Claims
- 1. A compound of formula (I)
- 2. A compound according to claim 1 wherein
R1 is selected from the group consisting of alkyl, haloalkyl and halogen; and R4, R5, R6 and R7 are each hydrogen.
- 3. A compound according to claim 1 wherein
n is 0; A is S(O)2; and D is CR2R3.
- 4. A compound according to claim 1 wherein
m is 1; n is 0; A is S(O)2; D is CR2R3; Z is O; and R2, R3, R4, R5, R6 and R7 are each hydrogen.
- 5. A compound according to claim 4 that is selected from the group consisting of
9-(4-fluoro-3-[125I]iodophenyl)-2,3,5,9-tetrahydro-4H-pyrano[3,4-b]thieno[2,3-e]pyridin-8(7H)-one 1,1-dioxide; (R) 9-(4-fluoro-3-[125I]iodophenyl)-2,3,5,9-tetrahydro-4H-pyrano[3,4-b]thieno[2,3-e]pyridin-8(7H)-one 1,1-dioxide; and (S) 9-(4-fluoro-3-[125I]iodophenyl)-2,3,5,9-tetrahydro-4H-pyrano[3,4-b]thieno[2,3-e]pyridin-8(7H)-one 1,1-dioxide.
- 6. A compound according to claim 1 wherein
n is 0; A is C(O); and D is CR2R3.
- 7. A compound according to claim 1 wherein
n is 0; A is C(O); and D is O.
- 8. A compound according to claim 1 wherein
m is 1; n is 0; A is C(O); D is O; Z is O; and R4, R5, R6 and R7 are each hydrogen.
- 9. A compound according to claim 8 selected from the group consisting of
9-(3-[125I]iodo-4-methylphenyl)-5,9-dihydro-3H-furo[3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione; (+) 9-(3-[125I]iodo-4-methylphenyl)-5,9-dihydro-3H-furo[3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione; (−) 9-(3-[125I]iodo-4-methylphenyl)-5,9-dihydro-3H-furo[3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione; 9-(4-fluoro-3-[125I]iodophenyl)-5,9-dihydro-3H-furo[3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione; (9S) 9-(4-fluoro-3-[125I]iodophenyl)-5,9-dihydro-3H-furo[3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione; and (9R) 9-(4-fluoro-3-[125I]iodophenyl)-5,9-dihydro-3H-furo[3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione.
- 10. A compound according to claim 1 wherein
n is 0; A is C(O); D is O; R4, R5 and R6 are each hydrogen; and R7 is alkyl.
- 11. A compound according to claim 1 wherein
m is 1; n is 0; A is C(O); D is O; Z is O; R4, R5 and R6 are each hydrogen; and R7 is alkyl.
- 12. A compound according to claim 11 selected from the group consisting of
(trans) 9-(4-fluoro-3-[125I]iodophenyl)-3-methyl-5,9-dihydro-3H-furo[3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione; (cis) 9-(4-fluoro-3-[125I]iodophenyl)-3-methyl-5,9-dihydro-3H-furo[3,4-b]pyrano [4,3-e]pyridine-1,8(4H,7H)-dione; and (3R,9S)-9-(4-fluoro-3-[125I]iodophenyl)-3-methyl-5,9-dihydro-3H-furo[3,4-e]pyrano [4,3-e]pyridine-1,8(4H,7H)-dione.
- 13. A compound according to claim 11 that is (3S,9R)-9-(4-fluoro-3-[125I]iodophenyl)-3-methyl-5,9-dihydro-3H-furo[3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione.
- 14. A compound according to claim 1 wherein
m is 1; n is 1; A is C(O); and D is O.
- 15. A compound according to claim 1 wherein
m is 1; n is 1; A is C(O); D is O; and R4, R5, R6 and R7 are each hydrogen.
- 16. A compound according to claim 1 wherein
m is 1; n is 1; A is C(O); D is O; Z is O; and R4, R5, R6 and R7 are each hydrogen.
- 17. A compound according to claim 16 selected from the group consisting of
5-(4-fluoro-3-[125I]iodophenyl)-5,10-dihydro-1H,3H-dipyrano[3,4-b:4,3-e]pyridine-4,6(7H,9H)-dione; 5-(3-[125I]iodo-4-methylphenyl)-5,10-dihydro-1H,3H-dipyrano[3,4-b:4,3-e]pyridine-4,6(7H,9H)-dione; and 5-[3-[125I]iodo-4-(trifluoromethyl)phenyl]-5,10-dihydro-1H,3H-dipyrano[3,4-b:4,3-e]pyridine-4,6(7H,9H)-dione.
Parent Case Info
[0001] This application claims priority from U.S. Provisional Application Serial No. 60/308,703, filed Jul. 30, 2001, incorporated herein by reference.
Provisional Applications (1)
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Number |
Date |
Country |
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60308703 |
Jul 2001 |
US |