Non-woven fabric for biomedical application based on poly(ester-amide)s

Abstract

Electrospun biodegradable poly(ester-amide) fabric is especially suitable as a scaffold for tissue engineering and to incorporate drug for burn or wound healing treatment to accelerate healing, or to prevent tissue adhesion after surgery.

Description

Claims

1. A non-woven fabric consisting essentially of biodegradable electrospun poly(ester amide) for use for biomedical application, which is sterilizable and has an average fiber diameter ranging from 0.1 to 10.0 micrometer, a median pore size ranging from 0.1 to 100 micrometer, a surface area ranging from 10 to 300 m2/g, an average thickness ranging from 0.01 to 0.500 mm, a flexural rigidity ranging from 10 to 80 mg·cm, an average air permeability ranging from 10 to 100 ft3/min/ft2, an average water vapor transmission rate ranging from 200 to 500 g/m2/24 hr, a wettability contact angle ranging from 40 to 80 degrees, tensile stress property ranging from 0.01 to 0.10 kgf/mm2, tensile strain property ranging from 100 to 800%, Young's modulus ranging from 0.20 to 20.0 MPa and tensile toughness ranging from 0.50 to 3.0 MPa.

2. The non-woven fabric of claim 1 where the poly(ester-amide) is able to be solution electrospun.

3. The non-woven fabric of claim 2 where the poly(ester-amide) has a reduced viscosity ranging from 1.0 to 2.0 dL/g and is selected from the group consisting of one or more subunits A, and one or more subunits B, and combinations thereof, where the one or more subunits A have the structure

4. The non-woven fabric of claim 3 when seeded with NHEK cells show cell attachment and proliferation in a Calcein-AM assay.

5. The non-woven fabric of claim 4 where the polyester amide has the structure (I) where R1 is (CH2)8, R3 is

6. The non-woven fabric of claim 1 with drug or other agent that accelerates healing, matrixed therein.

7. The non-woven fabric of claim 1 where the pore size is tailored for the utility by variation of electrospinning conditions.

8. A method for making the non-woven fabric of claim 1 comprising solution electrospinning of poly(ester-amide) and varying thickness of the non-woven fabric and/or solution concentration and/or collection distance and/or voltage and/or fiber diameter to vary pore size.