Claims
- 1. A crystalline chemical composition comprising a compound of formula (I)
- 2. A composition according to claim 1 wherein the guest molecule preferably has a relative molecular weight in the range 16 to 150.
- 3. A composition according to claim 1 wherein the guest molecule conains a moiety capable of acting as a hydrogen bond acceptor.
- 4. A composition according to claim 1 wherein the guest molecule is selected from the list consisting of cyclopentanone, dimethylsulfoxide, ethanol, propan-1-ol, butan-1-ol, 1,4-dioxane, ethyl formate, methyl acetate, water and acetic Acids
- 5. A composition according to claim 1 wherein the guest molecule is acetone.
- 6. A composition according to claim 1 wherein the guest molecule is methylethylketone.
- 7. A composition according to claim 1 wherein the guest molecule is tetrahydrofuran.
- 8. A composition according to claim 1 wherein the guest molecule is propan-2-ol.
- 9. A composition according to claim 1 wherein the guest molecule is dimethylformamide.
- 10. A composition according to claim 1 wherein the guest molecule is butan-1-ol
- 11. A composition according to claim 1 wherein the guest molecule is methyl acetate.
- 12. A composition according to claim 1 wherein the guest molecule is acetic acid.
- 13. A composition according to claim 1 wherein the guest molecule is propan-1-ol.
- 14. A composition according to claim 1 wherein the guest molecule is ethanol.
- 15. A composition according to claim 1 wherein the guest molecule is ethyl formate.
- 16. A composition according to claim 1 wherein the guest molecule is 1,4-dioxane.
- 17. A composition according to claim 1 wherein the guest molecule is dimethylsulphoxide.
- 18. A composition according to claim 1 wherein the guest molecule is N-methyl-2-pyrrolidinone.
- 19. A composition according to claim 1 wherein the guest molecule is dimethylacetamide.
- 20. A composition according to claim 1 wherein the guest molecule is cyclopentanone.
- 21. A composition according to claim 1 wherein the guest molecule is water.
- 22. A composition according to claim 1 wherein the guest molecule is ε-caprolactam.
- 23. A composition according to claim 1 wherein the ratio of compound of formula (I) to guest molecule is 1:2.0-0.3.
- 24. A pharmaceutical composition comprising a composition according to claim 1 together with a physiologically acceptable diluent or carrier.
- 25. A method for the treatment of a human or animal subject with an inflammatory and/or allergic condition, which method comprises administering to said human or animal subject an effective amount of the composition according to claim 1.
- 26. A pharmaceutical composition comprising a composition according to claim 1 in combination with another therapeutically active agent.
- 27. A composition according to claim 26 wherein the other therapeutically active ingredient is a long acting β2-adrenoreceptor agonist.
- 28. A process for preparing a composition according to claim 1 which comprises
(a) crystallising the composition from a solution containing a compound of formula (I) and the guest molecule; or (b) contacting the compound of formula (I) or another composition according claim 1 in solid form with a liquid containing the guest molecule and obtaining the composition therefrom; or (c) contacting a compound of formula (I) or another composition according to claim 1 in solid form with a vapour containing the guest molecule.
- 29. A process for preparing compound of formula (I) in unsolvated form in the form of equant or substantially equant particles by a process comprising:
(a) preparing a composition according to claim 1 in the form of equant or substantially equant particles; and (b) removing the guest molecule.
- 30. A process according to claim 29 wherein the composition is a composition with propan-2-ol or acetone as guest molecule.
Priority Claims (1)
Number |
Date |
Country |
Kind |
0019172.6 |
Aug 2001 |
GB |
|
Parent Case Info
[0001] This application is a Continuation-in-part of a 35 USC 371 patent application Ser. No. 09/958,050 filed on Oct. 2, 2001 in the United States Patent and Trademark Office, for which an International Patent Application No. PCT.GB01.03495 was filed on Aug. 3, 2001, which claims priority to United Kingdom Patent Application No. GB 0019172.6 filed Aug. 5, 2000.
Continuations (1)
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Number |
Date |
Country |
Parent |
PCT/GB01/03495 |
Aug 2001 |
US |
Child |
09958050 |
Oct 2001 |
US |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
09958050 |
Oct 2001 |
US |
Child |
10067010 |
Feb 2002 |
US |