Claims
- 1. A sterile pharmaceutical composition for parenteral administration which comprises N.sup.G -monomethyl-L-arginine hydrochloride with a pharmaceutically acceptable carrier.
- 2. A sterile pharmaceutical composition for parenteral administration which comprises N.sup.G -monomethyl-L-arginine hydrochloride buffered to its own pKa in a pharmaceutically acceptable carrier.
- 3. An ampoule or vial containing a sterile aqueous solution for parenteral administration of N.sup.G -monomethyl-L-arginine hydrochloride.
- 4. An ampoule or vial containing lyophilized N.sup.G -monomethyl-L-arginine hydrochloride.
- 5. A method of treating septic shock comprising parenterally administering to a patient in need of same a therapeutically effective amount of a sterile pharmaceutical composition which comprises N.sup.G -monomethyl-L-arginine hydrochloride in a pharmaceutically acceptable carrier.
- 6. The method of claim 5 in which the composition is administered by injection at a dose of 1 to 100 mg/kg per day.
- 7. The method of claim 6 in which the composition is administered by injection at a dose of 3 to 50 mg/kg per day.
Priority Claims (2)
Number |
Date |
Country |
Kind |
9215816.1 |
Jul 1992 |
GBX |
|
PCTGB9301563 |
Jul 1993 |
WOX |
|
Parent Case Info
This is a division of application Ser. No. 08/862,468, filed May 23, 1997, now U.S. Pat. No. 5,767,312 which is a Continuation of Ser. No. 08/461,163, filed Jun. 5, 1995, now abandoned; which is a continuation of Ser. No. 08/374,636, filed Jan. 23, 1995, now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
5225440 |
London |
Jul 1993 |
|
5374651 |
Kilbourn |
Dec 1994 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
WO 9104024 |
Apr 1991 |
WOX |
Non-Patent Literature Citations (6)
Entry |
Vogel "A Textbook of Practical Organic Chemistry" 3.sup.rd Ed., pp 122-136, 1956. |
Kilbourn et al Proc. Natl. Acad. Sci. USA; vol. 87, pp. 3629-3632; May 1990 NG-Methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: Implications for the involvement of nitric oxide. |
European Search Report PCT/GB93/01563. |
Prabhakaran et al J.Am. Chem. Soc. 1988, 110, 5785-5791 Biosynthesis of Blasticidin S from L-.alpha.-Arginine etc. |
546C88 for Septic Shock -Study termination Apr. 24, 1998 London. |
Scrip Display Apr. 27, 1998 Glaxo Wellcome hits problems in sepsis. |
Divisions (1)
|
Number |
Date |
Country |
Parent |
862468 |
May 1997 |
|
Continuations (2)
|
Number |
Date |
Country |
Parent |
461163 |
Jun 1995 |
|
Parent |
374636 |
Jan 1995 |
|