Claims
- 1. A compound of the formula II: ##STR6## wherein R.sub.1 is a lower alkyl having from 1 to 4 carbon atoms.
- 2. A process for preparing a daunomycinone derivative of the formula: ##STR7## wherein R.sub.1 is a lower alkyl group having 1 to 4 carbon atoms, by (a) reacting a compound of formula: ##STR8## with a halide of the general formula R.sub.1 -Y wherein R.sub.1 is a lower alkyl group having 1 to 4 carbon atoms and Y is Cl, Br or I in the presence of a solvent selected from the group consisting of dichloromethane and chloroform, and in the presence of about one equivalent of a base to yield the monoether derivative of the formula: ##STR9## (b) reacting the compound of Formula VI in the presence of a solvent selected from the group consisting of aqueous solvents and alcohols with a base selected from the group consisting of a dilute alkaline hydroxide and an activated basic resin to yield in case of an aqueous medium the compound of the formula: ##STR10## wherein R.sub.1 is as defined above; and in case of an alcoholic medium to yield a bis-phenol derivative of the formula: ##STR11## wherein R.sub.1 is as defined above and R.sub.2 is an alkyl group: (c) hydrolyzing the compound of Formula VII, formed when the solvent is an alcohol, in aqueous trifluoroacetic acid to yield the compound of Formula II.
- 3. A process according to claim 1, wherein the base in step (a) is silver oxide and the aqueous medium in step (b) is aqueous dichloromethane.
- 4. A process according to claim 1, wherein the alcoholic medium in step (b) is alcoholic dichloromethane or methanol.
Priority Claims (1)
Number |
Date |
Country |
Kind |
18775/77 |
May 1977 |
GBX |
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Parent Case Info
This is a division, of application Ser. No. 901,358, filed May 1, 1978, now U.S. Pat. No. 4,191,755.
Government Interests
The invention described herein was made in the course of work under a grant from the United States Department of Health, Education and Welfare.
US Referenced Citations (6)
Divisions (1)
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Number |
Date |
Country |
Parent |
901358 |
May 1978 |
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