NOVEL INTRACELLULAR TARGETS FOR ANTIFUNGAL AGENTS

Information

• Research Project
• 2522117

• ApplicationId

  2522117

• Core Project Number

  R43AI041315

• Full Project Number

  1R43AI041315-01A1

• Serial Number

  41315

• FOA Number

• Sub Project Id

• Project Start Date

  7/15/1998 - 27 years ago

• Project End Date

  7/14/1999 - 26 years ago

• Program Officer Name

• Budget Start Date

  7/15/1998 - 27 years ago

• Budget End Date

  7/14/1999 - 26 years ago

• Fiscal Year

  1998

• Support Year

  1

• Suffix

  A1

• Award Notice Date

  7/9/1998 - 27 years ago

Organizations

• SYMBIOTECH, INC.

The aim of this Phase I SBIR study is to identify intracellular binding proteins for novel antifungal agents. Previous studies indicated that our novel antifungal agents bind to specific intracellular sites. We propose to purify the binding proteins by affinity chromatography. Antibodies will be raised against the purified proteins and immunohistochemical studies will be performed on fungi, bacteria and human cells. The binding proteins will be partially sequenced and the sequences will be compared to known proteins in gene data bases. The proteins will also be cloned. The purified binding proteins will serve as novel molecular targets for screening molecular libraries and in analog development. PROPOSED COMMERCIAL APPLICATIONS: Investigations in this study may lead to novel drugs for the treatment of topical and/or systemic fungal infections.

IC Name

• Activity

  R43

• Administering IC

  AI

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  856

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  ZRG5

• Study Section Name

• Organization Name

  SYMBIOTECH, INC.

• Organization Department

• Organization DUNS

• Organization City

  WALLINGFORD

• Organization State

  CT

• Organization Country

  UNITED STATES

• Organization Zip Code

  06492

• Organization District

  UNITED STATES