Claims
- 1. A drug composition containing an effective amount of a non-crosslinked acrylic polymer consisting of polyacryloyloxyethyl-N,N-dimethylbenzyl ammonium salt having a pH of about 4.5 to about 6.5 when 0.5 g of said polymer are dissolved in water to obtain 50 cc of a solution and a viscosity of not higher than about 150 centipoises when said polymer is dissolved in water to form a 1 wt. % aqueous solution at 25.degree. C.
- 2. A drug composition containing an effective amount of a non-crosslinked anionic exchange resin consisting of polyacryloyloxyethyl-N,N-dimethylbenzyl ammonium salt having a pH of about 4.5 to about 6.5 when 0.5 g of said polymer are dissolved in water to obtain 50 cc of a solution thereof and a viscosity of not more than about 150 centipoises when said polymer is dissolved in water to form a 1 wt. % aqueous solution thereof at 25.degree. C.
- 3. A drug composition for lowering the cholesterol content of a patient which contains as the main active component a non-crosslinked acrylic polymer according to claim 1.
- 4. A drug composition for lowering the cholesterol content of a patient which contains as the main active component a non-crosslinked anionic exchange resin according to claim 2.
- 5. A non-crosslinked acrylic anionic exchange resin which is prepared by reacting CH.sub.2 .dbd.CHCOO(CH.sub.2).sub.2 --N(CH.sub.3).sub.2 with a benzyl salt of formula C.sub.6 H.sub.5 CH.sub.2 X wherein X is chloride or bromide whereby the quaternary monomer of formula ##STR1## is obtained and then subjecting said quaternary monomer to a free radical polymerization in the presence of a azobisisobutyronitrile (AIBN) or an ammonium/persulfate sodium hydrogen sulfite for a time of from about 0.5 to about 30 hours at a temperature of 15.degree.-80 .degree. C. to obtain a reaction mixture and precipitating said anion exchange resin by addition of acetone or dioxane to said reaction mixture, said non-crosslinked acrylic anionic exchange resin having a weight average molecular weight between 163.26.times.10.sup.4 and 480.32.times.10.sup.4 and a viscosity not higher than 150 centipoises and being more effective than cholestyramine in inhibiting cholesterol increase.
- 6. The anionic exchange resin according to claim 5 which is prepared by
- 1) reacting 85.9 g (0.6 mol) of acryloyloxyethyl-N,N-dimethylamine, 160 g of acetone and 0.1 g of hydroquinone monomethyl ether, as a polymerization inhibitor, and after mixing to obtain a homogeneous mixture, adding 75.9 g (0.6 mol) of benzyl chloride to said homogeneous mixture, letting the mixture stand overnight at room temperature, washing the mixture with 500 ml of acetone whereby crystals of the monomer acryloyloxyethyl-N,N-dimethylbenzyl ammonium chloride is obtained;
- 2) dissolving 150 g of said crystals of the monomer acryloyloxyethyl-N,N-dimethylbenzyl ammonium chloride in 280 g of purified water, purging with nitrogen for 5 hours;
- 3) adding 0.01 g of 2,2'-azobis(2-amidinopropane) hydrochloride while keeping the temperature at 65.degree. C. and letting polymerization to occur for about 20 hours;
- 4) precipitating said anion exchange resin by addition of acetone.
- 7. The anionic exchange resin according to claim 6 wherein said resin has residual acetone content not more than 100 ppm, a residual monomer not more than 19 ppm, residual benzyl chloride not more than 315 ppm, benzyl alcohol not more than 233 ppm, heavy metals not more than 10 ppm, arsenic not more than 1 ppm and said quaternary ammonium salt not more than 3500 ppm.
- 8. The anionic exchange resin according to claim 7 which has weight average molecular weight of 372.34.times.10.sup.4 when measured by Gel Permeation Chromatography and a viscosity of 102.8 centipoises when measured by a rotary viscosimeter.
Priority Claims (1)
Number |
Date |
Country |
Kind |
4-24531 |
Jan 1992 |
JPX |
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Parent Case Info
This application is a continuation in part on Ser. No. 08/256,486 filed Jul. 8, 1994 and now U.S. Pat. No. 5,669,348.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3239496 |
Jursich |
Mar 1966 |
|
3661880 |
Markert et al. |
May 1972 |
|
5665348 |
Okayama et al. |
Sep 1997 |
|
Foreign Referenced Citations (3)
Number |
Date |
Country |
61-138607 |
Jun 1986 |
JPX |
62-270609 |
Nov 1987 |
JPX |
WO9118027 |
Nov 1991 |
WOX |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
256486 |
Jul 1994 |
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