Claims
- 1. A 2-fluoroalkylated 4-acylresorcinol ether of the formula ##STR48## in which R.sub.1 is lower alkyl having not more than 4 C atoms, R.sub.2 is .omega.-fluoro-,.omega., .omega.-difluoro- or .omega.,.omega.,.omega.-trifluoro-lower alkyl having not more than 4 C atoms, R.sub.3 is hydrogen, R.sub.4 is hydrogen, lower alkyl, trifluoromethyl or halogen with an atomic number of not more than 35, R.sub.5 is 5-tetrazolyl carbonylamino, R.sub.6 is hydrogen, lower alkyl having not more than 4 C atoms, halogen with an atomic number of not more than 35, trifluoromethyl, lower alkoxycarbonyl having not more than 5 C atoms, cyano or carbamyl, R.sub.7 is hydrogen, lower alkyl having not more than 4 C atoms, halogen with an atomic number of not more than 35, carbamyl or cyano and alk is straight chain, terminally bonded lower alkylene having 2 to not more than 5 C atoms, or hydroxy-lower alkylene having 3 to not more than 7 C atoms, in which the hydroxyl group is bonded in a position higher than the .alpha.-position and lower than the .omega.-position, or a pharmaceutically acceptable salt thereof.
- 2. A compound as claimed in claim 1, in which R.sub.1 is lower alkyl having not more than 4 C atoms, R.sub.2 is .omega., .omega., .omega.-trifluoro-lower alkyl having not more than 3 C atoms, R.sub.3 is hydrogen and R.sub.5 is 5-tetrazolylcarbonylamino, R.sub.4 is lower alkyl having not more than 4C atoms, R.sub.6 is halogen with an atomic number of not more than 35, or cyano, R.sub.7 is hydrogen, and alk is straight-chain, terminally bonded lower alkylene having 2 to not more than 5 C atoms, or hydroxy-lower alkylene having 3 to not more than 7 C atoms, in which the hydroxyl group is bonded in a position higher than the .alpha.-position and lower than the .omega.-position, or a pharmceutically acceptable salt thereof.
- 3. A compound as claimed in claim 1, in which R.sub.1 is lower alkyl having not more than 4 C atoms, R.sub.2 is .omega.-fluoro-, .omega.,.omega.-difluoro- or .omega.,.omega.,.omega.-trifluoro-lower alkyl having not more than 3 C atoms, R.sub.3 and R.sub.7 are hydrogen, R.sub.4 is hydrogen or lower alkyl having not more than 4 C atoms, R.sub.6 is hydrogen, cyano or halogen with an atomic number of not more than 35, R.sub.5 is 5-tetrazolylcarbonylamino and alk is straight-chain, terminally bonded lower alkylene having 2 to not more than 5 C atoms, or hydroxy-lower alkylene having 3 to not more than 7 C atoms, in which the hydroxyl group is bonded in a position higher than the .alpha.-position and lower than the .omega.-position, or a pharmaceutically acceptable salt thereof.
- 4. A compound as claimed in claim 1 being N-{{3-{3-[4-Acetyl-3-hydroxy-2-(3,3,3-trifluoropropyl)-phenoxy]-propoxy}-4-chloro-6-methyl-phenyl}}-1H-tetrazole-5-carboxamide or a pharmaceutically acceptable salt thereof.
- 5. A compound as claimed in claim 1 being N-{{-3-{3-[4-Acetyl-3-hydroxy-2-(3,3,3-trifluoropropoyl)-phenoxy]-propoxy}-4-bromo-6-methyl-phenyl}}-1H-tetrazole-5-carboxamide or a pharmaceutically acceptable salt thereof.
- 6. A compound as claimed in claim 1 being N-{{3-{3-[4-acetyl-3-hydroxy-2-(3,3,3-trifluoropropyl)-phenoxy]-2-hydroxy-propoxy}-4-bromo 6-methyl-phenyl}}-1H-tetrazole-5-carboxamide or a pharmaceutically acceptable salt thereof.
- 7. A compound as claimed in claim 1 being N-{{3-{3-[4-acetyl-3-hydroxy-2-(3,3,3-trifluoropropyl)-phenoxy]-2-hydroxy-propoxy}-4-chloro-6-methyl-phenyl}}-1H-tetrazole-5-carboxamide or a pharmaceutically acceptable salt thereof.
- 8. A compound as claimed in claim 1 being N-{{3-{3-[4-acetyl-3-hydroxy-2-(3,3,3-trifluoropropyl)-phenoxy]-2-hydroxy-propoxy}-4-cyano-6-methyl-phenyl}}-1H-tetrazole-5-carboxamide or a pharmaceutically acceptable salt thereof.
- 9. A compound as claimed in claim 1 being N-{{3-{3-[4-acetyl-3-hydroxy-2-(3,3,3-trifluoropropyl)-phenoxy]-propoxy}-phenyl}}-1H-tetrazole-5-carboxamide or a pharmaceutically acceptable salt thereof.
- 10. A compound as claimed in claim 1 being N-{{3-{3-[4-acetyl-3-hydroxy-2-(3,3,3-trifluoropropyl)-phenoxy]-propoxy}-6-methyl-phenyl)}-1H-tetrazole-5-carboxamide or a pharmaceutically acceptable salt thereof.
- 11. A pharmaceutical composition containing a therapeutically effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt thereof, in admixture to customary pharmaceutical adjuncts and/or carriers.
- 12. Method of treatment of allergies and/or inflammations characterised in that a therapeutically effective amount of a compound claimed in claim 1 or a pharmaceutically acceptable salt thereof is administered.
Priority Claims (1)
Number |
Date |
Country |
Kind |
4016/85 |
Sep 1985 |
CHX |
|
Parent Case Info
This is a continuation of Ser. No. 297,724 filed Jan. 17, 1989, abandoned, which is a division of application Ser. No. 003,156 filed on Jan. 14, 1987, U.S. Pat. No. 4,820,726, which is a continuation-in-part application of our co-pending application Ser. No. 801,012 filed Nov. 22, 1985, abandoned.
US Referenced Citations (12)
Foreign Referenced Citations (6)
Number |
Date |
Country |
28063 |
May 1981 |
EPX |
123541 |
Oct 1984 |
EPX |
132366 |
Jan 1985 |
EPX |
132367 |
Jan 1985 |
EPX |
147973 |
Jul 1985 |
EPX |
2151227 |
Jul 1985 |
GBX |
Non-Patent Literature Citations (3)
Entry |
Chem. Abstract, 88, 37429q (1978). |
Chem. Abstract, 93, 26100c (1980). |
Chem. Abstract 89, 129265g (1978). |
Divisions (1)
|
Number |
Date |
Country |
Parent |
3156 |
Jan 1987 |
|
Continuations (1)
|
Number |
Date |
Country |
Parent |
297724 |
Jan 1989 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
801012 |
Nov 1985 |
|