Claims
- 1. A process for the preparation of 4-aryl-piperidines of structure (1)
- 2. A process for the preparation of 4-aryl-piperidines of structure (1)
- 3. A process according to claim 1, in which the reduction is carried out by catalytic hydrogenation at atmospheric or above atmospheric pressure or using hydride reagents.
- 4. A process according to claim 1, in which a compound of structure (1) in which Z is alkyl, aralkyl or aryl is prepared by selective reduction of the ester group in a compound of structure (2a) or (2b) in which Z is alkyl, aralkyl or aryl.
- 5. A process for the preparation of 4-aryl-piperidines of structure (1)
- 6. A process according to claim 1, in which the reduction is accomplished by catalytic hydrogenation at atmospheric or above atmospheric pressure or using hydride reagents.
- 7. A compound of structure (2a) or (2b)
- 8. A compound of structure (4a) or (4b)
- 9. A compound of structure (4c) or (4d)
- 10. A compound of structure (1)
- 11. A compound according to claim 9, in the form of a hydrochloride salt.
- 12. A method of treating the Disorders which comprises administering an effective or prophylactic amount of a compound as claimed in claim 9 to a person suffering from one or more of the Disorders.
Priority Claims (2)
Number |
Date |
Country |
Kind |
9711095.1 |
May 1997 |
GB |
|
9714875.3 |
Jul 1997 |
GB |
|
Parent Case Info
[0001] The present invention relates to a new process for preparing pharmaceutically active compounds and intermediates therefor.
[0002] Pharmaceutical products with antidepressant and anti-Parkinson properties are described in U.S. Pat. No. 3,912,743 and U.S. Pat. No. 4,007,196. An especially important compound among those disclosed is paroxetine, the (−) transisomer of 4-(4′-fluorophenyl)-3-(3′,4-methylenedioxy-phenoxymethyl)-piperidine. This compound is used in therapy as the hydrochloride salt to treat inter alia depression, obsessive compulsive disorder (OCD) and panic.
Continuations (2)
|
Number |
Date |
Country |
Parent |
09688423 |
Oct 2000 |
US |
Child |
10138553 |
May 2002 |
US |
Parent |
09087632 |
May 1998 |
US |
Child |
09688423 |
Oct 2000 |
US |