Claims
- 1. A sulfur containing analog of 1α,25 dihydroxy vitamin D3 selected from the group consisting of compounds represented by formulae II-X and XIV-XVII as follows:
- 2. A vitamin D3 analog according to claim 1 which is in the (+)(1β,3α) diastereomeric configuration.
- 3. A vitamin D3 analog according to claim 1 which is in the (−)(1α,3β) diastereomeric configuration.
- 4. A vitamin D3 analog which is a 23-oxa-25-sulfone represented by formula XI wherein X is H2 or F2, and R is a branched or straight chain lower alkyl, an unsubstituted phenyl group or a phenyl group substituted with a lower alkyl or alkoxy group.
- 5. The vitamin D3 analog according to claim 4 wherein R is selected from the group consisting of methyl, t-butyl, phenyl and p-methoxyphenyl.
- 6. A vitamin D3 analog which is a 20-epi-22-oxa-sulfone represented by Formula XII wherein n is 1 or 2, X is H2 or F2 and R is a branched or straight chain lower alkyl, an unsubstituted phenyl group or a phenyl group substituted with a lower alkyl or alkoxy group.
- 7. The vitamin D3 analog according to claim 6 wherein R is selected from the group consisting of methyl, t-butyl, phenyl and p-methoxyphenyl.
- 8. The vitamin D3 analog which is a 16-ene-alkenylsulfone or 16ene-alkynylsulfone represented by formula XIII wherein n is 1 or 2 and R is a branched or straight chain lower alkyl, an unsubstituted phenyl group or a phenyl group substituted with a lower alkyl or alkoxy group.
- 9. The vitamin D3 analog according to claim 8 wherein R is selected from the group consisting of methyl, t-butyl, phenyl and p-methoxyphenyl.
- 10. A vitamin D3 analog which is a 22E, 24E diene sulfone represented by formula XVIII wherein R is a branched or straight chain lower alkyl, an unsubstituted phenyl group or a phenyl group substituted with a lower alkyl or alkoxy group.
- 11. The vitamin D3 analog according to claim 10 which is in the (−)(1α,3β) diastereomeric configuration.
- 12. The vitamin D3 analog according to claim 11 wherein R is selected from the group consisting of methyl, t-butyl, phenyl and p-methoxyphenyl.
- 13. The vitamin D3 analog according to claim 11 wherein R is t-butyl.
Parent Case Info
This Application claim benefit to Provisional Application No. 60/127,328 filed Apr. 1, 1999 which claims benefit to No. 60/128,478 filed Apr. 9, 1999.
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Provisional Applications (2)
|
Number |
Date |
Country |
|
60/127328 |
Apr 1999 |
US |
|
60/128478 |
Apr 1999 |
US |