Claims
- 1. A compound of formula I:
- 2. The compound of claim 1 wherein W is N.
- 3. The compound of claim 1 wherein W is CH.
- 4. The compound of claim 1 wherein R1 is nitro.
- 5. The compound of claim 1 wherein R1 is NRaRb.
- 6. The compound of claim 1 wherein R2 and R3 are each independently hydrogen, or ORd, wherein each Rd is hydrogen or (C1-C6)alkyl.
- 7. The compound of claim 1 wherein R2 and R3 are each hydrogen.
- 8. The compound of claim 1 wherein R2 is nitro or NRaRb.
- 9. The compound of claim 1 wherein R2 is nitro.
- 10. The compound of claim 1 wherein R2 is NRaRb.
- 11. The compound of claim 1 wherein R1 and R3 are each independently hydrogen, or ORd, wherein each Rd is hydrogen or (C1-C6)alkyl.
- 12. The compound of claim 1 wherein R1 and R3 are each hydrogen.
- 13. The compound of claim 1 wherein R3 is nitro or NRaRb.
- 14. The compound of claim 1 wherein R3 is nitro.
- 15. The compound of claim 1 wherein R3 is NRaRb.
- 16. The compound of claim 1 wherein R1 and R2 are each independently hydrogen, or ORd, wherein each Rd is hydrogen or (C1-C6)alkyl.
- 17. The compound of claim 1 wherein R1 and R2 are each hydrogen.
- 18. The compound of claim 1 wherein R4 is hydrogen.
- 19. The compound of claim 1 wherein R4 is fluoro or hydroxy.
- 20. The compound of claim 1 wherein one of R2 and R3 is nitro or NRaRb.
- 21. The compound of claim 1 wherein each R5, R6, R7, and R8 is independently hydrogen, or ORd.
- 22. The compound of claim 1 wherein R5 is hydrogen.
- 23. The compound of claim 1 wherein each R6 ORd.
- 24. The compound of claim 1 wherein each R7 ORd.
- 25. The compound of claim 1 wherein each R8 is hydrogen.
- 26. The compound of claim 1 wherein R5 and R6 taken together are methylenedioxy, 1,2-ethylenedioxy, or 1,3-propylenedioxy.
- 27. The compound of claim 1 wherein R6 and R7 taken together are methylenedioxy, 1,2-ethylenedioxy, or 1,3-propylenedioxy.
- 28. The compound of claim 1 wherein R7 and R8 taken together are methylenedioxy, 1,2-ethylenedioxy, or 1,3-propylenedioxy.
- 29. The compound of claim 1 wherein R9 is (C1-C6)alkyl substituted with one or more hydroxy groups.
- 30. The compound of claim 1 wherein R9 is (C1-C6)alkyl substituted with one hydroxy group.
- 31. The compound of claim 1 wherein R9 is (C1-C6)alkyl substituted with one or more mercapto groups.
- 32. The compound of claim 1 wherein R9 is (C1-C6)alkyl substituted with one mercapto group.
- 33. The compound of claim 1 wherein R9 is (C1-C6)alkyl substituted with one or more carboxy groups.
- 34. The compound of claim 1 wherein R9 is (C1-C6)alkyl substituted with one carboxy group.
- 35. The compound of claim 1 wherein R9 is (C1-C6)alkyl substituted with one or more NRfRg groups.
- 36. The compound of claim 1 wherein R9 is (C1-C6)alkyl substituted with one NRfRg group.
- 37. The compound of claim 1 wherein R9 is (C1-C6)alkyl substituted with one or more NH2 groups.
- 38. The compound of claim 1 wherein R9 is a (C1-C6)alkyl substituted with one NH2 group.
- 39. The compound of claim 1 wherein R9 is (C1-C6)alkyl substituted with one or more N(CH3)2 groups.
- 40. The compound of claim 1 wherein R9 is a (C1-C6)alkyl substituted with one N(CH3)2 group.
- 41. The compound of claim 1 wherein R9 is (C1-C6)alkyl substituted with one or more N(CH2CH3)2 groups.
- 42. The compound of claim 1 wherein R9 is a (C1-C6)alkyl substituted with one N(CH2CH3)2 group.
- 43. The compound of claim 1 wherein R9 is a (C1-C6)alkyl substituted with one or more (C1-C6)alkoxycarbonyl, cyano, halo, hydroxy, mercapto, oxo, carboxy, nitro, pyrrolidinyl, piperidinyl, imidazolidinyl, imidazolinyl, piperazinyl, morpholinyl, thiomorpholinyl, or —NRfRg groups, wherein Rf and Rg may be the same or different and are chosen from hydrogen, (C1-C6)alkyl, and (C3-C6)cycloalkyl.
- 44. The compound of claim 1 wherein R9 is a (C2-C4)alkyl substituted with one or two groups selected from hydroxy, mercapto, carboxy, amino, methylamino, ethylamino, dimethylamino, and diethylamino.
- 45. The compound of claim 1 wherein R9 is 2-hydroxyethyl.
- 46. The compound of claim 1 wherein R9 is 3-hydroxypropyl.
- 47. The compound of claim 1 wherein R9 is 2-hydroxypropyl.
- 48. The compound of claim 1 wherein R9 is —CH2CH2—NRfRg wherein Rf and Rf are each independently hydrogen or (C1-C6)alkyl.
- 49. The compound of claim 1 wherein R9 is —CH2CH2—NRfRg wherein Rf and Rf are each independently methyl or ethyl.
- 50. Any one of compounds 4a, 4b, 5a, 5b, 6a, and 6b; or a pharmaceutically acceptable salt thereof.
- 51. The compound of claim 1 wherein R1 is hydrogen; R2 is nitro; R3 is hydrogen; R4 is hydrogen; R5 is hydrogen; R6 and R7 taken together are methylenedioxy; R8 is hydrogen; R9 is 2-(N,N-dimethylamino)ethyl or 2-(N,N-diethylamino)ethyl; W is N or CH; and X is ═O; or a pharmaceutically acceptable salt thereof.
- 52. The compound of claim 1 wherein R1 is hydrogen; R2 is hydrogen; R3 is nitro; R4 is hydrogen; R5 is hydrogen; R6 and R7 taken together are methylenedioxy; R8 is hydrogen; R9 is 2-(N,N-dimethylamino)ethyl or 2-(N,N-diethylamino)ethyl; W is N or CH; and X is ═O; or a pharmaceutically acceptable salt thereof.
- 53. A pharmaceutical composition comprising a compound as described in claim 1 in combination with a pharmaceutically acceptable diluent or carrier.
- 54. A method of inhibiting cancer cell growth, comprising administering to a mammal afflicted with cancer, an amount of a compound as described in claim 1, effective to inhibit the growth of said cancer cells.
- 55. A method comprising inhibiting cancer cell growth by contacting said cancer cell in vitro or in vivo with an amount of a compound as described in claim 1, effective to inhibit the growth of said cancer cell.
- 56. A method of producing an antibacterial effect in a mammal in need of such treatment comprising administering to the mammal, an amount of a compound as described in claim 1, effective to provide an antibacterial effect.
- 57. A method of producing an antifungal effect in a mammal in need of such treatment comprising administering to the mammal, an amount of a compound as described in claim 1, effective to provide an antifungal effect.
PRIORITY OF INVENTION
[0001] This application claims priority to U.S. Provisional Patent Application No. 60/402,138, filed Aug. 09, 2002.
GOVERNMENT FUNDING
[0002] The invention described herein was made with government support under Grant Numbers CA39662 and CA077433 from the National Cancer Institute. The United States Government has certain rights in the invention.
Provisional Applications (1)
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Number |
Date |
Country |
|
60402138 |
Aug 2002 |
US |