NOVEL PRODRUGS FOR TREATMENT OF OPPORTUNISTIC INFECTIONS

Information

• Research Project
• 6373568

• ApplicationId

  6373568

• Core Project Number

  R44AI040518

• Full Project Number

  5R44AI040518-03

• Serial Number

  40518

• FOA Number

• Sub Project Id

• Project Start Date

  9/30/1996 - 27 years ago

• Project End Date

  8/31/2002 - 22 years ago

• Program Officer Name

  LAMBROS, CHRIS

• Budget Start Date

  9/1/2001 - 23 years ago

• Budget End Date

  8/31/2002 - 22 years ago

• Fiscal Year

  2001

• Support Year

  3

• Suffix

• Award Notice Date

  8/24/2001 - 23 years ago

Organizations

• Immtech International Inc.

The long-range goal is to develop new drugs to treat important AIDS-related opportunistic infections and tropical parasitic diseases. STTR Phase I studies confirmed the hypothesis that diamidoxime prodrugs are readily absorbed after oral administration, then metabolized to active diamidines, with excellent antimicrobial activity and reduced host toxicity. Phase I research identified a lead candidate prodrug, DR 289 that is highly active orally in rodent models of P. carinii and African trypanosomiasis, with markedly reduced toxicity compared to pentamidine. The objective in Phase II is to synthesize sufficient quantities of DB289 to perform formal preclinical toxicity and further pharmacological studies required to support IND filing for Phase I clinical trials. The immediate goal is to apply for FDA approval to begin human clinical trials as an orally active agent to treat P. carinii pneumonia. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

IC Name

• Activity

  R44

• Administering IC

  AI

• Application Type

  5

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

  143942

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  856

• Ed Inst. Type

• Funding ICs

  NIAID:143942\

• Funding Mechanism

• Study Section

  ZRG1

• Study Section Name

  Special Emphasis Panel

• Organization Name

  IMMTECH INTERNATIONAL, INC.

• Organization Department

• Organization DUNS

• Organization City

  VERNON HILLS

• Organization State

  IL

• Organization Country

  UNITED STATES

• Organization Zip Code

  600611860

• Organization District

  UNITED STATES