Claims
- 1. Method of radiosensitizing hypoxic tumor cells in a warm-blooded animal with reduced neurotoxic side effects comprising administering a compound of the formula ##STR4## wherein R is hydrogen or a 2-hydroxyethyl radical to the animal systemically at a dosage level that radiosensitizes said cells.
- 2. The method of claim 1 wherein the animal is a human, the administration is intravenous and in a fractionation regime with the total dose not exceeding about 120 g/m.sup.2.
- 3. The method of claim 2 wherein the regime is weekly doses for up to six weeks and the individual dose is in the range of about 2 to about 20 g/m.sup.2.
- 4. The method of claim 2 wherein the regime is daily doses for up to six weeks and the individual doses are in the range of about 0.5 to about 5 g/m.sup.2.
- 5. The method of claim 2 or claim 3 wherein the compound is administered intravenously about one-half to about one hour before said cells are exposed to radiation.
- 6. The method of claim 1 wherein the administration is oral and the compound is in the form of a prodrug that passes through the gastrointestinal barrier of the animal more rapidly than the compound and converts to the compound once in the circulatory system of the animal, and wherein the prodrug is the acetate ester of the compound.
CROSS REFERENCE TO RELATED APPLICATION
This application is a continuation-in-part of copending U.S. application Ser. No. 75,603 filed Sept. 14, 1979, now abandoned.
DESCRIPTION
The invention described herein was made in the course of or under Contract No. NO1-CM-87207 with the U.S. Dept. of Health, Education and Welfare.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3679698 |
Beaman et al. |
Jul 1972 |
|
Non-Patent Literature Citations (4)
Entry |
Asquith et al., Radiation Research 1974, vol. 60, pp. 108-118. |
Hall et al., British Journal of Cancer 1978, vol. 37, Suppl. III, pp. 120-123. |
Dische et al., British Journal of Cancer 1977, vol. 35, pp. 567-579. |
Brown et al., Radiation Research 1980, vol. 82, pp. 171-190. |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
75603 |
Sep 1979 |
|