NON-INVASIVE AUTONOMIC NERVOUS SYSTEM MODULATION

The disclosures of all of the above referenced applications are expressly incorporated by reference herein.

The following patent applications are also expressly incorporated by reference herein.

U.S. patent application Ser. Nos. 11/583,569, 12/762,938, 11/583,656, 12/247,969, 10/633,726, 09/721,526, 10/780,405, 09/747,310, 12/202,195, 11/619,996, 09/696,076, 11/016,701, 12/887,178, 12/390,975, 12/887,178, 12/887,211, 12/887,232, 11/583,656.

It should be noted that the subject matters of the above applications and any other applications referenced herein are expressly incorporated into this application as if they are expressly recited in this application. Thus, in the instance where the references are not specifically labeled as “incorporated by reference” in this application, they are in fact deemed described in this application.

BACKGROUND

Energy delivery from a distance involves transmission of energy waves to affect a target at a distance. It allows for more efficient delivery of energy to targets and a greater cost efficiency and technologic flexibility on the generating side. In terms of treating a patient, delivering energy over a distance affords great advantages as far as targeting accuracy, technologic flexibility, and importantly, limited invasiveness into the patient. In a simple form, laparoscopic surgery has replaced much of the previous open surgical procedures and lead to creation of new procedures and devices as well as a more efficient procedural flow for disease treatment. Laparoscopic tools deliver the surgeon's energy to the tissues of the patient from a distance and results in improved imaging of the region being treated as well as the ability for many surgeons to visualize the region at the same time.

Perhaps the most important aspect is the fact that patients have much less pain, fewer complications, and the overall costs of the procedures are lower. Visualization is improved as is the ability to perform tasks relative to the visualization.

Continued advances in computing, miniaturization and economization of energy delivery technologies, and improved imaging will lead to still greater opportunities to apply energy from a distance into the patient and treat disease.

SUMMARY

In some embodiments, procedures and devices are provided, which advance the art of medical procedures involving transmitted energy to treat disease. The procedures and devices follow along the lines of: 1) transmitting energy to produce an effect in a patient from a distance; 2) allowing for improved imaging or targeting at the site of treatment; 3) creating efficiencies through utilization of larger and more powerful devices from a position of distance from or within the patient as opposed to attempting to be directly in contact with the target as a surgeon, interventional cardiologist or radiologist might do; 4) creative use of fiducial markers to allow targeting of structures (e.g. nerves) not otherwise directly visible with imaging technology. In many cases, advanced visualization and localization tools are utilized as well.

In accordance with some embodiments, a system for applying high intensity ultrasound energy to a nerve surrounding an artery of a patient includes a piezoelectric array comprising a plurality of ultrasound elements, a controller configured to individually control a phasing of each of the ultrasound elements, an algorithm to integrate inputs from the anatomy and patient and deliver outputs such as power and safety measure specific for proposed treatment, a platform on which the ultrasound elements are coupled, wherein the platform is configured to support at least a part of the patient, a programmable generator configured to generate an output power for at least one of the ultrasound elements, and a programmable processor configured to process a signal transmitted from one of the ultrasound elements and reflected back from tissue, and determine a tissue characteristic based on the reflected signal.

In any of the embodiments described herein, a first one of the ultrasound elements is configured to generate the signal, and a second one of the ultrasound elements is configured to sense the signal after it has been reflected from the tissue. In some embodiments, the first and second elements are the same, alternating between send and receive.

In any of the embodiments described herein, one of the ultrasound elements is configured to generate the signal, and to sense the signal after it has been reflected from the tissue.

In any of the embodiments described herein, the platform is compatible in a magnetic field.

In any of the embodiments described herein, the magnetic field is a permanent magnetic field with a field strength less than 1.0 Tesla.

In any of the embodiments described herein, one of the ultrasound elements is optimized to receive signals from a depth of greater than 8 cm.

In any of the embodiments described herein, the controller is configured to control a phasing of each of the ultrasound elements based at least in part on the determined tissue characteristic.

In any of the embodiments described herein, the ultrasound generating elements are programmable to focus therapeutic ultrasound energy at a target in the patient greater than 7 cm from a skin of the patient.

In any of the embodiments described herein, the system further includes a processor coupled to the piezoelectric array, wherein the processor is configured to determine a speed of blood, a direction of blood flow, or both.

In any of the embodiments described herein, the system further includes a mechanical motion actuator configured to mechanically move the piezoelectric array relative to a target within the patient.

In any of the embodiments described herein, the mechanical motion actuator comprises a ball in socket mechanism.

In any of the embodiments described herein, the mechanical motion actuator further comprises a locking mechanism.

In any of the embodiments described herein, at least one of the ultrasound elements is configured to receive an ultrasound signal from an intravascular piezoelectric element.

In any of the embodiments described herein, the system further includes a processor configured to determine an acoustic parameter based at least in part on the ultrasound signal.

In accordance with other embodiments, a system for ablating nerves surrounding a blood vessel includes a first ultrasound transducer configured to apply therapeutic energy across a blood vessel to heat nerves on both sides of the blood vessel, a second ultrasound transducer configured to receive reflected energy resulted an energy pulse from the first ultrasound transducer, and a processor configured to: receive first reflected energy data from the second ultrasound transducer at a first time point, receive second reflected energy data from the second ultrasound transducer at a second time point, compare the first reflected energy data with the second reflected energy data, and provide an output signal to a mover to control a position of the first ultrasound transducer.

In any of the embodiments described herein, the system further includes the mover, wherein the mover is inside of a table, and the table is configured to support a patient while allowing the first ultrasound transducer to couple to the patient.

In any of the embodiments described herein, the system further includes the mover, wherein the mover comprises a ball and socket mechanism.

In any of the embodiments described herein, the ball and socket mechanism is lockable.

In any of the embodiments described herein, the ball and socket mechanism comprises a vacuum lock mechanism.

In any of the embodiments described herein, the ball and socket mechanism is moveable along a plane.

In any of the embodiments described herein, the ball and socket mechanism is lockable along the plane with a vacuum mechanism.

In other embodiments, a method to treat a blood vessel and surrounding nerve includes identifying a region around the blood vessel to define a target zone, aiming a focal point of a focused ultrasound system towards the target zone, wherein the aiming is performed with respect to a three dimensional coordinate frame, detecting movement of the target zone relative to the focused ultrasound system, and determining a quality factor related to a relative degree of movement of the target zone relative to the focal point of the focused ultrasound system.

In any of the embodiments described herein, the quality factor is determined by a percentage of time the focal point is within the target zone.

In any of the embodiments described herein, the method further includes determining a dosing plan for the focused ultrasound system.

In any of the embodiments described herein, the method further includes modifying the dosing plan based at least in part on the quality factor.

In any of the embodiments described herein, the dosing plan defines a treatment cloud around the blood vessel.

In any of the embodiments described herein, the treatment cloud is substantially uniform with respect to the vessel.

In any of the embodiments described herein, the target zone movement is detected by detecting a Doppler flow signal.

In any of the embodiments described herein, the quality factor is about 90%.

In any of the embodiments described herein, the quality factor is about 50%.

In any of the embodiments described herein, the quality factor is anywhere from 50% to 90%.

In accordance with some embodiments, a system for treatment includes a focused ultrasound energy source for placement outside a patient, wherein the focused ultrasound energy source is configured to deliver ultrasound energy towards a blood vessel with a surrounding nerve that is a part of an autonomic nervous system inside the patient, and wherein the focused ultrasound energy source is configured to deliver the ultrasound energy from outside the patient to the nerve located inside the patient to treat the nerve.

In any of the embodiments described herein, the focused ultrasound energy source comprises a transducer, and a angle of the focused ultrasound source is anywhere between 30 degrees to 80 degrees with respect to a line traveling down a center of the transducer relative to a line connecting the transducer to the blood vessel.

In any of the embodiments described herein, the focused ultrasound energy source is configured to provide the ultrasound energy to achieve partial ablation of the nerve.

In any of the embodiments described herein, the focused ultrasound energy source is configured to deliver the ultrasound energy to the nerve from multiple directions outside the patient while the focused ultrasound energy source is stationary relative to the patient.

In any of the embodiments described herein, the system further includes an imaging processor for determining a position of the blood vessel.

In any of the embodiments described herein, the imaging processor comprises a CT device, a MRI device, a thermography device, an infrared imaging device, an optical coherence tomography device, a photoacoustic imaging device, a PET imaging device, a SPECT imaging device, or an ultrasound device.

In any of the embodiments described herein, the processor is configured to operate the focused ultrasound energy source to target the nerve that surrounds the blood vessel during the ultrasound energy delivery based on the determined position.

In any of the embodiments described herein, the processor is configured to determine the position using a Doppler triangulation technique.

In any of the embodiments described herein, the focused ultrasound energy source is configured to deliver the ultrasound energy having an energy level sufficient to decrease a sympathetic stimulus to the kidney, decrease an afferent signal from the kidney to an autonomic nervous system, or both.

In any of the embodiments described herein, the focused ultrasound energy source has an orientation so that the focused ultrasound energy source aims at a direction that aligns with the vessel that is next to the nerve.

In any of the embodiments described herein, the focused ultrasound energy source is configured to track a movement of the nerve.

In any of the embodiments described herein, the focused ultrasound energy source is configured to track the movement of the nerve by tracking a movement of the blood vessel next to the nerve.

In any of the embodiments described herein, the focused ultrasound energy source is configured to aim towards the nerve by aiming towards the blood vessel that is surrounded by the nerve.

In any of the embodiments described herein, the system further includes a device for placement inside the patient, and a processor for determining a position using the device, wherein the focused ultrasound energy source is configured to deliver the ultrasound energy based at least in part on the determined position.

In any of the embodiments described herein, the device is sized for insertion into the blood vessel that is surrounded by the nerve.

In any of the embodiments described herein, the focused ultrasound energy source is configured to deliver the ultrasound energy towards the blood vessel at an angle anywhere between −10 degrees and −48 degrees relative to a horizontal line connecting transverse processes of a spinal column, the angle directed from a lower torso to an upper torso of the patient.

In accordance with some embodiments, a system for treatment of a nerve surrounding a blood vessel traveling to a kidney includes an ultrasound energy source for placement outside a patient wherein the ultrasound energy source comprises an array of ultrasound transducers, and a programmable interface, configured to control the ultrasound energy source to deliver focused ultrasound to a region surrounding a blood vessel leading to the kidney through energizing one or more elements of the array in one or more phases, at an angle and offset to a central axis of the array to a tissue depth anywhere from 6 cm to 15 cm.

In any of the embodiments described herein, the focused ultrasound energy source comprises a transducer, and an angle of the focused ultrasound source is anywhere between 30 degrees to 80 degrees with respect to a line traveling down a center of the transducer relative to a line connecting from the transducer to the blood vessel.

In any of the embodiments described herein, the focused ultrasound energy source is configured to provide the ultrasound energy to achieve partial ablation of the nerve.

In any of the embodiments described herein, the system further includes an imaging processor for determining a position of the blood vessel.

In any of the embodiments described herein, the processor is configured to determine the position using a Doppler triangulation technique.

In any of the embodiments described herein, the focused ultrasound energy source is configured to track a movement of the nerve.

In any of the embodiments described herein, the focused ultrasound energy source is configured to track the movement of the nerve by tracking a movement of the blood vessel next to the nerve.

In any of the embodiments described herein, the focused ultrasound energy source is configured to aim towards the nerve by aiming towards the blood vessel that is surrounded by the nerve.

In any of the embodiments described herein, the device is sized for insertion into the blood vessel that is surrounded by the nerve.

In accordance with some embodiments, a system for treatment of an autonomic nervous system of a patient includes a focused ultrasound energy source for placement outside the patient, wherein the focused ultrasound energy source is configured to deliver ultrasound energy towards a blood vessel with a surrounding nerve that is a part of the autonomic nervous system inside the patient, and wherein the focused ultrasound energy source is configured to deliver the ultrasound energy based on a position of an indwelling vascular catheter.

In any of the embodiments described herein, the focused ultrasound energy source is configured to provide the ultrasound energy to achieve partial ablation of the nerve.

In any of the embodiments described herein, the system further includes an imaging processor for determining a position of the blood vessel.

In any of the embodiments described herein, the processor is configured to determine the position using a Doppler triangulation technique.

In any of the embodiments described herein, the focused ultrasound energy source is configured to track a movement of the nerve.

In any of the embodiments described herein, the focused ultrasound energy source is configured to track the movement of the nerve by tracking a movement of the blood vessel next to the nerve.

In any of the embodiments described herein, the focused ultrasound energy source is configured to aim towards the nerve by aiming towards the blood vessel that is surrounded by the nerve.

In accordance with some embodiments, a system for treatment includes a focused ultrasound energy source for placement outside a patient, wherein the focused ultrasound energy source is configured to deliver ultrasound energy towards a blood vessel with a surrounding nerve that is a part of an autonomic nervous system inside the patient, and wherein the focused ultrasound energy source is configured to deliver the ultrasound energy towards the blood vessel at an angle anywhere between −10 degrees and −48 degrees relative to a horizontal line connecting transverse processes of a spinal column, the angle directed from a lower torso to an upper torso of the patient.

In any of the embodiments described herein, the focused ultrasound energy source is configured to provide the ultrasound energy to achieve partial ablation of the nerve.

In any of the embodiments described herein, the system further includes an imaging processor for determining a position of the blood vessel.

In any of the embodiments described herein, the processor is configured to determine the position using a Doppler triangulation technique.

In any of the embodiments described herein, the focused ultrasound energy source is configured to track a movement of the nerve.

In any of the embodiments described herein, the focused ultrasound energy source is configured to track the movement of the nerve by tracking a movement of the blood vessel next to the nerve.

In any of the embodiments described herein, the focused ultrasound energy source is configured to aim towards the nerve by aiming towards the blood vessel that is surrounded by the nerve.

In any of the embodiments described herein, the device is sized for insertion into the blood vessel that is surrounded by the nerve.

In accordance with some embodiments, a method to apply a nerve inhibiting cloud surrounding a blood vessel includes creating a treatment plan, wherein the treatment plan prescribes application of the nerve inhibiting cloud towards at least a majority portion of a circumference of a blood vessel wall, and applying the nerve inhibiting cloud towards the majority portion of the circumference of the blood vessel wall for a time sufficient to inhibit a function of a nerve that surrounds the blood vessel wall.

In any of the embodiments described herein, the nerve inhibiting cloud comprises a cloud of light.

In any of the embodiments described herein, the nerve inhibiting cloud comprises a gaseous cloud.

In any of the embodiments described herein, the nerve inhibiting cloud comprises a heat cloud.

In any of the embodiments described herein, the nerve inhibiting cloud is applied using a transcutaneous energy source.

In any of the embodiments described herein, the nerve inhibiting cloud is applied using a transcutaneous energy source that is configured to deliver a focused ultrasound.

In any of the embodiments described herein, the nerve inhibiting cloud is applied using ionizing radiation.

In any of the embodiments described herein, the nerve inhibiting cloud is applied by delivering focused ultrasound, and the imaging device comprises an MRI device.

In any of the embodiments described herein, the method further includes obtaining an image of the blood vessel using an imaging device, wherein the treatment plan is created using the image.

In accordance with some embodiments, a system to deliver a nerve inhibiting cloud to a region surrounding a blood vessel includes a catheter comprising a plurality of electrodes configured to apply a cloud of heat, a processor storing a treatment plan that prescribes an application of the cloud of heat towards at least a majority of a circumference of a blood vessel wall surrounded by nerve, and an external detector configured for measuring temperature associated with the application of the cloud of heat.

In any of the embodiments described herein, the external detector comprises an ultrasound device.

In any of the embodiments described herein, the external detector comprises an MRI device.

In any of the embodiments described herein, the catheter is configured to be placed in a vein.

In any of the embodiments described herein, the catheter is configured to be placed into a visceral artery.

In accordance with some embodiments, a system to deliver a nerve inhibiting treatment to a nerve region surrounding a blood vessel includes a catheter comprising a component which is configured to be heated in response to an externally applied electromagnetic field, and a device configured for applying the electromagnetic field through a skin of a patient to heat the component of the catheter, wherein the heated component provides a heat cloud to the nerve region surrounding the blood vessel.

In any of the embodiments described herein, the catheter comprises an expandable member for pressing up against a wall of the blood vessel when the expandable member is expanded.

In any of the embodiments described herein, the device is further configured for measuring a temperature using the electromagnetic field.

In any of the embodiments described herein, the device comprises a magnetic resonance imaging device.

In any of the embodiments described herein, the device comprises an ultrasound detection device.

In accordance with some embodiments, a method to deliver focused ultrasound energy from a position outside a skin of a patient to a nerve surrounding a blood vessel includes placing the patient on a table in a substantially flat position, moving a transducer into a position inferior to ribs, superior to an iliac crest, and lateral to a spine of the patient, maintaining the transducer at the position relative to the patient, and delivering focused ultrasound energy through the skin of the patient without traversing bone, wherein the direction of the focused ultrasound is directed from a lower torso to an upper torso of the patient.

In any of the embodiments described herein, the method further includes detecting signals emanating from within the patient.

In any of the embodiments described herein, the method further includes detecting signals emanating from an intravascular device inside the patient.

In any of the embodiments described herein, the focused ultrasound energy is delivered to treat nerves inside the patient.

In any of the embodiments described herein, the nerves surrounds a vessel, and the focused ultrasound energy is delivered to the nerves by targeting the vessel.

In accordance with some embodiments, a system to deliver a nerve inhibiting treatment to a nerve region surrounding a blood vessel includes a catheter comprising a component which is configured to be heated in response to an externally applied electromagnetic field, and a magnetic resonance device configured for applying the electromagnetic field through a skin of a patient to heat the component of the catheter to a level that is sufficient to treat the nerve region surrounding the blood vessel, and a temperature detection system configured to limit a temperature of the nerve region surrounding the blood vessel.

In any of the embodiments described herein, the magnetic resonance device includes the temperature detection system.

In any of the embodiments described herein, the temperature detection system is inside the catheter.

In any of the embodiments described herein, the catheter is configured to be steered based at least in part on a signal provided by the magnetic resonance system.

In any of the embodiments described herein, the magnetic resonance system is configured to move the catheter towards a wall of the blood vessel.

In accordance with some embodiments, a system for treatment of a nerve surrounding a blood vessel traveling to a kidney includes an ultrasound energy source for placement outside a patient, wherein the ultrasound energy source comprises an array of ultrasound transducers, a programmable interface, configured to control the ultrasound energy source to deliver focused ultrasound to a region surrounding the blood vessel leading to the kidney through energizing one or more elements of the array in one or more phases, and a magnetic resonance imaging system comprising a permanent magnet, wherein the magnetic resonance imaging system is operatively coupled to the programmable interface.

In any of the embodiments described herein, the system further includes an intravascular catheter device for placement into the vessel.

In any of the embodiments described herein, the system further includes a radiofrequency coil for placement around an abdomen of the patient.

In any of the embodiments described herein, the system further includes a positioning device for delivering focused ultrasound energy to the region surrounding the blood vessel leading to the kidney.

In any of the embodiments described herein, the ultrasound energy source is configured to deliver the focused ultrasound at an angle and offset to a central axis of the array to a tissue depth anywhere from 6 cm to 15 cm.

In accordance with some embodiments, a system for treatment of a nerve surrounding a blood vessel traveling to a kidney includes an ultrasound energy source for placement outside a patient wherein the ultrasound energy source comprises an array of ultrasound transducers, a programmable interface, configured to control the ultrasound energy source to deliver focused ultrasound to a region surrounding the blood vessel leading to the kidney through energizing one or more elements of the array in one or more phases, and a processor configured to determine a quality factor based at least on an amount of time the focused ultrasound is within a pre-determined distance from a target.

In any of the embodiments described herein, the pre-determined distance is 500 microns.

In any of the embodiments described herein, the pre-determined distance is 2 mm.

In any of the embodiments described herein, the processor is further configured to operate the ultrasound energy source based at least in part on the quality factor.

In any of the embodiments described herein, the system further includes an intravascular catheter for placement into the vessel.

In any of the embodiments described herein, the intravascular catheter is configured to provide a signal related to movement of the region being treated, and the processor is configured to operate the ultrasound energy source based at least in part on the signal.

In any of the embodiments described herein, the system further includes a motion tracking system coupled to the processor.

In accordance with some embodiments, a device to apply focused ultrasound to a patient includes a transducer configured to deliver focused ultrasound to a blood vessel leading to a kidney, wherein the transducer comprises a plurality of individually phaseable elements, and a membrane for coupling the ultrasound to the patient, a first mechanical mover for positioning the transducer, wherein the first mechanical mover is configured to operate with the phaseable elements simultaneously to change a position of a focus of the transducer, and a second mechanical mover for maintaining a pressure between the membrane of the transducer and a skin of the patient.

In any of the embodiments described herein, the membrane contains fluid, and pressure and temperature of the fluid is maintained at a constant level.

In any of the embodiments described herein, the device further includes an imaging system operatively coupled to the first mechanical mover.

In any of the embodiments described herein, the imaging system is an MRI system.

In any of the embodiments described herein, the imaging system is an ultrasound system.

In any of the embodiments described herein, the imaging system is configured to detect an intravascular catheter.

In any of the embodiments described herein, the imaging system is configured to determine a three dimensional coordinate, and the transducer is configured to deliver the ultrasound based at least in part on the determined three dimensional coordinate.

A system for ablating nerves next to a blood vessel includes: a therapeutic ultrasound transducer configured to deliver energy to multiple target regions around the blood vessel, wherein the therapeutic ultrasound transducer comprises a series of piezoelectric ultrasound elements arranged on a flat or curved surface, each of the piezoelectric ultrasound elements having a partial ring configuration, and wherein a focal axis of the therapeutic ultrasound transducer resides at or near an edge of the therapeutic ultrasound transduce; a set of sensors coupled to the therapeutic ultrasound transducer, the sensors configured to determine a position of the blood vessel inside a patient, and a processor in communication with the sensors and the therapeutic ultrasound transducer, the processor being programmable with machine readable code, wherein the processor is configured to control the therapeutic ultrasound transducer to deliver the energy to the multiple target regions around the vessel in dependence on the position of the blood vessel determined using the sensors; wherein the sensors are configured to provide multiple input to the processor at multiple respective times, the multiple input indicative of the position of the blood vessel at the multiple respective times.

Optionally, the processor is configured to control the therapeutic ultrasound transducer to deliver energy to the multiple target regions to create a prescribed pattern of lesions around the blood vessel.

Optionally, one of the target regions has a probability of including one or more nerves.

Optionally, the therapeutic ultrasound transducer is configured to delivery energy sequentially to the target regions around the blood vessel from outside the patient.

Optionally, the sensors are parts of an imaging device.

Optionally, the sensors are configured to detect one or more signals emanating from within the blood vessel.

Optionally, the processor is configured to control the therapeutic ultrasound transducer in dependence on the input from the sensors.

Optionally, the processor is configured to control the therapeutic ultrasound transducer by controlling a position of the therapeutic ultrasound transducer, and/or a phasing of transducer elements of the therapeutic ultrasound transducer.

Optionally, the processor is configured to control the therapeutic ultrasound transducer so that the therapeutic ultrasound transducer deliver the energy to the multiple target regions that are offset from a reference position inside the blood vessel.

Optionally, the position of the blood vessel has a first value at one of the times, and a second value at another one of the times, the first value and the second value being different.

Optionally, the multiple target regions comprise at least a first target region and a second target region.

Optionally, the sensors are configured to provide at least one of the input to the processor before the therapeutic ultrasound transducer delivers energy to the first target region, and to provide at least another one of the input to the processor before the therapeutic ultrasound transducer delivers energy to the second target region.

Optionally, the sensors are configured to provide the at least another one of the input to the processor after the therapeutic ultrasound transducer delivers energy to the first target region.

Optionally, the processor is configured to control the therapeutic ultrasound transducer to deliver the energy to at least one of the target regions so that the delivered energy covers a volume of at least 1 cm³.

A method for determining an effect of a treatment on an autonomic nervous system includes: delivering energy to a baroreceptor complex; determining an effect of the delivery of the energy to the baroreceptor complex; and determining whether to continue or discontinue therapy to the autonomic nervous system based at least in part on the effect of the delivery of the energy to the baraoreceptor complex.

Optionally, the energy comprises ultrasound energy, radiofrequency energy, or light energy.

Optionally, the effect comprises a change in blood pressure.

Optionally, the therapy to the autonomic nervous system is continued if the delivery of the energy results in a lowering of blood pressure by a prescribed amount.

Optionally, energy dose is increased in the continued therapy.

Optionally, the therapy to the autonomic nervous system is discontinued if the delivery of the energy does not result in a lowering of blood pressure by a prescribed amount.

Optionally, the energy is delivered to a carotid sinus.

Optionally, the energy is delivered to a carotid body.

Optionally, the energy is delivered by applying pressure towards the baroreceptor complex using a hand or a device.

A method for determining a change in an autonomic nervous system in a patient includes: delivering electromagnetic energy from a position external to the patient to a carotid sinus or a carotid body; detecting a change in the autonomic nervous system caused by the delivered energy; initiating, stopping, or altering a treatment of the patient based on the detected change.

Optionally, the treatment is initiated if the detected change is above a prescribed threshold.

Optionally, the treatment is stopped if the detected change is below a prescribed threshold.

Optionally, the treatment is altered to increase an energy dose if a result of the detected change indicates that a desired treatment result has not been obtained.

A method for altering a balance of a autonomic nervous system includes: delivering energy from a position external to a patient, through a skin of the patient, to one or more nerves associated with a carotid body or a carotid sinus of the patient.

Optionally, the energy comprises electromagnetic energy.

Optionally, the energy comprises ultrasound energy.

Optionally, the energy comprises radiofrequency energy.

Other and further aspects and features will be evident from reading the following detailed description of the embodiments.

DESCRIPTION OF FIGURES

FIGS. 1A-1B depict the focusing of energy sources on nerves of the autonomic nervous system.

FIG. 1C depicts an imaging system to help direct the energy sources.

FIG. 1D depicts a system integration schematic.

FIG. 1E depicts a box diagram of an integrated system schematic.

FIG. 2 depicts targeting and/or therapeutic ultrasound delivered through the stomach to the autonomic nervous system posterior to the stomach.

FIG. 3A depicts focusing of energy waves on the renal nerves.

FIG. 3B depicts a coordinate reference frame for the treatment.

FIG. 3C depicts targeting catheters or energy delivery catheters placed in any of the renal vessels.

FIG. 3D depicts an image detection system of a blood vessel with a temporary fiducial placed inside the blood vessel, wherein the fiducial provides positional information with respect to a reference frame.

FIG. 3E depicts a therapy paradigm for the treatment and assessment of hypertension.

FIG. 4A depicts the application of energy to the autonomic nervous system surrounding the carotid arteries.

FIG. 4B depicts the application of energy to the vessels of the renal hilum.

FIGS. 5A-5B depict the application of focused energy to the autonomic nervous system of the eye.

FIG. 5C depicts the application of energy to other autonomic nervous system structures.

FIG. 6 depicts the application of constricting lesions to the kidney deep inside the calyces of the kidney.

FIG. 7A depicts a patient in an imaging system receiving treatment with focused energy waves.

FIG. 7B depicts visualization of a kidney being treated.

FIG. 7C depicts a close up view of the renal nerve region of the kidney being treated.

FIG. 7D depicts an algorithmic method to treat the autonomic nervous system using MRI and energy transducers.

FIG. 7E depicts a geometric model obtained from cross-sectional images of the area of the aorta and kidneys along with angles of approach to the blood vessels and the kidney.

FIG. 7F depicts a close up image of the region of treatment.

FIG. 7G depicts the results of measurements from a series of cross sectional image reconstructions.

FIG. 7H depicts the results of measurements from a series of cross-sectional images from a patient in a more optimized position.

FIG. 7I depicts an algorithmic methodology to apply treatment to the hilum of the kidney and apply energy to the renal blood vessels.

FIG. 7J depicts a clinical algorithm to apply energy to the blood vessel leading to the kidney.

FIG. 7K depicts a device to diagnose proper directionality to apply energy to the region of the kidney.

FIG. 7L depicts a methodology to ablate a nerve around an artery by applying a cloud of heat or neurolytic substance.

FIG. 7M depicts a clinical algorithm to apply energy along a renal blood vessel.

FIG. 7N depicts a cloud of heat to affect the nerves leading to the kidney.

FIG. 7O depicts a close up of a heat cloud as well as nerves leading to the kidney.

FIGS. 7P-7Q depict modeling and simulation that correspond with a dosing and motion control algorithm in accordance with some embodiments.

FIGS. 7R-7U depict alternative techniques to direct a catheter inside a patient using time of flight sensors placed outside the patient.

FIG. 7V depicts a distal portion of a catheter.

FIG. 8A depicts a percutaneous approach to treating the autonomic nervous system surrounding the kidneys.

FIG. 8B depicts an intravascular approach to treating or targeting the autonomic nervous system.

FIG. 8C depicts a percutaneous approach to the renal hila using a CT scan and a probe to reach the renal blood vessels.

FIG. 8D depicts an intravascular detection technique to characterize the interpath between the blood vessel and the skin.

FIGS. 8E-8F depict cross sectional images with focused energy traveling from a posterior direction.

FIGS. 8G-I depict results of a targeting experiment to localize an intravascular targeting beacon.

FIGS. 9A-9C depicts the application of energy from inside the aorta to regions outside the aorta to treat the autonomic nervous system.

FIG. 10 depicts steps to treat a disease using HIFU while monitoring progress of the treatment as well as motion.

FIG. 11
a depicts step to turn off therapy upon specific triggers.

FIG. 11
b depicts blood vessel movements which lead to specific shutoff triggers.

FIG. 12 depicts treatment of the renal nerve region using a laparoscopic approach.

FIG. 13 depicts a methodology for destroying a region of tissue using imaging markers to monitor treatment progress.

FIG. 14 depicts the partial treatment of portions of a nerve bundle using converging imaging and therapy wave.

FIGS. 15
a-c depict various methodologies and embodiments to deliver energy to the hilum region of the kidney.

FIG. 16A depicts the types of lesions which are created around the renal arteries to affect a response.

FIG. 16B depicts a simulation of ultrasound around a blood vessel I support of FIG. 16A.

FIG. 16C depicts data from ultrasound energy applied to the renal blood vessels and the resultant change in norepinephrine levels.

FIGS. 16D-16H depict a simulation of multiple treatment spots along a blood vessel.

FIGS. 16I-16K depict various treatment plans of focused energy around a blood vessel.

FIGS. 16L-16M depict data indicating that focused energy applied from the outside can affect sympathetic nerve supply to organs.

FIG. 16N depicts results of a time course of an experiment in which sympathetic nerves were inhibited.

FIG. 17A depicts the application of multiple transducers to treat regions of the autonomic nervous system at the renal hilum.

FIGS. 17B-17C depict methods for using imaging to direct treatment of a specific region surrounding an artery as well as display the predicted lesion morphology.

FIG. 17D depicts a method for localizing HIFU transducers relative to Doppler ultrasound signals.

FIG. 17E depicts an arrangement of transducers relative to a target.

FIG. 17F depicts ablation zones in a multi-focal region in cross-section.

FIG. 18 depicts the application of energy internally within the kidney to affect specific functional changes at the regional level within the kidney.

FIG. 19A depicts the direction of energy wave propagation to treat regions of the autonomic nervous system around the region of the kidney hilum.

FIG. 19B depicts a schematic of a B mode ultrasound from a direction determined through experimentation to provide access to the renal hilum with HIFU.

FIGS. 19C-19D depict a setup for the treatment of the renal blood vessels along with actual treatment of the renal blood vessels.

FIG. 19E is a schematic algorithm of the treatment plan for treatment shown in FIG. 19C-D.

FIG. 20 depicts the application of ultrasound waves through the wall of the aorta to apply a therapy to the autonomic nervous system.

FIG. 21 depicts treatment of nerves surrounding blood vessels traveling to the liver and other abdominal viscera.

FIG. 22 depicts an embodiment for treating varicose veins with the described technology.

FIG. 23 depicts treatment of atrial fibrillation with the described technology.

FIG. 24 depicts an algorithm to assess the effect of the neural modulation procedure on the autonomic nervous system. After a procedure is performed on the renal nerves, assessment of the autonomic response is performed by, for example, simulating the autonomic nervous system in one or more places.

FIG. 25 depicts an optimized position of a device to apply therapy to internal nerves.

FIG. 26A depicts positioning of a patient to obtain parameters for system design.

FIG. 26B depicts a device design based on the information learned from feasibility studies.

FIG. 27A depicts a clinical paradigm for treating the renal nerves of the autonomic nervous system based on feasibility studies.

FIGS. 27B-C depict various blood pressure techniques used to measure blood pressure during treatments.

FIGS. 28A-28C depict a treatment positioning system for a patient incorporating a focused ultrasound system.

FIGS. 28D-28I illustrate system configurations for a system to treat nerves inside a patient using focused energy.

FIG. 28J is a depiction of an underlining for the patient with partial or fully inflated elements.

FIG. 28K is a configuration of a system built into a table for a patient.

FIG. 28L depicts a multi-dimensional mechanism to move an ultrasound transducer in accordance with some embodiments.

FIG. 28M is patient interface configuration in which the patient is supine and an ultrasound transducer is placed underneath the patient.

FIG. 28N is close up of the table on which a patient lays supine.

FIGS. 29A-D depict results of studies applying focused energy to nerves surrounding arteries and of ultrasound studies to visualize the blood vessels around which the nerves travel.

FIG. 29E depicts the results of design processes in which the angle, length, and surface area from CT scans is quantified.

FIGS. 30A-30I depict results of simulations to apply focused ultrasound to the region of a renal artery with a prototype device design based on simulations.

FIG. 30J depicts an annular array customized to treat the anatomy shown for the kidney and renal blood vessels above.

FIG. 30K highlights the annular array and depicts the imaging component at the apex.

FIGS. 30L-N depict various cutouts for ultrasound imaging probes.

FIGS. 30O-P depict projection from the proposed transducer designs.

FIG. 30Q is a depiction of a focal zone created by the therapeutic transducer(s) to focus a single region.

FIGS. 30R-30S depict a multi-element array in a pizza slice shape yet with many square elements.

FIGS. 30T-30U depict simulations of the annular array specific for the anatomy to be treated around a kidney of a patient.

FIG. 30V depicts a housing for the custom array.

FIG. 30W depicts focusing of energy from the custom array along a blood vessel.

FIG. 31A depicts an off center focus from an alternative arrangement of the annular array transducer.

FIG. 31B depicts focusing of energy from an alternative embodiment of the customized transducer array in the clinical embodiment in which a catheter is placed within the patient.

FIG. 31C is a depiction of a movement mechanism within a patient table.

FIG. 31D is an overall block diagram of the system subsystems.

FIG. 31E depicts a transducer set up underneath a patient.

FIG. 31F depicts a close up of the transducer delivering energy to the autonomic nerves surrounding the renal artery.

FIG. 31G depicts a transducer customized to deliver focused ultrasound to the nerves surrounding the renal artery.

FIG. 31H depicts an intravascular catheter which sends a signal to the customized ultrasound transducer.

FIG. 31I depicts an analysis of the phases computed from each element on the transducer in FIG. 31H receiving a signal from the intravascular catheter.

FIG. 31J depicts a simulation of the transducer in FIG. 31G delivering power to the renal blood vessel region and incorporating blood flow of the renal blood vessel.

FIG. 31K depicts quantitative results of a simulation based on a CT scan.

FIG. 31L depicts results of a human sized animal model revealing a dose response with respect to the transducer in FIG. 31G.

FIG. 31M depicts the result of pathology which validates the modeling showing damage to nerves without damage to the artery.

FIG. 31N depict the results of correcting phase and the resultant acoustic velocity of the waves traveling through to the blood vessel.

FIG. 31O depicts a pattern of focused ultrasound delivery around a blood vessel. The numbered circles are the points where focused ultrasound is applied around the blood vessel.

FIG. 31P depicts results in human patients revealing a drop in blood pressure as a result of treatment of nerves surrounding the renal artery.

FIG. 31Q is a depiction of the pattern around the blood vessel revealing the lengthwise section of the blood vessel.

DETAILED DESCRIPTION

Hypertension is a disease of extreme national and international importance. There are 80 million patients in the US alone who have hypertension and over 200 million in developed countries worldwide. In the United States, there are 60 million patients who have uncontrolled hypertension, meaning that they are either non-compliant or cannot take the medications because of the side effect profile. Up to 10 million people might have completely resistant hypertension in which they do not reach target levels no matter what the medication regimen. The morbidities associated with uncontrolled hypertension are profound, including stroke, heart attack, kidney failure, peripheral arterial disease, etc. A convenient and straightforward minimally invasive procedure to treat hypertension would be a very welcome advance in the treatment of this disease.

Congestive Heart Failure (“CHF”) is a condition which occurs when the heart becomes damaged and blood flow is reduced to the organs of the body. If blood flow decreases sufficiently, kidney function becomes altered, which results in fluid retention, abnormal hormone secretions and increased constriction of blood vessels. These results increase the workload of the heart and further decrease the capacity of the heart to pump blood through the kidneys and circulatory system.

It is believed that progressively decreasing perfusion of the kidneys is a principal non-cardiac cause perpetuating the downward spiral of CHF. For example, as the heart struggles to pump blood, the cardiac output is maintained or decreased and the kidneys conserve fluid and electrolytes to maintain the stroke volume of the heart. The resulting increase in pressure further overloads the cardiac muscle such that the cardiac muscle has to work harder to pump against a higher pressure. The already damaged cardiac muscle is then further stressed and damaged by the increased pressure. Moreover, the fluid overload and associated clinical symptoms resulting from these physiologic changes result in additional hospital admissions, poor quality of life, and additional costs to the health care system. In addition to exacerbating heart failure, kidney failure can lead to a downward spiral and further worsening kidney function. For example, in the forward flow heart failure described above, (systolic heart failure) the kidney becomes ischemic. In backward heart failure (diastolic heart failure), the kidneys become congested vis-à-vis renal vein hypertension. Therefore, the kidney can contribute to its own worsening failure.

The functions of the kidneys can be summarized under three broad categories: filtering blood and excreting waste products generated by the body's metabolism; regulating salt, water, electrolyte and acid-base balance; and secreting hormones to maintain vital organ blood flow. Without properly functioning kidneys, a patient will suffer water retention, reduced urine flow and an accumulation of waste toxins in the blood and body. These conditions result from reduced renal function or renal failure (kidney failure) and are believed to increase the workload of the heart. In a CHF patient, renal failure will cause the heart to further deteriorate as fluids are retained and blood toxins accumulate due to the poorly functioning kidneys. The resulting hypertension also has dramatic influence on the progression of cerebrovascular disease and stroke.

The autonomic nervous system is a network of nerves which affect almost every organ and physiologic system to a variable degree. Generally, the system is composed of sympathetic and parasympathetic nerves. For example, the sympathetic nerves to the kidney traverse the sympathetic chain along the spine and synapse within the ganglia of the chain or within the celiac ganglia, then proceeding to innervate the kidney via post-ganglionic fibers inside the “renal nerves.” Within the renal nerves, which travel along the renal hila (artery and to some extent the vein), are the post-ganglionic sympathetic nerves and the afferent nerves from the kidney. The afferent nerves from the kidney travel within the dorsal root (if they are pain fibers) and into the anterior root if they are sensory fibers, then into the spinal cord and ultimately to specialized regions of the brain. The afferent nerves, baroreceptors and chemoreceptors, deliver information from the kidneys back to the sympathetic nervous system via the brain; their ablation or inhibition is at least partially responsible for the improvement seen in blood pressure after renal nerve ablation, or denervation, or partial disruption. It has also been suggested and partially proven experimentally that the baroreceptor response at the level of the carotid sinus is mediated by the renal artery afferent nerves such that loss of the renal artery afferent nerve response blunts the response of the carotid baroreceptors to changes in arterial blood pressure (American J. Physiology and Renal Physiology 279:F491-F501, 2000).

It has been established in animal models that the heart failure condition results in abnormally high sympathetic activation of the kidneys. An increase in renal sympathetic nerve activity leads to decreased removal of water and sodium from the body, as well as increased renin secretion which stimulates aldosterone secretion from the adrenal gland. Increased renin secretion can lead to an increase in angiotensin II levels which leads to vasoconstriction of blood vessels supplying the kidneys as well as systemic vasoconstriction, all of which lead to a decrease in renal blood flow and hypertension. Reduction in sympathetic renal nerve activity, e.g., via de-innervation, may reverse these processes and in fact has been shown to in the clinic. Similarly, in obese patients, the sympathetic drive is intrinsically very high and is felt to be one of the causes of hypertension in obese patients.

Recent clinical work has shown that de-innervation of the renal sympathetic chain and other nerves which enter the kidney through the hilum can lead to profound systemic effects in patients (rats, dogs, pig, sheep, humans) with hypertension, heart failure, and other organ system diseases. Such treatment can lead to long term reduction in the need for blood pressure medications and improvements in blood pressure (O'Brien Lancet 2009 373; 9681). The devices used in this trial were highly localized radiofrequency (RF) ablation to ablate the renal artery adventitia with the presumption that the nerves surrounding the renal artery are being inhibited in the heating zone as well. The procedure is performed in essentially a blind fashion in that the exact location of the nerve plexus is not known prior to, during, or after the procedure. In addition, the wall of the renal artery is invariably damaged by the RF probe and patients whose vessels have a great deal of atherosclerosis cannot be treated safely. In addition, depending on the distance of the nerves from the vessel wall, the energy may not consistently lead to ablation or interruption. Finally, the use of internal catheters may not allow for treatment inside the kidney or inside the aorta if more selective. In many cases, it is required to create a spiral along the length and inside the blood vessel to avoid circumferential damage to the vessel.

Cross-sectional imaging can be utilized to visualize the internal anatomy of patients via radiation (CT) or magnetic fields (MRI). Ultrasound can also be utilized to obtain cross-sections of specific regions but only at high frequencies; therefore, ultrasound is typically limited to imaging superficial body regions. CT and MRI are often more amenable to cross sectional imaging because the radiation penetrates well into tissues. In addition, the scale of the body regions is maintained such that the anatomy within the coordinate references remains intact relative to one another; that is, distances between structures can be measured.

With ultrasound, scaling can be more difficult because of unequal penetration as the waves propagate deeper through the tissue. CT scans and MRIs and even ultrasound devices can be utilized to create three dimensional representations and reconstructed cross-sectional images of patients; anatomy can be placed in a coordinate reference frame using a three dimensional representation. Once in the reference frame, energy devices (transducers) can be placed in position and energy emitting devices directed such that specific regions of the body are targeted. Once knowledge of the transducer position is known relative to the position of the target in the patient body, energy can be delivered to the target.

Ultrasound is a cyclically generated sound pressure wave with a frequency greater than the upper limit of human hearing . . . 20 kilohertz (kHz). In medicine, ultrasound is widely utilized because of its ability to penetrate tissues. Reflection of the sound waves reveals a signature of the underlying tissues and as such, ultrasound can be used extensively for diagnostics and potentially therapeutics as well in the medical field. As a therapy, ultrasound has the ability to both penetrate tissues and can be focused to create ablation zones. Because of its simultaneous ability to image, ultrasound can be utilized for precise targeting of lesions inside the body. Ultrasound intensity is measured by the power per cm²(for example, W/cm²at the therapeutic target region). Generally, high intensity refers to intensities over 0.1-5 kW/cm². Low intensity ultrasound encompasses the range up to 0.01-0.10 kW/cm²from about 1 or 10 Watts per cm².

Ultrasound can be utilized for its forward propagating waves and resulting reflected waves or where energy deposition in the tissue and either heating or slight disruption of the tissues is desired. For example, rather than relying on reflections for imaging, lower frequency ultrasonic beams (e.g. <1 MHz) can be focused at a depth within tissue, creating a heating zone or a defined region of cavitation in which micro-bubbles are created, cell membranes are opened to admit bioactive molecules, or damage is otherwise created in the tissue. These features of ultrasound generally utilize frequencies in the 0.25 Megahertz (MHz) to 10 MHz range depending on the depth required for effect. Focusing is, or may be, required so that the surface of the tissue is not excessively injured or heated by single beams. In other words, many single beams can be propagated through the tissue at different angles to decrease the energy deposition along any single path yet allow the beams to converge at a focal spot deep within the tissue. In addition, reflected beams from multiple angles may be utilized in order to create a three dimensional representation of the region to be treated in a coordinate space.

It is important when planning an ultrasound therapy that sharp, discontinuous interfaces be avoided. For example, bowel, lung, bone which contain air and/or bone interfaces constitute sharp boundaries with soft tissues. These interfaces make the planning and therapy more difficult. If however, the interfaces can be avoided, then treatment can be greatly simplified versus what has to be done for the brain (e.g. MR-guided HIFU) where complex modeling is required to overcome the very high attenuation of the cranium. Data provided below reveals a discovery through extensive experimentation as to how to achieve this treatment simplicity for treatment of specific structures such as nerves surrounding blood vessels.

Time of flight measurements with ultrasound can be used to range find, or find distances between objects in tissues. Such measurements can be utilized to place objects such as vessels into three dimensional coordinate reference frames so that energy can be utilized to target the tissues. SONAR is the acronym for sound navigation and ranging and is a method of acoustic localization. Sound waves are transmitted through a medium and the time for the sound to reflect back to the transmitter is indicative of the position of the object of interest. Doppler signals are generated by a moving object. The change in the forward and reflected wave results in a velocity for the object.

The concept of speckle tracking is one in which the reflections of specific tissues is defined and tracked over time (IEEE Transactions on Ultrasonics, Ferroelectrics, AND Frequency Control, Vol. 57, no. 4, April 2010). With defined points in space, a three dimensional coordinate reference can be created through which energy can be applied to specific and well-defined regions. To track a speckle, an ultrasound image is obtained from a tissue. Light and dark spots are defined in the image, these light and dark spots representing inhomgeneities in the tissues. The inhomegeneities are relatively constant, being essentially properties of the tissue. With relatively constant markers in the tissue, tracking can be accomplished using real time imaging of the markers. With more than one plane of ultrasound, the markers can be related in three dimensions relative to the ultrasound transducer and a therapeutic energy delivered to a defined position within the three dimensional field.

At the time one or more of these imaging modalities is utilized to determine the position of the target in three dimensions, then a therapy can be both planned and applied to a specific region within the three dimensional volume. The speckles being tracked do not have to correspond to the region being treated. For example, a region in an image might contain large speckles which are easy track although another region of the image is the place where therapy is being applied.

Lithotripsy was introduced in the early part of the 1980's. Lithotripsy utilizes shockwaves to treat stones in the kidney. The Dornier lithotripsy system was the first system produced for this purpose. The lithotripsy system sends ultrasonic waves through the patient's body to the kidney to selectively heat and vibrate the kidney stones; that is, selectively over the adjacent tissue. At the present time, lithotripsy systems do not utilize direct targeting and imaging of the kidney stone region. A tremendous advance in the technology would be to image the stone region and target the specific region in which the stone resides so as to minimize damage to surrounding structures such as the kidney. In the case of a kidney stone, the kidney is in fact the speckle, allowing for three dimensional targeting and tracking off its image with subsequent application of ultrasound waves to break up the stone. In the embodiments which follow below, many of the techniques and imaging results described can be applied to clinical lithotripsy. For example, imaging of the stone region and tracking of the stone region can lead to an improved targeting system for breaking up kidney stones. Rather than wasting energy on regions which don't contain stones and destroying healthy kidney, energy can be concentrated on the portions of the kidney which contain the stones.

Histotripsy is a term given to a technique in which tissue is essentially vaporized using cavitation rather than heating (transcutaneous non-thermal mechanical tissue fractionation). These mini explosions do not require high temperature and can occur in less than a second. The generated pressure wave is in the range of megapascals (MPa) and even up to or exceeding 100 MPa. To treat small regions of tissue very quickly, this technique can be very effective. The border of the viable and non-viable tissue is typically very sharp and the mechanism of action has been shown to be cellular disruption.

In one embodiment, ultrasound is focused on the region of the renal arteries and/or veins from outside the patient; the ultrasound is delivered from multiple angles to the target, thereby overcoming many of the deficiencies in previous methods and devices put forward to ablate renal sympathetic nerves which surround the renal arteries.

Specifically, one embodiment allows for precise visualization of the ablation zone so that the operator can be confident that the correct region is ablated and that the incorrect region is not ablated. Because some embodiments do not require a puncture in the skin, they are considerably less invasive, which is more palatable and safer from the patient standpoint. Moreover, unusual anatomies and atherosclerotic vessels can be treated using external energy triangulated on the renal arteries to affect the sympathetic and afferent nerves to and from the kidney respectively.

With reference to FIG. 1A, the human renal anatomy includes the kidneys 100 which are supplied with oxygenated blood by the renal arteries 200 and are connected to the heart via the abdominal aorta 300. Deoxygenated blood flows from the kidneys to the heart via the renal veins (not shown) and thence the inferior vena cava (not shown). The renal anatomy includes the cortex, the medulla, and the hilum. Blood is delivered to the cortex where it filters through the glomeruli and is then delivered to the medulla where it is further filtered through a series of reabsorption and filtration steps in the loops of henle and individual nephrons; the ultrafiltrate then percolates to the urethral collecting system and is delivered to the ureters and bladder for ultimate excretion.

The hila is the region where the major vessels (renal artery and renal vein) and nerves 150 (efferent sympathetic, afferent sensory, and parasympathetic nerves) travel to and from the kidneys. The renal nerves 150 contain post-ganglionic efferent nerves which supply sympathetic innervation to the kidneys. Afferent sensory nerves travel from the kidney to the central nervous system and are postganglionic afferent nerves with nerve bodies in the central nervous system. These nerves deliver sensory information to the central nervous system and are thought to regulate much of the sympathetic outflow from the central nervous system to all organs including the skin, heart, kidneys, brain, etc.

In one method, energy is delivered from outside a patient, through the skin, and to the renal afferent and/or renal efferent nerves. Microwave, magnetic, electromagnetic energy, light, vibratory (e.g. acoustic), ionizing radiation might be utilized in some or many of the embodiments.

Energy transducers 500 (FIG. 1A) deliver energy transcutaneously to the region of the sympathetic ganglia 520 or the post-ganglionic renal nerves 150 or the nerves leading to the adrenal gland 400. The energy is generated from outside the patient, from multiple directions, and through the skin to the region of the renal nerves 624 which surround the renal artery 620 or the sympathetic ganglion 622 which house the nerves. The energy can be focused or non-focused but in one preferred embodiment, the energy is focused with high intensity focused ultrasound (HIFU) or low intensity focused ultrasound.

Focusing with low intensity focused ultrasound (LIFU) may also occur intentionally as a component of the HIFU (penumbra regions) or unintentionally. The mechanism of nerve inhibition is variable depending on the “low” or “high” of focused ultrasound. Low energy might include energy levels of 25 W/cm²-200 W/cm². Higher intensity includes energy levels from 200 W/cm²to 1 MW/cm². Focusing occurs by delivering energy from at least two different angles through the skin to meet at a focal point where the highest energy intensity and density occurs. At this spot, a therapy is delivered and the therapy can be sub-threshold nerve interruption (partial ablation), ablation (complete interruption) of the nerves, controlled interruption of the nerve conduction apparatus, partial ablation, or targeted drug delivery. The region can be heated to a temperature of less than 60 degrees Celsius for non-ablative therapy or can be heated greater than 60 degrees Celsius for heat based destruction (ablation). To ablate the nerves, even temperatures in the 40 degree Celsius range can be used and if generated for a time period greater than several minutes, will result in ablation. For temperatures at about 50 degrees Celsius, the time might be under one minute. Heating aside, a vibratory effect for a much shorter period of time at temperatures below 60 degrees Celsius can result in partial or complete paralysis or destruction of the nerves. If the temperature is increased beyond 50-60 degrees Celsius, the time required for heating is decreased considerably to affect the nerve via the sole mechanism of heating. In some embodiments, an imaging modality is included as well in the system. The imaging modality can be ultrasound based, MRI based, fluoroscopy, or CT (X-Ray) based. The imaging modality can be utilized to target the region of ablation and determined the distances to the target.

The delivered energy can be ionizing or non-ionizing energy in some embodiments. Forms of non-ionizing energy can include electromagnetic energy such as a magnetic field, light, an electric field, radiofrequency energy, and light based energy. Forms of ionizing energy include x-ray, proton beam, gamma rays, electron beams, and alpha rays. In some embodiments, the energy modalities are combined. For example, heat ablation of the nerves is performed and then ionizing radiation is delivered to the region to prevent re-growth of the nerves.

Alternatively, ionizing radiation is applied first as an ablation modality and then heat applied afterward in the case of re-growth of the tissue as re-radiation may not be possible (complement or multimodality energy utilization). Ionizing radiation may prevent or inhibit the re-growth of the nervous tissue around the vessel if there is indeed re-growth of the nervous tissue. Therefore, another method of treating the nerves is to first heat the nerves and then apply ionizing radiation to prevent re-growth.

Other techniques such as photodynamic therapy including a photosensitizer and light source to activate the photosensitizer can be utilized as a manner to combine modalities. Most of these photosensitizing agents are also sensitive to ultrasound energy yielding the same photoreactive species as if it were activated by light. A photoreactive or photosensitive agent can be introduced into the target area prior to the apparatus being introduced into the blood vessel; for example, through an intravenous injection, a subcutaneous injection, etc. However, it will be understood that if desired, the apparatus can optionally include a lumen for delivering a photoreactive agent into the target area. The resulting embodiments are likely to be particularly beneficial where uptake of the photoreactive agent into the target tissues is relatively rapid, so that the apparatus does not need to remain in the blood vessel for an extended period of time while the photoreactive agent is distributed into and absorbed by the target tissue.

Light source arrays can include light sources that provide more than one wavelength or waveband of light. Linear light source arrays are particularly useful to treat elongate portions of tissue. Light source arrays can also include reflective elements to enhance the transmission of light in a preferred direction. For example, devices can beneficially include expandable members such as inflatable balloons to occlude blood flow (which can interfere with the transmission of light from the light source to the intended target tissue) and to enable the apparatus to be centered in a blood vessel. Another preferred embodiment contemplates a transcutaneous PDT method where the photosensitizing agent delivery system comprises a liposome delivery system consisting essentially of the photosensitizing agent. Light sources may be directed at a focus from within a blood vessel to a position outside a blood vessel. Infrared, Red, Blue, Green, and ultraviolet light may be used from within a blood vessel to affect nervous tissue outside the blood vessel. Light emitting diodes may be introduced via catheter to the vein, the artery, the aorta, etc. After introduction of the photoreactive agent (e.g. via intravenous, subcutaneous, transarterial, transvenous injection), the light is applied through the blood vessel wall in a cloud of energy which activates the photoreactive agents.

Yet another embodiment is drawn to a method for transcutaneous ultrasonic therapy of a target lesion in a mammalian subject utilizing a sensitizer agent. In this embodiment, the biochemical compound is activated by ultrasound through the following method:

1) administering to the subject a therapeutically effective amount of an ultrasonic sensitizing agent or a ultrasonic sensitizing agent delivery system or a prodrug, where the ultrasonic sensitizing agent or ultrasonic sensitizing agent delivery system or prodrug selectively binds to the thick or thin neointimas, nerve cells, nerve sheaths, nerve nuclei, arterial plaques, vascular smooth muscle cells and/or the abnormal extracellular matrix of the site to be treated. Nerve components can also be targeted, for example, the nerve sheath, myelin, S-100 protein. This step is followed by irradiating at least a portion of the subject with ultrasonic energy at a frequency that activates the ultrasonic sensitizing agent or if a prodrug, by a prodrug product thereof, where the ultrasonic energy is provided by an ultrasonic energy emitting source. This embodiment further provides, optionally, that the ultrasonic therapy drug is cleared from non-target tissues of the subject prior to irradiation.

A preferred embodiment contemplates a method for transcutaneous ultrasonic therapy of a target tissue, where the target tissue is close to a blood vessel and the blood vessel is used as a fiducial to determine the position for energy deposition. Other preferred embodiments contemplate that the ultrasonic energy emitting source is external to the patient's intact skin layer or is inserted underneath the patient's intact skin layer, but is external to the blood vessel to be treated. An additional preferred embodiment provides that the ultrasonic sensitizing agent is conjugated to a ligand and more preferably, where the ligand is selected from the group consisting of: a target lesion specific antibody; a target lesion specific peptide and a target lesion specific polymer. Other preferred embodiments contemplate that the ultrasonic sensitizing agent is selected from the group consisting of: indocyanine green (ICG); methylene blue; toluidine blue; aminolevulinic acid (ALA); chlorin compounds; phthalocyanines; porphyrins; purpurins; texaphyrins; and any other agent that absorbs light in a range of 500 nm-1100 nm. A preferred embodiment contemplates that the photosensitizing agent is indocyanine green (ICG).

Other embodiments are drawn to the presently disclosed methods of transcutaneous PDT, where the light source is positioned in proximity to the target tissue of the subject and is selected from the group consisting of: an LED light source; an electroluminescent light source; an incandescent light source; a cold cathode fluorescent light source; organic polymer light source; and inorganic light source. A preferred embodiment includes the use of an LED light source.

Yet other embodiments of the presently disclosed methods are drawn to use of light of a wavelength that is from about 500 nm to about 1100 nm, preferably greater than about 650 nm and more preferably greater than about 700 nm. A preferable embodiment of the present method is drawn to the use of light that results in a single photon absorption mode by the photosensitizing agent.

Additional embodiments include compositions of photosensitizer targeted delivery system comprising: a photosensitizing agent and a ligand that binds a receptor on the target tissue with specificity. Preferably, the photosensitizing agent of the targeted delivery system is conjugated to the ligand that binds a receptor on the target (nerve or adventitial wall of blood vessel) with specificity. More preferably, the ligand comprises an antibody that binds to a receptor. Most preferably, the receptor is an antigen on thick or thin neointimas, intimas, adventitia of arteries, arterial plaques, vascular smooth muscle cells and/or the extracellular matrix of the site to be treated.

A further preferred embodiment contemplates that the photosensitizing agent is selected from the group consisting of: indocyanine green (ICG); methylene blue; toluidine blue; aminolevulinic acid (ALA); chlorin compounds; phthalocyanines; porphyrins; purpurins; texaphyrins; and any other agent that absorbs light in a range of 500 nm-1100 nm.

Other photosensitizers that may be used with embodiments described herein are known in the art, including, photofrin. RTM, synthetic diporphyrins and dichlorins, phthalocyanines with or without metal substituents, chloroaluminum phthalocyanine with or without varying substituents, chloroaluminum sulfonated phthalocyanine, O-substituted tetraphenyl porphyrins, 3,1-meso tetrakis (o-propionamido phenyl) porphyrin, verdins, purpurins, tin and zinc derivatives of octaethylpurpurin, etiopurpurin, hydroporphyrins, bacteriochlorins of the tetra(hydroxyphenyl) porphyrin series, chlorins, chlorin e6, mono-1-aspartyl derivative of chlorin e6, di-l-aspartyl derivative of chlorin e6, tin(IV) chlorin e6, meta-tetrahydroxphenylchlorin, benzoporphyrin derivatives, benzoporphyrin monoacid derivatives, tetracyanoethylene adducts of benzoporphyrin, dimethyl acetylenedicarboxylate adducts of benzoporphyrin, Diels-Adler adducts, monoacid ring “a” derivative of benzoporphyrin, sulfonated aluminum PC, sulfonated AIPc, disulfonated, tetrasulfonated derivative, sulfonated aluminum naphthalocyanines, naphthalocyanines with or without metal substituents and with or without varying substituents, zinc naphthalocyanine, anthracenediones, anthrapyrazoles, aminoanthraquinone, phenoxazine dyes, phenothiazine derivatives, chalcogenapyrylium dyes, cationic selena and tellurapyrylium derivatives, ring-substituted cationic PC, pheophorbide derivative, pheophorbide alpha and ether or ester derivatives, pyropheophorbides and ether or ester derivatives, naturally occurring porphyrins, hematoporphyrin, hematoporphyrin derivatives, hematoporphyrin esters or ethers, protoporphyrin, ALA-induced protoporphyrin IX, endogenous metabolic precursors, 5-aminolevulinic acid benzonaphthoporphyrazines, cationic imminium salts, tetracyclines, lutetium texaphyrin, tin-etio-purpurin, porphycenes, benzophenothiazinium, pentaphyrins, texaphyrins and hexaphyrins, 5-amino levulinic acid, hypericin, pseudohypericin, hypocrellin, terthiophenes, azaporphyrins, azachlorins, rose bengal, phloxine B, erythrosine, iodinated or brominated derivatives of fluorescein, merocyanines, nile blue derivatives, pheophytin and chlorophyll derivatives, bacteriochlorin and bacteriochlorophyll derivatives, porphocyanines, benzochlorins and oxobenzochlorins, sapphyrins, oxasapphyrins, cercosporins and related fungal metabolites and combinations thereof.

Several photosensitizers known in the art are FDA approved and commercially available. In a preferred embodiment, the photosensitizer is a benzoporphyrin derivative (“BPD”), such as BPD-MA, also commercially known as BPD Verteporfin or “BPD” (available from QLT). U.S. Pat. No. 4,883,790 describes BPD compositions. BPD is a second-generation compound, which lacks the prolonged cutaneous phototoxicity of Photofrin® (Levy (1994) Semin Oncol 21: 4-10). BPD has been thoroughly characterized (Richter et al., (1987) JNCI 79:1327-1331), (Aveline et al. (1994) Photochem Photobiol 59:328-35), and it has been found to be a highly potent photosensitizer for PDT.

In a preferred embodiment, the photosensitizer is tin ethyl etiopurpurin, commercially known as purlytin (available from Miravant).

In some embodiments, external neuromodulation is performed in which low energy ultrasound is applied to the nerve region to modulate the nerves. For example, it has been shown in the past that low intensity (e.g. non-thermal) ultrasound can affect nerves at powers which range from 30-500 W/Cm²whereas HIFU (thermal modulation), which by definition generates heat at a focus point, requires power levels exceeding 1000 W/Cm². The actual power flux to the region to be ablated is dependent on the environment including surrounding blood flow and other structures. With low intensity ultrasound, the energy does not have to be so strictly focused to the target because it's a non-ablative energy; that is, the vibration or mechanical pressure may be the effector energy and the target may have a different threshold for effect depending on the tissue. However, even low energy ultrasound may require focusing if excessive heat to the skin is a worry or if there are other susceptible structures in the path and only a pinpoint region of therapy is desired. Nonetheless, transducers 500 in FIG. 1a provide the ability to apply a range of different energy and power levels as well as modeling capability to target different regions and predict the response.

In FIG. 1a, and in one embodiment, a renal artery 640 is detected with the assistance of imaging devices 600 such as Doppler ultrasound, infrared imaging, thermal imaging, B-mode ultrasound, MRI, or a CT scan. With an image of the region to be treated, measurements in multiple directions on a series of slices can be performed so as to create a three-dimensional representation of the area of interest. By detecting the position of the renal arteries from more than one angle via Doppler triangulation (for example) or another triangulation technique, a three dimensional positional map can be created and the renal artery can be mapped into a coordinate reference frame. In this respect, given that the renal nerves surround the renal blood vessels in the hilum, locating the direction and lengths of the blood vessels in three dimensional coordinate reference is the predominant component of the procedure to target these sympathetic nerves. Within the three dimensional reference frame, a pattern of energy can be applied to the vicinity of the renal artery from a device well outside the vicinity (and outside of the patient altogether) based on knowledge of the coordinate reference frame.

For example, once the renal artery is placed in the coordinate reference frame with the origin of the energy delivery device, an algorithm is utilized to localize the delivery of focused ultrasound to heat or apply mechanical energy to the adventitia and surrounding regions of the artery which contain sympathetic nerves to the kidney and afferent nerves from the kidney, thereby decreasing the sympathetic stimulus to the kidney and decreasing its afferent signaling back to the autonomic nervous system via the central nervous system; affecting these targets will modulate the propensity toward hypertension which would otherwise occur. The ultrasonic energy delivery can be modeled mathematically by predicting the acoustic wave dissipation using the distances and measurements taken with the imaging modalities of the tissues and path lengths.

Furthermore, a system such as acoustic time of flight can be utilized to quantitatively determine the distance from a position on the therapeutic transducer to the region of the blood vessel to the kidney. Such a system allows for detection of a distance using an ultrasound pulse. The distance obtained as such is then utilized for the therapeutic ultrasound treatment because the tissues and structures which are interrogated are the same ones through which the therapeutic ultrasound will travel, thereby allowing essentially auto-calibration of the therapeutic ultrasound pulse.

For example, FIG. 1D depicts a system with an integral catheter 652 and one or more transducers 654 on the catheter. Electrical impulses are sent from a generator 653 to the catheter 652 and to the transducers 654 which may be piezoelectric crystals. Detectors 650 detect the distance 656 from the piezoelectric transducers as well as the 3-dimensional orientation and exact position of the transducers 654. With positional information in three dimensional space, focused ultrasound transducer 662 can be directed toward the target under the direction of motion controllers/transducer(s) 660. In some embodiments, a single transducer (internal) 654 is detected. In other embodiments, multiple transducers 654 are detected. In the embodiment in which multiple transducers are utilized, more detail around the three dimensional position and orientation of the vessel is available allowing for a redundant approach to position detection. In either case, by pulling back the catheter within the blood vessel while applying electrical signals to the piezoelectric crystal so that they may be detected outside the patient, the three dimensional anatomy of the vessel can be mapped and determined quantitatively so that treatment can be applied at an exact location along the blood vessel. In this method, a guidewire is placed at the site of treatment and then moved to different positions close to the treatment site (e.g. within a blood vessel). During the movement along the blood vessel, the detectors outside the patient are mapping the movement and the region of treatment. The map of the blood vessel (for example) is then used to perform the treatment in the exact region planned with a high degree of accuracy due to the mapping of the region. Signal generator 653 may create signals with frequencies ranging from 0.5 MHz up to 3 MHz (or any frequency value in this range), or even a wider range of frequencies to ensure detection of the orientation. With positional information regarding the catheter in the blood vessel (that is, the three dimensional coordinates of the energy transmitter 654), virtually any energy pattern can be created around the blood vessel, any distance from the blood vessel. With information regarding the anatomy of the blood vessel, a complex pattern can be created around the catheter and hence the blood vessel. The pattern can be a V shaped pattern in the example where the blood vessel has an early bifurcation. It can be a tortuous pattern along or surrounding the blood vessel.

In one embodiment of an algorithm, the Doppler signal from the artery is identified from at least two different directions and the direction of the artery is reconstructed in three dimensional space. In this example, acoustic time of flight may be utilized via the Doppler ultrasound of the flow signal, or via a piezoelectric transducer (internal) and receiver (external) 650 set up. With two points in space, a line is created and with knowledge of the thickness of the vessel, a tube, or cylinder, can be created to represent the blood vessel as a virtual model. The tube is represented in three dimensional space over time and its coordinates are known relative to the therapeutic transducers outside of the skin of the patient. Therapeutic energy can be applied from more than one direction as well and can focus on the cylinder (blood anterior vessel wall, central axis, or posterior wall). With a third point, the position of the target can be precisely localized in the 3D space and targeted with a HIFU transducer 660. Position detection algorithm 666 can be utilized to compare the baseline position of the catheter 654 to a position after a period of time so as to detect respiratory and patient movement. In one embodiment, the therapeutic HIFU array 662 is also used to send a signal out for imaging (diagnostic pulse). For example, any number of elements can be activated via the power supply 665 from the HIFU array to deposit energy into the tissue. Such energy deposition can be advantageous because it is by definition focused on the region 664 that will ultimately be treated. The return signal is likewise detected by the same ultrasound elements which generate the HIFU pulse, or may be detected by other imaging receivers 668. In this respect, by definition the exact region of treatment can be interrogated with the focused ultrasound pulse from the therapeutic array 662 and this allows for highly specialized imaging of the region of interest. Therefore, in one embodiment, an ultrasound system is utilized in which a focused ultrasound pulse is applied to a target prior to treatment of the target. The focused ultrasound pulse is of short duration and its reflection from the target is utilized to characterize the target (e.g., it may be used to determine image properties, tissue properties, degree of damage after a treatment, position within the body of a patient, temperature, three dimensional position, etc, for the target); it may also detect a blood vessel via Doppler signal 670. With this precise information about the target, a therapeutic ultrasound pulse from the therapeutic transducer may then be applied to the target to inhibit nerves, ablate nerves, or vibrate nerves, etc. Alternatively, or additionally, pharmaceuticals may be delivered. Parameters in addition to imaging include Doppler flow, tissue elastography, stress strain curves, ultrasound spectroscopy, and targeting of therapeutics to the region. The therapeutic array 662 can be utilized as a receiver for the diagnostic signal or a separate detector can be utilized as the receiver. In some embodiments, the catheter may be adapted to deliver pharmaceuticals to the region as well as to assist in beam focusing. A Doppler targeting algorithm may complement the catheter 652 based targeting. Power supply is configured to apply the proper power to the HIFU transducer to treat a blood vessel deep within a patient. For example, the power input into the HIFU transducer might be 150 W, 200 W, 500 W, 750 W, or greater than 1000 W to achieve output suitable for deep treatment in a patient. Pulsing frequency of the HIFU treatment may be as fast as 10 Hz or even 1 KHz. The catheter may deliver short ultrasound bursts at similar frequencies, that is, 10 Hz, 50 Hz, 100 Hz, of even 1 kHz. The piezoelectric signal may be detected from more than one direction outside the body of the patient. For example, there may be more than 1 receiver 650; for example, 3 receivers, 8 receivers, or even greater than 10 receivers 650. One or more modes of ultrasound may be utilized and detected from different directions outside the skin of the patient. Very large impulses may be generated in the first few microseconds of the piezoelectric impulse delivery. For example, in some embodiments, 8 W/Cm2 may be generated for a few microseconds and then the voltage may be quickly decreased to zero until the next cycle (<1% duty cycle). First, second, third, or even higher harmonics might be detected from outside the patient. The piezoelectric pulse might last for 10 s and then therapy applied for 20-40 ms for a duty cycle of 20%-50%. Such a duty cycle allows for an adequate blend of position signaling versus therapy, the therapy being delivered based on the signal position.

In some embodiments, the catheter contains a dosimeter to detect the power or temperature of the focused ultrasound. The catheter can also direct the HIFU in a passive sense. For example, imaging can be used to image a fiducial on the catheter so that the fiducial provides a method to image the target from outside. Once imaged, the blood vessel can be targeted by creating a treatment plan around the imaged catheter.

Focused energy (e.g. ultrasound) can be applied to the center of the vessel (within the flow), on the posterior wall of the vessel, in between (e.g. when there is a back to back artery and vein next to one another) the artery vessel and a venous vessel, etc. A processor 668 directs the mover 660 to position the focused ultrasound array 662 to a position relative to the target 664. Mover 660 directs the ultrasound focus based on position 666 of the catheter 652 relative to the ultrasound array 660. In some embodiments, a Doppler signal 670 is used with/combined in the system or used by itself to direct the ultrasound array. The mover 660 can create a pattern on or around the vessel of interest or even at a position distant from the vessel (e.g. 1-2 cm distant from the vessel) and around the vein in some examples.

Imaging 600 (FIG. 1C) of the sympathetic nerves or the sympathetic region (the target) is also utilized so as to assess the direction and orientation of the transducers relative to the target 620; the target is an internal fiducial, which in one embodiment is the kidney 610 and associated renal artery 620 because they can be localized via their blood flow, a model then produced around it, and then they both can be used as a target for the energy. Continuous feedback of the position of the transducers 500, 510 relative to the target 620 is provided by the imaging system, wherein the position may be in the coordinate space of the imaging system, for example. The imaging may be a cross-sectional imaging technology such as CT or MRI or it may be an ultrasound imaging technology which yields faster real time imaging. In some embodiments, the imaging may be a combination of technologies such as the fusion of MRI/CT and ultrasound. The imaging system can detect the position of the target in real time at frequencies ranging from 1 Hz to thousands and tens of thousands of images per second.

In the example of fusion, cross-sectional imaging (e.g. MRI/CT) is utilized to place the body of the patient in a three dimensional coordinate frame and then ultrasound is linked to the three dimensional reference frame and utilized to track the patient's body in real time under the ultrasound linked to the cross-sectional imaging. The lack of resolution provided by the ultrasound is made up for by the cross-sectional imaging since only a few consistent anatomic landmarks are required for an ultrasound image to be linked to the MRI image. As the body moves under the ultrasound, the progressively new ultrasound images are linked to the MRI images and therefore MRI “movement” can be seen at a frequency not otherwise available to an MRI series.

In one embodiment, ultrasound is the energy used to inhibit nerve conduction in the sympathetic nerves. In one embodiment, focused ultrasound (HIFU) from outside the body through the skin is the energy used to inhibit sympathetic stimulation of the kidney by delivering waves from a position external to the body of a patient and focusing the waves on the sympathetic nerves on the inside of the patient and which surround the renal artery of the patient. MRI may be used to visualize the region of treatment either before, during, or after application of the ultrasound. MRI may also be used to heat a targeting catheter in the region of the sympathetic nerves. For example, a ferromagnetic element on the tip of a catheter will absorb energy in the presence of a magnetic field and heat itself, thereby enabling heat to be applied to the nerves surrounding the blood vessels leading to the kidney. The heatable catheter may also be configured (e.g., shaped) to create an inductance circuit when the magnetic field is applied across it. Shapes include loops, tapers, sharp turns, twists, etc. When such a shaped catheter is placed within a magnetic field, heating is created at the catheter level. Alternatively, the focused ultrasound can be utilized to heat the catheter. For example, focused ultrasound can be delivered through the skin of a patient to a catheter inside a vessel, the catheter absorbing or reflecting energy to a region outside the blood vessel.

FIG. 1E depicts an overview of the software subsystems 675 to deliver a safe treatment to a patient. An executive control system 677 contains an operating system, a recording of the system functions, a network connection, and other diagnostic equipment. Communication with treatment dosimetry plan 681 may be accomplished via modeling and previously obtained empirical data. The software within the dosimetry plan allows for further communication with the acoustic time of flight transducer (ATOF) 679 and the motion controller for the diagnostic and therapeutic arrays. Target localization based on acoustic time of flight (ATOF) can provide accurate and robust position sensing of target location relative to the therapeutic ultrasound transducer. Direct X, Y and Z (i.e. three-dimensional) coordinate locations of the target can be provided without the need for image interpretation. Three-dimensional targeting information facilitates the use of an explicit user interface to guide operator actions. ATOF is less sensitive to variations in patient anatomy as compared to imaging techniques. ATOF can be accomplished with a relatively simple and inexpensive system compared to the complex imaging systems used by alternate techniques. In some embodiments, continuous tracking of the target in the presence of movement between the target and the external transducer may be provided 676. In some embodiments, ATOF allows use of system architectures that utilize a larger fraction of the patient contact area to generate therapeutic power (as contrasted with imaging based alternatives which occupy some space within the therapeutic transducer for diagnostic power)—thus reducing the power density applied to the patient's skin.

In another embodiment, the ATOF sensors assist in the determination of the pathway for the therapeutic ultrasound. For example, an ultrasound pulse may be generated within the blood vessel, and one or more aspects (e.g., the pathlength, quality, speed, etc.) of the sound from the transducer is detected by receivers outside the patient. Based on one or more of these parameters and variables, the path of the HIFU may be determined such that a safe and efficient path is transmitted to the target at the blood vessel.

As is depicted in FIG. 3a-b, transducers 900 can emit ultrasound energy from a position outside the patient to the region of the renal sympathetic nerves at the renal pedicle 200. As shown in FIG. 1a, an image of the renal artery 600 using an ultrasound, MRI, or CT scan can be utilized to determine the position of the kidney 610 and the renal artery 620 target. Doppler ultrasound can be used to determine the location and direction of a Doppler signal from an artery and place the vessel into a three dimensional reference frame 950, thereby enabling the arteries 200 and hence the sympathetic nerves 220 (FIG. 3a) around the artery to be much more visible so as to process the images and then utilize focused external energy to pinpoint the location and therapy of the sympathetic nerves. In this embodiment, ultrasound is likely the most appropriate imaging modality. Ultrasound can refer to simple single dimensional pulse echos (A-mode), or devices which scan a region and integrate pulse echos into an image (termed B-mode).

FIG. 1A also depicts the delivery of focused energy to the sympathetic nerve trunks and ganglia 622 which run along the vertebral column and aorta 300; the renal artery efferent nerves travel in these trunks and synapse to ganglia within the trunks. In another embodiment, ablation of the dorsal and ventral roots at the level of the ganglia or dorsal root nerves at T9-T11 (through which the afferent renal nerves travel) would produce the same or similar effect to ablation at the level of the renal arteries.

In another embodiment, FIG. 1B illustrates the application of ionizing energy to the region of the sympathetic nerves on the renal arteries 620 and/or renal veins. In general, energy levels of greater than 20 Gy (Gray) are required for linear accelerators or low energy x-ray machines to ablate nervous tissue using ionizing energy; however, lower energy is required to stun, inhibit nervous tissue, or prevent re-growth of nervous tissue; in some embodiment, ionizing energy levels as low as 2-5 Gy or 5-10 Gy or 10-15 Gy are delivered in a single or fractionated doses. Ionizing energy can be applied using an orthovoltage X-ray generator, a linear accelerator, brachytherapy, and/or an intravascular X-ray radiator which delivers electronic brachytherapy. X-rays such as from a linear accelerator or from an orthovoltage x-ray generator can be delivered through the skin from multiple directions to target nerves surrounding a blood vessel. In one example, the blood vessel might be a renal artery or renal vein with nerves running around it. By targeting the blood vessel, ionizing energy can be applied to the nerves surrounding the blood vessel. Ultrasound, Doppler imaging, angiograms, fluoroscopy, CT scans, thermography imaging, and MRIs can be utilized to direct the ionizing energy.

Combinations of ionizing energy and other forms of energy can be utilized in this embodiment as well so as to prevent re-growth of the nervous tissue. For example, a combination of heat and/or vibration and/or cavitation and/or ionizing radiation might be utilized to prevent re-growth of nervous tissue after the partial or full ablation of the nervous tissue surrounding the renal artery. Combinations of pharmaceutical agents can be combined with one another or with device and physical means to prevent or initially inhibit nerve tissue and/or regrowth of nerve tissue. For example, a steroid might be applied to the region around the blood vessel either via catheter or systemically, then the region is heated with ultrasound. Similarly, a neurotoxin might be applied to the region, and then ultrasound is applied to the region of the nerves being treated (e.g., to interact with the neurotoxin to activate it, and/or to treat the nerves in conjunction with the neurotoxin).

FIG. 2 illustrates the renal anatomy and surrounding anatomy with greater detail in that organs such as the stomach 700 are shown in its anatomic position overlying the abdominal aorta 705 and renal arteries 715. In this embodiment, energy is delivered through the stomach to reach an area behind the stomach. In this embodiment, the stomach is utilized as a conduit to access the celiac ganglion 710, a region which would otherwise be difficult to reach. The aorta 705 is shown underneath the stomach and the celiac ganglion 710 is depicted surrounding the superior mesenteric artery and aorta. A transorally placed tube 720 is placed through the esophagus and into the stomach. The tube overlies the celiac ganglion when placed in the stomach and can therefore be used to deliver sympatholytic devices or pharmaceuticals which inhibit or stimulate the autonomic celiac ganglia behind the stomach; these therapies would be delivered via transabdominal ultrasound or fluoroscopic guidance (for imaging) through the stomach. Similar therapies can be delivered to the inferior mesenteric ganglion, renal nerves, or sympathetic nerves traveling along the aorta through the stomach or other portion of the gastrointestinal tract. The energy delivery transducers 730 are depicted external to the patient and can be utilized to augment the therapy being delivered through the stomach to the celiac ganglion. Alternatively, the energy delivery transducers can be utilized for imaging the region of therapy. For example, an ultrasound transducer can be utilized to image the aorta and celiac ganglion and subsequently to apply ultrasound energy to the region to inhibit the nerves in the region. In some cases, ablation is utilized and in other cases, vibration is utilized to inhibit the nerves from functioning.

In one embodiment, energy is applied to the region of the celiac ganglion from a region outside the patient. In this embodiment, fluid is placed into the gastrointestinal system, such as for example, in the stomach or small intestine. Ultrasound can then be transmitted through the gastrointestinal organs to the ganglia of interest behind the stomach.

Temporary neurostimulators can also be placed through the tube placed into the esophagus and into the stomach, such as, for example, in an ICU setting where temporary blockage of the autonomic ganglia may be required. Temporary neurostimulators can be used to over pace the celiac ganglion nerve fibers and inhibit their function as a nerve synapse. Inhibition of the celiac ganglion may achieve a similar function as ablation or modulation of the sympathetic nerves around the renal arteries. That is, the decrease in the sympathetic activity to the kidneys (now obtained with a more proximal inhibition) leads to the lowering of blood pressure in the patient by decreasing the degree of sympathetic outflow from the sympathetic nerve terminals. In the celiac ganglia, the blood pressure lowering effect is more profound given that the celiac ganglia are pre-ganglionic and have more nerve fibers to a greater number of regions than each renal nerve. The effect is also likely more permanent than the effect on the post-ganglionic nerve fibers.

FIG. 3A illustrates the renal anatomy more specifically in that the renal nerves 220 extending longitudinally along the renal artery 200, are located generally within, or just outside the adventitia, of the outer portion of the artery. Arteries are typically composed of three layers: the first is the intimal, the second is the media, and the third is the adventitia. The outer layer, the adventitia, is a fibrous tissue which contains blood vessels and nerves. The renal nerves are generally postganglionic sympathetic nerves although there are some ganglia which exist distal to the takeoff from the aorta such that some of the nerve fibers along the renal artery are in fact pre-ganglionic. By the time the fibers reach the kidney, the majority of the fibers are post-ganglionic. The afferent nerves on the other hand leave the kidney and are post-ganglionic up to the level of the brain. These fibers do not re-grow as quickly as the efferent fibers, if at all.

Energy generators 900 deliver energy to the renal nerves accompanying the renal artery, depositing energy from multiple directions to target inhibition of the renal nerve complex. The energy generators can deliver ultrasound energy, ionizing radiation, light (photon) therapy, or microwave energy to the region. The energy can be non-focused in the case where a pharmaceutical agent is targeted to the region to be ablated or modulated. Preferably, however, the energy is focused, being applied from multiple angles from outside the body of the patient to reach the region of interest (e.g. sympathetic nerves surrounding blood vessels). The energy transducers 900 are placed in an X-Y-Z coordinate reference frame 950, as are the organs such as the kidneys. The x-y-z coordinate frame is a real space coordinate frame. For example, real space means that the coordinate reference is identifiable in the physical world; like a GPS (global positioning system), with the physical coordinates, a physical object can be located. Once in the x-y-z coordinate reference frame, cross-sectional imaging using MRI, CT scan, and/or ultrasound is utilized to couple the internal anatomy to the energy transducers. These same transducers may be utilized for the determination of the reference point as well as the therapy. The transducers 900 in this embodiment are focused on the region of the renal nerves at the level of the renal blood vessels, the arteries and veins 200. The focus of the beams can be inside the artery, inside the vein, on the adventitia of the artery or adventitia of the vein.

When applying ultrasonic energy across the skin to the renal artery region, energy densities of potentially over 1 kW/cm²might be required at region of interest in the adventitia of the blood vessel. Typically, however, power densities of 100 W/cm²to 900 kW/cm²would be expected to create the heating required to inhibit these nerves (see Foley et. al. Image-Guided HIFU Neurolysis of Peripheral Nerves To Treat Spasticity And Pain; Ultrasound in Med & Biol. Vol 30 (9) p 1199-1207). The energy may be pulsed across the skin in an unfocused manner; however, for application of heat, the transducers must be focused otherwise the skin and underlying tissues will receive too much heat. Under imaging with MRI, temperature can be measured with the MRI image. When low energy ultrasound is applied to the region, energy (power) densities in the range of 50 mW/cm²to 500 mW/cm²may be applied. Low energy ultrasound may be enough to stun or partially inhibit the renal nerves particularly when pulsed and depending on the desired clinical result. High intensity ultrasound applied to the region with only a few degrees of temperature rise may have the same effect and this energy range may be in the 0.1 kW/cm2 to the 500 kW/cm2 range. A train of pulses also might be utilized to augment the effect on nervous tissue. For example, a train of 100 short pulses, each less than a second and applying energy densities of 1 W/cm²to 500 W/cm². In some of the embodiments, cooling may be applied to the skin if the temperature rise is deemed too large to be acceptable. In some embodiments, infrared thermography is utilized to determine the temperature of the skin and subcutaneous tissues, or if detected from deeper within, from the kidneys and even renal blood vessels themselves. Alternatively, the ultrasound transducers can be pulsed or can be alternated with another set of transducers to effectively spread the heat across the surface of the skin. In some embodiments, the energy is delivered in a pulsed fashion to further decrease the risk to the intervening tissues between the target and the transducer. The pulses can be as close as millisecond, as described, or as long as hours, days or years.

In one method of altering the physiologic process of renal sympathetic excitation, the region around the renal arteries is imaged using CT scan, MRI, thermography, infrared imaging, optical coherence tomography (OCT), photoacoustic imaging, pet imaging, SPECT imaging, or ultrasound, and the images are placed into a three dimensional coordinate reference frame 950. The coordinate reference frame 950 refers to the knowledge of the relationship between anatomic structures, both two dimensional and three dimensional, the structures placed into a physical coordinate reference. Imaging devices determine the coordinate frame. Once the coordinate frame is established, the imaging and therapy transducers 900 can be coupled such that the information from the imaging system is utilized by the therapeutic transducers to position the energy. Blood vessels may provide a useful reference frame for deposition of energy as they have a unique imaging signature. An ultrasound pulse echo can provide a Doppler shift signature to identify the blood vessel from the surrounding tissue. In an MRI, CT scan, and even an ultrasound exam, intravenous contrast agents can be utilized to identify flow patterns useful to determine a coordinate reference for energy deposition. Energy transducers 900 which can deliver ultrasound, light, radiation, ionizing radiation, or microwave energy are placed in the same three-dimensional reference frame as the renal arteries, at which time a processor (e.g. using an algorithm) can determine how to direct the transducers to deliver energy to the region 220 of the nerves 910. The algorithm consists of a targeting feature (planning feature) which allows for prediction of the position and energy deposition of the energy leaving the transducers 900.

Once the three dimensional coordinate reference frames 950 are linked or coupled, the planning and prediction algorithm can be used to precisely position the energy beams at a target in the body.

The original imaging modality can be utilized to locate the renal sympathetic region, and/or can be used to track the motion of the region during treatment. For example, the imaging technology used at time zero is taken as the baseline scan and subsequent scans at time t1 are compared to the baseline scan, t0 (start). The frequency of updates can range from a single scan every few seconds to many scans per second. With ultrasound as the imaging technology, the location might be updated at a frame rate greater than 50 Hz and up to several hundred Hz or thousand Hz. With MRI as the imaging modality, the imaging refresh rate might be closer to 30 Hz. In other embodiments, internally placed fiducials transmit positional information at a high frequency and this information is utilized to fuse the target with an initial external imaging apparatus. Internal fiducials might include one or more imageable elements including doppler signals, regions of blood vessels, ribs, kidneys, and blood vessels and organs other than the target (e.g. vena cava, adrenal gland, ureter). These fiducials can be used to track the region being treated and/or to triangulate to the region to be treated. The fiducials can be placed externally to an internal position or might be intrinsic fiducials such as anatomic features and/or imageable features.

In some embodiments (FIG. 3C), a temporary fiducial 960 is placed in the region, such as in the artery 965, renal vein 975, aorta 945, and/or vena cava 985; such a fiducial is easily imageable from outside the patient. In one embodiment, the temporary fiducial may enhance imaging such as a balloon fillable with gas or bubbles. In another embodiment, the temporary fiducial may be a material imageable via MRI or ultrasound.

FIG. 3D depicts an imageable transducer 960 in a blood vessel 967 within a coordinate reference 975 on a monitor system 950. Alternatively, the temporary fiducial 960 is a transducer which further improves the ability to image and track the region to deliver therapy. The transducer may be a piezoelectric crystal which is stimulated to emit energy which can be detected by one or more detectors to determine a three dimensional position. The receivers are placed outside the patient in some embodiments, and their geometry determines the sensitivity and position of the transducer within the coordinate reference. The transducer may release radiofrequency energy which can be detected by one or more detectors to pinpoint a three dimensional position. The transducer may emit an audible sound or an optical signal. The temporary fiducial might be a mechanical, optical, electromechanical, a radiofrequency radiotransmitter, an ultrasound generator, a global positioning tracking (GPS) device, or ultrasound responsive technology. Similar devices that may be used to assist in performing the treatment described herein might be found in U.S. Pat. Nos. 6,656,131 and 7,470,241 which are incorporated by reference herein.

Internal reflections (e.g. speckles) can be tracked as well. These speckles are inherent characteristics of tissue as imaged with ultrasound. They can be tracked and incorporated into treatment planning algorithm and then linked to the therapeutic transducers. Alternatively, edge detection might be used to detect the edge of a blood vessel in a B-mode or a color Doppler ultrasound image. The edge detection algorithm can be used to track the vessel while therapeutic ultrasound is being applied to the region around the vessel. In some embodiments, cavitation is detected, in which vapor bubbles are detected to determine temperature or degree of heating.

In some embodiments, a test dose of energy can be applied to the renal sympathetic region and then a test performed to determine if an effect was created. For example, a small amount of heat or vibratory energy can be delivered to the region of the sympathetic nerves and then a test of sympathetic activity such as microneurography (detection of sympathetic nerve activity around muscles and nerves which correlate with the beating heart) can be performed. Past research and current clinical data have shown that the sympathetic nerves to the peripheral muscles are affected by interruption of the renal afferent nerves. The degree of temperature rise with the small degree of heat can be determined through the use of MRI thermometry or an ultrasound technique and the temperature rise can be determined or limited to an amount which is reversible. The stimulus might be a simple pulse of ultrasound such that the mechanical effect of the ultrasound stimulates the sympathetic system. The pure mechanical effect of the ultrasound might be enough to stimulate the sympathetic system leading to the kidney. Parameters such as blood flow inside the kidney, spasm of blood vessels, systolic to diastolic ratios, systemic blood pressure response, etc. might be useful to determine or predict effect of the therapy.

In another embodiment, a stimulus is applied to a region such as the skin and an output downstream from the skin is detected. For example, a vibratory energy might be applied to the skin and a sympathetic outflow such as the heart rate might be detected. In another embodiment, heat or cold might be applied to the skin and heart rate, blood pressure; vasoconstriction might be detected as an output. These input-output relationships may be affected by the treatments described herein. In some embodiments, the treatments described herein may be dictated at least in part by the input-output relationships.

Alternatively, ultrasonic imaging can be utilized to determine the approximate temperature rise of the tissue region. The speed of ultrasonic waves is dependent on temperature and therefore the relative speed of the ultrasound transmission from a region being heated will depend on the temperature, therefore providing measureable variables to monitor. In some embodiments, microbubbles are utilized to determine the rise in temperature. Microbubbles expand and then degrade when exposed to increasing temperature so that they can then predict the temperature of the region being heated. The microbubbles can be injected into the vein or artery of a patient or the microbubbles can be injected locally into the aorta, renal artery, renal vein, etc. A technique called ultrasound elastography can also be utilized. In this embodiment, the elastic properties of tissue are dependent on temperature and therefore the elastography may be utilized to track features of temperature change. The microbubbles can also be utilized to augment the therapeutic effect of the region being targeted. For example, the microbubbles can be utilized to release a pharmaceutical when the ultrasound reaches them. Pharmaceuticals which can be released include steroids, neurotoxins, neuromodulating medicaments, nanoparticles, antibodies, magnetic nanoparticles, polymeric nanoparticles, etc. Alternatively, the microbubble structure can be utilized to enhance imaging of the treatment region to improve targeting or tracking of the treatment region.

In some embodiments, only the temperature determination is utilized. That is, the temperature sensing embodiments and algorithms described herein are utilized with any procedure in which heating is being performed. For example, in a case where heating of the renal nerve region is performed using radiofrequency ablation through the renal artery, imaging of the region from a position external to the patient can be performed while the renal artery region is being heated via radiofrequency methods. Imaging can be accomplished utilizing MRI, ultrasound, infrared, or OCT methods. Imaging can be utilized to determine temperature or an effect of temperature on the regions surrounding the blood vessel and/or nerves. For example, a radiofrequency catheter can be utilized to apply energy to the wall of a blood vessel and then ultrasound imaging can be applied during or after the treatment with the radiofrequency catheter, at which point temperature, coagulation status, and nerve damage can be determined around the blood vessel with the nerve. In addition or alternatively, MRI can be utilized to determine temperature or map effect on the nerve structures surrounding the blood vessels during the radiofrequency heating of the blood vessel.

Such imaging of the treatment can assist in the directing of precise treatment to the region around the blood vessel, and allow for safe application of heat to the blood vessel wall. For example, in one embodiment, energy is applied to the wall of the blood vessel and the heat is detected during the treatment. The temperature in such an embodiment can be limited with a specified level (e.g. 55 degrees, 60 degrees, 65 degrees) for a specific amount of time (e.g. 30 seconds, 60 seconds, 120 seconds). MRI or ultrasound or both can be used for this treatment and/or for measurement. In this method the localization of the heat about the wall of the blood vessel can be determined.

In another embodiment, a test may be performed on the baroreceptor complex at the region of the carotid artery bifurcation. After the test dose of energy is applied to the renal artery complex, pressure can be applied to the carotid artery complex; typically, with an intact baroreceptor complex, the systemic blood pressure would decrease after application of pressure to the carotid artery. However, with renal afferent nerves which have been inhibited, the baroreceptors will not be sensitive to changes in blood pressure and therefore the efficacy of the application of the energy to the renal nerves can be determined. Other tests include attaining indices of autonomic function such as microneurography, autonomic function variability, etc. In one method, these tests of autonomic or baroreceptor dysfunction is utilized to assist in the selection of patients who will respond to sympathetic nerve ablation.

In another embodiment, stimulation of the baroreceptor complex is accomplished non-invasively via ultrasound pulses applied externally to the region of the carotid body. The ultrasound pulses are sufficient to stimulate the sinus to affect a blood pressure change, a change which will be affected when an afferent nerve such as the renal afferents have been altered.

More specifically, this methodology is depicted in FIG. 3E. An ultrasound pulse 980 is utilized to stimulate the carotid sinus or carotid body (collectively termed the baroreceptor complex) which will lower blood pressure transiently 982 by activating the baroreceptor complex; activation of the carotid sinus 980 simulates the effect of an increase in blood pressure which leads to a compensatory outflow of parasympathetic activity and decreased sympathetic outflow, subsequently lowering blood pressure. In the instance when the afferent system (e.g. from the kidney) has been inhibited, the pressure will not be modifiable as quickly if at all. In this case, stimulating the baroreceptor complex does not result in a lowering of blood pressure 986, then the treatment was successful. This diagnostic technique can therefore be utilized to determine the effect of a therapy on a system such as the renal nerve complex. If therapy is successful, then the modifying effect of the ultrasound pulse on the carotid sinus and blood pressure is less dramatic and the therapeutic (treatment of afferent nerves) successful; therefore, therapy can be discontinued 988 temporarily or permanently. If the blood pressure continues to decrease 982 with the baroreceptor stimulation, then the therapeutic effect has not been reached with the therapeutic treatment and it needs to be continued 984 and/or the dose increased. Other methods to stimulate the baroreceptor complex are to apply pressure in the vicinity with hands, compression balloons, electrical stimulators, and the like. Stimulation of the sinus can accomplished by a sharp pulse of ultrasound, radiofrequency, light, or other accessible energy source. Once the parameter is determined to have been affected by ultrasound, the full therapy of the region can be completed.

Other regions of the autonomic nervous system can also be affected directly by the technology described herein by applying energy from one region and transmitted through tissue to another region. For example, FIG. 4A illustrates a system in which energy external to the internal carotid artery is applied to a portion of the autonomic nervous system, the carotid body complex 1000, through the internal jugular vein 1005, and to the carotid body 1000 and/or vagus nerve region 1022, and/or vertebral artery 1015. Ablative energy, vibratory, or electrical stimulation energy can be utilized to affect the transmission of signals to and from these nerves. The transmission in this complex can be augmented, interrupted, inhibited with over-stimulation, or a combination of these effects via energy (e.g. ultrasound, electrical stimulation, etc.).

In addition, or in place of, in other embodiments, energy may be applied to peripheral nerves typically known as motor nerves but which contain autonomic fibers. Such nerves include the saphenous nerve, femoral nerves, lumbar nerves, median nerves, ulnar nerves, and radial nerves. In some embodiments, energy is applied to the nerves and specific autonomic fibers are affected rather than the other neural fibers (e.g. motor or somatic sensory fibers or efferent or afferent autonomic nerves). In some embodiments, other types of autonomic fibers are affected with energy applied internally or externally. For example, nerves surrounding the superior mesenteric artery, the inferior mesenteric artery, the femoral artery, the pelvic arteries, the portal vein, hepatic artery, pulmonary arteries, pulmonary veins, aorta, vena cava, etc. can be affected by the energy in a specific manner so as to create changes in the autonomic responses of the blood vessels themselves or organs related to the blood vessels, the nerves running through and along the vessels to the organs. Diseases which may be affected by organ specific nerve ablation include heart diseases, respiratory diseases (e.g. COPD, pulmonary hypertension, and Asthma), hypertension, and glaucoma.

In another embodiment, in FIG. 4a, a catheter 1010 is advanced into the internal jugular vein 1005 and when in position, stimulation or ablative energy 1020 is directed toward the autonomic nerves, e.g. the vagus nerve and the carotid sinus/body 1000, from the catheter positioned in the venous system 1005. Delivery of energy to the carotid body complex from outside is potentially safer than delivery from inside the carotid artery given the potential for stroke and intimal hyperplasia subsequent to the procedure.

In a similar type of embodiment 1100, a catheter based therapeutic energy source 1110 can be inserted into the region of the renal arteries or renal veins (FIG. 4B) to stimulate or inhibit the renal nerves from the inside of the vessel, either the renal artery 1105 or renal vein 1106. Energy is transferred through the vessel (e.g. renal vein) to reach the nerves around another vessel (e.g. renal artery). For example, a catheter delivering unfocused ultrasound energy with powers in the range of 50 mW/cm²to 50 kW/cm²can be placed into the renal artery and the energy transmitted radially around the artery or vein to the surrounding nerves. As discussed below, the 500 mW-2500 W/cm²is appropriate to create the specific nerve dysfunction to affect the norepinephrine levels in the kidney, a surrogate of nerve function which has been shown to lead to decreases in blood pressure over time. Pulsed ultrasound, for example, 100 pulse trains with each lasting less than 1 second each, can be applied to the region. In another embodiment, the catheter is composed of individual elements which are organized to create a plane wave. This plane wave may be focused around the catheter through movement and/or through alternative phasing patterns, which place the ultrasound in different position around the circumference of the blood vessel (e.g., artery). The plane wave generating ultrasound catheter delivers vibration and heat to the nerves surrounding the blood vessel.

In an exemplary embodiment, the tubular body 1105 is elongate and flexible, and comprises an outer sheath that is positioned over an inner core. For example, in embodiments particularly well-suited for the renal blood vessels, the outer sheath can comprise extruded polytetrafluoroethylene (“PTFE”), polyetheretherketone (“PEEK”), polyethylene (“PE”), polyamides, braided polyamides and/or other similar materials. In such embodiments, the outer sheath 108 has an outer diameter of approximately 0.039 inch (0.039 inch±0.01 inch) at its proximal end and between approximately 0.033 inch (0.033 inch±0.01 inch) and approximately 0.039 inch (0.039 inch±0.01 inch) at its distal end. In such embodiments, the outer sheath has an axial length of approximately 150 centimeters (150 cm±20 cm). In other embodiments, the outer sheath can be formed from a braided tubing comprising high or low density polyethylenes, urethanes, nylons, and so forth. Such configurations enhance the flexibility of the tubular body 1105. In still other embodiments, the outer sheath can include a stiffening member (not shown) at the tubular body proximal end.

The inner core at least partially defines a central lumen, or “guidewire lumen,” which preferably extends through the length of the catheter. The central lumen has a distal exit port and a proximal access port. In some embodiments, the proximal portion of the catheter is defined by a therapeutic compound inlet port on a back end hub, which is attached proximally. In the exemplary embodiment the back end hub is attached to a control box connector, which is described in greater detail below.

In an exemplary embodiment, the central lumen is configured to receive a guidewire (not shown) having a diameter of between approximately 0.010 inch (0.01 inch±0.005 inch) to approximately 0.012 inch (0.012 inch±0.005 inch). In an exemplary embodiment, the inner core is formed from polymide or a similar material, which can optionally be braided to increase the flexibility of the tubular body 1105.

Referring now to an exemplary embodiment illustrated in FIG. 4B, the distal end of the tubular body includes an ultrasound radiating member 1110. In the illustrated embodiment, the ultrasound radiating member 1110 comprises an ultrasonic transducer, which converts, for example, electrical energy into ultrasonic energy.

An inner core extends through the ultrasound radiating member, which is positioned over the inner core. The ultrasound radiating member can be secured to the inner core in a suitable manner, such as with an adhesive. Extending the core through the member advantageously provides enhanced cooling of the ultrasound radiating member. A therapeutic compound can be injected through a central lumen, thereby providing a heat sink for heat generated by the ultrasound radiating member. The therapeutic compound can enhance the effect of the ultrasound on the nerves surrounding the blood vessel.

Suitable operating frequencies for the ultrasound radiating member include, but are not limited to, from about 20 kHz (20 kHz±2 kHz) to less than about 20 MHz (20 MHz±2 MHz). In one embodiment, the frequency is between 500 kHz and about 20 MHz (20 MHz±2 MHz), and in another embodiment the frequency is between about 1 MHz (1 MHz±0.1 MHz) and about 3 MHz (3 MHz±0.3 MHz). In yet another embodiment, the ultrasonic energy has a frequency of about 3 MHz (3 MHz±0.3 MHz).

In some embodiments, the unfocused ultrasound radiates circumferentially around the blood vessel through the blood and through the blood vessel wall to affect the nerves outside the blood vessel. The nerves may be affected by vibratory energy, heat, mechanical energy, or all or some of these combined. Radiofrequency energy may also be applied simultaneously with any one, some, or all, of these energies as well. In one embodiment, a balloon is applied to the wall of the renal artery blood vessel, and then ultrasound, radiofrequency, light, heat, pharmaceuticals, combination of these, or all of these, may be applied to and through the wall of the blood vessel. The balloon may be crescent shaped or other shape to allow for blood to flow in the center of the balloon and the tissue to conform to the catheter.

In another embodiment, light is applied through the vessel from within the blood vessel. Infrared, red, blue, and near infrared can all be utilized to affect the function of nerves surrounding blood vessels. For example, a light source is introduced into the renal artery or renal vein 1105, 1106 and the light transmitted to the region surrounding the blood vessels. In a preferred embodiment, a photosensitizing agent is utilized to hasten the inhibition or destruction of the nerve bundles with this technique. Photosensitizing agents can be applied systemically to infiltrate the region around the blood vessels. Light is then applied from inside the vessel to the region of the nerves outside the vessel. For example, the light source is placed inside the renal vein and then light is transmitted through the vein wall to the adventitial region around the wall activating the photosensitizer and injuring or inhibiting the nerves in the adventitia through an apoptosis pathway. The light source may provide light that is visible, or light that is non-visible. In another embodiment, the light is applied to the region without photosensitizer. The light generates heat in the region through absorption of the light. Wavelengths such as those in the red, near-infrared, and infrared region are absorbed by the tissues around the artery and leads to destruction of the nerves in the region.

In one embodiment, a string of light emitting diodes (LEDs) is fed into the blood vessel and the vessel illuminated with light from inside the vessel. Lights that are near infrared and infrared have good penetration in blood and through tissues and can be utilized to heat or activate pharmaceuticals in the region surrounding the blood vessel leading to the kidney. These light frequency devices and energies can be utilized to visualize the inside and/or outside of the blood vessel. Intravascular OCT might be utilized to visualize damage to the nerves surrounding the blood vessels.

The therapies in FIGS. 4A-B can be delivered on an acute basis such as for example in an ICU or critical care setting. In such a case, the therapy would be acute and intermittent, with the source outside the patient and the catheter within the patient as shown in FIGS. 4a-b. The therapy can be utilized during times of stress for the patient such that the sympathetic system is slowed down. After the intensive care admission is nearing a close, the catheter and unit can be removed from the patient. In one embodiment, a method is described in which a catheter is placed within a patient to deliver energy to a region of the body sufficient to partially or fully inhibit an autonomic nerve complex during a state of profound sympathetic activation such as shock, sepsis, myocardial infarction, pancreatitis, post-surgical. After the acute phase of implantation during which the sympathetic system is modulated, the device is removed entirely.

FIG. 5A depicts a drug delivery catheter 1500 to deliver phototherapeutic agents or other agents to the region surrounding the renal artery. Agents 1510 might include various agents to create a cloud of heat or cold around the vessel. For example, the heat might be created by steam released through the drug delivery catheter or a balloon to the region of the renal nerves. Carbon Dioxide in high concentration is another agent which can be utilized to anesthetize or inactivate the nerves surrounding the blood vessels leading to the kidney. Neurotoxic agents (e.g. alcohol or phenol), fibrotic agents, and surfactant agents might also be introduced into the region surrounding the blood vessel to inhibit the nerves surrounding the blood vessel. Spines 1505 on the delivery balloon are utilized to gain access to the region surrounding the renal blood vessels. Spines 1505 also may facilitate energy sources such as light or electrical current in inhibiting the nerves surrounding the vessels. In a preferred embodiment, spines 1505 emit a gas such as water vapor or carbon dioxide under pressure and into the adventitia of the blood vessel. The spines may be activated with air pressure, fluid pressure, or shape memory. In the case where the spines are comprised of shape memory, nitinol or shape memory plastics might be incorporated into the device so that the spines open when a sheath is pulled back from over the distal tip of the catheter. In a preferred embodiment, work has shown that spines smaller than approximately 500 micron in diameter have minimal to no effect on the blood vessel intima or adventitia or surrounding subcutaneous and that agents can be introduced into the walls of the blood vessel with impunity. Therefore, in one embodiment, a catheter is introduced into a blood vessel such as the renal artery or vein, and a sheath removed from over the device, or pressure applied, activating the spines to penetrate through the vessel intima. Phototherapeutic, gaseous, vapor, neurotoxic, or ultrasound enhancing agents are introduced into the wall or adventitia of the blood vessel. External energy, including ultrasound or electromagnetic waves, is applied from outside the patient in some embodiments and in others, agents themselves create the desired effect. In one preferred embodiment, water vapor (steam) is passed through the spines into the adventitia of the blood vessel and into the nerve bundles surrounding the blood vessel to inhibit, ablate, or otherwise stop the nerves from functioning.

FIG. 5B depicts a close up of the catheter 1502 to deliver phototherapeutic and other agents 1510 to the region surrounding the blood vessels. Pressure can be used to expel the agents or the carriers which hold on to the agents as they are pushed through the catheter. Although an expandable distal end is shown, it is possible that the distal end does not expand to deliver the agents to the blood vessel adventitia and pressure is utilized to press the agents into the adventitia of the blood vessel (e.g. with a balloon 1508). Structures 1505 which emanate from the balloon might, in some embodiments, have multiple lumens, and in others, consist of a single lumen. The spines can reside within 1505 the vessel wall or traverse 1507 the wall.

FIG. 6 illustrates an overall schematic of the renal artery, renal vein, the collecting system (ureter, calyces, renal pelvis, etc), and the more distal vessels and collecting system within the renal parenchyma. The individual nerves of the autonomic nervous system typically follow the body vasculature and they are shown in close proximity 3000 to the renal artery as the artery enters the kidney 3100 proper. The hilum of the kidney contains pressure sensors and chemical sensors which influence the inputs to the efferent sympathetic system via afferent nerves traveling from the kidney to the central nervous system and then to the efferent nervous system. Any one or multiple of these structures can influence the function of the kidney. Ablative or non-ablative energy can be applied to and/or from the renal vein, the renal artery, the aorta, ureter, and/or the vena cava, the renal hilum, the renal parenchyma, renal pelvis including the collecting system, the renal medulla, the renal cortex, etc. An example of non-ablative energy may be vibration such as from an unfocused ultrasound source. Another non-ablative energy may be light such as through photodynamic therapy. Another type of non-ablative energy may be electromagnetic energy transmitted through a patient such as with a large coil with current running through it. In this embodiment, vibrational energy from an internal or external source is applied to the chemo- or mechanoreceptors of the kidney or near the kidney to modulation their contribution to signals traveling into the autonomic nervous system. Similar treatments may be applied to the carotid sinus or carotid body region to inhibit or alter the autonomic nervous system. In one embodiment of the current invention, a system is placed at an external position to the patient and energy is delivered to a region of the autonomic nervous system. The region might be nerves leading to viscera such as the kidney, nerves leading to or from the carotid body or sinus, nerves leading to the pulmonary bronchi or blood vessels in the lung. The energy source can be electromagnetic, ionizing radiation, ultrasound, radiofrequency energy, electromagnetic energy, and others which can deliver energy effectively through the skin to the autonomic nerves.

In another embodiment, selective lesions, constrictions or implants 3200 are placed in the calyces of the kidney 3100 to control or impede blood flow to specific regions of the kidney. Such lesions or implants can be placed on the arterial 3010 or venous sides 3220 of the kidney. In some embodiments, the lesions/implants are created so as to selectively block certain portions of the sympathetic nerves within the kidney. The lesions also may be positioned so as to ablate regions of the kidney which produce hormones, such as renin, which can be detrimental to a patient in excess. The implants or constrictions can be placed in the aorta 3210 or the renal vein 3230. The implants can be active implants, generating stimulating energy chronically or multiple ablative or inhibitory doses discretely over time.

In the renal vein 3230, the implants 3220, 3200 might cause an increase in the pressure within the kidney (by allowing blood flow to back up into the kidney and increase the pressure) which will prevent the downward spiral of systolic heart failure described above because the kidney will act as if it is experiencing a high pressure head. That is, once the pressure in the kidney is restored or artificially elevated by increased venous pressure, the relative renal hypotension signaling to retain electrolytes and water will not be present any longer and the kidney will “feel” full and the renal sympathetic stimulation will be turned off. In one embodiment, a stent which creates a stenosis is implanted using a catheter delivery system. In another embodiment, a stricture 3220 is created using heat delivered either externally or internally. Externally delivered heat is delivered via direct heating via a percutaneous procedure (through the skin to the region of the kidney) or transmitted through the skin (e.g. with HIFU focused through the skin). In one embodiment, an implant is placed between girota's fascia and the cortex 3100 of the kidney. The implant can stimulate or inhibit nerves surrounding the renal blood vessels, or even release pharmaceuticals in a drug delivery system on a long term basis. This region is easy to access through the flank of the patient utilizing any of a variety of imaging techniques.

FIG. 7A depicts at least partial ablation of the renal sympathetic nerves 4400 to the kidney using an imaging system such as an MRI machine or CT scanner 4000. The MRI/CT scan can be linked to a focused ultrasound (HIFU) machine to perform the ablations of the sympathetic nerves 4400 around the region of the renal artery 4500. The MRI/CT scan performs the imaging 4010 (FIG. 7B) and transmits data (e.g. three dimensional representations of the regions of interest) to the ultrasound controller which then directs the ultrasound to target the region of interest with low intensity ultrasound (50-1000 mW/cm2), heat (>1000 mW/cm2), cavitation, histotripsy, or a combination of these modalities and/or including introduction of enhancing bioactive agent delivery locally or systemically (sonodynamic therapy). Optionally, a doppler/B-mode ultrasound or other 3D/4D ultrasound is performed and the data pushed to the MRI system to assist with localization of the pathology; alternatively, the ultrasound data are utilized to directly control the direction of the energy being used to target the physiologic processes and CT/MRI is not obtained. Using this imaging and ablation system from a position external to a patient, many regions of the kidney can be treated such as the internal calyces 4350, the cortex 4300, the medulla 4320, the hilum 4330, and the region 4340 close to the aorta. Optionally, an intravascular catheter can be introduced into the patient to augment the procedure with intravascular energy, temperature measurement, acoustic energy detection, ionizing radiation detection, etc. For example, the catheter might be able to deliver radiofrequency energy to the wall of the blood vessel, or the catheter might be heated in response to the magnetic field being applied across the patient. For example, a balloon or other catheter tip with a metallic coating will be heated in the presence of a magnetic field. This heat, typically unwanted in the presence of an intravascular catheter, can be utilized to inhibit, or ablate the nerves leading to the kidney (as an example). The MRI system also has the advantage of being able to measure temperature and/or looking at tissue changes around the blood vessels treated, as described below. Similarly, the intravascular catheter can heat up in response to ultrasound in the case where the catheter contains elements which contain interfaces sensitive to ultrasound energy which result in heat as the ultrasound interacts with the elements.

Further parameters which can be measured include temperature via thermal spectroscopy using MRI or ultrasound thermometry/elastography; thermal imaging is a well-known feature of MRI scanners; the data for thermal spectroscopy exists within the MRI scan and can be extrapolated from the recorded data in real time by comparing regions of interest before and after or during treatment. Temperature data overlaid on the MRI scan enables the operator of the machine to visualize the increase in temperature and therefore the location of the heating to insure that the correct region has indeed been ablated and that excessive energy is not applied to the region. Having temperature data also enables control of the ablation field as far as applying the correct temperature for ablation to the nerves. For example, the temperature over time can be determined and fed back to the operator or in an automated system, to the energy delivery device itself. Furthermore, other spectroscopic parameters can be determined using the MRI scan; parameters such as oxygenation, blood flow, inflammation, or other physiologic and functional parameters. In one embodiment, an alternating magnetic field is used to stimulate and then over-stimulate or inhibit an autonomic nerve (e.g. to or from the kidney).

Elastography is a technique in which the shear waves of the ultrasound beam and reflectance are detected. The tissue characteristics change as the tissue is heated and the tissue properties change. An approximate temperature can be assigned to the tissue based on elastography and the progress of the heating can be monitored.

MRI scanners 4000 generally consist of a magnet and an RF coil. The magnet might be an electromagnet or a permanent magnet. The coil is typically a copper coil which generates a radiofrequency field. Recently, permanent magnets have been utilized to create MRI scanners which are able to be used in almost any setting, for example a private office setting. In addition, super-cooled coils have been developed in which a cryogenic fluid is circulated within or around the copper coil, allowing for higher current and greater sensitivity for imaging. Such configuration is advantageous in that it results in an image with a 0.3 T magnet to have an image quality like that from a 1.5 T magnet. Therefore, one system for treatment includes an MRI machine with a permanent magnet and coils which are supercooled along with a focused ultrasound system to apply heat to a target region within a patient. Office based MRI scanners enable imaging to be performed quickly in the convenience of a physician's office as well as requiring less magnetic force (less than 0.5 Tesla) and as a consequence, less shielding. The lower tesla magnets also provides for special advantages as far as diversity of imaging and resolution of certain features. Importantly, the permanent magnet MRI scanners are open scanners and do not encapsulate the patient during the scan. Low Tesla scanners may have magnets below 0.5 T down to 0.1 T field strength.

In one embodiment, a permanent magnet MRI is utilized to obtain an MRI image of the region of interest 4010. High intensity focused 4100 (FIG. 7C) ultrasound is used to target the region of interest 4600 identified using the MRI. In one embodiment, the MRI is utilized to detect blood flow within one or more blood vessels such as the renal arteries 4700, renal veins, superior mesenteric artery, veins, carotid arteries and veins, aortic arch coronary arteries, veins, to name a subset. In this embodiment, a coil designed specifically for the renal blood vessels may wrap around the backside of the patient, or the flank of the patient. In some embodiments, the coil is a surface coil placed behind the patient and specifically designed to increase the sensitivity of the imaging of the retroperitoneal organs.

Image 4010 is or can be monitored by a health care professional to ensure that the region of interest is being treated and the treatment can be stopped if the assumed region is not being treated. Alternatively, an imaging algorithm can be initiated in which the region of interest is automatically (e.g. through image processing) identified and then subsequent images are compared to the initial demarcated region of interest.

Perhaps, most importantly, with MRI, the region around the renal arteries 4400, veins, renal hilum 4320, ureter 4330, cortex 4300, medulla 4320 can be easily imaged as can any other region such as the eye, brain, prostate, breast, liver, colon, spleen, aorta, hip, knee, spine, venous tree, and pancreas. In particular, vascular regions within these organs may be visualized and targeted with focused ultrasound. The imaging from the MRI can be utilized to precisely focus the ultrasound beam to the region of interest around the renal arteries or elsewhere in the body. With MRI, the actual nerves to be modified or modulated can be directly visualized and targeted with the energy delivered through the body from the ultrasound transducers. One disadvantage of MRI can be the frame acquisition (difficulty in tracking the target) rate as well as the cost of introducing an MRI machine into the treatment paradigm. In these regards, ultrasound imaging offers a much more practical solution. In some embodiments, the advantages of ultrasound and MRI are combined into a single system. In some embodiments, an intravascular catheter is further combined with the two imaging modalities to further enhance the treatment. In one embodiment, the intravascular catheter has a ferromagnetic tip which is moveable or heatable (or both) by the MRI scanner. The tip can be manipulated, manually or by the magnetic field (or both) to apply pressure to the wall of the blood vessel and subsequently heat the wall. In some embodiments, the tip can perform the above function(s) while measuring the temperature of the region around the blood vessel (the nerve region). In other embodiments, another device may be used to measure the temperature.

FIG. 7D depicts a method of treating a region with high intensity focused ultrasound (HIFU). Imaging with an MRI 4520 or ultrasound 4510 (or preferably both) is performed. MRI can be used to directly or indirectly (e.g. using functional MRI or spectroscopy) to visualize the sympathetic nerves. T1 weighted or T2 weighted images can be obtained using the MRI scanner. In addition to anatomic imaging, the MRI scanner can also obtain temperature data 4570 regarding the effectiveness of the ablation zone as well as the degree to which the zone is being heated and which parts of the zones are being heated. Other spectroscopic parameters can be added as well such as blood flow and even nerve activity. Edema, inflammation, and necrosis can be detected as well with MRI. Ultrasound 4510 can be used to add blood flow to the images using Doppler imaging. The spectroscopic data can be augmented by imaging moieties such as particles, imaging agents, or particles coupled to imaging agents which are injected into the patient intravenously, or locally, and proximal to the region of the renal arteries; these imaging moieties may be visualized on MRI, ultrasound, or CT scan. Ultrasound can also be utilized to determine information regarding heating. The reflectance of the ultrasonic waves changes as the temperature of the tissue changes. By comparing the initial images with the subsequent images after heating, the temperature change which occurred after the institution of heating can be determined. Therefore, in one embodiment, information regarding heating at baseline is determined and incorporated into the treatment modeling during the ongoing treatment at time subsequent to t=0.

In one embodiment, the kidneys are detected by a cross-sectional imaging modality such as MRI, ultrasound, or CT scan. The renal arteries and veins are detected within the MRI image utilizing contrast or not utilizing contrast. Next, the imaging data is placed into a three dimensional coordinate system which is linked to one or more ultrasound (e.g. HIFU) transducers 4540 which focus ultrasound onto the region of the renal arteries in the coordinate frame 4530. The linking, or coupling, of the imaging to the therapeutic transducers is accomplished by determining the 3 dimensional position of the target by creating an anatomic model. The transducers are placed in a relative three dimensional coordinate frame as well. For example, the transducers can be placed in the imaging field 4520 during the MRI or CT scan such that the cross-sectional pictures include the transducers. Optionally, the transducers contain motion sensors, such as electromagnetic, optical, inertial, MEMS, and accelerometers, one or more of which allow for the transducer position to be monitored if for example the body moves relative to the transducer or the operator moves relative to the body. With the motion sensors, the position of the transducers can be determined with movement which might occur during the therapy. The updated information can then be fed back to the ultrasound therapy device so as to readjust the position of the therapy.

In one embodiment, a system is described in which the blood flow in the renal artery is detected by detecting the walls of the artery or renal vein or the blood flow in the renal artery or the renal vein. The coordinate reference of the blood vessels is then transmitted to the therapeutic transducer, for example, ultrasound. The therapeutic transducer is directed to the renal blood vessels using the information obtained by imaging. A model 4545 (FIG. 16M for example) of the vessels (including blood flow, movement, etc.) indicates the blood flow of the vessels and the walls of the vessels where the nerves reside. Energy from the transducers 4550 is then applied to the model 4545 of the vessels to head 4560 and treat the nerves around the vessels.

Alternatively, in another embodiment, ultrasound is utilized and the ultrasound image 4510 can be directly correlated to the origin of the imaging transducer. In some embodiments the ultrasound is in two dimensions and in others, the ultrasound is presented in three dimensions. In some embodiments, the ultrasound is presented in a combination of two and three dimensions. For example, a two dimensional transducer may be quickly rotated at a specified speed and the integration of the pictures provides a three dimensional approximation. The therapeutic transducer 4540 in some embodiments is the same as the imaging transducer and therefore the therapeutic transducer is by definition coupled in a coordinate reference 4540 once the imaging transducer coordinates are known. If the therapeutic transducer and the imaging transducer are different devices, then they can be coupled by knowledge of the relative position of the two devices. The region of interest (ROI) is highlighted in a software algorithm; for example, the renal arteries, the calyces, the medullary region, the cortex, the renal hila, the celiac ganglia, the aorta, or any of the veins of the venous system as well. In another embodiment, the adrenal gland, the vessels traveling to the adrenal gland, or the autonomic nerves traveling to the adrenal gland are targeted with focused ultrasound and then either the medulla or the cortex of the adrenal gland or the nerves and arteries leading to the gland are partially or fully ablated with ultrasonic energy.

The targeting region or focus of the ultrasound is the point of maximal intensity. In some embodiments, targeting focus is placed in the center of the artery such that the walls on either side receive equivalent amounts of energy or power and can be heated more evenly than if one wall of the blood vessel is targeted. In some embodiments in which a blood vessel is targeted, the blood vessel being an artery and the artery having a closely surrounding vein (e.g. the renal artery/vein pedicle), the center of the focus might be placed at the boundary of the vein and the artery.

Once the transducers are energized 4550 after the region is targeted, the tissue is heated 4560 and a technique such as MRI thermography 4570 or ultrasound thermography is utilized to determine the tissue temperature. During the assessment of temperature, the anatomic data from the MRI scan or the Doppler ultrasound is then referenced to ensure the proper degree of positioning and the degree of energy transduction is again further assessed by the modeling algorithm 4545 to set the parameters for the energy transducers 4550. If there is movement of the target, the transducers may have to be turned off and the patient repositioned. Alternatively, the transducers can be redirected to a different position within the coordinate reference frame.

Ablation can also be augmented using agents such as magnetic nanoparticles or liposomal nanoparticles which are responsive to a radiofrequency field generated by a magnet. These particles can be selectively heated by the magnetic field. The particles can also be enhanced such that they will target specific organs and tissues using targeting moieties such as antibodies, peptides, etc. In addition to the delivery of heat, the particles can be activated to deliver drugs, bioactive agents, or imaging agents at the region at which action is desired (e.g. the renal artery). The particles can be introduced via an intravenous route, a subcutaneous route, a direct injection route through the blood vessel, or a percutaneous route. As an example, magnetic nanoparticles or microparticles respond to a magnetic field (e.g. by a MRI device) by generating heat in a local region around them. Similarly, liposomal particles might have a metallic particle within such that the magnetic particle heats up the region around the liposome but the liposome allows accurate targeting and biocompatibility.

The addition of Doppler ultrasound 4510 may be provided as well. The renal arteries are (if renal arteries or regions surrounding the arteries are the target) placed in a 3D coordinate reference frame 4530 using a software algorithm with or without the help of fiducial markers. Data is supplied to ultrasound transducers 4540 from a heat modeling algorithm 4545 and the transducers are energized with the appropriate phase and power to heat the region of the renal artery to between 40° C. and 90° C. within a time span of several minutes. The position within the 3D coordinate reference is also integrated into the treatment algorithm so that the ultrasound transducers can be moved into the appropriate position. The ultrasound transducers may have frequencies below 1 megahertz (MHz), from 1-20 MHz, or above 30 Mhz, or around 750 kHz, 500 kHz, or 250 kHz. The transducers may be in the form of a phased array, either annular, linear or curved, or the transducers may be mechanically moved so as to focus ultrasound to the target of interest. In addition, MRI (or ultrasound thermography) 4570 can be utilized so as to obtain the actual temperature of the tissue being heated. These data can be further fed into the system to slow down or speed up the process of ablation 4560 via the transducers 4550. For example, in the case where the temperature is not rising as fast as planned, the energy level can be increased. On the other hand, where the temperature is rising faster than originally planned, the energy density can be decreased.

Aside from focused ultrasound, ultrasonic waves can be utilized directly to either heat an area or to activate pharmaceuticals in the region of interest. There are several methodologies to enhance drug delivery using focused ultrasound. For example, particles can release pharmaceuticals when they are heated by the magnetic field. Liposomes can release a payload when they are activated with focused ultrasound. Ultrasound waves have a natural focusing ability if a transducer is placed in the vicinity of the target and the target contains an activateable moiety such as a bioactive drug or material (e.g. a nanoparticle sensitive to acoustic waves). Examples of sonodynamically activated moieties include some porphyrin derivatives.

So as to test the region of interest and the potential physiologic effect of ablation in that region, the region can be partially heated or vibrated with the focused ultrasound to stun or partially ablate the nerves. Next, a physiologic test such as the testing of blood pressure or measuring norepinephrine levels in the blood, kidney, blood vessels leading to or from the kidney, can be performed to ensure that the correct region was indeed targeted for ablation. Patient pain, quality, quantity, and location can also be used to determine if and where therapy has been delivered. Depending on the parameter, additional treatments may be performed.

Clinically, this technique might be called fractionation of therapy which underscores one of the major advantages of the technique to apply external energy versus applying internal energy to the renal arteries. An internal technique requires invasion through the skin and entry into the renal artery lumens which is costly and potentially damaging. Patients will likely not accept multiple treatments, as they are highly invasive and painful. An external technique allows for a less invasive treatment to be applied on multiple occasions, made feasible by the low cost and minimal invasion of the technology described herein.

In another embodiment, a fiducial is utilized to demarcate the region of interest. A fiducial can be intrinsic (e.g. part of the anatomy) or the fiducial can be extrinsic (e.g. placed in position). For example, the fiducial can be an implanted fiducial, an intrinsic fiducial, or device placed in the blood vessels, or a device placed percutaneously through a catheterization or other procedure. The fiducial can also be a bone, such as a rib, or another internal organ, for example, the liver. In one embodiment, the fiducial is a beacon or balloon or balloon with a beacon which is detectable via ultrasound. In another embodiment, the fiducial is a stent implanted in the renal artery, renal vein, vena cava, or aorta. The stent can be periodically heated by the MRI or ultrasound in the case where treatment is needed to be reapplied. In one embodiment, the blood flow in the renal arteries, detected via Doppler or B-mode imaging, is the fiducial and its relative direction is determined via Doppler analysis. Next, the renal arteries, and specifically, the region around the renal arteries are placed into a three dimensional coordinate frame utilizing the internal fiducials. A variant of global positioning system technology can be utilized to track the fiducials within the artery or around the arteries. In this embodiment, a position sensor is placed in the artery or vein through a puncture in the groin. The position of the sensor is monitored as the sensor is placed into the blood vessel and its position in physical space relative to the outside of the patient, relative to the operator and relative to the therapeutic transducer is therefore known. The three dimensional coordinate frame is transmitted to the therapeutic ultrasound transducers and then the transducers and anatomy are coupled to the same coordinate frame. At this point, the HIFU is delivered from the transducers, calculating the position of the transducers based on the position of the target in the reference frame. The fiducial may be active, in which electrical current is transmitted into the fiducial through a catheter or through induction of energy transmitted through the skin. The energy transmitted from the catheter back through the skin or down the catheter and out of the patient may be utilized to indicate the coordinates of treatment target(s) so that the externally directed energy may be applied at the correct location(s). The internal fiducials may be utilized to track motion of the region to which energy is being delivered. In some embodiments, there are multiple fiducials within the vessels being treated. For example, several fiducials are placed inside the renal artery so that the direction and/or shape of the vessel can be determined. Such information is important in the case of tortuosity of the blood vessel. Such redundancy can also be used to decrease the error and increase the accuracy of the targeting and tracking algorithms.

In one embodiment, a virtual fiducial is created via an imaging system. For example, in the case of a blood vessel such as the renal artery, an image of the blood vessel using B-mode ultrasound can be obtained which correlates to the blood vessel being viewed in direct cross section (1705; FIG. 17F). When the vessel is viewed in this type of view, the center of the vessel can be aligned with the center 1700 of an ultrasound array (e.g. HIFU array 1600) and the transducers can be focused and applied to the vessel, applying heat lesions 1680 to regions around the vessel 1705. With different positions of the transducers 1610 along a circumference or hemisphere 1650, varying focal points can be created 1620, 1630, 1640. The directionality of the transducers allows for a lesion(s) 1620, 1630, 1640 which run lengthwise along the vessel 1700. Thus, a longitudinal lesion 1620-1640 can be produced along the artery to insure maximal inhibition of nerve function. In some embodiments, the center of the therapeutic ultrasound transducer is off center relative to the center of the vessel so that the energy is applied across the vessel wall at an angle, oblique to the vessel. The transducer 1600 can also be aspheric in which the focus of the transducer is off center with respect to its central axis.

In this method of treatment, an artery such as a renal artery is viewed in cross-section or close to a cross-section under ultrasound guidance. In this position, the blood vessel is substantially parallel to the axis of the spherical transducer so as to facilitate lesion production. The setup of the ultrasound transducers 1600 has previously been calibrated to create multiple focal lesions 1620, 1630, 1640 along the artery if the artery is in cross-section 1680.

In one embodiment, the fiducial is an intravascular fiducial such as a balloon or a hermetically sealed transmitting device. The balloon is detectable via radiotransmitter within the balloon which is detectable by the external therapeutic transducers. The balloon can have three transducers, each capable of relaying its position so that the balloon can be placed in a three dimensional coordinate reference. Once the balloon is placed into the same coordinate frame as the external transducers using the transmitting beacon, the energy transducing devices can deliver energy (e.g. focused ultrasound) to the blood vessel (e.g. the renal arteries) or the region surrounding the blood vessels (e.g. the renal nerves). The balloon and transmitters also enable the ability to definitively track the vasculature in the case of movement (e.g. the renal arteries). In another embodiment, the balloon measures temperature or is a conduit for coolant applied during the heating of the artery or nerves. Multiple transducers might be set up outside the patient to detect the position of the internal fiducial from different directions (rather than three internal transducers, in this embodiment, there are three external transducers detecting the position of a single or multiple internal fiducials). Again, such redundancy in targeting position is beneficial because the exact position of the internal fiducial may be determined correctly. In another embodiment, multiple internal fiducials are placed inside the patient, in particular, within a blood vessel to determine the three dimensional orientation of the blood vessel.

Delivery of therapeutic ultrasound energy to the tissue inside the body is accomplished via the ultrasound transducers which are directed to deliver the energy to the target in the coordinate frame.

Once the target is placed in the coordinate frame and the energy delivery is begun, it is important to maintain targeting of the position, particularly when the target is a small region such as the sympathetic nerves. To this end, the position of the region of ablation is compared to its baseline position, both in a three dimensional coordinate reference frame. The ongoing positional monitoring and information is fed into an algorithm which determines the new targeting direction of the energy waves toward the target. In one embodiment, if the position is too far from the original position (e.g. the patient moves), then the energy delivery is stopped and the patient repositioned. If the position is not too far from the original position, then the energy transducers can be repositioned either mechanically (e.g. through physical movement) or electrically via phased array (e.g. by changing the relative phase of the waves emanating from the transducers). In another embodiment, multiple transducers are placed on the patient in different positions and each is turned on or off to result in the necessary energy delivery. With a multitude of transducers placed on the patient, a greater territory can be covered with the therapeutic ultrasound. The therapeutic positions can also serve as imaging positions for intrinsic and/or extrinsic fiducials.

In addition to heat delivery, ultrasound can be utilized to deliver cavitating energy which may enable drug delivery at certain frequencies. Cavitating energy can also lead to ablation of tissue at the area of the focus. A systemic dose of a drug can be delivered to the region of interest and the region targeted with the cavitating or other forms of ultrasonic energy. Other types of therapeutic delivery modalities include ultrasound sensitive bubbles or radiation sensitive nanoparticles, all of which enhance the effect of the energy at the target of interest. Therefore in one method, an ultrasonically sensitive bioactive material is administered to a patient, and focused ultrasound is applied through the skin of the patient to the region of the blood vessels leading to the kidney. The effect of the ultrasound on the region around the blood vessels is to release the bioactive material or otherwise heat the region surrounding the blood vessel. The ultrasonically sensitive bioactive material may be placed in a vessel, in which cases, ultrasound can be applied through the wall of the blood vessel to activate the material.

FIG. 7E depicts the anatomy of the region 4600, the kidneys 4620, renal arteries 4630, and bony structures 4610, 4640 as viewed from behind a human patient. FIG. 7E depicts the real world placement of the renal arteries into coordinate frame as outlined in FIG. 7D. Cross sectional CT scans from actual human patients were integrated to create a three-dimensional representation of the renal artery, kidney, and mid-torso region. Plane 4623 is a plane parallel to the transverse processes and angle 4607 is the angle one has to look up (toward the head of the patient) in order to “see” the renal artery under the rib. Such real world imaging and modeling allows for an optimal system to be developed so as to maximize efficacy and minimize risk of the treatment. Therefore with these parameters to consider, a system to treat the nerves surrounding the renal arteries is devised in which a transducer is positionable (e.g., to adjust a line of sight) with a negative angle with respect to a line connecting the spinal processes. Multiple transducers may be utilized to allow variations in the positioning associated with variations in anatomy or during respiratory motion, wherein the anatomy may be tracked during treatment.

FIG. 7F depicts an image 4642 of the region of the renal arteries and kidney 4605 using ultrasound. The renal hilum containing the arteries and vein 4640 can be visualized using this imaging modality. This image is typical when looking at the kidney and renal artery from the direction and angle depicted in FIG. 7E. Importantly, at the angle 4607 in 7E, there is no rib in the ultrasound path and there no other important structures in the path either.

An ultrasound imaging trial was then performed to detect the available windows to deliver therapeutic ultrasound to the region of the renal arteries 4630 from the posterior region of the patient. It was discovered that the window depicted by arrow 4600 and depicted by arrow 4605 in the cross-sectional ultrasound image from ultrasound (FIG. 7F) provided optimal windows to visualize the anatomy of interest (renal pedicle).

FIG. 7G contains some of the important data from the trial 4700, the data in the “standard (supine) position 4730.” These data 4720 can be used to determine the configuration of the clinical HIFU system to deliver ultrasound to the renal hilum. The renal artery 4635 was determined to be 7-17 cm from the skin in the patients on average. The flank to posterior approach was noted to be optimum to image the renal artery, typically through the parenchyma of the kidney as shown in FIG. 7F4605. The hilum 4640 of the kidney is approximately 4-8 cm from the ultrasound transducer and the angle of approach 4637 (4607 in FIG. 7E) relative to an axis defined by the line connecting the two spinous processes and perpendicular to the spine . . . is approximately −10 to −48 degrees; the negative direction is a tilt around this axis such that the transducer is directed upward toward the head of the patient. Zero degrees is when the face of the transducer is parallel with the patient. It was also noted that the flank approach through the kidney was the safest approach in that it represents the smallest chances of applying ultrasound to other organs such as bowel.

Therefore, with these data, a system algorithm for treatment may been devised: b-mode ultrasound is utilized to visualize the kidney in cross-section; doppler ultrasound is utilized to identify the pedicle 4640 traveling to the kidney with the renal artery as the identifying anatomical structure via Doppler ultrasound; the distance to the pedical is determined via the b-mode imaging. With the kidney inside the b-mode image, safety can be attained as the kidney has been determined to be an excellent heat sink and absorber (that is HIFU has little effect on the kidney) of HIFU (see in-vivo data below); the distance is fed into the processing algorithm and the HIFU transducer is fed the position data of the HIFU transducer. Furthermore, small piezoelectric crystals may be located at (e.g., along) the therapeutic ultrasound transducer, and may be utilized to determine a safe path between a source of ultrasound from the crystal at the ultrasound transducer and the target blood vessel. An echo may be sent from the crystal to the target and the time for a return signal may be determined. With the information about the return signal (e.g. distance to target, speed of return), the safety of the path may be determined. If bowel with air inside (for example) were in the path, the return signal would deviate from an expected signal, and the transducer can then be repositioned.

Similarly, if bone (e.g. rib) is in the path of the ultrasound beam, the expected return signal will significantly deviate from the expected return time, thereby indicating that the path cannot be utilized. In some embodiments, the therapeutic ultrasound frequency may be lowered below 1 MHz, which enables the energy to travel through bone with minimal refraction of the ultrasound wave. For example, frequencies as low as 100 kilohertz, 200 kilohertz, or 300 kilohertz may be utilized in some embodiments.

Upon further experimentation, it was discovered that by positioning the patient in the prone position (backside up, abdomen down), the structures under study 4750 . . . that is, the renal arteries 4770 and 4780, the kidney hilum were even closer to the skin and the respiratory motion of the artery and kidney was markedly decreased. FIG. 7H depicts these results 4750, 4760 showing the renal artery 4770 at 6-10 cm and the angle of approach 4790 relative to the spine 4607 shallower at −5 to −20 degrees. Similar results were obtained in the case where the patient remained flat and the legs were propped up using a wedge or bump under them.

Therefore, with these clinical data, in one embodiment, a method of treatment 4800 (FIG. 7I) of the renal nerves in a patient has been devised: 1) identify the rib 4810 and iliac crest 4840 of a patient on the left and right flank of the patient 4810; 2) identify the left or right sided kidney with ultrasound 4820; 3) identify the hilum of the kidney and the extent the renal hilum is visible along surface of patient 4820 using an imaging technology; 4) identify the blood vessels leading to the kidney from one or more angles, extracting the extent of visibility 4860 along the surface area of the patient's back; 5) determine the distance to the one or more of the renal artery, renal vein, kidney, and the renal hilum 4850; 6) optionally, position patient in the prone position with a substantive positioning device underneath the back of the patient or overtop the abdomen of the patient 4830, to optimize visibility; 7) optionally determine, through modeling, the required power to obtain a therapeutic dose at the renal hilum and region around the renal blood vessels; 8) apply therapeutic energy to renal blood vessels; 9) optionally track the region of the blood vessels to ensure the continued delivery of energy to the region as planned in the modeling; 10) optionally, turning off delivery of energy in the case the focus of the energy is outside of the planned region; 11) optionally, adapting the system through movement of the therapeutic and imaging ultrasound transducers so as to orient the ultrasound applicators in relation to the vessel target; 12) optionally placing a fiducial in one or more blood vessels to further enhance the device's ability to localize and track the vessel; 13) determining an algorithm for treatment based on one or more of: the distance to the vessel, the thickness of the skin, the thickness of the muscle, and the thickness of the kidney through which the ultrasound traverses; 14) applying the therapeutic ultrasound with pulses in less than 10 s to ramp up and apply at least 100 W/cm²for at least one second; 15) optionally, directing the therapeutic transducer at an angle anywhere from −5 to −25 degrees (i.e. pointing upward toward the cephalic region) relative to a line connecting the spinous process.

In another embodiment, FIG. 7J, a clinical algorithm 4900 is depicted in which a position of a blood vessel is determined 4910. For example, the blood vessel may be adjacent a nerve region of interest (e.g. renal artery and nerve, aorta and sympathetic nerves, cerebral arteries and nerves, carotid artery and nerves). A test dose of energy is applied to the threshold of patient sensation 4920. In the case of a renal nerve, the sensation threshold might be a renal colic type of sensation. At the point of sensation 4920, the dose can be lowered and cooled and then an additional dose can be applied at a level just below the sensation threshold. Such a sequence 4900 can be repeated 4940 many times over until the desired effect is achieved. Intermittent off time allows for cooling 4930 of the region. In FIG. 7K, a transducer 4950 is depicted with both diagnostic and therapeutic ability. Wave 4960 is a diagnostic wave which in this example interferes with bone 4963 (rib). In some embodiments, the therapeutic wave which would otherwise emanate from this region of the transducer is switched off and therapeutic waves are not generated. On the other side of the transducer, waves 4956 do indeed allow a clear path to the renal blood vessels 4954 and indeed a therapeutic beam is permitted from this region. The diagnostic energy 4958, 4960 may be ultrasonic energy, radiofrequency energy, X-ray energy, or optical energy. For example, MRI, ultrasound, CT scan, or acoustic time of flight technology might be utilized to determine whether or not a clear path to the renal hilum exists.

In summary, in one technique, a diagnostic test energy is delivered through the skin to the region of the renal blood vessels. Next, an assessment of the visibility of the renal hilum in terms of distance and clearance is made and therapeutic transducers are switched on or off based on clearance to the renal hilum from a path through the skin. Such a technique may continue throughout treatment or prior to treatment. For example, parameters such as movement, distance, three dimensional coordinates, etc. may be tracked during therapy and treatment.

Combining the above data, FIG. 7L depicts a generalized system to inhibit nerves which surround a blood vessel 4975. In a first step, an image of the vessel is produced 4964; next a length of the vessel is scanned 4966; following this step, a direction of the vessel is determined in three dimensional space 4968 and delivery of a heat cloud 4970 is performed circumferentially around the vessel in which the heat cloud is produced to at least cover a region 5 mm from the vessel wall and including the vessel wall in a radial direction and over a length of at least 5 mm. The cloud is a region of diffused heat without focal hot spots. The heat diffuses from the region and can be generated from inside the vessel or outside the vessel. The vessel itself is protected by convection and removal of heat from the vessel via the natural blood flow or through the addition of an additional convective device in or near the vessel.

The heat cloud can be generated by high intensity ultrasound (see modeling and data below), radiofrequency energy, and/or optical energy. For example, infrared energy can be delivered through the blood vessel wall to heat the region surrounding the blood vessel. The heating effect can be detected through MRI thermometry, infrared thermometry, laser thermometry, etc. The infrared light may be applied alone or in combination with phototherapeutic agents.

In some embodiments, a heat cloud is not generated but a cloud to inhibit or ablate nerves in the region may be provided. Such cloud may be gas (e.g. carbon dioxide), liquid (hot water), phototherapeutic agents, and other toxins such as ethanol, phenol, and neurotoxins.

In contrast to devices which deliver highly focused heat to the wall and rely on conduction or current fall from the vessel wall, a heat cloud or generalized cloud presents a potentially safer option in which the nerve ablating components are diffused around the vessel.

FIG. 7M depicts an example of delivering a heat cloud 4974 to a blood vessel from outside the patient 4972. The vessel is placed in a three dimensional coordinate reference. The vessel is targeted during treatment. The cloud surrounds the vessels and the entire hilum leading to the kidney 4976.

FIG. 7N shows a depiction of the nerves 4982 leading to the kidney 4984. This picture is from an actual dissection of the vessels from a human cadaver. As can be seen, the nerves 4982 surround the blood vessels leading to the kidney 4984. The heat cloud 4980 is shown surrounding the nerves 4982 leading to the kidney 4984. Importantly, limitation of previous catheter based approaches was that the heat cloud could not be generated around the vessels from a location inside the vessels. This heat cloud effectively allows for the target region to be overscanned during the treatment.

FIG. 7O depicts a cross section of the cloud 4984 surrounding the nerves 4986 and vessels 4988. It can be seen 4985 that a focal method to heat the nerves through the vessel wall (for example, through focused radiofrequency energy 4983) might be difficult to affect a large portion of the nerves because the nerves are so diffusely presented in the region 4984 in some cases. While radiofrequency energy might heat nerves in a region of a few mm³, focused ultrasound might treat a region as large as 2 cm³, as determined by numerical modeling shown below. Therefore, in this embodiment, heat is applied diffusely to the region surrounding the blood vessel in the form of a cloud 4984. Such “cloud” treatment is correlated with the Quality factor described below. For example, the lower the quality factor, the larger and more diffuse the cloud becomes. When the quality factor is 100%, or 1.0, the cloud is a series of discrete points of heat; when the quality factor is about 90% (e.g., 90%±10%) the cloud is diffused around the vessels as shown in FIG. 7O. Such a heat cloud is optimal to treat a diffusely defined region of nerves 4986 such as shown in FIG. 7O. Therefore in one embodiment, the quality factor may be determined to be anywhere between 70 and 90 percent (the percentage of time the HIFU is within the target region versus outside the target region). Within this range of quality factor, a cloud of heat as opposed to individual points is created around the blood vessel and at the region of the nerves. In other embodiments, the quality factor may be about 50& (e.g., 50%±10%). In still further embodiments, the quality factor may be anywhere from 50% to 90%.

FIG. 7P depicts simulation results 4990 for modeling heating to a blood vessel (for example, a renal artery) with focused ultrasound during movement. The simulation applies to ultrasound generated within the artery or generated external to the patient and importantly, considers random movement within 1 mm 4991 around the proposed treatment zone. FIG. 7Q depicts the proposed treatment paradigm accounting for motion; in this case the motion has been reduced to 0 mm 4992 by a closed loop mechanism for tracking motion and directing the ultrasound beam to account for the movement. The mechanisms and device to account for motion are described in detail below.

As can be seen in the simulation, limiting motion from 1 mm in a random direction to close to 0 mm increases the power and temperature within the tissue 4994. Therefore, in one embodiment, a system with multiple transducers is utilized to treat a region surrounding a blood vessel, wherein treatment planning is considered and movement parameters are incorporated into the treatment. In some embodiments, 1 mm is the assumed movement. In other embodiments, 2 mm is the assumed movement. These movements are 1 or 2 mm in random directions in the 1 or 2 mm volume. In some embodiments, the movement is directly tracked using ultrasound, mechanical sensors, accelerometers, intravascular catheters, or other devices. In one embodiment, a treatment is delivered in which motion is tracked, and when the degree of motion is high, the dose or time of treatment is lengthened. When the degree of motion is low, the dose is lowered. These adjustments may also be performed in real time throughout the treatment.

FIG. 7R depicts an alternative approach 3300 to guidance of a catheter within a patient. Patches 3310 may be individual receivers which receive signals from the catheter 3320 inside the patient. The receivers are single or multiple channel piezoelectric receivers in a configuration which can be easily placed in positions anywhere on the skin of the patient. These patches allow the coordinate reference of the catheter tip to be determined inside the patient and thus related to a coordinate reference outside the patient. The patches 3310, in one embodiment, are receivers which receive an acoustic time of flight signal from the catheter 80. With the catheter related to the patches in the external coordinate reference, it can be advanced into the treatment region by linking the patches to the external coordinate reference. For example, if the patches were related to a cross-sectional imaging device such as a CT scan, the catheter could then be tracked in the CT scan. In one method of use therefore, a catheter is advanced in a patient, the catheter providing signals to patch locaters on the outside of the patient, the external patch locators are then related to the same positions in a three dimensional volume from cross sectional imaging such as CT or MRI. The configuration of the piezoelectric locators is similar to the transducer shown above except that the locators are spread out to different positions about the patient and therefore pick up a wider three dimensional volume.

In FIG. 7S, the method to advance the catheter without external real time guidance (e.g. requiring fluoroscopy) 3350. In one embodiment, a cross sectional imaging technique 3360 is used (e.g. CT scan, MR angiogram) to obtain an image of a patient with respect to external patient markers 3370 (e.g. pelvis, nose, clavicle) or artificial markers (patches 3310 shown in FIG. 7P). With these data, the catheter is advanced into the patient 3390 and then coupled to the cross sectional imaging which allows external markers to correlate with internal images from the cross-sectional imaging. The catheter can then be advanced 3395 into area of interest and therapy performed 3380.

FIG. 7T depicts the pre-procedure process 3400 in which a patient 3430 undergoing a Cat Scan (CT scan) 3420 with external patches 3440 to link the internal images of the patient to the patches 3440.

Catheter (FIG. 7U) 3470 has an effector 3450 on its tip which can help direct the catheter shaft 3460 to a position within the patient by coupling its coordinates to the coordinate reference of the patches on the patient.

FIG. 7V depicts the tip of the catheter 3470 where the communication element 3465 resides. The communication element allows the catheter tip to be placed into a three dimensional coordinate reference and linked to the external patches 3440 on the patient 3430. Once the catheter is placed in the patient, the catheter can be linked to the CT scan image and the catheter can be directed within the patient based on its relationship to the patches. In this case, fluoroscopy would not be needed and all the movement can be directed based on virtual imaging. The catheter is similar if not identical to the other catheters described herein in which a piezoelectric or other locating beacon is placed at the catheter tip and utilized to determine catheter position within the patient.

FIG. 8A depicts a percutaneous procedure and device 5010 in which the region around the renal artery is directly approached through the skin from an external position. A combination of imaging and application of energy (e.g. ablation) may be performed

to ablate the region around the renal artery to treat hypertension, end stage renal disease, diabetes, sleep apnea, and/or heart failure. Probe 5010 is positioned through the skin and in proximity to the kidney 5030. The probe may include sensors at its tip 5020 which detect heat or temperature or may enable augmentation of the therapeutic energy delivery. One or more imaging devices (e.g., CT device, ultrasound device, MRI device) may be utilized to ensure a clear path for the probe to reach the region of the renal hilum. These devices may be utilized to detect the temperature of the ablation region, and provide feedback to the operator as to the quality of the ablation of the renal artery region through the modeling. Ablative, ionizing energy, heat, or light may be applied to the region to inhibit the sympathetic nerves around the renal artery using the probe 5010. Ultrasound, radiofrequency, microwave, direct heating elements, and balloons with heat or energy sources may be applied to the region of the sympathetic nerves. Imaging may be included on the probe or performed separately while the probe is being applied to the region of the renal blood vessels.

In one embodiment, the percutaneous procedure in FIG. 8A is performed under MRI, CT, or ultrasound guidance to obtain localization or information about the degree of heat being applied. In one embodiment, ultrasound is applied but at a sub-ablative dose. That is, the energy level is enough to damage or inhibit the nerves but the temperature is such that the nerves are not ablated but paralyzed or partially inhibited by the energy. A particularly preferred embodiment would be to perform the procedure under guidance from an MRI scanner because the region being heated can be determined anatomically in real time as well via temperature maps. As described above, the images after heating can be compared to those at baseline and the signals are compared at the different temperatures.

In one embodiment, selective regions of the kidney are ablated through the percutaneous access route; for example, regions which secrete hormones which are detrimental to a patient or to the kidneys or other organs. Using energy applied externally to the patient through the skin and from different angles affords the ability to target any region in or on the kidney or along the renal nerves or at the region of the adrenal gland, aorta, or sympathetic chain. This greater breadth in the number of regions to be targeted is enabled by the combination of external imaging and external delivery of the energy from a multitude of angles through the skin of the patient and to the target. The renal nerves can be targeted at their takeoff from the aorta onto the renal artery, at their synapses at the celiac ganglia, or at their bifurcation point along the renal artery.

In a further embodiment, probe 5010 can be utilized to detect temperature or motion of the region while the ultrasound transducers are applying the energy to the region. A motion sensor, position beacon, or accelerometer can be used to provide feedback for the HIFU transducers. In addition, an optional temperature or imaging modality may be placed on the probe 5010. The probe 5010 can also be used to locate the position within the laparoscopic field for the ablations to be performed. The dose delivered by this probe is approximately the same as that delivered through the devices placed external to the patient.

In FIG. 8B, intravascular devices 5050, 5055 are depicted which apply energy to the region around the renal arteries 5065 from within the renal arteries. The intravascular devices can be utilized to apply radiofrequency, ionizing radiation, and/or ultrasound (either focused or unfocused) energy to the renal artery and surrounding regions 5060. MRI or ultrasound or direct thermometry can be further utilized to detect the region where the heat is being applied while the intravascular catheter is in place.

In one embodiment, devices 5050, 5055 (FIG. 8B) apply ultrasound energy which inhibits nerve function not by heating, but by mechanisms such as periodic pressure changes, radiation pressure, streaming or flow in viscous media, and pressures associated with cavitation, defined as the formation of holes in liquid media. Heat can selectively be added to these energies but not to create a temperature which ablates the nerves, thereby facilitating the mechanism of vibration and pressure. In this embodiment, the ultrasound is not focused but radiates outward from the source to essentially create a cylinder of ultrasonic waves that intersect with the wall of the blood vessel. This pattern of ultrasound may lead to a circumferential ablation zone 5065 shown in FIG. 8B. The circumferential ablation zone has been shown in the work below to lead to an adequate decrease in the functioning of the sympathetic nerves to the kidney. An interfacial material between the ultrasound transducer and the wall of the artery may be provided such that the ultrasound is efficiently transduced through the arterial wall to the region of the nerves around the artery. In another embodiment, the ultrasound directly enters the blood and propagates through the blood vessel wall to affect the nerves. In some embodiments, cooling is provided around the ultrasound catheter which protects the inside of the vessel and/or the ultrasound generating element yet allows the ultrasound to penetrate through the wall to the regions outside the artery. Such ultrasound may be focused or unfocused. For example, in some embodiments, the ultrasound may not be HIFU, but low intensity ultrasound which is unfocused. A stabilization method for the ultrasound probe is also included in such a procedure. The stabilization method might include a stabilizing component added to the probe and may include a range finding element component of the ultrasound so that the operator knows where the ultrasound energy is being applied from outside the wall of the blood vessel. The energy for effective ablation or inhibition of the nerves is in the range of 10 W/cm2 to 500 W/cm2. In some embodiments, this circumferential ultrasound is combined with drug delivery to the nerves through the wall of the blood vessel.

In another embodiment, an ultrasound probe is applied directly to the wall of the blood vessel, utilizing heat and/or vibration to inhibit the nerves surrounding the blood vessel. In this embodiment, the temperature at the wall of the blood vessel can be measured directly at the catheter tip through laser thermometry or a thermistor. Alternatively, MRI or infrared thermometry may be used as well during the application of the ultrasound. Similarly, the ultrasound may be utilized in combination with drug delivery to apply pharmaceuticals to the walls or through the walls of the blood vessel.

Imaging can be performed externally or internally in this embodiment in which a catheter is placed inside the renal arteries. For example, external imaging with MRI or Ultrasound may be utilized to visualize changes during the ultrasound modulation of the nerve bundles. Indeed, these imaging modalities may be utilized for the application of any type of energy within the wall of the artery. For example, radiofrequency delivery of energy through the wall of the renal artery may be monitored through similar techniques. Thus the monitoring of the procedural success of the technique is independent of the technique in most cases. In one method, a radiofrequency catheter is applied to the wall of the blood vessel and the temperature of the region around the blood vessel is measured. In another embodiment, heated water vapor is applied to the region of the blood vessel. In another embodiment, MRI induced heating of a metallic tipped catheter is detected using MRI thermometry. In another embodiment, focused ultrasound is detected using MRI thermometry. MRI may be utilized to detect changes in addition to heat. For example, MRI may be utilized to detect edematous changes, or lysis of the nerves during the treatment.

Alternatively, in another embodiment, the devices 5050, 5055 can be utilized to direct externally applied energy (e.g. ultrasound) to the correct place around the artery as the HIFU transducers deliver the energy to the region. For example, the intravascular probe 5050 can be utilized as a homing beacon for the imaging/therapeutic technology utilized for the externally delivered HIFU.

FIG. 8C depicts a percutaneous procedure to inhibit the renal sympathetic nerves. Probe 5010 is utilized to approach the renal hilum 5075 region from posterior and renal artery 5076. With the data presented below, the probe can be armed with HIFU to denervate the region. The data presented below indicates the feasibility of this approach as far as ultrasound enabling denervation of the vessels quickly and easily. In another embodiment, a cloud of heat energy (FIG. 7O) is produced near or around the blood vessel, for example, with warmed gas, with a neurotoxin, with a gas such as carbon dioxide which is known to anesthetize nerves at high concentrations, etc. The warmed gas might be steam or water vapor.

In FIG. 8D, a technique and system 5100 is shown in which ultrasound transmitted 5135 through the wall of a blood vessel 5560 from a catheter 5140 with a piezoelectric crystal 5120 at one end. A detector 5160 is placed outside the skin 5112 of the patient to detect the signal emitted from the piezoelectric. A number of parameters 5170 can be determined/detected with this method including position, temperature, acoustic power, radiation pressure, and cavitation threshold. The detection might be done inside the catheter in some embodiments or at the skin in other embodiments. In one embodiment, for example, the acoustic impedance from the blood vessel to the skin is determined through the detection of the time of flight of the ultrasound waves 5135 from the piezoelectric transducer on the end of the catheter. In another embodiment, structures which might block ultrasound are detected by sending a signal to the external detector 5160 from the internal detector 5120. In another embodiment, the intravascular piezoelectric is combined with external delivery of vibratory energy 5130 to induce damage or inhibit the nerves around the blood vessel. In another embodiment, an ultrasonic wave 5130 is sent from the transducer to the catheter 5120 and the catheter has been calibrated such that it can detect the dose of ultrasound. The dose allows the absorption of ultrasound to be determined along the path from therapeutic ultrasound to catheter. For example, the equation to model absorption along the path to the catheter can be validated with these data as input power (from catheter) can be recorded at the depth where the catheter is placed.

FIG. 8G depicts proof of concept for the internally placed ultrasound beacon 5340. A fluoroscopic image 5300 is depicted with the catheter in place during an experimental demonstration of the tracking of the beacon. It has been shown that the beacon 5340 may be centered in the blood vessel 5310 which allows for symmetric treatment of the blood vessel. Calibration was performed to optimize the centering of the beacon. A relatively stiff guidewire 5320 was placed through the beacon and the tip of the wire was placed inside a blood vessel within the kidney. With the guidewire tethered inside the blood vessel, the beacon can be moved along the guidewire with relative stability and with the beacon within the center of the blood vessel. The beacon was carried through a guide catheter 5315. A detector 5350 was able to detect the position of the beacon 5340 to within 500 microns of accuracy at a repetition rate of over 50 per second (50 Hz). Therefore, in some embodiments, one method of treatment includes: placing a substantially stiff guidewire inside a blood vessel with one side tethered inside a blood vessel inside a kidney and a second side which passes into the aorta and outside the patient; passing a catheter with an ultrasound probe over the guidewire and to a position in a blood vessel leading to a kidney; applying a signal to activate the piezoelectric crystal of the ultrasound probe; detecting the generated piezoelectric signal from the probe outside of the patient with a piezoelectric detector or other ultrasound detector array; and inputting the detection information into an algorithm which allows for determination of the position of the ultrasound probe within the blood vessel and within the patient. Subsequently, focused, relatively focused, or unfocused energy may be applied to the region around the beacon. Again, it is important that the beacon be centered inside the blood vessel to allow for optimal (symmetric) targeting of the blood vessel. Any of the embodiments of the technique provided herein may be used for centering of the ultrasound beacon.

FIG. 8H depicts the resolution 5345 of the beacon within the blood vessel and detected with the transducers 5350 on the outside of the patient (FIG. 8I). The resolution 5345 is within 50-100 microns in some embodiments. Importantly, the beacon is shown inside the blood vessel at the center of the blood vessel. A methodology has been developed in which the beacon resides at the center of the blood vessel which is important for a symmetric treatment on the outside of the vessel. By placing a wire through the center of beacon (the beacon part of a catheter), the wire stabilizes the beacon inside the vessel by fixing its proximal and distal ends. The distal end is wedged in an artery inside the kidney, the proximal end is fixed through a curve which enters the aorta, and then at the most proximal end by the catheter hub at the operator. These points of fixation maintain the catheter in position which is important during treatment to maintain fidelity between the coupling of the fiducial and the treatment energy system.

FIGS. 8E and 8F depict cross sectional 5200 imaging of the abdomen. Energy waves 5230 are depicted traveling from a posterior direction through the skin to focus 5242 on the region of the blood vessels 5210 leading to the kidney. Device 5240 can be placed outside the patient on the skin of the patient, which transmit the waves 5230 to a nerve region surrounding a blood vessel. CT or MRI imaging can be utilized during the procedure to help direct the waves to the correct location. In the instance when the waves are in the wrong location, the focus 5242 can be redirected to the preferred focal region. In addition, or alternatively, thermal imaging (e.g. with infrared or laser light) may be used.

In another embodiment, the physiologic process of arterial expansion (aneurysms) is targeted. In FIG. 9a, an ultrasound transducer is 6005 is placed near the wall of an aorta 6030. Ultrasonic energy 6015 is applied to the wall 6030 of the aorta to ablate autonomic nerves in the wall region. Once the wall of the aorta is heated with ultrasonic energy to a temperature of between 40 and 70 degrees, the collagen, elastin, and other extracellular matrix (e.g. nerves) in the wall will be ablated.

The energy can also be applied from a position external to the patient or through a percutaneously positioned energy delivering catheter 6005.

FIG. 9
b
6000 depicts another variant of the energy delivery technology in FIG. 9A. The ultrasound catheter 6005 is applied to the aorta 6010 in the center of the aorta so as to symmetrically inhibit nerves surrounding the aorta 6010.

FIG. 9C depicts a device and method 6010 in which the celiac plexus 6020 close to the aorta 6020 is ablated or partially heated using heat or vibrational energy from an ultrasonic energy source 6005 which can apply focused or unfocused sound waves 6007 at frequencies ranging from 20 kilohertz to 5 Mhz and at powers ranging from 1 mW to over 100 kW in a focused or unfocused manner. Full, or partial ablation of the celiac plexus 6020 can result in a decrease in blood pressure via a similar mechanism as applying ultrasonic energy to the renal nerves; the ablation catheter is a focused ultrasound catheter but can also be a direct (unfocused) ultrasonic, a microwave transducer, or a resistive heating element. Energy can also be delivered from an external position through the skin to the aorta or celiac plexus region.

FIG. 10 depicts a method 6100 to treat a patient with high intensity or low intensity focused ultrasound (HIFU or LIFU) 6260. In a first step, a CT and/or MRI scan and/or thermography and/or ultrasound (1D, 2D, 3D) is performed 6110. A fiducial or other marking on or in the patient 6120 is optionally used to mark and track 6140 the patient. The fiducial can be an implanted fiducial, a temporary fiducial placed internally or externally (e.g. the patch locators described above) in or on the patient, or a fiducial intrinsic to the patient (e.g. bone, blood vessel, arterial wall, speckles, doppler signals, etc.) which can be imaged using the CT/MRI/Ultrasound devices 6110. The fiducial can further be a temporary fiducial such as a catheter temporarily placed in an artery or vein of a patient or a percutaneously placed catheter. A planning step 6130 for the HIFU treatment is performed in which baseline readings such as position of the organ and temperature are determined; a HIFU treatment is then planned using a model (e.g. finite element model) to predict heat transfer, or pressure to heat transfer, from the ultrasound transducers 6130. The planning step incorporates the information on the location of the tissue or target from the imaging devices 6110 and allows placement of the anatomy into a three dimensional coordinate reference such that modeling 6130 can be performed.

The planning step 6130 includes determination of the positioning of the ultrasound transducers as far as position of the focus in the patient. X, Y, Z, and up to three angular coordinates are used to determine the position of the ultrasonic focus in the patient based on the cross sectional imaging 6110. The HIFU transducers might have their own position sensors built in so that the position relative to the target can be assessed. Alternatively, the HIFU transducers can be rigidly fixed to the table on which the patient rests so that the coordinates relative to the table and the patient are easily obtainable. The flow of heat is also modeled in the planning step 6130 so that the temperature at a specific position with the ultrasound can be planned and predicted. For example, the pressure wave from the transducer is modeled as it penetrates through the tissue to the target. For the most part, the tissue can be treated as water with a minimal loss due to interfaces. Modeling data predicts that this is the case with the frequencies used in these devices (0.5-2.5 Mhz). The relative power and phase of the ultrasonic wave at the target can be determined by the positional coupling between the probe and target. A convective heat transfer term is added to model heat transfer due to blood flow, particularly in the region of an artery. A conductive heat transfer term is also modeled in the equation for heat flow and temperature.

Another variable which is considered in the planning step is the size of the lesion and the error in its position. In the ablation of small regions such as nerves surrounding blood vessels, the temperature of the regions may need to be increased to a temperature of 60-90 degrees Celsius to permanently ablate nerves in the region. Temperatures of 40-60 degrees may temporarily inhibit or block the nerves in these regions and these temperatures can be used to determine that a patient will respond to a specific treatment without permanently ablating the nerve region. Subsequently, additional therapy can be applied at a later time so as to complete the job or perhaps, re-inhibit the nerve regions. In some embodiments, the temperature is only increased a few degrees or not at all, and multiple pulses are delivered, breaking nerve sheaths and nerve bodies by fast impulses of vibratory energy as opposed to heat or in addition to heat. For example, the power density at the nerve may be 1 W/cm²or 100 W/cm². The pulse of vibratory energy may be 0.1 per second, 1 per second, 50 per second, 100 per second, 1000 per second, higher frequency, or lower frequency. In some embodiments, the power may be as low as 100 mW/cm²or 50 mW/cm². The train of pulses may be as long as 30 seconds, 60 seconds, 2-30 minutes, or anywhere in between.

In some embodiments, the temperature inside the blood vessel is measured and held to a temperature of less than 60 degrees Celsius, or less than 70 degrees Celsius, in which case the procedure might be stopped (e.g., when a desired temperature is reached).

An error analysis is also performed during the treatment contemplated in FIG. 10. Each element of temperature and position contains an error variable which propagates through the equation of the treatment. The errors are modeled to obtain a virtual representation of the temperature mapped to position. This map is correlated to the position of the ultrasound transducers in the treatment of the region of interest.

During the delivery of the treatment 6260, the patient may move, in which case the fiducials 6120 track the movement and the position of the treatment zone is re-analyzed 6150 and the treatment is restarted or the transducers are moved either mechanically or electrically to a new focus position. Therefore, the treatment in this embodiment is automated, with a phased array or a mechanical movement system moving the ultrasound focus based on the position of the target. If the movement is extreme and outside a target zone, then the system turns off, and the patient is repositioned.

In another embodiment, a cross-sectional technique of imaging is used in combination with a modality such as ultrasound to create a fusion type of image. The cross-sectional imaging is utilized to create a three dimensional data set of the anatomy. The ultrasound, providing two dimensional images, is linked to the three dimensional imaging provided by the cross-sectional machine through fiducial matches between the ultrasound and the MRI. As a body portion moves within the ultrasound field, the corresponding data is determined (coupled to) the cross-sectional (e.g. MRI image) and a viewing station can show the movement in the three dimensional dataset. The ultrasound provides real time images and the coupling to the MRI or other cross-sectional image depicts the ultrasound determined position in the three dimensional space.

FIG. 11A depicts an algorithm 7000 for tracking movement 7050 and turning the therapy off 7010, and then restarting therapy 7020, or turning therapy off and restarting but adding time 7015 to the overall therapy. The movement might be 1 mm, 2 mm, or 5 mm in any plane of movement. It's important that once the therapy is turned off, that additional time is added back to the overall treatment to retain the effectiveness of the treatment.

FIG. 11B depicts the tracking algorithm visual on the screen during treatment. Distances 7035 can be tracked to 1 mm, 2 mm, or 3 mm and the correct error quantity utilized to determine the shutoff parameters in 11A. The overlapping circles 7030 represent the screen of the treatment as the treatment proceeds showing the target as it moves during treatment. When the target moves beyond 1-2 mm or other distance deemed unsafe, the treatment is turned off and then restarted with the treatment time added back to the total.

FIG. 12 depicts a laparoscopic based approach 8000 to the renal artery region in which the sympathetic nerves 8210 can be ligated, interrupted, or otherwise modulated. In laparoscopy, the abdomen of a patient is insufflated and laparoscopic instruments introduced into the insufflated abdomen. The retroperitoneum is easily accessible through a flank approach or (less so) through a transabdominal (peritoneal) approach. A laparoscopic instrument 8200 with a distal tip 8220 can apply heat or another form of energy or deliver a drug to the region of the sympathetic nerves 8210. The laparoscopic instrument can also be utilized to ablate or alter the region of the celiac plexus 8300 and surrounding ganglia. The laparoscope can have an ultrasound transducer 8220 attached, a temperature probe attached, a microwave transducer attached, or a radiofrequency transducer attached. The laparoscope can be utilized to directly ablate or stun the nerves (e.g. with a lower frequency/energy) surrounding vessels or can be used to ablate or stun nerve ganglia which travel with the blood vessels. Similar types of modeling and imaging can be utilized with the percutaneous approach as with the external approach to the renal nerves. With the discovery through animal experimentation (see below) that a wide area of nerve inhibition can be affected with a single ultrasound probe in a single direction (see above), the nerve region does not have to be directly contacted with the probe, the probe instead can be directed in the general direction of the nerve regions and the ultrasound delivered. For example, the probe can be placed on one side of the vessel and activated to deliver focused or semi-focused ultrasound over a generalized region which might not contain greater than 1 cm of longitudinal length of the artery but its effect is enough to completely inhibit nerve function along. The ultrasound is transmittable through the artery from one side of the artery. This is shown and described below in which the ultrasound focus is delivered to both walls of the artery simultaneously by transmitting the ultrasound through the blood vessel from one direction.

FIG. 13 depicts an algorithm 8400 for the treatment of a region of interest using directed energy from a distance. MRI and/or CT with or without an imaging agent 8410 can be utilized to demarcate the region of interest (for example, the ablation zone) and then ablation 8420 can be performed around the zone identified by the agent using any of the modalities above. This algorithm is applicable to any of the therapeutic modalities described above including external HIFU, laparoscopic instruments, intravascular catheters, percutaneous catheters and instruments, as well as any of the treatment regions including the renal nerves, the eye, the kidneys, the aorta, or any of the other nerves surrounding peripheral arteries or veins. Imaging 8430 with CT, MRI, ultrasound, or PET can be utilized in real time to visualize the region being ablated. At such time when destruction of the lesion is complete 8440, imaging with an imaging (for example, a molecular imaging agent or a contrast agent such as gadolinium) agent 8410 can be performed again. The extent of ablation can also be monitored by monitoring the temperature or the appearance of the ablated zone under an imaging modality. Once lesion destruction is complete 8440, the procedure is finished. In some embodiments, ultrasonic diagnostic techniques such as elastography are utilized to determine the progress toward heating or ablation of a region.

FIG. 14 depicts ablation in which specific nerve fibers of a nerve are targeted using different temperature gradients, power gradients, or temperatures 8500. For example, if temperature is determined by MRI thermometry or with another technique such as ultrasound, infrared thermography, or a thermocouple, then the temperature can be kept at a temperature in which only certain nerve fibers are targeted for destruction or inhibition. For example, C fibers may be targeted, or A fibers may be targeted with such a technique. C fibers are unmyelinated and are responsible for afferent nerve traffic from the kidney to the central nervous system, and may be the major nerves responsible for decreasing blood pressure. Specifically targeting these nerves would allow more precise, and possibly safer, treatment to be applied to the renal nerves. Alternatively, part or all of the nerve can be turned off temporarily to then test the downstream effect of the nerve being turned off. For example, the sympathetic nerves around the renal artery can be turned off with a small amount of heat or other energy (e.g. vibrational energy) and then the effect can be determined. For example, norepinephrine levels in the systemic blood, kidney, or renal vein can be assayed; alternatively, the stimulation effect of the nerves can be tested after temporary cessation of activity (e.g. skin reactivity, blood pressure lability, cardiac activity, pulmonary activity, renal artery constriction in response to renal nerve stimulation). For example, in one embodiment, the sympathetic activity within a peripheral nerve is monitored; sympathetic activity typically manifests as spikes within a peripheral nerve electrical recording. The number of spikes correlates with the degree of sympathetic activity or over-activity. When the activity is decreased by (e.g. renal artery de-innervation), the concentration of spikes in the peripheral nerve train is decreased, indicating a successful therapy of the sympathetic or autonomic nervous system. Varying frequencies of vibration can be utilized to inhibit specific nerve fibers versus others. For example, in some embodiments, the efferent nerve fibers are inhibited and in other embodiments, the afferent nerve fibers are inhibited. In some embodiments, both types of nerve fibers are inhibited, temporarily or permanently. In some embodiments, the C fibers 8520 are selectively blocked at lower heat levels than the A nerve fibers. In other embodiment, the B fibers are selectively treated or blocked and in some embodiments, the A fibers 8530 are preferentially blocked. In some embodiments, all fibers are inhibited by severing the nerve with a high dose of ultrasound 8510. Based on the experimentation described above, the power density to achieve full blockage might be around 100-800 W/cm²or with some nerves from about 500 to 2500 W/cm². In some embodiments, a pulse train of 100 or more pulses each lasting 1-2 seconds (for example) and delivering powers from about 50 w/cm²to 500 W/cm². Indeed, prior literature has shown that energies at or about 100 W/Cm²is adequate to destroy or at least inhibit nerve function (Lele, PP. Effects of Focused Ultrasound Radiation on Peripheral Nerve, with Observations on Local Heating. Experimental Neurology 8, 47-83 1963). Based on data obtained in proof of concept, the ramp up to the correct power is desirable in some embodiments due to the nature of the region in which there is a tremendous amount of perfusion through the large blood vessels through the renal vein, artery, vena cava, etc. Modeling indicates that a slow increase in power ramp up allows the blood vessels to remove a greater amount of heat than when the rise in temperature is performed within a few seconds. Therefore, a faster ramp of power to the target region is desirable to heat structures close to the artery.

FIG. 15A depicts various treatment patterns to inhibit the nerves traveling to the kidney. In FIG. 15A, an artery 8627 is depicted (arrow depicts blood flow). The artery is imaged by MRI, ultrasound, etc. and then a therapeutic energy 8625 is delivered to the artery. The therapeutic energy can be ionizing radiation, ultrasound radiation, or electromagnetic radiation focused on the nerve region 8630. FIG. 15B depicts another method to inhibit the nerves 8640 in which the blood flows (arrow traveling away from the kidney) in the renal vein 8635. FIG. 15C depicts multiple renal arteries 8642 traveling to a kidney 8645. Because the nerves are in bundles between the arteries and the focused ultrasound 8647 is only relatively focused, the nerves between the multiple renal blood vessels 8642 can be treated with the focused ultrasound.

FIG. 16A depicts a set of lesion types, sizes, and anatomies 8710 which lead to de-innervation of the different portions of the sympathetic nerve tree around the renal artery. For example, the lesions can be annular, cigar shaped, spiral 8707, linear 8714, doughnut and/or spherical; the lesions can be placed around the renal arteries 8705, inside the kidney 8712, 8718, and/or around the aorta (8714, 8716). For example, the renal arterial tree comprises a portion of the aorta 8700, the renal arteries 8705, and kidneys 8715. Lesions 8714 and 8716 are different types of lesions which are created around the aorta 8700 and vascular tree of the kidneys. Lesions 8712 and 8718 are applied to the pole branches from the renal artery leading to the kidney and inhibit nerve functioning at branches from the main renal artery. These lesions also can be applied from a position external to the patient. Lesions can be placed in a spiral shape 8707 along the length of the artery as well. These lesions can be produced using energy delivered from outside the blood vessels using a completely non-invasive approach in which the ultrasound is applied through the skin to the vessel region or the energy can be delivered via percutaneous approach. Either delivery method can be accomplished through the posterior approach to the blood vessels as discovered and described above.

In one method therefore, ultrasound energy can be applied to the blood vessel leading to a kidney in a pattern such that a circular pattern of heat and ultrasound is applied to the vessel. The energy is transmitted through the skin in one embodiment or through the artery in another embodiment. As described below, ultrasound is transmitted from a distance and is inherently easier to apply in a circular pattern because it doesn't only rely on conduction.

Previously, it was unknown and undiscovered whether or not the annular shaped lesions as shown in FIG. 16a would have been sufficient to block nerve function of the autonomic nerves around the blood vessels. Applicant of the subject application discovered that the annular shaped ablations 8710 not only block function but indeed completely block nerve function around the renal artery and kidney and with very minimal damage (FIG. 16C), if any, to the arteries and veins themselves. Data out to over 1 yr show that the artery is unaffected in the long term by an annular heating power which is in direct contrast to the teaching of U.S. Pat. No. 8,145,136 column 16 lines 55-60. In these experiments based on the inventions of this patent, focused ultrasound was used to block the nerves; the ultrasound was transmitted through and around the vessel from the top (that is, only one side of the vessel) at levels of 200-2500 W/cm². The energy travels through the flowing blood to affect the opposite side of the blood vessel. Simulations are shown in FIGS. 16B and 16D and described below. Norepinephrine levels in the kidney 8780, which are utilized to determine the degree of nerve inhibition, were determined before and after application of energy. The lower the levels of norepinephrine, the more nerves which have been inhibited or affected. In these experiments which were performed, the norepinephrine levels approached zero 8782 versus controls (same animal, opposite kidney) 8784 which remained high. In fact, the levels were equal to or lower than the surgically denuded blood vessels (surgical denudement involves directly cutting the nerves surgically and application of phenol to the vessel wall). It is important to note that the renal artery and vein walls remained substantially unharmed; this is likely due to the fact that the quick arterial blood flow removes heat from the vessel wall and the fact that the main renal artery is extremely resilient due to its large size, high blood flow, and thick wall; these findings are consistent with the modeling performed as shown in FIGS. 16B and 16D. To summarize, ultrasound (focused and relatively unfocused) was applied to one side of the renal artery and vein complex. The marker of nerve inhibition, norepinephrine levels inside the kidney, were determined to be approaching zero after application to the nerves from a single direction, transmitting the energy through the artery wall to reach nerves around the circumference of the artery. The level of zero norepinephrine 8782 indicates essentially complete abolition of nerve function proving that the annular lesions were in fact created as depicted in FIG. 16A and simulated in FIGS. 16B and 16D. Histological results also confirm the annular nature of the lesions and limited collateral damage as predicted by the modeling in 16B.

Therefore, in one embodiment, the ultrasound is applied from a position external to the artery in such a manner so as to create an annular or semi-annular rim of heat all the way around the artery to inhibit, ablate, or partially ablate the autonomic nerves surrounding the artery. The walls or the blood flow of the artery can be utilized to target the ultrasound to the nerves which, if not directly visualized, are visualized through use of a model to approximate the position of the nerves based on the position of the blood vessel.

FIG. 16B further supports the physics and physiology described herein, depicting a theoretical simulation 8750 of the physical and animal experimentation described above. That is, focused ultrasound was targeted to a blood vessel in a computer simulation 8750. The renal artery 8755 is depicted within the heating zone generated within a focused ultrasound field. Depicted in the figure is the temperature at <1 s 8760 and at approximately 5 s 8765 and longer time >10 s 8767. Flow direction 8770 is shown as well. The larger ovals depict higher temperatures with the central temperature >100° C. The ultrasound field is transmitted through the artery 8755, with heat building up around the artery as shown via the temperature maps 8765. Importantly, this theoretical simulation also reveals the ability of the ultrasound to travel through the artery or blood vessel 8767 and affect both walls of the blood vessel. These data are consistent with the animal experimentation described above, creating a unified physical and experimental dataset. In some cases, the ultrasonic energy may be applied to the blood vessel quickly to avoid removal of the heat by the blood flow. In the case where the ultrasound ramp up around the vessel is not applied quickly, a steady state is reached in which the heat applied is equal to the heat dissipated, and it may become difficult to heat the rim of the blood vessel.

FIG. 16C depicts the results of an experimental focused ultrasound treatment in which one kidney was treated with the ultrasound and the other served as a control. Norepinephrine 8780 is the marker of the effect of sympathetic nerve inhibition and its concentration was measured in the cortex of the kidney. The experimental result 8782 was very low compared to the control 8784 level indicating almost complete inhibition of the nerves which travel to the kidney. A circumferential effect of the heat is provided to obtain such a dramatic effect on norepinephrine levels leading to the kidney.

FIG. 16D is a depiction of a simulation with multiple beams being applied to the region of the blood vessel wall. The ultrasound might be scanned toward the blood vessel or otherwise located point by point within the treatment region. In one embodiment, the power to the blood vessel is delivered such that the temperature ramps over 60 degrees within 2 s or within 5 s or within 10 s. Subsequently, the energy is turned off and then reapplied after a period of 1, 2, 5, or 10 seconds. In some embodiments, the energy may be on for a prescribed duration, such as 1, 2, 5, 10 seconds, etc. In some embodiments, a technique such as infrared thermography or laser Doppler thermography is used to determine the temperature of the skin and subcutaneous tissue to decide when it is safe to deliver an additional dose of energy to the target zone. Such a treatment plan creates a cloud of heat centered on the inside of the wall of the blood vessel. In other embodiments, the energy may be on for 30, 60, or 90 seconds, but the power is lower than that for the shorter on-time periods of 1, 2, 5, 10 seconds.

Similarly, other vessels leading to other organs which rely on sympathetic, parasympathetic, and general autonomic innervation can be treated as well utilizing this technique. Referring to FIG. 5C, blood vessels which lead to the eye 2105/2128 (carotid artery), the mouth (facial arteries) and saliva glands 2107/2126, the heart 2109/2124, the bronchi 2110/2122, the stomach 2112/2121, the gallbladder 2114 and liver 2118, the bladder 2115/2117, the adrenal gland 2116, the pancreas can be stimulated or inhibited utilizing this technique of focused energy delivery targeting a blood vessel. In one example, an underactive pancreas is treated by denervation, which results in improved glucose tolerance. In another embodiment, the liver is denervated by ablated arteries surrounding portal veins or hepatic arteries leading to the liver. Any of the above organs may be denervated using a similar technique as that described with reference to the blood vessels leading to the kidney. In some embodiments, blood vessels in the pulmonary organ are targeted to improve asthmatic symptoms or symptoms related to chronic obstructive pulmonary disease (COPD), or pulmonary hypertension. In one embodiment, a catheter is placed in the pulmonary artery or vein and a circumferential ultrasound treatment performed around the blood vessel using unfocused ultrasound from within the vessel. In another embodiment, the ultrasound is delivered from outside the patient to the pulmonary blood vessel to ablate the nerves surrounding it. In another embodiment, the nerves to the adrenal gland around the adrenal artery are inhibited or ablated using the technology herein.

FIGS. 16D-H depict another simulation with multiple treatment performed over time (up to 132 s) in a pattern such as shown in FIG. 16D. FIG. 16H is a close up of FIG. 16D and depicts a blood vessel 8795 (with a flow rate of the renal artery and renal vein in a human being) and vessel wall 8796. In this simulation, the focused energy was applied in a 10 s on and 6 s off pattern to allow heat to surround 8793 the vessel 8795. The transducer 8790, subcutaneous tissue 8792, and muscle wall 8794 are depicted. This simulation reveals the ability of focused energy to create a cloud around the blood vessel particularly with high blood flow such as to the kidney. FIG. 16E is a similar simulation to 16D but in a different plane. FIGS. 16F and 16G represent different times (time=132 s) in two different planes as well.

FIGS. 16 I,J,K depict some of the patterns which can be applied to a blood vessel. In FIG. 16D, application of the focused energy 8770 to the vessel is shown in a pattern created by the transducer mover. FIG. 16J depicts another type of pattern 8772 with a broader brush stroke around the vessel.

FIG. 16I
8770 and FIG. 16J8772 depict cross sectional patterns across a blood vessel. FIG. 16K depicts a longitudinal pattern 8774 along the vessel.

FIGS. 16L and 16M depict the results of an experiment 8787 in which nerves leading to the kidney are treated with heat from an externally applied source, and nerves inhibited from producing norepinephrine.

FIG. 16L depicts the results of an experiment in which the HIFU 8644 was compared to a surgical control 8648. HIFU was applied across the vessel so that the ultrasound passed through the blood and the vessel to affect both walls of the vessel. As can be seen in the FIG. 16L, the HIFU applied from outside the patient is as good as denervation with surgery revealing that focused ultrasound can indeed remove, inhibit, or ablate nerves surrounding blood vessels. To the extent nerves are contained within the walls of the blood vessel, focused ultrasound can be used to inhibit or ablate the nerves within the media of the blood vessel wall.

FIG. 16M depicts a similar experiment 8787 in which focused ultrasound is applied through the skin to the nerves surrounding the blood vessels traveling to the kidney. Bar 8788 is a control kidney and 8778 is a therapy kidney. A pattern of heat is applied to the blood vessel over a 2-3 minute period resulting in the observed changes in norepinephrine and indicating denervation of the sympathetic nerves around a blood vessel leading to an organ.

As can be seen, the control side 8788, 8644, 8646, 8648 reveal a high norepinephrine level and the therapy side 8778, 8649 reveals a low norepinephrine level, indicating treatment was successful. This experiment was performed utilizing an externally placed ultrasound system which focused the energy on the nerves in one of the patterns shown above.

FIG. 16N depicts another experiment 8797 (low absolute dose) with multiple time points revealing that the norepinephrine levels remain low for at least several weeks 8798, 8799, 8796 after the treatment. Importantly in this experiment, at the doses used, there was no pathologic effect on any other organs, indicating that the threshold for damage to nerves is lower than adjacent organs. Therefore in one method of treatment, ultrasound is applied to the blood vessels leading to the kidneys in such a way to transmit through the blood vessel. The ultrasound continues through the kidney and then to the blood vessel leading to the kidney. At the level of the blood vessel, after attenuation in the tissue, the power density at the blood vessel may be 10 W/Cm2 to 800 W/cm2, and preferably may be 150 to 500 W/cm2, for several seconds until a proper amount of heating has occurred. Vibration rather than heat is the predominant mechanism responsible for nerve inhibition and damage at the doses in this embodiment. Therefore, heat is not necessarily required for ablation or blockage of the nerves leading to the kidney, and vibration with only moderate temperature rise may be used in some cases. Examples of patterns and on-off periods include circular patterns around the blood vessel with on-off times of 7 s and 5 s respectively, or on-off times of 12 s-30 s respectively. Patterns around the blood vessel include circumferential patterns with diameter of 1 cm or 1.2 or 1.5 cm. The circumferential pattern might include 5, 10, 15, or 20 separate “shots” targeted around the vessel utilizing the vessel wall as the target point. Other on-off times include 6-6, 10-5, etc.

Therefore, based on the animal and theoretical experimentation, there is proven feasibility of utilizing ultrasound to quickly and efficiently inhibit the nerves around the renal arteries from a position external to the blood vessels as well as from a position external to the skin of the patient.

The pattern of application may be different from systems to treat tumors and other pathologies in which it is desired that 100% of the region be treated. The nerve region surrounding the blood vessels is diffuse and it is not necessary to inhibit all nerves in order to have an effect on blood pressure. Therefore, the goal is to apply broad brush strokes of energy across the vessel to create an annular zone, or cloud of heat around the vessel. Subsequent to a first treatment, a second treatment may be applied in which additional nerves are affected. The second treatment may occur minutes, hours, days, or years after the treatment, and may depend on physiological changes or regrowth of the nerves. In some cases, a quality factor is calculated based on the degree of movement of the applicator. The quality factor relates to the degree of time the applicator actually was focused on the identified target. Although 100% is ideal, sometimes it may not be achieved. Therefore, in some cases, when the applicator focuses on the target for 90% of the time, the treatment may be considered successful. In other embodiments, the quality factor might be the amount of time the targeted region is actually within 90% of the target, for example, within 500 microns of the target, or within 1 mm of the target, or within 2 mm of the target, etc. The detection of the target is determined via imaging, internal fiducial, and/or external fiducial.

Utilizing the experimental simulations and animal experimentation described above, a clinical device 1200 can and has been devised and tested in human patients. FIG. 17A depicts a multi-transducer HIFU device 1100 which applies a finite lesion 1150 along an artery 1140 (e.g. a renal artery) leading to a kidney 1130. The lesion can be spherical in shape, cigar shaped 1150, annular shaped 8710 (FIG. 16A), or point shaped; however, in a preferred embodiment, the lesion runs along the length of the artery and has a cigar shape 1150. This lesion is generated by a spherical or semi-spherical type of ultrasound array in a preferred embodiment. Multiple cigar shaped lesions as shown in FIG. 17C lead to a ring type of lesion 1350 around the artery 1340. The lesions can be spherical, cylindrical, ellipsoidal, cloud shaped. On lesion can be broad and center on the blood vessel or the lesion can be created via multiple transducer positions.

FIG. 17B depicts an imaging apparatus display 1300 which monitors treatment. Lesion 1150 is depicted on the imaging apparatus as is the aorta 1160 and renal artery 1155. The image might depict heat, tissue elastography, vibrations, temperature or might be based on a simulation of the position of the lesion 1150. MRI, CT, infrared thermography, ultrasound, laser thermography, or thermistors may be used to determine temperature of the tissue region. FIG. 17C depicts another view of the treatment monitoring, with the renal artery in cross section 1340. Lesion 1350 is depicted in cross section in this image as well. The lesion 1350 might be considered to circumscribe the vessel 1340 in embodiments where multiple lesions are applied.

FIG. 17D depicts a methodology 1500 to analyze and follow the delivery of therapeutic focused ultrasound to an arterial region. A key step is to first position 1510 the patient optimally to image the treatment region; the imaging of the patient might involve the use of Doppler imaging, M mode imaging, A scan imaging, or even MRI, fluoroscopy, or CT scan. The imaging unit is utilized to obtain coordinate data 1530 from the doppler shift pattern of the artery. Next, the focused ultrasound probe is positioned 1520 relative to the imaged treatment region 1510 and treatment can be planned or applied.

FIG. 17E depicts the pathway of the acoustic waves from a spherical or cylindrical type of ultrasound array 1600. In some embodiments, the transducer is aspherical such that a sharp focus does not exist but rather the focus is more diffuse in nature or off the central axis. Alternatively, the asphericity might allow for different path lengths along the axis of the focusing. For example, one edge of the ultrasound transducer might be called upon for 15 cm of propagation while another edge of the transducer might be called upon to propagate only 10 cm, in which case a combination of different frequencies or angles might be required.

Ultrasound transducers 1610 are aligned along the edge of a cylinder 1650, aimed so that they intersect at one or more focal spots 1620, 1630, 1640 around the vessel (e.g. renal artery). The transducers 1610 are positioned along the cylinder or sphere or spherical approximation (e.g. aspherical) 1650 such that several of the transducers are closer to one focus or the other such that a range of distances 1620, 1630, 1640 to the artery is created. The patient and artery are positioned such that their centers 1700 co-localize with the center of the ultrasound array 1600. Once the centers are co-localized, the HIFU energy can be activated to create lesions along the length of the artery wall 1640, 1620, 1630 at different depths and positions around the artery. The natural focusing of the transducers positioned along a cylinder as in FIG. 17E is a lengthwise lesion, longer than in thickness or height, which will run along the length of an artery 1155 when the artery 1340 is placed along the center axis of the cylinder. When viewed along a cross section (FIG. 17F), the nerve ablations are positioned along a clock face 1680 around the blood vessel.

In another embodiment, a movement system for the transducers is utilized so that the transducers move along the rim of the sphere or cylinder to which they are attached. The transducers can be moved automatically or semi-automatically, based on imaging or based on external position markers. The transducers are independently controlled electrically but coupled mechanically through the rigid structure.

Importantly, during treatment, a treatment workstation 1300 (FIG. 17C) gives multiple views of the treatment zone with both physical appearance and anatomy 1350.

Physical modeling is performed in order to predict lesion depth and the time to produce the lesion; this information is fed back to the ultrasound transducers 1100. The position of the lesion is also constantly monitored in a three dimensional coordinate frame and the transducer focus at lesions center 1150 in the context of monitoring 1300 continually updated. The system receives continuous or intermittent inputs regarding treatment depth, position, and movement of the patient and then outputs this information to the transducer and operator to continuously update the treatment plan to improve treatment accuracy and efficacy.

In some embodiments, motion tracking prevents the lesion or patient from moving too far out of the treatment zone during the ablation. If the patient does move outside the treatment zone during the therapy, then the therapy can be stopped. For example, the threshold for movement might be 1 mm, 2 mm, 3 mm or 10 mm depending on the quality of treatment preferred by the operator or dictated by the anatomy. Motion tracking can be performed using the ultrasound transducers, tracking frames and position or with transducers from multiple angles, creating a three dimensional image with the transducers. Alternatively, a video imaging system can be used to track patient movements, as can a series of accelerometers positioned on the patient which indicate movement. In some cases, this embodiment can include a quality factor used to change the dose delivered to the patient based on movement which tends to smear the delivered dose, as described herein.

FIG. 18 depicts a micro-catheter 8810 which can be placed into renal calyces 8820; this catheter allows the operator to specifically ablate or stimulate 8830 regions of the kidney 8800. The catheter can be used to further allow for targeting of the region around the renal arteries and kidneys by providing additional imaging capability or by assisting in movement tracking or reflection of the ultrasound waves to create or position the lesion. The catheter or device at or near the end of the catheter may transmit signals outside the patient to direct an energy delivery device which delivers energy through the skin. Signaling outside the patient may comprise energies such as radiofrequency transmission outside the patient or radiofrequency from outside to the inside to target the region surrounding the catheter. The following patent and patent applications describe the delivery of ultrasound using a targeting catheter within a blood vessel, and are expressly incorporated by reference herein:

Ser. Nos. 11/583,569, 12/762,938, 11/583,656, 12/247,969, 10/633,726, 09/721,526, 10/780,405, 09/747,310, 12/202,195, 11/619,996, 09/696,076

In one system 8800, a micro catheter 8810 is delivered to the renal arteries and into the branches of the renal arteries in the kidney 8820. A signal is generated from the catheter into the kidney and out of the patient to an energy delivery system. Based on the generated signal, the position of the catheter in a three dimensional coordinate reference is determined and the energy source is activated to deliver energy 8830 to the region indicated by the microcatheter 8810. In one embodiment, the signal communicates with a stereotactic radiotherapy device which can deliver ionizing radiation from outside the patient to the region of the blood vessels traveling to or from the kidney.

In an additional embodiment, station keeping is utilized. Station keeping enables the operator to maintain the position of the external energy delivery device with respect to the movement of the operator or movement of the patient. As an example, targeting can be achieved with the energy delivery system and tracking of movement of the energy delivery system relative to the target. As the energy delivery system moves from its initial state, the station keeping allows the focus to be moved with the target as the target moves from its original position. Such station keeping is described herein and illustrated in FIGS. 19C-D. A quality factor may be used by the device to increase or decrease dosing depending on the degree of movement. The quality factor may be defined as the percentage of time within a pre-specified target zone. For example, if the quality factor deviation from a desired value by a certain amount (for example 10% or 1 mm of a 10 mm target zone), then the dose may be increased or decreased to accommodate such motion.

The microcatheter may be also be utilized to place a flow restrictor inside the kidney (e.g. inside a renal vein) to “trick” the kidney into thinking its internal pressure is higher than it might be. In this embodiment, the kidney generates signals to the central nervous system to lower sympathetic output to target organs in an attempt to decrease its perfusion pressure.

Alternatively, specific regions of the kidney might be responsible for hormone excretion or other factors which lead to hypertension or other detrimental effects to the cardiovascular system. The microcatheter can generate ultrasound, radiofrequency, microwave, or X-ray energy, or inject bioactive agents into the region. The microcatheter can be utilized to ablate regions in the renal vein or intra-parenchymal venous portion as well. In some embodiments, ablation is not required but vibratory energy emanating from the probe is utilized to affect, on a permanent or temporary basis, the mechanoreceptors or chemoreceptors in the location of the hilum of the kidney.

FIG. 19A depicts the application 8900 of energy to the region of the renal artery 8910 and kidney 8920 using physically separated transducers 8930, 8931. Although two are shown, the transducer can be a single compound transducer, on which several transducer are connected together along an outer frame. The transducer(s) can be spherical (sharp focus) or aspherical (diffuse focus), they can be coupled to an imaging transducer directly or indirectly where the imaging unit might be separated at a distance. In contrast to the delivery method of FIG. 17, FIG. 19A depicts delivery of ultrasound transverse to the renal arteries and not longitudinal to the artery. The direction of energy delivery is the posterior of the patient because the renal artery is the first vessel “seen” when traveling from the skin toward the anterior direction facilitating delivery of the therapy. In one embodiment, the transducers 8930, 8931 are placed under, or inferior to the rib of the patient or between the ribs of a patient; next, the transducers apply an ultrasound wave propagating forward toward the anterior abdominal wall and image the region of the renal arteries and renal veins, separating them from one another. In some embodiments, such delivery might be advantageous, if for example, a longitudinal view of the artery is unobtainable or a faster treatment paradigm is desirable. The transducers 8930, 8931 communicate with one another and are connected to a computer model of the region of interest being imaged (ROI), the ROI based on an MRI scan performed just prior to the start of the procedure and throughout the procedure. Importantly, the transducers are placed posterior in the cross section of the patient, an area with more direct access to the kidney region. The angle between the imaging transducers can be as low as 3 degrees or as great as 180 degrees depending on the optimal position in the patient.

In another embodiment, an MRI is not performed but ultrasound is utilized to obtain all or part of the cross-sectional view in FIG. 19A. For example, 8930, 8931 might contain an imaging transducer as well as a therapeutic energy source (e.g. ionizing energy, HIFU, low energy focused ultrasound, etc.) In some embodiments, a CT scan is utilized, which can obtain two dimensional images and output three dimensional images. In other embodiments, a fluoroscopy unit may be used.

FIG. 19B depicts an ultrasound image from a patient illustrating imaging of the region with patient properly positioned as described below. It is this cross section that can be treated with image guided HIFU of the renal hilum region. The kidney 8935 is visualized in cross section and ultrasound then travels through to the renal artery 8937 and vein 8941. The distance can be accurately measured 8943 with ultrasound (in this case 8 cm 8943). This information is useful to help model the delivery of energy to the renal blood vessels. The blood vessels (vein and/or artery) are utilized as fiducials for the targeting of the ultrasound, and the kidney is used to verify that the vessels indeed are leading to the correct organ. The kidney is further utilized to conduct the ultrasound to the blood vessels. In this embodiment, the kidney is utilized as a targeting fiducial to direct the operator where to direct the energy. Once the direction and orientation of the renal artery and kidney are determined, the therapeutic ultrasound is delivered to the region of the renal hilum. Therefore, the kidney and blood vessels leading to the kidney are the fiducials which indicate the desired orientation of the therapeutic ultrasound (e.g., toward the renal hilum).

FIGS. 19C-D depicts an actual treatment of the renal hilum 8645. A targeting region 8647, 8946 is shown in which movement of the transducer and hilum is tracked and analyzed 8949, 8951 and 8948. The accuracy of the tracking is recorded and displayed 8948 over time. In this figure, the cool off period is shown and in FIG. 19D treatment 8954 is shown. In some embodiments, energy is delivered in the manner described herein through the kidney, which has been shown to be resilient to heat. In some cases, movement of the renal hilum and the transducer are recorded in real time, and therapy of the blood vessels is depicted in real time during the treatment. Success of tracking may, as well as progress of the therapy at the time of treatment, may be presented on a screen for viewing by the user as shown in the tracking bar below the ultrasound image. Success may be considered when the targeting is maintained within the target circle 8647 at least 90% of the time of each treatment. This targeting accuracy is generally attributed to success in the pre-clinical studies described below. A motion tracking system is built into the system to ensure that a proper dose is delivered to the region of the renal nerves leading to the kidney. The motion tracking system relates the coordinates in three dimensions to the treatment, and allows for the quality of the treatment to be determined. Therefore, in one embodiment, focused energy is applied to the region of the blood vessels to the kidney; hardware and software is utilized to quantify the degree of movement between the treatment device and the treatment region; a quality factor is utilized to ascertain whether additional time needs to be added to the treatment if the quality factor is too low to yield an effective treatment.

FIG. 19E depicts a clinical method based on the treatment shown in FIGS. 19C-D above. The first step 8972 is to consider a delivery approach to apply ultrasound to nerves surrounding a blood vessel. The next step is to generate an ultrasound image of the region 8960 and the subsequent step is to determine the distance 8962 to the blood vessel and then integrate the plan with the HIFU transducer 8964. Based on data generated above, parameters are determined to apply pulses, generally less than 10 s of “on” time, to ramp the temperature 8966 of the region around the blood vessel to approximately 200 W/cm²in at least 2 seconds 8970. The focus is then moved along the artery or blood vessel 8968 from anterior to posterior and/or from side to side.

FIG. 20 depicts an alternative method, system 9000 and device to ablate the renal nerves 9015 or the nerves leading to the renal nerves at the aorta-renal artery ostium 9010. The intravascular device 9020 is placed into the aorta 9050 and advanced to the region of the renal arteries 9025. Energy is applied from the transducer 9020 and focused 9040 (in the case of HIFU, LIFU, ionizing radiation) to the region of the takeoff of the renal arteries 9025 from the aorta 9050. This intravascular 9030 procedure can be guided using MRI and/or MRI thermometry or it can be guided using fluoroscopy, ultrasound, or MRI. Because the aorta is larger than the renal arteries, the HIFU catheter can be placed into the aorta directly and cooling catheters can be included as well. In addition, in other embodiments, non-focused ultrasound can be applied to the region around the renal ostium or higher in the aorta (e.g. at the level of the celiac, inferior, or superior mesenteric plexus). Non-focused, or relatively unfocused ultrasound in some embodiments may require cooling of the tissues surrounding the probe using one or more coolants but in some embodiments, the blood of the aorta will take the place of the coolant, by its high flow rate; HIFU, or focused ultrasound, may not need the cooling because the waves are by definition focused from different angles to the region around the aorta. The vena cava and renal veins can also be used as a conduits for the focused ultrasound transducer to deliver energy to the region as well. In one embodiment, the vena cava is accessed and vibratory energy is passed through the walls of the vena cava and renal vein to the renal arteries, around which the nerves to the kidney travel. The veins, having thinner walls, allow energy to pass through more readily.

FIG. 21 depicts other diseases and anatomies which can be treated with the system described. In one embodiment, autonomic nerves surrounding blood vessels which travel to the liver are treated. Diseases such as diabetes, hyperglycemia, and hypoglycemia can be treated. In some embodiments, caloric intake is altered using the devices and methods described in FIG. 21. For example, the sympathetic nerves leading to the liver control certain aspects of caloric uptake from nutrients delivered from the GI tract. The sympathetic nerves can be inhibited and the relative ration of calories to other nutrients can be altered. The nerves can also be inhibited to treat patients during septic shock. For example, norepinephrine release during septic shock has been shown to lead to greater morbidity and mortality in patients with septic shock. Decreasing norepinephrine output will improve outcomes in patients in septic shock. In one embodiment, a catheter 9110 is placed into a hepatic blood vessel such as the hepatic artery or portal vein 9130. The liver 9140 receives sympathetic nerves 9180 from the hepatic blood vessels and delivery of energy to these nerves from a position external to the patient or from a position internal in the vessel will lead to decreased sympathetic activity in the liver and systemic bloodstream. Nerves surrounding vessels traveling to and from the pancreas might also be inactivated leading to improvements in glucose tolerance and diabetes.

FIG. 22 depicts treatment 9200 of venous disease using the system described above. A blood vessel such as saphenous vein 9210 with a varicosity is instrumented with a catheter 9230. In some embodiments, ultrasound such as Doppler ultrasound 9240 is used to target the saphenous vein 9210. Focused ultrasound 9220 can be applied from outside the skin of the patient through the skin of the patient and to the varicosity 9215. The catheter creates a center point for a treatment plan and focused ultrasound is then applied around the vein which contains the catheter. The focused ultrasound damages the vein enough to create a healing response which closes the vein to blood flow and prevents further progression of the venous disease. In some embodiments, the venous blood flow is stopped during the treatment so as to allow the heat to build up around and on the vein.

FIG. 23 depicts treatment of diseases 9400 such as atrial fibrillation of other arrhythmias of the heart. A catheter 9405 is placed inside one of the chambers 9415. Lesions 9410 are produced from an external energy source 9420 which delivers energy through the chest wall and to the heart muscle wall. Heat and energy applied to the wall ultimately inhibit or prevent nerve conduction of erratic arrhythmias in the heart muscles.

FIG. 24 depicts a feedback algorithm to treat the nerves of the autonomic nervous system. It is important that there be an assessment of the response to the treatment afterward. Therefore, in a first step, modulation of the renal nerves 9400 is accomplished by any or several of the embodiments discussed above. An assessment 9410 then ensues, the assessment determining the degree of treatment effect engendered; if a complete or satisfactory response is determined 9420, then treatment is completed. For example, the assessment 9410 might include determination through microneurography, assessment of the carotid sinus reactivity (described above), heart rate variability, measurement of norepinephrine levels, tilt test, blood pressure, ambulatory blood pressure measurements, etc. With a satisfactory autonomic response 9420, further treatment might not ensue or depending on the degree of response, additional treatments of the nerves 9430 may ensue to further reduce the autonomic activity in the patient. A map of position location versus response can also be created so that the nerves can essentially be mapped and specific zones of inhibition created.

FIG. 25 depicts a reconstruction of a patient 9500 from CT scan images showing the position of the kidneys 9520 looking through the skin of a patient 9500. The ribs 9510 partially cover the kidney but do reveal a window at the inferior pole 9530 of the kidney 9520. Analysis of many of these reconstructions has lead to clinical paradigm in which the ribs 9510, pelvis 9450, and the vertebra 9440 are identified on a patient, the kidneys are identified via ultrasound and then renal arteries are identified via Doppler ultrasound. A relevant clinical window may have an access angle of between 40 and 60 degrees with respect to a horizontal line, for example, a horizontal line defined by the two spinous processes.

As shown in FIG. 26a, once the ribs 9612 and vertebra 9614 are identified with the Doppler ultrasound, an external energy source 9600 can be applied to the region. Specifically, focused ultrasound (HIFU or LIFU) can be applied to the region once these structures are identified and a lesion applied to the blood vessels (renal artery and renal nerve) 9620 leading to the kidney 9610. As described herein, the position of the ultrasound transducer 9600 is optimized on the posterior of the patient as shown in FIG. 26A. That is, with the vertebra, the ribs, and the iliac crest bordering the region where the ultrasound is applied.

Based on the data above and specifically the CT scan anatomic information in FIG. 26A, FIG. 26B depicts a device and system 9650 designed for treatment of this region (blood vessels in the hilum of the kidney) in a patient. It contains a 0.5-3 Mhz ultrasound imaging transducer 9675 in its center and a cutout or attachment location of the ultrasound ceramic (e.g. PZT) for the diagnostic ultrasound placement. Although depicted within a cutout, the imaging device does not have to connected to the therapy device and the can have independent positioning and movements mechanisms. However, as described below, the imaging and therapy transducers need to know where each is relative to the other in space. The device also contains a movement mechanism 9660 to control the therapeutic transducer 9670. The diagnostic ultrasound device 9675 is coupled to the therapeutic device in a well-defined, known relationship. The relationship can be defined through rigid or semi-rigid coupling or it can be defined by electrical coupling such as through infrared, optical-mechanical coupling and/or electro-mechanical coupling. In some embodiments, potentiometers can be used, the potentiometers allowing for the exact position of the imaging device to be related to the therapy device. Along the edges of the outer rim of the device, smaller transducers 9670 can be placed which roughly identify tissues through which the ultrasound travels. For example, simple and inexpensive one or two-dimensional transducers might be used so as to determine the tissues through which the ultrasound passes on its way to the target can be used for the targeting and safety. From a safety perspective, such data is important so that the ultrasound does not hit bone or bowel and that the transducer is properly placed to target the region around the renal blood vessels. Also included in the system is a cooling system to transfer heat from the transducer to fluid running through the system. Cooling via this mechanism allows for cooling of the ultrasound transducer as well as the skin beneath the system. A further feature of the system is a sensor mechanism 9665 which is coupled to the system 9650 and records movement of the system 9650 relative to a baseline or a coordinate nearby. In one embodiment, a magnetic sensor is utilized in which the sensor can determine the orientation of the system relative to a magnetic sensor on the system. The sensor 9665 is rigidly coupled to the movement mechanism 9660 and the imaging transducer 9675. In addition to magnetic, the sensor might be optoelectric, acoustic, imaging (e.g. camera), or radiofrequency based. Knowledge of the movement of the system via the sensor allows an operator (or no operator) to track movement and couple this movement to the ultrasound therapy transducer such that the movement of the therapy transducer can result in a corresponding change in the position of the focused ultrasound from the therapeutic transducer. Therefore, in one embodiment, a coordinate reference of a therapeutic element relative to a target is determined by a coordinate sensor rigidly or semi-rigidly coupled to the therapeutic transducer. In one embodiment, an arm swivels off of the transducer, the arm containing an imaging probe (e.g. an ultrasound imaging probe), the arm tracked with an electromagnetic or optical tracking system. The tracking system computes the three dimensional position of the ultrasound image relative to the transducer position. Based on knowledge of the coordinates of each the therapy transducer can be directed to apply therapy at any spot indicated within the imaging window.

Furthermore, the face 9672 of the transducer 9670 is shaped such that it fits within the bony region described and depicted in FIG. 26A. For example, in some embodiments, the shape might be elliptical or aspheric; in other embodiments, the shape may be triangular or pie shaped; in a preferred embodiment, the membrane shape conforms to the patient by expanding into skin or other crevices of the patient. In addition, in some embodiments, the ultrasound imaging engine might not be directly in the center of the device and in fact might be superior to the center and closer to the superior border of the face of the transducer and closer to the ribs, wherein the renal artery is visualized better with the imaging probe 9675. The membrane may further contain a cooling liquid such as water which removes heat from the transducer and can also cool the skin. Within the membrane as well, there may be a camera through which the skin can be visualized during treatment. The camera may be infrared or an ultrasound based camera. An ultrasound based camera might enable distances to be determined, distances for example of the transducer face to the skin, or of the water within the membrane to determine volume.

Given the clinical data as well as the devised technologies described above (e.g. FIG. 26A-B), FIG. 27A illustrates the novel treatment plan 9700 to apply energy to the nerves around the renal artery with energy delivered from a position external to the patient.

In one embodiment, the patient is stabilized and/or positioned such that the renal artery and kidneys are optimally located 9710. Diagnostic ultrasound 9730 is applied to the region and optionally, ultrasound is applied from a second direction 9715. The positioning and imaging maneuvers allow the establishment of the location of the renal artery, the hilum, and the vein 9720. A test dose of therapeutic energy 9740 can be applied to the renal hilum region. In some embodiments, temperature 9735 can be measured. This test dose can be considered a full dose if the treatment is in fact effective by one or more measures. These measures might be blood pressure 9770, decrease in sympathetic outflow (as measured by microneurography 9765), increase in parasympathetic outflow, change in the caliber of the blood vessel 9755 or a decrease in the number of spontaneous spikes in a microneurographic analysis in a peripheral nerve (e.g. peroneal nerve) 9765, or an MRI or CT scan which reveals a change in the nervous anatomy 9760. In some embodiments, indices within the kidney are utilized for feedback. For example, the resistive index, a measure of the vasoconstriction in the kidney measured by doppler ultrasound is a useful index related to the renal nerve activity; for example, when there is greater autonomic activity, the resistive index increases, and vice versa.

Completion of the treatment 9745 might occur when the blood pressure reaches a target value 9770. In fact, this might never occur or it may occur only after several years of treatment. The blood pressure might continually be too high and multiple treatments may be applied over a period of years . . . the concept of dose fractionation.

Fractionation is a major advantage of applying energy from a region external to a region around the renal arteries in the patient as it is more convenient and less expensive when compared to invasive treatments such as stimulator implantation and interventional procedures such as catheterization of the renal artery.

FIG. 27B depicts a patch 9782 (27B) or cuff 9784 (27C) which might be worn by a patient 9780 during a procedure on his or her arm 9780. In one embodiment, FIG. 27B, the patch 9782 detect signals related to autonomic activity within the patient. During, before or after treatment, the degree of autonomic activity might be changed by the treatment and these changes can be detected through the patch. The patch might detect blood pressure, arrhythmias (irregular heartbeats), changes in autonomic relationships (for example, the relationship between sympathetic and parasympathetic signals).

Another important component is the establishment of the location and position of the renal artery, renal vein, and hilum of the kidney 9720. As discussed above, the utilization of Doppler ultrasound signaling allows for the position of the nerves to be well approximated such that the ultrasound can be applied to the general region of the nerves. The region of the nerves can be seen in FIGS. 29A-D. FIGS. 29A-C are sketches from actual histologic slices. The distances from the arterial wall can be seen at different locations and generally range from 0.3 mm to 10 mm from the wall of the artery. Nonetheless, these images are from actual renal arteries and nerves and are used so as to develop the treatment plan for the system. For example, once the arterial wall is localized 9730 using the Doppler or other ultrasound signal, a model of the position of the nerves can be established and the energy then targeted to that region to inhibit the activity of the nerves 9720. Notably, the distance of many of these nerves from the wall of the blood vessel indicate that a therapy which applies radiofrequency to the wall of the vessel from the inside of the vessel likely has great difficulty in reaching a majority of the nerves around the blood vessel wall.

For example, FIG. 29D depicts a schematic from a live human ultrasound. As can be seen, the ultrasound travels through skin, through the subcutaneous fat, through the muscle and optionally at least partially through the kidney 8935 to reach the hilum 8941 of the kidney and the renal blood vessels 8937. This direction was optimized through clinical experimentation so as to not include structures which tend to scatter ultrasound such as bone and lung. Experimentation lead to the optimization of this position for the imaging and therapy of the renal nerves. The position of the ultrasound is between the palpable bony landmarks on the posterior of the patient as described above and below. The vertebrae are medial, the ribs superior and the iliac crest inferior. Importantly, the distance of these structures 8943 is approximately 8-12 cm and not prohibitive from a technical standpoint. These images from the ultrasound are therefore consistent with the results from the CT scans described above as well.

FIG. 29E depicts the surface area 8760 available to an ultrasound transducer for two patients out of a clinical study. One patient was obese and the other thinner. Quantification of this surface area 8762 was obtained by the following methodology: 1) obtain CT scan; 2) mark off boundary of organs such as the vertebrae, iliac crest, and ribs; 3) draw line from renal blood vessels to the point along the edge of the bone; 4) draw perpendicular from edge bone to the surface of the skin; 5) map the collection of points obtained along the border of the bone. The surface area is the surface area between the points and the maximum diameter is the greatest distance between the bony borders. The collection of points obtained with this method delimits the area on the posterior of the patient which is available to the ultrasound transducer to either visualize or treat the region of the focal spot. By studying a series of patients, the range of surface areas was determined so as to assist in the design which will serve the majority of patients. The transducers modeled in FIG. 30 have surface areas of approximately 11×8 cm or 88 cm²which is well within the surface area 8762 shown in FIG. 29E, which is representative of a patient series. Furthermore the length, or distance, from the renal artery to the skin was quantified in shortest ray 8764 and longest ray 8766. Along with the angular data presented above, these data enable design of an appropriate transducer to achieve autonomic modulation and control of blood pressure.

In a separate study, it was shown that these nerves could be inhibited using ultrasound applied externally with the parameters and devices described herein. Pathologic analysis revealed that the nerves around the artery were completely inhibited and degenerated, confirming the ability of the treatment plan to inhibit these nerves and ultimately to treat diseases such as hypertension. Furthermore, utilizing these parameters, did not cause any damage within the path of the ultrasound through the kidney and to the renal hilum.

Importantly, it has also been discovered via clinical trials that when ultrasound is used as the energy applied externally, that centering the diagnostic ultrasound probe such that a cross section of the kidney is visualized and the vessels are visualized, is an important component of delivering the therapy to the correct position along the blood vessels. One of the first steps in the algorithm 9700 is to stabilize the patient in a patient stabilizer custom built to deliver energy to the region of the renal arteries. After stabilization of the patient, diagnostic ultrasound is applied to the region 9730 to establish the extent of the ribs, vertebrae, and pelvis location. Palpation of the bony landmarks also allows for the demarcation of the treatment zone of interest. The external ultrasound system is then placed within these regions so as to avoid bone. Then, by ensuring that a portion of the external energy is delivered across the kidney (for example, using ultrasound for visualization), the possibility of hitting bowel is all but eliminated. The ultrasound image in FIG. 29D depicts a soft tissue path from outside the patient to the renal hilum inside the patient. The distance is approximately 8-16 cm. Once the patient is positioned, a cushion 9815 is placed under the patient. In one embodiment, the cushion 9815 is simply a way to prop up the back of the patient. In another embodiment, the cushion 9815 is an expandable device in which expansion of the device is adjustable for the individual patient. The expandable component 9815 allows for compression of the retroperitoneum (where the kidney resides) to slow down or dampen movement of the kidney and maintain its position for treatment with the energy source or ultrasound. In another embodiment, the adjustments are automated where a sensor on each expandable component senses a variable such as pressure, and the device automatically performs the adjustments based on the sensed variable (e.g., when the pressure exceeds or is below a pre-determined threshold).

A test dose of energy 9740 can be given to the region of the kidney hilum or renal artery and temperature imaging 9735, constriction of blood vessels 9755, CT scans 9760, microneurography 9765 patch or electrode, and even blood pressure 9770. Thereafter, the treatment can be completed 9745. Completion might occur minutes, hours, days, or years later depending on the parameter being measured.

A patch can be worn by the patient prior to and/or after treatment to indicate the level of sympathetic activity within the patient. The patch might detect EMG signals (e.g. from muscle) or direct nervous system signals. The patch might also detect heart rate variability in some embodiments.

Through experimentation, it has been determined that the region of the renal hilum and kidneys can be stabilized utilizing gravity with local application of force to the region of the abdomen below the ribs and above the renal pelvis. For example, FIGS. 28A-C depict examples of patient positioners intended to treat the region of the renal blood vessels.

FIG. 28A is one example of a patient positioned in which the ultrasound diagnostic and therapeutic 9820 is placed underneath the patient. The positioner 9810 is in the form of a tiltable bed. A patient elevator 9815 placed under the patient pushes the renal hilum closer to the skin and can be pushed forward in this manner; as determined in clinical trials, the renal artery is approximately 2-3 cm more superficial in this type of arrangement with a range of approximately 7-15 cm in the patients studied within the clinical trial. The weight of the patient allows for some stabilization of the respiratory motion which would otherwise occur; the patient elevator can be localized to one side or another depending on the region to be treated. Alternative approaches (in the case where the physician wants to maintain the patient in a flat position) are to place a positioning device under the patient's legs and maintain the upper torso substantially flat. The therapeutic transducer 9820 is placed between the bony regions of the backside of the patient, namely the ribs superior, the spinous processes medially, and the pelvis inferiorly. This positioning allows access to the region of the renal arteries or the renal hilum of the patient. The renal hilum includes the renal artery, the renal vein, the renal pelvis, and the ureters.

FIG. 28B detects a more detailed configuration of the ultrasound imaging and therapy engine 9820 inset. A patient interface 9815 is utilized to create a smooth transition for the ultrasound waves to travel through the skin and to the kidneys for treatment. The interface is adjustable such that it is customizable for each patient. The interface is typically filled with a fluid through which ultrasound easily flows (for example, deionized and degassed water). In some embodiments, a fluid management system is utilized to control one or more parameters of the fluid inside the membrane which couples to the patient. For example, the pressure of the fluid inside the membrane may be controlled by a pressure sensor and closed loop feedback system to maintain a pre-specified pressure against the skin of the patient. The temperature of the fluid inside the membrane may also be monitored and controlled. For example, the temperature may be controlled to 10 degrees C., 15 degrees C., 20 degrees C., or 25 degrees C. so as to cool the transducer and/or the skin. Within the patient interface 9815, tools such as a camera to visualize body placement of the patient. The camera might be optical, allowing for visualization through the membrane, or the camera might provide infrared information to for example, monitor heating of the skin. As proven through clinical work, the visualization allows for removal of bubbles prior to treatment. The bubbles can potentially reflect ultrasound waves and distort the treatment pattern. Therefore, the ability to remove bubbles and add diagnostic ability to the membrane is important to insure a safe treatment with focused ultrasound. The camera might also be, in addition to, or in place of, an ultrasonic generator which sends ultrasonic echos at low diagnostic levels to determine the distance to one or more structures along the path. Such distance mapping allows for more specific modeling of the tissues the therapeutic ultrasound must traverse to reach the target such as a renal nerve. An ultrasonic imager might also determine the distance of a water path through which the therapeutic ultrasound travels before traversing the skin to the target region.

FIG. 28C depicts another embodiment of a positioner device 9850, this time meant for the patient to be face down. In this embodiment, the patient is positioned in the prone position lying over the patient elevator 9815. Again, through clinical experimentation, it was determined that the prone position with the positioner under the patient pushes the renal hilum posterior and stretches out the renal artery and vein allowing them to be more visible to ultrasound and accessible to energy deposition in the region. The positioner underneath the patient might be an expandable bladder with one or more compartments which allows for adjustability in the amount of pressure applied to the underside of the patient. The positioner might also have a back side which is expandable 9825 and can push against the posterior side of the patient toward the expandable front side of the positioner thereby compressing the stretched out renal blood vessels to allow for a more superficial and easier application of the energy device. These data can be seen in FIGS. 7G and 7H where the renal artery is quite a bit closer to the skin (7-17 cm down to 6-10 cm). The position of the energy devices for the left side 9827 of the patient and right side 9828 of the patient are depicted in FIG. 28C. The ribs 9829 delimit the upper region of the device placement and the iliac crest 9831 delimits the lower region of the device placement. The spinous processes 9832 delimit the medial edge of the region where the device can be placed and the region between 9828 is the location where the therapeutic transducer is placed.

FIGS. 28D-28E depict a system implementation of the description above. Belt 9853 is fixed to the transducer 9855. Bladder 9857 is an adaptable and fillable cavity which can be used to help stabilize the flank region of the patient by pressing the posterior skin against the belt and transducer 9855. The transducer incorporates many of the embodiments described herein. For example, in the illustrated embodiments, the transducer is designed and manufactured with such a specification that it applies energy directed to the region of the renal artery and nerves. The transducer may be shaped like a pizza slice with annular components, or multiple elements forming into a global shape, like a pizza slice (as described herein). The transducer may also provide imaging and motion tracking capability such as with a pulse-echo detection system or with integral ultrasound imaging. The imaging aid might detect an indwelling vascular catheter or an implant. Nonetheless, the imaging aid can both detect the target track its motion. The therapeutic aspect of the transducer 9855 may generate focused ultrasound at a frequency of 0.5 MHz to 3 MHz depending on the specific configuration or pattern desired. Monitor 9862 is utilized to monitor the progress of the therapy throughout the treatment regimen.

Thus, in one embodiment of the system, as depicted in FIGS. 28D and 28E, the system comprises a belt which circumscribes the patient and applies a bladder (optionally) on one side of the patient to limit excursion of the abdominal organs and at least partially stabilize the abdominal organs, such as the kidney. Additionally, imaging and tracking may be utilized to maintain the positioning of the therapeutic energy focus. The stabilized focused energy system can then be automatically directed (e.g., by a processor) to track and follow the blood vessels and carry out a treatment according to a treatment plan, e.g., to treat tissue (nerves) surround the vessels leading to the kidney. The bladders may be filled automatically. In some cases, motion controllers may be utilized to direct the therapeutic energy focus to regions close to or within the hilum of the kidney.

FIGS. 28E-G depict a more complete picture of the transducer to be applied to the back of the patient 9855 within the belt 9853FIG. 28F depicts a 6 dimensional movement mechanism for the transducer platform with a positionable arm and its fit into the system configuration 9860. Six degrees of freedom are available for movement, which includes rotation and translation of the transducer. The platform is able to move in 6 degrees of freedom and the bottom mover allows for the transducer to be pressed against the skin of the patient.

FIG. 28H depicts a patient treatment system 9800 in which a catheter 9805 is inserted into the patient 9810 and the system 9820 is placed behind the patient. Coupling applicator 9815 is pressed against the patient to maintain coupling contact between the therapeutic system 9820 and the patient. Catheter 9805 can be utilized to assist in targeting of the blood vessels and nerves being treated by the therapeutic system. Maintaining the therapeutic system 9820 behind the patient allows the patient's weight to be utilized in maintaining coupling between the system 9820 and patient 9810. The catheter 9805 preferably is in the form of one of the embodiments above, and may be used for targeting or directing an external treatment. Alternatively, the catheter 9805 may be used as a primary therapy in combination with external imaging (diagnostic). The system 9820 is placed behind the patient and optionally contains a multi-element ultrasound transducer array along with a mechanical movement system to position the array.

FIG. 28I is a close up picture of the transducer 9820. Elements 9809 are depicted with different phasing patterns and cartesian coordinate positions to meet at the intersection 9807. Elements 9809 can also translate or rotate within the transducer allowing for a multi-modality therapy. Inside of the transducer 9820, the therapeutic piezoelectric array might be of an annular type, a bowl type, or a multi-element phased (2D) array. With any of the arrays, the array and any of its elements may communicate with the catheter to characterize the tissue treatment path, the positioning, and the targeting of the ultrasound energy.

FIG. 28J depicts a component 9865 to apply pressure to specific anatomic regions of the patient. Individual bladders 9860 can be inflated 9860 or deflated 9863 depending on the region of the patient for which pressure is applied. Such a system aids with conforming the applicator to the patient. In FIG. 28K, another configuration of a system to apply therapeutic energy to the region of the renal hilum is depicted. Transducer 9875 is depicted on the portion of the table which is positioned under the patient to be treated. Angiogram 9874 is visible in the case where a catheter is utilized for targeting. Therefore in one embodiment, the system to apply energy to the renal artery region is described in which a typical OR (operating room) or cath lab table is retrofitted for a therapeutic ultrasound underneath the patient. The therapeutic ultrasound array contains a movement mechanism to maintain the array in contact with the skin of the patient, wherein the mechanism is able to translate to the left side of the patient or the right side of the patient. The movement mechanism can operate (e.g., to track a target) based on an image (e.g., a doppler image) of a blood vessel.

FIG. 28K depicts the movement mechanism 9875 within a table 9870 to treat a patient who is positioned in the supine position. The table elevation is on the front side of the patient, pushing upward toward the renal hilum and kidneys. The head of the table may be dropped or elevated so as to allow specific positioning positions. The elevated portion may contain an inflatable structure which controllably applies pressure to one side or another of the torso, head, or pelvis of the patient. One or more wedges might be placed underneath the patient's knees to open up the small of their back to expose the kidney and blood vessels leading to the kidney and associated renal nerves. Monitors 9874 and 9875 may be utilized by the physician to visualize the position of the catheter. The bed 9876 is compatible with CT scan or fluoroscopy so that the position of the catheter may be determined with respect to the blood vessel regions to be treated.

FIG. 28L depicts a close-up and detailed mechanism for the transducer mover placed strategically underneath the patient (e.g. inside the patient bed). Outer housing 9884 allows for inner housing 9885 to rotate within, allowing for multiple axes of direction toward the patient and hence many different angles toward the target of interest (for example, the renal nerves surrounding the renal artery at the junction). Table 9886 has a recess for the transducer 9887 and ball in socket mover mechanism 9885. This “ball in socket” housing allows for positioning of the transducer 9887 on the back of a patient. The mechanism can rotate between −30 (and up to −50 degrees) and +30 degrees (and up to +50 degrees) relative to the normal position and central line through its axis 9883. Movement of the ball 9885 and socket 9884 can be automated or manual. For example, a motorized rack and pinion type arrangement may be attached to the ball and socket movement mechanism. In the illustrated example, the axis 9882 depicts the transducer 9887 when angled relative to its center. In another embodiment, transducer 9887 moves along line 9882 to place pressure against the patient in the angles which are locked in by the ball and socket mover mechanism 9884. Movement along axis 9882 may be automated with a controlled feedback system to maintain the pressure against the transducer and maintain contact with the patient on the table 9886. The top of the transducer assembly may be anywhere from 4 inches to as many as 13 inches above the top of the bed whereon the assembly sits. Another component of this transducer movement mechanism is its ability to move along its bottom surface so that the entire ball and joint mechanism is translated, for example, along a flat surface on the bed.

FIG. 28M depicts an embodiment in which a two dimensional phased array 9952 is placed on a patient 9960 on a table 9956. A flexible phased array 9952 within a belt is placed on the patient 9960 and secured within the belt type arrangement. This low profile focused ultrasound system may be placed on a catheterization or MRI/CT scan table, a fluoroscopy table, or an operative table rather than the belt arrangement. Alternatively, it may be recessed within a bed so that a patient lies over top of the transducer. A water cushion may be incorporated on top of the two dimensional phased array 9952 as well. The design of this embodiment arose from industrial design and clinical research in which the angles of approach to the renal artery region were analyzed to determine that the posterior approach to the renal blood vessels and nerves is an optimal approach for ablation of these nerves to treat hypertension.

FIG. 28N depicts another embodiment of a two dimensional array used to heat autonomic nerves surrounding a blood vessel leading to a kidney. A water pillow 9974 is shown as an integral part of the table 9956. The two dimensional array 9970 is built into the table beneath the water pillow 9974. A patient then is placed on the table and on the water pillow. Ultrasound is then subsequently delivered from the array 9970 through the water pillow 9974 to the autonomic nerves surrounding the blood vessel leading to the kidney. In this embodiment, there is no mechanical mover. Rather, the beam focus is moved with electronic phasing of the individual elements, each element capable of creating a variable phase, the summation of which is capable of being focused at different points within a treatment volume.

FIG. 29A-C depicts the anatomical basis 9900 of the targeting approach described herein. These figures are derived directly from histologic slides. Nerves 9910 can be seen in a position around renal artery 9920 and vein 9922 (FIG. 29C). The range of radial distance from the artery is out to 2 mm and even out to 10 mm. Importantly, this figure reveals the distance of many of the nerves actually reach out to the vein 9912. The ultrasound treatment described herein allows for treatment of these nerves out to the vein in human patients. Anatomic correlation with the modeling in FIG. 16B reveals the feasibility of the targeting and validates the approach based on actual pathology; that is, the approach of applying therapy to the renal nerves by targeting the adventitia of the artery, and using the kidney as both a conduit and fiducial for the focused energy (e.g., focused ultrasound energy). This is important because the methodology used to target the nerves is one of detecting the Doppler signal from the artery and then targeting the vessel wall around the doppler signal. Nerves 9910 can be seen surrounding the renal artery 9920 which puts them squarely into the temperature field shown in 16B indicating the feasibility of the outlined targeting approach in FIG. 27 and the lesion configuration in FIG. 16A. Further experimentation (utilizing similar types of pathology as well as levels of norepinephrine in the kidney) reveals that the required dose of ultrasound to the region to affect changes in the nerves is on the order of 100 W/cm²for partial inhibition of the nerves and 1-2 kW/cm²for complete inhibition and necrosis of the nerves. These doses or doses in between them might be chosen depending on the degree of nerve inhibition desired in the treatment plan. Importantly, it was further discovered through the experimentation that an acoustic plane through the blood vessels was adequate to partially or completely inhibit the nerves in the region. That is to say, that a plane through which the blood vessels travels perpendicularly is adequate to ablate the nerves around the artery as illustrated in FIG. 16B. Until this experimentation, there had been no evidence that ultrasound would be able to inhibit nerves surrounding an artery by applying a plane of ultrasound through the blood vessel. Indeed, it was proven that a plane of ultrasound essentially could circumferentially inhibit the nerves around the blood vessel with no pathologic effect on the blood vessel wall itself.

FIG. 29D depicts a treatment combining the technical factors described herein. An ultrasound image with a doppler is shown with a blood vessel 8941 leading to a kidney 8935. The blood vessel (doppler signal and image) is targeted 8937 in three dimensions and the kidney 8935 is used as a conduit to conduct the focused energy (in this case ultrasound) toward the blood vessel. The kidney is further used as a fiducial, which indicates the direction, and indicates that the correct vessel is indeed targeted. A treatment paradigm is created in which a program is generated to move the focal plane around the target in three dimensions. Data generated, both theoretically and in pre-clinical models, reveals that the kidney indeed can be used as a conduit to conduct HIFU energy because the ability of the kidney to transmit ultrasound without heating is outstanding due to its high blood flow. Therefore, one preferred embodiment is that the kidney is utilized as a fiducial to direct the focused ultrasound, as well as allowing transmission through to the blood vessels of the kidney. In this embodiment, a kidney is located and its hilum position 8935 then located as well. Next, a planning step is determined in which the depth 8943 of the ultrasound may be determined, and focused or unfocused ultrasound is then delivered to the artery 8941 or vein 8937 leading to the kidney. In some embodiments, the planning of such treatment may be performed with the kidney in view.

FIGS. 30A-I depict three dimensional simulations from a set of CT scans from the patient model shown in FIG. 26A. Numerical simulations were performed in three dimensions with actual human anatomy from the CT scans. The same CT scans utilized to produce FIGS. 7E, 19, and 25 were utilized to simulate a theoretical treatment of the renal artery region considering the anatomy of a real patient. Utilizing the doses shown in the experimentation above (FIGS. 29A-D) combined with the human anatomy from the CT scans, it is shown with these simulations that the ability exists to apply therapeutic ultrasound to the renal hilum from a position outside the patient. In combination with FIG. 29, which as discussed, depicts the position of the nerves around the blood vessels as well as the position of the vessels in an ultrasound, FIG. 30A-I depicts the feasibility of an ultrasound transducer which is configured to apply the required energy to the region of the hilum of the kidney without damaging intervening structures. These simulations are in fact confirmation for the proof of concept for this therapy and incorporate the knowledge obtained from the pathology, human CT scans, human ultrasound scans, and the system designs presented previously above.

In one embodiment, FIG. 30A, the maximum intensity is reached at the focus 10010 is approximately 186 W/cm²with a transducer 10000 design at 750 MHz; the transducer is approximately 11×8 cm with a central portion 10050 for an ultrasound imaging engine. The input wattage to the transducer is approximately 120 W-150 W depending on the specific patient anatomy. The input voltage might be as high as 1000 W depending on the desired peak intensity at the focus. For example, for a peak intensity of 2 kW/cm², it may be desirable to have an input wattage of approximately 600-800 W.

FIGS. 30B and 30C depict the acoustic focus 10020, 10030 at a depth of approximately 9-11 cm and in two dimensions. Importantly, the region (tissues such as kidney, ureter, skin, muscle) proximal (10040 and 10041) to the focus 10020, 10030 do not have any significant acoustic power absorption indicating that the treatment can be applied safely to the renal artery region through these tissues as described above. Importantly, the intervening tissues are not injured in this simulation indicating the feasibility of this treatment paradigm. Transducer 10000 is shown and is a fixed focus transducer with a cut out 10050 for a diagnostic imaging transducer.

FIGS. 30D-F depict a simulation with a transducer 10055 having a frequency of approximately 1 MHz. With this frequency, the focal spot 10070, 10040, 10050 size is a bit smaller (approximately 2 cm by 0.5 cm) and the maximum power higher at the focus, approximately 400 W/cm²than shown in FIGS. 30A-C. In the human simulation, this is close to an optimal response and dictates the design parameters for the externally placed devices. The transducer in this design is a rectangular type of design (spherical with the edges shaved off) so as to optimize the working space in between the posterior ribs of the patient and the superior portion of the iliac crest of the patient. Its size is approximately 11 cm×8 cm which as described above and below is well within the space between the bony landmarks of the back of the patient.

FIGS. 30G-I depict a simulation with similar ultrasound variables as seen in FIGS. 30D-F. The difference is that the transducer 10090 was left as spherical with a central cutout rather than rectangular with a central cutout. The spherical transducer setup 10090 allows for a greater concentration of energy at the focus 1075 due to the increased surface area of vibratory energy. Indeed, the maximum energy from this transducer (FIG. 30H) is approximately 744 W/cm²whereas for the transducer in FIG. 30d, the maximum intensity is approximately 370 W/cm². FIG. 30H depicts one plane of the model and 30I another plane. Focus 10080, 10085 is depicted with intervening regions 10082 and 10083 free from acoustic power and heat generation, similar to FIG. 30A-F.

These simulations confirm the feasibility of a therapeutic treatment of the renal sympathetic nerves from the outside without damage to intervening tissues or structures such as bone, bowel, and lung. Hypertension is one clinical application of this therapy. A transducer with an imaging unit within is utilized to apply focused ultrasound to a renal nerve surrounding a renal artery. Both the afferent nerves and efferent nerves are affected by this therapy.

Other transducer configurations are possible. Although a single therapeutic transducer is shown in FIG. 30A-I, configurations such as phased array therapy transducers (more than one independently controlled therapeutic transducer) are possible. Such transducers allow more specific tailoring to the individual patient. For example, a larger transducer might be utilized with 2, 3, 4 or greater than 4 transducers. Individual transducers might be turned on or off depending on the patients anatomy. For example, a transducer which would cover a rib in an individual patient might be turned off during the therapy.

Although the central space is shown in the center of the transducer in FIGS. 30A-I, the imaging transducer might be placed anywhere within the field as long as its position is well known relative to the therapy transducers. For example, insofar as the transducer for therapy is coupled to the imaging transducer spatially in three dimensional space and this relationship is always known, the imaging transducer can be in any orientation relative to the therapeutic transducer.

Another embodiment of a customized transducer 11030 is depicted in FIGS. 30J-30K. Importantly, this transducer is specifically designed to accommodate the anatomy shown above for the kidney anatomy. The pizza slice shape 11000 is unique to treat the anatomy in which the ribs, spine and pelvis are considered. Sensors 11040 are located along the edges of the transducer and allow for imaging or otherwise to detect the direction of the ultrasound system as it travels through the patient toward its target. At the tip of the system, 11010, 11050, an ultrasound imaging probe is included where the probe is coupled to the therapeutic ultrasound array 11030 and 11020. The number of elements 11030 determines the spatial resolution of the array and the degree to which the focus can be electronically controlled. Imaging array at position toward the apex of the array 11010, 11050 can be optimized for the anatomy in the region of the renal artery to directly image the artery and surrounding anatomy. With this location, the imaging array can be linked to the therapy portion of the array to provide image guided therapy to the autonomic nerves surrounding the renal blood vessels.

The sensors around the side 11040 may be small 1D imaging transducers or contain a single plane. Alternatively, they may be acoustic time of flight sensors for measuring the distance to the target or a combination of the two different techniques.

FIGS. 30L-N depicts additional views of the transducer 11095, 11075, 11090, in which the imaging component is in the center 11070, side cutout 11075, and within the pie slice shape 11085. The pizza slice shape 11080 does not necessarily have to be shaped as a slice but might be a larger array in which a slice shape is produced by turning on or off any number of transducers. The transducers in such an embodiment 11120 can have square, annular, or rectangular elements each of which has its own controller for imaging or therapeutic uses.

FIG. 30O-Q depicts a transducer 11140 with several elements arranged into a fixed focus 11130. Each of the 6 elements 11150 can be tuned to focus on a spot a given focal length from the transducer. The pizza slice shape can be fit into the region between the ribs and spine and the pelvis to apply therapy to a blood vessel such as the renal artery or the renal vein. FIG. 30Q depicts discreet movers 11141, 11143, 11145 which dictate the degree of overlap at the focus 11147.

FIG. 30R-S depicts a transducer 11200 with many elements 11230. Again, although shaped like a slice of a pie 11220, the shape can be created by turning on transducers from a larger cutout. A cross section 11210 is shown as well (FIG. 30R) revealing a thickness of the array 11220 which can range from several mm to a few cm. The profile is produced such that the transducer can be adapted to fit into the acoustic window of a human patient with anatomy described herein.

FIG. 30V is an expanded version of a transducer 11300 in which discrete bowls are fit together to simulate a larger bowl 11310 approximation. In this arrangement, the individual bowls 11324, 11320, 11322, 11324, 11326 each provide a piece of the curvature of a larger bowl, which would otherwise be very difficult to manufacture. Housing 11330, 11340 further combine with the bowls to create a transducer composite.

FIG. 30W depicts the assembly of the configuration 11350 with the bowls in combination which when powered, creates a single focus 11355. By moving each individual bowl slightly, the focus can be made to be elongate or circular.

FIGS. 30T-U depict simulations of the annular array transducers shown in FIGS. 30J-K. The simulation reveals that the focus can be electronically controlled between less than 10 cm 11512 distance 11510 to greater than 14 cm 11514 distance 11500. These distances are compatible with the blood vessels leading to the kidney in humans and are delivered from within the envelope of the window on the posterior portion of the patient's back.

FIG. 30V depicts an exploded view of an assembly of a transducer 11300. A base 11310 might contain a motion control system for x-y-z motion, and optionally a pivot for rotation of the ultrasound array. Array 11322 is comprised of one or more ultrasound emanating crystals 11324 with different curvatures 11326, 11320 to focus energy. Housing 11330 might contain a nosecone or other directional structure to direct the ultrasound energy to a focus. Covering 11340 is a coupling structure with an integral membrane to couple the ultrasound energy to the patient. The transducer 11322 might provide a combination of phasing and mechanical movement for its operation.

FIG. 31A depicts a perspective view of a transducer device customized for the anatomy of the blood vessels leading to the kidney. This design is based on the anatomic, biologic, and technical issues discovered and described above specific for the clinical treatment of nerves surrounding the blood vessels which travel to the kidney. Transducer 11650 has multiple elements and is also able to be pivoted and translated. The individual elements of the array can be phased so that different depths of foci can be achieved 11600, 11610 to treat regions around a blood vessel 11620. An imaging transducer 11710 is attached to, or integrated with, the device 11700. Although the ultrasound imaging transducer has been described, in other embodiments, MRI, CT, or fluoroscopy can also be linked to the system 11700. The imaging transducer is customized for the depth and anatomy presented by the blood vessel such as one traveling to the kidney. The device further contains elements described above such as a mover to move the entire device as a complete unit, motion tracking to track its global motion in three dimensional space, and a water circulation system to maintain the temperature of the skin and the transducer to acceptable levels. The transducer 11700, positioned at one position behind the patient can deliver foci to individual points surrounding a blood vessel, specifically the renal artery, the renal vein, the aorta, the vena cava, the portal vein, the celiac artery, and the mesenteric veins. The blood vessel position in three dimensions is determined by a Doppler signal reflected from the blood vessel or an intravascular fiducial which is either temporarily or permanently placed. Mechanical movement combined with phasing of the elements allows various positions 11610 to be targeted around the blood vessel 11620.

Angle 11652 is important to the anatomy which is being treated. It represents the envelope of the therapeutic beam and is incorporated into the design of the system. It is represented in one plane in this figure and would cover approximately 40 to 70 degrees in this figure which allows for a treatment depth of between 6 cm and 15 cm. For the short dimension (into the drawing), the angle (not shown) would be 35 to 65 degrees. The treatment depth may be desirably adjusted with different phasing from the transducer; however, the shape of the focus is not substantially affected. The position in X and Y may be adjusted using mechanical manipulation but can also be adjusted via phasing elements. Therefore, in one embodiment, an ultrasound transducer is described within which a multi-element array is disposed, the transducer devised to allow for electrical focusing of a focused ultrasound beam at an angle 11652 to the central axis of the transducer to move the beam focus in the direction perpendicular to the plane of the transducer but at an angle to the central axis of the transducer. The angle is customized for the anatomy being treated. For example, when treating a region such as the renal artery and nerve going to the kidney, the blood vessels are located at an angle from a plane of the skin when the transducer is place between the ribs, iliac crest, and spine (for example, see FIG. 31A, angle 11652, transducer 11650 is placed on the skin underneath the ribs, lateral to the spine and superior to the iliac crest). A mover may also be provided, which moves the transducer in the plane of the transducer and perpendicular to the central axis of the transducer.

FIG. 31B depicts another embodiment of a transducer 11700 designed to deliver focused ultrasound specifically to the region of the kidney and associated blood vessels 11770. The transducer has multiple small bowl shaped transducers 11720 fitted together for a deep focus 11740 of the ultrasound. The smaller bowl transducers 11720 are each movable utilizing a mechanical manipulator 11780 so as to create foci with different sizes at the target. A water cooling system is present as well 11730, which ensures that the skin and the transducers are maintained at a predetermined temperature. The variations in foci include elongated, spiral, and annular, each with different depths 11740. In this embodiment, imaging is a component of the transducers 11720. ATOF (acoustic time of flight) receivers 11710 can optionally receive signals from transducers 11750 on an indwelling vascular catheter 11760, which contains piezoelectric transducers capable of transmitting information through the patient to receivers 11710.

FIG. 31C depicts a two component mover mechanism (termed upper and lower movers) 11820 with a patient table 11800 to house the transducer arrangement and hold a patient. A mover 11850 is responsible for placing the transducer 11840 against the skin of the patient inside of the cutout 11830 within the table; clinical studies have shown that up to 50 pounds of pressure can be applied by the lower transducer to the skin of the patient to maintain coupling. The mover 11850 is also responsible for lowering the upper transducer 11840. The upper transducer 11840 is positioned at the angle and position required to treat a region such as the renal nerves around a renal blood vessel. Electronic focusing might be utilized for some components of the system, including the z 11842 direction which is the vertical direction through the central axis of the transducer and would generally be pointing in the direction in and out of the patient being treated. With electronic focusing, the distance can be automatically determined and calibrated relative to the transducer. In some embodiments, X and Y motions are altered electronically with various phasing patterns created through the transducer. In some embodiments, a combination of electronic phasing and mechanical movement is utilized to achieve the proper focusing and positioning of the system on the patient. The transducers being used for the therapeutic application of energy to the patient might also be utilized for detection of ultrasound signals which can be used for imaging detection. A separate imaging transducer can be utilized to augment the therapy transducer. For example, acoustic time of flight can be utilized or B mode or Doppler imaging can be utilized. Therefore, in one embodiment, the transducer is positioned at the proper angle to reach the renal blood vessels. The table 11800 supports the patient while the transducer rests within the recess 11830. Inside the recess 11830, the transducer can be positioned with respect to the blood vessel to be treated within the patient. The transducer can be moved automatically (i.e. robotically) or can be moved manually by the operator.

FIG. 31D depicts a system and subsystem 12000 overview of one configuration. A transducer belt 12010 can be applied to a patient, wherein the belt includes an applicator 12020 with transducer containing a membrane assembly, packaging, temperature sensors, and coupling attachments for coupling to the skin of the patient. Within the transducer assembly is a carveout for an imaging engine 12180, which can be an annular array for imaging in the same package as the therapy transducer, or it can be a separate array 12040 tuned for a different frequency specific for imaging. Within the transducer belt is a mover for the applicator, for example, a mover 12030 which can translate in X-Y-Z and rotate around a pivot to deliver an ultrasound focus to any position within a space around a blood vessel. Alternatively, in another embodiment, phased array transducers may be utilized in for treatment, imaging, or both. A cooling subsystem 12060 is a component of the system, wherein the cooling subsystem is configured to maintain the transducer 12050 and membrane temperature at a pre-specified level. An optional targeting catheter 12170 is included in the system, wherein the targeting catheter may be used in characterizing the energy being delivered from the focused ultrasound as well as in assisting and verifying the targeting accuracy of the imaging and the coupling of the imaging to the motion control 12030. The targeting catheter 12170 can also include sensors to determine the amount of energy applied to the vessel, the temperature of the vessel and surroundings, the acoustic power flux, and the degree of motion of the vessel during, before, or after treatment. A user interface is also included, the user interface comprising a track ball, a mouse, a touch screen, or a keyboard 12090 to allow user interaction with the system. The system is powered using power supplies 12150 which can be switched or non-switched depending on which subsystem is being activated at any given time. Another optional feature is phase aberration correction 12065 (PAC) which allows for correction o aberrations due to the tissue path both inhomogeneity in the tissue path as well distance to the target. The targeting catheter 12170 sends a signal to the therapeutic ultrasound transducer 12050 and the individual phases for each element of the therapeutic transducer is characterized relative to the transmission path to the transducer. With each element phase known and characterized, the phase aberration can be corrected (PAC) 12065.

FIGS. 30R and 30S depict the active shape of the transducer, and 30T and 30U depict the simulation of the focused ultrasound at the depth of treatment. The perspective view of the focus 11600 is shown in FIG. 31A and the annular transducer 11650 which delivers the ultrasound to a blood vessel 11620 and surrounding nerves 11610 is shown as well. An imaging array 11710 is included in the system 11700 as well. The transducer shape is optimized for delivery into the region of the renal nerve surrounding a renal artery. That is, the pie slice shape allows for transmission of focused energy to the region at the renal artery. Its annular array configuration allows electronic phasing to different depths.

FIG. 31E depicts another embodiment 12570 of the treatment system wherein an applicator 12500 is moveable via an angular pivot 12510 and handles 12520 on the outside of the transdcuer. A housing 12530 contains the therapeutic transducer 12540 which is moveable by mechanical manipulators inside the housing 12530. Importantly, the focal direction of the therapeutic energy 12535 is directed cranially and anteriorly from the transducer. Modeling and experimental results suggest that this angle of energy delivery is preferred for avoidance of structures such as bowel and rib. The mechanical manipulators allow for tracking of the blood vessel during respirations as well as active creation of a pattern around the blood vessel (FIG. 31F12660).

FIG. 31F depicts a more detailed view 12650 of the transducer 12600 and its many elements 12610 which make up the phased array delivering focused ultrasound energy to a renal blood vessel 12620 close to an aorta 12630. The phased array transducer, its associated movers, and the treatment plan are customized to deliver energy 12665 in a pattern 12660 surrounding a blood vessel 12620 where the focus is relatively unfocused over approximately 1-2 cm³; that is, 95% of the energy is delivered in a 1 cm³12660 radius volume as opposed to other indications or focused ultrasound (tumors or fibroids) where 90% of the energy (of each focal point lesion) is focused within a region <5 mm³. The unique shape and element pattern of the array allows a pattern optimized for treating a nerve bundle surrounding a blood vessel 12620. The pattern of heat and ablation circumscribes the blood vessel 12620 which might be a preferred method to ablate nerves around an artery because the nerves are wrapped up in a bundle around the blood vessel. Optionally located on the transducer 12600 are receivers 12615 which can act as sensors to assist in determining the position of the blood vessel so that focused ultrasound 12665 can be accurately applied to the region. In one embodiment, the receivers receive a signal from an intravascular catheter which sends an ultrasound signal through the skin of a patient to be received by these receivers. Once the signal is received, using a time of flight calculation through multiple signal receivers, the location of the transducer on the catheter can be localized to sub mm accuracy. Focused region 12665 can be moved around the blood vessel through movement of the transducer 12600.

FIGS. 31G-31H depict a close up of the transducer 12700 with receivers 12710 and piezoelectric elements 12720. The piezoelectric elements are typically therapeutic elements and in this embodiment are comprised in an arrangement of partial, but continuous, annuli. Receivers can be placed on the perimeter of the transducer or inside of the transducer (e.g. in the middle). It's important that there be at least three and that they be placed sufficiently far away so as to enable accurate determination of position of the internal fiducial. The receivers can be comprised of piezoelectric receivers or receivers of signals such as electromagnetic signals. There may be 3 or more of the receivers and they can placed anywhere within the therapeutics piezoelectric elements 12720. In this embodiment, the transducer has over 200 therapeutic elements 12720 on it, all of which are or can be individually controlled with different phases. In some embodiments the radial elements are further cut so that, even if in a radial, or partial annular pattern, there may be over 100 elements located along the radius within a single radius. In some embodiments, each of the piezoelectric elements 12720 has an arc shape (i.e., partially circular shape), such as a partial circular ring shape. In other embodiments, each of the piezoelectric elements 12720 may have a curvilinear shape that forms a partial loop/ring, and the partial loops/rings may partially surround a common point or region. In further embodiments, each of the piezoelectric elements 12720 may be in a form of a partial ring that has other shapes, such as a partial square ring, a partial rectangular ring, a partial triangular ring, a partial pentagon ring, etc. Also, in some embodiments, the partial rings of the respective piezoelectric elements 12720 all partially surround the same location (e.g., a point or a region), which may be located at or near (e.g., within 1 inch, and more preferably within 0.5 inch, and even more preferably within 0.25 inch from) an edge of the transducer 12700. The focal axis of the transducer 12700 may extend from such location, and may be perpendicular to a surface of the transducer 12700. In other embodiments, the location surrounded by the partial rings of the respective piezoelectric elements 12720 may be away from the edge of the transducer 12700 (e.g., near a center of the transducer 12700). Also, in some embodiments, the focal axis of the transducer 12700 may not coincide with the location surrounded by the partial rings of the piezoelectric elements 12720. In some embodiments, the focal axis may be anywhere within the top ⅓ portion of the transducer 12700 (as represented by the different dashed lines 12707). In other embodiments, the focal axis may be outside the boundary of the transducer 12700 and is offset from the transducer 12700 (as represented by another dashed line 12707). Also, in some embodiments, the focal axis may be anywhere within a circular region that is defined by a center surrounded by the partial rings and having a radius that is ⅓ or less of a height of the transducer 12700 (e.g., measured from a top edge of the transducer 12700). The focal axis 12707 of any of the above examples may be considered as being at or near an edge (e.g., the top edge) of the transducer 12700. Also, in some embodiments, the focal axis 12707 may be offset from a geometric center of the cross-sectional shape of the transducer 12700. The position of the focal axis 12707 may be adjusted based on phasing of the transducer elements in some embodiments. In some embodiments, the surface of the transducer 12720 is curved rather than flat which further increases the focusing ability of the transducer 12700. The phase control has been optimized to produce the relatively focused but not highly focused pattern 12665 (FIG. 31F); such a focus can be called a soft focus of focused ultrasonic energy. Although in some embodiments, each element is controlled, in other embodiments, the elements are electrically coupled together (in any arrangement) so that the number of required electrical inputs can be decreased. In this embodiment, the focus of the energy is along a line perpendicular to the acoustic center 12705 of the array, in this case at the apex of the array. In other embodiments, the acoustic focus is at the geometric center or along one side. For example, in one embodiment, the acoustic focus is at the top of the transducer tip closest to the smallest annuli of the array. In yet another embodiment, the array is not flat but has contour to it, which would be called a three dimensional array (two dimensional if flat). The three dimensional array might be curved upward or rounded.

FIG. 31H depicts a view of the therapeutic transducer and catheter based targeting emitter 12820, the signals 12800 of which can be received by either the therapeutic array elements 12830 or receivers 12840 specifically tuned to receive signals from the catheter 12820. The element on the catheter can be any of a variety of signaling elements such as for example, it can be one or more ultrasound generating piezoelectric elements of frequencies 0.5 Mhz to 5 Mhz, electromagnetic transmitters, radio transmitters, optical transmitters, reflectors/absorbers for x-ray, etc. Importantly, although the signal receive from the catheter is intended to enable its localization, once the three dimensional coordinate of the catheter is known, focused ultrasound can be applied to target any point within a sphere of several centimeters 12825 around the catheter. In this way, a pattern of focused ultrasound 12810 can be created around the blood vessel to fully de-innervate the blood vessel. Although the target region is within a sphere around the catheter, any pattern or no pattern can be created relative to the catheter. In one embodiment, a broad field of ultrasound is applied to the region with the catheter, using the catheter as a generalized target for the ultrasound field. The single broad field can be moved about the catheter so that it is spread out.

FIG. 31I depicts a phase aberration analysis of signals being received by the transducer 12830 from the signaling catheter 12820. As ultrasound traverses the tissues, three important factors come into play. The first is absorption along the tissue path and the other two are the direction of the wave propagation and the speed of the wave (speed of sound) in the tissues. The speed and direction are also affected by the angle of the wave propagation; to the extent the transducer is directed at an angle to the tissues, further aberrations will occur. The human body is heterogeneous in that different tissue conduct sound at different speeds. Ultrasonic waves also can change direction when they reach an interface of two different tissues. These deviations due to tissue heterogeneity result in aberrations of the waves as they travel to a focus deep within a patient. With a phased array transducer, phase correction can compensate for these aberrations and the focus enhanced. Furthermore, with the targeting catheter described herein (FIG. 31H), a pulse can sent from it and received by the therapeutic elements on the array. The graph 12855 in FIG. 31I depicts results of each element 12870 receiving a sound pulse from the catheter. The results in the graph 12855 are obtained with the catheter and therapeutic array in humans and in its treatment position as shown in FIG. 31E. The phase 12875 utilized for each element is depicted on the y axis. The data can also be simulated using the same numerical modeling techniques presented below. Line 12850 depicts the results of the simulation and line 12860 depicts the results of the actual data obtained when the catheter is placed inside the renal blood vessel in a human patient. The curves are quite close indicating that the simulations can be utilized to predict the required phase for each element and that the in-vivo check reveals the accuracy of the implemented phases. Furthermore, the actual phases 12860 can be fed back into the simulation to compare actual phase versus theoretical phase and the relative effect on treatment of the nerves surrounding the blood vessels.

FIG. 31J depicts the results of numerical modeling and simulation of the treatments 12900, indicating how the treatments are able to surround a blood vessel when positioned at multiple positions surrounding the blood vessel. For example, renal artery 12914 (cross section 12950) and nerves 12945 receive focused ultrasound (focusing depicted by line 12925) at focal points 12915 with resulting penumbra 12910. Focusing line 12925 can be moved to different positions in front or behind the blood vessel (shown here behind) relative to the position of the transducer behind the patient. The penumbra can also reach nerves 12940 along the aorta 12912, potentially creating a more thorough ablation zone for the renal and other autonomic nerves. Importantly, this simulation is performed with the treatment applicator in the position relative to the patient shown in FIG. 31E. The results of the simulation reveal that indeed a circumferential treatment around a blood vessel can be created from delivery from the posterior position on the patient with multiple lesions placed around the blood vessel.

FIG. 31K depicts an actual numerical simulation 13000 using the transducer customized for the anatomy of the renal artery which is shown in FIG. 31E-G. The anatomy and organ relationships are derived from actual CT scans of human patients and are placed in the graphical scale shown 13032, 13010. Lesion 13300 is shown within the renal nerve region surrounding the renal artery 13030. The simulation is based on anatomy from actual CT scans of human beings. The lesion represents the focused ultrasound at 6 Db which represents >70% of the maximum acoustic energy integrated over the volume. The simulation, including phase and acoustic velocity through tissue, is performed with the actual array depicted in FIGS. 31E-G. In addition, the simulations utilize predicted movement of the patient, blood vessel, transducer, etc. so as to account for the effect of this movement on the temperature and overall efficacy of the treatment. For example, 1 mm, 2 mm, 3 mm, 4 mm of movement can be built into the simulation. The organs shown include the kidney 13025, bowel 13150, and renal artery 13030. The distance in the lateral direction 13010 is shown which corresponds to the target point (0 mm shown in the graph). The depth on the y axis 13032 is shown in mm. The coordinates of the organs and blood vessels are derived from the CT scans of human beings. Lesion 13300 is the result of focused ultrasound over a specified time. The acoustic simulation results in a temperature increase 13300 at the focal region. Given time, the focused ultrasound waves lead to further increases in temperature and then to tissue damage . . . inhibition and/or ablation of nerve function. Further simulation of additional lesions in different positions and different on and off sequences leads to a treatment plan adequate for clinical use and shown below in FIGS. 31L-O. This simulation provides further theoretical proof that the transducer, as designed, will apply focused ultrasound energy from outside the body of the patient to the region of the renal nerves inside the body of the patient.

FIG. 31L depicts the results from norepinephrine analysis 13400 after treatment with the system. These norepinephrine levels 13430 are from the kidney and represent stimulation from the sympathetic nerves leading to the kidney. When the nerves are inhibited or ablated, the norepinephrine levels would be expected to fall as shown in the figure. The x axis 13420 represents increasing dose and the y axis 13410 represents percent of control, the control side not having received any treatment. As can be seen in the figure, a dose response exists between the delivered dose and the decrease in norepinephrine which is the expected result . . . that is . . . more energy, more effect on the nerve. These data reflect the success of the system, the model, and the techniques described above to inhibit the function of the nerves leading to the kidneys.

FIG. 31M depicts results from pathologic analysis 13510 of nerves 13530 treated with the focused ultrasound described in this invention. In this analysis, blood vessel 13600 is completely intact and surrounding tissues 13520 are free from necrosis or inflammatory responses yet the nerves 13530 are injured and presumably non-functional. Further analysis for tyrosine kinase reveals that these nerves are indeed functionally injured. Nerves 13530 are larger nerves and smaller nerves 13531 are shown as well. At lower doses, the larger nerves retain tyrosine kinase activity (indicating their continuing functioning) but at higher doses, all nerve fascicles are effected. These data indicate a dose response in that the larger nerves are more resistant to ultrasound at the lower doses which indicates that a differential effect may occur which can be advantageous in the treatment of hypertension. The biologic feasibility depicted in this figure represents proof that the designed treatment applies can apply focused energy to the regions of the renal artery without tissue necrosis. These data are the biologic correlate of the simulations above and represent feasibility of the proposed treatment. Importantly, there is circumferential damage to the nerves surrounding the vessel indicating that the treatment plan in which ultrasound energy is applied to surround the blood vessel is indeed functioning correctly.

FIG. 31N depicts the results of a simulation 13700 involving the transducer and anatomy of the renal nerve shown above. Isodose curves 13730 and 13740 depict 3 Db and 6 Db (respectively) acoustic fields surrounding the blood vessels 13720 and 13710, the result of numerical simulation of a single spot in a pattern of 10 or more spots, each spot representing an individual focal position of the focused ultrasound (FIG. 31O) and the axes 13760 represent distance in millimeters. The 3 or 6 Db isodoses are utilized to determine the characteristic dimension D in FIG. 31O. Simulations for different depths and different acoustic powers allow for a look up table to be created within the software and system processor so that inputs from the patient are entered into the software and a treatment plan can be created given specific patient characteristics such as depth to the blood vessel such as the renal artery or vein. Cross sectional imaging (CT scans) from an actual patient has been utilized to accurately simulate the anatomy (e.g. kidney 13750) in actual human patients through which the ultrasound travels to reach the hilum of the kidney 13750 where the renal nerves are located. Ultrasound from a transducer such as the one shown in FIGS. 31E and 31F can be utilized in the simulation to determine the power required from the unique transducer design to provide a specific dose to the blood vessels in the simulated treatment 13730 and 13740. In this example, the treatment depth is approximately 12 cm and the power applied from the transducer is approximately 320 acoustic watts to create an acoustic focus which will create the biologically effective treatment around the blood vessel. The data in this figure support the technical feasibility of the treatment as described above.

FIG. 31O depicts a pattern 14000 which the system creates to surround a vessel with focused ultrasound. The pattern is centered such that the blood vessel is in the center 14020 of the pattern. Lesion numbers 14030 depict the sequence position of each additional lesion. Although the circles depict a given center of the focus of the ultrasound from the position of the transducer, in reality the ultrasound focus extends for up to 5-10 mm on either side of the center of the circle, depending on which db level is defined Time in between lesions is variable and might be 1, 2, 5, 10, 20 or even 60 seconds. The treatment time can also be varied and can last from 1 s, 4 s, 6 s, 10 s, 20 s depending on the peak and average power desired for treatment. The number of lesions can also be varied. In FIG. 31O, 18 lesions are shown but a few number might be utilized. For example, in another embodiment, 10-14 lesions are utilized and the D (the characteristic dimension) might be 2-3 mm which makes 2.5 D 7-8 mm and the diameter of the entire treatment zone 14000 about 1.2-1.5 cm. Although FIG. 31O depicts lesions being created in alternating patterns across the vessel (that is, from one side to another), the lesions can also be produced sequentially around the vessel. Although the pattern is shown in two dimensions, each lesion might be in front of or behind the next or previous lesion . . . that is, the lesion is created as a volume and by a volume of focused ultrasound. For example, each lesion might be up to 1.0 cm in front of or behind the previous lesion. In this manner, complete coverage of the vessel (FIG. 31Q) is achieved. Distance D 14010 is the presumed width of each specific focused ultrasound lesion. For example, D might represent the 3, 6, or 12 Db width of each lesion; in a preferred embodiment, D is the 3 Db distance. In some examples, D might be 0.5 mm, 2 mm, 1.0 cm, or 2.0 cm. In a preferred embodiment, D is equal to 2-3 mm at 3 Db. D is determined by simulations which predict the coverage of the vessel. FIG. 31P depicts results from a clinical trial involving the preferred embodiments of the system described. After treatment of human patients with the system and inhibition of the nerves leading to the kidney, the blood pressure 14100 dropped from an average of 180 mm Hg 14110 to an average of 130 mm Hg 14120 for a change 14130 in blood pressure of approximately 50 mm Hg. Simulation results described above were utilized to perform the treatments which resulted in these data. For example, intensities of between 200 and 400 W/cm²were used for these treatments, the required input powers predicted by the simulations. In addition, on and off treatment times were determined with the simulations and applied to the clinical treatments, for example, 6 s on or 12 s on delivered in the pattern shown in FIG. 31O. Other on and off patterns include 1-2 min off times after 4-6 spots, each delivered for 10-12 s. These on and off times allow for sufficient cooling of the tissues in between treatments and represent the results of the simulations and clinical feedback during the actual treatments. The results depicted in this figure prove out the technology described herein . . . that focused ultrasound can be delivered from a position outside a patient and blood pressure decreased in a human patient. Further clinical data includes norepinephrine spillover from these patients which showed over a 35% drop in 11/17 blood vessels studied.

FIG. 31Q depicts a three dimensional 14200 view of the heating pattern once applied to the blood vessel. The pattern depicted indeed covers the vessel in the longitudinal direction as well as the radial direction. Importantly, the pattern allows for treatment of the nerves surrounding the vessel in any orientation relative to the transducer outside the patient and any orientation of the blood vessel. The pattern is created by the 3 Db acoustic simulation which results in broad and consistent coverage around the vessel. The pattern from 31O is applied in a simulation around and along the vessel and the resulting summation in the lengthwise direction 14200 is shown in FIG. 31Q. Acoustic energy 14210 covers the length of the vessel. As can be seen from this actual numerical simulation, the length of the treatment (at 3 Db) along the vessel is approximately 1-2 cm and the width of the treatment is approximately 1-2 cm (across the vessel). The area of treatment at 3 Db is over 1 cm³and is sufficient to cover a greater region of the nerves leading to the kidney than competing technologies which deliver the energy from inside the blood vessel. The inner portion of the heat cloud where the vessel resides is cooled by a high rate of blood flow inside the renal blood vessel. Therefore, in one preferred embodiment, a system to deliver focused ultrasound from outside a patient to a blood vessel inside a patient utilizes a therapeutic transducer which produces a pattern around a blood vessel which results in temperature rise in an annular or spherical pattern surrounding the blood vessel extending over 1 cm³and 1 cm in length along the blood vessel. A specific pattern of ultrasound foci spaced apart around the vessel results in a pattern around the vessel which can ablate the nerves in a thorough circumferential and lengthwise volume along the blood vessel independent of the orientation of the vessel. In some embodiments, the transducer has many ultrasound elements which can move to different foci by adjusting the relative phasing of each elements. In other embodiments, the transducer is moved into different positions mechanically. In yet another embodiment, the pattern is created by a combination of movement and ultrasound element phasing.

It should be noted that one or more functions described herein may be performed using a processor, which may be a part of the medical system. The processor may be a FPGA, an ASIC, a general purpose processor, a microprocessor, or any of other types of processor known in the art. In some embodiments, the processor may include multiple processing units configured to perform respective functions. Also, in some embodiments, the processor may be communicatively coupled to an energy delivering device (e.g., an ultrasound transducer, a radiofrequency device, a light emitter, etc.), and may be configured to control the energy delivering device so that the energy delivering device can deliver energy to desirable target regions in accordance with a treatment plan. The communicative coupling may be implemented using a wireless device, or one or more wires. In some embodiments, the processor may also be communicatively coupled to a position determining device (e.g., an imaging device, such as an ultrasound imager, a fluoroscopic device, a MRI, etc., a signal emitting device, such as a catheter with an active fiducial, etc.). During a medical procedure, the position determining device provides multiple input to the processor at different respective times, wherein the multiple input are indicative of a position of a vessel at the different respective times. The processor processes the input from the position determining device, and controls the energy delivering device in response thereto. In one implementation, the multiple input from the position determining device are processed by the processor to determine a position of a vessel at multiple times, wherein the position of the vessel determined by the processor is substantially real time position. The processor then controls the energy delivering device so that energy is delivered to one or more target regions that are next to (e.g., at a prescribed offset distance away from) the position of the vessel. In the case in which the energy delivering device is an ultrasound transducer, the processor may control the position (e.g., orientation) of the transducer and/or a phasing of the transducer elements of the transducer, so that the energy can be aimed at a desired target region.

Number	Date	Country
61696090	Aug 2012	US
61786313	Mar 2013	US
61377908	Aug 2010	US
61347375	May 2010	US
61256983	Oct 2009	US
61250857	Oct 2009	US
61261741	Nov 2009	US
61291359	Dec 2009	US
61303307	Feb 2010	US
61256983	Oct 2009	US
61250857	Oct 2009	US
61261741	Nov 2009	US
61291359	Dec 2009	US

	Number	Date	Country
Parent	13091116	Apr 2011	US
Child	14015331		US
Parent	13048830	Mar 2011	US
Child	13091116		US
Parent	12902133	Oct 2010	US
Child	13048830		US
Parent	12725450	Mar 2010	US
Child	12902133		US
Parent	12685655	Jan 2010	US
Child	12725450		US

NON-INVASIVE AUTONOMIC NERVOUS SYSTEM MODULATION

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