Claims
- 1. A compound having the formula I: or a pharmaceutically acceptable salt thereof, wherein RX is selected from the group consisting of: C(CH2F)3, and C(CH2F)2CH3; or RX is a 1,1-dimethylpropyl, 1,1-dimethylprop-2-enyl, 3,4,4-trichlorobut-3-enyl, 1,1,2-trimethylprop-2-enyl, 1,1-dimethyl-2-trifluoromethylprop-2-enyl, 3-methyoxypropyl, 1,1-dimethylbutyl, 4,4,4-trifluorobutyl, 2,2,3,3,3-pentafluoropropyl, 3,3,4,4,4-pentafluorobutyl, 5,5,5-trifluoropentyl, 1-fluoromethyl-2-fluoroethyl, 1-methyl-2,2,2-trifluoroethyl, 2-fluoromethyl-3-fluoropropyl, 1,1-dimethyl-2,2,2-trifluoroethyl, 2,2-difluoropropyl, 3,3,3-difluorobutyl, 2,2-difluorobutyl, 2-methyl-3,3,3-trifluoropropyl, 2,2,3,3,4,4,4-heptofluorobutyl, 2,2-difluoro-3-methylbutyl, 2-methyl-3,3,3-trifluoropropyl, 3-methylbutyl, 1,1-dimethyl-2-oxo-4,4,4-trifluorobutyl, 1,1-dimethyl-2-oxo-5,5,5-trifluoropentyl, 3,1,1,3-trimethyl-2-oxobutyl, 1,1,3,3-tetramethyl-2-oxobutyl, (propyl 2-methylpropanoate)-2yl, (isopropyl 2-methylpropanoate)-2-yl, (phenyl 2-methylpropanoate)-2-yl, 1,1 -bis(fluoromethyl)-2-oxo-4,4,4-trifluorobutyl, 1,1-bis(fluoromethyl)-2-oxo-3,3-dimethylbutyl, 2,2-bis(fluoromethyl)-(N-methyl-N-ethyl)acetamide)-2-yl, ethyl 2,2-bis(fluoromethyl)acetate)-2yl, propyl 2,2-bis(fluoromethyl)acetate)-2-yl, isopropyl 2,2-bis(fluoromethyl)acetate, phenyl 2,2-bis(fluoromethyl)acetate)-2-yl, 1,1-dimethyl-2-oxopropyl, 1,1-dimethyl-2-oxobutyl, 1,1,3-trimethyl-2-oxobutyl, α,α-dimethyl-β-oxophenethyl, or 2,3-dimethyl-3-hydroxy-2-butyl group.
- 2. A compound of claim 1 wherein RX is selected from the group consisting of:C(CH2F)3, and C(CH2F)2CH3.
- 3. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
- 4. A composition of claim 3 further comprising an anthelmintic agent.
- 5. A composition of claim 4 wherein said anthelmintic agent is selected from the group consisting of: ivermectin, avermectin 5-oxime, abamectin, emamectin, eprinamectin, doramectin, doramectin monosaccharide 5-oximes, fulladectin, milbemycin, milbamycin 5-oxime, moxidectin, Interceptor™, nemadectin, imidacloprid, fipronil, lufenuron, thiabendazole, cambendazole, parbendazole, oxibendazole, mebendazole, flubendazole, fenbendazole, oxfendazole, albendazole, cyclobendazole, febantel, thiophanate, tetramisole-levamisole, butamisole, pyrantel, pamoate, oxantel and morantel.
- 6. A composition of claim 3 further comprising fipronil, imidacloprid, lufenuron or an ecdysone agonist.
- 7. A method for the treatment or prevention of a parasitic disease in a mammal which comprises administering to said mammal an antiparasitic effective amount of a compound of claim 1.
- 8. A method of claim 7 further comprising co-administering to said mammal a therapeutically effective amount of an anthelmintic agent.
- 9. A method of claim 7 further comprising co-administering to said mammal a therapeutically effective amount of fipronil, imidacloprid or lufenuron.
Parent Case Info
This is a 371 of PCT/US97/16242, filed Sep. 15, 1997 which is a continuation-in-part of U.S. Application Ser. No. 08/716,012, filed Sep. 19, 1996, now abandoned, which is a continuation-in-part of U.S. Application Ser. No. 08/606,312, filed Mar. 11, 1996, now abandoned, which is a continuation-in-part of U.S. Application Ser. No. 08/406,619, filed Mar. 20, 1995, now abandoned.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/US97/16242 |
|
WO |
00 |
3/17/1999 |
3/17/1999 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO98/12196 |
3/26/1998 |
WO |
A |
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
5015630 |
Fisher et al. |
May 1991 |
|
5399582 |
Dombrowski et al. |
Mar 1995 |
|
5595991 |
Shoop et al. |
Jan 1997 |
|
5962499 |
Meinke et al. |
Oct 1999 |
|
Foreign Referenced Citations (13)
Number |
Date |
Country |
0 357460 |
Mar 1990 |
EP |
0 382173 |
Aug 1990 |
EP |
0 444964 |
Sep 1991 |
EP |
0 594291 |
Apr 1994 |
EP |
0 626375 |
Nov 1994 |
EP |
WO 9206582 |
Apr 1992 |
WO |
WO 9319053 |
Sep 1993 |
WO |
WO 9325543 |
Dec 1993 |
WO |
WO 9415944 |
Jul 1994 |
WO |
WO 9419334 |
Sep 1994 |
WO |
WO 9522552 |
Aug 1995 |
WO |
WO 9611945 |
Apr 1996 |
WO |
WO 9615121 |
May 1996 |
WO |
Continuation in Parts (3)
|
Number |
Date |
Country |
Parent |
08/716012 |
Sep 1996 |
US |
Child |
09/269010 |
|
US |
Parent |
08/606312 |
Mar 1996 |
US |
Child |
08/716012 |
|
US |
Parent |
08/406619 |
Mar 1995 |
US |
Child |
08/606312 |
|
US |