Claims
- 1. A compound of formula I:
- 2. The compound of claim 1 wherein R1 is nitro or NRaRb.
- 3. The compound of claim 1 wherein R1 is nitro.
- 4. The compound of claim 1 wherein R1 is NRaRb.
- 5. The compound of claim 1 wherein R2 is hydrogen, or ORd, wherein each Rd is hydrogen or (C1-C6)alkyl.
- 6. The compound of claim 1 wherein R2 is hydrogen.
- 7. The compound of claim 1 wherein R2 is nitro or NRaRb.
- 8. The compound of claim 1 wherein R2 is nitro.
- 9. The compound of claim 1 wherein R2 is NRaRb.
- 10. The compound of claim 1 wherein R1 is hydrogen, or ORd, wherein each Rd is hydrogen or (C1-C6)alkyl.
- 11. The compound of claim 1 wherein R1 is hydrogen.
- 12. The compound of claim 1 wherein R3 is nitro or NRaRb.
- 13. The compound of claim 1 wherein R3 is nitro.
- 14. The compound of claim 1 wherein R3 is NRaRb.
- 15. The compound of claim 1 wherein R4 is hydrogen, or ORd, wherein each Rd is hydrogen or (C1-C6)alkyl.
- 16. The compound of claim 1 wherein R4 is hydrogen.
- 17. The compound of claim 1 wherein R4 is nitro or NRaRb.
- 18. The compound of claim 1 wherein R4 is nitro.
- 19. The compound of claim 1 wherein R4 is NRaRb.
- 20. The compound of claim 1 wherein R3 is hydrogen, or ORd, wherein each Rd is hydrogen or (C1-C6)alkyl.
- 21. The compound of claim 1 wherein R3 is hydrogen.
- 22. The compound of claim 1 wherein R3 and R4 taken together are methylenedioxy, 1,2-ethylenedioxy, or 1,3-propylenedioxy.
- 23. The compound of claim 1 wherein R3 and R4 taken together are methylenedioxy.
- 24. The compound of claim 1 wherein R1 and R2 taken together are methylenedioxy, 1,2-ethylenedioxy, or 1,3-propylenedioxy.
- 25. The compound of claim 1 wherein R1 and R2 are each independently ORd, wherein each Rd is hydrogen or (C1-C6)alkyl.
- 26. The compound of claim 1 wherein R1 and R2 are each methoxy.
- 27. The compound of claim 1 wherein R5 is (C1-C6)alkyl substituted with one or more hydroxy groups.
- 28. The compound of claim 1 wherein R5 is (C1-C6)alkyl substituted with one hydroxy group.
- 29. The compound of claim 1 wherein R5 is (C1-C6)alkyl substituted with one or more mercapto groups.
- 30. The compound of claim 1 wherein R5 is (C1-C6)alkyl substituted with one mercapto group.
- 31. The compound of claim 1 wherein R5 is (C1-C6)alkyl substituted with one or more carboxy groups.
- 32. The compound of claim 1 wherein R5 is (C1-C6)alkyl substituted with one carboxy group.
- 33. The compound of claim 1 wherein R5 is (C1-C6)alkyl substituted with one or more NRfRg groups.
- 34. The compound of claim 1 wherein R5 is (C1-C6)alkyl substituted with one NRfRg group.
- 35. The compound of claim 1 wherein R5 is (C1-C6)alkyl substituted with one or more NH2 groups.
- 36. The compound of claim 1 wherein R5 is a (C1-C6)alkyl substituted with one NH2 group.
- 37. The compound of claim 1 wherein R5 is (C1-C6)alkyl substituted with one or more N(CH3)2 groups.
- 38. The compound of claim 1 wherein R5 is a (C1-C6)alkyl substituted with one N(CH3)2 group.
- 39. The compound of claim 1 wherein R5 is (C1-C6)alkyl substituted with one or more N(CH2CH3)2 groups.
- 40. The compound of claim 1 wherein R5 is a (C1-C6)alkyl substituted with one N(CH2CH3)2 group.
- 41. The compound of claim 1 wherein R5 is a (C1-C6)alkyl substituted with one or more (C1-C6)alkoxycarbonyl, cyano, halo, hydroxy, mercapto, oxo, carboxy, nitro, pyrrolidinyl, piperidinyl, imidazolidinyl, imidazolinyl, piperazinyl, morpholinyl, thiomorpholinyl, or —NRfRg groups, wherein Rf and Rg may be the same or different and are chosen from hydrogen, (C1-C6)alkyl, and (C3-C6)cycloalkyl.
- 42. The compound of claim 1 wherein R5 is a (C2-C4)alkyl substituted with one or two groups selected from hydroxy, mercapto, carboxy, amino, methylamino, ethylamino, dimethylamino, and diethylamino.
- 43. The compound of claim 1 wherein R5 is 2-hydroxyethyl.
- 44. The compound of claim 1 wherein R5 is 3-hydroxypropyl.
- 45. The compound of claim 1 wherein R5 is 2-hydroxypropyl.
- 46. The compound of claim 1 wherein R5 is —CH2CH2—NRfRg or —CH2CH2CH2—NRfRg wherein Rf and Rf are each independently hydrogen or (C1-C6)alkyl.
- 47. The compound of claim 1 wherein R5 is —CH2CH2—NRfRg or —CH2CH2CH2—NRfRg wherein Rf and Rf are each independently methyl or ethyl.
- 48. The compound of claim 1 wherein R1 is hydrogen; R2 is nitro; and R3 and R4 taken together are methylenedioxy.
- 49. The compound of claim 1 wherein R1 is nitro; R2 is hydrogen; and R3 and R4 taken together are methylenedioxy.
- 50. The compound of claim 1 wherein R1 and R2 are each methoxy; R3 is nitro; and R4 is hydrogen.
- 51. The compound of claim 1 wherein R1 and R2 are each methoxy; R3 is hydrogen; and R4 is nitro.
- 52. The compound of claim 1 wherein R1 is hydrogen; R2 is nitro; and R3 and R4 are each methoxy.
- 53. The compound of claim 1 wherein R1 is nitro; R2 is hydrogen; and R3 and R4 are each methoxy.
- 54. The compound of claim 1 wherein R1 and R2 taken together are methylenedioxy; R3 is nitro; and R4 is hydrogen.
- 55. The compound of claim 1 wherein R1 and R2 taken together are methylenedioxy; R3 is hydrogen; and R4 is nitro.
- 56. The compound of claim 1 wherein the compound of formula (I) is a compound of formula (II):
- 57. The compound of claim 1 wherein the compound of formula (I) is a compound of formula (III):
- 58. Any one of compounds 4a, 4b, 8a, and 8b wherein R5 is 2-(N,N-dimethylamino)ethyl, 2-(N,N-dimethylamino)propyl, 2-( N,N-diethylamino)ethyl, or 2-(N,N-diethylamino)propyl or a pharmaceutically acceptable salt thereof.
- 59. A pharmaceutical composition comprising a compound as described in claim 1 in combination with a pharmaceutically acceptable diluent or carrier.
- 60. A method of inhibiting cancer cell growth, comprising administering to a mammal afflicted with cancer, an amount of a compound as described in claim 1, effective to inhibit the growth of said cancer cells.
- 61. A method comprising inhibiting cancer cell growth by contacting said cancer cell in vitro or in vivo with an amount of a compound as described in claim 1, effective to inhibit the growth of said cancer cell.
- 62. A method of producing an antibacterial effect in a mammal in need of such treatment comprising administering to the mammal, an amount of a compound as described in claim 1, effective to provide an antibacterial effect.
- 63. A method of producing an antifungal effect in a mammal in need of such treatment comprising administering to the mammal, an amount of a compound as described in claim 1, effective to provide an antifungal effect.
PRIORITY OF INVENTION
[0001] This application claims priority to U.S. Provisional Patent Application No. 60/402166, filed Aug. 19, 2002.
GOVERNMENT FUNDING
[0002] The invention described herein was made with government support under Grant Numbers CA39662 and CA077433 from the National Cancer Institute. The United States Government has certain rights in the invention.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60402166 |
Aug 2002 |
US |