Claims
- 1. A dihydropyridinelactone of the formula ##STR18## in which R represents chlorine, bromine, cyano or C.sub.1 -C.sub.3 -alkyl,
- R.sup.2 represents straight or branched C.sub.1 -C.sub.6 -alkyl which is optionally interrupted by oxygen,
- R.sup.3 represents C.sub.1 -C.sub.3 -alkyl, and
- R.sub.4 represents C.sub.1 -C.sub.3 -alkyl.
- 2. A dihydropyridinelactone according to claim 1, in which
- R represents chlorine, bromine or methyl,
- R.sup.2 represents C.sub.1 -C.sub.6 -alkyl which is optionally interrupted by oxygen,
- R.sup.3 represents methyl, and
- R.sup.4 represents C.sub.1 -C.sub.3 -alkyl.
- 3. A dihydropyridinelactone according to claim 2, in which
- R.sup.4 represents ethyl.
- 4. A compound according to claim 1, wherein such compound is ethyl 4-(2-chlorophenyl)-1-ethyl-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate of the formula ##STR19##
- 5. A compound according to claim 1, wherein such compound is isopropyl 4-(2-chlorophenyl)-1-ethyl-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate of the formula ##STR20##
- 6. A compound according to claim 1, wherein such compound is ethoxyethyl 4-(2-chlorphenyl)-1-ethyl-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate of the formula ##STR21##
- 7. A compound according to claim 1, wherein such compound is t-butyl 4-(2-chlorophenyl)-1-ethyl-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate of the formula ##STR22##
- 8. A compound according to claim 1, wherein such compound is isopropyl 4-(2-methylphenyl)-1-ethyl-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate of the formula ##STR23##
- 9. A compound according to claim 1, wherein such compound is isopropyl 4-(2-cyanophenyl)-1-ethyl-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate of the formula ##STR24##
- 10. A blood sugar lowering composition comprising a blood sugar lowering effective amount of a compound according to claim 1 in admixture with a diluent.
- 11. A unit dose of a composition according to claim 10 in the form of a tablet, capsule or ampule.
- 12. A method of lowering a patient's blood sugar level which comprises administering to such patient a blood sugar lowering effective amount of a compound according to claim 1.
- 13. The method according to claim 12, wherein such compound is:
- ethyl 4-(2-chlorophenyl)-1-ethyl-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate,
- isopropyl 4-(2-chlorophenyl)-1-ethyl-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate,
- ethoxyethyl 4-(2-chlorophenyl)-1-ethyl-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate,
- t-butyl 4-(2-chlorophenyl)-1-ethyl-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate,
- isopropyl 4-(2-methylphenyl)-1-ethyl-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate or
- isopropyl 4-(2-cyanophenyl)-1-ethyl-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3410645 |
Mar 1984 |
DEX |
|
Parent Case Info
This is a continuation of application Ser. No. 713,053, filed Mar. 18, 1985, now abandoned.
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Number |
Name |
Date |
Kind |
4048171 |
Bossert et al. |
Sep 1977 |
|
4145432 |
Sato |
Mar 1979 |
|
4253248 |
Franckowiak et al. |
Jul 1985 |
|
Foreign Referenced Citations (3)
Number |
Date |
Country |
0111455 |
Jun 1984 |
EPX |
3130041 |
Feb 1983 |
DEX |
3206671 |
Sep 1983 |
DEX |
Non-Patent Literature Citations (1)
Entry |
Schramm et al., Nature vol. 303, Jun. 9, 1983. |
Continuations (1)
|
Number |
Date |
Country |
Parent |
713053 |
Mar 1985 |
|