Claims
- 1. An .alpha.-adrenolytic composition comprising an effective amount of a compound selected from the group consisting of thiazolcarboxamides of the formula ##EQU6## wherein R is selected from the group consisting of alkyl of 1 to 6 carbon atoms and phenyl, R.sub.1 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, n is a whole number from 2 to 5 and X and X.sub.1 are individually selected from the group consisting of hydrogen, halogen, trifluoromethyl and alkyl, alkoxy and alkylthio of 1 to 4 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts and a pharmaceutical carrier.
- 2. A method of treating hypertension in warm-blooded animals comprising administering a hypotensively effective amount of a compound selected from the group consisting of thaizolcarboxamides of the formula ##EQU7## wherein R is selected from the group consisting of alkyl of 1 to 6 carbon atoms and phenyl, R.sub.1 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, n is a whole number from 2 to 5 and X and X.sub.1 are individually selected from the group consisting of hydrogen, halogen, trifluoromethyl and alkyl, alkoxy and alkylthio of 1 to 4 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts.
- 3. The method of claim 2 wherein X.sub.1 is hydrogen and X is o-methoxy.
- 4. The method of claim 3 wherein R is selected from the group consisting of ethyl, propyl and phenyl and R.sub.1 is selected from the group consisting of hydrogen and methyl and n is 2 or 4.
- 5. The method of claim 2 wherein the compound is selected from the group consisting of N-.beta.-[4'-(o-methoxyphenyl)-1'-piperazinyl]-ethyl-2-n-propylthiazol-5-carboxamide and its non-toxic, pharmaceutically acceptable acid addition salts.
- 6. The method of claim 2 wherein the compound is selected from the group consisting of N-.beta.-[4'-(o-methoxyphenyl)-1'-piperazinyl]-ethyl-2-ethylthiazole-5-carboxamide and its non-toxic, pharmaceutically acceptable acid addition salts.
- 7. The method of claim 2 wherein the compound is selected from the group consisting of N-.beta.-[4'-(o-methoxyphenyl)-1'-piperazinyl]-ethyl-2-phenylthiazole-5-carboxamide and its non-toxic, pharmaceutically acceptable acid addition salts.
- 8. The method of claim 2 wherein the compound is selected from the group consisting of N-methyl-N-.beta.-[4'-(o-methoxyphenyl)-1'-piperazinyl]-ethyl-2-n-propylthiazol-5-carboxamide and its non-toxic, pharmaceutically acceptable acid addition salts.
- 9. The method of claim 2 wherein the compound is selected from the group consisting of N-.delta.-[4'-(o-methoxyphenyl)-1'-piperazinyl]-butyl-2-n-propylthiazol-5-carboxamide and its non-toxic, pharmaceutically acceptable acid addition salts.
Priority Claims (1)
Number |
Date |
Country |
Kind |
72.10010 |
Mar 1972 |
FR |
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PRIOR APPLICATION
This application is a division of our copending, commonly assigned U.S. patent application Ser. No. 340,289 filed Mar. 12, 1973, now U.S. Pat. No. 3,872,124.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3530131 |
de Stevens |
Sep 1970 |
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3658822 |
Fauran et al. |
Apr 1972 |
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Divisions (1)
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Number |
Date |
Country |
Parent |
340289 |
Mar 1973 |
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