NOVEL POLYMORPHIC MARKERS FOR GENETIC ANALYSES

Information

  • Research Project
  • 2445549
  • ApplicationId
    2445549
  • Core Project Number
    R44MH052940
  • Full Project Number
    5R44MH052940-03
  • Serial Number
    52940
  • FOA Number
  • Sub Project Id
  • Project Start Date
    9/30/1994 - 29 years ago
  • Project End Date
    10/31/1998 - 25 years ago
  • Program Officer Name
  • Budget Start Date
    7/1/1997 - 26 years ago
  • Budget End Date
    10/31/1998 - 25 years ago
  • Fiscal Year
    1997
  • Support Year
    3
  • Suffix
  • Award Notice Date
    5/16/1997 - 27 years ago
Organizations

NOVEL POLYMORPHIC MARKERS FOR GENETIC ANALYSES

The continuing development and use of polymorphic DNA markers has become an increasingly effective means of identifying genetic traits or individuals. Improvements in speed and sensitivity of this technology have produced growing commercial opportunities for applications in linkage analysis, disease detection, forensic sciences, and paternity determination during the past decade. However, current methods are still relatively timeconsuming and often work best in conjunction with the use of radioactivity. Our Phase I application proposed the development of a new and superior class of amplifiable polymorphic markers based on a proprietary concept. In meeting or exceeding all of the goals of our Phase I proposal, we demonstrated a reasonable frequency and degree of polymorphism for these new markers, and that they can be detected more quickly, cheaply, and simply in non-isotopic formats than previously developed markers. The Phase II application proposes the isolation of a large number of these markers for general use in linkage mapping and disease detection. The most polymorphic of the markers will be tested in several different racial/ethnic populations to develop highly discriminating multiplex sets for applications in forensic sciences, paternity determination, monitoring of bone marrow transplants, and tissue culture cell identification. PROPOSED COMMERCIAL APPLICATION: The superior ease of use, cheaper cost, and quick handling of ITR markers will allow their rapid commercialization as multiplex systems for forensic analyses, generation of convicted offender databases, tissue culture identification, monitoring of bone marrow transplantation, and paternity determinations. Fifty to 200 new markers of this superior quality will also be available for linkage studies.

IC Name
NATIONAL INSTITUTE OF MENTAL HEALTH
  • Activity
    R44
  • Administering IC
    MH
  • Application Type
    5
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    242
  • Ed Inst. Type
  • Funding ICs
  • Funding Mechanism
  • Study Section
    ZRG7
  • Study Section Name
  • Organization Name
    PROMEGA CORPORATION
  • Organization Department
  • Organization DUNS
  • Organization City
    MADISON
  • Organization State
    WI
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    537115399
  • Organization District
    UNITED STATES