Claims
- 1. A pharmaceutical formulation comprising an enteric protectant and a compound of the formula:
- 2. The pharmaceutical formulation of claim 1 wherein E1 is —CO2R5; G1 is NH2 or N3; T1 is NHC(O)CH3; and U1 is —OR4.
- 3. The pharmaceutical formulation of claim 2 wherein E1 is C(O)OCH2CH3; G1 is NH2; T1 is NHC(O)CH3; and U1 is OCH(CH2CH3)2.
- 4. The pharmaceutical formulation of claim 1 comprising a compound of the formula:
- 5. The pharmaceutical formulation of claim 4 wherein the compound further comprises a phosphate salt.
- 6. The pharmaceutical formulation of claim 1 comprising a compound of the formula:
- 7. The pharmaceutical formulation of claim 1 wherein the enteric protectant is selected from cellulose acetate phthalate polymer, methyl acrylate-methacrylic acid copolymer, cellulose acetate succinate polymer, hydroxypropylmethylcellulose phthalate polymer, polyvinyl acetate phthalate polymer, cellulose acetate trimellitate polymer, hydroxypropyl methylcellulose phthalate succinate polymer, methacrylic acid polymer, and methacrylic acid ester polymer.
- 8. The pharmaceutical formulation of claim 1 wherein the formulation is a tablet.
- 9. The pharmaceutical formulation of claim 1 wherein the formulation is a capsule.
- 10. A pharmaceutical formulation comprising a liquid suspension of enteric coated particles of a compound of claim 1.
- 11. A method of inhibiting the activity of neuraminidase comprising the step of contacting a sample suspected of containing neuraminidase with a pharmaceutical formulation of claim 1.
- 12. The method of claim 11 wherein the neuraminidase is influenza neuraminidase in vivo.
- 13. A method for the treatment or prophylaxis of influenza infection in a host comprising administering to the host a therapeutically effective amount of a pharmaceutical formulation of claim 1.
CROSS REFERENCE TO RELATED APPLICATION
[0001] This application is a continuation of U.S. Ser. No. 09/153,964, filed Sep. 16, 1998, which claims the benefit of priority of U.S. Provisional Application Serial No. 60/060,195, filed Sep. 26, 1997.
[0002] This application is also based on U.S. Patent Application Serial No. 08/938,644, filed Sep. 26, 1997, and U.S. Provisional Application Serial No. 60/059,308, filed Sep. 17, 1997.
[0003] This application is also related to U.S. patent application Ser. No. 08/653,034, filed Mar. 24, 1996, which was a continuation-in-part application of U.S. patent application Ser. No. 08/606,624, filed Feb. 26, 1996, which was a continuation-in-part application of U.S. patent application Ser. No. 08/580,567, filed Dec. 29, 1995, which was a continuation-in-part application of U.S. patent application Ser. No. 08/476,946, filed Jun. 6, 1995, which was a continuation-in-part application of U.S. patent application Ser. No. 08/395,245, filed Feb. 27, 1995, all of which are incorporated herein by reference in their entirety. This application is related to U.S. patent application Ser. No. 08/917,640, filed Aug. 22, 1997, which describes methods of making carbocyclic compounds in particular methods of making GS 4104, phosphate salt, and is incorporated by reference in its entirety.
Provisional Applications (2)
|
Number |
Date |
Country |
|
60060195 |
Sep 1997 |
US |
|
60059308 |
Sep 1997 |
US |
Continuations (1)
|
Number |
Date |
Country |
Parent |
09153964 |
Sep 1998 |
US |
Child |
10628773 |
Jul 2003 |
US |