Claims
- 1. A compound having the formula
- 2. A compound of claim 1 wherein R1 is cycloalkyl of 3 to 8 carbon atoms.
- 3. A compound of claim 2 wherein said cycloalkyl is substituted with an alkyl of 1 to 6 carbon atoms.
- 4. A compound of claim 1 wherein X is 4-fluoro- or 5-fluoro-.
- 5. A compound of claim 1 wherein R4 is phenyl or pyridyl.
- 6. A compound of claim 5 wherein R4 is phenyl, pyrid-3yl or pyrid-4yl.
- 7. A compound of claim 1 which is 1-methyl-cyclohexanecarboxylic acid {(1R)-1-benzyl-2-[4-(5-fluoro-2-methoxy-phenyl)-piperidin-1-yl]-ethyl}-methyl-amide, or a pharmaceutical salt thereof.
- 8. A compound of claim 1 which is 1-methyl-cyclohexanecarboxylic acid {(1 R)-1-benzyl-2-[4-(5-fluoro-2-methoxy-phenyl)-1,2,5,6-tetrahydro-4H-pyridin-1-yl]-ethyl}-methyl-amide, or a pharmaceutical salt thereof.
- 9. A compound of claim 1 which is (R)-Cyclohexanecarboxylic acid{1-benzyl-2-[4-(2-methoxy-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl}-amide, or a pharmaceutical salt thereof.
- 10. A compound of claim 1 which is (R)-1-Methyl-cyclohexanecarboxylic acid{1-benzyl-2-[4-(2-methoxy-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl}-amide, or a pharmaceutical salt thereof
- 11. A compound of claim 1 which is (R)-1-Methyl-cyclohexanecarboxylic acid {1-benzyl-2-[4-(2-methoxy-phenyl)-piperidin-1-yl]-ethyl}-amide, or a pharmaceutical salt thereof
- 12. A compound of claim 1 which is (R)-Cyclohexanecarboxylic acid{1-benzyl-2-[4-(2-methoxy-phenyl)-piperidin-1-yl]-ethyl}-amide, or a pharmaceutical salt thereof.
- 13. A compound of claim 1 which is 1-Methyl-cyclohexanecarboxylic acid{(1R)-2-[4-(2-methoxy-phenyl)-piperidin-1-yl]-1-pyridin-3-ylmethyl-ethyl}-amide, or a pharma-ceutical salt thereof.
- 14. A compound of claim 1 which is 1-Methyl-cyclohexanecarboxylic acid{(1R)-2-[4-(2-methoxy-phenyl)-piperidin-1-yl]-1-pyridin-4-ylmethyl-ethyl}-amide, or a pharma-ceutical salt thereof.
- 15. A compound of claim 1 which is Cyclohexanecarboxylic acid{(1R)-2-[4-(2-methoxy-phenyl)-piperidin-1-yl]-1-pyridin-3-ylmethyl-ethyl}-methyl-amide, or a pharmaceutical salt thereof.
- 16. A compound of claim 1 which is Cyclohexanecarboxylic acid{(1R)-2-[4-(2-methoxy-phenyl)-piperidin-1-yl]-1-pyridin-4-ylmethyl-ethyl}-methyl-amide, or a pharmaceutical salt thereof.
- 17. A compound of claim 1 which is (R)-Cyclohexanecarboxylic acid{1-(4-methoxybenzyl)-2-[4-(2-methoxy-phenyl)-piperidin-1-yl]-ethyl}-amide, or a pharmaceutical salt thereof.
- 18. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
- 19. A method of treating a patient suffering from a disorder of the central nervous system associated with the 5-hydroxytryptamine 1A receptor subtype comprising administering a therapeutically effective amount of a compound having the formula
- 20. The method of claim 19 wherein the disorder is depression, anxiety or panic.
- 21. The method of claim 19 wherein the disorder is sleep disorder or sexual dysfunction.
- 22. The method of claim 19 wherein the disorder is drug or alcohol addiction.
- 23. The method of claim 19 wherein the disorder is a cognitive disorder.
- 24. The method of claim 19 wherein the disorder is a neurodegenerative disease.
- 25. The method of claim 24 wherein the neurodegenerative diseases is Parkinson's disease or Alzheimer's disease.
- 26. The method of claim 19 wherein the disorder is migraine.
- 27. The method of claim 19 wherein the disorder is obesity.
- 28. The method of claim 19 further comprising administration of a serotonin reuptake inhibitor.
- 29. The method of claim 28 wherein the serotonin reuptake inhibitor is selected from the group consising of fluoxetine, fluvoxamine, paroxetine, sertraline and venlafaxine.
Parent Case Info
[0001] This application claims the benefit of U.S. Provisional (Not Yet Known), filed Dec. 17, 1998.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60160088 |
Dec 1998 |
US |
Divisions (1)
|
Number |
Date |
Country |
Parent |
09459801 |
Dec 1999 |
US |
Child |
09954784 |
Sep 2001 |
US |