Claims
- 1. Compounds of the formula ##STR14## wherein the radicals R.sub.1 and R.sub.2 are the same or different and represent hydrogen, halogen atoms, a trifluoromethyl group, a cyano group, a nitro group, an amino group, a mono-C.sub.1 -C.sub.6 -alkylamino group, a di-C.sub.1 -C.sub.6 -alkylamino group, an amino group that is substituted by a phenyl-C.sub.1 -C.sub.4 -alkyl radical or a halogenphenyl-C.sub.1 -C.sub.4 -alkyl radical, a C.sub.2 -C.sub.6 -alkanoylamino group, a C.sub.1 -C.sub.6 -alkoxycarbonylamino group, a C.sub.1 -C.sub.6 -alkyl group optionally substituted by a phenol radical, a hydroxy group, a C.sub.1 -C.sub.6 -alkoxy group, a C.sub.2 -C.sub.6 -alkanoyloxy group, a phenoxy group or a carbamoyl group optionally substituted by one or two C.sub.1 -C.sub.6 -alkyl groups, the radical A represents the group ##STR15## wherein R.sub.3 is hydrogen, a phenyl radical, an indolyl-(3)-methyl radical, imidazolyl-(4)-methyl radical, a C.sub.1 -C.sub.10 -alkyl group, or wherein R.sub.3 represents a C.sub.1 -C.sub.10 alkyl group which is substituted by a carboxy group, a C.sub.1 -C.sub.6 -alkoxycarbonyl group, an aminocarbonyl group, a hydroxy group, a C.sub.1 -C.sub.6 -alkoxy group, a C.sub.2 -C.sub.6 -alkanoyloxy group, a mercapto group, a C.sub.1 -C.sub.6 -alkylthio group, a C.sub.2 -C.sub.6 -alkanoyl mercapto group, a phenol group, a hydroxyphenyl group, a dihydroxyphenyl group, an amino-C.sub.1 -C.sub.6 -alkylthio group, an amino-C.sub.1 -C.sub.6 -alkyloxy group, an amino group, a ureido group (H.sub.2 NCONH--) or a quanidino group or where R.sub.3 together with the structural portion >CH(NHR.sub.4) represents the pyrrolidine-2-yl radical (proline radical) or the 4-hydroxy-pyrrolidine-2-yl radical, R.sub.4 is hydrogen, benzyl or a C.sub.1 -C.sub.6 -alkyl radical, R.sub.5 is hydrogen, benzyl, a C.sub.1 -C.sub.6 -alkyl radical, a C.sub. 2 -C.sub.6 -alkanoyl radical or the group ##STR16## wherein R.sub.3 and R.sub.4 have the meanings stated above and R.sub.6 is hydrogen, benzyl or C.sub.2 -C.sub.6 -alkanoyl, X is oxygen, sulphur, SO or SO.sub.2, Alk is a direct bond or alkylene with 1-4 carbon atoms and n and m are the same or different and can represent the numbers 1-3, provided that n can also be 0 when Alk is alkylene and m represents in this case the numbers 2-6, their pyridine-N-oxides and/or aminooxides or a pharmaceutically-acceptable salt thereof.
- 2. A pharmaceutically composition which contains, as active ingredient, an effective amount of at least one compound according to claim 1 together with a conventional pharmaceutical carrier and/or diluent.
- 3. A method of treating a patient in need of analgesic, pain relieving or anti-depressant treatment, which comprises administering an effective amount of a compound according to claim 1.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3713246 |
Apr 1987 |
DEX |
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Parent Case Info
This is a continuation on Ser. No. 182,662, filed 4/18/88, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4643995 |
Engel et al. |
Feb 1987 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
182662 |
Apr 1988 |
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