Claims
- 1. A compound of the formula (I)
- 2. A compound as claimed in claim 1, where R1 and R2 independently of one another are H or C1-C6-alkyl.
- 3. A compound as claimed in claim 2 wherein at least one of R1 and R2 is H.
- 4. A compound as claimed in claim 3 wherein R1 and R2 are H.
- 5. A compound as claimed in claim 1, where R3 is OH or —O—(C1-C6-alkyl).
- 6. A compound as claimed in claim 5 where R3 is OH.
- 7. A compound as claimed in claim 1, where R4 is C1-C6-alkyl or —(C1-C6-alkyl)-(C5-C14-aryl).
- 8. A compound as claimed in claim 7 where R4 is benzyl, 2-butyl or 1-(2-methylpropyl)
- 9. A compound as claimed in claim 1, wherein the compound of the formula (I) has the following formula (II)
- 10. A compound as claimed in one of claim 1, wherein the compound of the formula (I) has the following formula (III)
- 11. A compound as claimed in claim 1, wherein the compound of the formula (I) has the following formula (IV)
- 12. A process for the preparation of a compound of the formula (I) as claimed in claim 1, which comprises fermenting the strain Stachybotris atra ST002348, DSM 14952, or one of its variants or mutants under suitable conditions in a culture medium until one or more of the compounds of the formula (I) accumulate in the culture medium and then isolating it from the culture medium and optionally converting it into a physiologically tolerable salt.
- 13. A method for the treatment and/or prophylaxis of coronary heart disease, acute myocardial infarct, unstable angina pectoris, venous thrombosis and venous thromboembolisms, arterial thrombosis, arteriosclerosis, insulin resistance and macrovascular injuries in type II diabetes mellitus patients, hypoxia, septic shock, pneumonia and pulmonary fibrosis, and cancers, in particular breast cancer, intestinal cancer, gastric cancer, hepatic cancer, brain tumors, ovarian tumors, esophageal cancer, renal cancer, muscle cell carcinoma, said method comprising administering to a human or veterinary subject a pharmaceutically effective amount of a compound of the formula (I) or of a physiologically tolerable salt thereof as claimed in claim 1.
- 14. The method as claimed in claim 13 for the treatment of and/or as a prophylaxis for thromboembolic diseases by the inhibition of clotting.
- 15. A pharmaceutical composition comprising a pharmaceutically effective amount of at least one compound of the formula (I) or of a physiologically tolerable salt thereof as claimed in claim 1, alone or as a mixture with one or more of the customary pharmacologically suitable vehicles or excipients.
- 16. The microorganism Stachybotris atra ST002348, DSM 14952.
Priority Claims (1)
Number |
Date |
Country |
Kind |
DE10258650.0 |
Dec 2002 |
DE |
|
Parent Case Info
[0001] This application claims the benefit of U.S. Provisional Application No. 60/465,999, filed Apr. 28, 2003, and incorporated herein by reference.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60465999 |
Apr 2003 |
US |