NOVEL AZETIDINE CB1 ANTAGONISTS

Information

  • Research Project
  • 8014395
  • ApplicationId
    8014395
  • Core Project Number
    271200900031C-2-0-1
  • Full Project Number
    271200900031C-2-0-1
  • Serial Number
    0
  • FOA Number
  • Sub Project Id
  • Project Start Date
    9/30/2009 - 14 years ago
  • Project End Date
    9/29/2011 - 12 years ago
  • Program Officer Name
  • Budget Start Date
    -
  • Budget End Date
    -
  • Fiscal Year
    2010
  • Support Year
  • Suffix
  • Award Notice Date
    -
Organizations

NOVEL AZETIDINE CB1 ANTAGONISTS

To discover novel CB1 cannabinoid receptor antagonists as: a) potential cnadidates as medications for treatment of the ill effects of stimulants including cocaine and methamphetamine and other drugs of abuse;b) useful pharmacological and biochemical probes for studying the cannabinergic system. It has been shown that the selective CB1 antagonist SR141716A attenuates relapse induced by re-exposure to cocaine-associated cues or to cocaine itself. However, this compound was shown to exhibit undesirable side effects, was not approved in the US, and was withdrawn from clinical practice in Europe. These side effects may be chemotype-related, attributable to suboptimale ADME and/or its inverse antagonist profile. This contract seeks to develop a novel series of analogs based on a structurally distinct benzhydryloxyazetidine prototype.

IC Name
NATIONAL INSTITUTE ON DRUG ABUSE
  • Activity
    N44
  • Administering IC
    DA
  • Application Type
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
    23826
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    279
  • Ed Inst. Type
  • Funding ICs
    NIDA:23826\
  • Funding Mechanism
    Contracts, Extramural
  • Study Section
  • Study Section Name
  • Organization Name
    MAKSCIENTIFIC, LLC
  • Organization Department
  • Organization DUNS
    155844017
  • Organization City
    Watertown
  • Organization State
    MA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    024710188
  • Organization District
    UNITED STATES