Claims
- 1. An antibiotic substance SF-1540 which has the following physicochemical properties:
- an optical rotation of [.alpha.].sub.D.sup.20 =+31.6.degree. in methanol,
- an elementary analysis of 65.16% carbon, 8.24% hydrogen, 2.17% nitrogen and 23.79% oxygen,
- an ultraviolet absorption spectrum shown in FIG. 1, an infrared absorption sprectrum shown in FIG. 2 and a nuclear magnetic resonance spectrum shown in FIG. 3,
- a color reaction positive to potassium permanganate and sulfuric acid and negative to ninhydrin,
- sparingly soluble in water and cyclohexane, and soluble in methanol, ethanol, acetone, chloroform, ethyl acetate, n-butanol, benzene, carbon tetrachloride and ethyl acetate.
- 2. A process for production of the antibiotic substance SF-1540 as defined in claim 1 which comprises culturing Streptomyces hygroscopicus SF-1540 (ATCC 31257) in a culture medium under aerobic conditions until substantial antibiotic activity has been imparted to said medium and isolating and recovering the substance SF-1540 from the cultured broth.
- 3. A process according to claim 2 wherein said microorganism is cultured at a temperature of from 25.degree. to 35.degree. C. for from 2 to 5 days.
- 4. A process according to claim 2 wherein said culture medium contains glucose, wheat embryo, soluble vegetable protein and sodium chloride.
- 5. A derivative of the antibiotic substance SF-1540 as defined in claim 1 which has the following physicochemical properties:
- an optical rotation of [.alpha.].sub.D.sup.20 =+21.degree. in chloroform,
- an elementary analysis of 66.69% carbon, 8.62% hydrogen, 1.68% nitrogen and 23.96% oxygen,
- an ultraviolet absorption spectrum shown in FIG. 4, an infrared absorption spectrum shown in FIG. 5 and a nuclear magnetic resonance spectrum shown in FIG. 6,
- a color reaction positive to potassium permanganate and sulfuric acid and negative to ninhydrin,
- sparingly soluble in water, and soluble in methanol, ethanol, acetone, chloroform and ethyl acetate.
- 6. An antiprotozoal composition comprising an effective antiprotozoal amount of the derivative of SF-1540 as defined in claim 5 and a pharmaceutically acceptable carrier.
- 7. An agricultural composition comprising an effective fungicidal amount of the derivative of SF-1540 as defined in claim 5 and a carrier.
Priority Claims (2)
Number |
Date |
Country |
Kind |
50/157469 |
Dec 1975 |
JPX |
|
51/43659 |
Apr 1976 |
JPX |
|
RELATED APPLICATION
This application is a continuation-in-part of our application Ser. No. 751,437, filed Dec. 16, 1976, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3993749 |
Sehgal et al. |
Nov 1976 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
751437 |
Dec 1976 |
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