Novel cocrystallization

Abstract

The present disclosure relates to novel cocrystals and novel methods for cocrystallization. In particular, the disclosure includes cocrystals comprising a salt of an active agent, such as a chloride salt of an active pharmaceutical ingredient. The present disclosure also relates to methods of preparing cocrystals and methods for screening for solid state phases.

Description

FIELD OF THE INVENTION

[0002] The present disclosure describes cocrystals comprising active agents, especially active pharmaceutical ingredients (APIs), and methods relating to cocrystals. In particular, novel cocrystals are provided of a salt of an active pharmaceutical ingredient (such as a salt having chloride as the counterion) and a guest that forms a relatively strong interaction with the counterion. Methods are provided for searching for possible solid state phases of a sample and include solidifying the sample as a cocrystal. Methods are also provided for screening a sample for solid state phases and include solidifying the sample as a cocrystal.

BACKGROUND OF THE INVENTION

[0003] Cocrystals are crystals that contain two or more non-identical molecules. Examples of cocrystals may be found in the Cambridge Structural Database. Examples of cocrystals may also be found at Etter, Margaret C., and Daniel A. Adsmond (1990) “The use of cocrystallization as a method of studying hydrogen bond preferences of 2-aminopyridine” J. Chem. Soc., Chem. Commun. 1990 589-591, Etter, Margaret C., John C. MacDonald, and Joel Bernstein (1990a) “Graph-set analysis of hydrogen-bond patterns in organic crystals” Acta Crystallogr., Sect. B, Struct. Sci. B46 256-262, Etter, Margaret C., Zofia Urbańczyk-Lipkowska, Mohammad Zia-Ebrahimi, and Thomas W. Panunto (1990b) “Hydrogen bond directed cocrystallization and molecular recognition properties of diarylureas” J. Am. Chem. Soc. 112 8415-8426, which are incorporated herein by reference in their entireties. The following articles are also incorporated herein by reference in their entireties: Carl Henrik Görbotz and Hans-Petter Hersleth, 2000, “On the inclusion of solvent molecules in the crystal structures of organic compounds” Acta Cryst. (2000), B56, 625-534; and V. S. Senthil Kumar, Ashwini Nangia, Amy K. Katz and H. L. Carrell, 2002, “Molecular Complexes of Some Mono- and Dicarboxylic Acids with trans-1,4,-Dithiane-1,4-dioxide” American Chemical Society, Crystal Growth & Design, Vol. 2, No. 4, 2002.

[0004] The identification of an optimal composition, formulation, and/or solid state phase is important in the pharmaceutical field, as well as in other fields including nutraceuticals, agricultural chemicals, dyes, explosives, polymer additives, lubricant additives, photographic chemicals, and structural and electronic materials. The new methods described herein may be useful in any of these fields as well as others where solid materials are used.

SUMMARY OF THE INVENTION

[0005] As one aspect, novel cocrystals are provided. The novel cocrystals comprise one or more active agents, particularly of the salts of such active agents.

[0006] As another aspect, novel cocrystallization methods are provided which have increased probability of successful cocrystallization. A suitable method of cocrystallization may include identifying a crystal comprising a salt of an active agent, wherein the salt comprises the active agent and a negative counterion. One may identify coordination of the negative counterion (for example, its hydrogen bond interactions within that crystal). One may then select a guest to coordinate more strongly with the negative counterion than the coordination within the crystal. Based upon the evaluation of the nonbonded interactions involving one component of an active agent and/or guest, one selects another molecule or molecules or a salt that will coordinate well, or interact strongly with a hydrogen bond acceptor site that has been identified as being involved in a weak hydrogen bond. If the acceptor site has the ability to interact with stronger hydrogen bond donors, and thus form a more energetically favorable interaction, yet it is presently involved in a weak interaction, then the opportunity exists to replace the weak donor with a stronger one. For example, if a strong hydrogen bond acceptor is interacting with a weak hydrogen bond donor in a crystal, a cocrystal could be created by adding a strong hydrogen bond donor molecule to the system which would replace the weak donor and bond to the strong acceptor site in the resulting cocrystal. After the selection of a suitable guest, a solution, melt, or physical mixture comprising the active agent, the counterion, and the guest may be prepared. The solution or melt is subjected to a crystallization process, such as evaporation, cooling, or any of the many well-known processes for forming a crystal from a solution or melt. The physical mixture can be ground to form the cocrystal. A cocrystal is formed comprising the salt of the active agent and the guest.

[0007] As another aspect, the present disclosure provides a cocrystallization method that produces a novel type of chloride salt cocrystal structure. The method can be useful for generating beneficial solid chloride salts of APIs in cases where the chloride salt was previously disfavored.

[0008] As yet another aspect, novel forms of salts of active pharmaceutical ingredients are provided. For example, the present disclosure provides novel cocrystals of fluoxetine HCl and benzoic acid; fluoxetine HCl and succinic acid; and fluoxetine HCl and fumaric acid. Novel forms or solid state phases of active pharmaceutical ingredients may be prepared for which there are no known polymorphs, solvates or hydrates, or where such polymorphs, solvates or hydrates were disfavored.

[0009] As a further aspect, a method of modifying one or more physical properties of a drug formulation or drug composition which comprises an API, the method comprising forming a series of cocrystals of the API with a plurality of guests. The method may further comprise measuring a physical property of the cocrystal and/or adjusting the drug formulation or drug composition.

[0010] As yet another aspect, an improved method for screening or selecting the optimal solid state phase for active agents, particularly active pharmaceutical ingredients, and salts thereof, is provided. The screening method comprises crystallizing or attempting to crystallize the free base of the active agent, a chloride salt of the active agent, and optionally other salts of the active agent, and cocrystallizing or attempting to cocrystallize the free base of the active agent, a chloride salt of the active agent, and optionally other salts of the active agent. The method may further comprise evaluating one or more properties of the solid forms, such as one or more physical properties.

BRIEF DESCRIPTION OF THE DRAWINGS

[0011] FIGS. 1(a) and (b) illustrate a crystal structure of an active pharmaceutical ingredient and a cocrystal structure containing the same API with a guest molecule.

[0012] FIGS. 2(a) and (b) are drawings of two-dimensional and three-dimensional models of a cocrystal of fluoxetine HCl and benzoic acid (1:1).

[0013] FIGS. 3(a) and (b) are drawings of two-dimensional and three-dimensional models of a cocrystal of fluoxetine HCl and succinic acid (2:1).

[0014] FIGS. 4(a) and (b) show a two-dimensional drawing of nabumetone and 2,3-naphthalenediol and a three-dimensional model of a cocrystal of nabumetone and 2,3-naphthalenediol (1:1).

[0015] FIG. 5 shows examples of general classes of guests.

DETAILED DESCRIPTION OF THE INVENTION

[0016] The present disclosure provides a way of investigating cocrystals and a way of creating new solid state phases in which one or more active agents are cocrystallized with a guest. By cocrystallizing an active agent with a guest such as a pharmaceutically acceptable compound, one can create new solid state phases which may have improved properties over existing solid state phases of that active agent. For example, new drug formulations comprising cocrystals of active pharmaceutical ingredients may have superior properties over existing drug formulations. The active agent and guest will vary depending on the industry. For example, in the pharmaceutical field, the active agent or guest may be an API, and the other component of the cocrystal must be a pharmaceutically acceptable compound. The present techniques are also applicable to active agents from other fields including nutraceuticals, agricultural chemicals, pigments, dyes, explosives, polymer additives, lubricant additives, photographic chemicals, and structural and electronic materials.

[0017] Broadly speaking, one aspect relates to the use of undercoordinated counterions to facilitate cocrystallization. While the inventor does not wish to be bound to theory, the inventor believes excellent cocrystals may be formed using hydrochloride salts and similar salts which are strong hydrogen bond acceptors yet contain relatively undercoordinated ions. “Undercoordinated” in this case refers to ions, for example a chloride ion, that are able to form a number of strong hydrogen bonds. An undercoordinated counterion may have hydrogen bonds within a crystal of that salt, but it could form additional hydrogen bonds in a cocrystal and/or form relatively stronger hydrogen bonds in a cocrystal with a guest. An ion is “undercoordinated” when the system is limited in the number of hydrogen bond donors that are available and bonded to the ion. In these cases, the extra hydrogen bond acceptor sites are typically filled by weakly interacting donors such as C—H groups. Chloride ions are strong hydrogen bond acceptors in a crystal structure. In a crystal structure such as fluoxetine hydrochloride, the chloride ion coordinates to the two strong hydrogen bond donors available in the system, and the chloride ion also has three weaker CH—Cl interactions resulting in a pseudo-octahedral coordination environment. There is an opportunity for bonding with these coordination sites, by displacing the weak CH donors that the chloride has recruited to fill its coordination sphere with somewhat stronger hydrogen bond donors from a guest such as benzoic acid, succinic acid, fumaric acid, or another carboxylic acid.

[0018] It is useful in forming cocrystals to recognize that relatively weak interactions may be replaced by stronger interactions, even though those stronger interactions may be relatively weak themselves, compared to other interactions. For example, an undercoordinated chloride may have one strong hydrogen bond donor and several weak hydrogen bond donors or two strong hydrogen bond donors and several weak hydrogen bond donors. In a cocrystal, weaker interactions may be replaced by stronger interactions, although those stronger interactions may still be weaker than the strong interactions (charge-assisted hydrogen bonds) present in fluoxetine HCl crystals. The strongest interactions involving chloride ions in crystal structures of organic salts are the charge assisted hydrogen bonds that invariably form between the protonated nitrogen base and the chloride ion. The strongest interactions between neutral molecular groups and the chloride ion involve acids and the chloride ion. Carboxylic acids, for instance, have strong interactions with chloride ions. It can be seen that a combination of carboxylic acids and hydrochloride salts of nitrogen containing bases are especially well suited to cocrystal formation (as demonstrated by the examples included). Furthermore, it can be anticipated that different combinations of these elements could lead to other cocrystals. For example, the active molecule of interest may contain either the neutral carboxylic acid moiety or the protonated nitrogen. The potential exists to cocrystallize an API having a neutral carboxylic acid moiety with a guest that is a hydrochloride salt of a nitrogen-containing organic base.

[0019] It is further contemplated that the nature of the protonated nitrogen base will affect the potential for cocrystallization. Numerous strong hydrogen bond donor groups will compete with the carboxylic acid guest for the open acceptor sites on the chloride ion. In order to favor cocrystal formation, the nitrogen base is preferably a tertiary amine because this presents a situation where only one strong charged hydrogen bond donor exists and thus will only occupy one site on the chloride acceptor. Additionally, systems that have only this one tertiary amine and no other strong donors present an especially favorable system for potential cocrystallization. Protonated secondary amines with two N—H donor groups are also favored, although protonated primary amines may also be used. Special consideration must be taken for systems with additional strong hydrogen bond donor and acceptor sites in order to determine the potential for cocrystallization and the optimal guest molecule type for cocrystallization. The potential for cocrystallization involving a carboxylic acid and a hydrochloride salt may be reduced as the number of available strong donors in the system is increased. Additional guidance as to evaluating undercoordination may be found in the inventor's prior work (which is incorporated by reference herein in its entirety), particularly in its discussion of nonbonded motifs: Scott L. Childs, “Nonbonded Interactions In Molecular Crystal Structures”, Emory Univ., USA, available from UMI, Order No. DA3009424 (288 pp.), Dissertation Abstract Int. Ref. B2001, 62(3), 1394. In some circumstances, the undercoordination can be determined by measuring distances, comparing profiles in the Cambridge Structural Database, measuring the pKa of the donors and acceptors, or evaluating the ratio of strong hydrogen bond donors to available acceptors. Other crystal engineering theories may also be used.

[0020] The formation of cocrystals is very unpredictable. It is difficult to foresee structural changes as a function of changes in molecular substitution patterns or in molecular geometry. However, the present disclosure provides greater predictability and better probability of success in designing and forming cocrystals.

[0021] The present techniques may be employed to generate a wide variety of cocrystals of active agents and guests. For example, the present techniques may be used to generate cocrystals of a salt of an active agent, such as a salt of an active pharmaceutical ingredient, with a neutral guest. Alternatively, a cocrystal of a neutral or zwitterionic active agent (or a salt of an active agent) may be generated with a guest salt, which includes a positive ion and a negative ion of its own. Where the active agent is provided in a salt, it may be positively or negatively charged and have a negative or positive counterion. As an example, for fluoxetine HCl, the active agent fluoxetine is positively charged by virtue of accepting a proton from HCl to form a protonated amine, and chloride is present as a negative counterion. Furthermore, some of the present methods may be employed with a neutral or zwitterionic active agent to form a cocrystal with a neutral guest or ionic guest.

[0022] The present techniques provide an opportunity to create a stable solid state phase of a hydrochloride salt of an API that was previously found to have properties that were unsuitable for development. Opportunities for continued development in such a situation have often relied on the fortuitous formation of a stable hydrate or solvate, but the present techniques present the ability to systematically examine alternative formulations of the hydrochloride salt by cocrystallizing the hydrochloride salt of the API with appropriate guest molecules.

[0023] Cocrystallization may be an attractive technique for salts of APIs that have been rejected due to problems relating to physical properties. Since cocrystals may have different physical properties than the individual components, APIs with unfavorable physical properties can be cocrystallized with suitable guest molecules and the physical properties of the resulting crystalline solids can be evaluated.

[0024] The cocrystals of fluoxetine HCl provide examples of the modification of a physical property (solubility) of an API salt. Cocrystals of fluoxetine HCl:benzoic acid are less soluble and have a lower dissolution rate than crystals of fluoxetine HCl, while cocrystals of fluoxetine HCl:succinic acid are more soluble and have a faster dissolution rate than crystals of fluoxetine HCl.

[0025] Other physical properties of APIs or their salts that may be modified by forming a cocrystal include: melting point, density, hygroscopicity, crystal morphology, loading volume, compressibility, and shelf life. Furthermore, other properties such as bioavailability, toxicity, taste, physical stability, chemical stability, production costs, and manufacturing method may be modified by the use of the present cocrystallization techniques.

[0026] An active agent can be screened for possible cocrystals where polymorphic forms, hydrates or solvates are especially problematic. A neutral compound that can only be isolated as amorphous material could be cocrystallized. Forming a cocrystal may up-grade the performance of a drug formulation of an active pharmaceutical ingredient by changing physical properties. Some APIs are problematic during wet granulation and compression stages. A bioequivalent cocrystal could rectify this problem.

[0027] A cocrystal can be used to isolate or purify a compound during manufacturing. If it is desirable to identify all of the solid state phases of an active pharmaceutical ingredient, then cocrystallization may be particularly desirable.

[0028] The present techniques provide new methods of developing and screening active pharmaceutical ingredients. Non-toxic cocrystalline forms of neutral active pharmaceutical ingredients may be prepared, screened, tested, and commercialized. Screening based on cocrystal formation is equivalent in many respects to a salt-screen for neutral APIs. Furthermore, new types of HCl salt structures may be prepared. The properties of hydrochloride salts can be tuned and perfected. New, unique, stable, and marketable phase of hydrochloride salts may be prepared. One can choose whether to make the formulation more soluble or less soluble.

[0029] As another aspect, the present techniques may also be used to remove or reduce the water of hydration, and/or to prepare a cocrystal substantially free of water of hydration. A hydrate may be viewed as a cocrystal having water as the guest. Water and guest acids perform a similar role in the stabilization of the crystal structure. In fact, about 28% of the hydrochloride salts of API in the Cambridge Structure Database are hydrates, compared to about 8% of all other organic structures. This indicates an affinity for hydration. The present techniques both capitalize and rectify this affinity, in that an affinity for cocrystallization (as evidence by hydration) is likely indicated, and this affinity for cocrystallization may be employed for the formation of cocrystals with a suitable guest, such as an acid, for example a carboxylic acid. Indeed, in many cocrystals, an acid may have stronger interactions than water molecules and may displace the water of hydration during the formation of the cocrystal. Accordingly, the present techniques provide a method of preparing a cocrystal from a hydrate. A hydrate of a salt is provided, and the hydrate comprises water of hydration. A guest is selected to coordinate with the counterion. Preferably, the guest coordinates more strongly with the counterion than the solvent does. A solution, melt or physical mixture is prepared which comprises the hydrate and the guest. The solution or melt is subjected to a crystallization process, or the physical mixture is subjected to grinding, and a cocrystal comprising the salt of the active agent and the guest is formed, and the salt comprises the active agent and a counterion. Similarly, the present techniques provide a method of preparing a cocrystal from a solvate. A solvate of a salt is provided, and the solvate comprises solvent molecules coordinated with the salt. A guest is selected to coordinate with the counterion. Preferably, the guest coordinates more strongly with the counterion than the solvent does. A solution, melt or physical mixture is prepared comprising the solvate and the guest. The solution or melt is subjected to a crystallization process, or the physical mixture is subjected to grinding, and a cocrystal comprising the salt of the active agent and the guest is formed. The salt comprises the active agent and a counterion.

[0030] FIGS. 2(a) and (b) are drawings of two-dimensional and three-dimensional models of a cocrystal of fluoxetine HCl and benzoic acid (1:1). FIG. 2(a) shows a two-dimensional model in which the chloride ion interacts with the hydrogens of the amine group of fluoxetine and of the hydroxyl group of benzoic acid. Through these interactions, which may be characterized as hydrogen bonding, fluoxetine hydrochloride and benzoic acid form a supramolecular structure that may be the basis of a cocrystal. FIG. 2(b) shows a three-dimensional model of the supramolecular organization of fluoxetine hydrochloride and benzoic acid.

[0031] FIG. 3(a) and (b) are drawings of two-dimensional and three-dimensional models of a cocrystal of fluoxetine HCl and succinic acid (2:1). FIG. 3(a) shows a two-dimensional model in which the chloride ion interacts with the hydrogens of the ammonium group of fluoxetine and of the hydroxyl group of succinic acid. Through these interactions, which may be characterized as hydrogen bonding, two molecules of fluoxetine hydrochloride and one molecule of succinic acid form a supramolecular structure that may be the basis of a cocrystal. FIG. 3(b) shows a three-dimensional model of the supramolecular organization of the molecules of fluoxetine hydrochloride and succinic acid.

[0032] FIGS. 4(a) and (b) show a two-dimensional drawing of nabumetone and 2,3-naphthalenediol and a three-dimensional model of a cocrystal of nabumetone and 2,3-naphthalenediol (1:1).

[0033] Active Agent

[0034] The active agent is the molecule whose activity is desirable or the object of interest. It is contemplated that one or more active agents may be employed in a cocrystal, according to any of the present techniques. For example, where the active agent is an active pharmaceutical ingredient, the pharmaceutical activity of the active agent is desirable. Other active agents may be nutraceuticals, agricultural chemicals, pigments, dyes, explosives, polymer additives, lubricant additives, photographic chemicals, or structural and electronic materials.

[0035] The active agent may be provided as a salt. It is contemplated that one or more salts may be employed in a cocrystal, according to any of the present techniques. The salt may be prepared from the active agent or obtained from a commercial source. Hydrochloride salts of active pharmaceutical ingredients, especially of amine APIs, are especially preferred in the pharmaceutical industry.

[0036] In general, it is contemplated that the present techniques will have particularly good results as applied to amine HCl salts as well as other ammonium salts as described in more detail herein. In ammonium acid salts, the active agent has at least one amine moiety which is relatively basic (at least one relatively basic nitrogen), and a salt is formed with an acid that reacts with the amine moiety. Cocrystals may be then formed between the ammonium salts and guests which act as hydrogen-bond donors to the salts. Cocrystals may be formed of chloride salts of APIs, for example buspirone hydrochloride, fluoxetine hydrochloride, and metformin hydrochloride.

[0037] The present cocrystals may comprise salts other than chloride salts—the hydrochloride API salts that are listed above are only a sampling of the relevant compounds because the starting material need not be a known hydrochloride. Indeed, many relevant APIs are salts that are not HCl salts because the HCl salt was not believed to be an appropriate material and a different salt was commercialized instead. The present techniques may enable one to employ an HCl salt of an API that is marketed as another type of salt. Alternatively, it may be desirable to employ a salt other than an HCl salt, by replacing the HCl or by forming a salt comprising an active agent that acts as a base with an acid other than HCl. The following acids provide anionic counterions that would be used to replace chlorine. These are relatively strong acids, and include but are not limited to mineral acids, and the carboxylic acid guest is expected to form one or more hydrogen bonds with a hydrogen bond acceptor on the anionic counterion. The list is the conjugate acid that would react with a basic active agent to form a salt:

[0038] sulfuric acid

[0039] phosphoric acid

[0040] hydrobromic acid

[0041] nitric acid

[0042] pyrophosphoric acid

[0043] methanesulfonic acid

[0044] thiocyanic acid

[0045] naphthalene-2-sulfonic acid

[0046] 1,5-naphthalenedisulfonic acid

[0047] cyclamic acid

[0048] p-toluenesulfonic acid

[0049] maleic acid

[0050] L-aspartic acid

[0051] 2-hydroxy-ethanesulfonic acid

[0052] glycerophosphoric acid

[0053] ethanesulfonic acid

[0054] hydroiodic acid

[0055] The present techniques also extend beyond salts as starting materials and also include many weak bases that may have been marketed as neutral forms because the known salts did not have appropriate properties. These salts could be revisited and attempts could be made to cocrystallize the HCl salt. For example, a drug formulation marketed as a tartrate salt of an API could be reformulated by cocrystallizing the HCl salt of the active molecule with an appropriate guest molecule. Thus, cocrystallization could make a useful HCl cocrystal out of the API that is currently marketed as a tartrate, sulfate, or other salt formulation. For this reason the present disclosure includes APIs that are not HCl salts as starting materials.

[0056] Furthermore, the present techniques relate to salts other than chloride salts. It is contemplated that hydrobromide salts and sodium salts of APIs may especially benefit from the present techniques, since they form relatively strong nonbonded interactions. For example, the hydrobromide salts citalopram hydrobromide and galantamine hydrobromide are contemplated for cocrystallization with benzoic acid, succinic acid, and other guests compatible with hydrochloride salts.

[0057] The present techniques may be employed to form cocrystals of sodium salts of APIs such as, for example, naproxen sodium, tolmetin sodium, and warfarin sodium. When a sodium salt (or other salt of an API having a positive counterion) is employed, different guests are expected to be suitable for cocrystallization than when a hydrochloride salt (or other anionic salt) of an API is employed.

[0058] Anions and Cations

[0059] As one aspect, the active agent is provided as a salt. A salt of the active agent is formed. Alternatively or additionally, the guest is provided as a salt or a salt of the guest is formed. The salt may comprise the active agent and a counterion that is either a cation or an anion. Among the preferred cations (including cations as well as compounds that can form cations) are aluminum, ammonium, benzathine, calcium, diethanolamine, diethylamine, dimeglumine, disodium, lithium, lysine, magnesium, meglumine, potassium, sodium, and zinc. Among the preferred anions are acetate, L-aspartate, besylate, bicarbonate, carbonate, D-camsylate, L-camsylate, citrate, edisylate, fumarate, gluconate, hydrobromide/bromide, hydrochloride/chloride, D-lactate, L-lactate, DL-lactate, D,L-malate, L-malate, mesylate, pamoate, phosphate, succinate, sulfate, D-tartrate, L-tartrate, D,L-tartrate, meso-tartrate, benzoate, gluceptate, D-glucuronate, hybenzate, isethionate, malonate, methylsufate, 2-napsylate, nicotinate, nitrate, orotate, stearate, tosylate, acefyllinate, aceturate, aminosalicylate, ascorbate, ascorbate, borate, butyrate, camphorate, camphocarbonate, decanoate, hexanoate, cholate, cypionate, dichloroacetate, edentate, ethyl sulfate, furate, fusidate, galactarate (mucate), galacturonate, gallate, gentisate, glutamate, glutamate, glutarate, glycerophosphate, heptanoate (enanthate), hydroxybenzoate, hippurate, phenylpropionate, iodide, xinafoate, lactobionate, laurate, maleate, mandelate, methanesufonate, myristate, napadisilate, oleate, oxalate, palmitate, picrate, pivalate, propionate, pyrophosphate, salicylate, salicylsulfate, sulfosalicylate, sulfosalicylate, tannate, terephthalate, thiosalicylate, tribrophenate, valerate, valproate, adipate, 4-acetamidobenzoate, camsylate, octanoate, estolate, esylate, glycolate, thiocyanate, and undecylenate.

[0060] When a metal cation is employed as a counterion of the active agent, the interaction between guest and cation is not a hydrogen bond but rather is an intermolecular interaction between an electron rich group such as a carbonyl and the metal cation. This interaction is often not as strong as a hydrogen bond, but is still a favorable interaction and thus can contribute to the stabilization of a cocrystal.

[0061] The HCl salt of an active pharmaceutical ingredient is especially preferred to create a new type of cocrystal. In this type of solid state phase, one can cocrystallize the HCl salt with a neutral guest molecule. By doing this one can create solid state phases with specific properties. For instance one can make a solid comprising an active pharmaceutical ingredient having greater or lesser intrinsic solubility and/or a faster or slower dissolution rate, depending on the guest compound that is chosen.

[0062] Guests

[0063] The guest is present in order to form the cocrystal with the active agent. It is contemplated that one or more guests may be employed in a cocrystal, according to any of the present techniques. Accordingly, the guest is not required to have an activity of its own, although it may have some activity that does not overly derogate from the desired activity of the active agent. In some situations, the guest may have the same activity as or an activity complementary to that of the active agent. The guest may be another API. For example, some guests may facilitate the therapeutic effect of an active pharmaceutical ingredient. For pharmaceutical formulations, the guest may be any pharmaceutically acceptable molecule(s) that forms a cocrystal with the API or its salt. The RTECS database is a useful source for toxicology information, and the GRAS list contains about 2500 relevant compounds.

[0064] The guest may be neutral (such as benzoic acid and succinic acid in the examples below) or ionic (such as sodium benzoate or sodium succinate). Neutral guests are nonionic guests. Ionic guests are compounds or complexes having ionic bonds. FIG. 5 shows several general classes of guests (organic bases, organic salts, alcohols & aldehydes, amino acids, sugars, ionic inorganics, aliphatic esters & ketones, organic acids, and aromatic esters & ketones).

[0065] The guest may be an acid that forms hydrogen bonds with the chloride (or other anion). For example, suitable guests which are acids include (but not are not limited to):

[0066] ascorbic acid

[0067] glucoheptonic acid

[0068] sebacic acid

[0069] alginic acid

[0070] cyclamic acid

[0071] ethane-1,2-disulfonic acid

[0072] 2-hydroxyethanesulfonic acid

[0073] 2-oxo-glutaric acid

[0074] naphthalene-1,5-disulfonic acid

[0075] nicotinic acid

[0076] pyroglutamic acid

[0077] 4-acetamidobenzoic acid

[0078] Table 1 sets forth a group of presently preferred guests. It is contemplated that the guests set forth in the Table may be arranged in subgroups based upon molecular structure and/or physiological effect. Furthermore, the foregoing list is intended to provide a written description of any sublist that omits one or more guests.

[0079] Table 2 sets forth another group of preferred guests. It is contemplated that the guests set forth in the Table may be arranged in subgroups based upon molecular structure and/or physiological effect. Furthermore, the foregoing list is intended to provide a written description of any sublist that omits one or more guests.

[0080] Table 3 sets forth the group comprising molecules believed at present to be suitable guests. It is contemplated that the guests set forth in the Table may be arranged in subgroups based upon molecular structure and/or physiological effect. Furthermore, the foregoing list is intended to provide a written description of any sublist that omits one or more guests.

[0081] Ionic guests are salts themselves, and may be formed from bases and acids prior to being used to form cocrystals. For example, the following bases and acids may be reacted to form ionic guests:

Bases

[0082] Ammonia

[0083] L-Arginine

[0084] Benethamine

[0085] Benzathine

[0086] Betaine

[0087] Calcium Hydroxide

[0088] Choline

[0089] Deanol

[0090] Diethanolamine

[0091] Di ethyl amine

[0092] 2-(Diethylamino)ethanol

[0093] 2-Aminoethanol

[0094] Ethylenediamine

[0095] N-Methylglucamine

[0096] Hydrabamine

[0097] 1H-Imidazole

[0098] Lysine

[0099] Magnesium Hydroxide

[0100] Morpholine

[0101] 4-(2-Hydroxyethyl)Morpholine

[0102] piperazine

[0103] Potassium Hydroxide

[0104] Pyrrolidine

[0105] 1-(2-Hydroxyethyl)Pyrrolidine

[0106] Sodium Hydroxide

[0107] Triethanolamine

[0108] Tromethamine

[0109] Zinc Hydroxide

Acids

[0110] (+)-L-Tartaric Acid

[0111] 1,2,2-Trimethyl-1,3-cyclopentanedicarboxylic Acid

[0112] 10-Undecylenic Acid

[0113] 1-Hydroxy-2-naphthoic Acid

[0114] (+)-Camphor-10-sulfonic Acid

[0115] 2,5-Dihydroxybenzoic Acid

[0116] 2-Furancarboxylic Acid

[0117] 2-Mercaptobenzoic Acid

[0118] 3-Cyclopentylpropionic Acid

[0119] 3-Phenylpropionic Acid

[0120] 4-Aminosalicylic Acid

[0121] 4-Hydroxybenzoic Acid

[0122] Acetic Acid

[0123] Adipic Acid

[0124] alpha-Hydroxypropionic Acid

[0125] Benzenesulfonic Acid

[0126] Benzoic Acid

[0127] Carbonic Acid

[0128] Cholic Acid

[0129] Citric Acid

[0130] (−)-D-Tartaric Acid

[0131] (+)-D-Camphoric Acid

[0132] (+)-D-Malic Acid

[0133] (+)-L-Malic Acid

[0134] 2,2-Dichloroacetic Acid

[0135] DL-10-Camphorsulfonic Acid

[0136] DL-Glutamic Acid

[0137] DL-Malic Acid

[0138] DL-Tartaric Acid

[0139] Dodecylsulfuric Acid

[0140] Ethanesulfonic Acid

[0141] Ethylenediaminetetraacetic Acid

[0142] Ethylsulfuric Acid

[0143] Fumaric Acid

[0144] Galactaric Acid

[0145] Gallic Acid

[0146] Gluconic Acid

[0147] Glutaric Acid

[0148] Glycolic Acid

[0149] Hippuric Acid

[0150] Hydriodic Acid

[0151] Hydrobromic Acid

[0152] Hydrochloric Acid

[0153] (−)-L-Apple Acid

[0154] (+)-L-Lactic Acid

[0155] (+)-L-Tartaric Acid

[0156] D,L-Lactic Acid

[0157] Lactobionic Acid

[0158] L-Aspartic Acid

[0159] Lauric Acid

[0160] L-Glutamic Acid

[0161] Maleic Acid

[0162] (−)-L-Malic Acid

[0163] Malonic Acid

[0164] D,L-Mandelic Acid

[0165] Methanesulfonic Acid

[0166] Naphthalene-2-sulfonic acid

[0167] n-Butyric Acid

[0168] n-Decanoic Acid

[0169] n-Hexanoic Acid

[0170] Nitric acid

[0171] n-Tetradecanoic Acid

[0172] Octanoic Acid

[0173] Oleic Acid

[0174] Orotic Acid

[0175] Orthoboric Acid

[0176] Oxalic Acid

[0177] 4-Acetamidobenzoic Acid

[0178] Palmitic Acid

[0179] Pamoic Acid

[0180] Phosphoric Acid

[0181] Picric Acid

[0182] Pivalic Acid

[0183] Propionic Acid

[0184] p-Toluenesulfonic Acid

[0185] Pyrophosphoric Acid

[0186] Salicylic Acid

[0187] Stearic Acid

[0188] Succinic Acid

[0189] Sulfosalicylic Acid

[0190] Sulfuric Acid

[0191] Terephthalic Acid

[0192] Thiocyanic Acid

[0193] Valeric Acid

[0194] Valproic Acid

[0195] Typically, suitable guests will have complementary ability to noncovalently bond to the active agent or its salt, for example the ability to form hydrogen bonds with the active agent or its salt. Suitable guests for active agents having negative counterions include, but are not limited to, compounds having alcohol, ketone, ester, and/or carboxylic acid functionalities. Suitable guests may include organic acids, organic bases, organic salts, alcohols, aldehydes, amino acids, sugars, ionic inorganic compounds, aliphatic esters and ketones, and aromatic esters and ketones.

[0196] Among the presently preferred neutral guests are those which are not liquids at room temperature. Also among the presently preferred neutral guests are carboxylic acids having at least three carbon atoms, alternatively at least four carbon atoms, and which do not form solvates. For example, if the following acids were combined with active agents, the combination would more properly be considered a solvate than a cocrystal: acetic acid, propionic acid, and butyric acid. However, in certain embodiments of the present invention (for example, in certain cocrystals, cocrystallization methods, and screening methods), the use of solvents and solvates may still be desirable, and the use of solvents and solvates is not excluded from the scope of any cocrystal or method except where explicitly stated.

[0197] Detection of Cocrystals

[0198] Cocrystals may be detected by x-ray diffraction analysis or other suitable techniques. The observation of physical properties of a solid (particularly its melting point) which differ from the physical properties of the starting materials and the polymorphs and/or solvates and/or hydrates of the starting materials, is an indicator that a cocrystal has been formed.

[0199] A method of crystal engineering is described. An active pharmaceutical ingredient such as fluoxetine hydrochloride is recognized as possessing a strong hydrogen bond acceptor. The API is screened against a library of strong hydrogen bond donors or other possible guest compounds. Such a library is selected and ordered based upon nontoxicity, physical property, and the availability and geometric arrangement of hydrogen bond donors that are complementary to the API.

[0200] The results from a cocrystal screen of fluoxetine hydrochloride demonstrate a new class of cocrystal that is broadly applicable to a wide variety of hydrochloride salts of APIs. This new approach is a general method that allows creation of cocrystals starting with the hydrochloride salt of the API. Starting with the hydrochloride retains the advantages of the salt, yet one is still able to use the cocrystal method to alter the physical properties of the resulting solid by adding guest molecules.

EXAMPLE 1

Cocrystallization of Fluoxetine HCl and Benzoic Acid

[0201] Cocrystals of fluoxetine HCl:benzoic acid were formed using the following procedures. In one preparation, a 505 mg sample of fluoxetine HCl and 178 mg of benzoic acid were dissolved with heating in 5 mL of acetonitrile. The solution was allowed to crystallize in a small crystallization dish. Well-formed crystalline material formed within 7 minutes. This material was isolated on filter paper and dried in the air to yield 546 (80%) of fluoxetine HCl:benzoic acid (1:1) cocrystal.

[0202] In another preparation, a 5.00 g sample of fluoxetine HCl and 1.76 g of benzoic acid were dissolved in 50 mL of acetonitrile with heating. The solution was allowed to crystallize in a large evaporating dish. The resulting solid was isolated on filter paper and dried in the air to yield 5.40 g (92%) of fluoxetine HCl:benzoic acid (1:1) cocrystal.

[0203] The cocrystal had a relatively slow dissolution rate and lower water solubility. The measured melting point was 134° C.+/−2° C. for the cocrystal. The cocrystal is expected to have a good toxicology profile, since benzoic acid is known to be safe and appears on the GRAS list from the U.S. Food and Drug Administration.

[0204] The resulting cocrystal is a ternary system comprising the protonated API base, the chloride ion, and the neutral guest molecule.

[0205] The present inventor believes there are no known solvates or hydrates of fluoxetine hydrochloride. Thus, the formation of a cocrystal of fluoxetine hydrochloride constitutes a surprising achievement and provides a unique composition.

EXAMPLE 2

Cocrystallization of Fluoxetine HCl and Succinic Acid

[0206] Cocrystals of fluoxetine HCl and succinic acid were prepared as follows. In one preparation, a 458 mg sample of fluoxetine HCl was dissolved in 8 mL of acetonitrile by heating the solution gently. A 78 mg sample of succinic acid was added to the warm solution and dissolved. The solution was allowed to evaporate rapidly in a crystallization dish. Well-formed crystals as blocks formed as the solvent evaporated over 8 minutes. The product was collected on filter paper and dried to yield 401 mg of fluoxetine HCl:succinic acid (2:1) cocrystal (75% yield).

[0207] In another preparation, a 5.00 g sample of fluoxetine HCl and 0.85 g of succinic acid were dissolved in acetonitrile with heating. The solution was allowed to crystallize in an open evaporating dish over a 15 minute period. The solid material was isolated on filter paper and dried to yield 5.40 g (92% yield) of fluoxetine HCl:succinic acid (2:1) cocrystal.

[0208] The measured melting points were 158° C. for fluoxetine HCl, 184° C. for succinic acid, and 137° C. for the cocrystal. The cocrystal is expected to have a good toxicology profile, since succinic acid is known to be safe and appears on the Generally Recognized As Safe (!“GRAS”) list from the U.S. Food and Drug Administration.

EXAMPLE 3

Cocrystallization of Nabumetone and 2,3-naphthalenediol

[0209] As a demonstrative example, a cocrystal comprising a neutral API is described in this example. Cocrystals of nabumetone (a neutral API) and 2,3-naphthalenediol were prepared as follows. A 4.01 g sample of 2,3-naphthalenediol and 5.7 g of nabumetone were dissolved in 50 mL of nitromethane with heating. A solid was formed as the solution cooled and was allowed to stand overnight. The solid was filtered from the remaining solvent and dried in the air to yield 6.61 g (68%) of nabumetone:2,3-naphthalenediol (1:1) cocrystal.

[0210] The resulting cocrystal had a 1:1 molar ratio of nabumetone to 2,3-naphthalienediol. The measured melting points were 80° C. for nabumetone, 162° C. for 2,3-naphthalienediol, and 98° C. for the cocrystal. The cocrystal is expected to have a relatively poor toxicology profile. However, this example demonstrates one basis for the selection of guest molecules: molecular structural similarities. In this case the molecular recognition of the naphthalene moieties of the API and the guest contribute to the stability of the cocrystal. In addition, the stronger alcohol to ketone hydrogen bonds formed by the cocrystal contribute to the stability of the cocrystal. The only hydrogen bond donors available in the API crystal structure are weak C—H groups. The stronger hydrogen bond donors on the guest molecule are able to form stronger intermolecular interaction between the API and guest, compared to the interactions between molecules of the API.

EXAMPLE 4

Crystal Structure Analysis of fluoxetine HCl:benzoic Acid Cocrystal (1:1)

[0211] A suitable cocrystal of fluoxetine HCl:benzoic acid (1:1) was coated with Paratone N oil, suspended in a small fiber loop and placed in a cooled nitrogen gas stream at 100 K on a Bruker D8 SMART APEX CCD sealed tube diffractometer with graphite monochromated MoKα (0.71073A) radiation. Data were measured using a series of combinations of phi and omega scans with 10 second frame exposures and 0.3° frame widths. Data collection, indexing and initial cell refinements were all carried out using SMART software (SMART Version 5.624, 2000, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). Frame integration and final cell refinements were done using SAINT software (SAINT Version 6.02, 2000, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). The final cell parameters were determined from least-squares refinement on 5435 reflections. The SADABS program was used to carry out absorption corrections (SADABS Version 2.03, 2001, George Sheldrick, University of Göttingen).

[0212] The structure was solved using Direct methods and difference Fourier techniques (SHELXTL V5.10, 2000, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). Hydrogen atoms were placed their expected chemical positions using the HFIX command and were included in the final cycles of least squares with isotropic Uij's related to the atom's ridden upon. The C—H distances were fixed at 0.93 Å (aromatic and amide), 0.98 Å (methine), 0.97 Å (methylene), or 0.96 Å (methyl). All non-hydrogen atoms were refined anisotropically. Scattering factors and anomalous dispersion corrections are taken from A. J. C. Wilson (ed),

[0213] International Tables for X-ray Crystallography, Volume C. Kynoch, Academic Publishers, Dordrecht, 1992, Tables 6.1.1.4 (pp. 500-502) and 4.2.6.8 (pp. 219-222) the International Tables for X-ray Crystallography. Structure solution, refinement, graphics and generation of publication materials were performed by using SHELXTL, V5.10 software. Additional details of data collection and structure refinement are given in Table 4 which follows.

EXAMPLE 5

Crystal Structure Analysis of fluoxetine HCl:succinic Acid Cocrystal (2:1)

[0214] A suitable cocrystal of fluoxetine HCl-succinic acid (2:1) was coated with Paratone N oil, suspended in a small fiber loop and placed in a cooled nitrogen gas stream at 100 K on a Bruker D8 SMART APEX CCD sealed tube diffractometer with graphite monochromated MoKα (0.71073A) radiation. Data were measured using a series of combinations of phi and omega scans with 10 second frame exposures and 0.3° frame widths. Data collection, indexing and initial cell refinements were all carried out using SMART software (SMART Version 5.624, 2000, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). Frame integration and final cell refinements were done using SAINT software (SAINT Version 6.02, 2000, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). The final cell parameters were determined from least-squares refinement on 5435 reflections. The SADABS program was used to carry out absorption corrections (SADABS Version 2.03, 2001, George Sheldrick, University of Göttingen).

[0215] The structure was solved using Direct methods and difference Fourier techniques (SHELXTL V5.10, 2000, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). Hydrogen atoms were placed their expected chemical positions using the HFIX command and were included in the final cycles of least squares with isotropic Uij's related to the atom's ridden upon. The C—H distances were fixed at 0.93 Å (aromatic and amide), 0.98 Å (methine), 0.97 Å (methylene), or 0.96 Å (methyl). All non-hydrogen atoms were refined anisotropically. Scattering factors and anomalous dispersion corrections are taken from A. J. C. Wilson (ed), International Tables for X-ray Crystallography, Volume C. Kynoch, Academic Publishers, Dordrecht, 1992, Tables 6.1.1.4 (pp. 500-502) and 4.2.6.8 (pp. 219-222). Structure solution, refinement, graphics and generation of publication materials were performed by using SHELXTL, V5.10 software. Additional details of data collection and structure refinement are given in Table 5 which follows.

EXAMPLE 6

Crystal Structure Analysis of Nabumetone: 2,3-naphthalenediol Cocrystal (1:1)

[0216] A suitable cocrystal of nabumetone:2,3-naphthalenediol (1:1) was coated with Paratone N oil, suspended in a small fiber loop and placed in a cooled nitrogen gas stream at 100 K on a Bruker D8 SMART 1000 CCD sealed tube diffractometer with graphite monochromated CuKα (1.54178 Å) radiation. Data were measured using a series of combinations of phi and omega scans with 10 second frame exposures and 0.3° frame widths. Data collection, indexing and initial cell refinements were all carried out using SMART software (SMART Version 5.55, 2000, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). Frame integration and final cell refinements were done using SAINT software (SAINT Version 6.02, 1999, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). The final cell parameters were determined from least-squares refinement on 2869 reflections.

[0217] The structure was solved using Direct methods and difference Fourier techniques (SHELXTL V5.10, 1997, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). Hydrogen atoms were placed their expected chemical positions using the HFIX command and were included in the final cycle's of least squares with isotropic Uij's related to the atom's ridden upon. The C—H distances were fixed at 0.93 Å (aromatic and amide), 0.98 Å (methine), 0.97 Å (methylene), or 0.96 Å (methyl). All non-hydrogen atoms were refined anisotropically. Scattering factors and anomalous dispersion corrections are taken from A. J. C. Wilson (ed), International Tables for X-ray Crystallography, Volume C. Kynoch, Academic Publishers, Dordrecht, 1992, Tables 6.1.1.4 (pp. 500-502) and 4.2.6.8 (pp. 219-222). Structure solution, refinement, graphics and generation of publication materials were performed by using SHELXTL, V5.10 software. Additional details of data collection and structure refinement are given in Table 6 which follows.

EXAMPLE 7

Cocrystals of Active Agent Salts and Guests

[0218] The experiments of Examples 1 and 2 are repeated, using conditions similar to those of those previous Examples, with each possible combination of the salts of active agents and guests identified earlier in this disclosure. Cocrystals are formed which have utility according to the known activity of the active agent.

EXAMPLE 8

Cocrystals of Active Agents and Guest Salts

[0219] The experiments of Example 3 are repeated, using conditions similar to those of those previous Examples, with each possible combination of the neutral or zwitterionic active agents and guest salts identified earlier in this disclosure. Cocrystals are formed which have utility according to the known activity of the active agent.

EXAMPLE 9

Cocrystallization of Fluoxetine HCl and Fumaric Acid

[0220] Cocrystals of fluoxetine HCl and succinic acid were prepared as follows. A 6.00 g sample of fluoxetine HCl and 1.01 g of fumaric acid were dissolved in 20 mL of ethanol with heating. The solution was filtered through a 0.2 μm nylon filter, concentrated to a volume of 8 mL, and cooled in an ice bath for 6 hours. The solid material was isolated on filter paper and allowed to dry in the air to give 5.74 g (82% yield) of fluoxetine HCl:fumaric acid (2:1) cocrystal. The measured melting points were 158° C. for fluoxetine HCl, >300° C. (decomposes) for fumaric acid, and 164° C. for the cocrystal. The cocrystal is expected to have a good toxicology profile, since fumaric acid is known to be safe and appears on the Generally Recognized As Safe (“GRAS”) list from the U.S. Food and Drug Administration.

EXAMPLE 10

Crystal Structure Analysis of fluoxetine HCl:fumaric Acid Cocrystal (2:1)

[0221] A suitable cocrystal of fluoxetine HCl and fumaric acid was coated with Paratone N oil, suspended in a small fiber loop and placed in a cooled nitrogen gas stream at 100 K on a Bruker D8 SMART 1000 CCD sealed tube diffractometer with graphite monochromated CuKα (1.54178 Å) radiation. Data were measured using a series of combinations of phi and omega scans with 10 second frame exposures and 0.3° frame widths. Data collection, indexing and initial cell refinements were all carried out using SMART software (SMART Version 5.55, 2000, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). Frame integration and final cell refinements were done using SAINT software (SAINT Version 6.02, 1999, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). The final cell parameters were determined from least-squares refinement on 5625 reflections.

[0222] The structure was solved using Direct methods and difference Fourier techniques (SHELXTL V5.10, 1997, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). All the hydrogen atoms were located from difference Fouriers and included in the final cycles of least squares with isotropic Uij's. All non-hydrogen atoms were refined anisotropically. Scattering factors and anomalous dispersion corrections are taken from A. J. C. Wilson (ed), International Tables for X-ray Crystallography, Volume C. Kynoch, Academic Publishers, Dordrecht, 1992, Tables 6.1.1.4 (pp. 500-502) and 4.2.6.8 (pp. 219-222). Structure solution, refinement, graphics and generation of publication materials were performed by using SHELXTL, V5.10 software. Additional details of data collection and structure refinement are given in Table G which follows.

[0223] All patents, test procedures, and other documents cited herein, including priority documents, are fully incorporated by reference to the extent such disclosure is not inconsistent with this invention and for all jurisdictions in which such incorporation is permitted.

[0224] While the present invention has been described and illustrated by reference to particular embodiments, it will be appreciated by those of ordinary skill in the art that the invention lends itself to many different variations not illustrated herein. For these reasons, then, reference should be made solely to the appended claims for purposes of determining the true scope of the present invention.

[0225] Although the appendant claims have single appendencies in accordance with U.S. patent practice, each of the features in any of the appendant claims can be combined with each of the features of other appendant claims or the main claim.

TABLE 1
10-camphorsulfonic acid
10-undecylenic acid
1-hydroxy-2-naphthoic acid
2,4-dihydroxybenzoic acid
2,5-dihydroxybenzoic acid
2-aminopropionic acid
2-ethylbutyrinc acid
2-furancarboxylic acid
2-mercaptobenzoic acid
3-methylbutanoic acid
3-phenylpropionic acid
4-aminobenzoic acid
4-aminosalicylic acid
4-hydroxybenzoic acid
adipic acid
alginic acid
anisic acid
arginine
ascorbic acid
asparagine
aspartic acid
aspirin
benzenesulfonic acid
benzoic acid
4-acetamidobenzoic acid
beta-alanine
camphoric acid
camphorsulfonic acid
carbonic acid
cholic acid
cinnamic acid
citric acid
cyclamic acid
cyclohexanecarboxylic acid
cyclohexylacetic acid
cysteine
diphenylacetic acid
dodecylsulfonic acid
ethane-1,2-disulfonic acid
ethanesulfonic acid
ethanesulfonic acid, 2-hydroxy
ethylenediaminetetraacetic acid
ethylsulfuric acid
fumaric acid
galactaric acid
gallic acid
gentisic acid
glucoheptonic acid
gluconic acid
glutamic Acid
glutamine
glutaric acid
glutaric acid, 2-oxo-
glycine
glycolic acid
hippuric acid
histidine
hydroxyproline
isoleucine
lactobionic acid
lauric acid
leucine
levulinic acid
lysine
maleic acid
malic acid
malonic acid
mandelic acid
m-methoxybenzoic acid
naphthalene-1,5-disulfonic acid
naphthalene-2-sulfonic acid
n-decanoic acid
niacin
nicotinic acid
n-tetradecanoic acid
oleic acid
o-methylbenzoic acid
orotic acid
orthoboric acid
o-toluic acid
p-acetamidobenzoic acid
palmitic acid
pamoic acid
phenoxyacetic acid
phenylacetic acid
phenylalanine
picric acid
pivalic acid
proline
p-toluenesulfonic acid
pyroglutamic acid
pyruvic acid
salicylic acid
sebacic acid
serine
sorbic acid
stearic acid
succinic acid
sulfosalicylic acid
tartaric acid
terephthalic acid
thiocyanic acid
threonine
tiglic acid
tryptophan
tyrosine
valeric acid
valine

[0226]

TABLE 2
Name                            CAS #
Potassium bicarbonate           298-14-6
Potassium carbonate             584-08-7
Potassium chloride              7447-40-7
Potassium hydroxide             1310-58-3
Potassium metabisulfite         16731-55-8
Potassium nitrate               7757-79-1
Potassium nitrite               7758-09-0
Potassium permanganate          7722-64-7
Potassium persulfate            7727-21-1
Potassium phosphate, dibasic    2139900
Potassium Phosphate Monobasic   7778-77-0
potassium phosphate, tribasic,  7778-53-2
n-hydrate
Potassium sulfate               7778-80-5
Sodium bicarbonate              144-55-8
Sodium bisulfite                7631-90-5
Sodium borohydride              16940-66-2
Sodium carbonate                497-19-8
Sodium Carbonate Monohydrate    1486118
Sodium chloride                 7647-14-5
Sodium dithionite               7775-14-6
Sodium fluoride                 7681-49-4
Sodium hexametaphosphate        10124-56-8
Sodium hydroxide                1310-73-2
Sodium hypochlorite             7681-52-9
Sodium Metabisulfite            7681-57-4
Disodium metasilicate           6834-92-0
sodium monophosphate            7681-53-0
Sodium nitrate                  7631-99-4
Sodium nitrite                  7632-00-0
sodium hydrogen phosphate       7558-79-4
Sodium Phosphate Monobasic      7558-80-7
Sodium Pyrophosphate            7722-88-5
Sodium silicate                 1344-09-8
Sodium Sulfate Decahydrate      7727-73-3
Sodium sulfite                  7757-83-7
Sodium Thiosulfate              10102-17-7
Pentahydrate
Calcium acetate                 5743-26-0
Calcium Carbonate               471-34-1
Calcium Chloride Dihydrate      10035-04-8
Calcium gluconate               299-28-5
Calcium hydroxide               1305-62-0
Calcium oxide                   1305-78-8
Calcium phosphate, dibasic      7757-93-9
Calcium Phosphate Monobasic     7758-23-8
Calcium sulfate                 7778-18-9
Magnesium hydroxide             1309-42-8
Magnesium Sulfate Heptahydrate  10034-99-8
Aluminum                        7429-90-5
Aluminum ammonium sulfate       7784-26-1
Aluminum chloride               7446-70-0
Aluminum hydroxide              21645-51-2
Aluminum potassium sulfate,     7784-24-9
dodecahydrate
Orthoboric acid                 10043-35-3
formaldehyde                    50-00-0
DL-Isoleucine                   443-79-8
(2S,7S)-(−)-Cystine             56-89-3
DL-Alanine                      302-72-7
beta-Alanine                    107-95-9
(S)-(+)-Arginine                74-79-3
(S)-(−)-Cysteine                52-90-4
DL-Glutamic acid                617-65-2
Glycine                         56-40-6
(S)-(−)-Histidine               71-00-1
(S)-(+)-Lysine                  56-87-1
DL-Methionine                   59-51-8
DL-Phenylalanine                150-30-1
(S)-(−)-Phenylalanine           63-91-2
D-(+)-Proline                   344-25-2
(S)-(−)-Tryptophan              73-22-3
(S)-(−)-Tyrosine                60-18-4
Carvone                         99-49-0
Citral                          5392-40-5
Ethyl butyrate                  105-54-4
Isobutyl propionate             540-42-1
Methyl butyrate                 623-42-7
n-Propyl acetate                109-60-4
Isobutyl formate                542-55-2
Benzyl acetate                  140-11-4
6-Methyl-5-hepten-2-one         110-93-0
Butyl acetate                   123-86-4
Ethyl acetoacetate              141-97-9
Isopentyl Acetate               123-92-2
Cinnamaldehyde                  104-55-2
Methyl benzoate                 93-58-3
Butyl sulfide                   544-40-1
Ethyl benzoate                  93-89-0
2,4-Hexadienoic acid,           24634-61-5
potassium salt, (E,E)-
Potassium bitartrate            868-14-4
Lauric acid                     143-07-7
Benzyl benzoate                 120-51-4
Picric acid                     88-89-1
Benzoyl peroxide                94-36-0
Palmitic acid                   57-10-3
Dibutyl phthalate               84-74-2
Stearic acid                    57-11-4
Succinic anhydride              108-30-5
Diethylenetriamine              111-40-0
Diethanolamine                  111-42-2
Benzaldehyde                    100-52-7
Phenethylamine                  64-04-0
Salicylylaldehyde               90-02-8
Sodium benzoate                 532-32-1
Cinnamic acid                   621-82-9
Triethanolamine                 102-71-6
L-(+)-Tartaric Acid             87-69-4
Eugenol                         97-53-0
D-mannitol                      69-65-8
Butyl paraben                   94-26-8
Benzoin                         119-53-9
Diethyl phthalate               84-66-2
Oleic acid                      112-80-1
Sodium lactate                  72-17-3
Indole                          120-72-9
ethyl lactate                   97-64-3
quinoline                       91-22-5
Thymol                          89-83-8
Methyl anthranilate             134-20-3
Methyl salicylate               119-36-8
Diethyl malonate                105-53-3
Citric acid                     77-92-9
Sodium dodecyl sulfate          151-21-3
Morpholine                      110-91-8
Furfural                        98-01-1
Niacin                          59-67-6
Choline chloride                67-48-1
L-Menthol                       2216-51-5
Meso-inositol                   87-89-8
ethylenediaminetetraacetic      60-00-4
acid
EDTA, calcium derivative,       62-33-9
disodium salt
Calcium pantothenate            137-08-6
Riboflavin                      83-88-5
Zinc carbonate                  3486-35-9
Amyl alcohol                    71-41-0
Mineral oil                     8012-95-1
Triton(R) X-100                 9002-93-1
Acetaldehyde                    75-07-0
Acetic Acid                     64-19-7
Acetone                         67-64-1
Acetophenone                    98-86-2
4-Aminobenzoic acid             150-13-0
Anisole                         100-66-3
Vitamin C                       50-81-7
Benzoic Acid                    65-85-0
Biphenyl                        92-52-4
2-Methyl-1-propanol             78-83-1
n-Butanol                       71-36-3
n-Butylamine                    109-73-9
ethyl acetate                   141-78-6
Caffeine                        58-08-2
Chloroacetic Acid               79-11-8
Dichloroacetic Acid             79-43-6
Diethylamine                    109-89-7
Ethanol Amine                   141-43-5
n-Butyric Acid                  107-92-6
Ethylenediamine                 107-15-3
Formic acid                     64-18-6
n-Hexanol                       111-27-3
Methanol                        67-56-1
Methyl Acetate                  79-20-9
Methyl 4-hydroxybenzoate        99-76-3
m-Cresol                        108-39-4
p-Cresol                        106-44-5
Phenol                          108-95-2
n-Propanol                      71-23-8
Propionic Acid                  79-09-4
Salicylic acid                  69-72-7
Sucrose                         57-50-1
Vanillin                        121-33-5
Vitamin E                       59-02-9
Potassium citrate, monohydrate  1534146
p-toluenesulfonic acid          6192-52-5
monohydrate
D-(+)-Maltose                   69-79-4
Tetrasodium                     64-02-8
ethylenediaminetetraacetate
Saccharin sodium                128-44-9
Sodium Acetate Trihydrate       6131-90-4
Quinine sulfate, dihydrate      6119-70-6
Sulfosalicylic acid, dihydrate  5965-83-3
L-(+)-Arginine                  1119-34-2
monohydrochloride
Procaine hydrochloride          51-05-8
Pyridoxine Hydrochloride        58-56-0
Thiamine hydrochloride          67-03-8
Propionaldehyde                 123-38-6
Urea                            57-13-6
2-Propanol                      67-63-0
Pyrrole                         109-97-7
Sodium formate                  141-53-7
Pyrrolidine                     123-75-1
Methyl ethyl ketone             78-93-3
Ethyl formate                   109-94-4
Propylene glycol                57-55-6
Thiourea                        62-56-6
Ammonium acetate                631-61-8
Benzene                         71-43-2
Sodium acetate                  127-09-3
Cyclopentanone                  120-92-3
Cyclohexane                     110-82-7
piperidine                      110-89-4
2-Pentanone                     107-87-9
hexane                          110-54-3
Isoamyl Alcohol                 123-51-3
Lactic acid                     50-21-5
2-Ethoxyethanol                 110-80-5
Propionic acid, sodium salt     137-40-6
Potassium acetate               127-08-2
cyclohexyl amine                108-91-8
methyl methacrylate             80-62-6
methyl isobutyl ketone          108-10-1
Acetic anhydride                108-24-7
Isopropyl Acetate               108-21-4
2,2′-Oxybisethanol              111-46-6
Benzyl alcohol                  100-51-6
Resorcinol                      108-46-3
2-Butoxy ethanol                111-76-2
Cumene                          98-82-8
2-Amino-2-(hydroxymethyl)-1,3-  77-86-1
propanediol
Phenethyl alcohol               60-12-8
2-Ethyl-1-hexanol               104-76-7
2-Octanol                       123-96-6
2-(2-Ethoxyethoxy) ethanol      111-90-0
2,6-Dimethyl-4-heptanone        108-83-8
Benzophenone                    119-61-9
D-(−)-Fructose                  57-48-7
D-Glucose                       50-99-7
D-Ribose                        50-69-1
D-(+)-Xylose                    58-86-6
Pectin sugar                    5328-37-0
D-(+)-Lactose                   63-42-3
Camphene                        79-92-5
Isoquinoline                    119-65-3
2,4-Dimethylphenol              105-67-9
2,5-Dimethylphenol              95-87-4
2,6-Dimethylphenol              576-26-1
Methanesulfonic Acid            75-75-2
o-Methoxybenzoic Acid           579-75-9
Saccharin                       81-07-2
Thiazole                        288-47-1
Trifluoromethanesulfonic Acid   1493-13-6
Trimethylamine                  75-50-3
Coumarin                        91-64-5
Dimethylamine                   124-40-3
Ethyl Alcohol                   64-17-5
Butyl benzyl phthalate          85-68-7
2,6-dimethylpyrazine            108-50-9
taurocholic acid                81-24-3
geraniol                        106-24-1
linalool                        78-70-6
ethyl isovalerate               108-64-5
ethyl 2-methylbutyrate          7452-79-1
1-octen-3-ol                    3391-86-4
ethyl 2-trans-4-cis-            3025-30-7
decadienoate
Dihydromyrcenol                 18479-58-8
citronellal                     106-23-0
linalyl acetate                 115-95-7
8-mercapto-p-menthan-3-one      38462-22-5
Ammonium citrate                3012-65-5
Ammonium bicarbonate            1066-33-7
Ammonium chloride               12125-02-9
Ammonium hydroxide              1336-21-6
Ammonium persulfate             7727-54-0
Ammonium phosphate, dibasic     7783-28-0
Ammonium Phosphate Monobasic    7722-76-1
Ammonium sulfate                7783-20-2
Ammonium sulfide                12135-76-1
Hydrazine                       302-01-2
Nitric acid                     7697-37-2
phosphoric acid                 7664-38-2
Phosphorus oxychloride          10025-87-3
Hydriodic acid                  10034-85-2
Hydrobromic acid                10035-10-6
Hydrochloric acid               7647-01-0
hydrogen peroxide               7722-84-1
Periodic Acid                   10450-60-9
Sulfamic acid                   5329-14-6
Sulfuric acid                   7664-93-9
Sulfurous acid                  7782-99-2
Dexpanthenol                    81-13-0
4-oxoisophorone                 1125-21-9
Copper(II) sulfate              7758-98-7
ferric chloride                 7705-08-0
Ferric oxide                    1309-37-1
ferric sulfate                  10028-22-5
Iron (II) Sulfate Heptahydrate  7782-63-0
Iron                            7439-89-6
Manganese (II) Sulfate          10034-96-5
Monohydrate
Nickel                          7440-02-0
Titanium dioxide                13463-67-7
Zinc chloride                   7646-85-7
Zinc oxide                      1314-13-2
1,1′-Azobisformamide            123-77-3
1,3-Butanediol                  107-88-0
1-Methylnaphthalene             90-12-0
2,6-Di-tert-Butyl-p-Cresol      128-37-0
2,6-Dimethylpyridine            108-48-5
Disodium                        138-93-2
cyanodithioimidocarbonate
3-Methyl-2-Cyclopentene-2-ol-   80-71-7
one
6-Methylcoumarin                92-48-8
acetoin                         513-86-0
alpha-Phellandrene              99-83-2
alpha-Terpinene                 99-86-5
Benzenesulfonic Acid            98-11-3
Benzothiazole                   95-16-9
borates, tetrasodium salts      1330-43-4
Butyl butyrate                  109-21-7
Butyl Mercaptan                 109-79-5
Butyraldehyde                   123-72-8
Capsaicin                       404-86-4
Chloromethyl Methyl Ether       107-30-2
Cymene                          99-87-6
Diallyl Disulfide               2179-57-9
Diethylaminoethanol             100-37-8
dimethyldisulfide               624-92-0
Dimethyl Succinate              106-65-0
Dimethyl Sulfate                77-78-1
Dimethyl Sulfide                75-18-3
Dipropyl Disulfide              629-19-6
Dipropyl Ketone                 123-19-3
Ethyl Acrylate                  140-88-5
Ethyl Butyl Ketone              106-35-4
Ethyl Propionate                105-37-3
Furfuryl Alcohol                98-00-0
gamma-Butyrolactone             96-48-0
Glutaraldehyde                  111-30-8
glycerin                        56-81-5
Glycolic Acid                   79-14-1
Isobutyl Acetate                110-19-0
Isobutyl Isobutyrate            97-85-8
Isobutyraldehyde                78-84-2
Isoheptanol                     543-49-7
Isophorone                      78-59-1
Isopropyl Mercaptan             75-33-2
Methyl isobutenyl ketone        141-79-7
Methyl n-amyl ketone            110-43-0
methyl acrylate                 96-33-3
Methyl Isobutyrate              547-63-7
Methyl Mercaptan                74-93-1
N,N-Dimethylethanolamine        108-01-0
n-Butyl Lactate                 138-22-7
n-Hexyl Acetate                 142-92-7
n-Valeraldehyde                 110-62-3
Nitrous Oxide                   10024-97-2
p-Anisaldehyde                  123-11-5
2-Methylcyclohexanone           583-60-8
Octanoic Acid                   124-07-2
Oxalic Acid                     144-62-7
Phenyl ether                    101-84-8
Phenylmercaptan                 108-98-5
Propargyl Alcohol               107-19-7
Propyl paraben                  94-13-3
sec-Butyl Alcohol               78-92-2
Sodium Gluconate                527-07-1
Sodium Tripolyphosphate         7758-29-4
Tetrahydro-2-furanmethanol      97-99-4
Valeric Acid                    109-52-4
3,4-xylenol                     95-65-8
3-hexanol                       623-37-0
3-methyl-1-pentanol             589-35-5
1,1-diethoxyethane              105-57-7
Aluminum Sulfate                10043-01-3
ammonium sulfite                10196-04-0
amyl butyrate                   540-18-1
borneol                         507-70-0
butyl formate                   592-84-7
calcium peroxide                1305-79-9
n-Hexanoic Acid                 142-62-1
cyclohexyl acetate              622-45-7
diacetyl                        431-03-8
dimethyl carbonate              616-38-6
ethyl butyraldehyde             97-96-1
Ethyl crotonate                 623-70-1
ethyl isobutyrate               97-62-1
ethyl nitrite                   109-95-5
fumaric acid                    110-17-8
hexaldehyde                     66-25-1
isobutyric acid                 79-31-2
methyl isovalerate              556-24-1
methyl propionate               554-12-1
methyl valeraldehyde            123-15-9
nitrosyl chloride               2696-92-6
octafluorocyclobutane           115-25-3
peroxyacetic acid               79-21-0
propyl formate                  110-74-7
propyl mercaptan                107-03-9
Sodium aluminate                1302-42-7
sodium chlorite                 7758-19-2
Terephthalic Acid               100-21-0
allyl isothiocyanate            57-06-7
Vitamin B1                      59-43-8
Valproic acid                   99-66-1
Ethoxyquin                      91-53-2
n-Amyl Ethyl Ketone             106-68-3
Nabam                           142-59-6
Sodium sulfide                  1313-82-2
Thiocyanic acid                 463-56-9
2-Methyl-5-(1-methylethenyl)-   2244-16-8
2-cyclohexene-1-one
4-(2,6,6-Trimethyl-2-           127-41-3
cyclohexen-1-yl)-3-buten-2-one
4-(2,6,6-trimethyl-1-           14901-07-6
cyclohexen-1-yl)-3-buten-2-one
Isoamyl propionate              105-68-0
3-Methylbutanoic acid           503-74-2
L-Menthone                      14073-97-3
4-Ethylphenol                   123-07-9
o-cresol                        95-48-7
dimethyl-Carbamodithioic acid,  128-04-1
sodium salt
Anethole                        104-46-1
Dimethyl terephthalate          120-61-6
propyl gallate                  121-79-9
L-Ascorbic Acid Sodium Salt     134-03-2
4-Hexylresorcinol               136-77-6
Estragole                       140-67-0
L-monosodium glutamate          142-47-2
Malonaldehyde, sodium salt      24382-04-5
Butylated hydroxyanisole        25013-16-5
allyl 3-methylbutyrate          2835-39-4
DL-monosodium glutamate         32221-81-1
3-Acetyl-6-methyl-2,4-          520-45-6
pyrandione
L-Glutamic Acid                 56-86-0
DL-alpha-tocopheryl acetate     58-95-7
D-limonene                      5989-27-5
Calcium Acetate                 62-54-4
Erythorbic Acid Monosodium      6381-77-7
Salt
Ethyl methylphenylglycidate     77-83-8
2,4,6-Trinitro-1,3-dimethyl-5-  81-15-2
tert-butylbenzene
Dimethoxane                     828-00-2
3,5-Di-tert-butyl-4-            88-26-6
hydroxybenzyl alcohol
6-Methylquinoline               91-62-3
alpha-Methylbenzyl alcohol      98-85-1
Nicotinamide                    98-92-0
3,4-Dihydrocoumarin             119-84-6
Geranyl Acetate                 105-87-3
Sodium (2-Ethylhexyl)Alcohol    126-92-1
Sulfate
Cyclohexanol, 5-methyl-2-(1-    89-78-1
methylethyl)-,
(1alpha,2beta,5alpha)-
(+)-Camphor                     464-49-3
(1S)-(−)-alpha-Pinene           7785-26-4
1,3-Dihydroxy-5-methylbenzene   504-15-4
1,5-Naphthalenedisulfonic Acid  1655-29-4
Disodium Salt
1-Hydroxy-2-naphthoic Acid      86-48-6
1-Penten-3-ol                   616-25-1
1-Phenyl-1-propanol             93-54-9
10-Undecylenic Acid             112-38-9
2′-Hydroxyacetophenone          118-93-4
2,4-Dihydroxybenzoic Acid       89-86-1
2-Acetylfuran                   1192-62-7
2-Furancarboxylic Acid          88-14-2
2-Isopropylphenol               88-69-7
2-Ketoglutaric Acid             328-50-7
2-Ketovaline                    759-05-7
2-n-Propylphenol                644-35-9
2-Naphthalenethiol              91-60-1
2-Phenyl-1-propanol             1123-85-9
3,3′-Thiodipropionic Acid       111-17-1
3,5,5-Trimethylhexanal          5435-64-3
3-Phenyl-1-propanol             122-97-4
3-Phenylpropionic Acid          501-52-0
4-Aminosalicylic Acid           65-49-6
4-Ethoxyphenol                  622-62-8
4-Hydroxybenzoic Acid           99-96-7
4-Phenyl-2-butanol              2344-70-9
4-tert-Octylphenol              140-66-9
Allyl Cinnamate                 1866-31-5
Allyl Mercaptan                 870-23-5
alpha-L-Rhamnose                3615-41-6
Alpha-Terpineol                 98-55-5
Anisic Acid                     100-09-4
Benzalacetone                   122-57-6
Benzaldehyde Dimethylacetal     1125-88-8
Benzyl Ether                    103-50-4
Benzyl Formate                  104-57-4
Benzyl Mercaptan                100-53-8
Benzyl Salicylate               118-58-1
Calcium Citrate                 813-94-5
Calcium Glycerophosphate        27214-00-2
Calcium Hypophosphite           7789-79-9
Calcium Iodate                  7789-80-2
Propanoic acid, 2-hydroxy-,     814-80-2
calcium salt (2:1)
Calcium Phosphate Tribasic      7758-87-4
Calcium Propionate              4075-81-4
Calcium Pyrophosphate           7790-76-3
Cholic Acid                     81-25-4
Choline                         123-41-1
Choline Bitartrate              87-67-2
trans-Cinnamic Aldehyde         14371-10-9
Cinnamyl Alcohol                104-54-1
Citronellol                     106-22-9
Copper(I)Iodide                 7681-65-4
D-(+)-Glucono-1,5-lactone       90-80-2
D-(−)-Tartaric Acid             147-71-7
D-Isoascorbic Acid              89-65-6
D-Tyrosine                      556-02-5
Sodium dehydroacetate           4418-26-2
Deoxycholic Acid                83-44-3
Dibenzyl Ketone                 102-04-5
Diethyl L-(+)-Tartrate          87-91-2
Diethyl Succinate               123-25-1
Dimethylacetal                  534-15-6
DL-Cystine                      923-32-0
DL-Proline                      609-36-9
DL-Tartaric Acid                133-37-9
DL-Tyrosine                     556-03-6
DL-Valine                       516-06-3
Enanthoic Acid                  111-14-8
Erythorbic Acid Sodium Salt     7378-23-6
Ethyl 2-Aminobenzoate           87-25-2
Ethyl Cinnamate                 103-36-6
Ethyl n-Valerate                539-82-2
Ethyl Phenylacetate             101-97-3
Ethyl Salicylate                118-61-6
Ethyl Sulfide                   352-93-2
Ethyl Vanillin                  121-32-4
Ethylene Mercaptan              540-63-6
Farnesene                       502-61-4
Folic acid                      59-30-3
gamma-Nonanolactone             104-61-0
gamma-Valerolactone             108-29-2
Gluconic Acid                   526-95-4
Gluconic Acid Potassium Salt    299-27-4
Glutaric Acid                   110-94-1
Guanosine-5′-monophosphate,     1333479
disodium salt
Heliotropine                    120-57-0
Hippuric Acid                   495-69-2
Hydroquinone Dimethyl Ether     150-78-7
Inosine-5′-monophosphate        4691-65-0
Sodium Salt
iso-Amyl Mercaptan              541-31-1
Isoamyl Salicylate              87-20-7
iso-Butyl n-Hexanoate           105-79-3
isovaleraldehyde                590-86-3
Isoamyl Benzoate                94-46-2
Isoamyl Formate                 110-45-2
Isoamyl n-Butyrate              106-27-4
Isoamylamine                    107-85-7
Isobutyl n-Butyrate             539-90-2
Isocaproic Acid                 646-07-1
Isoeugenol                      97-54-1
Isopropyl Benzoate              939-48-0
Isopropyl Formate               625-55-8
Isopropyl N-Butyrate            638-11-9
Isopropyl Propionate            637-78-5
isobutyl Mercaptan              513-44-0
L-(+)-Isoleucine                73-32-5
L-(−)-Apple Acid                97-67-6
L-2-Aminopropionic Acid         56-41-7
L-Aspartic acid                 56-84-8
L-Carnitine                     541-15-1
L-Cysteine Hydrochloride        52-89-1
L-Glutamic Acid Hydrochloride   138-15-8
L-Glutamine                     56-85-9
L-Hydroxyproline                51-35-4
L-Proline                       147-85-3
L-Serine                        56-45-1
L-Threonine                     72-19-5
L-Valine                        72-18-4
N-Acetylglycine                 543-24-8
n-Amyl Formate                  638-49-3
n-Amyl n-Caproate               540-07-8
n-Butyl n-Caproate              626-82-4
n-Butyl Propionate              590-01-2
n-Butyl Salicylate              2052-14-4
n-Decanoic Acid                 334-48-5
n-Hexyl Mercaptan               111-31-9
n-Propyl Benzoate               2315-68-6
n-Propyl Isobutyrate            644-49-5
n-Tetradecanoic Acid            544-63-8
Nitrilotriacetic Acid           5064-31-3
Trisodium Salt
o-Toluenethiol                  137-06-4
Orotic Acid                     65-86-1
p-Acetamidobenzoic Acid         556-08-1
p-Anise Alcohol                 105-13-5
Phenoxyacetic Acid              122-59-8
Phenyl Acetate                  122-79-2
Piperine                        94-62-2
Pivalic Acid                    75-98-9
Potassium Benzoate              582-25-2
Potassium Diphosphate           7320-34-5
Potassium Hypophosphite         7782-87-8
Potassium Metaphosphate         7790-53-6
Potassium Sulfite               10117-38-1
Quinine Hydrochloride           130-89-2
sec-Amyl Alcohol                6032-29-7
Sodium D-Pantothenate           867-81-2
Di(2-ethylhexyl) sulfosuccinic  577-11-7
acid, sodium salt
Sodium Sorbate                  7757-81-5
Succinic acid, disodium salt    150-90-3
Sodium Taurocholate             145-42-6
Taurine                         107-35-7
Thiamine Nitrate                532-43-4
Thioanisole                     100-68-5
Tiglic Acid                     80-59-1
Tri-n-butyrin                   60-01-5
Triacetin                       102-76-1
Trisodium Citrate               68-04-2
Veratraldehyde                  120-14-9
Veratrole                       91-16-7
Vitamin P                       520-26-3
Vitamin U Chloride              582174
L-methionine                    63-68-3
2-Chloro-1-propanol             78-89-7
2-Ethylbutyric acid             88-09-5
2-Methylbutyraldehyde           96-17-3
2-Methyl-5-ethylpyridine        104-90-5
n-propyl butyrate               105-66-8
Ethyl caprylate                 106-32-1
Propyl propionate               106-36-5
2-Methylpyrazine                109-08-0
3,3,5-Trimethyl-1-cyclohexanol  116-02-9
Ethyl caproate                  123-66-0
o-methoxybenzaldehyde           135-02-4
2,4-Hexadienal                  142-83-6
3-Hexanone                      589-38-8
3-Methyl-2-butanol              598-75-4
Methyl isopropenyl ketone       814-78-8
3-Methyl-2-butanethiol          2084-18-6
3,5,5-Trimethylhexanol          3452-97-9
Methylglyoxal                   78-98-8
Malonaldehyde                   542-78-9
1,4-Dithiane                    505-29-3
Amylcinnamaldehyde              122-40-7
Benzyl cinnamate                103-41-3
tert-Butylhydroquinone          1948-33-0
Fusidic Acid Sodium Salt        751-94-0
Hydroxycitronellal              107-75-5
Musk ketone                     81-14-1
L-Asparagine                    70-47-3
phenethyl acetate               103-45-7
Riboflavin-5-Phosphate          146-17-8
Potassium Sodium Tartrate       304-59-6
Galactaric acid                 526-99-8
Sodium Tartrate                 868-18-8
trisodium phosphate             7601-54-9
Disodium Pytophosphate          7758-16-9
Magnesium chloride              7786-30-3
Sodium Polymethacrylate         54193-36-1
propiophenone                   93-55-0
2-ethylhexanoic acid            149-57-5
3,7,7-trimethyl bicyclohep-3-   13466-78-9
ene
2,6-dimethyl-4-heptanol         108-82-7
5-isopropyl-2-methyl-phenol     499-75-2
L-Bornyl acetate                5655-61-8
caryophyllene                   87-44-5
hydroxymethylpyrone             118-71-8
neosperidin dihydrochalcone     20702-77-6
2,2-Dibromo-3-                  10222-01-2
nitrilopropionamide
Xylitol                         87-99-0
Sulfosalicylic acid             97-05-2
Riboflavin 5′-(dihydrogen       130-40-5
phosphate), monosodium salt
Ethylenediaminetetraacetic      139-33-3
acid, disodium salt
Gallic acid                     149-91-7
Carbonic acid                   463-79-6
Potassium carbonate,            6381-79-9
sesquihydrate
Magnesium phosphate tribasic    7757-87-1
diallyl sulfide                 592-88-1
ethyl 4-oxopentanoate           539-88-8
methyl caproate                 106-70-7
isopropyl isobutyrate           617-50-5
diethyl hydroxybutanedioate     2065419
propyl isopentanoate            557-00-6
benzyl ethyl ether              539-30-0
isobutyl isopentanoate          589-59-3
propyl hexanoate                626-77-7
4-methylquinoline               491-35-0
methyl cinnamate                103-26-4
cumic alcohol                   536-60-7
thujone                         471-15-8
dihydrocarveol                  619-01-2
fenchyl alcohol                 1632-73-1
Nerol                           106-25-2
isopentyl isopentanoate         659-70-1
methyleugenol                   93-15-2
methyl 2-naphthyl ketone        93-08-3
diphenyldisulfide               882-33-7
citronellyl acetate             150-84-5
menthyl acetate                 89-48-5
menthyl isovalerate             16409-46-4
5-Ethyl-3-hydroxy-4-methyl-     698-10-2
2(5H)-furanone
malic acid                      6915-15-7
3-methylbutanoic acid butyl     109-19-3
ester
3-phenyloxiranecarboxylic acid  121-39-1
ethyl ester
1,2-Benzisothiazol-3(2H)-one    6381-61-9
1,1-dioxide, ammonium salt
1-methyl-4-(1-methylethyl)-     99-85-4
1,4-Cyclohexadiene
3-mercapto-2-Butanol            54812-86-1
(1R)-2,6,6-                     7785-70-8
trimethylbicyclo[3.1.1]hept-2-
ene
(1S)-6,6-dimethyl-2-            18172-67-3
methylenebicyclo[3.1.1]heptane
1-methyl-4-(1-                  586-62-9
methylethylidene)cyclohexene
1-(3-pyridinyl)ethanone         350-03-8
1-pyrazinylethanone             22047-25-2
1-(2-furyl)-2-propanone         6975-60-6
1-Penten-3-one                  1629-58-9
2,3-pentanedione                600-14-6
2,5-dimethylpyrazine            123-32-0
2-isobutyl-3-methoxypyrazine    24683-00-9
4-methyl-2,3-pentanedione       7493-58-5
5-methylfurfural                620-02-0
Dimethyltrisulfide              3658-80-8
furfuryl acetate                623-17-6
furfurylmethylether             13679-46-4
terpinen-4-ol                   562-74-3
Calcium sorbate                 7492-55-9
Potassium lactate               996-31-6
1-Hydroxyethylidene-1,1-        2809-21-4
diphosphonic acid
L-glutamic acid monopotassium   19473-49-5
salt
3-methyl-2-buten-1-ol           556-82-1
phenylethanal                   122-78-1
4′-Methoxyacetophenone          100-06-1
L-borneol                       464-45-9
2,4-Hexadien-1-ol               111-28-4
D-Fenchone                      4695-62-9
3-Phenylpropyl formate          104-64-3
Cinnamyl formate                104-65-4
D-galacturonate                 685-73-4
D-glucuronate                   1700908
5′ IMP                          131-99-7
1-Methoxy-4-methylbenzene       104-93-8
2-Methylbutanoic acid           116-53-0
2,4,6-Tribromophenol            118-79-6
3-Ethyl pyridine                536-78-7
Zinc acetate                    557-34-6
Methyl pentanoate               624-24-8
Methylthioethane                624-89-5
3-Penten-2-one                  625-33-2
Glycocholic acid                475-31-0
m-Methoxybenzoic acid           586-38-9
alpha-Hydroxypropionic acid     598-82-3
Methyl 2-furoate                611-13-2
2-Furancarboxylic acid, propyl  615-10-1
ester
Benzylacetoacetic acid, ethyl   620-79-1
ester
2,5-Dimethyl pyrrole            625-84-3
4-methyl-1,1′-biphenyl          644-08-6
p-Isopropylacetophenone         645-13-6
4-methyl-thiazole               693-95-8
gamma-Decalactone               706-14-9
2-acetylpyrrole                 1072-83-9
2-acetylpyridine                1122-62-9
tetramethyl-pyrazine            1124-11-4
Methyl 4-phenylbutyrate         2046-17-5
2,3,6-trimethyl-phenol          2416-94-6
2-Methoxypyrazine               3149-28-8
2-Ethylfuran                    3208-16-0
2,3-dimethyl-pyrazine           5910-89-4
Thiophenethiol                  7774-74-5
o-Tolyl isobutyrate             36438-54-7
cis-3-Hexenyl pyruvate          68133-76-6
cis-3-Hexenyl cis-3-hexenoate   61444-38-0
trans-2-Hexenyl isovalerate     68698-59-9
trans-2-Hexenyl formate         53398-78-0
trans-2-Hexenyl valerate        56922-74-8
1-Octen-3-yl butyrate           16491-54-6
Methyl 4-(methylthio)butyrate   53053-51-3
2,4-Octadien-1-ol               18409-20-6
2,4-Nonadien-1-ol               62488-56-6
2,4-Decadien-1-ol               18409-21-7
(e,z)-2,6-Nonadienyl acetate    68555-65-7
3-Hexenal                       4440-65-7
Tetrahydro-2-furanmethanol      637-64-9
acetate
Methyl benzaldehyde             1334-78-7
Dodecylsulfonic acid            1510-16-3
Methylethyl disulfide           4253-89-8
Farnesol                        4602-84-0
Thiobenzoic acid, S-methyl      5925-68-8
ester
Hexyl benzoate                  6789-88-4
2,5-Diethyltetrahydrofuran      41239-48-9
Zinc hydrosulfite               7779-86-4
(2R,3S)-Tartaric Acid           147-73-9
Ethylsulfuric acid              540-82-9
1,2,2-Trimethyl-1,3-            5394-83-2
cyclopentanedicarboxylic acid
2-Methyl-3-buten-2-ol           115-18-4
trans-2-Hexenal                 6728-26-3
4-Hexen-3-one                   2497-21-4
1-Hexen-3-ol                    4798-44-1
2-Methyl-1-butanethiol          1878-18-8
4-Methylcyclohexanone           589-92-4
3-Heptanol                      589-82-2
o-methylanisole                 578-58-5
trans-2-octenal                 2363-89-5
2,3,4-Trimethyl-3-pentanol      3054-92-0
Acetylacetaldehyde dimethyl     5436-21-5
acetal
p-methylacetophenone            122-00-9
o-aminoacetophenone             551-93-9
4-Propylphenol                  645-56-7
2,4-Dimethylanisole             6738-23-4
Benzyl methyl sulfide           766-92-7
Methyl phenylacetate            101-41-7
4-Ethoxybenzaldehyde            10031-82-0
p-tolyl acetate                 140-39-6
2,6-Dimethoxyphenol             91-10-1
Isoborneol                      124-76-5
Methyl 2-methoxybenzoate        606-45-1
Phenylacetaldehyde dimethyl     101-48-4
acetal
3-Phenylpropyl acetate          122-72-5
Ethyl 3-phenylpropionate        2021-28-5
Benzyl butyrate                 103-37-7
Anisyl acetate                  104-21-2
Isobutyl phenylacetate          102-13-6
p-vinylphenol                   2628-17-3
o-tolyl acetate                 533-18-6
2,5-Dihydroxybenzoic acid       490-79-9
o-methoxyphenyl acetate         613-70-7
Lactobionic acid                96-82-2
Magnesium hydrogen phosphate    7782-75-4
trihydrate
Iberverin                       505-79-3
alpha-methylcinnamaldehyde      101-39-3
benzyl phenylacetate            102-16-9
1,3-dimercaptopropane           109-80-8
p-cymen-8-ol                    1197-01-9
phenethyl anthranilate          133-18-6
trihydroxybutyrophenone         1421-63-2
o-methoxycinnamaldehyde         1504-74-1
3-propylidene phthalide         17369-59-4
trans,trans-2,4-decadienal      25152-84-5
piperonyl acetate               326-61-4
2,3-hexanedione                 3848-24-6
isopropyl phenylacetate         4861-85-2
ethyl 3-hydroxybutyrate         5405-41-4
furfural acetone                623-15-4
beta-(2-furyl)acrolein          623-30-3
linalyl anthranilate            7149-26-0
citral diethyl acetal           7492-66-2
allyl anthranilate              7493-63-2
acetyl tributyl citrate         77-90-7
butyl anthranilate              7756-96-9
cyclohexyl anthranilate         7779-16-0
isoamyl cinnamate               7779-65-9
isobutyl anthranilate           7779-77-3
carvyl acetate                  97-42-7
carveol                         99-48-9
3-(Methylthio)propionaldehyde   3268-49-3
Alpha-damascone                 43052-87-5
Dimethyldicarbonate             4525-33-1
Procaine                        59-46-1
5-hydroxy-6-methyl-3,4-         65-23-6
pyridinedimethanol
2-methoxy-Naphthalene           93-04-9
Methyl nicotinate               93-60-7
Ethyl benzoylacetate            94-02-0
Phenethyl benzoate              94-47-3
2-methyl-pentanoic acid         97-61-0
Cyclohexanecarboxylic acid      98-89-5
Methyl b-phenylpropionate       103-25-3
Benzyl 3-methyl butanoate       103-38-8
Naphthalene-2-sulfonic acid     120-18-3
Methyl 4-methoxybenzoate        121-98-2
3-Phenylprop-2-enyl cinnamate   122-69-0
7-methyl-3-methylene-1,6-       123-35-3
Octadiene
Levulinic acid                  123-76-2
2-Mercaptobenzoic acid          147-93-3
m-Dimethoxybenzene              151-10-0
3-butyl-1(3H)-isobenzofuranone  6066-49-5
5-Methylquinoxaline             13708-12-8
2-Ethyl Pyrazine                13925-00-3
trimethyl-pyrazine              14667-55-1
2-ethyl-3-methyl-pyrazine       15707-23-0
2,3-diethyl-pyrazine            15707-24-1
2,3-diethyl-5-methyl-pyrazine   18138-04-0
2-Methylthiopyrazine            21948-70-9
5-Methyl-3H-furan-2-one         591-12-8
cis-3-Hexen-1-ol                928-96-1
3,7-Dimethyl-1,3,6-octatriene   13877-91-3
calcium cyclamate               139-06-0
aconitic acid                   499-12-7
2-Dehydrolinalool               29171-20-8
2-Mercaptopropionic acid        79-42-5
3-Methyl-2-butenal              107-86-8
Allylacetic acid                591-80-0
Allyl cyclohexylacetate         4728-82-9
Allyl cyclohexylpropionate      2705-87-5
Allyl phenoxyacetate            7493-74-5
Allyl phenylacetate             1797-74-6
Allyl alpha-ionone              79-78-7
Butyl butyrolactate             7492-70-8
Cinnamyl isobutyrate            103-59-3
Cinnamyl propionate             103-56-0
Dibenzyl disulfide              150-60-7
Isobornyl acetate               125-12-2
Methyl heptyne carbonate        111-12-6
Triethyl citrate                77-93-0
gamma-Undecalactone             104-67-6
alpha-Amylcinnamyl alcohol      101-85-9
1,3,4,6,7,8 -Hexahydro-         1222-05-5
4,6,6,7,8,8-hexamethyl
cyclopenta[g] [2]benzopyran
2-Ethylbutyl acetate            10031-87-5
Triphosphoric acid,             13845-36-8
pentapotassium salt
L-(+)-Lactic acid               79-33-4
Mannitol                        87-78-5
2-Methoxy-4-methylphenol        93-51-6
1,2,3-Propanetricarboxylic      144-33-2
acid, 2-hydroxy-, disodium
salt
Ethanesulfonic acid, 2-         1562-00-1
hydroxy-, monosodium salt
2-Methoxy-4-propylphenol        2785-87-7
3,7-Dimethyl-3-octanol          78-69-3
2-Pentyl furan                  3777-69-3
Butanoic acid, 3-oxo-, butyl    591-60-6
ester
4-(4-Hydroxy-4-methyl pentyl)-  31906-04-4
3-cyclohexene-1-carboxaldehyde
Methyl 3-oxo-2-                 24851-98-7
pentylcyclopentaneacetate
Naphthalene, 2-(2-              2173-57-1
methylpropoxy)-
Perillol                        536-59-4
2-Acetyl-1-methylpyrrole        932-16-1
4-Allyl-2,6-dimethoxyphenol     6627-88-9
Butyl levulinate                2052-15-5
D-(+)-Camphoric acid            124-83-4
D(+)-10-Camphorsulfonic acid    3144-16-9
L-(−)-Carvone                   6485-40-1
(−)-Carvyl propionate           97-45-0
(−)-Caryophyllene oxide         1139-30-6
Cyclohexylacetic acid           5292-21-7
3-Cyclopentylpropionic acid     140-77-2
(−)-Dihydrocarvyl acetate       20777-49-5
3,3-Dimethylacrylic acid        541-47-9
2,4-Dimethylbenzaldehyde        15764-16-6
1,4-Dithiane-2,5-diol           40018-26-6
Ethanesulfonic acid             594-45-6
Ethyl butyrylacetate            3249-68-1
Ethyl (methylthio) acetate      4455-13-4
Ethyl pyruvate                  617-35-6
Ethyl sorbate                   2396-84-1
5-Formyl-2-furansulfonic acid,  31795-44-5
sodium salt
Furfuryl mercaptan              98-02-2
1,6-Hexanedithiol               1191-43-1
trans-2-Hexenoic acid           13419-69-7
trans-2-Hexen-1-ol              928-95-0
4-(4-Hydroxyphenyl)-2-butanone  5471-51-2
Isopulegol                      89-79-2
Isopulegyl acetate              89-49-6
2-Ketobutyric acid              600-18-0
(−)-Limonene                    5989-54-8
4-Methoxyphenylacetone          122-84-9
Methyl cyclohexanecarboxylate   4630-82-4
3-Methylcyclohexanone           591-24-2
3-Methyl-2-cyclohexen-1-one     1193-18-6
3-Methyl-1,2-cyclopentanedione  765-70-8
3-Methyl-2-cyclopenten-1-one    2758-18-1
N-Methyl-D-glucamine            6284-40-8
Methyl 3-                       13532-18-8
(methylthio)propionate
4-Methyl-5-thiazoleethanol      137-00-8
5-Methyl-2-                     13679-70-4
thiophenecarboxaldehyde
DL-3-Methylvaleric acid         105-43-1
(−)-Myrtenal                    564-94-3
Nopol                           128-50-7
gamma-Octanoic lactone          104-50-7
3-Octanol                       589-98-0
E-2-Octenoic acid               1871-67-6
Pamoic acid                     130-85-8
4-Phenyl-2-butyl acetate        10415-88-0
1-Phenyl-1,2-propanedione       579-07-7
2-Phenylpropyl butyrate         80866-83-7
2-Phenylpropyl isobutyrate      65813-53-8
cis-2-Hexen-1-ol                928-94-9
Bis(methylthio)methane          1618-26-4
Magnesium carbonate hydroxide,  39409-82-0
Light
N-Acetyl-L-methionine           65-82-7
4-Methyl-5-vinylthiazole        1759-28-0
2-Methyl-1-phenyl-2-propanol    100-86-7
3-Phenylpropionaldehyde         104-53-0
N-Benzyl-2-phenylethylamine     3647-71-0
1-Phenylethyl propionate        120-45-6
3-Phenylpropyl isobutyrate      103-58-2
Allyl hexanoate                 123-68-2
alpha, 4-Dimethylbenzylalcohol  536-50-5
(−)-Menthyl lactate             59259-38-0
2,6-Dimethylthiophenol          118-72-9
2,4,5-Trimethylthiazole         13623-11-5
Ethyl 3-(methylthio)propionate  13327-56-5
Phenylethyl isovalerate         140-26-1
2-Propylpyrazine                18138-03-9
2-Methyltetrahydrofuran-3-one   3188-00-9
Ethyl 2-                        23747-43-5
(methyldithio)propionate
3,4-Dimethyl-1,2-               13494-06-9
cyclopentanedione
Difurfurylsulfide               13678-67-6
Difurfuryldisulfide             4437-20-1
3-(Methylthio)propanol          505-10-2
Methyl phenyl disulfide         14173-25-2
2-(Methyldithio)-               67952-60-7
isobutyraldehyde
Methyl 2-thiofuroate            13679-61-3
2-Isobutylthiazole              18640-74-9
4-Methyl-5-thiazolylethyl       656-53-1
acetate
2-Acetylthiazole                24295-03-2
2-Ethyl-3,5(6)-                 27043-05-6
dimethylpyrazine
5-Methyl-6,7-dihydro-5H-        23747-48-0
cyclopenta(b)pyrazine
Cinnamyl acetate                103-54-8
2,5-Dihydroxy-2,5-dimethyl-     55704-78-4
1,4-dithiane
5,6,7,8-Tetrahydroquinoxaline   34413-35-9
2-Methyl-3-furanethiol          28588-74-1
Styrallyl acetate               93-92-5
2-Methylhexanoic acid           4536-23-6
2-Methylheptanoic acid          1188-02-9
2,2,6-Trimethylcyclohexanone    2408-37-9
L-Tyrosine ethyl ester          4089-07-0
hydrochloride
Ethyl 4-methoxybenzoate         94-30-4
4-Ethylbenzaldehyde             4748-78-1
N-Ethyl-p-menthane-3-           39711-79-0
carboxamide
1-(2-Furyl)-1,3-butanedione     25790-35-6
Menthofuran                     494-90-6
Methylsulfuric acid sodium      512-42-5
salt
Sucrose diacetate               126-13-6
hexaisobutyrate
N,2,3-Trimethyl-2-              51115-67-4
isopropylbutamide
Tripropionin                    139-45-7
(+/−)-Citronellic acid          502-47-6
5-Acetyl-2,4-dimethylthiazole   38205-60-6
Neryl acetate                   141-12-8
Benzyl propionate               122-63-4
1R-(−)-Camphorsulfonic acid     35963-20-3
3,4-Hexanedione                 4437-51-8
cis-3-Hexenoic acid             4219-24-3
cis-4-Heptenal                  6728-31-0
(E,Z)-2,6-nonadienal            557-48-2
trans-2,trans-6-Nonadienal      17587-33-6
4-Methyl-2-pentenal             5362-56-1
cis-6-Nonenal                   2277-19-2
Methyl propyl disulfide         2179-60-4
8-p-Menthen-1-ol                138-87-4
p-Menthan-2-one                 499-70-7
Bisabolene                      495-62-5
Ethyl cyclohexanecarboxylate    3289-28-9
Phenylpyruvate                  156-06-9
Hydroxypyruvate                 1113-60-6
4-Methyl-2-oxopentanoate        816-66-0
(+)-Neomenthol                  2216-52-6
trans-Citral                    141-27-5
Piperitenone                    491-09-8
Sabinene hydrate                546-79-2
Perillyl aldehyde               2111-75-3
2-Hydroxyethanesulfonate        107-36-8
Acetyl isovaleryl               13706-86-0
Acetyl valeryl                  96-04-8
Butylidene phthalide            551-08-6
Carvacryl ethyl ether           4732-13-2
Ethyl vanillin propylene        68527-76-4
glycol acetal
Hexyl hexanoate                 6378-65-0
2-Methyl-5-(methylthio)-furan   13678-59-6
2-Methyl-4-pentenoic acid       1575-74-2
2-Methyl-4-propyl-1,3-          67715-80-4
oxathiane
3-Methylthio-1-hexanol          51755-66-9
cis-6-Nonenol                   35854-86-5
Rose oxide                      16409-43-1
L-Linalool                      126-91-0
5,6-Dimethyl-8-                 4674-50-4
isopropenylbicyclo[4.4.0]dec-
1-en-3-one
2-Ethyl-3,5-dimethylpyrazine    13925-07-0
2-Isopropylpyrazine             29460-90-0
2-Isobutyl-3-methyl-pyrazine    13925-06-9
2-Methoxy-3-sec-butyl-pyrazine  24168-70-5
2-Methylthio-3(6)-methyl-       67952-65-2
pyrazine
Benzylcarbinyl propionate       122-70-3
Bornyl acetate                  76-49-3
furaneol                        3658-77-3
Methoxycinnamaldehyde           1963-36-6
Methylphenol, hydrogen sulfate  68127-34-4
Lactitol monohydrate            81025-04-9
2H-Pyrrole, 3,4-dihydro-        5724-81-2
2-Butenal, 2-methyl-, (E)-      497-03-0
2-Pentenal                      764-39-6
Ethanethioic acid, S-methyl     1534-08-3
ester
2-Hexenal                       505-57-7
2-Methyl-2-pentenal             623-36-9
Cyclopentanethiol               1679-07-8
Butane, 2-ethoxy-               2679-87-0
S-Ethyl thioacetate             625-60-5
ethyl methyl carbonate          623-53-0
3(2H)-Furanone, 2,5-dimethyl-   14400-67-0
Allyl propionate                2408-20-0
methyl 2-methylbutanoate        868-57-5
2-Butanone, 1-(methylthio)-     13678-58-5
Ethanethioic acid, S-propyl     2307-10-0
ester
1,2-Butanedithiol               16128-68-0
6-Methyl-3,5-heptadiene-2-one   1604-28-0
2-Octen-4-one                   4643-27-0
2,5-dimethyl-3-furanthiol       55764-23-3
2-Heptenoic acid                18999-28-5
Butanoic acid, 2-propenyl       2051-78-7
ester
6-Methyl-5-hepten-2-ol          1569-60-4
trans-2-Octen-4-ol              20125-81-9
cis-3-Octen-1-ol                20125-84-2
1-Butanol, 2-methyl-, acetate   624-41-9
4-methyl-alpha-methylstyrene    1195-32-0
trans-3-Phenyl-2-propen-1-ol    4407-36-7
Benzeneacetaldehyde, alpha-     93-53-8
methyl-
Benzene, (2-methoxyethyl)-      3558-60-9
Cyclohexene, 1-methyl-4-(1-     7705-14-8
methylethenyl)-, (+−)-
Phenol, 2-(methylthio)-         1073-29-6
2-Hexen-1-yl acetate            2497-18-9
3-Hexen-1-ol, acetate, (Z)-     3681-71-8
5-Hydroxy-4-octanone            496-77-5
butyl 2-methylpropanoate        97-87-0
Benzofuran-2-carboxaldehyde     4265-16-1
DL-Lysine                       70-54-2
1-Hexanethiol, 2-ethyl-         7341-17-5
2′,4′-Dimethylacetophenone      89-74-7
2-Pentylpyridine                2294-76-0
1-Methoxy-4-propyl benzene      104-45-0
1-Hydroxy-2-methoxy-4-ethyl     2785-89-9
benzene
Nonalactone                     6008-27-1
Cyclohexyl propionate           6222-35-1
Allyl 2-ethylbutyrate           7493-69-8
Butanoic acid, 3-oxo-, 2-       7779-75-1
methylpropyl ester
n-Butyl pentanoate              591-68-4
3,7-Dimethyl-1-octanol          106-21-8
3-Buten-2-one, 3-methyl-4-      1901-26-4
phenyl-
2-Propenoic acid, 3-phenyl-,    1754-62-7
methyl ester, (E)-
Benzene, 4-ethenyl-1,2-         6380-23-0
dimethoxy-
Benzenepropanol, alpha,alpha-   103-05-9
dimethyl-
Benzene, (butoxymethyl)-        588-67-0
Dimethyl anthranilate           85-91-6
2-Hexanoylfuran                 14360-50-0
Cyclohexyl butyrate             1551-44-6
Naphthalene, 2-ethoxy-          93-18-5
Acetoacetic acid isoamyl ester  2308-18-1
Propanoic acid, 2-methyl-, 4-   103-93-5
methylphenyl ester
4-(4-Methoxyphenyl)-2-butanone  104-20-1
Isobutyl benzoate               120-50-3
Benzene, 1,2-dimethoxy-4-(1-    93-16-3
propenyl)-
beta-                           10415-87-9
Phenylethylmethylethylcarbinol
1,1-Dimethoxy-2-phenylpropane   90-87-9
Geranyl formate                 105-86-2
Bornyl formate                  7492-41-3
6-Octen-1-ol, 3,7-dimethyl-,    105-85-1
formate
Benzeneacetic acid, butyl       122-43-0
ester
3,5,9-Undecatrien-2-one, 6,10-  141-10-6
dimethyl-
Anisyl propionate               7549-33-9
Butanoic acid, 3-phenyl-2-      103-61-7
propenyl ester
2-Propenoic acid, 3-phenyl-,    122-67-8
2-methylpropyl ester
Eugenyl acetate                 93-28-7
3-Methylbutyl phenylacetate     102-19-2
Benzoic acid, 2-(methylamino)-, 65505-24-0
2-methylpropyl ester
Phenoxy ethyl isobutyrate       103-60-6
Anisyl butyrate                 6963-56-0
2,6-Octadien-1-ol, 3,7-         105-91-9
dimethyl-, propanoate, (Z)-
Isobornyl propionate            2756-56-1
1,3,5-Trithiane, 2,2,4,4,6,6-   828-26-2
hexamethyl-
Geranyl N-butyrate              106-29-6
Geranyl isobutyrate             2345-26-8
Thiophene, 2,2′-dithiobis-      6911-51-9
2-Propenoic acid, 3-phenyl-,    7779-17-1
cyclohexyl ester
Benzeneacetic acid, 3-phenyl-   7492-65-1
2-propenyl ester
Anisyl phenylacetate            102-17-0
2-Propenoic acid, 3-phenyl-,    122-68-9
3-phenylpropyl ester
Geranyl phenylacetate           102-22-7
hexyl 2-methylbutyrate          10032-15-2
4-heptanolide                   105-21-5
Neral                           106-26-3
(E)-2-octenol                   18409-17-1
Ethyl 3-hydroxyhexanoate        2305-25-1
isopropyl hexanoate             2311-46-8
hexyl butanoate                 2639-63-6
bis(2-methyl-3-furyl)disulfide  28588-75-2
3-hydroxy-4,5-dimethyl-2(5H)-   28664-35-9
furanone
2-acetyl-2-thiazoline           29926-41-8
(E,E)-2,4-octadienal            30361-28-5
geranyl acetone                 3796-70-1
1-octen-3-one                   4312-99-6
3-mercapto-2-pentanone          67633-97-0
(Z)-3-hexenal                   6789-80-6
4-hexanolide                    695-06-7
5-octanolide                    698-76-0
delta-decalactone               705-86-2
4-vinylguaiacol                 7786-61-0
Amyl salicylate                 2050-08-0
Cyclohexyl formate              4351-54-6
Dimethylbenzylcarbinyl acetate  151-05-3
Geranyl propionate              105-90-8
Terpinyl acetate                80-26-2
isopropyl 3-methylbutanoate     32665-23-9
isopropyl 2-methylbutanoate     66576-71-4
3-Hexenyl 3-methylbutanoate     10032-11-8
Isoamyl 2-methylbutyrate        27625-35-0
3-Octyl acetate                 4864-61-3
Benzyl isobutyrate              103-28-6
Cis-3-hexenyl butyrate          16491-36-4
Cis-3-hexenyl lactate           61931-81-5
Citronellyl butyrate            141-16-2
Citronellyl propionate          141-14-0
Isoamyl hexanoate               2198-61-0
1,3,5-Undecatriene              16356-11-9
1-Benzyloxy-2-methoxy-4-        120-11-6
propenyl benzene
1-Octen-3-yl acetate            198242
2-Acetyl-3-ethyl pyrazine       32974-92-8
2-Isopropyl-4-methyl thiazole   15679-13-7
2-Methyl-2-pentenoic acid       3142-72-1
2-sec-butyl thiazole            18277-27-5
4,5-Dimethyl thiazole           3581-91-7
4-(2,6,6-Trimethyl-2-           31499-72-6
cyclohexen-1-yl)butan-2-one
4-(2,6,6-Trimethyl cyclohexa-   23696-85-7
1,3-dienyl)but-2-en-4-one
Acetaldehyde phenethyl propyl   7493-57-4
acetal
Acetaldehyde ethyl cis-3-       28069-74-1
hexenyl acetal
Acetone propylene glycol        1193-11-9
acetal
Acetyl isoeugenol               93-29-8
2-Acetyl-5-methyl furan         1193-79-9
Allyl cyclohexylbutyrate        7493-65-4
Alpha,alpha-dimethylphenethyl   10094-34-5
butyrate
Alpha,alpha-dimethyl phenethyl  10058-43-2
formate
Alpha,beta-santalol             11031-45-1
Alpha-amyl cinnamaldehyde       91-87-2
dimethyl acetal
Alpha-fenchyl acetate           13851-11-1
Alpha-furfuryl pentanoate       36701-01-6
Alpha-ionol                     25312-34-9
6-Methyl-alpha-ionone           79-69-6
Alpha-methyl-p-                 103-95-7
isopropylphenylpropanaldehyde
Alpha-n-amyl-beta-phenylacryl   7493-78-9
acetate
Alpha-piperitone                6091-50-5
Alpha-n-amyl-beta-phenyl acryl  7493-80-3
isovalerate
6-Amyl-alpha-pyrone             27593-23-3
Anisyl formate                  122-91-8
Benzylcarbinyl 2-methyl         24817-51-4
butyrate
Benzylcarbinyl 3-phenyl         103-53-7
propenoate
Benzylcarbinyl alpha-toluate    102-20-5
Benzylcarbinyl butyrate         103-52-6
Benzylcarbinyl caproate         6290-37-5
Benzylcarbinyl formate          104-62-1
Benzylcarbinyl isobutyrate      103-48-0
Benzylcarbinyl salicylate       87-22-9
Benzylcarbinyl tiglate          55719-85-2
Benzyl dipropyl ketone          7492-37-7
Benzyl tiglate                  37526-88-8
Beta-homocyclocitral            472-66-2
Beta-ionol                      22029-76-1
3-Phenylpropyl propanoate       122-74-7
Bois de rose oxide              7392-19-0
Butyl 2-methyl butyrate         15706-73-7
Butyl cinnamate                 538-65-8
ortho-sec-Butyl cyclohexanone   14765-30-1
isobutyl cis-2-methyl-2-        7779-81-9
butenoate
5-n-Butyl-delta-valerolactone   3301-94-8
Campholenic aldehyde            4501-58-0
Cedran-8-yl acetate             77-54-3
Cinnamyl isovalerate            140-27-2
Cis-3-hexenyl benzoate          25152-85-6
Cis-3-hexenyl caproate          31501-11-8
Cis-3-hexenyl formate           33467-73-1
Cis-3-hexenyl isobutyrate       41519-23-7
Cis-3-hexenyl phenylacetate     42436-07-7
Cis-3-hexenyl propionate        33467-74-2
Cis-3-hexenyl tiglate           67883-79-8
Cis-3-hexenyl valerate          35852-46-1
cis-4-Hepten-1-ol               6191-71-5
Cis-5-octen-1-ol                64275-73-6
Citral dimethyl acetal          7549-37-3
Citronellyl isobutyrate         97-89-2
Citronellyl isovalerate         68922-10-1
Citronellyl valerate            7540-53-6
Citroxide                       7416-35-5
Cocal                           21834-92-4
p-Cresyl alpha-toluate          101-94-0
p-Cresyl isovalerate            55066-56-3
Dehydro-beta-cyclocitral        116-26-7
8,8-Diethoxy-2,6-dimethyl-2-    7779-94-4
octanol
5,7-Dihydro-2-methyl            36267-71-7
thieno(3,4-d)pyrimidine
2,5-Dihydro-4,5-dimethyl-2-(2-  65894-83-9
methyl propyl)thiazole
Dihydrojasmone                  1128-08-1
Dihydroxyacetophenone           28631-86-9
1,1-Dimethoxy-3,7-dimethyl-7-   141-92-4
octanol
3,7-Dimethyl-1,6-octadien-3-yl  126-64-7
benzoate
3,7-Dimethyl-1,6-octadien-3-yl  78-36-4
butyrate
3,7-Dimethyl-1,6-octadien-3-yl  78-35-3
isobutyrate
3,7-Dimethyl-1,6-octadien-3-yl  144-39-8
propanoate
cis-3,7-Dimethyl-2,6-octadien-  2345-24-6
1-yl 2-methyl propanoate
2,4-Dimethyl-3-cyclohexene-1-   68039-49-6
carboxaldehyde
2,6-Dimethyl-5-hepten-1-al      106-72-9
trans,cis-2,6-Dodecadien-1-al   21662-13-5
Eglantal                        26643-91-4
Ethyl E-2-hexenoate             27829-72-7
Ethyl tiglate                   5837-78-5
Ethyl trans-4-decenoate         76649-16-6
5-Ethyl-4-hydroxy-2-methyl-     27538-09-6
3[2H]furanone
2-Ethyl-4-methyl thiazole       15679-12-6
2,6,10-Trimethyl-2,6,10-        762-29-8
pentadecatrien-14-one
Guaiacyl phenyl acetate         4112-89-4
3-Hepten-2-one                  1119-44-4
trans-2-Hexen-1-ol              2305-21-7
Trans-2-hexenyl butyrate        53398-83-7
Hexyl phenylacetate             5421-17-0
Hexyl propionate                2445-76-3
Hydroxycitronellol              107-74-4
Isobutyl 2-butenoate            589-66-2
Isobutyl salicylate             87-19-4
Isodihydro lavandulal           35158-25-9
Isoeugenyl phenyl acetate       120-24-1
Isopropyl alpha-                1733-25-1
methylcrotonate
p-Menth-1-en-8-yl propionate    80-27-3
Menthalactone                   13341-72-5
3-Methoxy-p-cymene              1076-56-8
Methyl 4-methyl pentanoate      2412-80-8
alpha-Methyl benzyl formate     7775-38-4
2-Methylbutyl 2-                2445-78-5
methylbutanoate
Methyl e-2-octenoate            2396-85-2
p-Methyl hydratropaldehyde      99-72-9
3-(5-Methyl-2-furyl)butanal     31704-80-0
Nerol oxide                     1786-08-9
trans,cis-2,6-Nonadien-1-ol     7786-44-9
trans-2-Octen-1-yl acetate      3913-80-2
3-Octen-2-one                   1669-44-9
2-Phenyl-2-butenal              4411-89-6
2-Propionylthiazole             43039-98-1
1-Hydroxy-2-butanone            5077-67-8
2-Butanone, 3-hydroxy-, (+−)-   52217-02-4
Thiazole, 2,5-dimethyl-         4175-66-0
Butanethioic acid, S-methyl     2432-51-1
ester
2,4-Hexadienoic acid, methyl    689-89-4
ester, (E,E)-
Benzeneacetaldehyde, 4-methyl-  104-09-6
Bicyclo[4.1.0]hept-3-ene,       498-15-7
3,7,7-trimethyl-, (1S)-
Ethyl 3-hexenoate               2396-83-0
1H-Pyrrole, 1-(2-               1438-94-4
furanylmethyl)-
6-Octenal, 3,7-dimethyl-, (R)-  2385-77-5
Ethanethioic acid, S-(2-        13678-68-7
furanylmethyl) ester
6-Octen-1-ol, 3,7-dimethyl-,    1117-61-9
(R)-
6-Octen-1-ol, 3,7-dimethyl-,    7540-51-4
(S)-
DL-Tetrohydrofurfuryl           637-65-0
propionate
Benzenepentanol                 10521-91-2
Cyclohexaneethanol, acetate     21722-83-8
Benzyl isobutyl ketone          5349-62-2
Butanoic acid, 3-oxo-,          5396-89-4
phenylmethyl ester
1,2-Ethanediamine, N,N′-        140-28-3
bis(phenylmethyl)-
2-Ethyl-3-hydroxy-4-pyrone      1110651
Dicyclohexyl disulfide          2550-40-5
Tetrahydrofurfuryl butyrate     2217-33-6
Thujone                         546-80-5
Benzyl alcohol, alpha-methyl-,  3460-44-4
butyrate
Citronellyl tiglate             24717-85-9
Lactitol                        585-86-4
Nonivamide                      2444-46-4
2-Acetoxy-3-butanone            4906-24-5
3-Acetyl-2,5-dimethylthiophene  230378
3-Acetyl-2-5dimethylfuran       10599-70-9
4-Acetyl-6-t-butyl-1,1-         13171-00-1
dimethylindan
Allyl 2-furoate                 4208-49-5
Allyl sorbate                   7493-75-6
Allyl thiopropionate            41820-22-8
Allyl tiglate                   7493-71-2
Amylcyclohexyl acetate          67874-72-0
Benzaldehyde glyceryl acetal    1319-88-6
Benzaldehyde propylene glycol   2568-25-4
acetal
Bornyl isovalerate              76-50-6
1,3-Butanedithiol               24330-52-7
2,3-Butanedithiol               4532-64-3
Butyl cinnamic aldehyde         7492-44-6
Cinnamyl benzoate               5320-75-2
Citral ethylene glycol acetal   66408-78-4
Citronellyloxyacetaldehyde      7492-67-3
Citronellyl phenylacetate       139-70-8
Cyclohexyl isovalerate          7774-44-9
Decalactone                     5579-78-2
2,5-Dimethyl-4-methoxy-3(2H)-   4077-47-8
furanone
6,10-Dimethyl-9-undecen-2-one   4433-36-7
2-Ethoxythiazole                15679-19-3
Ethyl 2-mercaptopropionate      19788-49-9
Ethyl 2-methyl-4-pentenoate     53399-81-8
Ethyl 3-(2-furyl)propanoate     94278-27-0
Ethyl cyclohexanepropionate     10094-36-7
Ethyl (p-tolyloxy)acetate       67028-40-4
3-Ethyl-2-hydroxy-2-            21835-01-8
cyclopenten-1-one
Ethylene brassylate             105-95-3
2-Ethylfenchol                  18368-91-7
Furfuryl 3-methylbutanoate      13678-60-9
Furfuryl butyrate               623-21-2
Furfuryl isopropyl sulfide      1883-78-9
Furfuryl methyl sulfide         1438-91-1
Furfuryl propionate             623-19-8
Furfuryl thiopropionate         59020-85-8
Geranyl acetoacetate            10032-00-5
Geranyl benzoate                94-48-4
Geranyl isovalerate             109-20-6
delta-Hexalactone               823-22-3
trans-3-Hexenal                 69112-21-6
cis-3-Hexenyl anthranilate      65405-76-7
trans-2-Hexenyl propionate      53398-80-4
5-(cis-3-Hexenyl) dihydro-5-    70851-61-5
methyl-2(3H)furanone
Hexyl 2-formate                 39251-86-0
Hexyl crotonate                 19089-92-0
Hexyl formate                   629-33-4
Isoamyl 3-(2-furyl)propionate   7779-67-1
Isoamyl pyruvate                7779-72-8
Isobutyl furylpropionate        105-01-1
Isohexenyl cyclohexenyl         37677-14-8
carboxaldehyde
p-Isopropyl phenylacetaldehyde  4395-92-0
Linalyl cinnamate               78-37-5
Linalyl formate                 115-99-1
Linalyl isovalerate             1118-27-0
Linalyl phenylacetate           7143-69-3
Maltol isobutyrate              65416-14-0
Methyl 2-methylpentanoate       2177-77-7
Methyl 3-hydroxyhexanoate       21188-58-9
Methyl 3-nonenoate              13481-87-3
Methyl furfuryl disulfide       57500-00-2
Methyl p-tert-                  3549-23-3
butylphenylacetate
3-Methyl-1,2-cyclohexanedione   3008-43-3
alpha-Methylanisalacetone       104-27-8
2-Methylbutyl isovalerate       2445-77-4
4-Methylnonanoic acid           45019-28-1
4-Methyloctanoic acid           54947-74-9
2-Methyltetrahydrothiophen-3-   13679-85-1
one
3-(Methylthio)butanal           16630-52-7
4-(Methylthio)butanol           20582-85-8
4-Methylthio-2-butanone         34047-39-7
4-Methylthio-4-methyl-2-        23550-40-5
pentanone
Neryl butyrate                  999-40-6
Neryl formate                   2142-94-1
Neryl isovalerate               3915-83-1
Octahydrocoumarin               4430-31-3
Phenethyl 2-furoate             7149-32-8
1-Phenyl-2-pentanol             705-73-7
Phenylacetaldehyde              68345-22-2
diisobutylacetal
Phenylacetaldehyde glyceryl     29895-73-6
acetal
2-(3-Phenylpropyl)pyridine      2110-18-1
Propyl phenylacetate            4606-15-9
Pyrazineethanethiol             35250-53-4
Ethyl 2-methyl pentanoate       39255-32-8
Methyl 2,4-decadienoate         4493-42-9
alpha-Isomethyl ionone          127-51-5
5-Methyl hexanoic acid          628-46-6
Ethyl 3-methyl pentanoate       5870-68-8
Ethyl 2-methyl-3,4-             60523-21-9
pentadienoate
3-Nonen-2-one                   14309-57-0
5-Methyl-3-hexen-2-one          5166-53-0
Maltol propionate               68555-63-5
2-Methyl-3-(2-furyl) acrolein   874-66-8
Ethyl 3(2-furyl)propanoate      10031-90-0
2-Phenyl-3-(2-furyl)-propenal   57568-60-2
4-Methyl-2-pentyl-1,3-          1599-49-1
dioxolane
2-Ethyl-4,5-dimethyl oxazole    53833-30-0
Isobornyl isovalerate           7779-73-9
Theophylline-7-acetic acid      652-37-9
Ethyl trans-2-octenoate         7367-82-0
DL-Arginine                     7200-25-1
Allyl Crotonate                 20474-93-5
2-Methoxystyrene                612-15-7
Magnesium Fumarate              7704-71-4
2-Propionylpyrrole              1073-26-3
2-methyl-1,3-dithiolane         5616-51-3
2-ethyl-5-methyl pyrazine       13360-64-0
2-methyl-3-(dimercaptomethyl)-  65505-17-1
furan
Magnesium gluconate             3632-91-5
Manganese gluconate             6485-39-8
Erythritol                      149-32-6
D-Arabinose                     28697-53-2
D-Galactose                     59-23-4
D-(+)-Mannose                   3458-28-4
Sorbitol                        50-70-4
Aspartame                       22839-47-0
Cyclamic Acid                   100-88-9
Dulcin                          150-69-6
Glucose-1-phosphate             29732-59-0
Dipotassium Salt
L-(+)-Arabinose                 87-72-9
Fructose-6-Phosphate            643-13-0
D-Maltose Monohydrate           6363-53-7
Ribose                          24259-59-4
Fructose 1,6-Diphosphate        26177-85-5
Disodium Salt
Saccharin sodium, dihydrate     6155-57-3
1,2-Benzisothiazol-3(2H)-one    6485-34-3
1,1-dioxide, calcium salt
1,2-Benzisothiazolin-3-one      10332-51-1
1,1-dioxide, potassium salt
zeranol                         26538-44-3
beta-D-fructopyranose           7660-25-5
D-fructose 1,6-bisphosphate     488-69-7
Ribose 5-phosphate              4300-28-1
Arabinose                       147-81-9
Saccharin, sodium salt hydrate  82385-42-0
Maltitol                        585-88-6
D-Fructose 1-phosphate          15978-08-2
D-Sorbitol 6-phosphate          108392-12-
alpha-D-Xylose                  31178-70-8
Inositol 1-phosphate            573-35-3

[0227]

TABLE 3
Name                           CAS #
Sodium Metabisulfite           7681-57-4
sodium hydrogen phosphate      7558-79-4
Sodium Phosphate Monobasic     7558-80-7
Sodium thiosulfate             7772-98-71
Orthoboric acid                10043-35-3
Diethanolamine                 111-42-2
Benzaldehyde                   100-52-7
Sorbic acid                    110-44-1
L-(+)-Tartaric Acid            87-69-4
D-mannitol                     69-65-8
Butyl paraben                  94-26-8
Thymol                         89-83-8
Methyl salicylate              119-36-8
Citric acid                    77-92-9
Creatinine                     60-27-5
Vitamin C                      50-81-7
Benzoic Acid                   65-85-0
Methyl 4-hydroxybenzoate       99-76-3
m-Cresol                       108-39-4
p-Cresol                       106-44-5
Aspirin                        50-78-2
Phenol                         108-95-2
Sucrose                        57-50-1
Potassium citrate, monohydrate 1534146
Sodium acetate                 127-09-3
Lactic acid                    50-21-5
Propionic acid, sodium salt    65-85
Benzyl alcohol                 100-51-6
Phenethyl alcohol              60-12-8
Cholesterol                    57-88-5
D-Glucose                      50-99-7
Sorbitol                       50-70-4
Aspartame                      22839-47-0
Saccharin                      81-07-2
2,6-Di-tert-Butyl-p-Cresol     128-37-0
4-Chloro-3-methylphenol        59-50-7
glycerin                       56-81-5
Propyl paraben                 94-13-3
fumaric acid                   110-17-8
dabco                          280-57-9
p-Phenylenediamine             106-50-3
Anethole                       4180-23-8
propyl gallate                 121-79-9
L-monosodium glutamate         142-47-2
Butylated hydroxyanisole       25013-16-5
Cyclohexanol, 5-methyl-2-(1-   89-78-1
methylethyl)-,
(1alpha, 2beta, 5alpha)-
alpha-Thioglycerol             96-27-5
Sodium dehydroacetate          4418-26-2
Ethyl 4-hydroxybenzoate        120-47-8
Ethyl Vanillin                 121-32-4
Triacetin                      102-76-1
Potassium sorbate              590-00-1
Triethyl citrate               77-93-0
(S)-(+)-Arginine               74-79-3
Glycine                        56-40-6
(S)-(−)-Histidine              71-00-1
(S)-(+)-Lysine                 56-87-1
Quinone                        106-51-4
Naphthalene, 2-ethoxy-         93-18-5
Methanesulfonic Acid           75-75-2
DL-Tartaric Acid               133-37-9
Cyclamic acid                  100-88-9
(S)-(−)-Phenylalanine          63-91-2
(S)-(−)-Tyrosine               60-18-4
Carvone                        99-49-0
Ethyl butyrate                 105-54-4
6-Methyl-5-hepten-2-one        110-93-0
Ethyl acetoacetate             141-97-9
Methyl benzoate                93-58-3
Phenylacetic Acid              103-82-2
Adipic acid                    124-04-9
Ethyl benzoate                 93-89-0
Benzyl benzoate                120-51-4
Pyruvic acid                   127-17-3
Succinic acid                  110-15-6
Indole                         120-72-9
Methyl anthranilate            134-20-3
Diethyl malonate               105-53-3
Niacin                         59-67-6
Meso-inositol                  87-89-8
4-Aminobenzoic acid            150-13-0
Anisole                        100-66-3
Urea                           57-13-6
Pyrrolidine                    123-75-1
Cyclopentanone                 120-92-3
Acetic anhydride               108-24-7
Benzophenone                   119-61-9
D-(−)-Fructose                 57-48-7
D-(+)-Xylose                   58-86-6
o-Methoxybenzoic Acid          579-75-9
linalool                       78-70-6
ethyl isovalerate              108-64-5
1,1′-Azobisformamide           123-77-3
6-Methylcoumarin               92-48-8
acetoin                        513-86-0
alpha-Phellandrene             99-83-2
Cymene                         99-87-6
Dimethyl Succinate             106-65-0
p-Anisaldehyde                 123-11-5
Phenyl ether                   101-84-8
Tetrahydro-2-furanmethanol     97-99-4
Valeric Acid                   109-52-4
3,4-xylenol                    95-65-8
1,1-diethoxyethane             105-57-7
ethyl butyraldehyde            97-96-1
Ethyl crotonate                623-70-1
ethyl isobutyrate              97-62-1
methyl isovalerate             556-24-1
methyl propionate              554-12-1
methyl valeraldehyde           123-15-9
4-(2,6,6-Trimethyl-2-          127-41-3
cyclohexen-1-yl)-3-buten-2-one
4-(2,6,6-trimethyl-1-          14901-07-6
cyclohexen-1-yl)-3-buten-2-one
Maleic acid                    110-16-7
3-Methylbutanoic acid          503-74-2
L-Glutamic Acid                56-86-0
D-limonene                     5989-27-5
1-Phenyl-1-propanol            93-54-9
2′-Hydroxyacetophenone         118-93-4
2,4-Dihydroxybenzoic Acid      89-86-1
2-Phenyl-1-propanol            1123-85-9
3-Phenylpropionic Acid         501-52-0
4-Ethoxyphenol                 622-62-8
Alpha-Terpineol                98-55-5
Benzaldehyde Dimethylacetal    1125-88-8
Benzyl Ether                   103-50-4
Benzyl Formate                 104-57-4
Benzyl Salicylate              118-58-1
Cinnamyl Alcohol               104-54-1
D-(+)-Glucono-1,5-lactone      4253-68-3
D-Isoascorbic Acid             89-65-6
2,3-Naphthalenediol            92-44-4
Diethyl Succinate              123-25-1
Ethyl 2-Aminobenzoate          87-25-2
Ethyl Cinnamate                103-36-6
Ethyl Phenylacetate            101-97-3
Ethyl Salicylate               118-61-6
gamma-Valerolactone            108-29-2
Hydroquinone Dimethyl Ether    150-78-7
Isocaproic Acid                646-07-1
Isoeugenol                     97-54-1
Isopropyl Benzoate             939-48-0
L-(+)-Isoleucine               73-32-5
L-Malic acid                   97-67-6
L-2-Aminopropionic Acid        56-41-7
L-Carnitine                    541-15-1
L-Glutamine                    56-85-9
L-Hydroxyproline               51-35-4
L-Proline                      147-85-3
L-Serine                       56-45-1
L-Threonine                    72-19-5
L-Valine                       72-18-4
Phenoxyacetic Acid             122-59-8
Veratrole                      91-16-7
2-Ethylbutyric acid            88-09-5
2-Methylpyrazine               109-08-0
o-methoxybenzaldehyde          135-02-4
L-Leucine                      61-90-5
L-Asparagine                   70-47-3
propiophenone                  93-55-0
5-isopropyl-2-methyl-phenol    499-75-2
Xylitol                        87-99-0
ethyl 4-oxopentanoate          539-88-8
methyl cinnamate               103-26-4
cumic alcohol                  536-60-7
methyl 2-naphthyl ketone       93-08-3
1-methyl-4-(1-methylethyl)-    99-85-4
1,4-Cyclohexadiene
en-ethylene diamine
Caffeine                       58-08-2
5-methylfurfural               620-02-0
furfuryl acetate               623-17-6
terpinen-4-ol                  10482-56-1
phenylethanal                  122-78-1
4′-Methoxyacetophenone         100-06-1
D-Fenchone                     4695-62-9
1-Methoxy-4-methylbenzene      104-93-8
o-methylanisole                578-58-5
Acetylacetaldehyde dimethyl    5436-21-5
acetal
p-methylacetophenone           122-00-9
Methyl phenylacetate           101-41-7
4-Ethoxybenzaldehyde           10031-82-0
p-tolyl acetate                140-39-6
2,6-Dimethoxyphenol            91-10-1
Methyl 2-methoxybenzoate       606-45-1
alpha-methylcinnamaldehyde     101-39-3
2-methoxycinnamaldehyde        60125-24-8
Potassium bicarbonate          298-14-6
piperonyl acetate              326-61-4
2,3-hexanedione                3848-24-6
furfural acetone               623-15-4
trans beta-(2-furyl)acrolein   623-30-3
carveol                        99-48-9
Methyl nicotinate              93-60-7
Ethyl benzoylacetate           94-02-0
Methyl 4-methoxybenzoate       121-98-2
Levulinic acid                 123-76-2
m-Dimethoxybenzene             151-10-0
2-acetylpyridine               1122-62-9
tetramethyl-pyrazine           1124-11-4
2,3-dimethyl-pyrazine          5910-89-4
trimethyl-pyrazine             14667-55-1
2-ethyl-3-methyl-pyrazine      15707-23-0
5-Methyl-3H-furan-2-one        591-12-8
2-Methoxy-4-methylphenol       93-51-6
piperazine                     110-85-0
2-Methoxy-4-propylphenol       2785-87-7
Naphthalene, 2-(2-             2173-57-1
methylpropoxy)-
2-Acetyl-1-methylpyrrole       932-16-1
3,3-Dimethylacrylic acid       541-47-9
Ethyl sorbate                  2396-84-1
4-(4-Hydroxyphenyl)-2-butanone 5471-51-2
4-Methoxyphenylacetone         122-84-9
(−)-Myrtenal                   564-94-3
3-Phenylpropionaldehyde        104-53-0
1-Phenylethyl propionate       120-45-6
2-Methyltetrahydrofuran-3-one  3188-00-9
Cinnamyl acetate               103-54-8
Styrallyl acetate              93-92-5
Ethyl 4-methoxybenzoate        94-30-4
Benzyl propionate              122-63-4
Phenylpyruvate                 156-06-9
furaneol                       3658-77-3
methyl 2-methylbutanoate       868-57-5
Benzeneacetaldehyde, alpha-    93-53-8
methyl-
Dimethyl anthranilate          85-91-6
1,1-Dimethoxy-2-phenylpropane  90-87-9
4-hexanolide                   695-06-7
Dimethylbenzylcarbinyl acetate 151-05-3
Benzyl isobutyrate             103-28-6
Acetyl isoeugenol              93-29-8
2-Acetyl-5-methyl furan        1193-79-9
Alpha-methyl-p-                103-95-7
isopropylphenylpropanaldehyde
Benzylcarbinyl formate         104-62-1
p-Cresyl alpha-toluate         101-94-0
Potassium bisulfate            7646-93-7
Potassium carbonate            584-08-7
Potassium chloride             7447-40-7
Potassium hydroxide            1310-58-3
Ethyl tiglate                  5837-78-5
Nerol oxide                    1786-08-9
DL-Tetrohydrofurfuryl          637-65-0
propionate
Benzaldehyde propylene glycol  2568-25-4
acetal
2-Methyl-3-(2-furyl) acrolein  874-66-8
vanillin                       121-33-5
Cholic acid                    81-25-4
R-Carvone                      6485-40-1
Potassium nitrate              7757-79-1
Potassium permanganate         7722-64-7
Potassium persulfate           7727-21-1
Potassium phosphate, dibasic   2139900
Potassium Phosphate Monobasic  7778-77-0
Potassium sulfate              7778-80-5
Sodium bicarbonate             144-55-8
Sodium bisulfite               7631-90-5
Sodium carbonate               497-19-8
Sodium chloride                7647-14-5
Sodium dithionite              7775-14-6
Sodium hydroxide               1310-73-2
Sodium nitrite                 7632-00-0
Sodium Pyrophosphate           7722-88-5
Sodium sulfate                 7757-82-6
Sodium sulfite                 7757-83-7
Sodium thiocyanate             540-72-7
Calcium Carbonate              471-34-1
Calcium chloride               10043-52-4
Calcium gluconate              299-28-5
Calcium hydroxide              1305-62-0
Calcium phosphate, dibasic     7757-93-9
Calcium sulfate                7778-18-9
N-Methyl-D-glucamine           6284-40-8
Calcium oxide                  1305-78-8
Calcium Phosphate Monobasic    7758-23-8
Magnesium chloride hexahydrate 7791-18-6
Magnesium sulfate              7487-88-9
Magnesium Sulfate Heptahydrate 10034-99-8
Aluminum chloride hexahydrate  7784-13-6
aluminum nitrate nonahydrate   7784-27-2
Aluminum potassium sulfate,    7784-24-9
dodecahydrate
Aluminum sulfate,              7784-31-8
octadecahydrate
(S)-(−)-Cysteine               52-90-4
p-Toluenesulfonic Acid         104-15-4
Potassium bitartrate           868-14-4
DL-aspartic acid               617-45-8
p-Dimethylaminobenzaldehyde    100-10-7
Sodium salicylate              54-21-7
Benzoin                        119-53-9
Sodium dodecyl sulfate         151-21-3
L-Menthol                      2216-51-5
Tiron                          149-45-1
Riboflavin                     83-88-5
Sodium Acetate Trihydrate      6131-90-4
Disodium Succinate Hexahydrate 6106-21-4
Disodium                       6381-92-6
ethylenediaminetetraacetate
dihydrate
sodium citrate, dihydrate      1545801
Sodium potassium tartrate,     6381-59-5
tetrahydrate
L-(+)-Arginine                 1119-34-2
monohydrochloride
Ethylenediamine                333-18-6
dihydrochloride
Sodium formate                 141-53-7
Sodium acetate                 127-09-3
Potassium acetate              127-08-2
Ammonium citrate               3012-65-5
Ammonium bicarbonate           1066-33-7
Ammonium chloride              12125-02-9
Ammonium nitrate               6484-52-2
Ammonium persulfate            7727-54-0
Ammonium sulfate               7783-20-2
Zinc chloride                  7646-85-7
Sulfuric acid, zinc salt       7446-20-0
(1:1), heptahydrate
Sodium Tripolyphosphate        7758-29-4
ammonium benzoate              1863-63-4
ammonium bisulfite             10192-30-0
1,5-Naphthalenedisulfonic Acid 1655-29-4
Disodium Salt
4-Hydroxybenzoic Acid          99-96-7
Diphenylacetic Acid            117-34-0
Glutaric Acid                  110-94-1
L-(−)-Fucose                   2438-80-4
L-Cysteine Hydrochloride       52-89-1
L-Histidine Hydrochloride      1880304
Monohydrate
o-Toluic Acid                  118-90-1
Pivalic Acid                   75-98-9
Pyruvic Acid Sodium Salt       113-24-6
Potassium bromide              2139626
Sodium Dithionate Dihydrate    7631-94-9
Sodium Malonate                141-95-7
Trisodium Citrate              68-04-2
Potassium Sodium Tartrate      304-59-6
Potassium Citrate              866-84-2
D-Maltose Monohydrate          6363-53-7
Cyclohexaamylose               10016-20-3
Dodecyl sulfate, lithium salt  2044-56-6
Manganese chloride             2145076
methyl-urea                    598-50-5
beta-Cyclodextrin              7585-39-9
Triphosphoric acid,            13845-36-8
pentapotassium salt
Glycine ethyl ester            623-33-6
hydrochloride
L-Histidine methyl ester       7389-87-9
dihydrochloride
L-Leucine methyl ester         7517-19-3
hydrochloride
D-Lysine hydrochloride         7274-88-6
2 -Naphthalenesulfonic acid    532-02-5
sodium salt
calcium nitrate tetrahydrate   13477-34-4
Vitamin B1                     59-43-8
Zinc Acetate Dihydrate         5970-45-6
Potassium fluoride             7789-23-3
Potassium iodate               2139718
Potassium iodide               7681-11-0
Potassium thiocyanate          333-20-0
Sodium bromide                 7647-15-6
Sodium fluoride                7681-49-4
Sodium iodide                  7681-82-5
Sodium nitrate                 7631-99-4
Calcium acetate                5743-26-0
Trichloroacetic acid           76-03-9
Ammonium acetate               631-61-8
Ammonium fluoride              12125-01-8
DL-malic acid                  617-48-1
t-Butyl Alcohol                75-65-0
beta-Alanine                   107-95-9
(S)-(−)-Tryptophan             73-22-3
Malonic acid                   141-82-2
Phenethylamine                 64-04-0
Salicylylaldehyde              90-02-8
Sodium benzoate                532-32-1
Mandelic acid                  90-64-2
Calcium pantothenate           137-08-6
Chloroacetic Acid              79-11-8
Ethanol Amine                  141-43-5
Salicylic acid                 69-72-7
Saccharin sodium               128-44-9
Thiamine hydrochloride         67-03-8
2,2′-Oxybisethanol             111-46-6
Resorcinol                     108-46-3
2-Amino-2-(hydroxymethyl)-1,3- 77-86-1
propanediol
2,5-Dimethylphenol             95-87-4
Ammonium Phosphate Monobasic   7722-76-1
1,3-Butanediol                 107-88-0
Glycolic Acid                  79-14-1
Sodium Gluconate               527-07-1
Terephthalic Acid              100-21-0
L-Ascorbic Acid Sodium Salt    134-03-2
3-Acetyl-6-methyl-2,4-         520-45-6
pyrandione
Calcium Acetate                62-54-4
Nicotinamide                   98-92-0
1-Hydroxy-2-naphthoic Acid     86-48-6
2-Isopropylphenol              88-69-7
4-Aminosalicylic Acid          65-49-6
Calcium Glycerophosphate       27214-00-2
Erythorbic Acid Sodium Salt    7378-23-6
Gluconic Acid Potassium Salt   299-27-4
Orotic Acid                    65-86-1
p-Anise Alcohol                105-13-5
Potassium Benzoate             582-25-2
Taurine                        107-35-7
Thiamine Nitrate               532-43-4
3,3,5-Trimethyl-1-cyclohexanol 116-02-9
tert-Butylhydroquinone         1948-33-0
Sulfosalicylic acid            97-05-2
Gallic acid                    149-91-7
L-borneol                      464-45-9
Isoborneol                     124-76-5
2,5-Dihydroxybenzoic acid,     490-79-9
Gentisic acid
5-hydroxy-6-methyl-3,4-        65-23-6
pyridinedimethanol
Naphthalene-2-sulfonic acid    120-18-3
Ethanesulfonic acid, 2-        1562-00-1
hydroxy-, monosodium salt
Pamoic acid                    130-85-8
2,4-Dimethylphenol             105-67-9
3,5-Dihydroxyacetophenone      51863-60-6
Eugenol                        97-53-0
n-Butyric Acid                 107-92-6
Hydroquinone                   123-31-9
Propionic Acid                 79-09-4
meta-Phenylenediamine          108-45-2
Oxalic Acid                    144-62-7
n-Hexanoic Acid                142-62-1
2-Furancarboxylic Acid         88-14-2
4′-Nitroacetanilide            104-04-1
D-(−)-Tartaric Acid            147-71-7
p-Acetamidobenzoic Acid        556-08-1
Galactaric acid                526-99-8
D-glucuronate                  1700908
Lactobionic acid               96-82-2
p-Formylacetanilide            122-85-0
2-Mercaptobenzoic acid         147-93-3
Propanoic acid, 2-hydroxy-,    28305-25-1
calcium salt (2:1), (S)-
D(+)-10-Camphorsulfonic acid   3144-16-9
3-Cyclopentylpropionic acid    140-77-2
1R-(−)-Camphorsulfonic acid    35963-20-3
DL-Lysine                      70-54-2
Cinnamic acid                  621-82-9
Triethanolamine                102-71-6
Acetic Acid                    64-19-7
Dichloroacetic Acid            79-43-6
Diethylamine                   109-89-7
Diethylaminoethanol            100-37-8
N-(2-Hydroxyethyl)Morpholine   622-40-2
Octanoic Acid                  124-07-2
isobutyric acid                79-31-2
Anisic Acid                    100-09-4
Betaine                        107-43-7
Enanthoic Acid                 111-14-8
Hippuric Acid                  495-69-2
Tiglic Acid                    80-59-1
Cyclohexanecarboxylic acid     98-89-5
m-Methoxybenzoic acid          586-38-9
D-(+)-Camphoric acid           124-83-4
N-(2-Hydroxyethyl)pyrrolidine  2955-88-6
Name—                          CAS #
Sodium Metabisulfite           7681-57-4
sodium hydrogen phosphate      7558-79-4
Sodium Phosphate Monobasic     7558-80-7
Sodium thiosulfate             7772-98-71
Orthoboric acid                10043-35-3
Diethanolamine                 111-42-2
Benzaldehyde                   100-52-7
Sorbic acid                    110-44-1
L-(+)-Tartaric Acid            87-69-4
D-mannitol                     69-65-8
Butyl paraben                  94-26-8
Thymol                         89-83-8
Methyl salicylate              119-36-8
Citric acid                    77-92-9
Creatinine                     60-27-5
Vitamin C                      50-81-7
Benzoic Acid                   65-85-0
Methyl 4-hydroxybenzoate       99-76-3
m-Cresol                       108-39-4
p-Cresol                       106-44-5
Aspirin                        50-78-2
Phenol                         108-95-2
Sucrose                        57-50-1
Potassium citrate, monohydrate 1534146
Name                           CAS #
Sodium acetate                 127-09-3
Lactic acid                    50-21-5
Propionic acid, sodium salt    65-85
Benzyl alcohol                 100-51-6
Phenethyl alcohol              60-12-8
Cholesterol                    57-88-5
D-Glucose                      50-99-7
Sorbitol                       50-70-4
Aspartame                      22839-47-0
Saccharin                      81-07-2
2,6-Di-tert-Butyl-p-Cresol     128-37-0
4-Chloro-3-methylphenol        59-50-7
glycerin                       56-81-5
Propyl paraben                 94-13-3
fumaric acid                   110-17-8
dabco                          280-57-9
p-Phenylenediamine             106-50-3
Anethole                       4180-23-8
propyl gallate                 121-79-9
L-monosodium glutamate         142-47-2
Butylated hydroxyanisole       25013-16-5
Cyclohexanol, 5-methyl-2-(1-   89-78-1
methylethyl)-,
(1alpha,2beta,5alpha)-
alpha-Thioglycerol             96-27-5
Sodium dehydroacetate          4418-26-2
Ethyl 4-hydroxybenzoate        120-47-8
Ethyl Vanillin                 121-32-4
Triacetin                      102-76-1
Potassium sorbate              590-00-1
Triethyl citrate               77-93-0
(S)-(+)-Arginine               74-79-3
Glycine                        56-40-6
(S)-(−)-Histidine              71-00-1
(S)-(+)-Lysine                 56-87-1
Quinone                        106-51-4
Naphthalene, 2-ethoxy-         93-18-5
Methanesulfonic Acid           75-75-2
DL-Tartaric Acid               133-37-9
Cyclamic acid                  100-88-9
(S)-(−)-Phenylalanine          63-91-2
(S)-(−)-Tyrosine               60-18-4
Carvone                        99-49-0
Ethyl butyrate                 105-54-4
6-Methyl-5-hepten-2-one        110-93-0
Ethyl acetoacetate             141-97-9
Methyl benzoate                93-58-3
Phenylacetic Acid              103-82-2
Adipic acid                    124-04-9
Ethyl benzoate                 93-89-0
Benzyl benzoate                120-51-4
Pyruvic acid                   127-17-3
Succinic acid                  110-15-6
Indole                         120-72-9
Methyl anthranilate            134-20-3
Diethyl malonate               105-53-3
Niacin                         59-67-6
Meso-inositol                  87-89-8
4-Aminobenzoic acid            150-13-0
Anisole                        100-66-3
Urea                           57-13-6
Pyrrolidine                    123-75-1
Cyclopentanone                 120-92-3
Acetic anhydride               108-24-7
Benzophenone                   119-61-9
D-(−)-Fructose                 57-48-7
D-(+)-Xylose                   58-86-6
o-Methoxybenzoic Acid          579-75-9
linalool                       78-70-6
ethyl isovalerate              108-64-5
1,1′-Azobisformamide           123-77-3
6-Methylcoumarin               92-48-8
acetoin                        513-86-0
alpha-Phellandrene             99-83-2
Cymene                         99-87-6
Dimethyl Succinate             106-65-0
p-Anisaldehyde                 123-11-5
Phenyl ether                   101-84-8
Tetrahydro-2-furanmethanol     97-99-4
Valeric Acid                   109-52-4
3,4-xylenol                    95-65-8
1,1-diethoxyethane             105-57-7
ethyl butyraldehyde            97-96-1
Ethyl crotonate                623-70-1
ethyl isobutyrate              97-62-1
methyl isovalerate             556-24-1
methyl propionate              554-12-1
methyl valeraldehyde           123-15-9
4-(2,6,6-Trimethyl-2-          127-41-3
cyclohexen-1-yl)-3-buten-2-one
4-(2,6,6-trimethyl-1-          14901-07-6
cyclohexen-1-yl)-3-buten-2-one
Maleic acid                    110-16-7
3-Methylbutanoic acid          503-74-2
L-Glutamic Acid                56-86-0
D-limonene                     5989-27-5
1-Phenyl-1-propanol            93-54-9
2′-Hydroxyacetophenone         118-93-4
2,4-Dihydroxybenzoic Acid      89-86-1
2-Phenyl-1-propanol            1123-85-9
3-Phenylpropionic Acid         501-52-0
4-Ethoxyphenol                 622-62-8
Alpha-Terpineol                98-55-5
Benzaldehyde Dimethylacetal    1125-88-8
Benzyl Ether                   103-50-4
Benzyl Formate                 104-57-4
Benzyl Salicylate              118-58-1
Cinnamyl Alcohol               104-54-1
D-(+)-Glucono-1,5-lactone      4253-68-3
D-Isoascorbic Acid             89-65-6
2,3-Naphthalenediol            92-44-4
Diethyl Succinate              123-25-1
Ethyl 2-Aminobenzoate          87-25-2
Ethyl Cinnamate                103-36-6
Ethyl Phenylacetate            101-97-3
Ethyl Salicylate               118-61-6
gamma-Valerolactone            108-29-2
Hydroquinone Dimethyl Ether    150-78-7
Isocaproic Acid                646-07-1
Isoeugenol                     97-54-1
Isopropyl Benzoate             939-48-0
L-(+)-Isoleucine               73-32-5
L-Malic acid                   97-67-6
L-2-Aminopropionic Acid        56-41-7
L-Carnitine                    541-15-1
L-Glutamine                    56-85-9
L-Hydroxyproline               51-35-4
L-Proline                      147-85-3
L-Serine                       56-45-1
L-Threonine                    72-19-5
L-Valine                       72-18-4
Phenoxyacetic Acid             122-59-8
Veratrole                      91-16-7
2-Ethylbutyric acid            88-09-5
2-Methylpyrazine               109-08-0
o-methoxybenzaldehyde          135-02-4
L-Leucine                      61-90-5
L-Asparagine                   70-47-3
propiophenone                  93-55-0
5-isopropyl-2-methyl-phenol    499-75-2
Xylitol                        87-99-0
ethyl 4-oxopentanoate          539-88-8
methyl cinnamate               103-26-4
cumic alcohol                  536-60-7
methyl 2-naphthyl ketone       93-08-3
1-methyl-4-(1-methylethyl)-    99-85-4
1,4-Cyclohexadiene
en —ethylene diamine
Caffeine                       58-08-2
5-methylfurfural               620-02-0
furfuryl acetate               623-17-6
terpinen-4-ol                  10482-56-1
phenylethanal                  122-78-1
4′-Methoxyacetophenone         100-06-1
D-Fenchone                     4695-62-9
1-Methoxy-4-methylbenzene      104-93-8
o-methylanisole                578-58-5
Acetylacetaldehyde dimethyl    5436-21-5
acetal
p-methylacetophenone           122-00-9
Methyl phenylacetate           101-41-7
4-Ethoxybenzaldehyde           10031-82-0
p-tolyl acetate                140-39-6
2,6-Dimethoxyphenol            91-10-1
Methyl 2-methoxybenzoate       606-45-1
alpha-methylcinnamaldehyde     101-39-3
2-methoxycinnamaldehyde        60125-24-8
Potassium bicarbonate          298-14-6
piperonyl acetate              326-61-4
2,3-hexanedione                3848-24-6
furfural acetone               623-15-4
trans beta-(2-furyl)acrolein   623-30-3
carveol                        99-48-9
Methyl nicotinate              93-60-7
Ethyl benzoylacetate           94-02-0
Methyl 4-methoxybenzoate       121-98-2
Levulinic acid                 123-76-2
m-Dimethoxybenzene             151-10-0
2-acetylpyridine               1122-62-9
tetramethyl-pyrazine           1124-11-4
2,3-dimethyl-pyrazine          5910-89-4
trimethyl-pyrazine             14667-55-1
2-ethyl-3-methyl-pyrazine      15707-23-0
5-Methyl-3H-furan-2-one        591-12-8
2-Methoxy-4-methylphenol       93-51-6
piperazine                     110-85-0
2-Methoxy-4-propylphenol       2785-87-7
Naphthalene,2-(2-              2173-57-1
methylpropoxy)-
2-Acetyl-1-methylpyrrole       932-16-1
3,3-Dimethylacrylic acid       541-47-9
Ethyl sorbate                  2396-84-1
4-(4-Hydroxyphenyl)-2-butanone 5471-51-2
4-Methoxyphenylacetone         122-84-9
(−)-Myrtenal                   564-94-3
3-Phenylpropionaldehyde        104-53-0
1-Phenylethyl propionate       120-45-6
2-Methyltetrahydrofuran-3-one  3188-00-9
Cinnamyl acetate               103-54-8
Styrallyl acetate              93-92-5
Ethyl 4-methoxybenzoate        94-30-4
Benzyl propionate              122-63-4
Phenylpyruvate                 156-06-9
furaneol                       3658-77-3
methyl 2-methylbutanoate       868-57-5
Benzeneacetaldehyde, alpha-    93-53-8
methyl-
Dimethyl anthranilate          85-91-6
1,1-Dimethoxy-2-phenylpropane  90-87-9
4-hexanolide                   695-06-7
Dimethylbenzylcarbinyl acetate 151-05-3
Benzyl isobutyrate             103-28-6
Acetyl isoeugenol              93-29-8
2-Acetyl-5-methyl furan        1193-79-9
Alpha-methyl-p                 103-95-7
isopropylphenylpropanaldehyde
Benzylcarbinyl formate         104-62-1
p-Cresyl alpha-toluate         101-94-0
Potassium bisulfate            7646-93-7
Potassium carbonate            584-08-7
Potassium chloride             7447-40-7
Potassium hydroxide            1310-58-3
Ethyl tiglate                  5837-78-5
Nerol oxide                    1786-08-9
DL-Tetrohydrofurfuryl          637-65-0
propionate
Benzaldehyde propylene glycol  2568-25-4
acetal
2-Methyl-3-(2-furyl) acrolein  874-66-8
vanillin                       121-33-5
Cholic acid                    81-25-4
R-Carvone                      6485-40-1
Potassium nitrate              7757-79-1
Potassium permanganate         7722-64-7
Potassium persulfate           7727-21-1
Potassium phosphate, dibasic   2139900
Potassium Phosphate Monobasic  7778-77-0
Potassium sulfate              7778-80-5
Sodium bicarbonate             144-55-8
Sodium bisulfite               7631-90-5
Sodium carbonate               497-19-8
Sodium chloride                7647-14-5
Sodium dithionite              7775-14-6
Sodium hydroxide               1310-73-2
Sodium nitrite                 7632-00-0
Sodium Pyrophosphate           7722-88-5
Sodium sulfate                 7757-82-6
Sodium sulfite                 7757-83-7
Sodium thiocyanate             540-72-7
Calcium Carbonate              471-34-1
Calcium chloride               10043-52-4
Calcium gluconate              299-28-5
Calcium hydroxide              1305-62-0
Calcium phosphate, dibasic     7757-93-9
Calcium sulfate                7778-18-9
N-Methyl-D-glucamine           6284-40-8
Calcium oxide                  1305-78-8
Calcium Phosphate Monobasic    7758-23-8
Magnesium chloride hexahydrate 7791-18-6
Magnesium sulfate              7487-88-9
Magnesium Sulfate Heptahydrate 10034-99-8
Aluminum chloride hexahydrate  7784-13-6
aluminum nitrate nonahydrate   7784-27-2
Aluminum potassium sulfate,    7784-24-9
dodecahydrate
Aluminum sulfate,              7784-31-8
octadecahydrate
(S)-(−)-Cysteine               52-90-4
p-Toluenesulfonic Acid         104-15-4
Potassium bitartrate           868-14-4
DL-aspartic acid               617-45-8
p-Dimethylaminobenzaldehyde    100-10-7
Sodium salicylate              54-21-7
Benzoin                        119-53-9
Sodium dodecyl sulfate         151-21-3
L-Menthol                      2216-51-5
Tiron                          149-45-1
Riboflavin                     83-88-5
Sodium Acetate Trihydrate      6131-90-4
Disodium Succinate Hexahydrate 6106-21-4
Disodium                       6381-92-6
ethylenediaminetetraacetate
dihydrate
sodium citrate, dihydrate      1545801
Sodium potassium tartrate,     6381-59-5
tetrahydrate
L-(+)-Arginine                 1119-34-2
monohydrochloride
Ethylenediamine                333-18-6
dihydrochloride
Sodium formate                 141-53-7
Sodium acetate                 127-09-3
Potassium acetate              127-08-2
Ammonium citrate               3012-65-5
Ammonium bicarbonate           1066-33-7
Ammonium chloride              12125-02-9
Ammonium nitrate               6484-52-2
Ammonium persulfate            7727-54-0
Ammonium sulfate               7783-20-2
Zinc chloride                  7646-85-7
Sulfuric acid, zinc salt       7446-20-0
(1:1), heptahydrate
Sodium Tripolyphosphate        7758-29-4
ammonium benzoate              1863-63-4
ammonium bisulfite             10192-30-0
1,5-Naphthalenedisulfonic Acid 1655-29-4
Disodium Salt
4-Hydroxybenzoic Acid          99-96-7
Diphenylacetic Acid            117-34-0
Glutaric Acid                  110-94-1
L-(−)-Fucose                   2438-80-4
L-Cysteine Hydrochloride       52-89-1
L-Histidine Hydrochloride      1880304
Monohydrate
o-Toluic Acid                  118-90-1
Pivalic Acid                   75-98-9
Pyruvic Acid Sodium Salt       113-24-6
Potassium bromide              2139626
Sodium Dithionate Dihydrate    7631-94-9
Sodium Malonate                141-95-7
Trisodium Citrate              68-04-2
Potassium Sodium Tartrate      304-59-6
Potassium Citrate              866-84-2
D-Maltose Monohydrate          6363-53-7
Cyclohexaamylose               10016-20-3
Dodecyl sulfate, lithium salt  2044-56-6
Manganese chloride             2145076
methyl-urea                    598-50-5
beta-Cyclodextrin              7585-39-9
Triphosphoric acid,            13845-36-8
pentapotassium salt
Glycine ethyl ester            623-33-6
hydrochloride
L-Histidine methyl ester       7389-87-9
dihydrochloride
L-Leucine methyl ester         7517-19-3
hydrochloride
D-Lysine hydrochloride         7274-88-6
2-Naphthalenesulfonic acid     532-02-5
sodium salt
calcium nitrate tetrahydrate   13477-34-4
Vitamin B1                     59-43-8
Zinc Acetate Dihydrate         5970-45-6
Potassium fluoride             7789-23-3
Potassium iodate               2139718
Potassium iodide               7681-11-0
Potassium thiocyanate          333-20-0
Sodium bromide                 7647-15-6
Sodium fluoride                7681-49-4
Sodium iodide                  7681-82-5
Sodium nitrate                 7631-99-4
Calcium acetate                5743-26-0
Trichloroacetic acid           76-03-9
Ammonium acetate               631-61-8
Ammonium fluoride              12125-01-8
DL-malic acid                  617-48-1
t-Butyl Alcohol                75-65-0
beta-Alanine                   107-95-9
(S)-(−)-Tryptophan             73-22-3
Malonic acid                   141-82-2
Phenethylamine                 64-04-0
Salicylylaldehyde              90-02-8
Sodium benzoate                532-32-1
Mandelic acid                  90-64-2
Calcium pantothenate           137-08-6
Chloroacetic Acid              79-11-8
Ethanol Amine                  141-43-5
Salicylic acid                 69-72-7
Saccharin sodium               128-44-9
Thiamine hydrochloride         67-03-8
2,2′-Oxybisethanol             111-46-6
Resorcinol                     108-46-3
2-Amino-2-(hydroxymethyl)-1,3- 77-86-1
propanediol
2,5-Dimethylphenol             95-87-4
Ammonium Phosphate Monobasic   7722-76-1
1,3-Butanediol                 107-88-0
Glycolic Acid                  79-14-1
Sodium Gluconate               527-07-1
Terephthalic Acid              100-21-0
L-Ascorbic Acid Sodium Salt    134-03-2
3-Acetyl-6-methyl-2,4-         520-45-6
pyrandione
Calcium Acetate                62-54-4
Nicotinamide                   98-92-0
1-Hydroxy-2-naphthoic Acid     86-48-6
2-Isopropylphenol              88-69-7
4-Aminosalicylic Acid          65-49-6
Calcium Glycerophosphate       27214-00-2
Erythorbic Acid Sodium Salt    7378-23-6
Gluconic Acid Potassium Salt   299-27-4
Orotic Acid                    65-86-1
p-Anise Alcohol                105-13-5
Potassium Benzoate             582-25-2
Taurine                        107-35-7
Thiamine Nitrate               532-43-4
3,3,5-Trimethyl-1-cyclohexanol 116-02-9
tert-Butylhydroquinone         1948-33-0
Sulfosalicylic acid            97-05-2
Gallic acid                    149-91-7
L-borneol                      464-45-9
Isoborneol                     124-76-5
2,5-Dihydroxybenzoic acid,     490-79-9
Gentisic acid
5-hydroxy-6-methyl-3,4-        65-23-6
pyridinedimethanol
Naphthalene-2-sulfonic acid    120-18-3
Ethanesulfonic acid, 2-        1562-00-1
hydroxy-, monosodium salt
Pamoic acid                    130-85-8
2,4-Dimethylphenol             105-67-9
3,5-Dihydroxyacetophenone      51863-60-6
Eugenol                        97-53-0
n-Butyric Acid                 107-92-6
Hydroquinone                   123-31-9
Propionic Acid                 79-09-4
meta-Phenylenediamine          108-45-2
Oxalic Acid                    144-62-7
n-Hexanoic Acid                142-62-1
2-Furancarboxylic Acid         88-14-2
4′-Nitroacetanilide            104-04-1
D-(−)-Tartaric Acid            147-71-7
p-Acetamidobenzoic Acid        556-08-1
Galactaric acid                526-99-8
D-glucuronate                  1700908
Lactobionic acid               96-82-2
p-Formylacetanilide            122-85-0
2-Mercaptobenzoic acid         147-93-3
Propanoic acid, 2-hydroxy-,    28305-25-1
calcium salt (2:1), (S)-
D(+)-10-Camphorsulfonic acid   3144-16-9
3-Cyclopentylpropionic acid    140-77-2
1R-(−)-Camphorsulfonic acid    35963-20-3
DL-Lysine                      70-54-2
Cinnamic acid                  621-82-9
Triethanolamine                102-71-6
Acetic Acid                    64-19-7
Dichloroacetic Acid            79-43-6
Diethylamine                   109-89-7
Diethylaminoethanol            100-37-8
N-(2-Hydroxyethyl)Morpholine   622-40-2
Octanoic Acid                  124-07-2
isobutyric acid                79-31-2
Anisic Acid                    100-09-4
Betaine                        107-43-7
Enanthoic Acid                 111-14-8
Hippuric Acid                  495-69-2
Tiglic Acid                    80-59-1
Cyclohexanecarboxylic acid     98-89-5
m-Methoxybenzoic acid          586-38-9
D-(+)-Camphoric acid           124-83-4
N-(2-Hydroxyethyl)pyrrolidine  2955-88-6
Name—                          CAS #
Sodium Metabisulfite           7681-57-4
sodium hydrogen phosphate      7558-79-4
Sodium Phosphate Monobasic     7558-80-7
Sodium thiosulfate             7772-98-71
Orthoboric acid                10043-35-3
Diethanolamine                 111-42-2
Benzaldehyde                   100-52-7
Sorbic acid                    110-44-1
L-(+)-Tartaric Acid            87-69-4
D-mannitol                     69-65-8
Butyl paraben                  94-26-8
Thymol                         89-83-8
Methyl salicylate              119-36-8
Citric acid                    77-92-9
Creatinine                     60-27-5
Vitamin C                      50-81-7
Benzoic Acid                   65-85-0
Methyl 4-hydroxybenzoate       99-76-3
Name                           CAS #
m-Cresol                       108-39-4
p-Cresol                       106-44-5
Aspirin                        50-78-2
Phenol                         108-95-2
Sucrose                        57-50-1
Potassium citrate, monohydrate 1534146
Sodium acetate                 127-09-3
Lactic acid                    50-21-5
Propionic acid, sodium salt    65-85
Benzyl alcohol                 100-51-6
Phenethyl alcohol              60-12-8
Cholesterol                    57-88-5
D-Glucose                      50-99-7
Sorbitol                       50-70-4
Aspartame                      22839-47-0
Saccharin                      81-07-2
2,6-Di-tert-Butyl-p-Cresol     128-37-0
4-Chloro-3-methylphenol        59-50-7
glycerin                       56-81-5
Propyl paraben                 94-13-3
fumaric acid                   110-17-8
dabco                          280-57-9
p-Phenylenediamine             106-50-3
Anethole                       4180-23-8
propyl gallate                 121-79-9
L-monosodium glutamate         142-47-2
Butylated hydroxyanisole       25013-16-5
Cyclohexanol, 5-methyl-2-(1-   89-78-1
methylethyl)-,
(1alpha, 2beta, 5alpha)-
alpha-Thioglycerol             96-27-5
Sodium dehydroacetate          4418-26-2
Ethyl 4-hydroxybenzoate        120-47-8
Ethyl Vanillin                 121-32-4
Triacetin                      102-76-1
Potassium sorbate              590-00-1
Triethyl citrate               77-93-0
(S)-(+)-Arginine               74-79-3
Glycine                        56-40-6
(S)-(−)-Histidine              71-00-1
(S)-(+)-Lysine                 56-87-1
Quinone                        106-51-4
Naphthalene, 2-ethoxy-         93-18-5
Methanesulfonic Acid           75-75-2
DL-Tartaric Acid               133-37-9
Cyclamic acid                  100-88-9
(S)-(−)-Phenylalanine          63-91-2
(S)-(−)-Tyrosine               60-18-4
Carvone                        99-49-0
Ethyl butyrate                 105-54-4
6-Methyl-5-hepten-2-one        110-93-0
Ethyl acetoacetate             141-97-9
Methyl benzoate                93-58-3
Phenylacetic Acid              103-82-2
Adipic acid                    124-04-9
Ethyl benzoate                 93-89-0
Benzyl benzoate                120-51-4
Pyruvic acid                   127-17-3
Succinic acid                  110-15-6
Indole                         120-72-9
Methyl anthranilate            134-20-3
Diethyl malonate               105-53-3
Niacin                         59-67-6
Meso-inositol                  87-89-8
4-Aminobenzoic acid            150-13-0
Anisole                        100-66-3
Urea                           57-13-6
Pyrrolidine                    123-75-1
Cyclopentanone                 120-92-3
Acetic anhydride               108-24-7
Benzophenone                   119-61-9
D-(−)-Fructose                 57-48-7
D-(+)-Xylose                   58-86-6
o-Methoxybenzoic Acid          579-75-9
linalool                       78-70-6
ethyl isovalerate              108-64-5
1,1′-Azobisformamide           123-77-3
6-Methylcoumarin               92-48-8
acetoin                        513-86-0
alpha-Phellandrene             99-83-2
Cymene                         99-87-6
Dimethyl Succinate             106-65-0
p-Anisaldehyde                 123-11-5
Phenyl ether                   101-84-8
Tetrahydro-2-furanmethanol     97-99-4
Valeric Acid                   109-52-4
3,4-xylenol                    95-65-8
1,1-diethoxyethane             105-57-7
ethyl butyraldehyde            97-96-1
Ethyl crotonate                623-70-1
ethyl isobutyrate              97-62-1
methyl isovalerate             556-24-1
methyl propionate              554-12-1
methyl valeraldehyde           123-15-9
4-(2,6,6-Trimethyl-2-          127-41-3
cyclohexen-1-yl)-3-buten-2-one
4-(2,6,6-trimethyl-1-          14901-07-6
cyclohexen-1-yl)-3-buten-2-one
Maleic acid                    110-16-7
3-Methylbutanoic acid          503-74-2
L-Glutamic Acid                56-86-0
D-limonene                     5989-27-5
1-Phenyl-1-propanol            93-54-9
2′-Hydroxyacetophenone         118-93-4
2,4-Dihydroxybenzoic Acid      89-86-1
2-Phenyl-1-propanol            1123-85-9
3-Phenylpropionic Acid         501-52-0
4-Ethoxyphenol                 622-62-8
Alpha-Terpineol                98-55-5
Benzaldehyde Dimethylacetal    1125-88-8
Benzyl Ether                   103-50-4
Benzyl Formate                 104-57-4
Benzyl Salicylate              118-58-1
Cinnamyl Alcohol               104-54-1
D-(+)-Glucono-1,5-lactone      4253-68-3
D-Isoascorbic Acid             89-65-6
2,3-Naphthalenediol            92-44-4
Diethyl Succinate              123-25-1
Ethyl 2-Aminobenzoate          87-25-2
Ethyl Cinnamate                103-36-6
Ethyl Phenylacetate            101-97-3
Ethyl Salicylate               118-61-6
gamma-Valerolactone            108-29-2
Hydroquinone Dimethyl Ether    150-78-7
Isocaproic Acid                646-07-1
Isoeugenol                     97-54-1
Isopropyl Benzoate             939-48-0
L-(+)-Isoleucine               73-32-5
L-Malic acid                   97-67-6
L-2-Aminopropionic Acid        56-41-7
L-Carnitine                    541-15-1
L-Glutamine                    56-85-9
L-Hydroxyproline               51-35-4
L-Proline                      147-85-3
L-Serine                       56-45-1
L-Threonine                    72-19-5
L-Valine                       72-18-4
Phenoxyacetic Acid             122-59-8
Veratrole                      91-16-7
2-Ethylbutyric acid            88-09-5
2-Methylpyrazine               109-08-0
o-methoxybenzaldehyde          135-02-4
L-Leucine                      61-90-5
L-Asparagine                   70-47-3
propiophenone                  93-55-0
5-isopropyl-2-methyl-phenol    499-75-2
Xylitol                        87-99-0
ethyl 4-oxopentanoate          539-88-8
methyl cinnamate               103-26-4
cumic alcohol                  536-60-7
methyl 2-naphthyl ketone       93-08-3
1-methyl-4-(1-methylethyl)-    99-85-4
1,4-Cyclohexadiene
en-ethylene diamine
Caffeine                       58-08-2
5-methylfurfural               620-02-0
furfuryl acetate               623-17-6
terpinen-4-ol                  10482-56-1
phenylethanal                  122-78-1
4′-Methoxyacetophenone         100-06-1
D-Fenchone                     4695-62-9
1-Methoxy-4-methylbenzene      104-93-8
o-methylanisole                578-58-5
Acetylacetaldehyde dimethyl    5436-21-5
acetal
p-methylacetophenone           122-00-9
Methyl phenylacetate           101-41-7
4-Ethoxybenzaldehyde           10031-82-0
p-tolyl acetate                140-39-6
2,6-Dimethoxyphenol            91-10-1
Methyl 2-methoxybenzoate       606-45-1
alpha-methylcinnamaldehyde     101-39-3
2-methoxycinnamaldehyde        60125-24-8
Potassium bicarbonate          298-14-6
piperonyl acetate              326-61-4
2,3-hexanedione                3848-24-6
furfural acetone               623-15-4
trans beta-(2-furyl)acrolein   623-30-3
carveol                        99-48-9
Methyl nicotinate              93-60-7
Ethyl benzoylacetate           94-02-0
Methyl 4-methoxybenzoate       121-98-2
Levulinic acid                 123-76-2
m-Dimethoxybenzene             151-10-0
2-acetylpyridine               1122-62-9
tetramethyl-pyrazine           1124-11-4
2,3-dimethyl-pyrazine          5910-89-4
trimethyl-pyrazine             14667-55-1
2-ethyl-3-methyl-pyrazine      15707-23-0
5-Methyl-3H-furan-2-one        591-12-8
2-Methoxy-4-methylphenol       93-51-6
piperazine                     110-85-0
2-Methoxy-4-propylphenol       2785-87-7
Naphthalene, 2-(2-             2173-57-1
methylpropoxy)-
2-Acetyl-1-methylpyrrole       932-16-1
3,3-Dimethylacrylic acid       541-47-9
Ethyl sorbate                  2396-84-1
4-(4-Hydroxyphenyl)-2-butanone 5471-51-2
4-Methoxyphenylacetone         122-84-9
(−)-Myrtenal                   564-94-3
3-Phenylpropionaldehyde        104-53-0
1-Phenylethyl propionate       120-45-6
2-Methyltetrahydrofuran-3-one  3188-00-9
Cinnamyl acetate               103-54-8
Styrallyl acetate              93-92-5
Ethyl 4-methoxybenzoate        94-30-4
Benzyl propionate              122-63-4
Phenylpyruvate                 156-06-9
furaneol                       3658-77-3
methyl 2-methylbutanoate       868-57-5
Benzeneacetaldehyde, alpha-    93-53-8
methyl-
Dimethyl anthranilate          85-91-6
1,1-Dimethoxy-2-phenylpropane  90-87-9
4-hexanolide                   695-06-7
Dimethylbenzylcarbinyl acetate 151-05-3
Benzyl isobutyrate             103-28-6
Acetyl isoeugenol              93-29-8
2-Acetyl-5-methyl furan        1193-79-9
Alpha-methyl-p-                103-95-7
isopropylphenylpropanaldehyde
Benzylcarbinyl formate         104-62-1
p-Cresyl alpha-toluate         101-94-0
Potassium bisulfate            7646-93-7
Potassium carbonate            584-08-7
Potassium chloride             7447-40-7
Potassium hydroxide            1310-58-3
Ethyl tiglate                  5837-78-5
Nerol oxide                    1786-08-9
DL-Tetrohydrofurfuryl          637-65-0
propionate
Benzaldehyde propylene glycol  2568-25-4
acetal
2-Methyl-3-(2-furyl) acrolein  874-66-8
vanillin                       121-33-5
Cholic acid                    81-25-4
R-Carvone                      6485-40-1
Potassium nitrate              7757-79-1
Potassium permanganate         7722-64-7
Potassium persulfate           7727-21-1
Potassium phosphate, dibasic   2139900
Potassium Phosphate Monobasic  7778-77-0
Potassium sulfate              7778-80-5
Sodium bicarbonate             144-55-8
Sodium bisulfite               7631-90-5
Sodium carbonate               497-19-8
Sodium chloride                7647-14-5
Sodium dithionite              7775-14-6
Sodium hydroxide               1310-73-2
Sodium nitrite                 7632-00-0
Sodium Pyrophosphate           7722-88-5
Sodium sulfate                 7757-82-6
Sodium sulfite                 7757-83-7
Sodium thiocyanate             540-72-7
Calcium Carbonate              471-34-1
Calcium chloride               10043-52-4
Calcium gluconate              299-28-5
Calcium hydroxide              1305-62-0
Calcium phosphate, dibasic     7757-93-9
Calcium sulfate                7778-18-9
N-Methyl-D-glucamine           6284-40-8
Calcium oxide                  1305-78-8
Calcium Phosphate Monobasic    7758-23-8
Magnesium chloride hexahydrate 7791-18-6
Magnesium sulfate              7487-88-9
Magnesium Sulfate Heptahydrate 10034-99-8
Aluminum chloride hexahydrate  7784-13-6
aluminum nitrate nonahydrate   7784-27-2
Aluminum potassium sulfate,    7784-24-9
dodecahydrate
Aluminum sulfate,              7784-31-8
octadecahydrate
(S)-(−)-Cysteine               52-90-4
p-Toluenesulfonic Acid         104-15-4
Potassium bitartrate           868-14-4
DL-aspartic acid               617-45-8
p-Dimethylaminobenzaldehyde    100-10-7
Sodium salicylate              54-21-7
Benzoin                        119-53-9
Sodium dodecyl sulfate         151-21-3
L-Menthol                      2216-51-5
Tiron                          149-45-1
Riboflavin                     83-88-5
Sodium Acetate Trihydrate      6131-90-4
Disodium Succinate Hexahydrate 6106-21-4
Disodium                       6381-92-6
ethylenediaminetetraacetate
dihydrate
sodium citrate, dihydrate      1545801
Sodium potassium tartrate,     6381-59-5
tetrahydrate
L-(+)-Arginine                 1119-34-2
monohydrochloride
Ethylenediamine                333-18-6
dihydrochloride
Sodium formate                 141-53-7
Sodium acetate                 127-09-3
Potassium acetate              127-08-2
Ammonium citrate               3012-65-5
Ammonium bicarbonate           1066-33-7
Ammonium chloride              12125-02-9
Ammonium nitrate               6484-52-2
Ammonium persulfate            7727-54-0
Ammonium sulfate               7783-20-2
Zinc chloride                  7646-85-7
Sulfuric acid, zinc salt       7446-20-0
(1:1), heptahydrate
Sodium Tripolyphosphate        7758-29-4
ammonium benzoate              1863-63-4
ammonium bisulfite             10192-30-0
1,5-Naphthalenedisulfonic Acid 1655-29-4
Disodium Salt
4-Hydroxybenzoic Acid          99-96-7
Diphenylacetic Acid            117-34-0
Glutaric Acid                  110-94-1
L-(−)-Fucose                   2438-80-4
L-Cysteine Hydrochloride       52-89-1
L-Histidine Hydrochloride      1880304
Monohydrate
o-Toluic Acid                  118-90-1
Pivalic Acid                   75-98-9
Pyruvic Acid Sodium Salt       113-24-6
Potassium bromide              2139626
Sodium Dithionate Dihydrate    7631-94-9
Sodium Malonate                141-95-7
Trisodium Citrate              68-04-2
Potassium Sodium Tartrate      304-59-6
Potassium Citrate              866-84-2
D-Maltose Monohydrate          6363-53-7
Cyclohexaamylose               10016-20-3
Dodecyl sulfate, lithium salt  2044-56-6
Manganese chloride             2145076
methyl-urea                    598-50-5
beta-Cyclodextrin              7585-39-9
Triphosphoric acid,            13845-36-8
pentapotassium salt
Glycine ethyl ester            623-33-6
hydrochloride
L-Histidine methyl ester       7389-87-9
dihydrochloride
L-Leucine methyl ester         7517-19-3
hydrochloride
D-Lysine hydrochloride         7274-88-6
2-Naphthalenesulfonic acid     532-02-5
sodium salt
calcium nitrate tetrahydrate   13477-34-4
Vitamin B1                     59-43-8
Zinc Acetate Dihydrate         5970-45-6
Potassium fluoride             7789-23-3
Potassium iodate               2139718
Potassium iodide               7681-11-0
Potassium thiocyanate          333-20-0
Sodium bromide                 7647-15-6
Sodium fluoride                7681-49-4
Sodium iodide                  7681-82-5
Sodium nitrate                 7631-99-4
Calcium acetate                5743-26-0
Trichloroacetic acid           76-03-9
Ammonium acetate               631-61-8
Ammonium fluoride              12125-01-8
DL-malic acid                  617-48-1
t-Butyl Alcohol                75-65-0
beta-Alanine                   107-95-9
(S)-(−)-Tryptophan             73-22-3
Malonic acid                   141-82-2
Phenethylamine                 64-04-0
Salicylylaldehyde              90-02-8
Sodium benzoate                532-32-1
Mandelic acid                  90-64-2
Calcium pantothenate           137-08-6
Chloroacetic Acid              79-11-8
Ethanol Amine                  141-43-5
Salicylic acid                 69-72-7
Saccharin sodium               128-44-9
Thiamine hydrochloride         67-03-8
2,2′-Oxybisethanol             111-46-6
Resorcinol                     108-46-3
2-Amino-2-(hydroxymethyl)-1,3- 77-86-1
propanediol
2,5-Dimethylphenol             95-87-4
Ammonium Phosphate Monobasic   7722-76-1
1,3-Butanediol                 107-88-0
Glycolic Acid                  79-14-1
Sodium Gluconate               527-07-1
Terephthalic Acid              100-21-0
L-Ascorbic Acid Sodium Salt    134-03-2
3-Acetyl-6-methyl-2,4-         520-45-6
pyrandione
Calcium Acetate                62-54-4
Nicotinamide                   98-92-0
1-Hydroxy-2-naphthoic Acid     86-48-6
2-Isopropylphenol              88-69-7
4-Aminosalicylic Acid          65-49-6
Calcium Glycerophosphate       27214-00-2
Erythorbic Acid Sodium Salt    7378-23-6
Gluconic Acid Potassium Salt   299-27-4
Orotic Acid                    65-86-1
p-Anise Alcohol                105-13-5
Potassium Benzoate             582-25-2
Taurine                        107-35-7
Thiamine Nitrate               532-43-4
3,3,5-Trimethyl-1-cyclohexanol 116-02-9
tert-Butylhydroquinone         1948-33-0
Sulfosalicylic acid            97-05-2
Gallic acid                    149-91-7
L-borneol                      464-45-9
Isoborneol                     124-76-5
2,5-Dihydroxybenzoic acid,     490-79-9
Gentisic acid
5-hydroxy-6-methyl-3,4-        65-23-6
pyridinedimethanol
Naphthalene-2-sulfonic acid    120-18-3
Ethanesulfonic acid, 2-        1562-00-1
hydroxy-, monosodium salt
Pamoic acid                    130-85-8
2,4-Dimethylphenol             105-67-9
3,5-Dihydroxyacetophenone      51863-60-6
Eugenol                        97-53-0
n-Butyric Acid                 107-92-6
Hydroquinone                   123-31-9
Propionic Acid                 79-09-4
meta-Phenylenediamine          108-45-2
Oxalic Acid                    144-62-7
n-Hexanoic Acid                142-62-1
2-Furancarboxylic Acid         88-14-2
4′-Nitroacetanilide            104-04-1
D-(−)-Tartaric Acid            147-71-7
p-Acetamidobenzoic Acid        556-08-1
Galactaric acid                526-99-8
D-glucuronate                  1700908
Lactobionic acid               96-82-2
p-Formylacetanilide            122-85-0
2-Mercaptobenzoic acid         147-93-3
Propanoic acid, 2-hydroxy-,    28305-25-1
calcium salt (2:1), (S)-
D(+)-10-Camphorsulfonic acid   3144-16-9
3-Cyclopentylpropionic acid    140-77-2
1R-(−)-Camphorsulfonic acid    35963-20-3
DL-Lysine                      70-54-2
Cinnamic acid                  621-82-9
Triethanolamine                102-71-6
Acetic Acid                    64-19-7
Dichloroacetic Acid            79-43-6
Diethylamine                   109-89-7
Diethylaminoethanol            100-37-8
N-(2-Hydroxyethyl)Morpholine   622-40-2
Octanoic Acid                  124-07-2
isobutyric acid                79-31-2
Anisic Acid                    100-09-4
Betaine                        107-43-7
Enanthoic Acid                 111-14-8
Hippuric Acid                  495-69-2
Tiglic Acid                    80-59-1
Cyclohexanecarboxylic acid     98-89-5
m-Methoxybenzoic acid          586-38-9
D-(+)-Camphoric acid           124-83-4
N-(2-Hydroxyethyl)pyrrolidine  2955-88-6

[0228]

TABLE 4
Crystal data and structure refinement for
Fluoxetine HCl:Benzoic acid (1:1).
Identification code	Fluoxetine HCl:Benzoic acid (1:1)
Empirical formula	C24H25C1F3NO3
Formula weight	467.90
Temperature	100(2) K
Wavelength	0.71073 Å
Crystal system	Monoclinic
Space group	P2(1)/n
Unit cell dimensions	a = 14.806(5) Å	α = 90°.
	b = 13.179(4) Å	β = 97.738(13)°.
	c = 24.417(7) Å	γ = 90°.
Volume	4721(2) Å3
Z	8
Density (calculated)	1.317 Mg/m3
Absorption coefficient	0.210 mm−1
F(000)	1952
Crystal size	0.47 × 0.15 × 0.10 mm3
Theta range for data collection	1.52 to 33.07°.
Index ranges	−22 <= h <= 22, −20 <= k <= 20,
	−37 <= 1 <= 37
Reflections collected	82494
Independent reflections	17030 [R(int) = 0.0751]
Completeness to theta = 33.07°	95.0%
Absorption correction	None
Refinement method	Full-matrix least-squares on F2
Data/restraints/parameters	17030/0/581
Goodness-of-fit on F2	1.053
Final R indices [I > 2sigma(I)]	R1 = 0.0853, wR2 = 0.1933
R indices (all data)	R1 = 0.1330, wR2 = 0.2168
Largest diff. peak and hole	2.571 and −0.689 e · Å−3

[0229]

TABLE 5
Crystal data and structure refinement for Fluoxetine
HCl-succinic acid (2:1).
Identification code	Fluoxetine HCl-succinic acid (2:1)
Empirical formula	C38H42C12F6N2O6
Formula weight	807.64
Temperature	100(2) K
Wavelength	0.71073 Å
Crystal system	Orthorhombic
Space group	Pbcn
Unit cell dimensions	a = 26.620(2) Å	α = 90°.
	b = 7.2147(7) Å	β = 90°.
	c = 20.8315(19) Å	γ = 90°.
Volume	4000.8(6) Å3
Z	4
Density (calculated)	1.341 Mg/m3
Absorption coefficient	0.236 mm−1
F(000)	1680
Crystal size	0.21 × 0.18 × 0.09 mm3
Theta range for data collection	1.53 to 27.50°.
Index ranges	−34 <= h <= 34, −9 <= k <= 9,
	−26 <= 1 <= 27
Reflections collected	37123
Independent reflections	4600 [R(int) = 0.0748]
Completeness to theta = 27.50°	100.0%
Absorption correction	Semi-empirical from equivalents
Max. and min. transmission	1.000 and 0.813837
Refinement method	Full-matrix least-squares on F2
Data/restraints/parameters	4600/0/249
Goodness-of-fit on F2	1.156
Final R indices [I > 2sigma(I)]	R1 = 0.0786, wR2 = 0.1782
R indices (all data)	R1 = 0.0911, wR2 = 0.1852
Largest diff. peak and hole	0.682 and −0.499 e · Å−3

[0230]

TABLE 6
Crystal data and structure refinement for
Nabumetone:2,3-naphthalenediol (1:1).
Identification code	Nabumetone:2,3-naphthalenediol (1:1)
Empirical formula	C25H24O4
Formula weight	388.44
Temperature	100(2) K
Wavelength	1.54178 Å
Crystal system	Monoclinic
Space group	P2(1)/n
Unit cell dimensions	a = 17.1585(7) Å	α = 90°.
	b = 5.5168(3) Å	β = 91.319(3)°.
	c = 20.7083(9) Å	γ = 90°.
Volume	1959.73(16) Å3
Z	4
Density (calculated)	1.317 Mg/m3
Absorption coefficient	0.710 mm−1
F(000)	824
Crystal size	0.21 × 0.08 × 0.025 mm3
Theta range for data collection	3.31 to 66.15°.
Index ranges	−17 <= h <= 19, −6 <= k <= 5,
	−24 <= 1 <= 23
Reflections collected	8803
Independent reflections	3063 [R(int) = 0.0801]
Completeness to theta = 66.15°	89.1%
Absorption correction	None
Refinement method	Full-matrix least-squares on F2
Data/restraints/parameters	3063/2/266
Goodness-of-fit on F2	1.019
Final R indices [I > 2sigma(I)]	R1 = 0.0528, wR2 = 0.1332
R indices (all data)	R1 = 0.1116, wR2 = 0.1692
Largest diff. peak and hole	0.277 and −0.325 e · Å−3

[0231]

TABLE 7
Crystal data and structure refinement for Fluoxetine
HCl-fumaric acid (2:1).
Identification code	a6g41m
Empirical formula	C38H42C12F6N2O6
Formula weight	807.64
Temperature	173(2) K
Wavelength	1.54178 Å
Crystal system	Orthorhombic
Space group	Pbcn
Unit cell dimensions	a = 26.6914(8) Å	α = 90°.
	b = 7.1807(3) Å	β = 90°.
	c = 20.6546(7) Å	β = 90°.
Volume	3958.7 (2) Å3
Z	4
Density (calculated)	1.355 Mg/m3
Absorption coefficient	2.130 mm−1
F(000)	1680
Crystal size	0.20 × 0.14 × 0.08 mm3
Theta range for data collection	3.31 to 58.93°.
Index ranges	−24 <= h <= 29, −7 <= k <= 7,
	−21 <= 1 <= 22
Reflections collected	15698
Independent reflections	2823 [R(int) = 0.1693]
Completeness to theta = 58.93°	99.7%
Absorption correction	None
Refinement method	Full-matrix least-squares on F2
Data/restraints/parameters	2823/0/246
Goodness-of-fit on F2	1.018
Final R indices [I > 2sigma(I)]	R1 = 0.0469, wR2 = 0.0927
R indices (all data)	R1 = 0.0940, wR2 = 0.1197
Largest diff. peak and hole	0.583 and −0.750 e · Å−3

Claims

1. A cocrystal comprising a salt and a neutral guest, wherein the salt comprises an active agent and a counterion, wherein the guest is a carboxylic acid having at least three carbon atoms, and the cocrystal is not a solvate.

2. The cocrystal of claim 1, wherein the guest is a carboxylic acid having at least four carbon atoms.

3. The cocrystal of claim 1, wherein the guest is selected from the group consisting of the guests set forth in Table 1.

4. The cocrystal of claim 1, wherein the guest is selected from the group consisting of the guests set forth in Table 2.

5. The cocrystal of claim 1, wherein the guest is selected from the group consisting of the guests set forth in Table 3.

6. The cocrystal of claim 1, wherein the guest is a carboxylic acid selected from the group consisting of: sorbic acid; L-(+)-tartaric acid; citric acid; benzoic acid; aspirin; lactic acid; fumaric acid; (S)-(+)-arginine; glycine; (S)-(−)-histidine; (S)-(+)-lysine; DL-tartaric acid; (S)-(−)-phenylalanine; (S)-(−)-tyrosine; phenylacetic acid; adipic acid; pyruvic acid; succinic acid; niacin; 4-aminobenzoic acid; o-methylbenzoic acid; valeric acid; maleic acid; 3-methylbutanoic acid; L-glutamic acid; 2,4-dihydroxybenzoic acid; 3-phenylpropionic acid; isocaproic acid; (L)-(+)-isoleucine; L-malic acid; L-2-aminopropionic acid; L-glutamine; L-hydroxyproline L-proline L-serine; L-threonine; L-valine; Phenoxyacetic acid 2-ethylbutyrinc acid; L-leucine; L-asparagine; levulinic acid; (S)-(−)-cysteine; DL-aspartic acid; 4-hydroxybenzoic acid; diphenylacetic acid; glutaric acid; 0-toluic acid; pivalic acid; DL-malic acid; beta-alanine; (S)-(−)-tryptophan; malonic acid; mandelic acid; glycolic acid; terephthalic acid; 1-hydroxy-2-naphthoic acid; 4-aminosalicylic acid; orotic acid; gallic acid; gentisic acid; pamoic acid; n-butyric acid; n-hexanoic acid; 2-furancarboxylic acid; p-acetamidobenzoic acid; galactaric acid; lactobionic acid; 2-mercaptobenzoic acid; 3-cyclopentylpropionic acid; DL-lysine; cinnamic acid; dichloroacetic acid; octanoic acid; isobutyric acid; anisic acid; enanthoic acid; hippuric acid; tiglic acid; cyclohexanecarboxylic acid; m-methoxybenzoic acid; D-(+)-camphoric acid; and cyclohexylacetic acid.

7. The cocrystal of claim 1, wherein the guest is a carboxylic acid selected from the group consisting of: ascorbic acid; glucoheptonic acid; sebacic acid; alginic acid; cyclamic acid; ethane-1,2-disulfonic acid; 2-hydroxyethanesulfonic acid; 2-oxo-glutaric acid; naphthalene-1,5-disulfonic acid; nicotinic acid; pyroglutamic acid; and 4-acetamidobenzoic acid.

8. The cocrystal of claim 1, wherein the guest is selected from the group consisting of benzoic acid, succinic acid, and fumaric acid.

9. The cocrystal of claim 1, wherein the counterion is a halide.

10. The cocrystal of claim 9, wherein the counterion is chloride.

11. The cocrystal of claim 1, wherein the counterion is a positive counterion.

12. The cocrystal of claim 1, wherein the active agent comprises a secondary or tertiary amine, and said amine forms a salt with the counterion.

13. The cocrystal of claim 11, wherein the amine is a tertiary amine.

14. The cocrystal of claim 1, wherein the active agent comprises an active pharmaceutical ingredient.

15. The cocrystal of claim 1, wherein the active agent comprises a nutraceutical.

16. The cocrystal of claim 1, wherein the active agent comprises an agricultural chemical.

17. The cocrystal of claim 1, wherein the active agent comprises a pigment.

18. The cocrystal of claim 1, wherein the active agent comprises a dye.

19. The cocrystal of claim 1, wherein the active agent comprises an explosive.

20. The cocrystal of claim 1, wherein the active agent comprises a polymer additive.

21. The cocrystal of claim 1, wherein the active agent comprises a lubricant additive.

22. The cocrystal of claim 1, wherein the active agent comprises a photographic chemical.

23. A cocrystal comprising a salt and a neutral guest, wherein the salt comprises an active agent and a counterion, wherein the guest is a strong hydrogen bond donor and is selected from the guests set forth in Table 3.

24. The cocrystal of claim 23, wherein the guest is a carboxylic acid having at least four carbon atoms.

25. The cocrystal of claim 23, wherein the guest is selected from the group consisting of the guests set forth in Table 1.

26. The cocrystal of claim 23, wherein the guest is selected from the group consisting of the guests set forth in Table 2.

27. The cocrystal of claim 23, wherein the guest is a carboxylic acid selected from the group consisting of: sorbic acid; L-(+)-tartaric acid; citric acid; benzoic acid; aspirin; lactic acid; fumaric acid; (S)-(+)-arginine; glycine; (S)-(−)-histidine; (S)-(+)-lysine; DL-tartaric acid; (S)-(−)-phenylalanine; (S)-(−)-tyrosine; phenylacetic acid; adipic acid; pyruvic acid; succinic acid; niacin; 4-aminobenzoic acid; o-methylbenzoic acid; valeric acid; maleic acid; 3-methylbutanoic acid; L-glutamic acid; 2,4-dihydroxybenzoic acid; 3-phenylpropionic acid; isocaproic acid; (L)-(+)-isoleucine; L-malic acid; L-2-aminopropionic acid; L-glutamine; L-hydroxyproline L-proline L-serine; L-threonine; L-valine; Phenoxyacetic acid 2-ethylbutyrinc acid; L-leucine; L-asparagine; levulinic acid; (S)-(−)-cysteine; DL-aspartic acid; 4-hydroxybenzoic acid; diphenylacetic acid; glutaric acid; 0-toluic acid; pivalic acid; DL-malic acid; beta-alanine; (S)-(−)-tryptophan; malonic acid; mandelic acid; glycolic acid; terephthalic acid; 1-hydroxy-2-naphthoic acid; 4-aminosalicylic acid; orotic acid; gallic acid; gentisic acid; pamoic acid; n-butyric acid; n-hexanoic acid; 2-furancarboxylic acid; p-acetamidobenzoic acid; galactaric acid; lactobionic acid; 2-mercaptobenzoic acid; 3-cyclopentylpropionic acid; DL-lysine; cinnamic acid; dichloroacetic acid; octanoic acid; isobutyric acid; anisic acid; enanthoic acid; hippuric acid; tiglic acid; cyclohexanecarboxylic acid; m-methoxybenzoic acid; D-(+)-camphoric acid; and cyclohexylacetic acid.

28. The cocrystal of claim 23, wherein the guest is a carboxylic acid selected from the group consisting of: ascorbic acid; glucoheptonic acid; sebacic acid; alginic acid; cyclamic acid; ethane-1,2-disulfonic acid; 2-hydroxyethanesulfonic acid; 2-oxo-glutaric acid; naphthalene-1,5-disulfonic acid; nicotinic acid; pyroglutamic acid; and 4-acetamidobenzoic acid.

29. The cocrystal of claim 23, wherein the guest is selected from the group consisting of benzoic acid, succinic acid, and fumaric acid.

30. The cocrystal of claim 23, wherein the counterion is a halide.

31. The cocrystal of claim 30, wherein the counterion is chloride.

32. The cocrystal of claim 23, wherein the active agent comprises a secondary or tertiary amine, and said amine forms a salt with the counterion.

33. The cocrystal of claim 32, wherein the amine is a tertiary amine.

34. The cocrystal of claim 23, wherein the active agent comprises an active pharmaceutical ingredient.

35. The cocrystal of claim 23, wherein the active agent comprises a nutraceutical.

36. The cocrystal of claim 23, wherein the active agent comprises an agricultural chemical.

37. The cocrystal of claim 23, wherein the active agent comprises a pigment.

38. The cocrystal of claim 23, wherein the active agent comprises a dye.

39. The cocrystal of claim 23, wherein the active agent comprises an explosive.

40. The cocrystal of claim 23, wherein the active agent comprises a polymer additive.

41. The cocrystal of claim 23, wherein the active agent comprises a lubricant additive.

42. The cocrystal of claim 23, wherein the active agent comprises a photographic chemical.

43. A cocrystal comprising a salt and a neutral guest, wherein the salt comprises an active agent and a counterion, and wherein the counterion is not a chloride ion.

44. The cocrystal of claim 43, wherein the salt is formed from the active agent and a mineral acid, and the mineral acid provides the counterion.

45. The cocrystal of claim 43, wherein the salt is formed from the active agent and an inorganic acid, and the inorganic acid provides the counterion.

46. The cocrystal of claim 43, wherein the salt is formed from the active agent and an acid selected from the group consisting of: sulfuric acid; phosphoric acid; hydrobromic and; nitric acid; pyrophosphoric acid; methanesulfonic acid; thiocyanic acid; naphthalene-2-sulfonic acid; 1,5-naphthalenedisulfonic acid; cyclamic acid; p-toluenesulfonic acid; maleic acid; L-aspartic acid; 2-hydroxy-ethanesulfonic acid; glycerophosphoric acid; ethanesulfonic acid; and hydroiodic acid, and the acid provides the counterion.

47. The cocrystal of claim 43, wherein the guest is a phosphate.

48. The cocrystal of claim 43, wherein the guest is a bromide.

49. The cocrystal of claim 43, wherein the guest is a carboxylic acid having at least three carbon atoms.

50. The cocrystal of claim 43, wherein the guest is selected from the group consisting of the guests set forth in Table 1.

51. The cocrystal of claim 43, wherein the guest is selected from the group consisting of the guests set forth in Table 2.

52. The cocrystal of claim 43, wherein the guest is selected from the group consisting of the guests set forth in Table 3.

53. The cocrystal of claim 43, wherein the guest is a carboxylic acid selected from the group consisting of: sorbic acid; L-(+)-tartaric acid; citric acid; benzoic acid; aspirin; lactic acid; fumaric acid; (S)-(+)-arginine; glycine; (S)-(−)-histidine; (S)-(+)-lysine; DL-tartaric acid; (S)-(−)-phenylalanine; (S)-(−)-tyrosine; phenylacetic acid; adipic acid; pyruvic acid; succinic acid; niacin; 4-aminobenzoic acid; o-methylbenzoic acid; valeric acid; maleic acid; 3-methylbutanoic acid; L-glutamic acid; 2,4-dihydroxybenzoic acid; 3-phenylpropionic acid; isocaproic acid; (L)-(+)-isoleucine; L-malic acid; L-2-aminopropionic acid; L-glutamine; L-hydroxyproline L-proline L-serine; L-threonine; L-valine; Phenoxyacetic acid 2-ethylbutyrinc acid; L-leucine; L-asparagine; levulinic acid; (S)-(−)-cysteine; DL-aspartic acid; 4-hydroxybenzoic acid; diphenylacetic acid; glutaric acid; 0-toluic acid; pivalic acid; DL-malic acid; beta-alanine; (S)-(−)-tryptophan; malonic acid; mandelic acid; glycolic acid; terephthalic acid; 1-hydroxy-2-naphthoic acid; 4-aminosalicylic acid; orotic acid; gallic acid; gentisic acid; pamoic acid; n-butyric acid; n-hexanoic acid; 2-furancarboxylic acid; p-acetamidobenzoic acid; galactaric acid; lactobionic acid; 2-mercaptobenzoic acid; 3-cyclopentylpropionic acid; DL-lysine; cinnamic acid; dichloroacetic acid; octanoic acid; isobutyric acid; anisic acid; enanthoic acid; hippuric acid; tiglic acid; cyclohexanecarboxylic acid; m-methoxybenzoic acid; D-(+)-camphoric acid; and cyclohexylacetic acid.

54. The cocrystal of claim 43, wherein the guest is a carboxylic acid selected from the group consisting of: ascorbic acid; glucoheptonic acid; sebacic acid; alginic acid; cyclamic acid; ethane-1,2-disulfonic acid; 2-hydroxyethanesulfonic acid; 2-oxo-glutaric acid; naphthalene-1,5-disulfonic acid; nicotinic acid; pyroglutamic acid; and 4-acetamidobenzoic acid.

55. The cocrystal of claim 43, wherein the guest is selected from the group consisting of benzoic acid, succinic acid, and fumaric acid.

56. A cocrystal comprising a guest and an active agent, wherein the guest is an amine salt which provides a counterion, and the active agent is a carboxylic acid.

57. A method of generating a cocrystal comprising: adding aminor amount of an organic solvent separately to a solid active agent and a guest; melting the active agent to form a solution of the API and the organic solvent; melting the guest to form a solution of the guest and the organic solvent; forming a mixture of the two solutions; and solidifying the resulting mixture to form a cocrystal of the active agent and the guest.

58. A method of preparing a cocrystal of a salt of an active agent and a guest, said method comprising: selecting a salt of an active agent, wherein said salt comprises the active agent and a counterion; theorizing coordination of the counterion by hydrogen bond interactions within said crystal; selecting a guest to coordinate more strongly with the counterion than the coordination within said crystal; preparing a solution, melt or physical mixture comprising the active agent, the counterion, and the guest; subjecting the solution or melt to a crystallization process, or the physical mixture to grinding; forming a cocrystal comprising the salt of the active agent and the guest, wherein the counterion is coordinated with the guest through strong hydrogen bond interactions.

59. The method of claim 58, wherein the counterion is a negative counterion, and the guest is a stronger hydrogen bond donor for at least one coordination site than the active agent.

60. The method of claim 58, wherein the crystal contains at least one C—H hydrogen bond donor with the counterion, and the guest replaces said at least one C—H hydrogen bond donor with at least one O—H hydrogen bond donor.

61. A method of modifying one or more physical properties of a drug formulation, the drug formulation comprising an API, said method comprising: forming cocrystals of the API with a plurality of guests; measuring at least one physical property of said cocrystals; assessing the effect of each guest on said at least one physical property; and preparing the drug formulation from one of said cocrystals having a desired physical property.

62. The method of claim 61, wherein the API is a neutral API.

63. The method of claim 61, wherein the API is provided as a salt.

64. A method of preparing a cocrystalline pharmaceutical composition, said method comprising: obtaining a salt of an active pharmaceutical ingredient, wherein the salt has a negative counterion other than chloride; substituting chloride for the negative counterion in the obtained salt; and cocrystallizing the substituted salt with a suitable guest.

65. A method of preparing a cocrystal from a hydrate, wherein the cocrystal comprises a salt and a neutral guest, and wherein the salt comprises an active agent and a counterion, said method-comprising: providing a hydrate of the salt comprising water of hydration; selecting a guest to coordinate with the counterion; preparing a solution, melt or physical mixture comprising the hydrate and the guest; subjecting the solution or melt to a crystallization process or the physical mixture to grinding; and forming a cocrystal comprising the salt of the active agent and the guest.

66. The method of claim 65, wherein the guest coordinates more strongly with the counterion than the water of hydration coordinates with the counterion.

67. A method of preparing a cocrystal from a solvate, wherein the cocrystal is not a solvate and comprise a salt and a neutral guest, and wherein the salt comprises an active agent and a counterion, said method comprising: providing a solvate of the salt comprising solvent molecules coordinated with the salt; selecting a guest to coordinate more strongly with the counterion than the solvent; preparing a solution, melt or physical mixture comprising the solvate and the guest; subjecting the solution or melt to a crystallization process or the physical mixture to grinding; and forming a cocrystal comprising the salt of the active agent and the guest.

68. The method of claim 67, wherein the guest coordinates more strongly with the counterion than the solvent water of hydration coordinates with the counterion.