It is recommended that children should brush their teeth for at least 45-60 seconds, and adults for at least 90 to 120 seconds. Most people, especially children, do not brush their teeth for a sufficient period of time to obtain maximum benefit, and moreover have difficulty accurately estimating the time necessary to brush the teeth. Toothpaste formulations have been developed which comprise dissolvable films or microcapsules comprising pigment, which are designed to release the pigment after 30 to 120 seconds of brushing, providing a color change signal of adequate brushing. One problem with these formulations, however, is the tendency of the pigment to stain the bristles of the toothbrush. There is a need for improved formulations with reduced potential to stain the bristles, but still providing a clear signal upon adequate brushing.
Following systematic testing, varying different formulation components, we surprisingly found that an interaction exists between the polymer thickener (in this case Gantrez) and titanium dioxide (a common opaque white pigment) that drives the deposit of the colored (blue) pigment on the bristles. Unexpectedly, the lower the TiO2 level, the less the blue pigment appears to deposit on the bristles. Without being bound by theory, we hypothesize that this is driven by a charge (polarization) phenomena.
The invention thus provides a pigment system for a dentifrice, wherein the dentifrice comprises a pigment and titanium dioxide, wherein the level of titanium dioxide is 0.01-0.375% by weight of the dentifrice.
Further areas of applicability of the present invention will become apparent from the detailed description provided hereinafter. It should be understood that the detailed description and specific examples, while indicating the preferred embodiment of the invention, are intended for purposes of illustration only and are not intended to limit the scope of the invention.
The following description of the preferred embodiment(s) is merely exemplary in nature and is in no way intended to limit the invention, its application, or uses.
The invention thus provides, in a first embodiment, a dentifrice (Dentifrice 1) having a pigment system which comprises one or more pigments and titanium dioxide, wherein the level of titanium dioxide is 0.01-0.375% by weight of the dentifrice; for example:
The invention further provides a method of cleaning the teeth comprising brushing with a dentifrice having a pigment system which comprises (i) a dissolvable or disintegratable film comprising one or more releasable pigments which are released during brushing, and (ii) titanium dioxide, wherein the level of titanium dioxide is 0.01-0.375%, e.g., about 0.1% by weight of the dentifrice, e.g., any of Dentifrice 1, et seq., for example
Orally acceptable: The compositions of the invention are intended for topical use in the mouth, thus components for use in the present invention should be orally acceptable, that is, safe for topical use in the mouth, in the amounts and concentrations provided.
As used throughout, ranges are used as shorthand for describing each and every value that is within the range. Any value within the range can be selected as the terminus of the range. In addition, all references cited herein are hereby incorporated by referenced in their entireties. In the event of a conflict in a definition in the present disclosure and that of a cited reference, the present disclosure controls.
Unless otherwise specified, all percentages and amounts expressed herein and elsewhere in the specification should be understood to refer to percentages by weight. The amounts given are based on the active weight of the material.
Embodiments of the present invention are further described in the following examples. The examples are merely illustrative and do not in any way limit the scope of the invention as described and claimed.
In initial experiments wherein toothpaste was prepared by admixing dissolvable film flakes comprising Pigment Blue 15 in a modified commercial dentifrice base, the toothbrush bristles are stained blue following repeated use and release of the pigment. The amount of blue on the bristles is measured using Lab color space (a color-opponent space with dimension L for lightness and a and b for the color-opponent dimensions, based on nonlinearly compressed CIE XYZ color space coordinates).
Initial experiments are performed with a variety of formulations to determine the key formulation drivers of bristle staining. A Design of Experiments approach is utilized to refine and systematically optimize the formulation, focusing on three ingredients.
Twenty-five formulations were prepared, with variables within this framework, and are systematically assessed for performance and bristle staining. The formulations containing Gantrez (a copolymer of methyl vinyl ether and maleic anhydride), sodium lauryl sulfate (SLS) and titanium dioxide within the above ranges follow below in Table 1:
It is surprisingly found that an interaction exists between Gantrez (a copolymer of methyl vinyl ether and maleic anhydride) and titanium dioxide that can cause deposit of the blue pigment on the bristles. Unexpectedly, the lower the TiO2 level, the less the blue pigment appears to deposit on the bristles. It is hypothesized that deposition may be driven by a charge (polarization) phenomena.
An optimized formulation is prepared, based on this data in Table 2 below:
This formulation is tested for whether the toothbrush bristles are stained following use. Whereas the original formulation showed substantial bristle staining (ΔE>20), the optimized formulation, while providing a good color change upon brushing, showed very little bristle staining (ΔE<5).
As those skilled in the art will appreciate, numerous changes and modifications may be made to the embodiments described herein without departing from the spirit of the invention. It is intended that all such variations fall within the scope of the appended claims.
Filing Document | Filing Date | Country | Kind |
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PCT/US2012/071137 | 12/21/2012 | WO | 00 |