Claims
- 1. A process for the production of a salt of a compound of the formula: ##STR8## wherein X is oxygen, and wherein R is a radical selected from the group consisting of lower alkyl, cyclopentyl and cyclohexyl, which comprises reacting 2-methylenequinuclidin-3-one with the corresponding radical -substituted diloweralkylmalonate in the presence of sodium alkoxide to give the corresponding 3-oxoquinuclidin-2-yl) malonate, reducing the latter with sodium borohydride to the corresponding (3-hydroxyquinuclidin-2-yl malonate, and treating the latter with a concentrated mineral acid to obtain the desired product, a 4-radical-6-oxa-1-azatricyclo (4.2.2.0.sup.2,7) dodecan-5-one salt.
- 2. A process for the production of a salt of a compound of the formula: ##STR9## wherein X is oxygen and R is a radical selected from the group consisting of thienyl, phenyl, methylphenyl, methoxyphenyl, chlorophenyl, trifluromethylphenyl, aminophenyl, di-loweralkylaminophenyl and benzyl, which comprises reacting 2-methylene quinuclidin-3-one with the corresponding radical-substituted diloweralkylacetate in the presence of sodium alkoxide to give the corresponding (3-oxoquinuclidin-2-yl) acetate, reducing the latter with sodium borohydride to the corresponding (3-hydroxyquinuclidin-2-yl) acetate, and treating the latter with a concentrated mineral acid to obtain the desired product, a 4-radical-6-oxa-1-azatricyclo(4.2.2.0.sup.2.7) dodecan-5-one salt.
Priority Claims (1)
Number |
Date |
Country |
Kind |
48453 |
Nov 1975 |
ILX |
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Parent Case Info
This is a division, of application Ser. No. 852,402, filed Nov. 17, 1977, which in turn is a division of Ser. No. 655,650, filed Feb. 6, 1976, now U.S. Pat. No. 4,083,985, issued Apr. 11, 1978.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3857837 |
Gutzwiller et al. |
Dec 1974 |
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Divisions (2)
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Number |
Date |
Country |
Parent |
852402 |
Nov 1977 |
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Parent |
655650 |
Feb 1976 |
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