

• Code

  61