Novel therapeutic targets in cancer

Abstract
The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.
Description
TECHNICAL FIELD OF THE INVENTION

This invention relates generally to the field of cancer-associated genes. Specifically, it relates to novel sequences for use in diagnosis and treatment of cancer and tumors, as well as the use of the novel compositions in screening methods. The present invention provides methods of using cancer associated polynucleotides, their corresponding gene products and antibodies specific for the gene products in the detection, diagnosis, prevention and/or treatment of associated cancers.


BACKGROUND OF THE INVENTION

Oncogenes are genes that can cause cancer. Carcinogenesis can occur by a wide variety of mechanisms, including infection of cells by viruses containing oncogenes, activation of protooncogenes in the host genome, and mutations of protooncogenes and tumor suppressor genes. Carcinogenesis is fundamentally driven by somatic cell evolution (i.e. mutation and natural selection of variants with progressive loss of growth control). The genes that serve as targets for these somatic mutations are classified as either protooncogenes or tumor suppressor genes, depending on whether their mutant phenotypes are dominant or recessive, respectively.


There are a number of viruses known to be involved in human cancer as well as in animal cancer. Of particular interest here are viruses that do not contain oncogenes themselves; these are slow-transforming retroviruses. They induce tumors by integrating into the host genome and affecting neighboring protooncogenes in a variety of ways. Provirus insertion mutation is a normal consequence of the retroviral life cycle. In infected cells, a DNA copy of the retrovirus genome (called a provirus) is integrated into the host genome. A newly integrated provirus can affect gene expression in cis at or near the integration site by one of two mechanisms. Type I insertion mutations up-regulate transcription of proximal genes as a consequence of regulatory sequences (enhancers and/or promoters) within the proviral long terminal repeats (LTRs). Type II insertion mutations cause truncation of coding regions due to either integration directly within an open reading frame or integration within an intron flanked on both sides by coding sequences. The analysis of sequences at or near the insertion sites has led to the identification of a number of new protooncogenes.


With respect to lymphoma and leukemia, retroviruses such as AKV murine leukemia virus (MLV) or SL3-3 MLV, are potent inducers of tumors when inoculated into susceptible newborn mice, or when carried in the germline. A number of sequences have been identified as relevant in the induction of lymphoma and leukemia by analyzing the insertion sites; see Sorensen et al., J. of Virology 74:2161 (2000); Hansen et al., Genome Res. 10(2):237-43 (2000); Sorensen et al., J. Virology 70:4063 (1996); Sorensen et al., J. Virology 67:7118 (1993); Joosten et al., Virology 268:308 (2000); and Li et al., Nature Genetics 23:348 (1999); all of which are expressly incorporated by reference herein. With respect to cancers, especially breast cancer, prostate cancer and cancers with epithelial origin, the mammalian retrovirus, mouse mammary tumor virus (MMTV) is a potent inducer of tumors when inoculated into susceptible newborn mice, or when carried in the germ line. Mammary Tumors in the Mouse, edited by 3. Hilgers and M. Sluyser; Elsevier/North-Holland Biomedical Press; New York, N.Y.


The pattern of gene expression in a particular living cell is characteristic of its current state. Nearly all differences in the state or type of a cell are reflected in the differences in RNA levels of one or more genes. Comparing expression patterns of uncharacterized genes may provide clues to their function. High throughput analysis of expression of hundreds or thousands of genes can help in (a) identification of complex genetic diseases, (b) analysis of differential gene expression over time, between tissues and disease states, and (c) drug discovery and toxicology studies. Increase or decrease in the levels of expression of certain genes correlate with cancer biology. For example, oncogenes are positive regulators of tumorigenesis, while tumor suppressor genes are negative regulators of tumorigenesis. (Marshall, Cell, 64: 313-326 (1991); Weinberg, Science, 254: 1138-1146 (1991)).


Accordingly, it is an object of the invention to provide polynucleotide and polypeptide sequences involved in cancer and, in particular, in oncogenesis.


Immunotherapy, or the use of antibodies for therapeutic purposes has been used in recent years to treat cancer. Passive immunotherapy involves the use of monoclonal antibodies in cancer treatments. See for example, Cancer: Principles and Practice of Oncology, 6th Edition (2001) Chapt. 20 pp. 495-508. Inherent therapeutic biological activity of these antibodies include direct inhibition of tumor cell growth or survival, and the ability to recruit the natural cell killing activity of the body's immune system. These agents are administered alone or in conjunction with radiation or chemotherapeutic agents. Rituxan® and Herceptin®, approved for treatment of lymphoma and breast cancer, respectively, are two examples of such therapeutics. Alternatively, antibodies are used to make antibody conjugates where the antibody is linked to a toxic agent and directs that agent to the tumor by specifically binding to the tumor. Mylotarg® is an example of an approved antibody conjugate used for the treatment of leukemia.


Accordingly, it is another object of this invention to provide antigens (cancer-associated polypeptides) associated with a variety of cancers as targets for diagnostic and/or therapeutic antibodies. These antigens are also useful for drug discovery (e.g., small molecules) and for further characterization of cellular regulation, growth, and differentiation.


SUMMARY OF THE INVENTION

In accordance with the objects outlined above, the present invention provides methods for screening for compositions that modulate cancer, especially lymphoma and leukemia. The present invention also provides methods for screening for compositions which modulate carcinomas, especially mammary adenocarcinomas. Also provided herein are methods of inhibiting proliferation of a cell, preferably a lymphoma cell or a breast cancer cell. Methods of treatment of cancer, including diagnosis, are also provided herein.


In one aspect, a method of screening drug candidates comprises providing a cell that expresses a cancer-associated (CA) gene or fragments thereof. Preferred embodiments of CA genes are genes that are differentially expressed in cancer cells, preferably lymphatic, breast, prostate or epithelial cells, compared to other cells. Preferred embodiments of CA genes used in the methods herein include, but are not limited to the nucleic acids selected from Tables 1-7 (human genomic sequences of SEQ ID NOS: 6, 16, 26, 40, 52, 60 and 66, and sequences of SEQ ID NOS: 7, 9, 17, 19, 21, 27, 29, 41, 43, 45, 47, 53, 61, 67, 69, 71 and 73 corresponding to the human mRNAs generated therefrom). The methods further include adding a drug candidate to the cell and determining the effect of the drug candidate on the expression of the CA gene.


In one embodiment, the method of screening drug candidates includes comparing the level of expression in the absence of the drug candidate to the level of expression in the presence of the drug candidate.


Also provided herein is a method of screening for a bioactive agent capable of binding to a CA protein (CAP), the method comprising combining the CAP and a candidate bioactive agent, and determining the binding of the candidate agent to the CAP.


Further provided herein is a method for screening for a bioactive agent capable of modulating the activity of a CAP. In one embodiment, the method comprises combining the CAP and a candidate bioactive agent, and determining the effect of the candidate agent on the bioactivity of the CAP.


Also provided is a method of evaluating the effect of a candidate cancer drug comprising administering the drug to a patient and removing a cell sample from the patient. The expression profile of the cell is then determined. This method may further comprise comparing the expression profile of the patient to an expression profile of a healthy individual.


In a further aspect, a method for inhibiting the activity of a CA protein is provided. In one embodiment, the method comprises administering to a patient an inhibitor of a CA protein preferably selected from the group consisting of the sequences outlined in Tables 1-7 (SEQ ID NOS: 8, 10, 18, 20, 22, 28, 30, 42, 44, 46, 48, 54, 62, 68, 70, 72 and 74).


A method of neutralizing the effect of a CA protein, preferably a protein encoded by a nucleic acid selected from the group of sequences outlined in Tables 1-7 (human genomic sequences of SEQ ID NOS: 6, 16, 26, 40, 52, 60 and 66, and sequences of SEQ ID NOS: 7, 9, 17, 19, 21, 27, 29, 41, 43, 45, 47, 53, 61, 67, 69, 71 and 73 corresponding to the human mRNAs generated therefrom), is also provided. Preferably, the method comprises contacting an agent specific for said protein with said protein in an amount sufficient to effect neutralization.


Moreover, provided herein is a biochip comprising a nucleic acid segment which encodes a CA protein, preferably selected from the sequences outlined in Tables 1-7 (SEQ ID NOS: 7, 9, 17, 19, 21, 27, 29, 41, 43, 45, 47, 53, 61, 67, 69, 71 and 73).


Also provided herein is a method for diagnosing or determining the propensity to cancers, especially lymphoma or leukemia or carcinoma by sequencing at least one carcinoma or lymphoma gene of an individual. In yet another aspect of the invention, a method is provided for determining cancer including lymphoma and leukemia gene copy numbers in an individual.


The invention provides an isolated nucleic acid comprising at least 10, 12, 15, 20 or 30 contiguous nucleotides of a sequence selected from the group consisting of the polynucleotide sequences SEQ ID NOS: 7, 9, 17, 19, 21, 27, 29, 41, 43, 45, 47, 53, 61, 67, 69, 71 and 73 shown in Tables 1-7, or its complement, or an expression vector comprising the isolated nucleic acids and host cells comprising them.


In some embodiments, the polynucleotide, or its complement or a fragment thereof, further comprises a detectable label, is attached to a solid support, is prepared at least in part by chemical synthesis, is an antisense fragment, is single stranded, is double stranded or comprises a microarray.


The invention provides an isolated polypeptide, encoded within an open reading frame of a CA sequence selected from the group consisting of the polynucleotide sequences of SEQ ID NOS: 6, 16, 26, 40, 52, 60 and 66 shown in Tables 1-7, or its complement. The invention provides an isolated polypeptide, wherein said polypeptide comprises the amino acid sequence encoded by a polynucleotide selected from the group consisting of SEQ ID NOS: 7, 9, 17, 19, 21, 27, 29, 41, 43, 45, 47, 53, 61, 67, 69, 71 and 73 shown in Tables 1-7. The invention provides an isolated polypeptide, wherein said polypeptide comprises the amino acid sequence encoded by a polypeptide selected from the group consisting of SEQ ID NOS: 8, 10, 18, 20, 22, 28, 30, 42, 44, 46, 48, 54, 62, 68, 70, 72 and 74 shown in Tables 1-7.


The invention further provides an isolated polypeptide, comprising the amino acid sequence of an epitope of the amino acid sequence of a CA polypeptide selected from the group consisting of SEQ ID NOS: 8, 10, 18, 20, 22, 28, 30, 42, 44, 46, 48, 54, 62, 68, 70, 72 and 74 shown in Tables 1-7, wherein the polypeptide or fragment thereof may be attached to a solid support. In one embodiment the invention provides an isolated antibody (monoclonal or polyclonal) or antigen binding fragment thereof, that binds to such a polypeptide. The isolated antibody or antigen binding fragment thereof may be attached to a solid support, or further comprises a detectable label.


In one embodiment, the invention provides a kit for diagnosing the presence of cancer in a test sample, said kit comprising at least one polynucleotide that selectively hybridizes to a CA polynucleotide sequence shown in Tables 1-7, or its complement. In another embodiment, the invention provides an electronic library comprising a CA polynucleotide, a CA polypeptide, or fragment thereof, shown in Tables 1-7.


In one embodiment, the invention provides a method of screening for anticancer activity comprising: (a) providing a cell that expresses a cancer associated (CA) gene encoded by a nucleic acid sequence selected from the group consisting of the CA sequences shown in Tables 1-7, or fragment thereof; (b) contacting a tissue sample derived from a cancer cell with an anticancer drug candidate; (c) monitoring an effect of the anticancer drug candidate on an expression of the CA polynucleotide in the tissue sample, and optionally (d) comparing the level of expression in the absence of said drug candidate to the level of expression in the presence of the drug candidate.


In one embodiment, the invention provides a method for detecting cancer associated with expression of a polypeptide in a test cell sample, comprising the steps of: (i) detecting a level of expression of at least one polypeptide selected from the group consisting of SEQ ID NOS: 8, 10, 18, 20, 22, 28, 30, 42, 44, 46, 48, 54, 62, 68, 70, 72 and 74 shown in Tables 1-7, or a fragment thereof; and (ii) comparing the level of expression of the polypeptide in the test sample with a level of expression of polypeptide in a normal cell sample, wherein an altered level of expression of the polypeptide in the test cell sample relative to the level of polypeptide expression in the normal cell sample is indicative of the presence of cancer in the test cell sample.


In another embodiment, the invention provides a method for detecting cancer associated with expression of a polypeptide in a test cell sample, comprising the steps of: (i) detecting a level of activity of at least one polypeptide selected from the group consisting of SEQ ID NOS: 8, 10, 18, 20, 22, 28, 30, 42, 44, 46, 48, 54, 62, 68, 70, 72 and 74 shown in Tables 1-7, or a fragment thereof, wherein said activity corresponds to at least one activity for the polypeptide listed in Table 9; and (ii) comparing the level of activity of the polypeptide in the test sample with a level of activity of polypeptide in a normal cell sample, wherein an altered level of activity of the polypeptide in the test cell sample relative to the level of polypeptide activity in the normal cell sample is indicative of the presence of cancer in the test cell sample.


In another embodiment, the invention provides a method for detecting cancer associated with the presence of an antibody in a test serum sample, comprising the steps of: (i) detecting a level of an antibody against an antigenic polypeptide selected from the group consisting of SEQ ID NOS: 8, 10, 18, 20, 22, 28, 30, 42, 44, 46, 48, 54, 62, 68, 70, 72 and 74 shown in Tables 1-7, or antigenic fragment thereof; and (ii) comparing said level of said antibody in the test sample with a level of said antibody in the control sample, wherein an altered level of antibody in said test sample relative to the level of antibody in the control sample is indicative of the presence of cancer in the test serum sample.


The invention provides a method for screening for a bioactive agent capable of modulating the activity of a CA protein (CAP), wherein said CAP is encoded by a nucleic acid comprising a nucleic acid sequence selected from the group consisting of the polynucleotide sequences SEQ ID NOS: 7, 9, 17, 19, 21, 27, 29, 41, 43, 45, 47, 53, 61, 67, 69, 71 and 73 shown in Tables 1-7, said method comprising: a) combining said CAP and a candidate bioactive agent; and b) determining the effect of the candidate agent on the bioactivity of said CAP. According to the method the bioactive agent: affects the expression of the CA protein (CAP); affects the activity of the CA protein (CAP), wherein such activity is selected from the activities listed in Table 9.


In one embodiment, the invention provides a method for diagnosing cancer comprising: a) determining the expression of one or more genes comprising a nucleic acid sequence selected from the group consisting of the human genomic and mRNA sequences outlined in Tables 1-7, in a first tissue type of a first individual; and b) comparing said expression of said gene(s) from a second normal tissue type from said first individual or a second unaffected individual; wherein a difference in said expression indicates that the first individual has cancer.


In another embodiment the invention provides a method for treating cancers comprising administering to a patient a bioactive agent modulating the activity of a CA protein (CAP), wherein said CAP is encoded by a nucleic acid comprising a nucleic acid sequence selected from the group consisting of the human nucleic acid sequences in Tables 1-7 and further wherein the bioactive agent binds to the CA protein, wherein the CA protein: is a signalling protein wherein the CAP sequence is selected from the group consisting of SEQ ID NOS: 6, 12, 14, 96, 130, 172 and 174 shown in Tables 1-7; is involved in signal transduction wherein the CAP sequence is selected from the group consisting of SEQ ID NOS: 20, 84, 90, 92, 94, 96, 98, 100, 102, 104, 106, and 108; is a cell adhesion protein wherein the CAP sequence is selected from the group consisting of SEQ ID NOS: 36, 38, 40, 84, 90, 92, 94, 96, 98, 100, 102, 104, 106, 108, 124, 172, and 174; is involved in inflammatory response wherein the CAP sequence is selected from the group consisting of SEQ ID NOS: 62, 64, 66, 68, 72, 74, and 76; is involved in pheromone response wherein the CAP sequence is selected from the group consisting of SEQ ID NOS: 138, 140, 142, 144, 146, 148, and 150; is an ion transport protein wherein the CAP sequence is selected from the group consisting of SEQ ID NOS: 28, 30, 114, and 118 as shown in Tables 1-7.


The invention provides monoclonal antibodies that preferentially binds to a CA protein (CAP) that is expressed on a cell surface, wherein the CA protein selected from the group consisting of SEQ ID NOS: 8, 10, 18, 20, 22, 28, 30, 42, 44, 46, 48, 54, 62, 68, 70, 72 and 74; preferably to the extracellular domain of the CA protein; preferably to a CA protein differentially expressed on a cancer cell surface relative to a normal cell surface or preferably to at least one human cancer cell line; preferably linked to a therapeutic agent; or preferably humanized. Kits and pharmaceutical compositions for detecting a presence or an absence of cancer cells in an individual, and comprising such antibodies are also provided.


The invention also provides a method for detecting a presence or an absence of cancer cells in an individual, the method comprising: contacting cells from the individual with the antibody according to the invention; and detecting a complex of a CAP from the cancer cells and the antibody, wherein detection of the complex correlates with the presence of cancer cells in the individual. In one embodiment the invention provides a method for inhibiting growth of cancer cells in an individual, the method comprising: administering to the individual an effective amount of a pharmaceutical composition according to the invention. In another embodiment the invention provides a method for delivering a therapeutic agent to cancer cells in an individual, the method comprising: administering to the individual an effective amount of a pharmaceutical composition according to according to the invention.


Novel sequences associated with cancer are also provided herein. Other aspects of the invention will become apparent to the skilled artisan by the following description of the invention.




BRIEF DESCRIPTION OF THE FIGURES


FIG. 1 depicts PCR amplification of host-provirus junction fragments.



FIG. 2 shows an example of average threshold cycle (CT) values for a housekeeper gene and target gene.



FIG. 3 shows an example of the calculated difference (AACT) between the CT values of target and housekeeper genes (ACT) for various samples.



FIG. 4 shows the AACT and comparative expression level for each sample from FIG. 3.




DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS

The present invention is directed to a number of sequences associated with cancers, especially lymphoma, breast cancer or prostate cancer. The relatively tight linkage between clonally-integrated proviruses and protooncogenes forms “provirus tagging”, in which slow-transforming retroviruses that act by an insertion mutation mechanism are used to isolate protooncogenes. In some models, uninfected animals have low cancer rates, and infected animals have high cancer rates. It is known that many of the retroviruses involved do not carry transduced host protooncogenes or pathogenic trans-acting viral genes, and thus the cancer incidence must therefore be a direct consequence of proviral integration effects into host protooncogenes. Since proviral integration is random, rare integrants will “activate” host protooncogenes that provide a selective growth advantage, and these rare events result in new proviruses at clonal stoichiometries in tumors. In contrast to mutations caused by chemicals, radiation, or spontaneous errors, protooncogene insertion mutations can be easily located by virtue of the fact that a convenient-sized genetic marker of known sequence (the provirus) is present at the site of mutation. Host sequences that flank clonally integrated proviruses can be cloned using a variety of strategies. Once these sequences are in hand, the tagged protooncogenes can be subsequently identified. The presence of provirus at the same locus in two or more independent tumors is prima facie evidence that a protooncogene is present at or very near the provirus integration sites. This is because the genome is too large for random integrations to result in observable clustering. Any clustering that is detected is unequivocal evidence for biological selection (i.e. the tumor phenotype). Moreover, the pattern of proviral integrants (including orientations) provides compelling positional information that makes localization of the target gene at each cluster relatively simple. The three mammalian retroviruses that are known to cause cancer by an insertion mutation mechanism are FeLV (leukemia/lymphoma in cats), MLV (leukemia/lymphoma in mice and rats), and MMTV (mammary cancer in mice).


Thus, the use of oncogenic retroviruses, whose sequences insert into the genome of the host organism resulting in cancer, allows the identification of host sequences involved in cancer. These sequences may then be used in a number of different ways, including diagnosis, prognosis, screening for modulators (including both agonists and antagonists), antibody generation (for immunotherapy and imaging), etc. However, as will be appreciated by those in the art, oncogenes that are identified in one type of cancer such as lymphoma or leukemia have a strong likelihood of being involved in other types of cancers as well. Thus, while the sequences outlined herein are initially identified as correlated with lymphoma, they can also be found in other types of cancers as well, outlined below.


Definitions


Accordingly, the present invention provides nucleic acid and protein sequences that are associated with cancer, herein termed “cancer associated” or “CA” sequences. In one embodiment, the present invention provides nucleic acid and protein sequences that are associated with cancers that originate in lymphatic tissue, herein termed “lymphoma associated,” “leukemia associated” or “LA” sequences. In another embodiment, the present invention provides nucleic acid and protein sequences that are associated with carcinomas which originate in breast tissue, herein termed “breast cancer associated” or “BC” sequences.


Suitable cancers that can be diagnosed or screened for using the methods of the present invention include cancers classified by site or by histological type. Cancers classified by site include cancer of the oral cavity and pharynx (lip, tongue, salivary gland, floor of mouth, gum and other mouth, nasopharynx, tonsil, oropharynx, hypopharynx, other oral/pharynx); cancers of the digestive system (esophagus; stomach; small intestine; colon and rectum; anus, anal canal, and anorectum; liver; intrahepatic bile duct; gallbladder; other biliary; pancreas; retroperitoneum; peritoneum, omentum, and mesentery; other digestive); cancers of the respiratory system (nasal cavity, middle ear, and sinuses; larynx; lung and bronchus; pleura; trachea, mediastinum, and other respiratory); cancers of the mesothelioma; bones and joints; and soft tissue, including heart; skin cancers, including melanomas and other non-epithelial skin cancers; Kaposi's sarcoma and breast cancer; cancer of the female genital system (cervix uteri; corpus uteri; uterus, nos; ovary; vagina; vulva; and other female genital); cancers of the male genital system (prostate gland; testis; penis; and other male genital); cancers of the urinary system (urinary bladder; kidney and renal pelvis; ureter; and other urinary); cancers of the eye and orbit; cancers of the brain and nervous system (brain; and other nervous system); cancers of the endocrine system (thyroid gland and other endocrine, including thymus); lymphomas (Hodgkin's disease and non-Hodgkin's lymphoma), multiple myeloma, and leukemias (lymphocytic leukemia; myeloid leukemia; monocytic leukemia; and other leukemias).


Other cancers, classified by histological type, that may be associated with the sequences of the invention include, but are not limited to, Neoplasm, malignant; Carcinoma, NOS; Carcinoma, undifferentiated, NOS; Giant and spindle cell carcinoma; Small cell carcinoma, NOS; Papillary carcinoma, NOS; Squamous cell carcinoma, NOS; Lymphoepithelial carcinoma; Basal cell carcinoma, NOS; Pilomatrix carcinoma; Transitional cell carcinoma, NOS; Papillary transitional cell carcinoma; Adenocarcinoma, NOS; Gastrinoma, malignant; Cholangiocarcinoma; Hepatocellular carcinoma, NOS; Combined hepatocellular carcinoma and cholangiocarcinoma; Trabecular adenocarcinoma; Adenoid cystic carcinoma; Adenocarcinoma in adenomatous polyp; Adenocarcinoma, familial polyposis coli; Solid carcinoma, NOS; Carcinoid tumor, malignant; Bronchiolo-alveolar adenocarcinoma; Papillary adenocarcinoma, NOS; Chromophobe carcinoma; Acidophil carcinoma; Oxyphilic adenocarcinoma; Basophil carcinoma; Clear cell adenocarcinoma, NOS; Granular cell carcinoma; Follicular adenocarcinoma, NOS; Papillary and follicular adenocarcinoma; Nonencapsulating sclerosing carcinoma; Adrenal cortical carcinoma; Endometroid carcinoma; Skin appendage carcinoma; Apocrine adenocarcinoma; Sebaceous adenocarcinoma; Ceruminous adenocarcinoma; Mucoepidermoid carcinoma; Cystadenocarcinoma, NOS; Papillary cystadenocarcinoma, NOS; Papillary serous cystadenocarcinoma; Mucinous cystadenocarcinoma, NOS; Mucinous adenocarcinoma; Signet ring cell carcinoma; Infiltrating duct carcinoma; Medullary carcinoma, NOS; Lobular carcinoma; Inflammatory carcinoma; Paget's disease, mammary; Acinar cell carcinoma; Adenosquamous carcinoma; Adenocarcinoma w/squamous metaplasia; Thymoma, malignant; Ovarian stromal tumor, malignant; Thecoma, malignant; Granulosa cell tumor, malignant; Androblastoma, malignant; Sertoli cell carcinoma; Leydig cell tumor, malignant; Lipid cell tumor, malignant; Paraganglioma, malignant; Extra-mammary paraganglioma, malignant; Pheochromocytoma; Glomangiosarcoma; Malignant melanoma, NOS; Amelanotic melanoma; Superficial spreading melanoma; Malig melanoma in giant pigmented nevus; Epithelioid cell melanoma; Blue nevus, malignant; Sarcoma, NOS; Fibrosarcoma, NOS; Fibrous histiocytoma, malignant; Myxosarcoma; Liposarcoma, NOS; Leiomyosarcoma, NOS; Rhabdomyosarcoma, NOS; Embryonal rhabdomyosarcoma; Alveolar rhabdomyosarcoma; Stromal sarcoma, NOS; Mixed tumor, malignant, NOS; Mullerian mixed tumor; Nephroblastoma; Hepatoblastoma; Carcinosarcoma, NOS; Mesenchymoma, malignant; Brenner tumor, malignant; Phyllodes tumor, malignant; Synovial sarcoma, NOS; Mesothelioma, malignant; Dysgerminoma; Embryonal carcinoma, NOS; Teratoma, malignant, NOS; Struma ovarii, malignant; Choriocarcinoma; Mesonephroma, malignant; Hemangiosarcoma; Hemangioendothelioma, malignant; Kaposi's sarcoma; Hemangiopericytoma, malignant; Lymphangiosarcoma; Osteosarcoma, NOS; Juxtacortical osteosarcoma; Chondrosarcoma, NOS; Chondroblastoma, malignant; Mesenchymal chondrosarcoma; Giant cell tumor of bone; Ewing's sarcoma; Odontogenic tumor, malignant; Ameloblastic odontosarcoma; Ameloblastoma, malignant; Ameloblastic fibrosarcoma; Pinealoma, malignant; Chordoma; Glioma, malignant; Ependymoma, NOS; Astrocytoma, NOS; Protoplasmic astrocytoma; Fibrillary astrocytoma; Astroblastoma; Glioblastoma, NOS; Oligodendroglioma, NOS; Oligodendroblastoma; Primitive neuroectodermal; Cerebellar sarcoma, NOS; Ganglioneuroblastoma; Neuroblastoma, NOS; Retinoblastoma, NOS; Olfactory neurogenic tumor; Meningioma, malignant; Neurofibrosarcoma; Neurilemmoma, malignant; Granular cell tumor, malignant; Malignant lymphoma, NOS; Hodgkin's disease, NOS; Hodgkin's; paragranuloma, NOS; Malignant lymphoma, small lymphocytic; Malignant lymphoma, large cell, diffuse; Malignant lymphoma, follicular, NOS; Mycosis fungoides; Other specified non-Hodgkin's lymphomas; Malignant histiocytosis; Multiple myeloma; Mast cell sarcoma; Immunoproliferative small intestinal disease; Leukemia, NOS; Lymphoid leukemia, NOS; Plasma cell leukemia; Erythroleukemia; Lymphosarcoma cell leukemia; Myeloid leukemia, NOS; Basophilic leukemia; Eosinophilic leukemia; Monocytic leukemia, NOS; Mast cell leukemia; Megakaryoblastic leukemia; Myeloid sarcoma; and Hairy cell leukemia.


In addition, the CA genes may be involved in other diseases such as, but not limited to, diseases associated with aging or neurodegeneration.


“Association” in this context means that the nucleotide or protein sequences are either differentially expressed, activated, inactivated or altered in cancers as compared to normal tissue. As outlined below, CA sequences include those that are up-regulated (i.e. expressed at a higher level), as well as those that are down-regulated (i.e. expressed at a lower level), in cancers. CA sequences also include sequences that have been altered (i.e., truncated sequences or sequences with substitutions, deletions or insertions, including point mutations) and show either the same expression profile or an altered profile. In a preferred embodiment, the CA sequences are from humans; however, as will be appreciated by those in the art, CA sequences from other organisms may be useful in animal models of disease and drug evaluation; thus, other CA sequences are provided, from vertebrates, including mammals, including rodents (rats, mice, hamsters, guinea pigs, etc.), primates, and farm animals (including sheep, goats, pigs, cows, horses, etc). In some cases, prokaryotic CA sequences may be useful. CA sequences from other organisms may be obtained using the techniques outlined below.


CA sequences include both nucleic acid and amino acid sequences. In a preferred embodiment, the CA sequences are recombinant nucleic acids. By the term “recombinant nucleic acid” herein is meant nucleic acid, originally formed in vitro, in general, by the manipulation of nucleic acid by polymerases and endonucleases, in a form not normally found in nature. Thus a recombinant nucleic acid is also an isolated nucleic acid, in a linear form, or cloned in a vector formed in vitro by ligating DNA molecules that are not normally joined, are both considered recombinant for the purposes of this invention. It is understood that once a recombinant nucleic acid is made and reintroduced into a host cell or organism, it will replicate using the in vivo cellular machinery of the host cell rather than in vitro manipulations; however, such nucleic acids, once produced recombinantly, although subsequently replicated in vivo, are still considered recombinant or isolated for the purposes of the invention. As used herein a “polynucleotide” or “nucleic acid” is a polymeric form of nucleotides of any length, either ribonucleotides or deoxyribonucleotides. This term refers only to the primary structure of the molecule. Thus, this term includes double- and single-stranded DNA and RNA. It also includes known types of modifications, for example, labels which are known in the art, methylation, “caps”, substitution of one or more of the naturally occurring nucleotides with an analog, internucleotide modifications such as, for example, those with uncharged linkages (e.g., phosphorothioates, phosphorodithioates, etc.), those containing pendant moieties, such as, for example proteins (including e.g., nucleases, toxins, antibodies, signal peptides, poly-L-lysine, etc.), those with intercalators (e.g., acridine, psoralen, etc.), those containing chelators (e.g., metals, radioactive metals, etc.), those containing alkylators, those with modified linkages (e.g., alpha anomeric nucleic acids, etc.), as well as unmodified forms of the polynucleotide.


As used herein, a polynucleotide “derived from” a designated sequence refers to a polynucleotide sequence which is comprised of a sequence of approximately at least about 6 nucleotides, preferably at least about 8 nucleotides, more preferably at least about 10-12 nucleotides, and even more preferably at least about 15-20 nucleotides corresponding to a region of the designated nucleotide sequence. “Corresponding” means homologous to or complementary to the designated sequence. Preferably, the sequence of the region from which the polynucleotide is derived is homologous to or complementary to a sequence that is unique to a CA gene.


Similarly, a “recombinant protein” is a protein made using recombinant techniques, i.e. through the expression of a recombinant nucleic acid as depicted above. A recombinant protein is distinguished from naturally occurring protein by at least one or more characteristics. For example, the protein may be isolated or purified away from some or all of the proteins and compounds with which it is normally associated in its wild type host, and thus may be substantially pure. For example, an isolated protein is unaccompanied by at least some of the material with which it is normally associated in its natural state, preferably constituting at least about 0.5%, more preferably at least about 5% by weight of the total protein in a given sample. A substantially pure protein comprises about 50-75% by weight of the total protein, with about 80% being preferred, and about 90% being particularly preferred. The definition includes the production of a CA protein from one organism in a different organism or host cell. Alternatively, the protein may be made at a significantly higher concentration than is normally seen, through the use of an inducible promoter or high expression promoter, such that the protein is made at increased concentration levels. Alternatively, the protein may be in a form not normally found in nature, as in the addition of an epitope tag or amino acid substitutions, insertions and deletions, as discussed below.


In a preferred embodiment, the CA sequences are nucleic acids. As will be appreciated by those in the art and is more fully outlined below, CA sequences are useful in a variety of applications, including diagnostic applications, which will detect naturally occurring nucleic acids, as well as screening applications; for example, biochips comprising nucleic acid probes to the CA sequences can be generated. In the broadest sense, use of “nucleic acid,” “polynucleotide” or “oligonucleotide” or equivalents herein means at least two nucleotides covalently linked together. In some embodiments, an oligonucleotide is an oligomer of 6, 8, 10, 12, 20, 30 or up to 100 nucleotides. A “polynucleotide” or “oligonucleotide” may comprise DNA, RNA, PNA or a polymer of nucleotides linked by phosphodiester and/or any alternate bonds.


A nucleic acid of the present invention generally contains phosphodiester bonds, although in some cases, as outlined below (for example, in antisense applications or when a nucleic acid is a candidate drug agent), nucleic acid analogs may have alternate backbones, comprising, for example, phosphoramidate (Beaucage et al., Tetrahedron 49(10):1925 (1993) and references therein; Letsinger, J. Org. Chem. 35:3800 (1970); Sprinzl et al., Eur. J. Biochem. 81:579 (1977); Letsinger et al., Nucl. Acids Res. 14:3487 (1986); Sawai et al, Chem. Lett. 805 (1984), Letsinger et al., J. Am. Chem. Soc. 110:4470 (1988); and Pauwels et al., Chemica Scripta 26:141 91986)), phosphorothioate (Mag et al., Nucleic Acids Res. 19:1437 (1991); and U.S. Pat. No. 5,644,048), phosphorodithioate (Briu et al., J. Am. Chem. Soc; 111:2321 (1989), O-methylphosphoroamidite linkages (see Eckstein, Oligonucleotides and Analogues: A Practical Approach, Oxford University Press), and peptide nucleic acid backbones and linkages (see Egholm, J. Am. Chem. Soc. 114:1895 (1992); Meier et al., Chem. Int. Ed. Engl. 31:1008 (1992); Nielsen, Nature, 365:566 (1993); Carlsson et al., Nature 380:207 (1996), all of which are incorporated by reference). Other analog nucleic acids include those with positive backbones (Denpcy et al., Proc. Natl. Acad. Sci. USA 92:6097 (1995); non-ionic backbones (U.S. Pat. Nos. 5,386,023, 5,637,684, 5,602,240, 5,216,141 and 4,469,863; Kiedrowshi et al., Angew. Chem. Intl. Ed. English 30:423 (1991); Letsinger et al., J. Am. Chem. Soc. 110:4470 (1988); Letsinger et al., Nucleoside & Nucleotide 13:1597 (1994); Chapters 2 and 3, ASC Symposium Series 580, “Carbohydrate Modifications in Antisense Research”, Ed. Y. S. Sanghui and P. Dan Cook; Mesmaeker et al., Bioorganic & Medicinal Chem. Lett. 4:395 (1994); Jeffs et al., J. Biomolecular NMR 34:17 (1994); Tetrahedron Lett. 37:743 (1996)) and non-ribose backbones, including those described in U.S. Pat. Nos. 5,235,033 and 5,034,506, and Chapters 6 and 7, ASC Symposium Series 580, “Carbohydrate Modifications in Antisense Research”, Ed. Y. S. Sanghui and P. Dan Cook. Nucleic acids containing one or more carbocyclic sugars are also included within one definition of nucleic acids (see Jenkins et al., Chem. Soc. Rev. (1995) pp 169-176). Several nucleic acid analogs are described in Rawls, C & E News Jun. 2, 1997 page 35. All of these references are hereby expressly incorporated by reference. These modifications of the ribose-phosphate backbone may be done for a variety of reasons, for example to increase the stability and half-life of such molecules in physiological environments for use in anti-sense applications or as probes on a biochip.


As will be appreciated by those in the art, all of these nucleic acid analogs may find use in the present invention. In addition, mixtures of naturally occurring nucleic acids and analogs can be made; alternatively, mixtures of different nucleic acid analogs, and mixtures of naturally occurring nucleic acids and analogs may be made.


The nucleic acids may be single stranded or double stranded, as specified, or contain portions of both double stranded or single stranded sequence. As will be appreciated by those in the art, the depiction of a single strand “Watson” also defines the sequence of the other strand “Crick”; thus the sequences described herein also includes the complement of the sequence. The nucleic acid may be DNA, both genomic and cDNA, RNA, or a hybrid, where the nucleic acid contains any combination of deoxyribo- and ribo-nucleotides, and any combination of bases, including uracil, adenine, thymine, cytosine, guanine, inosine, xanthine, hypoxanthine, isocytosine, isoguanine, etc. As used herein, the term “nucleoside” includes nucleotides and nucleoside and nucleotide analogs, and modified nucleosides such as amino modified nucleosides. In addition, “nucleoside” includes non-naturally occurring analog structures. Thus for example the individual units of a peptide nucleic acid, each containing a base, are referred to herein as a nucleoside.


As used herein, the term “tag,” “sequence tag” or “primer tag sequence” refers to an oligonucleotide with specific nucleic acid sequence that serves to identify a batch of polynucleotides bearing such tags therein. Polynucleotides from the same biological source are covalently tagged with a specific sequence tag so that in subsequent analysis the polynucleotide can be identified according to its source of origin. The sequence tags also serve as primers for nucleic acid amplification reactions.


A “microarray” is a linear or two-dimensional array of preferably discrete regions, each having a defined area, formed on the surface of a solid support. The density of the discrete regions on a microarray is determined by the total numbers of target polynucleotides to be detected on the surface of a single solid phase support, preferably at least about 50/cm2, more preferably at least about 100/cm2, even more preferably at least about 500/cm2, and still more preferably at least about 1,000/cm2. As used herein, a DNA microarray is an array of oligonucleotide primers placed on a chip or other surfaces used to amplify or clone target polynucleotides. Since the position of each particular group of primers in the array is known, the identities of the target polynucleotides can be determined based on their binding to a particular position in the microarray.


A “linker” is a synthetic oligodeoxyribonucleotide that contains a restriction site. A linker may be blunt end-ligated onto the ends of DNA fragments to create restriction sites that can be used in the subsequent cloning of the fragment into a vector molecule.


The term “label” refers to a composition capable of producing a detectable signal indicative of the presence of the target polynucleotide in an assay sample. Suitable labels include radioisotopes, nucleotide chromophores, enzymes, substrates, fluorescent molecules, chemiluminescent moieties, magnetic particles, bioluminescent moieties, and the like. As such, a label is any composition detectable by spectroscopic, photochemical, biochemical, immunochemical, electrical, optical, chemical, or any other appropriate means. The term “label” is used to refer to any chemical group or moiety having a detectable physical property or any compound capable of causing a chemical group or moiety to exhibit a detectable physical property, such as an enzyme that catalyzes conversion of a substrate into a detectable product. The term “label” also encompasses compounds that inhibit the expression of a particular physical property. The label may also be a compound that is a member of a binding pair, the other member of which bears a detectable physical property.


The term “support” refers to conventional supports such as beads, particles, dipsticks, fibers, filters, membranes, and silane or silicate supports such as glass slides.


The term “amplify” is used in the broad sense to mean creating an amplification product which may include, for example, additional target molecules, or target-like molecules or molecules complementary to the target molecule, which molecules are created by virtue of the presence of the target molecule in the sample. In the situation where the target is a nucleic acid, an amplification product can be made enzymatically with DNA or RNA polymerases or reverse transcriptases.


As used herein, a “biological sample” refers to a sample of tissue or fluid isolated from an individual, including but not limited to, for example, blood, plasma, serum, spinal fluid, lymph fluid, skin, respiratory, intestinal and genitourinary tracts, tears, saliva, milk, cells (including but not limited to blood cells), tumors, organs, and also samples of in vitro cell culture constituents.


The term “biological sources” as used herein refers to the sources from which the target polynucleotides are derived. The source can be of any form of “sample” as described above, including but not limited to, cell, tissue or fluid. “Different biological sources” can refer to different cells/tissues/organs of the same individual, or cells/tissues/organs from different individuals of the same species, or cells/tissues/organs from different species.


Cancer-Associated Sequences


The CA sequences of the invention were initially identified by infection of mice with a retrovirus such as murine leukemia virus (MLV) resulting in lymphoma. Retroviruses have a genome that is made out of RNA. After a retrovirus infects a host cell, a double stranded DNA copy of the retrovirus genome (a “provirus”) is inserted into the genomic DNA of the host cell. The integrated provirus may affect the expression of host genes at or near the site of integration—a phenomenon known as retroviral insertional mutagenesis. Possible changes in the expression of host cell genes include: (i) increased expression of genes near the site of integration resulting from the proximity of elements in the provirus that act as transcriptional promoters and enhancers, (ii) functional inactivation of a gene caused by the integration of a provirus into the gene itself thus preventing the synthesis of a functional gene product, or (iii) expression of a mutated protein that has a different activity to the normal protein. Typically such a protein would be prematurely truncated and lack a regulatory domain near the C terminus. Such a protein might be constitutively active, or act as a dominant negative inhibitor of the normal protein. For example, retrovirus enhancers, including that of SL3-3, are known to act on genes up to approximately 200 kilobases from the insertion site. Moreover, many of these sequences are also involved in other cancers and disease states. Sequences of mouse genes according to this invention, that are identified in this manner are shown as mDxx-yyy in Tables 1-7.


A CA sequence can be initially identified by substantial nucleic acid and/or amino acid sequence homology to the CA sequences outlined herein. Such homology can be based upon the overall nucleic acid or amino acid sequence, and is generally determined as outlined below, using either homology programs or hybridization conditions.


In one embodiment, CA sequences are those that are up-regulated in cancers; that is, the expression of these genes is higher in cancer tissue as compared to normal tissue of the same differentiation stage. “Up-regulation” as used herein means increased expression by about 50%, preferably about 100%, more preferably about 150% to about 200%, with up-regulation from 300% to 1000% being preferred.


In another embodiment, CA sequences are those that are down-regulated in cancers; that is, the expression of these genes is lower in cancer tissue as compared to normal tissue of the same differentiation stage. “Down-regulation” as used herein means decreased expression by about 50%, preferably about 100%, more preferably about 150% to about 200%, with down-regulation from 300% to 1000% to no expression being preferred.


In yet another embodiment, CA sequences are those that have altered sequences but show either the same or an altered expression profile as compared to normal lymphoid tissue of the same differentiation stage. “Altered CA sequences” as used herein also refers to sequences that are truncated, contain insertions or contain point mutations.


CA proteins of the present invention may be classified as secreted proteins, transmembrane proteins or intracellular proteins. In a preferred embodiment the CA protein is an intracellular protein. Intracellular proteins may be found in the cytoplasm and/or in the nucleus. Intracellular proteins are involved in all aspects of cellular function and replication (including, for example, signaling pathways); aberrant expression of such proteins results in unregulated or disregulated cellular processes. For example, many intracellular proteins have enzymatic activity such as protein kinase activity, protein phosphatase activity, protease activity, nucleotide cyclase activity, polymerase activity and the like. Intracellular proteins also serve as docking proteins that are involved in organizing complexes of proteins, or targeting proteins to various subcellular localizations, and are involved in maintaining the structural integrity of organelles.


An increasingly appreciated concept in characterizing intracellular proteins is the presence in the proteins of one or more motifs for which defined functions have been attributed. In addition to the highly conserved sequences found in the enzymatic domain of proteins, highly conserved sequences have been identified in proteins that are involved in protein-protein interaction. For example, Src-homology-2 (SH2) domains bind tyrosine-phosphorylated targets in a sequence dependent manner. PTB domains, which are distinct from SH2 domains, also bind tyrosine phosphorylated targets. SH3 domains bind to proline-rich targets. In addition, PH domains, tetratricopeptide repeats and WD domains to name only a few, have been shown to mediate protein-protein interactions. Some of these may also be involved in binding to phospholipids or other second messengers. As will be appreciated by one of ordinary skill in the art, these motifs can be identified on the basis of primary sequence; thus, an analysis of the sequence of proteins may provide insight into both the enzymatic potential of the molecule and/or molecules with which the protein may associate.


In a preferred embodiment, the CA sequences are transmembrane proteins. Transmembrane proteins are molecules that span the phospholipid bilayer of a cell. They may have an intracellular domain, an extracellular domain, or both. The intracellular domains of such proteins may have a number of functions including those already described for intracellular proteins. For example, the intracellular domain may have enzymatic activity and/or may serve as a binding site for additional proteins. Frequently the intracellular domain of transmembrane proteins serves both roles. For example certain receptor tyrosine kinases have both protein kinase activity and SH2 domains. In addition, autophosphorylation of tyrosines on the receptor molecule itself creates binding sites for additional SH2 domain containing proteins.


Transmembrane proteins may contain from one to many transmembrane domains. For example, receptor tyrosine kinases, certain cytokine receptors, receptor guanylyl cyclases and receptor serine/threonine protein kinases contain a single transmembrane domain. However, various other proteins including channels and adenylyl cyclases contain numerous transmembrane domains. Many important cell surface receptors are classified as “seven transmembrane domain” proteins, as they contain 7 membrane spanning regions. Important transmembrane protein receptors include, but are not limited to insulin receptor, insulin-like growth factor receptor, human growth hormone receptor, glucose transporters, transferrin receptor, epidermal growth factor receptor, low density lipoprotein receptor, leptin receptor, interleukin receptors, e.g. IL-1 receptor, IL-2 receptor, etc. CA proteins may be derived from genes that regulate apoptosis (IL-3, GM-CSF and Bcl-x) or are shown to have a role in the regulation of apoptosis.


Characteristics of transmembrane domains include approximately 20 consecutive hydrophobic amino acids that may be followed by charged amino acids. Therefore, upon analysis of the amino acid sequence of a particular protein, the localization and number of transmembrane domains within the protein may be predicted.


The extracellular domains of transmembrane proteins are diverse; however, conserved motifs are found repeatedly among various extracellular domains. Conserved structure and/or functions have been ascribed to different extracellular motifs. For example, cytokine receptors are characterized by a cluster of cysteines and a WSXWS (W=tryptophan, S=serine, X=any amino acid) motif. Immunoglobulin-like domains are highly conserved. Mucin-like domains may be involved in cell adhesion and leucine-rich repeats participate in protein-protein interactions.


Many extracellular domains are involved in binding to other molecules. In one aspect, extracellular domains are receptors. Factors that bind the receptor domain include circulating ligands, which may be peptides, proteins, or small molecules such as adenosine and the like. For example, growth factors such as EGF, FGF and PDGF are circulating growth factors that bind to their cognate receptors to initiate a variety of cellular responses. Other factors include cytokines, mitogenic factors, neurotrophic factors and the like. Extracellular domains also bind to cell-associated molecules. In this respect, they mediate cell-cell interactions. Cell-associated ligands can be tethered to the cell for example via a glycosylphosphatidylinositol (GPD) anchor, or may themselves be transmembrane proteins. Extracellular domains also associate with the extracellular matrix and contribute to the maintenance of the cell structure.


CA proteins that are transmembrane are particularly preferred in the present invention as they are good targets for immunotherapeutics, as are described herein. In addition, as outlined below, transmembrane proteins can be also useful in imaging modalities.


It will also be appreciated by those in the art that a transmembrane protein can be made soluble by removing transmembrane sequences, for example through recombinant methods. Furthermore, transmembrane proteins that have been made soluble can be made to be secreted through recombinant means by adding an appropriate signal sequence.


In a preferred embodiment, the CA proteins are secreted proteins; the secretion of which can be either constitutive or regulated. These proteins have a signal peptide or signal sequence that targets the molecule to the secretory pathway. Secreted proteins are involved in numerous physiological events; by virtue of their circulating nature, they serve to transmit signals to various other cell types. The secreted protein may function in an autocrine manner (acting on the cell that secreted the factor), a paracrine manner (acting on cells in close proximity to the cell that secreted the factor) or an endocrine manner (acting on cells at a distance). Thus secreted molecules find use in modulating or altering numerous aspects of physiology. CA proteins that are secreted proteins are particularly preferred in the present invention as they serve as good targets for diagnostic markers, for example for blood tests.


CA Sequences and Homologs


A CA sequence is initially identified by substantial nucleic acid and/or amino acid sequence homology to the CA sequences outlined herein. Such homology can be based upon the overall nucleic acid or amino acid sequence, and is generally determined as outlined below, using either homology programs or hybridization conditions.


As used herein, a nucleic acid is a “CA nucleic acid” if the overall homology of the nucleic acid sequence to one of the nucleic acids of Tables 1-7 is preferably greater than about 75%, more preferably greater than about 80%, even more preferably greater than about 85% and most preferably greater than 90%. In some embodiments the homology will be as high as about 93 to 95 or 98%. In a preferred embodiment, the sequences that are used to determine sequence identity or similarity are selected from those of the nucleic acids of Tables 1-7. In another embodiment, the sequences are naturally occurring allelic variants of the sequences of the nucleic acids of Tables 1-7. In another embodiment, the sequences are sequence variants as further described herein.


Homology in this context means sequence similarity or identity, with identity being preferred. A preferred comparison for homology purposes is to compare the sequence containing sequencing errors to the correct sequence. This homology will be determined using standard techniques known in the art, including, but not limited to, the local homology algorithm of Smith & Waterman, Adv. Appl. Math. 2:482 (1981), by the homology alignment algorithm of Needleman & Wunsch, J. Mol. Biol. 48:443 (1970), by the search for similarity method of Pearson & Lipman, PNAS USA 85:2444 (1988), by computerized implementations of these algorithms (GAP, BESTFIT, FASTA, and TFASTA in the Wisconsin Genetics Software Package, Genetics Computer Group, 575 Science Drive, Madison, Wis.), the Best Fit sequence program described by Devereux et al., Nucl. Acid Res. 12:387-395 (1984), preferably using the default settings, or by inspection.


One example of a useful algorithm is PILEUP. PILEUP creates a multiple sequence alignment from a group of related sequences using progressive, pairwise alignments. It can also plot a tree showing the clustering relationships used to create the alignment. PILEUP uses a simplification of the progressive alignment method of Feng & Doolittle, J. Mol. Evol. 35:351-360 (1987); the method is similar to that described by Higgins & Sharp CABIOS 5:151-153 (1989). Useful PILEUP parameters include a default gap weight of 3.00, a default gap length weight of 0.10, and weighted end gaps.


Another example of a useful algorithm is the BLAST (Basic Local Alignment Search Tool) algorithm, described in Altschul et al., J. Mol. Biol. 215, 403-410, (1990) and Karlin et al., PNAS USA 90:5873-5787 (1993). A particularly useful BLAST program is the WU-BLAST-2 program which was obtained from Altschul et al., Methods in Enzymology, 266: 460-480 (1996); http://blast.wustl.edu/]. WU-BLAST-2 uses several search parameters, most of which are set to the default values. The adjustable parameters are set with the following values: overlap span=1, overlap fraction=0.125, word threshold (T)=11. The HSP S and HSP S2 parameters are dynamic values and are established by the program itself depending upon the composition of the particular sequence and composition of the particular database against which the sequence of interest is being searched; however, the values may be adjusted to increase sensitivity. A percent amino acid sequence identity value is determined by the number of matching identical residues divided by the total number of residues of the “longer” sequence in the aligned region. The “longer” sequence is the one having the most actual residues in the aligned region (gaps introduced by WU-Blast-2 to maximize the alignment score are ignored).


Thus, “percent (%) nucleic acid sequence identity” is defined as the percentage of nucleotide residues in a candidate sequence that are identical with the nucleotide residues of the nucleic acids of Tables 1-7. A preferred method utilizes the BLASTN module of WU-BLAST-2 set to the default parameters, with overlap span and overlap fraction set to 1 and 0.125, respectively.


The alignment may include the introduction of gaps in the sequences to be aligned. In addition, for sequences which contain either more or fewer nucleotides than those of the nucleic acids of Tables 1-7, it is understood that the percentage of homology will be determined based on the number of homologous nucleosides in relation to the total number of nucleosides. Thus homology of sequences shorter than those of the sequences identified herein will be determined using the number of nucleosides in the shorter sequence.


In another embodiment of the invention, polynucleotide compositions are provided that are capable of hybridizing under moderate to high stringency conditions to a polynucleotide sequence provided herein, or a fragment thereof, or a complementary sequence thereof. Hybridization techniques are well known in the art of molecular biology. For purposes of illustration, suitable moderately stringent conditions for testing the hybridization of a polynucleotide of this invention with other polynucleotides include prewashing in a solution of 5×SSC (“saline sodium citrate”; 9 mM NaCl, 0.9 mM sodium citrate), 0.5% SDS, 1.0 mM EDTA (pH 8.0); hybridizing at 50-60° C., 5×SSC, overnight; followed by washing twice at 65° C. for 20 minutes with each of 2×, 0.5× and 0.2×SSC containing 0.1% SDS. One skilled in the art will understand that the stringency of hybridization can be readily manipulated, such as by altering the salt content of the hybridization solution and/or the temperature at which the hybridization is performed. For example, in another embodiment, suitable highly stringent hybridization conditions include those described above, with the exception that the temperature of hybridization is increased, e.g., to 60-65° C., or 65-70° C. Stringent conditions may also be achieved with the addition of destabilizing agents such as formamide.


Thus nucleic acids that hybridize under high stringency to the nucleic acids identified in the figures, or their complements, are considered CA sequences. High stringency conditions are known in the art; see for example Maniatis et al., Molecular Cloning: A Laboratory Manual, 2d Edition, 1989, and Short Protocols in Molecular Biology, ed. Ausubel, et al., both of which are hereby incorporated by reference. Stringent conditions are sequence-dependent and will be different in different circumstances. Longer sequences hybridize specifically at higher temperatures. An extensive guide to the hybridization of nucleic acids is found in Tijssen, Techniques in Biochemistry and Molecular Biology—Hybridization with Nucleic Acid Probes, “Overview of principles of hybridization and the strategy of nucleic acid assays” (1993). Generally, stringent conditions are selected to be about 5-10° C. lower than the thermal melting point (Tm) for the specific sequence at a defined ionic strength pH. The Tm is the temperature (under defined ionic strength, pH and nucleic acid concentration) at which 50% of the probes complementary to the target hybridize to the target sequence at equilibrium (as the target sequences are present in excess, at Tm, 50% of the probes are occupied at equilibrium). Stringent conditions will be those in which the salt concentration is less than about 1.0 M sodium ion, typically about 0.01 to 1.0 M sodium ion concentration (or other salts) at pH 7.0 to 8.3 and the temperature is at least about 30° C. for short probes (e.g. 10 to 50 nucleotides) and at least about 60° C. for longer probes (e.g. greater than 50 nucleotides). In another embodiment, less stringent hybridization conditions are used; for example, moderate or low stringency conditions may be used, as are known in the art; see Maniatis and Ausubel, supra, and Tijssen, supra.


In addition, the CA nucleic acid sequences of the invention are fragments of larger genes, i.e. they are nucleic acid segments. Alternatively, the CA nucleic acid sequences can serve as indicators of oncogene position, for example, the CA sequence may be an enhancer that activates a protooncogene. “Genes” in this context includes coding regions, non-coding regions, and mixtures of coding and non-coding regions. Accordingly, as will be appreciated by those in the art, using the sequences provided herein, additional sequences of the CA genes can be obtained, using techniques well known in the art for cloning either longer sequences or the full-length sequences; see Maniatis et al., and Ausubel, et al., supra, hereby expressly incorporated by reference. In general, this is done using PCR, for example, kinetic PCR.


Detection of CA Expression


Once the CA nucleic acid is identified, it can be cloned and, if necessary, its constituent parts recombined to form the entire CA nucleic acid. Once isolated from its natural source, e.g., contained within a plasmid or other vector or excised therefrom as a linear nucleic acid segment, the recombinant CA nucleic acid can be further used as a probe to identify and isolate other CA nucleic acids, for example additional coding regions. It can also be used as a “precursor” nucleic acid to make modified or variant CA nucleic acids and proteins. In a preferred embodiment, once a CA gene is identified its nucleotide sequence is used to design probes specific for the CA gene.


The CA nucleic acids of the present invention are used in several ways. In a first embodiment, nucleic acid probes hybridizable to CA nucleic acids are made and attached to biochips to be used in screening and diagnostic methods, or for gene therapy and/or antisense applications. Alternatively, the CA nucleic acids that include coding regions of CA proteins can be put into expression vectors for the expression of CA proteins, again either for screening purposes or for administration to a patient.


Recent developments in DNA microarray technology make it possible to conduct a large scale assay of a plurality of target CA nucleic acid molecules on a single solid phase support. U.S. Pat. No. 5,837,832 (Chee et al.) and related patent applications describe immobilizing an array of oligonucleotide probes for hybridization and detection of specific nucleic acid sequences in a sample. Target polynucleotides of interest isolated from a tissue of interest are hybridized to the DNA chip and the specific sequences detected based on the target polynucleotides' preference and degree of hybridization at discrete probe locations. One important use of arrays is in the analysis of differential gene expression, where the profile of expression of genes in different cells, often a cell of interest and a control cell, is compared and any differences in gene expression among the respective cells are identified. Such information is useful for the identification of the types of genes expressed in a particular cell or tissue type and diagnosis of cancer conditions based on the expression profile.


Typically, RNA from the sample of interest is subjected to reverse transcription to obtain labeled cDNA. See U.S. Pat. No. 6,410,229 (Lockhart et al.) The cDNA is then hybridized to oligonucleotides or cDNAs of known sequence arrayed on a chip or other surface in a known order. The location of the oligonucleotide to which the labeled cDNA hybridizes provides sequence information on the cDNA, while the amount of labeled hybridized RNA or cDNA provides an estimate of the relative representation of the RNA or cDNA of interest. See Schena, et al. Science 270:467-470 (1995). For example, use of a cDNA microarray to analyze gene expression patterns in human cancer is described by DeRisi, et al. (Nature Genetics 14:457-460 (1996)).


In a preferred embodiment, nucleic acid probes corresponding to CA nucleic acids (both the nucleic acid sequences outlined in the figures and/or the complements thereof) are made. Typically, these probes are synthesized based on the disclosed sequences of this invention. The nucleic acid probes attached to the biochip are designed to be substantially complementary to the CA nucleic acids, i.e. the target sequence (either the target sequence of the sample or to other probe sequences, for example in sandwich assays), such that specific hybridization of the target sequence and the probes of the present invention occurs. As outlined below, this complementarity need not be perfect, in that there may be any number of base pair mismatches that will interfere with hybridization between the target sequence and the single stranded nucleic acids of the present invention. It is expected that the overall homology of the genes at the nucleotide level probably will be about 40% or greater, probably about 60% or greater, and even more probably about 80% or greater; and in addition that there will be corresponding contiguous sequences of about 8-12 nucleotides or longer. However, if the number of mutations is so great that no hybridization can occur under even the least stringent of hybridization conditions, the sequence is not a complementary target sequence. Thus, by “substantially complementary” herein is meant that the probes are sufficiently complementary to the target sequences to hybridize under normal reaction conditions, particularly high stringency conditions, as outlined herein. Whether or not a sequence is unique to a CA gene according to this invention can be determined by techniques known to those of skill in the art. For example, the sequence can be compared to sequences in databanks, e.g., GeneBank, to determine whether it is present in the uninfected host or other organisms. The sequence can also be compared to the known sequences of other viral agents, including those that are known to induce cancer.


A nucleic acid probe is generally single stranded but can be partly single and partly double stranded. The strandedness of the probe is dictated by the structure, composition, and properties of the target sequence. In general, the oligonucleotide probes range from about 6, 8, 10, 12, 15, 20, 30 to about 100 bases long, with from about 10 to about 80 bases being preferred, and from about 30 to about 50 bases being particularly preferred. That is, generally entire genes are rarely used as probes. In some embodiments, much longer nucleic acids can be used, up to hundreds of bases. The probes are sufficiently specific to hybridize to complementary template sequence under conditions known by those of skill in the art. The number of mismatches between the probes sequences and their complementary template (target) sequences to which they hybridize during hybridization generally do not exceed 15%, usually do not exceed 10% and preferably do not exceed 5%, as determined by FASTA (default settings).


Oligonucleotide probes can include the naturally-occurring heterocyclic bases normally found in nucleic acids (uracil, cytosine, thymine, adenine and guanine), as well as modified bases and base analogues. Any modified base or base analogue compatible with hybridization of the probe to a target sequence is useful in the practice of the invention. The sugar or glycoside portion of the probe can comprise deoxyribose, ribose, and/or modified forms of these sugars, such as, for example, 2′-O-alkyl ribose. In a preferred embodiment, the sugar moiety is 2′-deoxyribose; however, any sugar moiety that is compatible with the ability of the probe to hybridize to a target sequence can be used.


In one embodiment, the nucleoside units of the probe are linked by a phosphodiester backbone, as is well known in the art. In additional embodiments, internucleotide linkages can include any linkage known to one of skill in the art that is compatible with specific hybridization of the probe including, but not limited to phosphorothioate, methylphosphonate, sulfamate (e.g., U.S. Pat. No. 5,470,967) and polyamide (i.e., peptide nucleic acids). Peptide nucleic acids are described in Nielsen et al. (1991) Science 254: 1497-1500, U.S. Pat. No. 5,714,331, and Nielsen (1999) Curr. Opin. Biotechnol. 10:71-75.


In certain embodiments, the probe can be a chimeric molecule; i.e., can comprise more than one type of base or sugar subunit, and/or the linkages can be of more than one type within the same primer. The probe can comprise a moiety to facilitate hybridization to its target sequence, as are known in the art, for example, intercalators and/or minor groove binders. Variations of the bases, sugars, and internucleoside backbone, as well as the presence of any pendant group on the probe, will be compatible with the ability of the probe to bind, in a sequence-specific fashion, with its target sequence. A large number of structural modifications, both known and to be developed, are possible within these bounds. Advantageously, the probes according to the present invention may have structural characteristics such that they allow the signal amplification, such structural characteristics being, for example, branched DNA probes as those described by Urdea et al. (Nucleic Acids Symp. Ser., 24:197-200 (1991)) or in the European Patent No. EP-0225,807. Moreover, synthetic methods for preparing the various heterocyclic bases, sugars, nucleosides and nucleotides that form the probe, and preparation of oligonucleotides of specific predetermined sequence, are well-developed and known in the art. A preferred method for oligonucleotide synthesis incorporates the teaching of U.S. Pat. No. 5,419,966.


Multiple probes may be designed for a particular target nucleic acid to account for polymorphism and/or secondary structure in the target nucleic acid, redundancy of data and the like. In some embodiments, where more than one probe per sequence is used, either overlapping probes or probes to different sections of a single target CA gene are used. That is, two, three, four or more probes, with three being preferred, are used to build in a redundancy for a particular target. The probes can be overlapping (i.e. have some sequence in common), or specific for distinct sequences of a CA gene. When multiple target polynucleotides are to be detected according to the present invention, each probe or probe group corresponding to a particular target polynucleotide is situated in a discrete area of the microarray.


Probes may be in solution, such as in wells or on the surface of a micro-array, or attached to a solid support. Examples of solid support materials that can be used include a plastic, a ceramic, a metal, a resin, a gel and a membrane. Useful types of solid supports include plates, beads, magnetic material, microbeads, hybridization chips, membranes, crystals, ceramics and self-assembling monolayers. A preferred embodiment comprises a two-dimensional or three-dimensional matrix, such as a gel or hybridization chip with multiple probe binding sites (Pevzner et al., J. Biomol. Struc. & Dyn. 9:399-410, 1991; Maskos and Southern, Nuc. Acids Res. 20:1679-84, 1992). Hybridization chips can be used to construct very large probe arrays that are subsequently hybridized with a target nucleic acid. Analysis of the hybridization pattern of the chip can assist in the identification of the target nucleotide sequence. Patterns can be manually or computer analyzed, but it is clear that positional sequencing by hybridization lends itself to computer analysis and automation. Algorithms and software, which have been developed for sequence reconstruction, are applicable to the methods described herein (R. Drmanac et al., J. Biomol. Struc. & Dyn. 5:1085-1102, 1991; P. A. Pevzner, J. Biomol. Struc. & Dyn. 7:63-73, 1989).


As will be appreciated by those in the art, nucleic acids can be attached or immobilized to a solid support in a wide variety of ways. By “immobilized” herein is meant the association or binding between the nucleic acid probe and the solid support is sufficient to be stable under the conditions of binding, washing, analysis, and removal as outlined below. The binding can be covalent or non-covalent. By “non-covalent binding” and grammatical equivalents herein is meant one or more of either electrostatic, hydrophilic, and hydrophobic interactions. Included in non-covalent binding is the covalent attachment of a molecule, such as streptavidin, to the support and the non-covalent binding of the biotinylated probe to the streptavidin. By “covalent binding” and grammatical equivalents herein is meant that the two moieties, the solid support and the probe, are attached by at least one bond, including sigma bonds, pi bonds and coordination bonds. Covalent bonds can be formed directly between the probe and the solid support or can be formed by a cross linker or by inclusion of a specific reactive group on either the solid support or the probe or both molecules. Immobilization may also involve a combination of covalent and non-covalent interactions.


Nucleic acid probes may be attached to the solid support by covalent binding such as by conjugation with a coupling agent or by, covalent or non-covalent binding such as electrostatic interactions, hydrogen bonds or antibody-antigen coupling, or by combinations thereof. Typical coupling agents include biotin/avidin, biotin/streptavidin, Staphylococcus aureus protein A/IgG antibody F, fragment, and streptavidin/protein A chimeras (T. Sano and C. R. Cantor, Bio/Technology 9:1378-81 (1991)), or derivatives or combinations of these agents. Nucleic acids may be attached to the solid support by a photocleavable bond, an electrostatic bond, a disulfide bond, a peptide bond, a diester bond or a combination of these sorts of bonds. The array may also be attached to the solid support by a selectively releasable bond such as 4,4′-dimethoxytrityl or its derivative. Derivatives which have been found to be useful include 3 or 4 [bis-(4-methoxyphenyl)]-methyl-benzoic acid, N-succinimidyl-3 or 4 [bis-(4-methoxyphenyl)]-methyl-benzoic acid, N-succinimidyl-3 or 4 [bis-(4-methoxyphenyl)]-hydroxymethyl-benzoic acid, N-succinimidyl-3 or 4 [bis-(4-methoxyphenyl)]-chloromethyl-benzoic acid, and salts of these acids.


In general, the probes are attached to the biochip in a wide variety of ways, as will be appreciated by those in the art. As described herein, the nucleic acids can either be synthesized first, with subsequent attachment to the biochip, or can be directly synthesized on the biochip.


The biochip comprises a suitable solid substrate. By “substrate” or “solid support” or other grammatical equivalents herein is meant any material that can be modified to contain discrete individual sites appropriate for the attachment or association of the nucleic acid probes and is amenable to at least one detection method. The solid phase support of the present invention can be of any solid materials and structures suitable for supporting nucleotide hybridization and synthesis. Preferably, the solid phase support comprises at least one substantially rigid surface on which the primers can be immobilized and the reverse transcriptase reaction performed. The substrates with which the polynucleotide microarray elements are stably associated may be fabricated from a variety of materials, including plastics, ceramics, metals, acrylamide, cellulose, nitrocellulose, glass, polystyrene, polyethylene vinyl acetate, polypropylene, polymethacrylate, polyethylene, polyethylene oxide, polysilicates, polycarbonates, Teflon®, fluorocarbons, nylon, silicon rubber, polyanhydrides, polyglycolic acid, polylactic acid, polyorthoesters, polypropylfumerate, collagen, glycosaminoglycans, and polyamino acids. Substrates may be two-dimensional or three-dimensional in form, such as gels, membranes, thin films, glasses, plates, cylinders, beads, magnetic beads, optical fibers, woven fibers, etc. A preferred form of array is a three-dimensional array. A preferred three-dimensional array is a collection of tagged beads. Each tagged bead has different primers attached to it. Tags are detectable by signaling means such as color (Luminex, Illumina) and electromagnetic field (Pharmaseq) and signals on tagged beads can even be remotely detected (e.g., using optical fibers). The size of the solid support can be any of the standard microarray sizes, useful for DNA microarray technology, and the size may be tailored to fit the particular machine being used to conduct a reaction of the invention. In general, the substrates allow optical detection and do not appreciably fluoresce.


In a preferred embodiment, the surface of the biochip and the probe may be derivatized with chemical functional groups for subsequent attachment of the two. Thus, for example, the biochip is derivatized with a chemical functional group including, but not limited to, amino groups, carboxy groups, oxo groups and thiol groups, with amino groups being particularly preferred. Using these functional groups, the probes can be attached using functional groups on the probes. For example, nucleic acids containing amino groups can be attached to surfaces comprising amino groups, for example using linkers as are known in the art; for example, homo- or hetero-bifunctional linkers as are well known (see 1994 Pierce Chemical Company catalog, technical section on cross-linkers, pages 155-200, incorporated herein by reference). In addition, in some cases, additional linkers, such as alkyl groups (including substituted and heteroalkyl groups) may be used.


In this embodiment, the oligonucleotides are synthesized as is known in the art, and then attached to the surface of the solid support. As will be appreciated by those skilled in the art, either the 5′ or 3′ terminus may be attached to the solid support, or attachment may be via an internal nucleoside. In an additional embodiment, the immobilization to the solid support may be very strong, yet non-covalent. For example, biotinylated oligonucleotides can be made, which bind to surfaces covalently coated with streptavidin, resulting in attachment.


The arrays may be produced according to any convenient methodology, such as preforming the polynucleotide microarray elements and then stably associating them with the surface. Alternatively, the oligonucleotides may be synthesized on the surface, as is known in the art. A number of different array configurations and methods for their production are known to those of skill in the art and disclosed in WO 95/25116 and WO 95/35505 (photolithographic techniques), U.S. Pat. No. 5,445,934 (in situ synthesis by photolithography), U.S. Pat. No. 5,384,261 (in situ synthesis by mechanically directed flow paths); and U.S. Pat. No. 5,700,637 (synthesis by spotting, printing or coupling); the disclosure of which are herein incorporated in their entirety by reference. Another method for coupling DNA to beads uses specific ligands attached to the end of the DNA to link to ligand-binding molecules attached to a bead. Possible ligand-binding partner pairs include biotin-avidin/streptavidin, or various antibody/antigen pairs such as digoxygenin-antidigoxygenin antibody (Smith et al., “Direct Mechanical Measurements of the Elasticity of Single DNA Molecules by Using Magnetic Beads,” Science 258:1122-1126 (1992)). Covalent chemical attachment of DNA to the support can be accomplished by using standard coupling agents to link the 5′-phosphate on the DNA to coated microspheres through a phosphoamidate bond. Methods for immobilization of oligonucleotides to solid-state substrates are well established. See Pease et al., Proc. Natl. Acad. Sci. USA 91(11):5022-5026 (1994). A preferred method of attaching oligonucleotides to solid-state substrates is described by Guo et al., Nucleic Acids Res. 22:5456-5465 (1994). Immobilization can be accomplished either by in situ DNA synthesis (Maskos and Southern, Nucleic Acids Research, 20:1679-1684 (1992) or by covalent attachment of chemically synthesized oligonucleotides (Guo et al., supra) in combination with robotic arraying technologies.


In addition to the solid-phase technology represented by biochip arrays, gene expression can also be quantified using liquid-phase arrays. One such system is kinetic polymerase chain reaction (PCR). Kinetic PCR allows for the simultaneous amplification and quantification of specific nucleic acid sequences. The specificity is derived from synthetic oligonucleotide primers designed to preferentially adhere to single-stranded nucleic acid sequences bracketing the target site. This pair of oligonucleotide primers form specific, non-covalently bound complexes on each strand of the target sequence. These complexes facilitate in vitro transcription of double-stranded DNA in opposite orientations. Temperature cycling of the reaction mixture creates a continuous cycle of primer binding, transcription, and re-melting of the nucleic acid to individual strands. The result is an exponential increase of the target dsDNA product. This product can be quantified in real time either through the use of an intercalating dye or a sequence specific probe. SYBR® Greene I, is an example of an intercalating dye, that preferentially binds to dsDNA resulting in a concomitant increase in the fluorescent signal. Sequence specific probes, such as used with TaqMang technology, consist of a fluorochrome and a quenching molecule covalently bound to opposite ends of an oligonucleotide. The probe is designed to selectively bind the target DNA sequence between the two primers. When the DNA strands are synthesized during the PCR reaction, the fluorochrome is cleaved from the probe by the exonuclease activity of the polymerase resulting in signal dequenching. The probe signaling method can be more specific than the intercalating dye method, but in each case, signal strength is proportional to the dsDNA product produced. Each type of quantification method can be used in multi-well liquid phase arrays with each well representing primers and/or probes specific to nucleic acid sequences of interest. When used with messenger RNA preparations of tissues or cell lines, an array of probe/primer reactions can simultaneously quantify the expression of multiple gene products of interest. See Germer, S., et al., Genome Res. 10:258-266 (2000); Heid, C. A., et al., Genome Res. 6, 986-994 (1996).


Expression of CA Proteins


In a preferred embodiment, CA nucleic acids encoding CA proteins are used to make a variety of expression vectors to express CA proteins which can then be used in screening assays, as described below. The expression vectors may be either self-replicating extrachromosomal vectors or vectors which integrate into a host genome. Generally, these expression vectors include transcriptional and translational regulatory nucleic acid operably linked to the nucleic acid encoding the CA protein. The term “control sequences” refers to DNA sequences necessary for the expression of an operably linked coding sequence in a particular host organism. The control sequences that are suitable for prokaryotes, for example, include a promoter, optionally an operator sequence, and a ribosome binding site. Eukaryotic cells are known to utilize promoters, polyadenylation signals, and enhancers.


Nucleic acid is “operably linked” when it is placed into a functional relationship with another nucleic acid sequence. For example, DNA for a presequence or secretory leader is operably linked to DNA for a polypeptide if it is expressed as a preprotein that participates in the secretion of the polypeptide; a promoter or enhancer is operably linked to a coding sequence if it affects the transcription of the sequence; or a ribosome binding site is operably linked to a coding sequence if it is positioned so as to facilitate translation. Generally, “operably linked” means that the DNA sequences being linked are contiguous, and, in the case of a secretory leader, contiguous and in reading phase. However, enhancers do not have to be contiguous. Linking is accomplished by ligation at convenient restriction sites. If such sites do not exist, synthetic oligonucleotide adaptors or linkers are used in accordance with conventional practice. The transcriptional and translational regulatory nucleic acid will generally be appropriate to the host cell used to express the CA protein; for example, transcriptional and translational regulatory nucleic acid sequences from Bacillus are preferably used to express the CA protein in Bacillus. Numerous types of appropriate expression vectors, and suitable regulatory sequences are known in the art for a variety of host cells.


In general, the transcriptional and translational regulatory sequences may include, but are not limited to, promoter sequences, ribosomal binding sites, transcriptional start and stop sequences, translational start and stop sequences, and enhancer or activator sequences. In a preferred embodiment, the regulatory sequences include a promoter and transcriptional start and stop sequences.


Promoter sequences encode either constitutive or inducible promoters. The promoters may be either naturally occurring promoters or hybrid promoters. Hybrid promoters, which combine elements of more than one promoter, are also known in the art, and are useful in the present invention.


In addition, the expression vector may comprise additional elements. For example, the expression vector may have two replication systems, thus allowing it to be maintained in two organisms, for example in mammalian or insect cells for expression and in a prokaryotic host for cloning and amplification. Furthermore, for integrating expression vectors, the expression vector contains at least one sequence homologous to the host cell genome, and preferably two homologous sequences that flank the expression construct. The integrating vector may be directed to a specific locus in the host cell by selecting the appropriate homologous sequence for inclusion in the vector. Constructs for integrating vectors are well known in the art.


In addition, in a preferred embodiment, the expression vector contains a selectable marker gene to allow the selection of transformed host cells. Selection genes are well known in the art and will vary with the host cell used.


The CA proteins of the present invention are produced by culturing a host cell transformed with an expression vector containing nucleic acid encoding a CA protein, under the appropriate conditions to induce or cause expression of the CA protein. The conditions appropriate for CA protein expression will vary with the choice of the expression vector and the host cell, and will be easily ascertained by one skilled in the art through routine experimentation. For example, the use of constitutive promoters in the expression vector will require optimizing the growth and proliferation of the host cell, while the use of an inducible promoter requires the appropriate growth conditions for induction. In addition, in some embodiments, the timing of the harvest is important. For example, the baculoviral systems used in insect cell expression are lytic viruses, and thus harvest time selection can be crucial for product yield.


Appropriate host cells include yeast, bacteria, archaebacteria, fungi, and insect, plant and animal cells, including mammalian cells. Of particular interest are Drosophila melanogaster cells, Saccharomyces cerevisiae and other yeasts, E. coli, Bacillus subtilis, Sf9 cells, C129 cells, 293 cells, Neurospora, BHK, CHO, COS, HeLa cells, THP1 cell line (a macrophage cell line) and human cells and cell lines.


In a preferred embodiment, the CA proteins are expressed in mammalian cells. Mammalian expression systems are also known in the art, and include retroviral systems. A preferred expression vector system is a retroviral vector system such as is generally described in PCT/US97/01019 and PCT/US97/01048, both of which are hereby expressly incorporated by reference. Of particular use as mammalian promoters are the promoters from mammalian viral genes, since the viral genes are often highly expressed and have a broad host range. Examples include the SV40 early promoter, mouse mammary tumor virus LTR promoter, adenovirus major late promoter, herpes simplex virus promoter, and the CMV promoter. Typically, transcription termination and polyadenylation sequences recognized by mammalian cells are regulatory regions located 3′ to the translation stop codon and thus, together with the promoter elements, flank the coding sequence. Examples of transcription terminator and polyadenylation signals include those derived form SV40.


The methods of introducing exogenous nucleic acid into mammalian hosts, as well as other hosts, are well known in the art, and will vary with the host cell used. Techniques include dextran-mediated transfection, calcium phosphate precipitation, polybrene mediated transfection, protoplast fusion, electroporation, viral infection, encapsulation of the polynucleotide(s) in liposomes, and direct microinjection of the DNA into nuclei.


In a preferred embodiment, CA proteins are expressed in bacterial systems. Bacterial expression systems are well known in the art. Promoters from bacteriophage may also be used and are known in the art. In addition, synthetic promoters and hybrid promoters are also useful; for example, the tac promoter is a hybrid of the trp and lac promoter sequences. Furthermore, a bacterial promoter can include naturally occurring promoters of non-bacterial origin that have the ability to bind bacterial RNA polymerase and initiate transcription. In addition to a functioning promoter sequence, an efficient ribosome binding site is desirable. The expression vector may also include a signal peptide sequence that provides for secretion of the CA protein in bacteria. The protein is either secreted into the growth media (gram-positive bacteria) or into the periplasmic space, located between the inner and outer membrane of the cell (gram-negative bacteria). The bacterial expression vector may also include a selectable marker gene to allow for the selection of bacterial strains that have been transformed. Suitable selection genes include genes that render the bacteria resistant to drugs such as ampicillin, chloramphenicol, erythromycin, kanamycin, neomycin and tetracycline. Selectable markers also include biosynthetic genes, such as those in the histidine, tryptophan and leucine biosynthetic pathways. These components are assembled into expression vectors. Expression vectors for bacteria are well known in the art, and include vectors for Bacillus subtilis, E. coli, Streptococcus cremoris, and Streptococcus lividans, among others. The bacterial expression vectors are transformed into bacterial host cells using techniques well known in the art, such as calcium chloride treatment, electroporation, and others.


In one embodiment, CA proteins are produced in insect cells. Expression vectors for the transformation of insect cells, and in particular, baculovirus-based expression vectors, are well known in the art.


In a preferred embodiment, CA protein is produced in yeast cells. Yeast expression systems are well known in the art, and include expression vectors for Saccharomyces cerevisiae, Candida albicans and C. maltosa, Hansenula polymorpha, Kluyveromyces fragilis and K lactis, Pichia guillerimondii and P. pastoris, Schizosaccharomyces pombe, and Yarrowia lipolytica.


The CA protein may also be made as a fusion protein, using techniques well known in the art. Thus, for example, for the creation of monoclonal antibodies. If the desired epitope is small, the CA protein may be fused to a carrier protein to form an immunogen. Alternatively, the CA protein may be made as a fusion protein to increase expression, or for other reasons. For example, when the CA protein is a CA peptide, the nucleic acid encoding the peptide may be linked to other nucleic acid for expression purposes.


In one embodiment, the CA nucleic acids, proteins and antibodies of the invention are labeled. By “labeled” herein is meant that a compound has at least one element, isotope or chemical compound attached to enable the detection of the compound. In general, labels fall into three classes: a) isotopic labels, which may be radioactive or heavy isotopes; b) immune labels, which may be antibodies or antigens; and c) colored or fluorescent dyes. The labels may be incorporated into the CA nucleic acids, proteins and antibodies at any position. For example, the label should be capable of producing, either directly or indirectly, a detectable signal. The detectable moiety may be a radioisotope, such as 3H, 14C, 32P, 35S, or 125I, a fluorescent or chemiluminescent compound, such as fluorescein isothiocyanate, rhodamine, or luciferin, or an enzyme, such as alkaline phosphatase, beta-galactosidase or horseradish peroxidase. Any method known in the art for conjugating the antibody to the label may be employed, including those methods described by Hunter et al., Nature, 144:945 (1962); David et al., Biochemistry, 13:1014 (1974); Pain et al., J. Immunol. Meth., 40:219 (1981); and Nygren, J. Histochem. and Cytochem., 30:407 (1982).


Accordingly, the present invention also provides CA protein sequences. A CA protein of the present invention may be identified in several ways. “Protein” in this sense includes proteins, polypeptides, and peptides. As will be appreciated by those in the art, the nucleic acid sequences of the invention can be used to generate protein sequences. There are a variety of ways to do this, including cloning the entire gene and verifying its frame and amino acid sequence, or by comparing it to known sequences to search for homology to provide a frame, assuming the CA protein has homology to some protein in the database being used. Generally, the nucleic acid sequences are input into a program that will search all three frames for homology. This is done in a preferred embodiment using the following NCBI Advanced BLAST parameters. The program is blastx or blastn. The database is nr. The input data is as “Sequence in FASTA format”. The organism list is “none”. The “expect” is 10; the filter is default. The “descriptions” is 500, the “alignments” is 500, and the “alignment view” is pairwise. The “query Genetic Codes” is standard (1). The matrix is BLOSUM 62; gap existence cost is 11, per residue gap cost is 1; and the lambda ratio is 0.85 default. This results in the generation of a putative protein sequence.


In general, the term “polypeptide” as used herein refers to both the full-length polypeptide encoded by the recited polynucleotide, the polypeptide encoded by the gene represented by the recited polynucleotide, as well as portions or fragments thereof. The present invention encompasses variants of the naturally occurring proteins, wherein such variants are homologous or substantially similar to the naturally occurring protein, and can be of an origin of the same or different species as the naturally occurring protein (e.g., human, murine, or some other species that naturally expresses the recited polypeptide, usually a mammalian species). In general, variant polypeptides have a sequence that has at least about 80%, at least about 81%, at least about 82%, at least about 83%, at least about 84%, at least about 85%, at least about 86%, at least about 87%, at least about 88%, at least about 89%, usually at least about 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98% and more usually at least about 99% sequence identity with a differentially expressed polypeptide described herein, as determined by the Smith-Waterman homology search algorithm using an affine gap search with a gap open penalty of 12 and a gap extension penalty of 2, BLOSUM matrix of 62. The Smith-Waterman homology search algorithm is taught in Smith and Waterman, Adv. Appl. Math. (1981) 2: 482-489. The variant polypeptides can be naturally or non-naturally glycosylated, i.e., the polypeptide has a glycosylation pattern that differs from the glycosylation pattern found in the corresponding naturally occurring protein.


Also within the scope of the invention are variants. Variants of polypeptides include mutants, fragments, and fusions. Mutants can include amino acid substitutions, additions or deletions. The amino acid substitutions can be conservative amino acid substitutions or substitutions to eliminate non-essential amino acids, such as to alter a glycosylation site, a phosphorylation site or an acetylation site, or to minimize misfolding by substitution or deletion of one or more cysteine residues that are not necessary for function. Conservative amino acid substitutions are those that preserve the general charge, hydrophobicity/hydrophilicity, and/or steric bulk of the amino acid substituted. Variants can be designed so as to retain or have enhanced biological activity of a particular region of the protein (e.g., a functional domain and/or, where the polypeptide is a member of a protein family, a region associated with a consensus sequence). Selection of amino acid alterations for production of variants can be based upon the accessibility (interior vs. exterior) of the amino acid (see, e.g., Go et al, Int. J. Peptide Protein Res. (1980) 15:211), the thermostability of the variant polypeptide (see, e.g., Querol et al., Prot. Eng. (1996) 9:265), desired glycosylation sites (see, e.g., Olsen and Thomsen, J. Gen. Microbiol. (1991) 137:579), desired disulfide bridges (see, e.g., Clarke et al., Biochemistry (1993) 32:4322; and Wakarchuk et al., Protein Eng. (1994) 7:1379), desired metal binding sites (see, e.g., Toma et al., Biochemistry (1991) 30:97, and Haezerbrouck et al., Protein Eng. (1993) 6:643), and desired substitutions within proline loops (see, e.g., Masul et al., Appl. Env. Microbiol. (1994) 60:3579). Cysteine-depleted muteins can be produced as disclosed in U.S. Pat. No. 4,959,314.


Variants also include fragments of the polypeptides disclosed herein, particularly biologically active fragments and/or fragments corresponding to functional domains. Fragments of interest will typically be at least about 8 amino acids (aa) 10 aa, 15 aa, 20 aa, 25 aa, 30 aa, 35 aa, 40 aa, to at least about 45 aa in length, usually at least about 50 aa in length, at least about 75 aa, at least about 100 aa, at least about 125 aa, at least about 150 aa in length, at least about 200 aa, at least about 300 aa, at least about 400 aa and can be as long as 500 aa in length or longer, but will usually not exceed about 1000 aa in length, where the fragment will have a stretch of amino acids that is identical to a polypeptide encoded by a polynucleotide having a sequence of any one of the polynucleotide sequences provided herein, or a homolog thereof. The protein variants described herein are encoded by polynucleotides that are within the scope of the invention. The genetic code can be used to select the appropriate codons to construct the corresponding variants.


While altered expression of the polynucleotides associated with cancer is observed, altered levels of expression of the polypeptides encoded by these polynucleotides may likely play a role in cancers.


Also included within one embodiment of CA proteins are amino acid variants of the naturally occurring sequences, as determined herein. Preferably, the variants are preferably greater than about 75% homologous to the wild-type sequence, more preferably greater than about 80%, even more preferably greater than about 85% and most preferably greater than 90%. The present application is also directed to proteins containing polypeptides at least 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% identical to a CA polypeptide sequence set forth herein. As for nucleic acids, homology in this context means sequence similarity or identity, with identity being preferred. This homology will be determined using standard techniques known in the art as are outlined above for the nucleic acid homologies.


CA proteins of the present invention may be shorter or longer than the wild type amino acid sequences. Thus, in a preferred embodiment, included within the definition of CA proteins are portions or fragments of the wild type sequences herein. In addition, as outlined above, the CA nucleic acids of the invention may be used to obtain additional coding regions, and thus additional protein sequence, using techniques known in the art.


In a preferred embodiment, the CA proteins are derivative or variant CA proteins as compared to the wild-type sequence. That is, as outlined more fully below, the derivative CA peptide will contain at least one amino acid substitution, deletion or insertion, with amino acid substitutions being particularly preferred. The amino acid substitution, insertion or deletion may occur at any residue within the CA peptide.


Also included in an embodiment of CA proteins of the present invention are amino acid sequence variants. These variants fall into one or more of three classes: substitutional, insertional or deletional variants. These variants ordinarily are prepared by site-specific mutagenesis of nucleotides in the DNA encoding the CA protein, using cassette or PCR mutagenesis or other techniques well known in the art, to produce DNA encoding the variant, and thereafter expressing the DNA in recombinant cell culture as outlined above. However, variant CA protein fragments having up to about 100-150 residues may be prepared by in vitro synthesis using established techniques. Amino acid sequence variants are characterized by the predetermined nature of the variation, a feature that sets them apart from naturally occurring allelic or interspecies variation of the CA protein amino acid sequence. The variants typically exhibit the same qualitative biological activity as the naturally occurring analogue, although variants can also be selected which have modified characteristics as will be more fully outlined below.


While the site or region for introducing an amino acid sequence variation is predetermined, the mutation per se need not be predetermined. For example, in order to optimize the performance of a mutation at a given site, random mutagenesis may be conducted at the target codon or region and the expressed CA variants screened for the optimal combination of desired activity. Techniques for making substitution mutations at predetermined sites in DNA having a known sequence are well known, for example, M13 primer mutagenesis and LAR mutagenesis. Screening of the mutants is done using assays of CA protein activities.


Amino acid substitutions are typically of single residues; insertions usually will be on the order of from about 1 to 20 amino acids, although considerably larger insertions may be tolerated. Deletions range from about 1 to about 20 residues, although in some cases deletions may be much larger.


Substitutions, deletions, insertions or any combination thereof may be used to arrive at a final derivative. Generally these changes are done on a few amino acids to minimize the alteration of the molecule. However, larger changes may be tolerated in certain circumstances. When small alterations in the characteristics of the CA protein are desired, substitutions are generally made in accordance with the following chart:

CHART 1OriginalExemplaryResidueSubstitutionsAlaSerArgLysAsnGln, HisAspGluCysSerGlnAsnGluAspGlyProHisAsn, GlnIleLeu, ValLeuIle, ValLysArg, Gln, GluMetLeu, IlePheMet, Leu, TyrSerThrThrSerTrpTyrTyrTrp, PheValIle, Leu


Substantial changes in function or immunological identity are made by selecting substitutions that are less conservative than those shown in Chart I. For example, substitutions may be made full length to more significantly affect one or more of the following: the structure of the polypeptide backbone in the area of the alteration (e.g., the alpha-helical or beta-sheet structure); the charge or hydrophobicity of the molecule at the target site; and the bulk of the side chain. The substitutions which in general are expected to produce the greatest changes in the polypeptide's properties are those in which (a) a hydrophilic residue, e.g. seryl or threonyl is substituted for (or by) a hydrophobic residue, e.g. leucyl, isoleucyl, phenylalanyl, valyl or alanyl; (b) a cysteine or proline is substituted for (or by) any other residue; (c) a residue having an electropositive side chain, e.g. lysyl, arginyl, or histidyl, is substituted for (or by) an electronegative residue, e.g. glutamyl or aspartyl; or (d) a residue having a bulky side chain, e.g. phenylalanine, is substituted for (or by) one not having a side chain, e.g. glycine.


The variants typically exhibit the same qualitative biological activity and will elicit the same immune response as the naturally-occurring analogue, although variants also are selected to modify the characteristics of the CA proteins as needed. Alternatively, the variant may be designed such that the biological activity of the CA protein is altered. For example, glycosylation sites may be altered or removed, dominant negative mutations created, etc.


Covalent modifications of CA polypeptides are included within the scope of this invention, for example for use in screening. One type of covalent modification includes reacting targeted amino acid residues of a CA polypeptide with an organic derivatizing agent that is capable of reacting with selected side chains or the N- or C-terminal residues of a CA polypeptide. Derivatization with bifunctional agents is useful, for instance, for crosslinking CA polypeptides to a water-insoluble support matrix or surface for use in the method for purifying anti-CA antibodies or screening assays, as is more fully described below. Commonly used crosslinking agents include, e.g., 1,1-bis(diazoacetyl)-2-phenylethane, glutaraldehyde, N-hydroxysuccinimide esters, for example, esters with 4-azidosalicylic acid, homobifunctional imidoesters, including disuccinimidyl esters such as 3,3′-dithiobis(succinimidylpropionate), bifunctional maleimides such as bis-N-maleimido-1,8-octane and agents such as methyl-3-[(p-azidophenyl)dithio]propioimidate.


Other modifications include deamidation of glutaminyl and asparaginyl residues to the corresponding glutamyl and aspartyl residues, respectively, hydroxylation of proline and lysine, phosphorylation of hydroxyl groups of seryl, threonyl or tyrosyl residues, methylation of the a-amino groups of lysine, arginine, and histidine side chains [T. E. Creighton, Proteins: Structure and Molecular Properties, W.H. Freeman & Co., San Francisco, pp. 79-86 (1983)], acetylation of the N-terminal amine, and amidation of any C-terminal carboxyl group.


Another type of covalent modification of the CA polypeptide included within the scope of this invention comprises altering the native glycosylation pattern of the polypeptide. “Altering the native glycosylation pattern” is intended for purposes herein to mean deleting one or more carbohydrate moieties found in native sequence CA polypeptide, and/or adding one or more glycosylation sites that are not present in the native sequence CA polypeptide.


Addition of glycosylation sites to CA polypeptides may be accomplished by altering the amino acid sequence thereof. The alteration may be made, for example, by the addition of, or substitution by, one or more serine or threonine residues to the native sequence CA polypeptide (for O-linked glycosylation sites). The CA amino acid sequence may optionally be altered through changes at the DNA level, particularly by mutating the DNA encoding the CA polypeptide at preselected bases such that codons are generated that will translate into the desired amino acids.


Another means of increasing the number of carbohydrate moieties on the CA polypeptide is by chemical or enzymatic coupling of glycosides to the polypeptide. Such methods are described in the art, e.g., in WO 87/05330 published 11 Sep. 1987, and in Aplin and Wriston, L A Crit. Rev. Biochem., pp. 259-306 (1981).


Removal of carbohydrate moieties present on the CA polypeptide may be accomplished chemically or enzymatically or by mutational substitution of codons encoding for amino acid residues that serve as targets for glycosylation. Chemical deglycosylation techniques are known in the art and described, for instance, by Hakimuddin, et al., Arch. Biochem. Biophys., 259:52 (1987) and by Edge et al., Anal. Biochem., 118:131 (1981). Enzymatic cleavage of carbohydrate moieties on polypeptides can be achieved by the use of a variety of endo- and exo-glycosidases as described by Thotakura et al., Meth. Enzymol., 138:350 (1987).


Another type of covalent modification of CA comprises linking the CA polypeptide to one of a variety of nonproteinaceous polymers, e.g., polyethylene glycol, polypropylene glycol, or polyoxyalkylenes, in the manner set forth in U.S. Pat. No. 4,640,835; 4,496,689; 4,301,144; 4,670,417; 4,791,192 or 4,179,337.


CA polypeptides of the present invention may also be modified in a way to form chimeric molecules comprising a CA polypeptide fused to another, heterologous polypeptide or amino acid sequence. In one embodiment, such a chimeric molecule comprises a fusion of a CA polypeptide with a tag polypeptide that provides an epitope to which an anti-tag antibody can selectively bind. The epitope tag is generally placed at the amino- or carboxyl-terminus of the CA polypeptide, although internal fusions may also be tolerated in some instances. The presence of such epitope-tagged forms of a CA polypeptide can be detected using an antibody against the tag polypeptide. Also, provision of the epitope tag enables the CA polypeptide to be readily purified by affinity purification using an anti-tag antibody or another type of affinity matrix that binds to the epitope tag. In an alternative embodiment, the chimeric molecule may comprise a fusion of a CA polypeptide with an immunoglobulin or a particular region of an immunoglobulin. For a bivalent form of the chimeric molecule, such a fusion could be to the Fc region of an IgG molecule.


Various tag polypeptides and their respective antibodies are well known in the art. Examples include poly-histidine (poly-his) or poly-histidine-glycine (poly-his-gly) tags; the flu HA tag polypeptide and its antibody 12CA5 [Field et al., Mol. Cell. Biol., 8:2159-2165 (1988)]; the c-myc tag and the 8F9, 3C7, 6E10, G4, B7 and 9E10 antibodies thereto [Evan et al., Molecular and Cellular Biology, 5:3610-3616 (1985)]; and the Herpes Simplex virus glycoprotein D (gD) tag and its antibody [Paborsky et al., Protein Engineering, 3(6):547-553 (1990)]. Other tag polypeptides include the Flag-peptide [Hopp et al., BioTechnology, 6:1204-1210 (1988)]; the KT3 epitope peptide [Martin et al., Science, 255:192-194 (1992)]; tubulin epitope peptide [Skinner et al., J. Biol. Chem., 266:15163-15166 (1991)]; and the T7 gene 10 protein peptide tag [Lutz-Freyermuth et al., Proc. Natl. Acad. Sci. USA, 87:6393-6397 (1990)].


Also included with the definition of CA protein in one embodiment are other CA proteins of the CA family, and CA proteins from other organisms, which are cloned and expressed as outlined below. Thus, probe or degenerate polymerase chain reaction (PCR) primer sequences may be used to find other related CA proteins from humans or other organisms. As will be appreciated by those in the art, particularly useful probe and/or PCR primer sequences include the unique areas of the CA nucleic acid sequence. As is generally known in the art, preferred PCR primers are from about 15 to about 35 nucleotides in length, with from about 20 to about 30 being preferred, and may contain inosine as needed. The conditions for the PCR reaction are well known in the art.


In addition, as is outlined herein, CA proteins can be made that are longer than those encoded by the nucleic acids of the figures, for example, by the elucidation of additional sequences, the addition of epitope or purification tags, the addition of other fusion sequences, etc.


CA proteins may also be identified as being encoded by CA nucleic acids. Thus, CA proteins are encoded by nucleic acids that will hybridize to the sequences of the sequence listings, or their complements, as outlined herein.


CA Antigens and Antibodies Thereto


In one embodiment, the invention provides CA specific antibodies. In a preferred embodiment, when the CA protein is to be used to generate antibodies, for example for immunotherapy, the CA protein should share at least one epitope or determinant with the full-length protein. By “epitope” or “determinant” herein is meant a portion of a protein that will generate and/or bind an antibody or T-cell receptor in the context of MHC. Thus, in most instances, antibodies made to a smaller CA protein will be able to bind to the full-length protein. In a preferred embodiment, the epitope is unique; that is, antibodies generated to a unique epitope show little or no cross-reactivity.


Any polypeptide sequence encoded by the CA polynucleotide sequences may be analyzed to determine certain preferred regions of the polypeptide. Regions of high antigenicity are determined from data by DNASTAR analysis by choosing values that represent regions of the polypeptide that are likely to be exposed on the surface of the polypeptide in an environment in which antigen recognition may occur in the process of initiation of an immune response. For example, the amino acid sequence of a polypeptide encoded by a CA polynucleotide sequence may be analyzed using the default parameters of the DNASTAR computer algorithm (DNASTAR, Inc., Madison, Wis.; http://www.dnastar.com/).


Polypeptide features that may be routinely obtained using the DNASTAR computer algorithm include, but are not limited to, Garnier-Robson alpha-regions, beta-regions, turn-regions, and coil-regions (Garnier et al. J. Mol. Biol., 120: 97 (1978)); Chou-Fasman alpha-regions, beta-regions, and turn-regions (Adv. in Enzymol., 47:45-148 (1978)); Kyte-Doolittle hydrophilic regions and hydrophobic regions (J. Mol. Biol., 157:105-132 (1982)); Eisenberg alpha- and beta-amphipathic regions; Karplus-Schulz flexible regions; Emini surface-forming regions (J. Virol., 55(3):836-839 (1985)); and Jameson-Wolf regions of high antigenic index (CABIOS, 4(1):181-186 (1988)). Kyte-Doolittle hydrophilic regions and hydrophobic regions, Emini surface-forming regions, and Jameson-Wolf regions of high antigenic index (i.e., containing four or more contiguous amino acids having an antigenic index of greater than or equal to 1.5, as identified using the default parameters of the Jameson-Wolf program) can routinely be used to determine polypeptide regions that exhibit a high degree of potential for antigenicity. One approach for preparing antibodies to a protein is the selection and preparation of an amino acid sequence of all or part of the protein, chemically synthesizing the sequence and injecting it into an appropriate animal, typically a rabbit, hamster or a mouse. Oligopeptides can be selected as candidates for the production of an antibody to the CA protein based upon the oligopeptides lying in hydrophilic regions, which are thus likely to be exposed in the mature protein. Additional oligopeptides can be determined using, for example, the Antigenicity Index, Welling, G. W. et al., FEBS Lett. 188:215-218 (1985), incorporated herein by reference.


In one embodiment, the term “antibody” includes antibody fragments, as are known in the art, including Fab, Fab2, single chain antibodies (Fv for example), chimeric antibodies, etc., either produced by the modification of whole antibodies or those synthesized de novo using recombinant DNA technologies.


Methods of preparing polyclonal antibodies are known to the skilled artisan. Polyclonal antibodies can be raised in a mammal, for example, by one or more injections of an immunizing agent and, if desired, an adjuvant. Typically, the immunizing agent and/or adjuvant will be injected in the mammal by multiple subcutaneous or intraperitoneal injections. The immunizing agent may include a protein encoded by a nucleic acid of the figures or fragment thereof or a fusion protein thereof. It may be useful to conjugate the immunizing agent to a protein known to be immunogenic in the mammal being immunized. Examples of such immunogenic proteins include but are not limited to keyhole limpet hemocyanin, serum albumin, bovine thyroglobulin, and soybean trypsin inhibitor. Examples of adjuvants that may be employed include Freund's complete adjuvant and MPL-TDM adjuvant (monophosphoryl Lipid A, synthetic trehalose dicorynomycolate). The immunization protocol may be selected by one skilled in the art without undue experimentation.


The antibodies may, alternatively, be monoclonal antibodies. Monoclonal antibodies may be prepared using hybridoma methods, such as those described by Kohler and Milstein, Nature, 256:495 (1975). In a hybridoma method, a mouse, hamster, or other appropriate host animal, is typically immunized with an immunizing agent to elicit lymphocytes that produce or are capable of producing antibodies that will specifically bind to the immunizing agent. Alternatively, the lymphocytes may be immunized in vitro. The immunizing agent will typically include a polypeptide encoded by a nucleic acid of Tables 1-7, or fragment thereof or a fusion protein thereof. Generally, either peripheral blood lymphocytes (“PBLs”) are used if cells of human origin are desired, or spleen cells or lymph node cells are used if non-human mammalian sources are desired. The lymphocytes are then fused with an immortalized cell line using a suitable fusing agent, such as polyethylene glycol, to form a hybridoma cell (Goding, Monoclonal Antibodies: Principles and Practice, Academic Press, (1986) pp. 59-103). Immortalized cell lines are usually transformed mammalian cells, particularly myeloma cells of rodent, bovine and human origin. Usually, rat or mouse myeloma cell lines are employed. The hybridoma cells may be cultured in a suitable culture medium that preferably contains one or more substances that inhibit the growth or survival of the unfused, immortalized cells. For example, if the parental cells lack the enzyme hypoxanthine guanine phosphoribosyl transferase (HGPRT or HPRT), the culture medium for the hybridomas typically will include hypoxanthine, aminopterin, and thymidine (“HAT medium”), which substances prevent the growth of HGPRT-deficient cells.


Monoclonal antibody technology is used in implementing research, diagnosis and therapy. Monoclonal antibodies are used in radioimmunoassays, enzyme-linked immunosorbent assays, immunocytopathology, and flow cytometry for in vitro diagnosis, and in vivo for diagnosis and immunotherapy of human disease. Waldmann, T. A. (1991) Science 252:1657-1662. In particular, monoclonal antibodies have been widely applied to the diagnosis and therapy of cancer, wherein it is desirable to target malignant lesions while avoiding normal tissue. See, e.g., U.S. Pat. No. 4,753,894 to Frankel, et al.; U.S. Pat. No. 4,938,948 to Ring et al.; and U.S. Pat. No. 4,956,453 to Bjorn et al.


In one embodiment, the antibodies are bispecific antibodies. Bispecific antibodies are monoclonal, preferably human or humanized, antibodies that have binding specificities for at least two different antigens. A number of “humanized” antibody molecules comprising an antigen-binding site derived from a non-human immunoglobulin have been described, including chimeric antibodies having rodent V regions and their associated CDRs fused to human constant domains (Winter et al. (1991) Nature 349:293-299; Lobuglio et al. (1989) Proc. Nat. Acad. Sci. USA 86:4220-4224; Shaw et al. (1987) J Immunol. 138:4534-4538; and Brown et al. (1987) Cancer Res. 47:3577-3583), rodent CDRs grafted into a human supporting FR prior to fusion with an appropriate human antibody constant domain (Riechmann et al. (1988) Nature 332:323-327; Verhoeyen et al. (1988) Science 239:1534-1536; and Jones et al. (1986) Nature 321:522-525), and rodent CDRs supported by recombinantly veneered rodent FRs (European Patent Publication No. 519,596, published Dec. 23, 1992). These “humanized” molecules are designed to minimize unwanted immunological response toward rodent antihuman antibody molecules which limits the duration and effectiveness of therapeutic applications of those moieties in human recipients. In the present case, one of the binding specificities is for a protein encoded by a nucleic acid of Tables 1-7, or a fragment thereof, the other one is for any other antigen, and preferably for a cell-surface protein or receptor or receptor subunit, preferably one that is tumor specific.


In a preferred embodiment, the antibodies to CA are capable of reducing or eliminating the biological function of CA, as is described below. That is, the addition of anti-CA antibodies (either polyclonal or preferably monoclonal) to CA (or cells containing CA) may reduce or eliminate the CA activity. Generally, at least a 25% decrease in activity is preferred, with at least about 50% being particularly preferred and about a 95-100% decrease being especially preferred.


In a preferred embodiment the antibodies to the CA proteins are humanized antibodies. “Humanized” antibodies refer to a molecule having an antigen binding site that is substantially derived from an immunoglobulin from a non-human species and the remaining immunoglobulin structure of the molecule based upon the structure and/or sequence of a human immunoglobulin. The antigen binding site may comprise either complete variable domains fused onto constant domains or only the complementarity determining regions (CDRs) grafted onto appropriate framework regions in the variable domains. Antigen binding sites may be wild type or modified by one or more amino acid substitutions, e.g., modified to resemble human immunoglobulin more closely. Alternatively, a humanized antibody may be derived from a chimeric antibody that retains or substantially retains the antigen-binding properties of the parental, non-human, antibody but which exhibits diminished immunogenicity as compared to the parental antibody when administered to humans. The phrase “chimeric antibody,” as used herein, refers to an antibody containing sequence derived from two different antibodies (see, e.g., U.S. Pat. No. 4,816,567) that typically originate from different species. Typically, in these chimeric antibodies, the variable region of both light and heavy chains mimics the variable regions of antibodies derived from one species of mammals, while the constant portions are homologous to the sequences in antibodies derived from another. Most typically, chimeric antibodies comprise human and murine antibody fragments, generally human constant and mouse variable regions. Humanized antibodies include human immunoglobulins (recipient antibody) in which residues form a complementary determining region (CDR) of the recipient are replaced by residues from a CDR of a non-human species (donor antibody) such as mouse, rat or rabbit having the desired specificity, affinity and capacity. In some instances, Fv framework residues of the human immunoglobulin are replaced by corresponding non-human residues. Humanized antibodies may also comprise residues that are found neither in the recipient antibody nor in the imported CDR or framework sequences. In general, the humanized antibody will comprise substantially all of at least one, and typically two, variable domains, in which all or substantially all of the CDR regions correspond to those of a non-human immunoglobulin and all or substantially all of the framework residues (FR) regions are those of a human immunoglobulin consensus sequence. The humanized antibody optimally also will comprise at least a portion of an immunoglobulin constant region (Fc), typically that of a human immunoglobulin (Jones et al., Nature, 321:522-525 (1986); Riechmann et al., Nature, 332:323-329 (1988); and Presta, Curr. Op. Struct. Biol., 2:593-596 (1992)). One clear advantage to such chimeric forms is that, for example, the variable regions can conveniently be derived from presently known sources using readily available hybridomas or B cells from non human host organisms in combination with constant regions derived from, for example, human cell preparations. While the variable region has the advantage of ease of preparation, and the specificity is not affected by its source, the constant region being human, is less likely to elicit an immune response from a human subject when the antibodies are injected than would the constant region from a non-human source. However, the definition is not limited to this particular example.


Because humanized antibodies are far less immunogenic in humans than the parental mouse monoclonal antibodies, they can be used for the treatment of humans with far less risk of anaphylaxis. Thus, these antibodies may be preferred in therapeutic applications that involve in vivo administration to a human such as, e.g., use as radiation sensitizers for the treatment of neoplastic disease or use in methods to reduce the side effects of, e.g., cancer therapy. Methods for humanizing non-human antibodies are well known in the art. Generally, a humanized antibody has one or more amino acid residues introduced into it from a source that is non-human. These non-human amino acid residues are often referred to as import residues, which are typically taken from an import variable domain. Humanization can be essentially performed following the method of Winter and co-workers (Jones et al., Nature 321:522-525 (1986); Riechmann et al., Nature 332:323-327 (1988); Verhoeyen et al., Science 239:1534-1536 (1988)), by substituting rodent CDRs or CDR sequences for the corresponding sequences of a human antibody. Accordingly, such humanized antibodies are chimeric antibodies (U.S. Pat. No. 4,816,567), wherein substantially less than an intact human variable domain has been substituted by the corresponding sequence from a non-human species. In practice, humanized antibodies are typically human antibodies in which some CDR residues and possibly some FR residues are substituted by residues from analogous sites in rodent antibodies.


Human antibodies can also be produced using various techniques known in the art, including phage display libraries [Hoogenboom and Winter, J. Mol. Biol., 227:381 (1991); Marks et al., J. Mol. Biol., 222:581 (1991)]. The techniques of Cole et al. and Boerner et al. are also available for the preparation of human monoclonal antibodies [Cole et al., Monoclonal Antibodies and Cancer Therapy, Alan R. Liss, p. 77 (1985) and Boerner et al., J. Immunol., 147(1):86-95 (1991)]. Humanized antibodies may be achieved by a variety of methods including, for example: (1) grafting the non-human complementarity determining regions (CDRs) onto a human framework and constant region (a process referred to in the art as “humanizing”), or, alternatively, (2) transplanting the entire non-human variable domains, but “cloaking” them with a human-like surface by replacement of surface residues (a process referred to in the art as “veneering”). In the present invention, humanized antibodies will include both “humanized” and “veneered” antibodies. Similarly, human antibodies can be made by introducing human immunoglobulin loci into transgenic animals, e.g., mice in which the endogenous immunoglobulin genes have been partially or completely inactivated. Upon challenge, human antibody production is observed, which closely resembles that seen in humans in all respects, including gene rearrangement, assembly, and antibody repertoire. This approach is described, for example, in U.S. Pat. Nos. 5,545,807; 5,545,806; 5,569,825; 5,625,126; 5,633,425; 5,661,016, and in the following scientific publications: Marks et al., Bio/Technology 10, 779-783 (1992); Lonberg et al., Nature 368 856-859 (1994); Morrison, Nature 368, 812-13 (1994); Fishwild et al., Nature Biotechnology 14, 845-51 (1996); Neuberger, Nature Biotechnology 14, 826 (1996); Lonberg and Huszar, Intern. Rev. Immunol. 13 65-93 (1995); Jones et al., Nature 321:522-525 (1986); Morrison et al., Proc. Natl. Acad. Sci, U.S.A., 81:6851-6855 (1984); Morrison and Oi, Adv. Immunol., 44:65-92 (1988); Verhoeyer et al., Science 239:1534-1536 (1988); Padlan, Molec. Immun. 28:489-498 (1991); Padlan, Molec. Immunol. 31(3):169-217 (1994); and Kettleborough, C. A. et al., Protein Eng. 4(7):773-83 (1991) each of which is incorporated herein by reference.


The phrase “complementarity determining region” refers to amino acid sequences which together define the binding affinity and specificity of the natural Fv region of a native immunoglobulin binding site. See, e.g., Chothia et al., J. Mol. Biol. 196:901-917 (1987); Kabat et al., U.S. Dept. of Health and Human Services NIH Publication No. 91-3242 (1991). The phrase “constant region” refers to the portion of the antibody molecule that confers effector functions. In the present invention, mouse constant regions are substituted by human constant regions. The constant regions of the subject humanized antibodies are derived from human immunoglobulins. The heavy chain constant region can be selected from any of the five isotypes: alpha, delta, epsilon, gamma or mu. One method of humanizing antibodies comprises aligning the non-human heavy and light chain sequences to human heavy and light chain sequences, selecting and replacing the non-human framework with a human framework based on such alignment, molecular modeling to predict the conformation of the humanized sequence and comparing to the conformation of the parent antibody. This process is followed by repeated back mutation of residues in the CDR region that disturb the structure of the CDRs until the predicted conformation of the humanized sequence model closely approximates the conformation of the non-human CDRs of the parent non-human antibody. Such humanized antibodies may be further derivatized to facilitate uptake and clearance, e.g, via Ashwell receptors. See, e.g., U.S. Pat. Nos. 5,530,101 and 5,585,089 which are incorporated herein by reference.


Humanized antibodies to CA polypeptides can also be produced using transgenic animals that are engineered to contain human immunoglobulin loci. For example, WO 98/24893 discloses transgenic animals having a human Ig locus wherein the animals do not produce functional endogenous immunoglobulins due to the inactivation of endogenous heavy and light chain loci. WO 91/10741 also discloses transgenic non-primate mammalian hosts capable of mounting an immune response to an immunogen, wherein the antibodies have primate constant and/or variable regions, and wherein the endogenous immunoglobulin-encoding loci are substituted or inactivated. WO 96/30498 discloses the use of the Cre/Lox system to modify the immunoglobulin locus in a mammal, such as to replace all or a portion of the constant or variable region to form a modified antibody molecule. WO 94/02602 discloses non-human mammalian hosts having inactivated endogenous Ig loci and functional human Ig loci. U.S. Pat. No. 5,939,598 discloses methods of making transgenic mice in which the mice lack endogenous heavy chains, and express an exogenous immunoglobulin locus comprising one or more xenogeneic constant regions.


Using a transgenic animal described above, an immune response can be produced to a selected antigenic molecule, and antibody-producing cells can be removed from the animal and used to produce hybridomas that secrete human monoclonal antibodies. Immunization protocols, adjuvants, and the like are known in the art, and are used in immunization of, for example, a transgenic mouse as described in WO 96/33735. The monoclonal antibodies can be tested for the ability to inhibit or neutralize the biological activity or physiological effect of the corresponding protein.


In the present invention, CA polypeptides of the invention and variants thereof are used to immunize a transgenic animal as described above. Monoclonal antibodies are made using methods known in the art, and the specificity of the antibodies is tested using isolated CA polypeptides. Methods for preparation of the human or primate CA or an epitope thereof include, but are not limited to chemical synthesis, recombinant DNA techniques or isolation from biological samples. Chemical synthesis of a peptide can be performed, for example, by the classical Merrifeld method of solid phase peptide synthesis (Merrifeld, J. Am. Chem. Soc. 85:2149, 1963 which is incorporated by reference) or the FMOC strategy on a Rapid Automated Multiple Peptide Synthesis system (E. I. du Pont de Nemours Company, Wilmington, Del.) (Caprino and Han, J. Org Chem. 37:3404, 1972 which is incorporated by reference).


Polyclonal antibodies can be prepared by immunizing rabbits or other animals by injecting antigen followed by subsequent boosts at appropriate intervals. The animals are bled and sera assayed against purified CA proteins usually by ELISA or by bioassay based upon the ability to block the action of CA proteins. When using avian species, e.g., chicken, turkey and the like, the antibody can be isolated from the yolk of the egg. Monoclonal antibodies can be prepared after the method of Milstein and Kohler by fusing splenocytes from immunized mice with continuously replicating tumor cells such as myeloma or lymphoma cells. (Milstein and Kohler, Nature 256:495-497, 1975; Gulfre and Milstein, Methods in Enzymology: Immunochemical Techniques 73:1-46, Langone and Banatis eds., Academic Press, 1981 which are incorporated by reference). The hybridoma cells so formed are then cloned by limiting dilution methods and supernates assayed for antibody production by ELISA, RIA or bioassay.


The unique ability of antibodies to recognize and specifically bind to target proteins provides an approach for treating an overexpression of the protein. Thus, another aspect of the present invention provides for a method for preventing or treating diseases involving overexpression of a CA polypeptide by treatment of a patient with specific antibodies to the CA protein.


Specific antibodies, either polyclonal or monoclonal, to the CA proteins can be produced by any suitable method known in the art as discussed above. For example, murine or human monoclonal antibodies can be produced by hybridoma technology or, alternatively, the CA proteins, or an immunologically active fragment thereof, or an anti-idiotypic antibody, or fragment thereof can be administered to an animal to elicit the production of antibodies capable of recognizing and binding to the CA proteins. Such antibodies can be from any class of antibodies including, but not limited to IgG, IgA, IgM, IgD, and IgE or in the case of avian species, IgY and from any subclass of antibodies.


By immunotherapy is meant treatment of a cancer with an antibody raised against a CA protein. As used herein, immunotherapy can be passive or active. Passive immunotherapy as defined herein is the passive transfer of antibody to a recipient (patient). Active immunization is the induction of antibody and/or T-cell responses in a recipient (patient). Induction of an immune response is the result of providing the recipient with an antigen to which antibodies are raised. As appreciated by one of ordinary skill in the art, the antigen may be provided by injecting a polypeptide against which antibodies are desired to be raised into a recipient, or contacting the recipient with a nucleic acid capable of expressing the antigen and under conditions for expression of the antigen.


In a preferred embodiment, oncogenes which encode secreted growth factors may be inhibited by raising antibodies against CA proteins that are secreted proteins as described above. Without being bound by theory, antibodies used for treatment, bind and prevent the secreted protein from binding to its receptor, thereby inactivating the secreted CA protein.


In another preferred embodiment, the CA protein to which antibodies are raised is a transmembrane protein. Without being bound by theory, antibodies used for treatment, bind the extracellular domain of the CA protein and prevent it from binding to other proteins, such as circulating ligands or cell-associated molecules. The antibody may cause down-regulation of the transmembrane CA protein. As will be appreciated by one of ordinary skill in the art, the antibody may be a competitive, non-competitive or uncompetitive inhibitor of protein binding to the extracellular domain of the CA protein. The antibody is also an antagonist of the CA protein. Further, the antibody prevents activation of the transmembrane CA protein. In one aspect, when the antibody prevents the binding of other molecules to the CA protein, the antibody prevents growth of the cell. The antibody may also sensitize the cell to cytotoxic agents, including, but not limited to TNF-α, TNF-β, IL-1, INF-γ and IL-2, or chemotherapeutic agents including 5FU, vinblastine, actinomycin D, cisplatin, methotrexate, and the like. In some instances the antibody belongs to a sub-type that activates serum complement when complexed with the transmembrane protein thereby mediating cytotoxicity. Thus, cancers may be treated by administering to a patient antibodies directed against the transmembrane CA protein.


In another preferred embodiment, the antibody is conjugated to a therapeutic moiety. In one aspect the therapeutic moiety is a small molecule that modulates the activity of the CA protein. In another aspect the therapeutic moiety modulates the activity of molecules associated with or in close proximity to the CA protein. The therapeutic moiety may inhibit enzymatic activity such as protease or protein kinase activity associated with cancer.


In a preferred embodiment, the therapeutic moiety may also be a cytotoxic agent. In this method, radioisotopes, natural toxins, chemotherapy agents, or other substances (such as biological response modifiers) are chemically linked or conjugated to a monoclonal antibody to form “immunoconjugates” and “immunotoxins” which target the cytotoxic agent to tumor tissue or cells resulting in a reduction in the number of afflicted cells, thereby reducing symptoms associated with cancers, including lymphoma. Cytotoxic agents are numerous and varied and include, but are not limited to, cytotoxic drugs or toxins or active fragments of such toxins. Suitable toxins and their corresponding fragments include diphtheria A chain, exotoxin A chain, ricin A chain, abrin A chain, curcin, crotin, phenomycin, enomycin and the like. Cytotoxic agents also include radiochemicals made by conjugating radioisotopes to antibodies raised against CA proteins, or binding of a radionuclide to a chelating agent that has been covalently attached to the antibody. Targeting the therapeutic moiety to transmembrane CA proteins not only serves to increase the local concentration of therapeutic moiety in the cancer of interest, i.e., lymphoma, but also serves to reduce deleterious side effects that may be associated with the therapeutic moiety. A number of investigators have used monoclonal antibodies as carriers of cytotoxic substances in attempts to selectively direct those agents to malignant tissue. More particularly, a number of monoclonal antibodies have been conjugated to toxins such as ricin, abrin, diphtheria toxin and Pseudomonas exotoxin or to enzymatically active portions (A chains) thereof via heterobifunctional agents. See, e.g., U.S. Pat. No. 4,753,894 to Frankel et al.; Nevelle, et al. (1982) Immunol Rev 62:75-91; Ross et al. (1980) Eur. J. Biochem 104; Vitteta et al. (1982) Immunol Rev 62:158-183; Raso et al. (1982) Cancer Res 42:457-464, and Trowbridge et al. (1981) Nature 294:171-173.


In another preferred embodiment, the CA protein against which the antibodies are raised is an intracellular protein. In this case, the antibody may be conjugated to a protein that facilitates entry into the cell. In one case, the antibody enters the cell by endocytosis. In another embodiment, a nucleic acid encoding the antibody is administered to the individual or cell. Moreover, wherein the CA protein can be targeted within a cell, e.g., the nucleus, an antibody thereto contains a signal for that target localization, e.g., a nuclear localization signal.


The CA antibodies of the invention specifically bind to CA proteins. By “specifically bind” herein is meant that the antibodies bind to the protein with a binding constant in the range of 10−4-10−6 M−1, with a preferred range being 10−7-10−9 M−1.


In a preferred embodiment, the CA protein is purified or isolated after expression. CA proteins may be isolated or purified in a variety of ways known to those skilled in the art depending on what other components are present in the sample. Standard purification methods include electrophoretic, molecular, immunological and chromatographic techniques, including ion exchange, hydrophobic, affinity, and reverse-phase HPLC chromatography, and chromatofocusing. For example, the CA protein may be purified using a standard anti-CA antibody column. Ultrafiltration and diafiltration techniques, in conjunction with protein concentration, are also useful. For general guidance in suitable purification techniques, see Scopes, R., Protein Purification, Springer-Verlag, NY (1982). The degree of purification necessary will vary depending on the use of the CA protein. In some instances no purification will be necessary.


Detection of Cancer Phenotype


Once expressed and purified if necessary, the CA proteins and nucleic acids are useful in a number of applications. In one aspect, the expression levels of genes are determined for different cellular states in the cancer phenotype; that is, the expression levels of genes in normal tissue and in cancer tissue (and in some cases, for varying severities of lymphoma that relate to prognosis, as outlined below) are evaluated to provide expression profiles. An expression profile of a particular cell state or point of development is essentially a “fingerprint” of the state; while two states may have any particular gene similarly expressed, the evaluation of a number of genes simultaneously allows the generation of a gene expression profile that is unique to the state of the cell. By comparing expression profiles of cells in different states, information regarding which genes are important (including both up- and down-regulation of genes) in each of these states is obtained. Then, diagnosis may be done or confirmed: does tissue from a particular patient have the gene expression profile of normal or cancer tissue.


“Differential expression,” or equivalents used herein, refers to both qualitative as well as quantitative differences in the temporal and/or cellular expression patterns of genes, within and among the cells. Thus, a differentially expressed gene can qualitatively have its expression altered, including an activation or inactivation, in, for example, normal versus cancer tissue. That is, genes may be turned on or turned off in a particular state, relative to another state. As is apparent to the skilled artisan, any comparison of two or more states can be made. Such a qualitatively regulated gene will exhibit an expression pattern within a state or cell type which is detectable by standard techniques in one such state or cell type, but is not detectable in both. Alternatively, the determination is quantitative in that expression is increased or decreased; that is, the expression of the gene is either up-regulated, resulting in an increased amount of transcript, or down-regulated, resulting in a decreased amount of transcript. The degree to which expression differs need only be large enough to quantify via standard characterization techniques as outlined below, such as by use of Affymetrix GeneChip® expression arrays, Lockhart, Nature Biotechnology, 14:1675-1680 (1996), hereby expressly incorporated by reference. Other techniques include, but are not limited to, quantitative reverse transcriptase PCR, Northern analysis and RNase protection. As outlined above, preferably the change in expression (i.e. upregulation or downregulation) is at least about 50%, more preferably at least about 100%, more preferably at least about 150%, more preferably, at least about 200%, with from 300 to at least 1000% being especially preferred.


As will be appreciated by those in the art, this may be done by evaluation at either the gene transcript, or the protein level; that is, the amount of gene expression may be monitored using nucleic acid probes to the DNA or RNA equivalent of the gene transcript, and the quantification of gene expression levels, or, alternatively, the final gene product itself (protein) can be monitored, for example through the use of antibodies to the CA protein and standard immunoassays (ELISAs, etc.) or other techniques, including mass spectroscopy assays, 2D gel electrophoresis assays, etc. Thus, the proteins corresponding to CA genes, i.e. those identified as being important in a particular cancer phenotype, i.e., lymphoma, can be evaluated in a diagnostic test specific for that cancer.


In a preferred embodiment, gene expression monitoring is done and a number of genes, i.e. an expression profile, is monitored simultaneously, although multiple protein expression monitoring can be done as well. Similarly, these assays may be done on an individual basis as well.


In this embodiment, the CA nucleic acid probes may be attached to biochips as outlined herein for the detection and quantification of CA sequences in a particular cell. The assays are done as is known in the art. As will be appreciated by those in the art, any number of different CA sequences may be used as probes, with single sequence assays being used in some cases, and a plurality of the sequences described herein being used in other embodiments. In addition, while solid-phase assays are described, any number of solution based assays may be done as well.


In a preferred embodiment, both solid and solution based assays may be used to detect CA sequences that are up-regulated or down-regulated in cancers as compared to normal tissue. In instances where the CA sequence has been altered but shows the same expression profile or an altered expression profile, the protein will be detected as outlined herein.


In a preferred embodiment nucleic acids encoding the CA protein are detected. Although DNA or RNA encoding the CA protein may be detected, of particular interest are methods wherein the mRNA encoding a CA protein is detected. The presence of mRNA in a sample is an indication that the CA gene has been transcribed to form the mRNA, and suggests that the protein is expressed. Probes to detect the mRNA can be any nucleotide/deoxynucleotide probe that is complementary to and base pairs with the mRNA-and includes but is not limited to oligonucleotides, cDNA or RNA. Probes also should contain a detectable label, as defined herein. In one method the mRNA is detected after immobilizing the nucleic acid to be examined on a solid support such as nylon membranes and hybridizing the probe with the sample. Following washing to remove the non-specifically bound probe, the label is detected. In another method detection of the mRNA is performed in situ. In this method pemeabilized cells or tissue samples are contacted with a detectably labeled nucleic acid probe for sufficient time to allow the probe to hybridize with the target mRNA. Following washing to remove the non-specifically bound probe, the label is detected. For example a digoxygenin labeled riboprobe (RNA probe) that is complementary to the mRNA encoding a CA protein is detected by binding the digoxygenin with an anti-digoxygenin secondary antibody and developed with nitro blue tetrazolium and 5-bromo-4-chloro-3-indoyl phosphate.


In a preferred embodiment, any of the three classes of proteins as described herein (secreted, transmembrane or intracellular proteins) are used in diagnostic assays. The CA proteins, antibodies, nucleic acids, modified proteins and cells containing CA sequences are used in diagnostic assays. This can be done on an individual gene or corresponding polypeptide level, or as sets of assays.


As described and defined herein, CA proteins find use as markers of cancers, including lymphomas such as, but not limited to, Hodgkin's and non-Hodgkin's lymphoma. Detection of these proteins in putative cancer tissue or patients allows for a determination or diagnosis of the type of cancer. Numerous methods known to those of ordinary skill in the art find use in detecting cancers. In one embodiment, antibodies are used to detect CA proteins. A preferred method separates proteins from a sample or patient by electrophoresis on a gel (typically a denaturing and reducing protein gel, but may be any other type of gel including isoelectric focusing gels and the like). Following separation of proteins, the CA protein is detected by immunoblotting with antibodies raised against the CA protein. Methods of immunoblotting are well known to those of ordinary skill in the art.


In another preferred method, antibodies to the CA protein find use in in situ imaging techniques. In this method cells are contacted with from one to many antibodies to the CA protein(s). Following washing to remove non-specific antibody binding, the presence of the antibody or antibodies is detected. In one embodiment the antibody is detected by incubating with a secondary antibody that contains a detectable label. In another method the primary antibody to the CA protein(s) contains a detectable label. In another preferred embodiment each one of multiple primary antibodies contains a distinct and detectable label. This method finds particular use in simultaneous screening for a plurality of CA proteins. As will be appreciated by one of ordinary skill in the art, numerous other histological imaging techniques are useful in the invention.


In a preferred embodiment the label is detected in a fluorometer that has the ability to detect and distinguish emissions of different wavelengths. In addition, a fluorescence activated cell sorter (FACS) can be used in the method.


In another preferred embodiment, antibodies find use in diagnosing cancers from blood samples. As previously described, certain CA proteins are secreted/circulating molecules. Blood samples, therefore, are useful as samples to be probed or tested for the presence of secreted CA proteins. Antibodies can be used to detect the CA proteins by any of the previously described immunoassay techniques including ELISA, immunoblotting (Western blotting), immunoprecipitation, BIACORE technology and the like, as will be appreciated by one of ordinary skill in the art.


In a preferred embodiment, in situ hybridization of labeled CA nucleic acid probes to tissue arrays is done. For example, arrays of tissue samples, including CA tissue and/or normal tissue, are made. In situ hybridization as is known in the art can then be done.


It is understood that when comparing the expression fingerprints between an individual and a standard, the skilled artisan can make a diagnosis as well as a prognosis. It is further understood that the genes that indicate diagnosis may differ from those that indicate prognosis.


In a preferred embodiment, the CA proteins, antibodies, nucleic acids, modified proteins and cells containing CA sequences are used in prognosis assays. As above, gene expression profiles can be generated that correlate to cancer, especially lymphoma, severity, in terms of long term prognosis. Again, this may be done on either a protein or gene level, with the use of genes being preferred. As above, the CA probes are attached to biochips for the detection and quantification of CA sequences in a tissue or patient. The assays proceed as outlined for diagnosis.


Screening for CA-Targeted Drugs


In one embodiment, any of the CA sequences as described herein are used in drug screening assays. The CA proteins, antibodies, nucleic acids, modified proteins and cells containing CA sequences are used in drug screening assays or by evaluating the effect of drug candidates on a “gene expression profile” or expression profile of polypeptides. In one embodiment, the expression profiles are used, preferably in conjunction with high throughput screening techniques to allow monitoring for expression profile genes after treatment with a candidate agent, Zlokarnik, et al., Science 279, 84-8 (1998), Heid, et al., Genome Res., 6:986-994 (1996).


In another embodiment, the CA proteins, antibodies, nucleic acids, modified proteins and cells containing the native or modified CA proteins are used in screening assays. That is, the present invention provides novel methods for screening for compositions that modulate the cancer phenotype. As above, this can be done by screening for modulators of gene expression or for modulators of protein activity. Similarly, this may be done on an individual gene or protein level or by evaluating the effect of drug candidates on a “gene expression profile”. In a preferred embodiment, the expression profiles are used, preferably in conjunction with high throughput screening techniques to allow monitoring for expression profile genes after treatment with a candidate agent, see Zlokarnik, supra.


Having identified the CA genes herein, a variety of assays to evaluate the effects of agents on gene expression may be executed. In a preferred embodiment, assays may be run on an individual gene or protein level. That is, having identified a particular gene as aberrantly regulated in cancer, candidate bioactive agents may be screened to modulate the gene's regulation. “Modulation” thus includes both an increase and a decrease in gene expression or activity. The preferred amount of modulation will depend on the original change of the gene expression in normal versus tumor tissue, with changes of at least 10%, preferably 50%, more preferably 100-300%, and in some embodiments 300-1000% or greater. Thus, if a gene exhibits a 4 fold increase in tumor compared to normal tissue, a decrease of about four fold is desired; a 10 fold decrease in tumor compared to normal tissue gives a 10 fold increase in expression for a candidate agent is desired, etc. Alternatively, where the CA sequence has been altered but shows the same expression profile or an altered expression profile, the protein will be detected as outlined herein.


As will be appreciated by those in the art, this may be done by evaluation at either the gene or the protein level; that is, the amount of gene expression may be monitored using nucleic acid probes and the quantification of gene expression levels, or, alternatively, the level of the gene product itself can be monitored, for example through the use of antibodies to the CA protein and standard inmuunoassays. Alternatively, binding and bioactivity assays with the protein may be done as outlined below.


In a preferred embodiment, gene expression monitoring is done and a number of genes, i.e. an expression profile, is monitored simultaneously, although multiple protein expression monitoring can be done as well.


In this embodiment, the CA nucleic acid probes are attached to biochips as outlined herein for the detection and quantification of CA sequences in a particular cell. The assays are further described below.


Generally, in a preferred embodiment, a candidate bioactive agent is added to the cells prior to analysis. Moreover, screens are provided to identify a candidate bioactive agent that modulates a particular type of cancer, modulates CA proteins, binds to a CA protein, or interferes between the binding of a CA protein and an antibody.


The term “candidate bioactive agent” or “drug candidate” or grammatical equivalents as used herein describes any molecule, e.g., protein, oligopeptide, small organic or inorganic molecule, polysaccharide, polynucleotide, etc., to be tested for bioactive agents that are capable of directly or indirectly altering either the cancer phenotype, binding to and/or modulating the bioactivity of a CA protein, or the expression of a CA sequence, including both nucleic acid sequences and protein sequences. In a particularly preferred embodiment, the candidate agent suppresses a CA phenotype, for example to a normal tissue fingerprint. Similarly, the candidate agent preferably suppresses a severe CA phenotype. Generally a plurality of assay mixtures are run in parallel with different agent concentrations to obtain a differential response to the various concentrations. Typically, one of these concentrations serves as a negative control, i.e., at zero concentration or below the level of detection.


In one aspect, a candidate agent will neutralize the effect of a CA protein. By “neutralize” is meant that activity of a protein is either inhibited or counter acted against so as to have substantially no effect on a cell.


Candidate agents encompass numerous chemical classes, though typically they are organic or inorganic molecules, preferably small organic compounds having a molecular weight of more than 100 and less than about 2,500 Daltons. Preferred small molecules are less than 2000, or less than 1500 or less than 1000 or less than 500 D. Candidate agents comprise functional groups necessary for structural interaction with proteins, particularly hydrogen bonding, and typically include at least an amine, carbonyl, hydroxyl or carboxyl group, preferably at least two of the functional chemical groups. The candidate agents often comprise cyclical carbon or heterocyclic structures and/or aromatic or polyaromatic structures substituted with one or more of the above functional groups. Candidate agents are also found among biomolecules including peptides, saccharides, fatty acids, steroids, purines, pyrimidines, derivatives, structural analogs or combinations thereof. Particularly preferred are peptides.


Candidate agents are obtained from a wide variety of sources including libraries of synthetic or natural compounds. For example, numerous means are available for random and directed synthesis of a wide variety of organic compounds and biomolecules, including expression of randomized oligonucleotides. Alternatively, libraries of natural compounds in the form of bacterial, fungal, plant and animal extracts are available or readily produced. Additionally, natural or synthetically produced libraries and compounds are readily modified through conventional chemical, physical and biochemical means. Known pharmacological agents may be subjected to directed or random chemical modifications, such as acylation, alkylation, esterification, or amidification to produce structural analogs.


In one embodiment, the candidate bioactive agents are proteins. By “protein” herein is meant at least two covalently attached amino acids, which includes proteins, polypeptides, oligopeptides and peptides. The protein may be made up of naturally occurring amino acids and peptide bonds, or synthetic peptidomimetic structures. Thus “amino acid”, or “peptide residue”, as used herein means both naturally occurring and synthetic amino acids. For example, homo-phenylalanine, citrulline and norleucine are considered amino acids for the purposes of the invention. “Amino acid” also includes imino acid residues such as proline and hydroxyproline. The side chains may be in either the (R) or the (S) configuration. In the preferred embodiment, the amino acids are in the (S) or L-configuration. If non-naturally occurring side chains are used, non-amino acid substituents may be used, for example to prevent or retard in vivo degradations.


In a preferred embodiment, the candidate bioactive agents are naturally occurring proteins or fragments of naturally occurring proteins. Thus, for example, cellular extracts containing proteins, or random or directed digests of proteinaceous cellular extracts, may be used. In this way libraries of prokaryotic and eukaryotic proteins may be made for screening in the methods of the invention. Particularly preferred in this embodiment are libraries of bacterial, fungal, viral, and mammalian proteins, with the latter being preferred, and human proteins being especially preferred.


In another preferred embodiment, the candidate bioactive agents are peptides of from about 5 to about 30 amino acids, with from about 5 to about 20 amino acids being preferred, and from about 7 to about 15 being particularly preferred. The peptides may be digests of naturally occurring proteins as is outlined above, random peptides, or “biased” random peptides. By “randomized” or grammatical equivalents herein is meant that each nucleic acid and peptide consists of essentially random nucleotides and amino acids, respectively. Since generally these random peptides (or nucleic acids, discussed below) are chemically synthesized, they may incorporate any nucleotide or amino acid at any position. The synthetic process can be designed to generate randomized proteins or nucleic acids, to allow the formation of all or most of the possible combinations over the length of the sequence, thus forming a library of randomized candidate bioactive proteinaceous agents.


In one embodiment, the library is fully randomized, with no sequence preferences or constants at any position. In a preferred embodiment, the library is biased. That is, some positions within the sequence are either held constant, or are selected from a limited number of possibilities. For example, in a preferred embodiment, the nucleotides or amino acid residues are randomized within a defined class, for example, of hydrophobic amino acids, hydrophilic residues, sterically biased (either small or large) residues, towards the creation of nucleic acid binding domains, the creation of cysteines, for cross-linking, prolines for SH-3 domains, serines, threonines, tyrosines or histidines for phosphorylation sites, etc., or to purines, etc.


In one embodiment, the candidate bioactive agents are nucleic acids. As described generally for proteins, nucleic acid candidate bioactive agents may be naturally occurring nucleic acids, random nucleic acids, or “biased” random nucleic acids. In another embodiment, the candidate bioactive agents are organic chemical moieties, a wide variety of which are available in the literature.


In assays for testing alteration of the expression profile of one or more CA genes, after the candidate agent has been added and the cells allowed to incubate for some period of time, a nucleic acid sample containing the target sequences to be analyzed is prepared. The target sequence is prepared using known techniques (e.g., converted from RNA to labeled cDNA, as described above) and added to a suitable microarray. For example, an in vitro reverse transcription with labels covalently attached to the nucleosides is performed. Generally, the nucleic acids are labeled with a label as defined herein, especially with biotin-FITC or PE, Cy3 and Cy5.


As will be appreciated by those in the art, these assays can be direct hybridization assays or can comprise “sandwich assays”, which include the use of multiple probes, as is generally outlined in U.S. Pat. Nos. 5,681,702, 5,597,909, 5,545,730, 5,594,117, 5,591,584, 5,571,670, 5,580,731, 5,571,670, 5,591,584, 5,624,802, 5,635,352, 5,594,118, 5,359,100, 5,124,246 and 5,681,697, all of which are hereby incorporated by reference. In this embodiment, in general, the target nucleic acid is prepared as outlined above, and then added to the biochip comprising a plurality of nucleic acid probes, under conditions that allow the formation of a hybridization complex.


A variety of hybridization conditions may be used in the present invention, including high, moderate and low stringency conditions as outlined above. The assays are generally run under stringency conditions that allow formation of the label probe hybridization complex only in the presence of target. Stringency can be controlled by altering a step parameter that is a thermodynamic variable, including, but not limited to, temperature, formamide concentration, salt concentration, chaotropic salt concentration, pH, organic solvent concentration, etc. These parameters may also be used to control non-specific binding, as is generally outlined in U.S. Pat. No. 5,681,697. Thus it may be desirable to perform certain steps at higher stringency conditions to reduce non-specific binding.


The reactions outlined herein may be accomplished in a variety of ways, as will be appreciated by those in the art. Components of the reaction may be added simultaneously, or sequentially, in any order, with preferred embodiments outlined below. In addition, the reaction may include a variety of other reagents in the assays. These include reagents like salts, buffers, neutral proteins, e.g. albumin, detergents, etc which may be used to facilitate optimal hybridization and detection, and/or reduce non-specific or background interactions. Also reagents that otherwise improve the efficiency of the assay, such as protease inhibitors, nuclease inhibitors, anti-microbial agents, etc., may be used, depending on the sample preparation methods and purity of the target. In addition, either solid phase or solution based (i.e., kinetic PCR) assays may be used.


Once the assay is run, the data are analyzed to determine the expression levels, and changes in expression levels as between states, of individual genes, forming a gene expression profile.


In a preferred embodiment, as for the diagnosis and prognosis applications, having identified the differentially expressed gene(s) or mutated gene(s) important in any one state, screens can be run to test for alteration of the expression of the CA genes individually. That is, screening for modulation of regulation of expression of a single gene can be done. Thus, for example, in the case of target genes whose presence or absence is unique between two states, screening is done for modulators of the target gene expression.


In addition, screens can be done for novel genes that are induced in response to a candidate agent. After identifying a candidate agent based upon its ability to suppress a CA expression pattern leading to a normal expression pattern, or modulate a single CA gene expression profile so as to mimic the expression of the gene from normal tissue, a screen as described above can be performed to identify genes that are specifically modulated in response to the agent. Comparing expression profiles between normal tissue and agent treated CA tissue reveals genes that are not expressed in normal tissue or CA tissue, but are expressed in agent treated tissue. These agent specific sequences can be identified and used by any of the methods described herein for CA genes or proteins. In particular these sequences and the proteins they encode find use in marking or identifying agent-treated cells. In addition, antibodies can be raised against the agent-induced proteins and used to target novel therapeutics to the treated CA tissue sample.


Thus, in one embodiment, a candidate agent is administered to a population of CA cells, that thus has an associated CA expression profile. By “administration” or “contacting” herein is meant that the candidate agent is added to the cells in such a manner as to allow the agent to act upon the cell, whether by uptake and intracellular action, or by action at the cell surface. In some embodiments, nucleic acid encoding a proteinaceous candidate agent (i.e. a peptide) may be put into a viral construct such as a retroviral construct and added to the cell, such that expression of the peptide agent is accomplished; see PCT US97/01019, hereby expressly incorporated by reference.


Once the candidate agent has been administered to the cells, the cells can be washed if desired and are allowed to incubate under preferably physiological conditions for some period of time. The cells are then harvested and a new gene expression profile is generated, as outlined herein.


Thus, for example, CA tissue may be screened for agents that reduce or suppress the CA phenotype. A change in at least one gene of the expression profile indicates that the agent has an effect on CA activity. By defining such a signature for the CA phenotype, screens for new drugs that alter the phenotype can be devised. With this approach, the drug target need not be known and need not be represented in the original expression screening platform, nor does the level of transcript for the target protein need to change.


In a preferred embodiment, as outlined above, screens may be done on individual genes and gene products (proteins). That is, having identified a particular differentially expressed gene as important in a particular state, screening of modulators of either the expression of the gene or the gene product itself can be done. The gene products of differentially expressed genes are sometimes referred to herein as “CA proteins” or “CAP”. The CAP may be a fragment, or alternatively, be the full-length protein to the fragment encoded by the nucleic acids of Tables 1-7 (human genomic sequences of SEQ ID NOS: 6, 16, 26, 40, 52, 60 and 66, and sequences of SEQ ID NOS: 7, 9, 17, 19, 21, 27, 29, 41, 43, 45, 47, 53, 61, 67, 69, 71 and 73 corresponding to the human mRNAs generated therefrom). In a preferred embodiment, the CAP is selected from the human protein sequences shown in Tables 1-7 (of SEQ ID NOS: 8, 10, 18, 20, 22, 28, 30, 42, 44, 46, 48, 54, 62, 68, 70, 72 and 74). In another embodiment, the sequences are sequence variants as further described herein.


Preferably, the CAP is a fragment approximately 14 to 24 amino acids in length. More preferably the fragment is a soluble fragment. Preferably, the fragment includes a non-transmembrane region. In a preferred embodiment, the fragment has an N-terminal Cys to aid in solubility. In one embodiment, the C-terminus of the fragment is kept as a free acid and the N-terminus is a free amine to aid in coupling, e.g., to a cysteine.


In one embodiment the CA proteins are conjugated to an immunogenic agent as discussed herein. In one embodiment the CA protein is conjugated to BSA.


In a preferred embodiment, screening is done to alter the biological function of the expression product of the CA gene. Again, having identified the importance of a gene in a particular state, screening for agents that bind and/or modulate the biological activity of the gene product can be run as is more fully outlined below.


In a preferred embodiment, screens are designed to first find candidate agents that can bind to CA proteins, and then these agents may be used in assays that evaluate the ability of the candidate agent to modulate the CAP activity and the cancer phenotype. Thus, as will be appreciated by those in the art, there are a number of different assays that may be run; binding assays and activity assays.


In a preferred embodiment, binding assays are done. In general, purified or isolated gene product is used; that is, the gene products of one or more CA nucleic acids are made. In general, this is done as is known in the art. For example, antibodies are generated to the protein gene products, and standard immunoassays are run to determine the amount of protein present. Alternatively, cells comprising the CA proteins can be used in the assays.


Thus, in a preferred embodiment, the methods comprise combining a CA protein and a candidate bioactive agent, and determining the binding of the candidate agent to the CA protein. Preferred embodiments utilize the human or mouse CA protein, although other mammalian proteins may also be used, for example for the development of animal models of human disease. In some embodiments, as outlined herein, variant or derivative CA proteins may be used.


Generally, in a preferred embodiment of the methods herein, the CA protein or the candidate agent is non-diffusably bound to an insoluble support having isolated sample receiving areas (e.g. a microtiter plate, an array, etc.). The insoluble support may be made of any composition to which the compositions can be bound, is readily separated from soluble material, and is otherwise compatible with the overall method of screening. The surface of such supports may be solid or porous and of any convenient shape. Examples of suitable insoluble supports include microtiter plates, arrays, membranes and beads. These are typically made of glass, plastic (e.g., polystyrene), polysaccharides, nylon or nitrocellulose, Teflon®g, etc. Microtiter plates and arrays are especially convenient because a large number of assays can be carried out simultaneously, using small amounts of reagents and samples.


The particular manner of binding of the composition is not crucial so long as it is compatible with the reagents and overall methods of the invention, maintains the activity of the composition and is nondiffusable. Preferred methods of binding include the use of antibodies (which do not sterically block either the ligand binding site or activation sequence when the protein is bound to the support), direct binding to “sticky” or ionic supports, chemical crosslinking, the synthesis of the protein or agent on the surface, etc. Following binding of the protein or agent, excess unbound material is removed by washing. The sample receiving areas may then be blocked through incubation with bovine serum albumin (BSA), casein or other innocuous protein or other moiety.


In a preferred embodiment, the CA protein is bound to the support, and a candidate bioactive agent is added to the assay. Alternatively, the candidate agent is bound to the support and the CA protein is added. Novel binding agents include specific antibodies, non-natural binding agents identified in screens of chemical libraries, peptide analogs, etc. Of particular interest are screening assays for agents that have a low toxicity for human cells. A wide variety of assays may be used for this purpose, including labeled in vitro protein-protein binding assays, electrophoretic mobility shift assays, immunoassays for protein binding, functional assays (phosphorylation assays, etc.) and the like.


The determination of the binding of the candidate bioactive agent to the CA protein may be done in a number of ways. In a preferred embodiment, the candidate bioactive agent is labeled, and binding determined directly. For example, this may be done by attaching all or a portion of the CA protein to a solid support, adding a labeled candidate agent (for example a fluorescent label), washing off excess reagent, and determining whether the label is present on the solid support. Various blocking and washing steps may be utilized as is known in the art.


By “labeled” herein is meant that the compound is either directly or indirectly labeled with a label which provides a detectable signal, e.g. radioisotope, fluorescers, enzyme, antibodies, particles such as magnetic particles, chemiluminescers, or specific binding molecules, etc. Specific binding molecules include pairs, such as biotin and streptavidin, digoxin and antidigoxin etc. For the specific binding members, the complementary member would normally be labeled with a molecule which provides for detection, in accordance with known procedures, as outlined above. The label can directly or indirectly provide a detectable signal.


In some embodiments, only one of the components is labeled. For example, the proteins (or proteinaceous candidate agents) may be labeled at tyrosine positions using 125I, or with fluorophores. Alternatively, more than one component may be labeled with different labels; using 125, for the proteins, for example, and a fluorophore for the candidate agents.


In a preferred embodiment, the binding of the candidate bioactive agent is determined through the use of competitive binding assays. In this embodiment, the competitor is a binding moiety known to bind to the target molecule (i.e. CA protein), such as an antibody, peptide, binding partner, ligand, etc. Under certain circumstances, there may be competitive binding as between the bioactive agent and the binding moiety, with the binding moiety displacing the bioactive agent.


In one embodiment, the candidate bioactive agent is labeled. Either the candidate bioactive agent, or the competitor, or both, is added first to the protein for a time sufficient to allow binding, if present. Incubations may be performed at any temperature which facilitates optimal activity, typically between 4 and 40° C. Incubation periods are selected for optimum activity, but may also be optimized to facilitate rapid high throughput screening. Typically between 0.1 and 1 hour will be sufficient. Excess reagent is generally removed or washed away. The second component is then added, and the presence or absence of the labeled component is followed, to indicate binding.


In a preferred embodiment, the competitor is added first, followed by the candidate bioactive agent. Displacement of the competitor is an indication that the candidate bioactive agent is binding to the CA protein and thus is capable of binding to, and potentially modulating, the activity of the CA protein. In this embodiment, either component can be labeled. Thus, for example, if the competitor is labeled, the presence of label in the wash solution indicates displacement by the agent. Alternatively, if the candidate bioactive agent is labeled, the presence of the label on the support indicates displacement.


In an alternative embodiment, the candidate bioactive agent is added first, with incubation and washing, followed by the competitor. The absence of binding by the competitor may indicate that the bioactive agent is bound to the CA protein with a higher affinity. Thus, if the candidate bioactive agent is labeled, the presence of the label on the support, coupled with a lack of competitor binding, may indicate that the candidate agent is capable of binding to the CA protein.


In a preferred embodiment, the methods comprise differential screening to identity bioactive agents that are capable of modulating the activity of the CA proteins. In this embodiment, the methods comprise combining a CA protein and a competitor in a first sample. A second sample comprises a candidate bioactive agent, a CA protein and a competitor. The binding of the competitor is determined for both samples, and a change, or difference in binding between the two samples indicates the presence of an agent capable of binding to the CA protein and potentially modulating its activity. That is, if the binding of the competitor is different in the second sample relative to the first sample, the agent is capable of binding to the CA protein.


Alternatively, a preferred embodiment utilizes differential screening to identify drug candidates that bind to the native CA protein, but cannot bind to modified CA proteins. The structure of the CA protein may be modeled, and used in rational drug design to synthesize agents that interact with that site. Drug candidates that affect CA bioactivity are also identified by screening drugs for the ability to either enhance or reduce the activity of the protein.


Positive controls and negative controls may be used in the assays. Preferably all control and test samples are performed in at least triplicate to obtain statistically significant results. Incubation of all samples is for a time sufficient for the binding of the agent to the protein. Following incubation, all samples are washed free of non-specifically bound material and the amount of bound, generally labeled agent determined. For example, where a radiolabel is employed, the samples may be counted in a scintillation counter to determine the amount of bound compound.


A variety of other reagents may be included in the screening assays. These include reagents like salts, neutral proteins, e.g. albumin, detergents, etc which may be used to facilitate optimal protein-protein binding and/or reduce non-specific or background interactions. Also reagents that otherwise improve the efficiency of the assay, such as protease inhibitors, nuclease inhibitors, anti-microbial agents, etc., may be used. The mixture of components may be added in any order that provides for the requisite binding.


Screening for agents that modulate the activity of CA proteins may also be done. In a preferred embodiment, methods for screening for a bioactive agent capable of modulating the activity of CA proteins comprise the steps of adding a candidate bioactive agent to a sample of CA proteins, as above, and determining an alteration in the biological activity of CA proteins. “Modulating the activity of a CA protein” includes an increase in activity, a decrease in activity, or a change in the type or kind of activity present. Thus, in this embodiment, the candidate agent should both bind to CA proteins (although this may not be necessary), and alter its biological or biochemical activity as defined herein. The methods include both in vitro screening methods, as are generally outlined above, and in vivo screening of cells for alterations in the presence, distribution, activity or amount of CA proteins.


Thus, in this embodiment, the methods comprise combining a CA sample and a candidate bioactive agent, and evaluating the effect on CA activity. By “CA activity” or grammatical equivalents herein is meant one of the CA protein's biological activities, including, but not limited to, its role in tumorigenesis, including cell division, preferably in lymphatic tissue, cell proliferation, tumor growth and transformation of cells. In one embodiment, CA activity includes activation of or by a protein encoded by a nucleic acid of Tables 1-7. An inhibitor of CA activity is the inhibition of any one or more CA activities.


In a preferred embodiment, the activity of the CA protein is increased; in another preferred embodiment, the activity of the CA protein is decreased. Thus, bioactive agents that are antagonists are preferred in some embodiments, and bioactive agents that are agonists may be preferred in other embodiments.


In a preferred embodiment, the invention provides methods for screening for bioactive agents capable of modulating the activity of a CA protein. The methods comprise adding a candidate bioactive agent, as defined above, to a cell comprising CA proteins. Preferred cell types include almost any cell. The cells contain a recombinant nucleic acid that encodes a CA protein. In a preferred embodiment, a library of candidate agents is tested on a plurality of cells.


In one aspect, the assays are evaluated in the presence or absence or previous or subsequent exposure of physiological signals, for example hormones, antibodies, peptides, antigens, cytokines, growth factors, action potentials, pharmacological agents including chemotherapeutics, radiation, carcinogenics, or other cells (i.e. cell-cell contacts). In another example, the determinations are determined at different stages of the cell cycle process.


In this way, bioactive agents are identified. Compounds with pharmacological activity are able to enhance or interfere with the activity of the CA protein.


Applications of the Invention


In one embodiment, a method of inhibiting cancer cell division is provided. In another embodiment, a method of inhibiting tumor growth is provided. In a further embodiment, methods of treating cells or individuals with cancer are provided.


The method comprises administration of a cancer inhibitor. In particular embodiments, the cancer inhibitor is an antisense molecule, a pharmaceutical composition, a therapeutic agent or small molecule, or a monoclonal, polyclonal, chimeric or humanized antibody. In particular embodiments, a therapeutic agent is coupled with a an antibody, preferable a monoclonal antobody.


In other embodiments, methods for detection or diagnosis of cancer cells in an individual are provided. In particular embodiments, the diagnostic/detection agent is a small molecule that pereferentially binds to a CAP according to the invention. In one embodiment, the diagnostic/detection agent is an antibody, preferably a monoclonal antobody, preferably linked to a detectable agent.


In other embodiments of the invention, animal models and transgenic animals are provided, which find use in generating animal models of cancers, particularly lymphomas and carcinomas.


(a) Antisense Molecules


In one embodiment, the cancer inhibitor is an antisense molecule. Antisense molecules as used herein include antisense or sense oligonucleotides comprising a single-stranded nucleic acid sequence (either RNA or DNA) capable of binding to target mRNA (sense) or DNA (antisense) sequences for cancer molecules. Antisense or sense oligonucleotides, according to the present invention, comprise a fragment generally at least about 14 nucleotides, preferably from about 14 to 30 nucleotides. The ability to derive an antisense or a sense oligonucleotide, based upon a cDNA sequence encoding a given protein is described in, for example, Stein and Cohen, Cancer Res. 48:2659, (1988) and van der Krol et al., BioTechniques 6:958, (1988).


Antisense molecules can be modified or unmodified RNA, DNA, or mixed polymer oligonucleotides. These molecules function by specifically binding to matching sequences resulting in inhibition of peptide synthesis (Wu-Pong, November 1994, BioPharm, 20-33) either by steric blocking or by activating an RNase H enzyme. Antisense molecules can also alter protein synthesis by interfering with RNA processing or transport from the nucleus into the cytoplasm (Mukhopadhyay & Roth, 1996, Crit. Rev. in Oncogenesis 7, 151-190). In addition, binding of single stranded DNA to RNA can result in nuclease-mediated degradation of the heteroduplex (Wu-Pong, supra). Backbone modified DNA chemistry which have thus far been shown to act as substrates for RNase H are phosphorothioates, phosphorodithioates, borontrifluoridates, and 2′-arabino and 2′-fluoro arabino-containing oligonucleotides.


Antisense molecules may be introduced into a cell containing the target nucleotide sequence by formation of a conjugate with a ligand binding molecule, as described in WO 91/04753. Suitable ligand binding molecules include, but are not limited to, cell surface receptors, growth factors, other cytokines, or other ligands that bind to cell surface receptors. Preferably, conjugation of the ligand binding molecule does not substantially interfere with the ability of the ligand binding molecule to bind to its corresponding molecule or receptor, or block entry of the sense or antisense oligonucleotide or its conjugated version into the cell. Alternatively, a sense or an antisense oligonucleotide may be introduced into a cell containing the target nucleic acid sequence by formation of an oligonucleotide-lipid complex, as described in WO 90/10448. It is understood that the use of antisense molecules or knock out and knock in models may also be used in screening assays as discussed above, in addition to methods of treatment.


(b) RNA Interference


RNA interference refers to the process of sequence-specific post transcriptional gene silencing in animals mediated by short interfering RNAs (siRNA) (Fire et al., Nature, 391, 806 (1998)). The corresponding process in plants is referred to as post transcriptional gene silencing or RNA silencing and is also referred to as quelling in fungi. The presence of dsRNA in cells triggers the RNAi response though a mechanism that has yet to be fully characterized. This mechanism appears to be different from the interferon response that results from dsRNA mediated activation of protein kinase PKR and 2′,5′-oligoadenylate synthetase resulting in non-specific cleavage of mRNA by ribonuclease L. (reviewed in Sharp, P. A., RNA interference —2001, Genes & Development 15:485-490 (2001)).


Small interfering RNAs (siRNAs) are powerful sequence-specific reagents designed to suppress the expression of genes in cultured mammalian cells through a process known as RNA interference (RNAi). Elbashir, S. M. et al. Nature 411:494-498 (2001); Caplen, N. J. et al. Proc. Natl. Acad. Sci. USA 98:9742-9747 (2001); Harborth, J. et al. J. Cell Sci. 114:4557-4565 (2001). The term “short interfering RNA” or “siRNA” refers to a double stranded nucleic acid molecule capable of RNA interference “RNAi”, (see Kreutzer et al., WO 00/44895; Zernicka-Goetz et al. WO 01/36646; Fire, WO 99/32619; Mello and Fire, WO 01/29058). As used herein, siRNA molecules are limited to RNA molecules but further encompasses chemically modified nucleotides and non-nucleotides. siRNA gene-targeting experiments have been carried out by transient siRNA transfer into cells (achieved by such classic methods as liposome-mediated transfection, electroporation, or microinjection).


Molecules of siRNA are 21- to 23-nucleotide RNAs, with characteristic 2- to 3-nucleotide 3′-overhanging ends resembling the RNase III processing products of long double-stranded RNAs (dsRNAs) that normally initiate RNAi. When introduced into a cell, they assemble with yet-to-be-identified proteins of an endonuclease complex (RNA-induced silencing complex), which then guides target mRNA cleavage. As a consequence of degradation of the targeted mRNA, cells with a specific phenotype characteristic of suppression of the corresponding protein product are obtained. The small size of siRNAs, compared with traditional antisense molecules, prevents activation of the dsRNA-inducible interferon system present in mammalian cells. This avoids the nonspecific phenotypes normally produced by dsRNA larger than 30 base pairs in somatic cells.


Intracellular transcription of small RNA molecules is achieved by cloning the siRNA templates into RNA polymerase III (Pol III) transcription units, which normally encode the small nuclear RNA (snRNA) U6 or the human RNase P RNA H1. Two approaches have been developed for expressing siRNAs: in the first, sense and antisense strands constituting the siRNA duplex are transcribed by individual promoters (Lee, N. S. et al. Nat. Biotechnol. 20, 500-505 (2002). Miyagishi, M. & Taira, K. Nat. Biotechnol. 20, 497-500 (2002).); in the second, siRNAs are expressed as fold-back stem-loop structures that give rise to siRNAs after intracellular processing (Paul, C. P. et al. Nat. Biotechnol. 20:505-508 (2002)). The endogenous expression of siRNAs from introduced DNA templates is thought to overcome some limitations of exogenous siRNA delivery, in particular the transient loss of phenotype. U6 and H1 RNA promoters are members of the type III class of Pol III promoters. (Paule, M. R. & White, R. J. Nucleic Acids Res. 28, 1283-1298 (2000)).


Co-expression of sense and antisense siRNAs mediate silencing of target genes, whereas expression of sense or antisense siRNA alone do not greatly affect target gene expression. Transfection of plasmid DNA, rather than synthetic siRNAs, may appear advantageous, considering the danger of RNase contamination and the costs of chemically synthesized siRNAs or siRNA transcription kits. Stable expression of siRNAs allows new gene therapy applications, such as treatment of persistent viral infections. Considering the high specificity of siRNAs, the approach also allows the targeting of disease-derived transcripts with point mutations, such as RAS or TP53 oncogene transcripts, without alteration of the remaining wild-type allele. Finally, by high-throughput sequence analysis of the various genomes, the DNA-based methodology may also be a cost-effective alternative for automated genome-wide loss-of-function phenotypic analysis, especially when combined with miniaturized array-based phenotypic screens. (Ziauddin, J. & Sabatini, D. M. Nature 411:107-110 (2001)).


The presence of long dsRNAs in cells stimulates the activity of a ribonuclease III enzyme referred to as dicer. Dicer is involved in the processing of the dsRNA into short pieces of dsRNA known as short interfering RNAs (siRNA) (Berstein et al., 2001, Nature, 409:363 (2001)). Short interfering RNAs derived from dicer activity are typically about 21-23 nucleotides in length and comprise about 19 base pair duplexes. Dicer has also been implicated in the excision of 21 and 22 nucleotide small temporal RNAs (stRNA) from precursor RNA of conserved structure that are implicated in translational control (Hutvagner et al., Science, 293, 834 (2001)). The RNAi response also features an endonuclease complex containing a siRNA, commonly referred to as an RNA-induced silencing complex (RISC), which mediates cleavage of single stranded RNA having sequence homologous to the siRNA. Cleavage of the target RNA takes place in the middle of the region complementary to the guide sequence of the siRNA duplex (Elbashir et al., Genes Dev., 15, 188 (2001)).


This invention provides an expression system comprising an isolated nucleic acid molecule comprising a sequence capable of specifically hybridizing to the CA sequences. In an embodiment, the nucleic acid molecule is capable of inhibiting the expression of the CA protein. A method of inhibiting expression of CA inside a cell by a vector-directed expression of a short RNA which short RNA can fold in itself and create a double strand RNA having CA mRNA sequence identity and able to trigger posttranscriptional gene silencing, or RNA interference (RNAi), of the CA gene inside the cell. In another method a short double strand RNA having CA mRNA sequence identity is delivered inside the cell to trigger posttranscriptional gene silencing, or RNAi, of the CA gene. In various embodiments, the nucleic acid molecule is at least a 7 mer, at least a 10 mer, or at least a 20 mer. In a further embodiment, the sequence is unique.


(c) Pharmaceutical Compositions


Pharmaceutical compositions encompassed by the present invention include as active agent, the polypeptides, polynucleotides, antisense oligonucleotides, or antibodies of the invention disclosed herein in a therapeutically effective amount. An “effective amount” is an amount sufficient to effect beneficial or desired results, including clinical results. An effective amount can be administered in one or more administrations. For purposes of this invention, an effective amount of an adenoviral vector is an amount that is sufficient to palliate, ameliorate, stabilize, reverse, slow or delay the progression of the disease state.


The compositions can be used to treat cancer as well as metastases of primary cancer. In addition, the pharmaceutical compositions can be used in conjunction with conventional methods of cancer treatment, e.g., to sensitize tumors to radiation or conventional chemotherapy. The terms “treatment”, “treating”, “treat” and the like are used herein to generally refer to obtaining a desired pharmacologic and/or physiologic effect. The effect may be prophylactic in terms of completely or partially preventing a disease or symptom thereof and/or may be therapeutic in terms of a partial or complete stabilization or cure for a disease and/or adverse effect attributable to the disease. “Treatment” as used herein covers any treatment of a disease in a mammal, particularly a human, and includes: (a) preventing the disease or symptom from occurring in a subject which may be predisposed to the disease or symptom but has not yet been diagnosed as having it; (b) inhibiting the disease symptom, i.e., arresting its development; or (c) relieving the disease symptom, i.e., causing regression of the disease or symptom.


Where the pharmaceutical composition comprises an antibody that specifically binds to a gene product encoded by a differentially expressed polynucleotide, the antibody can be coupled to a drug for delivery to a treatment site or coupled to a detectable label to facilitate imaging of a site comprising cancer cells, such as prostate cancer cells. Methods for coupling antibodies to drugs and detectable labels are well known in the art, as are methods for imaging using detectable labels.


A “patient” for the purposes of the present invention includes both humans and other animals, particularly mammals, and organisms. Thus the methods are applicable to both human therapy and veterinary applications. In the preferred embodiment the patient is a mammal, and in the most preferred embodiment the patient is human.


The term “therapeutically effective amount” as used herein refers to an amount of a therapeutic agent to treat, ameliorate, or prevent a desired disease or condition, or to exhibit a detectable therapeutic or preventative effect. The effect can be detected by, for example, chemical markers or antigen levels. Therapeutic effects also include reduction in physical symptoms, such as decreased body temperature. The precise effective amount for a subject will depend upon the subject's size and health, the nature and extent of the condition, and the therapeutics or combination of therapeutics selected for administration. The effective amount for a given situation is determined by routine experimentation and is within the judgment of the clinician. For purposes of the present invention, an effective dose will generally be from about 0.01 mg/kg to about 5 mg/kg, or about 0.01 mg/kg to about 50 mg/kg or about 0.05 mg/kg to about 10 mg/kg of the compositions of the present invention in the individual to which it is administered.


A pharmaceutical composition can also contain a pharmaceutically acceptable carrier. The term “pharmaceutically acceptable carrier” refers to a carrier for administration of a therapeutic agent, such as antibodies or a polypeptide, genes, and other therapeutic agents. The term refers to any pharmaceutical carrier that does not itself induce the production of antibodies harmful to the individual receiving the composition, and which can be administered without undue toxicity. Suitable carriers can be large, slowly metabolized macromolecules such as proteins, polysaccharides, polylactic acids, polyglycolic acids, polymeric amino acids, amino acid copolymers, and inactive virus particles. Such carriers are well known to those of ordinary skill in the art. Pharmaceutically acceptable carriers in therapeutic compositions can include liquids such as water, saline, glycerol and ethanol. Auxiliary substances, such as wetting or emulsifying agents, pH buffering substances, and the like, can also be present in such vehicles. Typically, the therapeutic compositions are prepared as injectables, either as liquid solutions or suspensions; solid forms suitable for solution in, or suspension in, liquid vehicles prior to injection can also be prepared. Liposomes are included within the definition of a pharmaceutically acceptable carrier. Pharmaceutically acceptable salts can also be present in the pharmaceutical composition, e.g., mineral acid salts such as hydrochlorides, hydrobromides, phosphates, sulfates, and the like; and the salts of organic acids such as acetates, propionates, malonates, benzoates, and the like. A thorough discussion of pharmaceutically acceptable excipients is available in Remington: The Science and Practice of Pharmacy (1995) Alfonso Gennaro, Lippincott, Williams, & Wilkins.


The pharmaceutical compositions can be prepared in various forms, such as granules, tablets, pills, suppositories, capsules, suspensions, salves, lotions and the like. Pharmaceutical grade organic or inorganic carriers and/or diluents suitable for oral and topical use can be used to make up compositions containing the therapeutically-active compounds. Diluents known to the art include aqueous media, vegetable and animal oils and fats. Stabilizing agents, wetting and emulsifying agents, salts for varying the osmotic pressure or buffers for securing an adequate pH value, and skin penetration enhancers can be used as auxiliary agents.


The pharmaceutical compositions of the present invention comprise a CA protein in a form suitable for administration to a patient. In the preferred embodiment, the pharmaceutical compositions are in a water soluble form, such as being present as pharmaceutically acceptable salts, which is meant to include both acid and base addition salts. “Pharmaceutically acceptable acid addition salt” refers to those salts that retain the biological effectiveness of the free bases and that are not biologically or otherwise undesirable, formed with inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid and the like, and organic acids such as acetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, maleic acid, malonic acid, succinic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid and the like. “Pharmaceutically acceptable base addition salts” include those derived from inorganic bases such as sodium, potassium, lithium, ammonium, calcium, magnesium, iron, zinc, copper, manganese, aluminum salts and the like. Particularly preferred are the ammonium, potassium, sodium, calcium, and magnesium salts. Salts derived from pharmaceutically acceptable organic non-toxic bases include salts of primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines and basic ion exchange resins, such as isopropylamine, trimethylamine, diethylamine, triethylamine, tripropylamine, and ethanolamine.


The pharmaceutical compositions may also include one or more of the following: carrier proteins such as serum albumin; buffers; fillers such as microcrystalline cellulose, lactose, corn and other starches; binding agents; sweeteners and other flavoring agents; coloring agents; and polyethylene glycol. Additives are well known in the art, and are used in a variety of formulations.


The compounds having the desired pharmacological activity may be administered in a physiologically acceptable carrier to a host, as previously described. The agents may be administered in a variety of ways, orally, parenterally e.g., subcutaneously, intraperitoneally, intravascularly, etc. Depending upon the manner of introduction, the compounds may be formulated in a variety of ways. The concentration of therapeutically active compound in the formulation may vary from about 0.1-100% wgt/vol. Once formulated, the compositions contemplated by the invention can be (1) administered directly to the subject (e.g., as polynucleotide, polypeptides, small molecule agonists or antagonists, and the like); or (2) delivered ex vivo, to cells derived from the subject (e.g., as in ex vivo gene therapy). Direct delivery of the compositions will generally be accomplished by parenteral injection, e.g., subcutaneously, intraperitoneally, intravenously or intramuscularly, intratumoral or to the interstitial space of a tissue. Other modes of administration include oral and pulmonary administration, suppositories, and transdermal applications, needles, and gene guns or hyposprays. Dosage treatment can be a single dose schedule or a multiple dose schedule.


Methods for the ex vivo delivery and reimplantation of transformed cells into a subject are known in the art and described in e.g., International Publication No. WO 93/14778. Examples of cells useful in ex vivo applications include, for example, stem cells, particularly hematopoetic, lymph cells, macrophages, dendritic cells, or tumor cells. Generally, delivery of nucleic acids for both ex vivo and in vitro applications can be accomplished by, for example, dextran-mediated transfection, calcium phosphate precipitation, polybrene mediated transfection, protoplast fusion, electroporation, encapsulation of the polynucleotide(s) in liposomes, and direct microinjection of the DNA into nuclei, all well known in the art.


Once differential expression of a gene corresponding to a CA polynucleotide described herein has been found to correlate with a proliferative disorder, such as neoplasia, dysplasia, and hyperplasia, the disorder can be amenable to treatment by administration of a therapeutic agent based on the provided polynucleotide, corresponding polypeptide or other corresponding molecule (e.g., antisense, ribozyme, etc.). In other embodiments, the disorder can be amenable to treatment by administration of a small molecule drug that, for example, serves as an inhibitor (antagonist) of the function of the encoded gene product of a gene having increased expression in cancerous cells relative to normal cells or as an agonist for gene products that are decreased in expression in cancerous cells (e.g., to promote the activity of gene products that act as tumor suppressors).


The dose and the means of administration of the inventive pharmaceutical compositions are determined based on the specific qualities of the therapeutic composition, the condition, age, and weight of the patient, the progression of the disease, and other relevant factors. For example, administration of polynucleotide therapeutic compositions agents includes local or systemic administration, including injection, oral administration, particle gun or catheterized administration, and topical administration. Preferably, the therapeutic polynucleotide composition contains an expression construct comprising a promoter operably linked to a polynucleotide of at least 12, 22, 25, 30, or 35 contiguous nt of the polynucleotide disclosed herein. Various methods can be used to administer the therapeutic composition directly to a specific site in the body. For example, a small metastatic lesion is located and the therapeutic composition injected several times in several different locations within the body of tumor. Alternatively, arteries that serve a tumor are identified, and the therapeutic composition injected into such an artery, in order to deliver the composition directly into the tumor. A tumor that has a necrotic center is aspirated and the composition injected directly into the now empty center of the tumor. An antisense composition is directly administered to the surface of the tumor, for example, by topical application of the composition. X-ray imaging is used to assist in certain of the above delivery methods.


Targeted delivery of therapeutic compositions containing an antisense polynucleotide, subgenomic polynucleotides, or antibodies to specific tissues can also be used. Receptor-mediated DNA delivery techniques are described in, for example, Findeis et al., Trends Biotechnol. (1993) 11:202; Chiou et al., Gene Therapeutics: Methods And Applications Of Direct Gene Transfer (J. A. Wolff, ed.) (1994); Wu et al., J. Biol. Chem. (1988) 263:621; Wu et al., J. Biol. Chem. (1994) 269:542; Zenke et al., Proc. Natl. Acad. Sci. (USA) (1990) 87:3655; Wu et al., J. Biol. Chem. (1991) 266:338. Therapeutic compositions containing a polynucleotide are administered in a range of about 100 ng to about 200 mg of DNA for local administration in a gene therapy protocol. Concentration ranges of about 500 ng to about 50 mg, about 1 μg to about 2 mg, about 5 μg to about 500 μg, and about 20 μg to about 100 μg of DNA can also be used during a gene therapy protocol. Factors such as method of action (e.g., for enhancing or inhibiting levels of the encoded gene product) and efficacy of transformation and expression are considerations that will affect the dosage required for ultimate efficacy of the antisense subgenomic polynucleotides. Where greater expression is desired over a larger area of tissue, larger amounts of antisense subgenomic polynucleotides or the same amounts re-administered in a successive protocol of administrations, or several administrations to different adjacent or close tissue portions of, for example, a tumor site, may be required to effect a positive therapeutic outcome. In all cases, routine experimentation in clinical trials will determine specific ranges for optimal therapeutic effect.


The therapeutic polynucleotides and polypeptides of the present invention can be delivered using gene delivery vehicles. The gene delivery vehicle can be of viral or non-viral origin (see generally, Jolly, Cancer Gene Therapy (1994) 1:51; Kimura, Human Gene Therapy (1994) 5:845; Connelly, Human Gene Therapy (1995) 1:185; and Kaplitt, Nature Genetics (1994) 6:148). Expression of such coding sequences can be induced using endogenous mammalian or heterologous promoters. Expression of the coding sequence can be either constitutive or regulated.


Viral-based vectors for delivery of a desired polynucleotide and expression in a desired cell are well known in the art. Exemplary viral-based vehicles include, but are not limited to, recombinant retroviruses (see, e.g., WO 90/07936; WO 94/03622; WO 93/25698; WO 93/25234; U.S. Pat. No. 5,219,740; WO 93/11230; WO 93/10218; U.S. Pat. No. 4,777,127; GB Patent No. 2,200,651; EP 0 345 242; and WO 91/02805), alphavirus-based vectors (e.g., Sindbis virus vectors, Semliki forest virus (ATCC VR-67; ATCC VR-1247), Ross River virus (ATCC VR-373; ATCC VR-1246) and Venezuelan equine encephalitis virus (ATCC VR-923; ATCC VR-1250; ATCC VR 1249; ATCC VR-532)), and adeno-associated virus (AAV) vectors (see, e.g., WO 94/12649, WO 93/03769; WO 93/19191; WO 94/28938; WO 95/11984 and WO 95/00655). Administration of DNA linked to killed adenovirus as described in Curiel, Hum. Gene Ther. (1992) 3:147 can also be employed.


Non-viral delivery vehicles and methods can also be employed, including, but not limited to, polycationic condensed DNA linked or unlinked to killed adenovirus alone (see, e.g., Curiel, Hum. Gene Ther. (1992) 3:147); ligand-linked DNA (see, e.g., Wu, J. Biol. Chem. (1989) 264:16985); eukaryotic cell delivery vehicles cells (see, e.g., U.S. Pat. No. 5,814,482; WO 95/07994; WO 96/17072; WO 95/30763; and WO 97/42338) and nucleic charge neutralization or fusion with cell membranes. Naked DNA can also be employed. Exemplary naked DNA introduction methods are described in WO 90/11092 and U.S. Pat. No. 5,580,859. Liposomes that can act as gene delivery vehicles are described in U.S. Pat. No. 5,422,120; WO 95/13796; WO 94/23697; WO 91/14445; and EP 0524968. Additional approaches are described in Philip, Mol. Cell Biol. (1994) 14:2411, and in Woffendin, Proc. Natl. Acad. Sci. (1994) 91:1581.


Further non-viral delivery suitable for use includes mechanical delivery systems such as the approach described in Woffendin et al., Proc. Natl. Acad. Sci. USA (1994) 91(24):11581. Moreover, the coding sequence and the product of expression of such can be delivered through deposition of photopolymerized hydrogel materials or use of ionizing radiation (see, e.g., U.S. Pat. No. 5,206,152 and WO 92/11033). Other conventional methods for gene delivery that can be used for delivery of the coding sequence include, for example, use of hand-held gene transfer particle gun (see, e.g., U.S. Pat. No. 5,149,655); use of ionizing radiation for activating transferred gene (see, e.g., U.S. Pat. No. 5,206,152 and WO 92/11033).


The administration of the CA proteins and modulators of the present invention can be done in a variety of ways as discussed above, including, but not limited to, orally, subcutaneously, intravenously, intranasally, transdermally, intraperitoneally, intramuscularly, intrapulmonary, vaginally, rectally, or intraocularly. In some instances, for example, in the treatment of wounds and inflammation, the CA proteins and modulators may be directly applied as a solution or spray.


In a preferred embodiment, CA proteins and modulators are administered as therapeutic agents, and can be formulated as outlined above. Similarly, CA genes (including both the fill-length sequence, partial sequences, or regulatory sequences of the CA coding regions) can be administered in gene therapy applications, as is known in the art. These CA genes can include antisense applications, either as gene therapy (i.e. for incorporation into the genome) or as antisense compositions, as will be appreciated by those in the art.


Thus, in one embodiment, methods of modulating CA gene activity in cells or organisms are provided. In one embodiment, the methods comprise administering to a cell an anti-CA antibody that reduces or eliminates the biological activity of an endogenous CA protein. Alternatively, the methods comprise administering to a cell or organism a recombinant nucleic acid encoding a CA protein. As will be appreciated by those in the art, this may be accomplished in any number of ways. In a preferred embodiment, for example when the CA sequence is down-regulated in cancer, the activity of the CA gene product is increased by increasing the amount of CA expression in the cell, for example by overexpressing the endogenous CA gene or by administering a gene encoding the CA sequence, using known gene-therapy techniques. In a preferred embodiment, the gene therapy techniques include the incorporation of the exogenous gene using enhanced homologous recombination (EHR), for example as described in PCT/US93/03868, hereby incorporated by reference in its entirety. Alternatively, for example when the CA sequence is up-regulated in cancer, the activity of the endogenous CA gene is decreased, for example by the administration of a CA antisense nucleic acid.


(d) Vaccines


In a preferred embodiment, CA genes are administered as DNA vaccines, either single genes or combinations of CA genes. Naked DNA vaccines are generally known in the art. Brower, Nature Biotechnology, 16:1304-1305 (1998).


In one embodiment, CA genes of the present invention are used as DNA vaccines. Methods for the use of genes as DNA vaccines are well known to one of ordinary skill in the art, and include placing a CA gene or portion of a CA gene under the control of a promoter for expression in a patient with cancer. The CA gene used for DNA vaccines can encode full-length CA proteins, but more preferably encodes portions of the CA proteins including peptides derived from the CA protein. In a preferred embodiment a patient is immunized with a DNA vaccine comprising a plurality of nucleotide sequences derived from a CA gene. Similarly, it is possible to immunize a patient with a plurality of CA genes or portions thereof. Without being bound by theory, expression of the polypeptide encoded by the DNA vaccine, cytotoxic T-cells, helper T-cells and antibodies are induced that recognize and destroy or eliminate cells expressing CA proteins.


In a preferred embodiment, the DNA vaccines include a gene encoding an adjuvant molecule with the DNA vaccine. Such adjuvant molecules include cytokines that increase the immunogenic response to the CA polypeptide encoded by the DNA vaccine. Additional or alternative adjuvants are known to those of ordinary skill in the art and find use in the invention.


(e) Antibodies


In one embodiment, a cancer inhibitor is an antibody as discussed above. In one embodiment, the CA proteins of the present invention may be used to generate polyclonal and monoclonal antibodies to CA proteins, which are useful as described herein. Similarly, the CA proteins can be coupled, using standard technology, to affinity chromatography columns. These columns may then be used to purify CA antibodies. In a preferred embodiment, the antibodies are generated to epitopes unique to a CA protein; that is, the antibodies show little or no cross-reactivity to other proteins. These antibodies find use in a number of applications. For example, the CA antibodies may be coupled to standard affinity chromatography columns and used to purify CA proteins. The antibodies may also be used therapeutically as blocking polypeptides, as outlined above, since they will specifically bind to the CA protein.


The present invention further provides methods for detecting the presence of and/or measuring a level of a polypeptide in a biological sample, which CA polypeptide is encoded by a CA polynucleotide that is differentially expressed in a cancer cell, using an antibody specific for the encoded polypeptide. The methods generally comprise: a) contacting the sample with an antibody specific for a polypeptide encoded by a CA polynucleotide that is differentially expressed in a prostate cancer cell; and b) detecting binding between the antibody and molecules of the sample.


Detection of specific binding of the antibody specific for the encoded cancer-associated polypeptide, when compared to a suitable control is an indication that encoded polypeptide is present in the sample. Suitable controls include a sample known not to contain the encoded CA polypeptide or known not to contain elevated levels of the polypeptide; such as normal tissue, and a sample contacted with an antibody not specific for the encoded polypeptide, e.g., an anti-idiotype antibody. A variety of methods to detect specific antibody-antigen interactions are known in the art and can be used in the method, including, but not limited to, standard immunohistological methods, immunoprecipitation, an enzyme immunoassay, and a radioimmunoassay. In general, the specific antibody will be detectably labeled, either directly or indirectly. Direct labels include radioisotopes; enzymes whose products are detectable (e.g., luciferase, β-galactosidase, and the like); fluorescent labels (e.g., fluorescein isothiocyanate, rhodamine, phycoerythrin, and the like); fluorescence emitting metals, e.g., 152Eu, or others of the lanthanide series, attached to the antibody through metal chelating groups such as EDTA; chemiluminescent compounds, e.g., luminol, isoluminol, acridinium salts, and the like; bioluminescent compounds, e.g., luciferin, aequorin (green fluorescent protein), and the like. The antibody may be attached (coupled) to an insoluble support, such as a polystyrene plate or a bead. Indirect labels include second antibodies specific for antibodies specific for the encoded polypeptide (“first specific antibody”), wherein the second antibody is labeled as described above; and members of specific binding pairs, e.g., biotin-avidin, and the like. The biological sample may be brought into contact with and immobilized on a solid support or carrier, such as nitrocellulose, that is capable of immobilizing cells, cell particles, or soluble proteins. The support may then be washed with suitable buffers, followed by contacting with a detectably-labeled first specific antibody. Detection methods are known in the art and will be chosen as appropriate to the signal emitted by the detectable label. Detection is generally accomplished in comparison to suitable controls, and to appropriate standards.


In some embodiments, the methods are adapted for use in vivo, e.g., to locate or identify sites where cancer cells are present. In these embodiments, a detectably-labeled moiety, e.g., an antibody, which is specific for a cancer-associated polypeptide is administered to an individual (e.g., by injection), and labeled cells are located using standard imaging techniques, including, but not limited to, magnetic resonance imaging, computed tomography scanning, and the like. In this manner, cancer cells are differentially labeled.


(f) Detection and Diagnosis of Cancers


Without being bound by theory, it appears that the various CA sequences are important in cancers. Accordingly, disorders based on mutant or variant CA genes may be determined. In one embodiment, the invention provides methods for identifying cells containing variant CA genes comprising determining all or part of the sequence of at least one endogenous CA genes in a cell. As will be appreciated by those in the art, this may be done using any number of sequencing techniques. In a preferred embodiment, the invention provides methods of identifying the CA genotype of an individual comprising determining all or part of the sequence of at least one CA gene of the individual. This is generally done in at least one tissue of the individual, and may include the evaluation of a number of tissues or different samples of the same tissue. The method may include comparing the sequence of the sequenced CA gene to a known CA gene, i.e., a wild-type gene. As will be appreciated by those in the art, alterations in the sequence of some CA genes can be an indication of either the presence of the disease, or propensity to develop the disease, or prognosis evaluations.


The sequence of all or part of the CA gene can then be compared to the sequence of a known CA gene to determine if any differences exist. This can be done using any number of known homology programs, such as Bestfit, etc. In a preferred embodiment, the presence of a difference in the sequence between the CA gene of the patient and the known CA gene is indicative of a disease state or a propensity for a disease state, as outlined herein.


In a preferred embodiment, the CA genes are used as probes to determine the number of copies of the CA gene in the genome. For example, some cancers exhibit chromosomal deletions or insertions, resulting in an alteration in the copy number of a gene.


In another preferred embodiment CA genes are used as probes to determine the chromosomal location of the CA genes. Information such as chromosomal location finds use in providing a diagnosis or prognosis in particular when chromosomal abnormalities such as translocations, and the like are identified in CA gene loci.


The present invention provides methods of using the polynucleotides described herein for detecting cancer cells, facilitating diagnosis of cancer and the severity of a cancer (e.g., tumor grade, tumor burden, and the like) in a subject, facilitating a determination of the prognosis of a subject, and assessing the responsiveness of the subject to therapy (e.g., by providing a measure of therapeutic effect through, for example, assessing tumor burden during or following a chemotherapeutic regimen). Detection can be based on detection of a polynucleotide that is differentially expressed in a cancer cell, and/or detection of a polypeptide encoded by a polynucleotide that is differentially expressed in a cancer cell. The detection methods of the invention can be conducted in vitro or in vivo, on isolated cells, or in whole tissues or a bodily fluid e.g., blood, plasma, serum, urine, and the like).


In some embodiments, methods are provided for detecting a cancer cell by detecting expression in the cell of a transcript that is differentially expressed in a cancer cell. Any of a variety of known methods can be used for detection, including, but not limited to, detection of a transcript by hybridization with a polynucleotide that hybridizes to a polynucleotide that is differentially expressed in a prostate cancer cell; detection of a transcript by a polymerase chain reaction using specific oligonucleotide primers; in situ hybridization of a cell using as a probe a polynucleotide that hybridizes to a gene that is differentially expressed in a prostate cancer cell. The methods can be used to detect and/or measure mRNA levels of a gene that is differentially expressed in a cancer cell. In some embodiments, the methods comprise: a) contacting a sample with a polynucleotide that corresponds to a differentially expressed gene described herein under conditions that allow hybridization; and b) detecting hybridization, if any.


Detection of differential hybridization, when compared to a suitable control, is an indication of the presence in the sample of a polynucleotide that is differentially expressed in a cancer cell. Appropriate controls include, for example, a sample that is known not to contain a polynucleotide that is differentially expressed in a cancer cell, and use of a labeled polynucleotide of the same “sense” as the polynucleotide that is differentially expressed in the cancer cell. Conditions that allow hybridization are known in the art, and have been described in more detail above. Detection can also be accomplished by any known method, including, but not limited to, in situ hybridization, PCR (polymerase chain reaction), RT-PCR (reverse transcription-PCR), TMA, bDNA, and Nasbau and “Northern” or RNA blotting, or combinations of such techniques, using a suitably labeled polynucleotide. A variety of labels and labeling methods for polynucleotides are known in the art and can be used in the assay methods of the invention. Specificity of hybridization can be determined by comparison to appropriate controls.


Polynucleotides generally comprising at least 10 nt, at least 12 nt or at least 15 contiguous nucleotides of a polynucleotide provided herein, such as, for example, those having the sequence as depicted in Tables 1-7, are used for a variety of purposes, such as probes for detection of and/or measurement of, transcription levels of a polynucleotide that is differentially expressed in a prostate cancer cell. As will be readily appreciated by the ordinarily skilled artisan, the probe can be detectably labeled and contacted with, for example, an array comprising immobilized polynucleotides obtained from a test sample (e.g., mRNA). Alternatively, the probe can be immobilized on an array and the test sample detectably labeled. These and other variations of the methods of the invention are well within the skill in the art and are within the scope of the invention.


Nucleotide probes are used to detect expression of a gene corresponding to the provided polynucleotide. In Northern blots, mRNA is separated electrophoretically and contacted with a probe. A probe is detected as hybridizing to an mRNA species of a particular size. The amount of hybridization can be quantitated to determine relative amounts of expression, for example under a particular condition. Probes are used for in situ hybridization to cells to detect expression. Probes can also be used in vivo for diagnostic detection of hybridizing sequences. Probes are typically labeled with a radioactive isotope. Other types of detectable labels can be used such as chromophores, fluorophores, and enzymes. Other examples of nucleotide hybridization assays are described in WO92/02526 and U.S. Pat. No. 5,124,246.


PCR is another means for detecting small amounts of target nucleic acids (see, e.g., Mullis et al., Meth. Enzymol. (1987) 155:335; U.S. Pat. No. 4,683,195; and U.S. Pat. No. 4,683,202). Two primer oligonucleotides that hybridize with the target nucleic acids are used to prime the reaction. The primers can be composed of sequence within or 3′ and 5′ to the CA polynucleotides disclosed herein. Alternatively, if the primers are 3′ and 5′ to these polynucleotides, they need not hybridize to them or the complements. After amplification of the target with a thermostable polymerase, the amplified target nucleic acids can be detected by methods known in the art, e.g., Southern blot. mRNA or cDNA can also be detected by traditional blotting techniques (e.g., Southern blot, Northern blot, etc.) described in Sambrook et al., “Molecular Cloning: A Laboratory Manual” (New York, Cold Spring Harbor Laboratory, 1989) (e.g., without PCR amplification). In general, mRNA or cDNA generated from mRNA using a polymerase enzyme can be purified and separated using gel electrophoresis, and transferred to a solid support, such as nitrocellulose. The solid support is exposed to a labeled probe, washed to remove any unhybridized probe, and duplexes containing the labeled probe are detected.


Methods using PCR amplification can be performed on the DNA from a single cell, although it is convenient to use at least about 105 cells. The use of the polymerase chain reaction is described in Saiki et al. (1985) Science 239:487, and a review of current techniques may be found in Sambrook, et al. Molecular Cloning: A Laboratory Manual, CSH Press 1989, pp. 14.2-14.33. A detectable label may be included in the amplification reaction. Suitable detectable labels include fluorochromes, (e.g. fluorescein isothiocyanate (FITC), rhodamine, Texas Red, phycoerythrin, allophycocyanin, 6-carboxyfluorescein (6-FAM), 2′,7′-dimethoxy-4′,5′-dichloro-6-carboxyfluorescein, 6-carboxy-X-rhodamine (ROX), 6-carboxy-2′,4′,7′,4,7-hexachlorofluorescein (HEX), 5-carboxyfluorescein (5-FAM) or N,N,N′,N′-tetramethyl-6-carboxyrhodamine (TAMRA)), radioactive labels, (e.g. 32p, 35S, 3H, etc.), and the like. The label may be a two stage system, where the polynucleotides is conjugated to biotin, haptens, etc. having a high affinity binding partner, e.g. avidin, specific antibodies, etc., where the binding partner is conjugated to a detectable label. The label may be conjugated to one or both of the primers. Alternatively, the pool of nucleotides used in the amplification is labeled, so as to incorporate the label into the amplification product.


The detection methods can be provided as part of a kit. Thus, the invention further provides kits for detecting the presence and/or a level of a polynucleotide that is differentially expressed in a cancer cell (e.g., by detection of an mRNA encoded by the differentially expressed gene of interest), and/or a polypeptide encoded thereby, in a biological sample. Procedures using these kits can be performed by clinical laboratories, experimental laboratories, medical practitioners, or private individuals. The kits of the invention for detecting a polypeptide encoded by a polynucleotide that is differentially expressed in a cancer cell may comprise a moiety that specifically binds the polypeptide, which may be an antibody that binds the polypeptide or fragment thereof. The kits of the invention used for detecting a polynucleotide that is differentially expressed in a prostate cancer cell may comprise a moiety that specifically hybridizes to such a polynucleotide. The kit may optionally provide additional components that are useful in the procedure, including, but not limited to, buffers, developing reagents, labels, reacting surfaces, means for detection, control samples, standards, instructions, and interpretive information. Accordingly, the present invention provides kits for detecting prostate cancer comprising at least one of polynucleotides having the sequence as shown in Tables 1-7 or fragments thereof.


The present invention further relates to methods of detecting/diagnosing a neoplastic or preneoplastic condition in a mammal (for example, a human). “Diagnosis” as used herein generally includes determination of a subject's susceptibility to a disease or disorder, determination as to whether a subject is presently affected by a disease or disorder, prognosis of a subject affected by a disease or disorder (e.g., identification of pre-metastatic or metastatic cancerous states, stages of cancer, or responsiveness of cancer to therapy), and therametrics (e.g., monitoring a subject's condition to provide information as to the effect or efficacy of therapy).


The terms “treatment”, “treating”, “treat” and the like are used herein to generally refer to obtaining a desired pharmacologic and/or physiologic effect. The effect may be prophylactic in terms of completely or partially preventing a disease or symptom thereof and/or may be therapeutic in terms of a partial or complete stabilization or cure for a disease and/or adverse effect attributable to the disease. “Treatment” as used herein covers any treatment of a disease in a mammal, particularly a human, and includes: (a) preventing the disease or symptom from occurring in a subject which may be predisposed to the disease or symptom but has not yet been diagnosed as having it; (b) inhibiting the disease symptom, i.e., arresting its development; or (c) relieving the disease symptom, i.e., causing regression of the disease or symptom.


An “effective amount” is an amount sufficient to effect beneficial or desired results, including clinical results. An effective amount can be administered in one or more administrations.


A “cell sample” encompasses a variety of sample types obtained from an individual and can be used in a diagnostic or monitoring assay. The definition encompasses blood and other liquid samples of biological origin, solid tissue samples such as a biopsy specimen or tissue cultures or cells derived therefrom, and the progeny thereof. The definition also includes samples that have been manipulated in any way after their procurement, such as by treatment with reagents, solubilization, or enrichment for certain components, such as proteins or polynucleotides. The term “cell sample” encompasses a clinical sample, and also includes cells in culture, cell supernatants, cell lysates, serum, plasma, biological fluid, and tissue samples.


As used herein, the terms “neoplastic cells”, “neoplasia”, “tumor”, “tumor cells”, “cancer” and “cancer cells”, (used interchangeably) refer to cells which exhibit relatively autonomous growth, so that they exhibit an aberrant growth phenotype characterized by a significant loss of control of cell proliferation (i.e., de-regulated cell division). Neoplastic cells can be malignant or benign.


The terms “individual,” “subject,” “host,” and “patient,” are used interchangeably herein and refer to any mammalian subject for whom diagnosis, treatment, or therapy is desired, particularly humans. Other subjects may include cattle, dogs, cats, guinea pigs, rabbits, rats, mice, horses, and so on. Examples of conditions that can be detected/diagnosed in accordance with these methods include cancers. Polynucleotides corresponding to genes that exhibit the appropriate expression pattern can be used to detect cancer in a subject. For a review of markers of cancer, see, e.g., Hanahan et al. Cell 100:57-70 (2000).


One detection/diagnostic method comprises: (a) obtaining from a mammal (e.g., a human) a biological sample, (b) detecting the presence in the sample of a CA protein and (c) comparing the amount of product present with that in a control sample. In accordance with this method, the presence in the sample of elevated levels of a CA gene product indicates that the subject has a neoplastic or preneoplastic condition.


Biological samples suitable for use in this method include biological fluids such as serum, plasma, pleural effusions, urine and cerebro-spinal fluid, CSF, tissue samples (e.g., mammary tumor or prostate tissue slices) can also be used in the method of the invention, including samples derived from biopsies. Cell cultures or cell extracts derived, for example, from tissue biopsies can also be used.


The compound is preferably a binding protein, e.g., an antibody, polyclonal or monoclonal, or antigen binding fragment thereof, which can be labeled with a detectable marker (e.g., fluorophore, chromophore or isotope, etc). Where appropriate, the compound can be attached to a solid support such as a bead, plate, filter, resin, etc. Determination of formation of the complex can be effected by contacting the complex with a further compound (e.g., an antibody) that specifically binds to the first compound (or complex). Like the first compound, the further compound can be attached to a solid support and/or can be labeled with a detectable marker.


The identification of elevated levels of CA protein in accordance with the present invention makes possible the identification of subjects (patients) that are likely to benefit from adjuvant therapy. For example, a biological sample from a post primary therapy subject (e.g., subject having undergone surgery) can be screened for the presence of circulating CA protein, the presence of elevated levels of the protein, determined by studies of normal populations, being indicative of residual tumor tissue. Similarly, tissue from the cut site of a surgically removed tumor can be examined (e.g., by immunofluorescence), the presence of elevated levels of product (relative to the surrounding tissue) being indicative of incomplete removal of the tumor. The ability to identify such subjects makes it possible to tailor therapy to the needs of the particular subject. Subjects undergoing non-surgical therapy, e.g., chemotherapy or radiation therapy, can also be monitored, the presence in samples from such subjects of elevated levels of CA protein being indicative of the need for continued treatment. Staging of the disease (for example, for purposes of optimizing treatment regimens) can also be effected, for example, by biopsy e.g., with antibody specific for a CA protein.


(g) Animal Models and Transgenics


In another preferred embodiment CA genes find use in generating animal models of cancers, particularly lymphomas and carcinomas. As is appreciated by one of ordinary skill in the art, when the CA gene identified is repressed or diminished in CA tissue, gene therapy technology wherein antisense RNA directed to the CA gene will also diminish or repress expression of the gene. An animal generated as such serves as an animal model of CA that finds use in screening bioactive drug candidates. Similarly, gene knockout technology, for example as a result of homologous recombination with an appropriate gene targeting vector, will result in the absence of the CA protein. When desired, tissue-specific expression or knockout of the CA protein may be necessary.


It is also possible that the CA protein is overexpressed in cancer. As such, transgenic animals can be generated that overexpress the CA protein. Depending on the desired expression level, promoters of various strengths can be employed to express the transgene. Also, the number of copies of the integrated transgene can be determined and compared for a determination of the expression level of the transgene. Animals generated by such methods find use as animal models of CA and are additionally useful in screening for bioactive molecules to treat cancer.


Characterization of CA Sequences


The CA nucleic acid sequences of the invention are depicted in Tables 1-7. The sequences in each Table include genomic DNA sequence (mouse genomic sequences mDxx-yyy; human genomic sequences hDxx-yyy), sequence corresponding to the mRNA(s) generated therefrom (mRxx-yyy; hRxx-yyy) and amino acid sequences of the proteins (mPxx-yyy; hPxx-yyy) encoded by the mRNA for both mouse and human genes. N/A indicates a gene that has been identified, but for which there has not been a name ascribed.

TABLE 1MOUSE GENOMIC SEQUENCE:mD22-022 (Seq ID No: 1)CGCCCTCGCTCGCAAACCCAAACACTCCCGGCTGCTGGTGCATGTGATCTCCCAGTAGTCGCTCGGCAGAGATGTTGCTGTTGGCCGCTGCCGGCCTCGTGGCCTTCGTGCTGCTCCTCTACATGGTGTCGCCGCTCATCAGTCCCAAGCCCCTCGCGCTGCCCGGCGCGCACGTAGTGGTGAGTGGCCTCCTGTTGCTGAGCTTGCCCAGGACTGCTTGGCCGGCTTGGGCCAACGAGACCACGGTCCCGGAAAGGAACGGTTGAGTGGGGCGGGTTACCTACTGCCTTAGCCCCGGCATTGCCCTGCCCTGTCGGACCTCAGGAACCCGCCCTCCAAGGCGCCGGGCTACAGGGCAGTGTCGTGGAGAAGGCGCCAGCCTAGTTTCCAGGACTCAGGGGCTCTGCTGCTCGCTGATCCCCGGAGCATCCCTGTCTGCCACTGTTTGGATCTTCAGTTTCCCCAATGAGTCAACAGAGAGACTGAGAAACTTTGCCAAGGACACGGCAGTCGGTGACTAGCAGGATAAGGGCGCAAACCCGGATGGGAGTAGCCACAGCCAGGGAATCCTAAGGAGCCCACAGCAAGGAGGGGGTCTGGGCCTCTGGGGCTGGCCCAGGCAGCTGAGACTGTAGGGTGTCGTGTGCAAGTGACAAAGAGCCCCCAGAGGCTTCTAGGAAGTGATACACCTGAGGGGTGGCCTGGCAGGTTTGGCCAGCAGGCTTGTCTCTGAACTCAGCCAGGGTCTGCTGAGTACTGCTCAAGTGCAGTCCTTTCTGGCGTCAGAAGGAAGAGCTAACCAGCTTGATTAGAAGCTTAAGATGGAAGGAGATATGAGTGGTTTGGTTTGTTAAAGTCCGGAAGCTCGCACGTTCCTATGTGCAGGCTTGGCTATGCCTCCACCCCGCCCCCACAGCTCAGAGCCTCAACTCTGGCATTTCTCCTCGGTGTCCTATATAGACCCAAAACCCGAGGCACAGTGAGGCGAGGAGTTGCGAATAAGGACAGCTAGTATCCAAACCGGCAGCACGAATCTCCTTGGTGCCCTTAGGTGACTTACATGAGTGCATCCAAGTAAGTCCCCACTGCGTTGTTACAGGATAGAGTGGTTATCTTAGTATGATTTATCCCAAACAAGAATTTCTGGATGACAACATGTGTTTCCATTAATTTGTCTTTTGTAAAATTACTGATTTATTCCCAGCTGCTGCTATGCATGATGTGGAAAGAGTTATTAGAAAAAGCCAAAGTTTACAATCATGCCAAGTTGCTAAAGTTTTACATCCACAAAATCGTGACTAAAGCAGTTGAACTTGCCGGCTGAGGAAATGGCTCAGTTGGTAAAGTGCTTGCCGTGCATCATGCCCTGAGTTAGGGTCCCTAGCACCCACATGCTCACTGGGCCTATGCCTCTAACTTCAGCACTGGGGCCACAACCTGTGGATCCCTGGAGCTCACTGGATAGTTTGCCTAGACGCACGAATGATCTTCAGGTTCAGGGAGAAGCCTTGTCGCAAAAATTAAGGTGCAGGGTGACTGAAATGCCAGACACTGCCAGCCTCTGCACAGGTGCACCTACATACACAACGCTGAATCAACTTGTGCTTGTATAGCTCAGCTGTGGGGCAAGGGAGGAGAGCCAAAGTCAGAATGAAAACTAATTCGACAACTACAAGGTACTCACAACTACCCTTGGTACTTGTTCTTGTGTCCCCAGTCCCCGGCTCTTTCACAGAGGAGGTTAGGGCTGTTTCAATAGACGCATTCTTTTTCCCAACATATTTTTATTGATTCTTTGGGAACTTTACATAATGCACTCCAAAACACTCACTTCCCAGCCCTCCCAGGATCCTGCTTTAATACAATAAAAAATAATTACCGCTATGCATGTATGTATGTTTACTGGTATAAACAACATAGCATGGCTTATTCATATGGTGTCCCTATCTGCCTTTTTTAATATCTGAAGAGTAAAATGTGATTTAGTTGTGATCTGGGATCAGGAGAGTGAGCCAAGCTCTTTGTTTTTAGAGCAGTTCACATACGCTGGTGCTGTGGTGTCTGATCACAGCAGCAAAGCTTTGCTGGTCTTCTCATCCAGTAGATGATTGTTCAGTGTCCCTCCTTCTGGATGACTGAGAGTAGTGCTCCTAGCAGCAGGAAAGTTGCTGGTGCCCTTAGTAGGGCCTGTATGCTGCGCTTAAAGAGACAGTATCGTTTAAATGGTATTTGTAGTGATCAGTAACAAGGAGTGGTCAAGGAAGGGAAAGTAAATGGTTATCTTCGGGGCCCTCTGTTTAGATATAGTATACATTTAACGTTTTCTCGGCCATTGTGAAAAACCCACGCCAGTTCTTAGAGCATCCAGAAGAACATATTCCAGAATTAGCCTAACTGTATTCTTATATGCCACTCAAGACTTAGCTGCGTTGGCTAGATCCCTTTGAATGCACCTTGATCTGAAAACCAGGTCTCACTCCCAATGTGAGAAAGTGACACTGTTTGCTTTCCTGAAACCCGCCCTGGCTTTTGTTCACATAATACATCAGAGCATAAAAGATGTCTCAGTAACCTCATTCCTAACTCCATCAGCTTTCTGAACAATAAATAGGGAGACTTTTATTTGTGAGCTTTGACGTTTTGTTTTGTTTTGGTTTTTTGTTTTCATGGAAATGACATAGGAGAACATTCTGCAAACTGAGGAAAGTATTTATTGAGTGCCTGCTTGTGCAGGGGCCTGGCATGGTCTGTGATGAGTGAGACAGGCTGGCTTGGTATTGGTCCATAGGAGCCATGAGTTCAGCCAGGGAGCCAAGATATATCCAAAGTGAGTGCAGACTACATGGTGACCAGCCAGGAGGACTGACTGACTGATGTGTTCAGGAAAGGTTCCCATAGGGCGTGGGGGATGTGTGGGGGGATGTGTGATCCGGGGAAGATAAACAGCTTAAGGCAGCATTATAAAGCATGTGAGGAAATGTTTTAGAGGCTCTGACAAGTACTATGAGGAGTAAAAGTTCATAAACCAGAACAGCCCGTAAGATAGCCTGATATCAGAAGCCACGGAGATAACACTCAGCCAAGGCAACGTGTATCCTTCTATAGTCATCCTCAGCAGACATTTGGTTAATGATCTCCCAAGCAAACCTCTCCATTAGATCCAAGGTGAGACTACAGGGAAGTGACATATTCTCAAGAACACAGAGAGACACATCTATGCTTGGAGGGTTTCATGGCAATACGAACATTACAGTGTGGGAGATGTTCTTTCTGCATGGCTTTAGAGTAGCAAAATATTCAAAGTAATCCAAATGTCTGACTGGAAAGGAGCTAGGTTTTGACAGGAGAGATTTTTGTTTTGCTTTTGATACAGGGTCTTACCGTATAGCCATGCTGGCTTGGAATTTACTGTGTGGGCCAGAATGGCTTGGATTCGGACAGATAGCCTGCCTCTGCCTCCTGAGTTCTAATATTAAGGTGTATGCCATCACTACTATGCCTGGCCTGGATGGAGCTCTTTAAATACAGTATTGTGAAGCCTTGTAGTTTTCAACGTTGAAAGGATATTCTTTCTTTCTCTCTGCTCACGTTTTTACATAGACTTAGACTTACATAGATGTGCTGGAAGGAAATGAGATTCGTTTGTGTTTGTAGTCAGCAGCACATAATGTATTATTTCTTAGCTAAAATTGTAGGGCACGTTTCCTTTGGTGACCTGAAACGATTTTAGATGAATAGTTTATAGCTCAGCACGGGGGGGGGGGGGGGGCTAGGAGGCTAGGAGGCTCTGCTGAGAGTGTAATCTTTGATGCTTACACTGCATTCCAGGTGACAAATGTGGTATGAGGAGGTTGTGGTTCTTGGAGACGCTTTGTTCCTGAGACAGAGCCCCATGTAGTCCTAGCCAATACCATGAAACTGTCCGTGAGATTGAACGACTTCAACCTTGACCTCCTCATCCCCTGCAGACACGCTCCTGGGGAATTTTTAAAACTCAGAATTATGTCATAGTCCTATGCAGTACTGGAGATCCAACCTGGGGCCTCATGAATCCTAGGCAGGTACCTGCACTGAGCTACACCCTTACTACTCCCAACACAAGTATTTCAAGAAGTCTCTGTACAGAGGAGATATGGCAAGTGCTAAGATGGTCTAAGATGGTCTTCCTGATGTTCTTCATAGGTCACAGGAGGCTCCAGTGGCATTGGGAAGTGCATTGCTATTGAGTGCTACAAACAAGGAGCATTTATAACTCTGGTTGCACGAAATGAGGTAAGCGCTCTAGACTCCTCATGACAAACTCACTAACGCGGGAAGTCCAAGAGACGGGTCTTATCTGTCATTTCTCTCTGTAACTTGATGATGACATGATAGGCATCTTTGGCAGAGTCCCCATGCCCCAGGAGAGTTTCATTCTTTCCAGTATGTGTAGCAAAGTAGTTTTTCCTGTTCTAAGCAATCAGGGGTCTGTTTTTCATTGTATTGGGGTCTGCCGTCTTGCCAGAATTGCTTTCGGAGCATGAAGCTATGACTGAAGATGCCCCTTGTTCCTCTTCAGGGTCTGGAGCAGAGACCCCGGCTTCATGGTCAAAAGGTTGGCCTTGCTTGCTGTGGAGCAGATAGATACTCTGTTGAGTGATGAAATGAAAGAAGAGGGGCTTGGGGTGTGCTCAGTGGGCTCAGCACTTACCCAGGGTGAATGAATCAAATCCACAAAGCACTCCAAGAAGGTGCATGGGAACCCTAGCCTTAGGGAGGTGGACGCAGAAGGATCAGAAGTTCAAAGTCTCCCCCTGCTATACAGCAAAGGAGAGTCTTGCCTGACTTTCATGAGACCCTGTAATTCAGGGACAGGGAAGAAAAAGAAATGAGATGTGCTTGAGGGGTTAACTGTCGACATAGAGCGGTTGGTTGAAAAGGGGCTAGTGGAGAAGACAGGCTAGAAAGGATCTCTGGAGAAAATACAAAACAATAATGATCCAGAACTAGGTTAAAATAGCCATCATTTCCTTAAAGAACAAGTAAATGGTTTTTAAAAGAAATTATACAGCCAGGCGTGGTGGTGCACGCCTTTAATCCCAGCACTTGGGAGGCAGAGGCAGGTGGATTTCTGAGTTCGAGGCCAGCCTGGTCTACAAAGTGAGTTCCAGGACAGCCAGGGCTATACAGAGAAACCCTGTCTCAAAAAACTCAAAAAAAATTATATATATATTATATATATACATATATATATATATATATATACACACACATACATACATACACACACACACACACACACATATATATATATTATGGCTTGGTTGGACACACTTTAAGGTCACCATACATGAACAGAACAACAGATTTAGGAAAAGGCCACTTTTGACTTTTTAGCAGGGCTAGAATTTGACAGTGAGTGAGTGGGCGGGGACTGGTGTCAGAGCTGGAAGGAACTTGCAGGACCGTGTTTGGGCTGGCGTCACAGCTAGTGGGTAGGAACTCATGCACAGCCTGGTTGGAGTGAGTATCCAGAGAGTTTTCTAGCCTGAAGATGTTCTTTAGTTTGTCATGTAACTTTTCATTGCAGTCTTGAATTCATTTCCCATCATTCGATAGCATTGTACTATTTTGTCATGAGCATTCATGTTTGTAAATTCGATTTGTTCTTTGAAGATACCTACTGGCCCACCCCCACCCCTCTATGAGACAAGGTCTCGAGTATCATGGGCTAACCTGGAACTCTGTAGCAGAGGATATCCTTGCCAGATACCTAGGTTCCTCCAGGCTTGGTTTTAGCCTTTCCAGGGATTGACCTCACGGTGCCATGCATGCTGGGACCTTCTTTGTTCTTCTACAGTTCTCAAATTTTATTTAAATTTATGAAAAATTAAGGTTCTGTAAACTCATCTGTTTTTATGAGAATAAGCAAAACAAAATGGAGGACATGGGAAAACTTTGCAATTATCTGGGTAGGTTTGTAAGTCTGAGATATATTTTTGAAAGTAACCAGATGTAGATTTTTCTTTCTCCTCTTTGTAAGAAGTGATTGATTTTTACTCGATGTTGCATTGAAAGGAGTAAACTGCTGATATTATCTAATAAAGCCCTCCTGGTGTGGAGTCAGCTGCATGCCTTTAGCCTTCCAGAGCATTTGTGGTCGGTCATGTGCTTATGCTGTGTCCCCGCTCAGTGGTGGGAATGAAAATATCTGTTGGCGTGGACAGGCTGACCAGCAACACTAATGCTGCTGAGAGGGATTTGAGCTTGCTTTCTTCTTCTTCCCATTCTCTGCAATGGACTTAAATGAACCCTGCTGTGACTTACCTGGGCTCTTAGGTGTTTTGCCTCTTTCTTCCTCAAGCCCACAGCTCTGATTTATAGAATGCAGTGTCTGTTCAAATGTTGCTTTTGCTTTTCTTTTTAACAAGTGCAGACAGACATAATTTTTTTCTGTATTGCTTTTAGGACAAGCTACTGCAGGCGAAGAAAGACATTGAAAAGCACTCTATTAATGACAAACAGGTAAAGTGGGGCCGAAGGAGGAATTTTCTTTCCTGATAGACAGTTGTTTAAAGGGGAGGAAAGATGTTACTTCCACTGCAACTGGTTCACTGAAGGCATTTATGGTTTTTCCCAATTAAAATACATTTTAGGCCGCTTTCTAAAAGATGGAATTATTTGAAATGACTAGAATTCAGGTCTCTGTACAGAAACCAGATGGTATAGACTATCACACATACCTGAAAATAGCCAAGCAGCGCTGTATGAGAAAATGGTTTCGTTGCAATTACTCAATTTACACAACGACTTAGATAGAAAGGATGTTTGAAAAGATGTTGTATGATTTGGGGTACTAAACTGATACAGACACTGTAATGTATATTTTCATGTGCAAGTCAGTGACTGGTTGACTACTACAGATCCACCATCTAATCTAAACAAATGGAAATTAAAGGACTTTCTGAACCCTCTCTCCTGCCTTTGGGCTCATTACCAGCCTCTCGTTCTTAGAGGCCACCTTAAGCCCGACTCTGATGTTGTTGTTCATTCATTCTTTACTTTTCTTTAAGATTTTACCGTCTCTGGTAGTGTGTATAGTCTTTTGTATGAGTGTGTGTGTGCACCTGTGTGTACAACGGTCCTGATATGCATGCACATACGTGCACATGCTCGAGAAGCCACGGGCCAACATTGGGTATCTTCTGTAATCTCTCCATATTTTTTTTTTTTAAATAGGCTCTTTTGGTGAGCCTGAAGCTATCCTTGCTGGGGATCTAAACGCAGGGCCTCCTCACGCTAGCACCTTGCCAGCTAGTCATCTTAGCACCTAAATAGTGCGTGTGCGTGTGCGTGTGTGCGTGTGTGTTTGTGTGTTTTCTGTATCCTTTTGAGCTTTGGCAGCATTCCTATGTTTCTGAACTGCCTTAATGAGACCTCGCACACAGTATGTAGTTATGCTTAAGACACCCACTTCCTGAGTTTTCACAAAGTTGTGCAATCATAATCACAATCAATTTGGAAATTGTCCCAACCCTGAAGTCTCCAGACTGCCATTAGCAGCCACACCCATTCCTGCCCTGCCTCTCCTAGCCCTAGCCIAGTACTAATAACCTTTATAATTTGATAGACTGATGGACATTCTTATGCAGTGTCCTGCAACCTTATTTCTTTATTCTATATTATTTTTAAAATTCATCTGTGTTGCTGAATAAAATAGCTCATGTGGTCTTTTCTTTTATTTATTTATTTATTTATTTATTTTTCTTTTTGAGATTCTTTTATGGGTGTGCTGTCCAGCTAGACTCAAATCCCAGGACTGTTTTAGAAAGTTTTAATCAAAATCCGGGATTTCTACCCTGCCTTTGATCATTCAGTTCCCAGATAAAAGACACACTTTTATTATTTACAACAAGCTTTAAACAACACAAGAGCTGGGCAGATATCTGCCTTCCCTGCTATAAGAATCTACTTTCCTATTTATAACCCCGAGTTATTACTTACTGTGCTTTATCTGGGCTGCTCCCAGCTTCAGTTGGCCAGCCTTATAGCTGTTTTCTTGACTCCTAACCCATAGTGTCTTTCTCTTCTCTTTCTCCTTCACTTCTTCTTCCCATCAGAGGTTCTCCTCCAACCCCCAAGCCTTGGAACCCTAAACTCCACCTGAGTCTCTTCTGCCCAGCTGTTGGCTGTCAGCATCTATATTTACC2ATCAGAAATAACTTGGGGATAAGGTCACATTAGCATCACTTGGGTCTGAATGTGGACTCCTCTGGGTCAACCAGGTCTTGAGGAACTAGCAGTATTAGCATTAGAATACAAGCAACATCAGACCAACCCCTACACAGGACTCAAATGATTCTCCTGTCTCAGCTTGTTAACAGGATTGCTATAGGCATACATCATTTTCCTACATTTACTTAAGTTTATTATTGATATATATCATGTAGTTGTATGTATAAAGTACTTTCACTTACCTGTTCTGTCATTGATAGCTATTTAATTTGCTCCCATATTTTTGTGTTTATTGCTGGTTGTTGTCATGGCAGCTTTTCTTTGTGCACATGATCAAAATGATTCTGTTGCTTTGGGACCTTTGACAAGGGAAAGCAAAGTTGCTCAACTCTTAACGGCTGGGAAATGGGGACGGGGGTTGGGGAACTTTCCTCAGTATCTTCTGTGGCCTTGAATGGCATACCTTAGGGACCTAAATTCTCTTTATTATGCCCTGCCTTTTAAAGGTTTCACTGCCTTCCAATAATGCCAATGTACTAGCCCTTTAACATGTTGTCATTGGGAATACAAATTTTAGTACGAGACATTCCAGATGCCTGCCTGTTTGCTCTGGCACCCATCACCATGTCCCTTGCCACAACCCCATGTAGGCATTCTGCTTTGTGATAGGCTGTTTTTTGGCTGCCAGTGAAAGAACCCATTTAAGCTAGATTAGAGTGTATTAAAGGCAGGTTTATTGGGAAGCTGCATCCAGAGTGGGAGAAGGAGAAGGGGAGAGAACATGCAAAATGTCTAGATTATATAGAGAGGAGCCTCTAGGAGAAGGGCAGCCCAGCTCCTGGGTTGAAAAATTCAAGGTTGTGGGCAGGGTATGTCAGGTAGGGACTGAGGGATGCTGGGAGAACCTAGAGGCCAGGTCTGCTGTGCTATGTAAAATATGCACCTTAGTCTCTGTTCCAGGGTCCAGAACCAAACATCTCAGTCTTTTGTTGCTTATAAAAGAATAAGAGACTCCATAATCATACATGACTGCTTCCTGCTGACACTGGGGTGCAGTTGTGAATGTGAGAAAATGCTGGAATGTGGGGCAAATCCAGGAAGAGCTGATTGTCTCACTGCCGCCCAGGTTATGGGACCATCTCAGGGTAGGAGTGGGTAGGCCCAGTTGAAACAGTCTGTGAGGCTGGGGCAGAGCACCTGTGAGTAACTGTTTTGGAGCTCTCGTGGATGCAGATTCTGAGAGAACACCTGGATGTTGGAGACAGAAGATAAAGTTTAGGGAGAAAAACTTCTGGGGGGGGGGTTATACGTTTAAAACTCTTAGGCTCATGGTTGTGGGAGTTGGAGAAGGGGTGGGGTGGGGGCAGGACCAGGGATAGGGCCGGTGGAGAAGGAAACAGGCTGTTAATTGACAGTACTTATCTGGAGTCCATTTGGCTATGGAAGGTGGATTTGAGTGGATTCCCTGAAGCTTACAAGAATCTTTTTAAGTTTACAAAAAGATAAATCCTCTACAACTTCATTTATCCACTTCAATACCCCTTCCTAGACCTTCAAACAGTTTCTTAGAAGCCTTATATATCCTCAGATCTTACGTAAATGTTTCCTATCCAGTTATTCACCATGAGACATGGATGGTTGATCACTAGATTTAAACCCCTCAGAAATCTGAGAATGGTGCATCTAAATGTCCTATGTGTCAGTTAGAATGACAGAGTTACCCATTACCCATTATACCACTAGGTTCCTTTTACGTCGATGGCTTTGTTGAGGACACAGGTCCAGGGCAGGATTCATCTTAGGCTGCCAGGCCCAAAAAATCTGGAAGGCCTTCCTGTGGAGGAGAAACTTGGGAAACTGACCTTGCTTTGACTTAGCCAACATGAGACATGTCTGGTGTCCCTCTTTGTACACAGTTCAGGTCAGACCTCAGCAGTTTAGGCAATGGAGCAGCCTTTCTCAATGGTTATTGTACAATTCAGGTGGAGTCCTCTTGTGCCTGGATCTTCTTGGAGACCTTGAGGGTGTCACTACTAGGATTGGGGAGTCTCTATCATTGTAAGCATTAAGTTTAAGGTTTTAAATGTCATATTCAGCAGGTCTCTGACAGGTTTGAGGCCGGTACCTACTAAGCATATCTGCGTTAGTCAGTCTATGTCTGTTTCTAGTTATCTGTACACCTAGCAAACATAAAAAAGGAGGCTAAATAAAGCTTAAATAATTAACTGCATCATTTCTCAACATGACTTTAGTGATGCCCTTAAGAAAGATGGTGGTGAAGCCATAATTCAACCCTCTTTATTACAAAGTCAAGATGGTGACCAGTTGTGCTGTTTACCCAATGTGTGTACATTGTTAGTTCACCATCACTGTTGTAATCAGTATTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTACAGGAAGGAGCGGGGAGAGGTGGGGAAGTCTGAGCTAGGTGGCACCTGGAGCCTTGTGCTCAGTGTGGTGAAGGGAGAGTGGGAGAACACAGCCTCCAAAAAGCTGGACACAGGGAATTCAGACCAATTTGAATAAATTTTTTTTTTTAGATCCCATGGCACCCATCATCCCAGCGTTCACTGGGAGATCCCAACACTATTGAATTAGCATCCCAATTCATAGTCTGAGATCAAATGGTTTATGCAGAAGTGTAGTAACCTCAGATAAGGCATGTCTGTATCAAAGGTTCCCCCAAAACAAAGACCTGGCCTTTGTTCAGATGGGGGGAACTCTAACGTAGCTGTGACTCAGCAGAGAAAGCTCCGAGGATCCTAGACCCAGATAGGAAATAGCTGGCGATGGGTAGCCACAGAGTCAGAAGAAATGATGTATTTCAGTGGAGAGGGCTAGAAGAACAGATTGGTTCCCAGATGGCCAGGAAATACCAGGTCCTTCGAACTGGGGACTCAACTTCTCTCCAGTTCAGCGACATCTGATAGGTTATTTTTCCACCACCGGTGAAATGAGCCAATTTAAGCCAGATTAGATTAGATTAAAGGCTGGTTTATTGGGAAGCTGCTCTCAGGTGGGTGAGTTCACTGGCCCGGAGGACCAAGGCCAGGGAAATCGCCATAAGGACAAGGGAAGAGAGGGACAGGAGGGGAGGGAGAGAGAAAGAGAAGCTGCACACACAGAGAGGGAAGAGAAGAGGAGCCTCTGGGGAAGGGCAGCCCAGCTCCTGGCCTAGAAAGTTCAGGGTTTGGGGCAGGGTATGCCAGGTAGGGACTGAGGGATGCTAGGAGAACCTGGAAGCCAGATCTGCTTTGGTATGTAAAATTTGTATCTCCACCCCCGATCCTGGGGTCAGAAATGAAACACTTCGTAGGTGTACGTGGCTAAATTGGCCATTATTAGAAAGACTTGGTTTTACTATTTTTTTTTTAAATACCGTTACAAATAGTTTTGGTAGACCAACATTTTGGCATGTGCTTATAATCTAAGTAATCTCAGTATTTGGAAGGCTGAAACCGGAGGAGAGCTGTGAGCCCAAGTTATTCTAGACAGAAGTCCAAGACCGTGTGTGTAGGTTAAAATAGCCCGAAGATGTCATTCTGTCCTTCCACCATGTGAGTCCCAGGTGATGAGCACCCTTACCCGCTGAGCTGTCTCTCAGGTCCTGATCCCATTTCTCCTGTTTTCTTCCTTTGAGCAGGTGGTGCTGTGTATCTCAGTTGATGTGTCTCAAGACTATAACCAAGTGGAGAATGTCATAAAGCAGGTAAGAGGAGAGGTGCTTTCAGTTTCACTGCCTGACTCTGCTCAGCTCTCGCCAGGAGTTGACAGCTCTTCTCTATAGGCTTAGTGGTTCCATGGACTTGATTGACCTTATCTTTCTGAATGATGAATCTTCCATTCTCTGATGTAGTGTTTGGAATGATATGTAATGTTATGGAATATTCCTCCAGGCACAAGAGAAGCTGGGTCCTGTGGACATGCTGGTCAACTGTGCAGGCACCTCTATGTCAGGAAAGTTTGAAGAGCTTGAAGTTAGTAGTTTTGAGGTGAGTCACAGTGGTATCAAGATGATGTCTTCTATTTTAAAACAGCCCTGCCAAGCCAAGAACTCAGCTACTAATGTACTTCAACACTGAGGAAATGGGCATTAGGTGTGAACTCTTAAGTGCAACGCCTTTTGACCTTGGCAATACGTCATTCTTGTCTTTAGTGTCCTCTTTCACCAGGGTGATAGGGACTCTGAAGTTAAACTGCTCTGCTATCTATCTTATAGGAGGTGTGACTGCTGGACCAGTGTCAGAACTATCTTCTCACAGGCTGTAGTCAACCCCATATACTCAGAGATACACACAAGGCCTACAGGAGGATCAGAGGGTGGTAAAAGGTAGAATGGTAGGACCTGAGTGTCTGAGTTTGTCTGAGACGCCCTGTCACTGTGCACATCACGCTGGCCCAGCCTTCTACCTCAGCTTCCTGAGCACTGGGATCACACATCTCTGTCACTGTGCCTAGTGTCACCGTGCCTAGTGTCACCGTGCCTAGTGTCACTACACCTGGCACAATTGTTTGTTTTACAGTGAATAATTCAGAGGCACTTAGCAAATTGTGATGTTGTGTAACTATCTAATTCTAAAACATTTTCATCTCTCCAAAAGAATACCCTATACTTTAGTCAGTATTTCTCATTAACCCAAACCCTTATTCTAGCCAATGGCTACCCCTAATCTGTGTCTGTCTTGCTGAATAATGGAGTCGTGTGCAGCGTGCGTGCCCTCCTGTGCCTGGCTTTCTCCCATGCTGAACGCCCTAAAGGTTCCTCCTTCACACTGACGTGTACACCGGTGCTTTGTTTTTCTGAGTTGGTAACAGTCCAATTGTGTGAAGAGACTGCAGTGTGCTTGCTTGCTTATCACCCCTGAATATTTGGACCATTCTTACCCACCCGGACCAGCCCAGAAGCTCCAGGTATCATTTGAGCCCTTGGAGGTTGTGATGCACAACCCTGTGTTGTAGTTTCCCTGTCACCAGTCAACACTCAGGTTTCCATGTCTTGCCAAGTGTGGTACAACTTGTAGTGTGTTCTCCAGCTTTAGGCTGTTGTTGCTTTTCTTTTCCCTCTGTTGTGTTCTCTCGGGGCTCTTAGCTGGATGAAGTGGCTCATGCGCATAATCCCAGCTCTTGGGAAACTGAGGCAGGAGACTAAGGTTGAGTTTAAGGCCAGCCTGAGCTATGAAGTAAGTTTCAGGCCCTCGTGAGATACAATATGAGACTCTATCTCCAAAACAGAGAGACAAATGTACTCCTTACTGGTGTTTTATTGAGTTCTCTCAAAAGAACTGGGGTAAGCATGGAGTTTTGTTCATTCACAGGTTCTTTTGGGGGGTTCTTACTACTAAAGCAATGTCATGAGGGGCTGGAGAGATGGCTCAGCGGCTGACAGTGTTTGCTGCTCTTGTAGAGGACTGAGGTTCAGTTCCCAACACTCTGAGAGGTCACATCTGTAATTCCAGTACCAAAGGATCCAGTGCCAGCCAGGCACACACATACATGCACGCAAGACACTCAAATGCACATAATAAAAATCAAAGTTTTAAAGGCTAAAACAAGGCAGTGATATTAAAACATTCTAGGGGAAAACAAAAACAAAAAACAAGCAAGAATCCTGGCTTCCAAACACAATCAATATTTTCAGTTCTCTTTGCTTTTACAAAATAGAGTGGTAAGAATTACTATCTGCACATATCCTGTCTTCTACTTTTTGAAAACTCATAGCATAAATTTTTTCCCTCACTCTTGTGTTTTCAGTTCTCTTTCCTTAAAGTTTCTTAGTATTCTGCCACACTGCTATCATGGTTGTGTATGCTCTGACTGGGCTGTGTAGCTTCTCAGGGTAAGGAGAATAGCCTTCCGGTATATAAACCCGTCACTGTGTGGCCTTCCGGTGTATAAACCCATCACTGTGTGCCCTTCCGGTGTATAAACCCATCACTGTGTGCCCTTCCGGTGTATAAACCCGTCAGTCACTGTGCATCCTCAGGTTCTCAGCGTGAACGTGGGGTTCTGGGATGAGAAGCTGGGACTGTCTCTGCGGGCACTTTCCAGCAAATACCGAGTTCTTACTGTGCAGGGCAGCAGGATCTGTGCTTGTACTTAGCTTGTGTTTTCCCGTGTAATCCCTGAAGCATCCTGAGGTCATGCTGAGATTAACCCCATTTTCACCTGAGGAAATGCCCAGCTGAGAAAAGTCTCACAAGATCAGGGGTGGGTAGTGGCATGAAGGCACAGCTCTACTGTTAACTGGTCCCACGTTCTCTGTATAGTCCTTGTCTAGCTTAGAACTAACAGGGCCAAAGAAATATTTTGAAGCTTTCTCCTAAAACTGTCCTTCAAGAATTATTACCTATAAGAACTTAAAAAGATAGCTTAGGGATTAAGAGTCCTGGCCACTCTGGCAGAGGACCCAGGTTTAGTCACCAGCAACTTACAGCTGTCTTTAATTCCAGTTCAGAAGATCCAGCGCCCCATTCTGGCCTCTGGGCACTGCACACACATGGTACACAGAAATATTTTCAGGCAAAACCCTATACACATAAAATATCGTTATAATGCATTACCTACAGTAAGTACTTTTCTAGTAGAACACTGATTTTGACCATTTGTGTGACCATTTGTGCATGGTTGGAGCAGAGGTTAATGTTGGCTGTTCGTTCTCGTTCGTTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTGTCACTATTTTGGTTACACTGGCTGAGACTGTCCAGTAAGCTGCTGGGATCTGCCTGTTTCTGCCTTCTTGCTCCCGGTGCCTGGGTTAGAGGTGTGTTCCCTTATGCCCCGCAGAGTTTTTGATGGGGATCCAAACTCAAGTCCATATGCTTGCACACAAAGGACTTTCCTAACTCAACCTTGTGCCTAGCCCTAATTTTGACATTTATATCAAAAATGGAACTGCTGTCACTATGAGAATTGTCTTCAAACTAGTCTCCAGAGGCTAGGTCCTGAGTGTCATAGTATCTACTACGTTTGTTCACTTCCCCATACAATATTCAGCAAATCTCCTGCACCCTGGCTCCCAGTCCCCTGGGTTTTTTTTTTTTTAATTTAGTTGTTATTCTATTGCTGTGAAGAGACACTGACCAATGCAACTCTTATAAAGGAAAGCATTTAATTGGAGCATGCTTACAGGTTCAGAGGCTCAGTCCATTATGATCGTGGTGGGAAGCAGACAGGCATAATGCTAGAGCAGTAGCTGAGAGCTTTATATCCTGGTCCACAGGCAAGAGAGAGAAGAGGGAGGGGAGGAAGGAGGGAGGGAGAGGGAGAGAGAGAGAACGAGAACGAGAGAATGAGAACACGAACACAGACAGACACTGGGTCTACTGTGGACTTTTGAAACCTCAGCATACCCCCAGAAACACACCTTCTCCAACAAGGCCCCCCTACCTAATCCTTCCAAACTATTAAACCAAATAGGAACCATGCCTACAAATATATATGCAAACTACCATAGGGTCTCTCTTAAATAAGTTAGTCCTGGGAAGAGACAAACTCCCCTTAGCAGGGCTTAGGCTTTTGTCCTTGTTCGTCCCACCTCATCTGGCCTCTTTGTTTCTTGCAGAAATTAATGAGCATAAATTACCTGGGCAGCGTGTACCCCAGCAGGGCAGTAATCACTACCATGAAGGAGCGACGGGTGGGCAGGATCGTGTTTGTGTCCTCTCAGGCAGGACAGCTGGGACTGTTTGGTTTCACGGCCTACTCTTCATCCAAGTTTGCCATAAGAGGATTGGCAGAAGCTCTGCAGATGGAGGTAAAAAATACATTTATTTCTGTATTTCTTCTTCTTAGATCAGCAGGGAGCTCTGTCATTTTTTAGCTCCTTAGCCTACATCACTTTGTAAGCTAAAGGCTTACAGAGGTGATATCTGTAAAAACAAAACAAAACTAACTCAGTTGTAAGATCTGTGTTTTAATACTTCTTATTGTATAAAATTATACTTAGGACAGCGGCAAAATGACTCTGAGGGTGGAGGGATTGTCTACTGTATAAAGTACTTGAAATCCCTTCCTGGTGTTGGTCTGCTTCTGCTTAAGTGAACAGGGATATCATTATAGACAACTTTCTGAAAGCTCTGGATGTGGTTCTGGGGAAAATGCTTGTTTTACAGGTTGGGTAACAGAGTTTGACTCTCCAGAACTCACATACATGTTGGGCCAGTGTAGCAGTCTGCCTGAAATTCTAGTGCTCAGAAGGTGAAGATGGGAGCCCAAAGCCGCGTGGCTAACGAGCTAGACCAGTCCTCTCAGTATGAGTCAAATTTGCGAGGCTTACGTCAAAGAATAAGGTAGAGGATCATTAAGACAAACTCAATATTAGGCTTAGGCCTCTGCACACACATGCTCAGTTAAGCTGTGAAGTTGCAAGAGAGGATCCTGGTGATTCTGTGCAAGGATGCTTTGCAAATAACCATGTTCGTGTGTGCATAGGTCTGTATGTGTGAAATATGTGCACAAACTTCTTCATACCACTTTCTGGAAAGGGGAATTCAGCTTTTAGTGAATTCAGTGAGTTACTTAGAGTCACATAGTCACTTGGTGACAGGAATAACAAGGCCTAGCCCCGTAACTGCAAGCTCCACTGGTCTTTTGCAGCAGAGGATGTATCTGTAATTTGGAATGTGCATGTGATGTGCATCTGGTAGCTGCTTTATCTGGTTTGGGATTTTGGGCTTAGAATCCATTCGGGTGCAGAGTTTGAGAGATAAAAATGTATGCCCATTAAGGCCTTTCCTGAAGTCTGACAGTATGATCCACAAATTAAGGGCAAAGTGTATCTCTGGGAGCCCTGGTTTTCATTGCAGAGGGAACAGTGACCCAGTGGCTGCATCAGAGTCGCTCAGCTTCTTGATGTCAAGAGTGATCTTTCACACTGCCCAAAGCTGACTGGGCTAAGTCGCCTTGACTTCTGAGCATTAAAATTGTTGTTACTTAAATAAACAAACACACATACCATCTAAAAGACTGCTATTTTATTTGGATTAAGTAAATTCAGACTTTTGAATCCAACTTGTTTGTAGCAAAATTTGCCTCAAACCAAGATTTTCTTATCAACTAATAATTGTTTATTGAAATCTAGATAATTTGGTCAGTTTTTTATGAGTTAAACCAACATAGTTGCTTAAATGCTTGATGCTTTGGGTAAACATTTTGGTTTAATTAACTTTTTAAGTTTTTCTAGTTACTATCCTGCTTCCTCCGACAAGGTATAAACTCTGAAAATGTGGGCACAGTGTGTACTTGAATGCTTTGTTGATATTTTGGATTTGATTTTCTTTTTTCTTCTTTGGTCTTTTAAATACAAAATTAATATTTAAAGAATTTTTTTTCAAAAAGTTGATCTCTTCGAAAGTGTATTTCTGAAGTCAGTTATAGCCAGAGATTCAAGAATCAACCATAACAAAACAGGAATCCCCAGCCAGGATTCCTCCTGTTTTCTCACCCAGACCATGCCTGGCCCCTCCCCTCATCTCTTCCCACCATGGTAGACCAGTAAGCTGGAGCTGGGATTCTTTAGTTTGATATAAGCAGCTGAGGTTCCTTCTCCAGCCCCAGTGTTCTTGTTTTAATAGAACAGCTCTTAAGTGGCACTGTTTTTTTATGATAAACTCATCCTTCGCAAGCCATCCATTGTCTTACCTGTGCGAGGCTGGTGCCAAGTAGAAGGGAGAGTAAGAGGACAGGTGAAGAAAGGCAGAGCAGGAGAGTAGAAAACGGCCCTTTCCCAGGGCCAGGGAGAAACAGGTCAGCGAGGCATGAGTCAGTGAGATGAGTGTAACACTCGTCGTAACCCTCGTCGTAACCTAGAACAGGCGAATGTAAGCTAAGCCGTCCCTTTTTGGTTGGGTTATAGTGTTAACAGTTAGAGAGGTGTAAGAATAATTTTGTATGTCCTGGTTTTTGCAAATTATGTGAACAAGAGTATCAGGAGACCAGGAACTGGGTTATGGACAGAGAGTTGTCCGTTTAGTTCATTCCTGTACGGAAGTCTATGTTGGCATACAGTAGTAATTTAGAAAGTGTTTACTGGAAGCATCCACCCAGATGCTAGCAGAATAATTGTGCTTGATGATTGCAAAAACAGGGTTGGCTCCAAAGGTGATGGACTGGTTCCTCTCCACCTTGCTGTTTCCAGTCCCTCCCTGTGAGAGAGCGGTTGCTAACCCAGTCATGACCTTGAGTTTGAGAGACTTTGAAACATGGTTTTGATGATCATAAACGGCACAGCCCCCACTGTGGGGCAGCGCAGTGGGGGAGGCAGTTCAGAGTGGGCCAGAGAAGCCAGCCTGTGTGACTTGCGTAGTTAACACTCAGGCACTTTTTTTTTTAAAGCCATTTTTCTCTGGTCCAATACAGGACCAGACAAGACTACAAGAGACATTTTATCAATTTTCACCATCTCAAAAGCAAGTGTGAGAGAAGTCACTTGATCTTTGTTCCAGCTGGCTCACCTGATTGGCCTGGGAGACAGCAAGCACTCCCTGGCAAGGCCAAGCCATGAACCCTCATGACTTGGATGCCTGGAATGGAACCAGCTTTCATTCTTGTGATTACTTGGATGGGTGCACAGTACCTACCTACTGCTTTGTTCTCTTGACCCATGTTGCTGTCCCGAGCCTTCATAGCTGTGTCACTAAAAGAGTCTGGGAGCTAAGGGGCTGGCGCCCTGGTAGACGGGTGGGGCTGAGAAAACCTGTCGGATTTCTTCTTTAAGATTCTCAACACTAGACTTGTTGCCGTCCCTCCCAAACACCCAGATGTCTTTATGAGGACAGAGACACAAGCCAGCAGTACATAAAAAAGCATGCCAGAGTGGACTTGGTGGTCTGAGCCTTTGGATCGCTGATGTCCAGGCAAGAAAGGAACAGGCGACAGCGACCGGACTGCTGTTGGACAGTTTTGGGAGACTGACCCTTGAAAGAAGGGCCAGTGGGGTTGTTGGGGTGTCTTCATCAGTAGAGGAGTTGACTGGGCAGAGAAAGTGGGAGGCAGACAGTGTTGGAAGAACTAGAGGTTATAATAGGCCTAGTACCTATAAAGAAAGCCAGGGAGAACTGGGCATAGTGGTGCACACTTGTATCCCAGGTCTTCGGGAGACCATGGCAGACAGATCACCAGGTCAGACTAGCCTGGGCTAGAGAGATCTTACTGATAAAAAGGGCAGAGGGAAGAGCTTCTCTGTATAAATAGTGGTAGGGGCTGTTTACAGGGGAGTTGCTTGGCTGGTCATACTTTGGTGGTCTACCCAGGATGAAGATGCTTTCTTCCTGATGCTATGTGGGTGGTTATGCAGGGACTTCTACAGGGATGGATAGAGTTTCCAAATCTGGATTCAGACACAGTAATGTGCATCCGGGTAGGCACTGAGAGACGGTGTTTTGCAATTGAAATGAACATTGCTGTATTATAGCAGCCTGAAAGGCATAGACCTGCCTTCTGCCTTGAGCTGTGCAGTTCGTGGGCAGAGTCTGTGATGAAGGAGCATACTGTCATTCCACAGCATATGCAGTTCTCCCTGGGCAGCTCTGAGCCTCTGCTTGGTCAGCCGCAGGAAGAACTCTACTAGGAGGGGGCTTGACACACTTTAGAGCCAGCCACTTTCTGACATAGGTCAGGGGTACTCTTGCTACTGTTTCTAAGTCATCTTCATGGAGAGGGGTCCCCAGGACATTTGGTGCCTGTTTACTGATAGCCACTTCATGAACCTGACAAGCAACACCTTCTAAGGCAGTGCTCTCAGCCTTCCTAGTGCTGTGACCCATTAATACACCTTGTGTTGTGGTGACCCCCAACCATAAGGTGGTTAGTTGCTATTTCATAACTGTAATGTTGCTACTATTATGAATCAGTGTAAATATCTGATATATAACACCCCCCCCCAAAAGGGCTGTGGCCCACAGGTTGGAAGCACTGTTCTAAGAATCAAGATAGCTGAGACAAGTTACAGGATGACTACAAAGTGCTCTGTTCACTGAGAGTGCGTACCTTGTTTGTGTGACCAGGTGAAGCCGTACAATGTGTACGTCACTGTGGCCTACCCACCAGACACCGACACGCCGGGGCTGGCTGAGGAAAACAAAACGAAGGTCAGTATTCCTACATAATGCCCTCTGTGAGGAGTGTGTGATGGCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCTGTGTGAAGCGTTTTGTGTGTGTAATATGTGTTGTGTGTGTGAAATACATGTGTGTGATATGCATGTTGCGTGTGAAATGTGTGTATGATCTTCTGTGTGTGCTGTGGGGTGTGATGCATATATTTACACAGATTCATAATAGTAGCAACATTACAGTTATGAAATAACAACTAACAACCTTATGGGTGGGGGTCACCTCAACACGATGTGTATTGTCTGTGTTATGTATTGTATGTGTGTGATGGATGATGTGTTTGATACAGTGTTAAGTGTTCTGAGTGAGGTGTGTATGTGATGTGTGTGTGTGTGCACGTGTGCATGGTGGTGTGTATATAGTTTGTATTTGTGACTGGAGGAAGTTGTGCATGTTTGGGTGTGTGTGTGTAGTGTGATGTGTATATGTGATATATGGGGGTGTTATACATATTTGGGTTTGTGTGGTATGTATGTACATGTTTGGGTGTATATGTGCGTGTGCATGTGTGTGTGTGTGTTTGGGAGTGTGCAGGTGTGTATGGAGACCAGAGAACACCCTTGGGTATTCTTTTTCAGGTGGTGTCCTTGGTCTTGAGACAGGGTCTCCTACTGTCCTGGAACTATCAAGTAGGCCCGGGACTTCTCTGGTCTCTACCTCCTCCTGGCTGGCTTTGCATGTGCGGGTGCTCAGAGGCCAGACAGGCACTTTATCTCCCTAGCTCTGTTCTGAATCTTCAGCGTAATTTTTATGAATGTATCCTACTTTAGGTCCTGGCTGTTTATCAGTTAGTGGGTCTGTTAGGTGCAGGGTGCTGAGCCAAGACTTGACCTTCCAGGCAGAGCTTCCTCCTCCCTTTTTCTGCTCTCCAGTCCCCTTTTCTTAATGTTGAACTTACTTGTTTCCAACTTTTAGCTCAGTATTTTCTCATAGGACGCAGTTGGCTGCCTAATGCTACCTGTGGCCTTATCACTCCCACTTCTGACCCCTGACCCCTAGAGGGAGCCATTTCACCTATGTGTCTAAACCAATCCATACATACATACCTACATACATACACAGTGAATGCACCTACATGCATGCATAACATGCATACATATATGCACATACATTCATATGCATCTACGTACAAACTCGTGTTTTAACTAGGGAAGCTAAAATTTGAGCCTCAGGTCTACTTTGTTCTGCCTGTGTGACCTCTGTTGGAGTCAGATTCTGTGTTTATGAGTGTTGATAAAGTTGAACCTCTATAATGGCATTTCCTTTCCTGTGTGTCTTTGTTTAACTGAGAGCATTTGTAGGTCATTCACTGGGGAGAACTGGACGTCTTTTGAGCATCTGAACCACTGACCTTTCTGTTACTTTCATTCTTCTTCCTCCAAGCCCCTTGTCATGGGGCTCCACCTTCTGCCAGGACACAGGCCCTGGGGGTGACATCCTCTGCACTCCCCTGTGCTGCGCTTCCCTTCTCTGTCCCTTGCTCGGGTCTGTGCCTTCCACTGCTGTCATTTCTCTGCTCACCTTGGTGGCCCTTCAGTCATTCCAGAGAAAGGCACGTGAGAGGCACCATTTGTTTAGAGTCTGGTTCACAAGAAGGCATCTTCCTTTTCCTATTTTTCGTTGCTGTGTGTGGTAGGGTGTTTTACTGGGTGACAGTTGAAAATGACGGTCCTCACGGCTTTGCGGGCATTTCTTACTGAGTTCTAGCTTCTAGGGTTTCCTGGGGACCCCACTGACCTGAGATGCCTGAGAAAAGCAACTCGTGGCTTGTGGTTCAGAGACACCCGTCCATCAGGACAGGGAGAACTGGCCCGGCAGATCAGTGCTCCTTACAGGAAGGAGAAAAAGGGGGGACAGCAGAGAGCCAGCTGAGCCATAGCCTCAGCAACACATTCCTCCAGCTGGGCTTCAGCCCCTACCTTTCCCCACCTTCCACTAATGCTCAGGGGCCAAGCAAGCATCCGTGACTGAGCAGCTTCCTCATACACATGGGAGGTGTGTACTCCTGGTGGGGTTTAGTTGTAGACACTCTTTTCCTTTTTATCTTTTAGAATGCCGTTTGGTGTGAAGTGTTTTATATGCTAGATACTCAGGACCGCCCCTTTGTTCTCTCATGCACTCAGGTCTGGAACATTGAGGTCATTGTTTCCCATCCAGAACACTTGGAAGCATTCTTTGTGCAGTTGTCGCTCAGGAGCCCCACTTTCCGGCTGACTTCACCACCTCATCTCTTACTCACTATTGGTTTCTTCTTCAACTTTATTTAATTTAACTTCAATTTTTATTTCTACTGATTTTTTTAAGCTTAGATCTATCTGTCATGCATTTGTCTTTAGTTACTGTTCTGTTGTTGTGAAGAGAAACCAAGACCAATATAACATAAAAGAGAGCATCTACTTGGCTCTGTCTTACAGTTTCATAGGGCTAACCATTATCATCATGGCAGGGATCATGGTGGCTCTCAGACAGATGTGGTGCTGAAGAAGGAAATCAGAGCTAAATCCTGATCCACAGGCCACAGGCAGGTAGACAGACAGACAGACACACACACACACTGCACCTGGTGTGGACTTTTGAAGCCTCCACCCCGTTCCCACTGAGTTTTCTTCTATTTCTAAGGAGCTTCAGTCAGAATGTTGCTTGGTTGTATTTTTGTTCTGTTTCTTTTCTTGGTTTTGAGTCTAGGTGTTCTCGACTCTGCTCATGTTGGTGATTGCATTCAGCAAGGCAGTGGAGCACAGGTTGTAGAGCCATGTAAAGCCCTTCCGCCACCTTCTGCTTTACATATGGAGGATGGGGTGGCAGTGGCGCCTTCGTTTCCTTAGCGTCTCGTGTGTGGACAGATGGCATGGGACTGGTCATTTCCGCCCCAGTGGCATCTATCTCCCTTGCATGTGTGCAGGTCATACAGAATGACTGGGTAGTCCTGAGCTGAGAGTAGGCTCTATTCATCTGGTTCCCCATCTTTCCCTCTGCCATGACACAAACAAACAAAACAGATAAACAGGTAAAGTGGGGCTGAAGGAAACCCACGAAAGCTTACCACCTCACACTGAAGGTAACCTAGTTTTAGACTTAATTATTTTATGTGGTTTTTCCTCTTAAAGTGTATGTGGATCTCTGTAGCATAAATTTGGGGTGTTTATGTAGTCTATATTCGGTTTTTGTTTGCCAAAAAAAAATGGGTTATTTATGTAGAAACAACCTCTTCATTTTCTTTTGAGTTCAGTCAATTTTATAATTTCTTTTTGCTTTAAAAACATAACTTGGAACCAAACCTCCTGCTTCAAACCTGCTAAGCAAGCATTAATATTTGCTGCATACTCTTTAAGTCTGAAGCCAGTGAAGTAGTGACTTCCCTGAGATTTGGTTGTTTTGTTTTTGTTTAGCCTACAGTAAAATTTTAGACAGATTTCTAGTGACTGGAACCTGCATTGATCTGTGGGCCCAATAGGGGGCAGCAGACACTCTTCTAACTCAGTGCATCTTGCCTGTCCTTATCCACCTGGTGTGGAGGGAGAGCAAATCGGTGAGATGTGTGTCCTCTCAGATTCTAAAAAAAAGAAAACCTGACTTTTGTGAAACATGAGCTATGTTTCTATAATCACAGTATTCAGGAGGTCGCAAGCCTGCTTGGGCTACATAGTCAGACCCTGACTCACAAAACCAGACATGGAGGAAAAAGTGTATTCTAATCTTTCCCCTCGAGCCTACATAGTCACATTTAGTCTCCCGTGGCTTAAGGCTTCAGTTCGAAACTTTTCTTTTGAAGAATGTTTGGATGTGTGTGTAAAATGCCACTCAGAAAAGCCAATGGGAACAGACAAAAACGTTGCCGCTCACAAGTCAATTAGGACAGAAAGTGTGAATACAGAAGTAGCTAGAACGTGAATTAATGCAGAAATGAAGGAGAGGAGAGAGGGAGAGAAGGAGGGGGGAGGAGAGAGAGAAACAGACACAAGAAGCCCGGAATGAGGAAAGGTGTTCTGAGCTAAGTGCGAGCCGGACAGACCTTTATCTGTCTCTTGAGGAAGAGAAGCCTAGGATTTGGGAATTGGGCCCTGAGTCCTGTAACTACCTCTCAGCCAAACTAGGCAGGAGGCAGTGTTGCTACTCAAATGGCTAGTGTCTTCGCCTCCTCTGCTCGTCCTTCAGCAAATAGATACAGTTCTTCAATGGGGGCTAGGCCCAGACTGTCCTCAATCTGTCCCCAGCATCATTCATCTGCTCAATGGGGACTCTATTCAGAATGGAGGCACGGTCCTACGATGGATCACGTTTGCTCAGTCACAGGGACGAGCCTCTATGCACATACTGTCTGGCAGTTGTCTGTCCAGTAAGAGAAGGGGCCCTTCCTCACTGTGACTGACAGACTGATCTACTAGCTCCGGTTCTGGAAGGCCTCACTAGAGCCGTGCTTGCACCACCCAGAACAGCAAGTACCTCCTTAGCCCTGCCAATGGAGATAAAATCCCACACGCAGAGACTGACTTAGAATCTAGCTTGATCTTTGTCTTGAACAAACGTATTTGTTCGAAGGTAGAAAAATGATAATTATTTGTGATCCATCTATAAGATGTTTATTTTAATTCAGTGGAATTATTTTAATTTGTATATTTCTCCCACTTGCAGCCCCTGGAGACCCGGCTTATCTCAGAGACCACAGCTATTTGCAAACCAGAGCAGGTGGCCAAACAAATTGTCAAAGATGCCATAGTAAGTAAACGCCCTTGTGTGGCTCTCTGTACTCCGTGTATTTATACTGTGTTCCTGAAAGGCACATAAGGACTGACTTCAGAGCAGAGCGTTCGGCTTTGCGTGGGGTTTGTCTGACGTCAGCCTCCACAACCTCCTCCCACTTCCTGTGGATTCAGCATTAACCAGAGGGATAGCGTCACGGTATTGTAAGAGAGCTGAAGCTCTCGGAACGCAAATGACCACTACGTGAGGAGAGGCAACTTCTTTTAATTTTTATTTGTAATTTTACTTATTGGGTGGGTGTGAATGTTGCCTTCTTACAAGAAAATTTCTCTCATCTACCACGAGAGTCCAGGGCATTGAACTCGGGTCATTAGGCTTGGTGTCTGTGCTTACCCACTGAGCCTGGCCTTGTCCTTTACCAGGGTTTCAGACCATCTAAGGTATTTGATTGCCAGGCTCAGGATGGGTTTTTCTTTCCCTTCCTGTTTCCTGTTACTACTTTTCTTTCTCATGGTTCACAACAAAGCTGCTGGCCCCACCGTTCCTCTCGATCTACCTCCTCACACACTTAATTTGTGGGGAACTGGCTTTTGAAACCATATCAAGCATTATATAGAACACTGCATACCACAGTTCTTTTGAATACATTCTGATTAACTCACTTGTAGAACAAGGTTCAATCTGAGGGATGTCCGTAAACTTAGTAACCTACGTGACTTTGGAAAGTTTGCACCCAGATAACATGGTGCAGCTTCTAAGTAGCAAAAGGGGTGTTGTGCCAAGGTTAGCAGGACACAGTAACAGCAGCCTCACCAACAGACCCAAAGACCTGGTGAGACAGCTCAGTGGGTAAAGGGACTTGCCACCAATCCTAATAACCCGAGTTCTTCAGACTCCAGTAGTGGAAGGAGAGACCTGACGCCCTCATTTGTCCTCTGGCCTCTACATACATGTTGTGTGATACATACATATACACAAGTATGTTGCGCGCGCTCAACTGGCCAGGAAGAACGACGCTGCTACAGGATCCTTCTGCACACGTTTATTCAGTCCTGTTTCTTCTTTCTCTATATTTCCCTTGTTTATATCTCCCTTGTTTATATCTCTCCCTTGTTTTTATCTCCCTTGTTTTTATATCTCCCCCGAACCCTGGGCCTCTCACTCTTTTATACTCTCAGTTCCCATCCACGCACAGCAGGCCACGCCACCTCACCAGGCACGCAGCTTCAGCTAATCAGGGCAGCAGGGGCAAATCTCCACCAAATTCGATTCACCTGTATCCTGGTACACCTGCGCAGCACTCAAGATGTTTGTGGCTTATATGAGGAAGTCAGGTGCAAGTCATATGACTTAGCTGCAGTCTCTGGCGCCTTTGGGACTGCCGCCACACCCGCTCCCCACAATTCCCCCTTTTTTCTTTTTTGGCAGAGAGAATGTCTGTAGATAGCCCCCCGCAGCCATGTCCCTTACCCGTCCTTGGGTGACAAACAGCATTGGTTTGATCCCTGTCTTAGGTTGGTGACATGCCCAGGGACTCTTATCACTGACTACCTCTCTATCATGCCAAGCCACTCCTGGGGAGATTGTGTTTTGCTTGCAGCAGGTGCATCAAAAGGCCAGGATGTTAATTAACCTATGGCCAGATCTTAATTGCTGCAAGCAAGCCTCATGGGTGAAGGTAGAGGTCTGATCCCCAATGTGCAAGCATAGGGGCCCTACACAAAACCATCCCTTAGGCTCATCACCCAGAGAGGTCTTGGCCAGCTCCCGTGTCGTTTTTCCTGGGGGAAGGGAACTAGGACACTGAACCTTCATGGATCAGACATACCTTCCACAGGATGCCAACAGCAAGCTATCCTCTGTGCAGTGCTTAGCCTCGCACCCCACGGCATAACGCAGCATAATTTCTTTTAGAGTGGCAAACCAAATCTGAGGAGATTGTCCCGCCTCCACTGCAGCAAAAGCCTACGCTACCATGGCGAAAGTGCGGGCCGCACACTCTGCACCTAACACATGTGCCAAACACAAAACACACACACACTATAACAAGCATACATCCCAGGGCTCTCATCCCCGCTCATCTTCCCTGAAGCAAGGGATAGATAGCCAGAGGGGCTATCTCTTTAAGGGAAATTCAGGGATCAAAAAGCGTGGAAAATTTTGAATGTCATGTCGAGCTGGTATCGGCTTCTGGAATACCGAAAGGATCTCCCATCTCGGCTCCATCCTTTGTGCTTGTGGGATCATCCACCACATCCACAGGGGCAACTGGATCAGGAGCCTCATTCTTGCAGCGTCTCACCAATCTCTCCAGCACCCAAAGAGGTTCTGTCTGGTCCTGTGGAAACACACAGACCCTCTCGCCCATGTCAACACCTGATCCTGTCGATCCTCTCCAAATCTCCGGACAGAAGGTCCACCTACAGGTGGCTGCTGAGGAGGCATAGGGAGGCGGCACAAAAGCTAATTCGCCTTCCTCCTCCACCTCGGCTCTTTTATTTCGTCCTTCCTGACCACCTGATAACACTGTGTCTCCTTTCTTTTTCCTTTTTCTTTTTAAGCCCTTCTCCTCTTCCGACATAATTTCTTGTTGCTCTTTAAGGATTTTCTGACCTGTCTTGACTGCCTCTACACACAGTTTCAAACAGTAACAGAGTCCATATATCAGAACAAGCAAGACCAAAACTATCAGACCTACCCACAAAGGGTCAATGGGAGAAAAAAGCATAACTACTCAGCGAGGATCTATTGATCACTACACTGAGGTTATCATAGTTCCTTAACTTGTCCCCAAACCGGGAACCTTAACTTGTCCCAAAGCCGTGAACCTTTAGTTACCTTGTACCTGCTTCCTGGCAACGTTATATTCGCCTCTATTTTATCGGAGGTCCTTCCCAAACTCCTGGGTTACTTTGTGCCTACTTCCTGGCAACTTTATGCTCACCTCTATTTTATCCGAGGTCCTTCCCAAACTCCTGGGTTACTTTGTGCCTACTTCCTGGCAACTTTATGCTCACTTCTATTTTATCCGAGGTCCTTCCCAAACTCCTGGGGTCGCAAGTTTCACTCACCGTGAACTTACCCTGCGGGCAACCACTGACTGCTGAAAGTTCTGAACTCGGTGGGGGAGTCGGTTCCCCATACGGGCCACCAATTGTCGCGCCCACTCTCAACCAGCAAGAACGACACGACCACCAGTCCTTCTAACAGCAGTTTATTCCGTCCTCATCTTTCTTCTTTCTCTTCATCAGTACCGTTCCCCAGCTGAAGAGTTCTGAATCCACGCCGGATCCTTCTCAACAGTCTGTTTTACGGGAACTTTTATTAACCACTCCTTCCCCGTGATGCAGTTCTGAATCCTCCCTGTAGCAGGGGGTCTTCACTCATGCCTGAAGATGTTTCTTGTCCCGGGTTTCGGCACCAACTTGTTGCGCGCGCTCAACTGGCCAGGAAGAACGACGCTGCTACAGGATCCTTCTGTACACGTTTATTCAGTCCTGTTTCTTCTTTCTCTATATTTCCCTTGTTTATATCTCCCTTGTTTATATCTCTCCCTTGTTTATATCTCTCCCTTGTTTTTATATCTCCCTTGTTTATATCTCCCTTGTTTTTATATCTCCCCCGAACCCTGGGCCTCTCACTCTTTTATACTCTCAGTTCCCATCCACGCACAGCAGGCCACGCCACCTCACCAGGCACGCAGCTTCAGCTAATCAGGGCAGCAGGGGCAAATCTCCACCAAATTGGATTCACCTGTATCCTGGTACACCTGCGCAGCACTCAAGATGTTTGTGGCTTATATGAGGAAGTCAGGTGCAAGTCATATGACTTAGCTGCAGTCTCTGGCGCCTTTGGGACTGCCGCCACACCCGCTCCCCACACAAGTAAATAAATATACATTTAAAAAAAAAGAACAGGTCTGCAGAGGTGGCTTGGTAAGTTCTACAAGCACAGGACCCCACTTCAGAAGCCACATGAGCCTCCACTCCCACCCCTTTCTGGCCTTCTTGGACACGGTACCATTACATACATGGTGCACATGCATACACGCAGGCACCCACACATACATATGTTTTAATTTTAAATCTTAAAACAACAACAAAAGGACTGAGTTCCTAGCAGTAACATAAAAGCCAGTAAGCCAGTATGGTTGTTCCTGTCTGTAACCCAAGTCCTGTGTGGACAGACCGGCAGATCCCCAGATCTTGTGAGCCAGCCAACCCATCCAGTCTGTGAGCCTAGCCAGGGTCATTTTGAGACCCGTTCACAAAAGATAAGGTGTAGAGTGATTGAGGTAGATACCCAACATTGACCTGTGATTCCCCACACATGTGCCCACAGACATGTAGTTTGCCCTGGTTGCCTTTAGAGACTTGGAGCAGTGGCACAGAGGCATGAAAGGCTAATTTGCTTTTCCCTCAAGTCAGAACAAGCACCCTCAAGGTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCATTGTCTTAAGATGCTGGTACTTGCCATGCGTGTGCATGGTGTTGGGTTCCATCACCAGCAGAAGAAGATGGGGAAGAGATTTAGCTAGGAGATAAAGTCATTTGAAATCAAAGAAATTGAGACTGGGGAATTGCCACAGTGATTAAAAGCACTTGTTCTTGTAAAAGGCTCTAGATTCATTTCCCACCACCACATGGAGGCTCAGCAGTTCCTCAGGTGTCATGTTGTACCCAGACATGCATGCCATCAACACACACTCACACACACACACACACACACACAGAGAGAGAGAGAGAGAGAATAAAACTTAACTATATTATTAACTCCATTTTTAAATAGCTTTATTTGTTCTTTTAATGTATCTTTGTGCCTGAGTGTATGTATCTATGTGCAATGCCTGCAGAGGCCAGGAGAACACCACATCCCTTGGACTGGATGTATAGGCATTGTCCCCTCTCTTTATGGTTTCTTTTTAAGTGTGTGTGTGTGTGTGTAACACTCAGAAGACAGATTTGAGGAGTCATTATTTCCTTCACTGGGGTTCTGGGATCAGACTCAAGTGGCAAGAGCTCTCGTCCGCGGAGTCCTGCCTTTTCTCAGTTTCTCTTCATATGGGGCTCCAGTAGCTTCAGCCTCAATAGCAGCTGAGGGTGACCTTGAACTACTGACTTCCCACTTCTCAGTGCTGATATAACTACTATGTGTGGCTCAAACATAGCTATTTTCAAACAGAAATTCATCAGGAGGAGTGGCATGGTATTTTCACGAGCCTTTACAAAGTCCACACTAGTGGATGCCAGCTGCTTTCTCGTGTCTGCTTCTGTGGCCAATCTGTTAAATACATTCATTTTGAAACATTTGAAGAAAATGTCACTTTAATCAGATACATAGTTGGGAGGGGATAAAGTTTTCACGGGATTTTCAGATAATTATGAACATAATGTTCTTTCTGTTTTTATTTTTATATTAACCCCCATCTTGACAATTAGGCGTTTCTTAAAGGTTGGTTGCTGTATGAAATTAGAAACCACACACCAGTGAGCTTTTTGTTCTCGGTGACACTAAAATGCATGTCTCGTTTCTATATTGAATGGATCTTTCACTCATTCATCATTTGAAAACATGCATTAATCATTTGGAAAATATGGAATCTGTGAGTTATCAAAAGTCACATTCATCAGAGATCAGGGAAATATCAGGAAGCCAACTGTCTCCTACTGATGGATAAAGTTTTCATAAGTCTTAACTTTTCCCCATGCACATATATAATCTGTGGTCTTCTTCCTAGCCACAAGTTCAGTTCATTTGTCTGCCCTATCTGTGCCTCAAGCCCAAATTGGAATGTTCTAGCCTCCTGGTAAATAGTTGTTAACAGGAAAATAGTTTTGTCAGGAAGCTCAGCTCTGAGGTGTTCCCAGTTAAGCTAAATCACTCGTGGTGAATTTCTTATTTGTCACCTGAGAACAGGAGTCCTCTTCCCAGTGTCCTCCAGGAGATGGGCCACAACCAGCCAGATGTCAGATGCTGCTGGTTCCTGGGTATGATGCTATGTGTACTCTCCTGTGTATATACCTGTGAAATAGCCTAGCTGGGGATGGAGCTCATTGGTAGAGTAATAGTCTAGTATGTATGAAGCCCTGGTTCCTCCCTAGTACCATATAAACTGAGAACACATGCCTATAATCCCAGCACTTGAGGAGTAGATAAGAGAGGATTGAAATTCAGGGTCATCCTCAGTTACAAAGTGAGCTCAAGCGCAGCCTGAAATCCTGCCTCAAAAACAAACCCCAAACCTGTTTAATGAATGGATTAGGCCCCTGGTTCTATTGAGGAGCAAAGAAGTGATACATATCCCACGTGGGGCAGAGCTGGCCAGCCCAAGATGCTGGGGTATCATGCAGACAGCATGCAGTTGACCCCTTCTGAACCACTTCTTAAATACAAAGCGTCTTTTGGGCTCTTAAAGACTTTTTTAGAGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTTCATTGCTGTGGTGGTGGTGGCACTGGCTGCATTAGGGCCACACTCTCAGAAACTCTCCTTTGTGCTGTGGTGCTTTTGTCCATATGCACAAAGGTCAGTGGGAAAGCAGCTAACGTCTCAGTGTTATTTGACGGTTTCATTGTCCCTAGAGACCCTGAAAGGGTCAGGAACCCACAGGGATCTGTGGACTTGTACTTTCAGAGCTGGACATACTTTACGTCTCTGTGTCCCTTTTTAGTTCTGGTATATTTTGAGTCGCTGTGCTGTCCCTTATAAAGTGAAGGGACATACTTCCCTGTTCCTCAGTGCTGAACTAATTCCTACAAACTTACTCCATACCACTCTTTTCTGCTTGCTTCTTTCCTAGCAAGGAAATTTTAACAGTTCTATTGGCTCAGATGGGTACATGCTGTCCTCCCTGACCTGTGGGATGGCCCCGGTGACTTCCATCACTGAAGGACTCCAGCAGGTAAGCCCTTTCTTAGCCAGCAACCAGGTAGACATACAGACAGGTAGACTAACAAAACAAGAATCACTGTTACCAACTTCTGTGAGAAAAAGATGAAGACTAGAGTGCAGTAGTTTTAAATTAAAGTTTGTTTCTCTCTCTGCCAACAGTAAGTAGGCAAGCAGGTTAAGGATATGTCCTGGGCAGAAGTGAGGAACCAGGCTGCAAGTGGAGGAGGGGCCGTCGCTGTTGTTGGGTGCTCACCCATCTTTTCAGCAAAGAATCCTTGCTCTAAAGTGTTCAAAAAGGAACACTTGGCCAAGAATTGTGGGGGGCAGCATTGTCCACAACCAGTGAAGTATTAGCTTAGAAACCATTTTCTAGCTCATCAAACCTTCCAGTAGCTAAGCTGAAGGAGACTCAGAGAGCAGACCAGACACACCTTGCCTGTAAGAGCTTCATCCAGATTGCCAGCACTGTCATAAAAAGCCAGTGTGGTCTCTCCTATCTGTAACCCAAGCCCTGTGTGGCAGATCCCCAGAGTTTGTGAGCCAGCAACCCATCCAGTCTGTGAGCCTAACAAAGATAGGTGCATGAGTTCTTTCCCCCATGTTTGTCTGTACACCACATGTGTGTAGTGCCCATAAAGGGCAGAAGAAAACATTGGATTCCTGGAACTGGTGTTACAGAGAATAAGCTGCCAACTAGGTGCTAGGAATCGAATTCAAGCCCTCTGGAAGAATGACGTAAGCTCTTGACCTCTGAACCATCTCTCAGGCCTGAAAGTTTACTCCTGTTGATAAGGTTCTGTGTTCCCCAGATGGTTAGGTGTAAGAGGGTTCACTAACCCTTAAGGAGTCTACTACCATGGAGTGCTAAGACTGGTGGGCAGTGCTAATGGCAGCCATGTCATTAGAGCTGTAATGGAAGGAACCTTTAGGGACAAAGCCAAGCATCATGGCTGAGAAAGCCCTGGTCTGTGTGAGGTGCATTCAGATAACTCCTAGTTCTTTCTTGGGCCTTTTCCTAGCCTGTCTCATTCTGAAATGTCTCCCCATCATGATTTGCTTGACCTTGTTACAGGTAAGATCTTTGGGGACAGGGCCTAAGTCACTCTTACTTGTCACTGGACCCCAGCAGCCAGTACCTACATAACACAGGAGTTTTAGATTAGTGCACAGAGTCTGCACCTGTCCACCTGTCTTGCCCGTTCACACAGTGATGCCAAATCTAAAACTCAGTCTAGGCTGGGTGCTAGGCTGGATGCTTTTACCCAAGCCAGCATCGGGCTGTGATCCCCGACCACCCTGCTTCAGCTTCTTTCAGGCTCTGGTCCCACTCATCACCATGCTCTTCAGATCTCTCTCTCCCGAATTCTGCATCTCTGCTGATGATCCCAGAGTTGAGACCAACATCACAGTCCTTTACCAGATCCACATATGTTGTGAGCTAGAACATGAAAAGTGACGTTGTGGTCCATCTGATAGAAGCCACTCTCCTTACACTGACTCTCCTCTGCCACCCTCCCTAGCACTGAGATATGGGTATGAGCCAAACTCCAAGAGTATGTACATTTAAATAAAGTTGTTGCAAAATCAGATGTTGCAAAAGAAAGAAATCCAAATTTGAGACATTTATTGGGACATTCAGAGGTCTACCTCAGCAGGCTGCTTTCTCGACAGGAAAAGATGGCAGTCACTCCCATAGAATAGAGCATAACCCCTTCCCAATCCCTGTGACCTAATCCCCCTATGCCAGCCACTGGCACAGATGCTGAGAGACTTTCTTTGCTGTGTTTGTGAAATACAACTAACTCTACCTTACATAAATCCATCACTGGCTCCTTGGGGCTCAGCATGAAACTTGAAATCCAGCGCACAGCACCAGCCACAGCCTGCTGCCACTTCTTTTTCCCTCTCCCTCGGCTCTCCTCATCTCCTCATGTATCTGGAAATGTGTGTCTTTCCATGATGCCATTTGGAGTTGCTTTAATGAGAGACTGTCACTGGGAAGGGCACATGGCTATGGATAATTGCTGCCTTGCCTCCTAGACTGGTTGGTCGCTTTCTTCTTTGATTATCTTTCCACTACAAGCCAATCGTATGCCCACCCGTAGTCGCAGCTCCGTAGAAGGCTGAGGCCAGAGGATCACTGGTGACTAGGAGCCAAGACCAGTCTGAGCAACATAGTGAGAATTTGCCTCAATAAATAAACAGATCAGTTCAGGTAGGCGAGGAATGTATATTTCTCACGTCACGATCCTGAGCACCCAGCAAAAGGGCTTAATACTCAGAACAAAAATTGTAGCCAAGGACACCTTGATTGTAGCATAAGTATCTGGAATGCGGAATTGTACCGTGCCTAGGAGTTATAACCCCGTCTTCTAAGAATGCCTAGTTTGTTCTTTTTATGGTTGGAATTTGTTAATTCAGACAAATATTGTTGTCTGTGTGGCCGTGCTATCCACTGTACAAAGCAGACGTATTCTGTTCTTGAGAATTACTGGCATTTACAAAGTTTTCATTATACCTGTGCTTGGAGCAGATCAGATGTGTCCTGGAAACTGTTTAGAAGAGACTTAACTACTATAAAATGGGCTGTTGTCCTGTCCTGTTGGATGAGCTAACAGGTCTCCCTTTCTCTTGCAGGTGGTCACCATGGGCCTTTTCCGAACAATTGCCTTGTTTTACCTTGGAAGTTTCGATAATATAGTTCGCCGCTGCATGGTGCAGAAAGCAAAACCTGAAGTTGTAGACAAAACTGCCTAAACCTTGCCCCTTGGATGAAAGACTGAATCCAGTGATTTGAACAGTGTGCTGCTAATGGAACACAAGTTTTGGCCTCCAGACTTTTGTATCTTGTTTTTGAATGTGTGAGATTGGACCCCGTGCTCTTCAGAAATCTGGCTGTAAGCAGAGGGACATGAGGCCATCTCTACAACTGTTAAACACTATGCAAATATGGGCCAGGACACCTTTGATTTTCTGGGCTGTAGGGGTGATAGTGTGAGAACTAATAACAGGAAAGCAGGGTAAAGAATAGCATTCCAGAACAGTAAATTCAGCTTTTCGGTCATTCTCCCATCCTACCCATAGAGATCAAGAAATGTCCTCTGTGGCGTTTCTGAGGTTTTGTTTTGTTTGTTTTTTGTTTTTGTTTTGTTTTGCTTTTTTTTTTTTTTTTTGATTTTGGGTTTTAACTTTTTATGAAAGATGGTCCGGATTTTTATTAGTCTTTTTTTCTTTTTTGTAATTTTTTTAGTGTATGTTATTCAAGGTGTGTCTTCCGAGTAGCCCGTGAGTCTGACTCTCAGCATGCCTTGCTGCGCCTGGGACTCGCTTCTGCTAGTGAAGCTGGTTTCTCTCTCTTTGATCCCATAAAATTCGAGGGGGATGAGAGAGCAGCACAGAGGGCAAGGGGTGAGTCCTTTGTGACGGCAAGCGGGGCTTTCTTGTCTTCTTAGACTGATGCTTACAACGTTTTCATTTTTATTCAAGGGGAAAGGCAGCCTCTTTACGTGTTTCGTGAAGAGAAATAAAATCTCCTAGCAGCTTAAGTTACAGTTTCTTCAGGAGCCATGATGACCTGAAGTTCACATTCCATTTCAGCTCAGTTCCTAGTGCTTATCGCTCTTCCTAGTTTTGCTTATGCTACTGTAATATTTTTGTAGAAGAAAGGAAGGAAGAAAAAAAAGATGGAGATCAGTGCAAATGTTTTTGACTTTTTTAATTAATCCATGAATTAATTAAAATAAAAAAATGAAAAGCATGACCTTCTTACTCTCAGAGCATACAATGGAGCTTCAGGGAAGGCAGCTGGTTGTGTACTTCTACTATTAAAAGAGGGTCAGGTTTGGAGGTTGGGTGTTGAGCGGCTCTGTCTCGCGCACTGGCACCCAGCAGTATCTTCAGCATGGTAAGGAGCCCTCTGATGGCAGCCTGTGCGCGTGCACATGCGCAAGACTGCGGTTCCATGGGCGAGCCTGCAACAAGTGCCTCAGATGAGTCCTGCCTGTATCCCACTCATCCTGTTTATTGTTCCCCAGGCTCTAGGACAGTGTTCTATGTCCTGATATTTTACCCTGTTCTCCTTGTATACAAAATACAGCATTTCAGTTCACTCCACCAGGAGAATACTACTTTGAAAGAAAAAACTTTATTGTTAAAAAACAGAAAACACCCGGGCATGGTGACGCACGCCTTTAATCCCAGCACTCAGGAGGCAGAGGCAGGCCGACTTTTGAGTTCGAGGCCAGCCTGGTCTTCAAAGTGAGTTCCAGGACAGCCAGGGCTACACAGAGAAACCCTGTATAGGAAAAAAACCAAAACCMOUSE mRNA SEQUENCE:mR22-022.1 (Seq ID No: 2)TCGCTCGCAAACCCAAACACTCCCGGCTGCTGGTGCATGTGATCTCCCAGTAGTCGCTCGGCAGAGATGTTGCTGTTGGCCGCTGCCGGCCTCGTGGCCTTCGTGCTGCTCCTCTACATGGTGTCGCCGCTCATCAGTCCCAAGCCCCTCGCGCTGCCCGGCGCGCACGTAGTGGACAAGCTACTGCAGGCGAAGAAAGACATTGAAAAGCACTCTATTAATGACAAACAGGTGGTGCTGTGTATCTCAGTTGATGTGTCTCAAGACTATAACCAAGTGGAGAATGTCATAAAGCAGGCACAAGAGAAGCTGGGTCCTGTGGACATGCTGGTCAACTGTGCAGGCACCTCTATGTCAGGAAAGTTTGAAGAGCTTGAAGTTAGTAGTTTTGAGAAATTAATGAGCATAAATTACCTGGGCAGCGTGTACCCCAGCAGGGCAGTAATCACTACCATGAAGGAGCGACGGGTGGGCAGGATCGTGTTTGTGTCCTCTCAGGCAGGACAGCTGGGACTGTTTGGTTTCACGGCCTACTCTTCATCCAAGTTTGCCATAAGAGGATTGGCAGAAGCTCTGCAGATGGAGGTGAAGCCGTACAATGTGTACGTCACTGTGGCCTACCCACCAGACACCGACACGCCGGGGCTGGCTGAGGAAAACAAAACGAAGCCCCTGGAGACCCGGCTTATCTCAGAGACCACAGCTATTTGCAAACCAGAGCAGGTGGCCAAACAAATTGTCAAAGATGCCATACAAGGAAATTTTAACAGTTCTATTGGCTCAGATGGGTACATGCTGTCCTCCCTGACCTGTGGGATGGCCCCGGTGACTTCCATCACTGAAGGACTCCAGCAGGTGGTCACCATGGGCCTTTTCCGAACAATTGCCTTGTTTTACCTTGGAAGTTTCGATAATATAGTTCGCCGCTGCATGGTGCAGAAAGCAAAACCTGAAGTTGTAGACAAAACTGCCTAAACCTTGCCCCTTGGATGAAAGACTGAATCCAGTGATTTGAACAGTGTGCTGCTAATGGAACACAAGTTTTGGCCTCCAGACTTTTGTATCTTGTTTTTGAATGTGTGAGATTGGACCCCGTGCTCTTCAGAAATCTGGCTGTAAGCAGAGGGACATGAGGCCATCTCTACAACTGTTAAACACTATGCAAATATGGGCCAGGACACCTTTGATTTTCTGGGCTGTAGGGGTGATAGTGTGAGAACTAATAACAGGAAAGCAGGGTAAAGAATAGCATTCCAGAACAGTAAATTCAGCTTTTCGGTCATTCTCCCATCCTACCCATAGAGATCAAGAAATGTCCTCTGTGGCGTTTCTGAGGTTTTGTTTTGTTTGTTTTTTGTTTTTGTTTTGTTTTGCTTTTTTTTTTTTTTTTTGATTTTGGGTTTTAACTTTTTATGAAAGATGGTCCGGATTTTTATTAGTCTTTTTTTCTTTTTTGTAATTTTTTTAGTGTATGTTATTCAAGGTGTGTCTTCCGAGTAGCCCGTGAGTCTGACTCTCAGCATGCCTTGCTGCGCCTGGGACTCGCTTCTGCTAGTGAAGCTGGTTTCTCTCTCTTTGATCCCATAAAATTCGAGGGGGATGAGAGAGCAGCACAGAGGGCAAGGGGTGAGTCCTTTGTGACGGCAAGCGGGGCTTTCTTGTCTTCTTAGACTGATGCTTACAACGTTTTCATTTTTATTCAAGGGGAAAGGCAGCCTCTTTACGTGTTTCGTGAAGAGAAATAAAATCTCCTAGCAGCTTAAGTTACAGTTTCTTCAGGAGCCATGATGACCTGAAGTTCACATTCCATTTCAGCTCAGTTCCTAGTGCTTATCGCTCTTCCTAGTTTTGCTTATGCTACTGTAATATTTTTGTAGAAGAAAGGAAGGAAGAAAAAAAAGATGGAGATCAGTGCAAATGTTTTTGACTTTTTTAATTAATCCATGAATTAATTAAAATMOUSE PROTEIN SEQUENCE:mP22-022.1 (Seq ID No: 3)MLLLAAAGLVAFVLLLYMVSPLISPKPLALPGAHVVDKLLQAKKDIEKHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGTSMSGKFEELEVSSFEKLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSSSKFAIRGLAEALQMEVKPYNVYVTVAYPPDTDTPGLAEENKTKPLETRLISETTAICKPEQVAKQIVKDAIQGNFNSSIGSDGYMLSSLTCGMAPVTSITEGLQQVVTMGLFRTIALFYLGSFDNIVRRCMVQKAKPEVVDKTA*MOUSE PANTHER CLASSIFICATIONS       FAMILY (SUBFAMILY)              SHORT-CHAIN DEHYDROGENASE-RELATED (FOLLICULAR VARIANT TRANSLOCATIONPROTEIN 1)       BIOLOGICAL PROCESS              Biological process unclassified (2.99.00.00.00)       MOLECULAR FUNCTIONS              Oxidoreductase (1.19.00.00.00) > Reductase (1.19.06.00.00)              Oxidoreductase (1.19.00.00.00) > Dehydrogenase (1.19.05.00.00)MOUSE GENE ONTOLOGY              No Gene OntologyMOUSE PROTEIN DOMAINS (INTERPRO SIGNATURES)              IPR002198 (SDRFAMILY)              IPR002198 (adh short)MOUSE mRNA SEQUENCE:mR22-022.2 (Seq ID No: 4)CGCCCTCGCTCGCAAACCCAAACACTCCCGGCTGCTGGTGCATGTGATCTCCCAGTAGTCGCTCGGCAGAGATGTTGCTGTTGGCCGCTGCCGGCCTCGTGGCCTTCGTGCTGCTCCTCTACATGGTGTCGCCGCTCATCAGTCCCAAGCCCCTCGCGCTGCCCGGCGCGCACGTAGTGGTCACAGGAGGCTCCAGTGGCATTGGGAAGTGCATTGCTATTGAGTGCTACAAACAAGGAGCATTTATAACTCTGGTTGCACGAAATGAGGACAAGCTACTGCAGGCGAAGAAAGACATTGAAAAGCACTCTATTAATGACAAACAGGTGGTGCTGTGTATCTCAGTTGATGTGTCTCAAGACTATAACCAAGTGGAGAATGTCATAAAGCAGGCACAAGAGAAGCTGGGTCCTGTGGACATGCTGGTCAACTGTGCAGGCACCTCTATGTCAGGAAAGTTTGAAGAGCTTGAAGTTAGTAGTTTTGAGAAATTAATGAGCATAAATTACCTGGGCAGCGTGTACCCCAGCAGGGCAGTAATCACTACCATGAAGGAGCGACGGGTGGGCAGGATCGTGTTTGTGTCCTCTCAGGCAGGACAGCTGGGACTGTTTGGTTTCACGGCCTACTCTTCATCCAAGTTTGCCATAAGAGGATTGGCAGAAGCTCTGCAGATGGAGGTGAAGCCGTACAATGTGTACGTCACTGTGGCCTACCCACCAGACACCGACACGCCGGGGCTGGCTGAGGAAAACAAAACGAAGCCCCTGGAGACCCGGCTTATCTCAGAGACCACAGCTATTTGCAAACCAGAGCAGGTGGCCAAACAAATTGTCAAAGATGCCATACAAGGAAATTTTAACAGTTCTATTGGCTCAGATGGGTACATGCTGTCCTCCCTGACCTGTGGGATGGCCCCGGTGACTTCCATCACTGAAGGACTCCAGCAGGTGGTCACCATGGGCCTTTTCCGAACAATTGCCTTGTTTTACCTTGGAAGTTTCGATAATATAGTTCGCCGCTGCATGGTGCAGAAAGCAAAACCTGAAGTTGTAGACAAAACTGCCTAAACCTTGCCCCTTGGATGAAAGACTGAATCCAGTGATTTGAACAGTGTGCTGCTAATGGAACACAAGTTTTGGCCTCCAGACTTTTGTATCTTGTTTTTGAATGTGTGAGATTGGACCCCGTGCTCTTCAGAAATCTGGCTGTAAGCAGAGGGACATGAGGCCATCTCTACAACTGTTAAACACTATGCAAATATGGGCCAGGACACCTTTGATTTTCTGGGCTGTAGGGGTGATAGTGTGAGAACTAATAACAGGAAAGCAGGGTAAAGAATAGCATTCCAGAACAGTAAATTCAGCTTTTCGGTCATTCTCCCATCCTACCCATAGAGATCAAGAAATGTCCTCTGTGGCGTTTCTGAGGTTTTGTTTTGTTTGTTTTTTGTTTTTGTTTTGTTTTGCTTTTTTTTTTTTTTTTTGATTTTGGGTTTTAACTTTTTATGAAAGATGGTCCGGATTTTTATTAGTCTTTTTTTCTTTTTTGTAATTTTTTTAGTGTATGTTATTCAAGGTGTGTCTTCCGAGTAGCCCGTGAGTCTGACTCTCAGCATGCCTTGCTGCGCCTGGGACTCGCTTCTGCTAGTGAAGCTGGTTTCTCTCTCTTTGATCCCATAAAATTCGAGGGGGATGAGAGAGCAGCACAGAGGGCAAGGGGTGAGTCCTTTGTGACGGCAAGCGGGGCTTTCTTGTCTTCTTAGACTGATGCTTACAACGTTTTCATTTTTATTCAAGGGGAAAGGCAGCCTCTTTACGTGTTTCGTGAAGAGAAATAAAATCTCCTAGCAGCTTAAGTTACAGTTTCTTCAGGAGCCATGATGACCTGAAGTTCACATTCCATTTCAGCTCAGTTCCTAGTGCTTATCGCTCTTCCTAGTTTTGCTTATGCTACTGTAATATTTTTGTAGAAGAAAGGAAGGAAGAAAAAAAAGATGGAGATCAGTGCAAATGTTTTTGACTTTTTTAATTAATCCATGAATTAATTAAAATAAAAAAATGAAAAGCATGACCTTCTTACTCTCAGAGCATACAATGGAGCTTCAGGGAAGGCAGCTGGTTGTGTACTTCTACTATTAAAAGAGGGTCAGGTTTGGAGGTTGGGTGTTGAGCGGCTCTGTCTCGCGCACTGGCACCCAGCAGTATCTTCAGCATGGTAAGGAGCCCTCTGATGGCAGCCTGTGCGCGTGCACATGCGCAAGACTGCGGTTCCATGGGCGAGCCTGCAACAAGTGCCTCAGATGAGTCCTGCCTGTATCCCACTCATCCTGTTTATTGTTCCCCAGGCTCTAGGACAGTGTTCTATGTCCTGATATTTTACCCTGTTCTCCTTGTATACAAAATACAGCATTTCAGTTCACTCCACCAGGAGAATACTACTTTGAAAGAAAAAACTTTATTGTTAAAAAACAGAAAACAGCCGGGCATGGTGACGCACGCCTTTAATCCCAGCACTCAGGAGGCAGAGGCAGGCGGACTTTTGAGTTCGAGGCCAGCCTGGTCTTCAAAGTGAGTTCCAGGACAGCCAGGGCTACACAGAGAAACCCTGTATAGGAAAAAAACCAAAACCMOUSE PROTEIN SEQUENCE:mP22-022.2 (Seq ID No: 5)MLLLAAAGLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKDIEKHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGTSMSGKFEELEVSSFEKLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSSSKFAIRGLAEALQMEVKPYNVYVTVAYPPDTDTPGLAEENKTKPLETRLISETTAICKPEQVAKQIVKDAIQGNFNSSIGSDGYMLSSLTCGMAPVTSITEGLQQVVTMGLFRTIALFYLGSFDNIVRRCMVQKAKPEVVDKTA*MOUSE PANTHER CLASSIFICATIONS       FAMILY (SUBFAMILY)              SHORT-CHAIN DEHYDROGENASE-RELATED (FOLLICULAR VARIANT TRANSLOCATIONPROTEIN 1)       BIOLOGICAL PROCESS              Biological process unclassified (2.99.00.00.00)       MOLECULAR FUNCTIONS              Oxidoreductase (1.19.00.00.00) > Reductase (1.19.06.00.00)              Oxidoreductase (1.19.00.00.00) > Dehydrogenase (1.19.05.00.00)MOUSE GENE ONTOLOGY       No Gene OntologyMOUSE PROTEIN DOMAINS (INTERPRO SIGNATURES)              IPR002198 (SDRFAMILY)              IPR002347 (GDHRDH)              IPR002198 (adh short)HUMAN GENOMIC SEQUENCE:hD22-022 (Seq ID No: 6)GGCTCCTCCTCTTCCCCTCCGCCGCGGCCCGCCCCGGCCCGCAAACCCAAACACTCCAGGCGCCCGCCCGCCGCGCGTGATTCTCGCCTCGCCGCAGCCCAGCCCTGCGCGCCTTGCCCGGCGGCCCCCGCCCGGCCGCTCCGGGCCCCTGGCCCCGCGGAGCGATGCTGCTGCTGGCTGCCGCCTTCCTCGTGGCCTTCGTGCTGCTGCTGTACATGGTGTCTCCGCTCATCAGCCCCAAGCCCCTCGCCCTGCCCGGGGCGCATGTGGTGGTGAGTGGCCTCCTGTTGCTGCCCCCCGACTTACCGGCCCGCGCGGCCTTTCCGCCGCCGAGGCCGCGTAGCCTACGTCCCTTTTTCCAGGCCGCGGTCCCCAGGAAGGCATGGCCAAATGGGGAAGGTCACCTGCCGCCGTCCACCCCGGCGCTTTTCCCCCGGCCCCGGCACCCGGCCTCGCGGACCCGCCCTCCGCAGCCTCGGGCTCCTCCTAGGGCCGGAGAGCGTGCGACGGGGGACCCCGCCGGCCGCAGGGTTCCCGGGGCCCCAGGGGTTCTGTGGCTGCTCGTGAATCCATGCAACATCCCTGGGATGTGGATGTTTTGTCCTCAGTTTTTCCGATGAGTCAACTGAGGCACAGAGAGGCTGAGAAACTTTGCCAAGGACACAGCGGTCGGTGGTGTGCAGGGTGCGGCGCGCGGCCCCGGGCGGGGGCAGACAGCGGGGAAGTGGGGTCCCAGCCGCCGGGACCCGCCGAGGCAGCTCGGAACTGGAAGATGGCCTGTGCGAGTGACGGGAAGAGCCGCTGCCAGAGGATTCCAGGAAGTGACTCACCTGGGGAAACTGCTCAGAACCCAGCGGGCTGGCGGTGGTGGCTTAGCGGTATTGGGACGCCTGTCCCGTCTACACTGCTTGTCTCTGAGCTCAGCGTGGCATCTGCTGATTGCTGCTCCAATGCAATCCTTTGCTGTTTTCTAGTGGGAAGGATGAGCTAAACGACAAGGCTTGTGTGCGAGGAATGAAGGAGAGGTGGATAGGTGTGATTTATTTCTTGGCGGAAGCTCGCATATTCAGCGATCCCTGTTCTGCAAATGTGGCACCTTTCTTAAACAGAGAGAATGCCTCCTTGCCTGCGCCCAGCACTTTCCCGTTTGCAGTGGCTTTCTCACGAGCATTCTCGTTTGGATCTCCCAAACCCGAGGCACAGTGAGGCGAGGAGTTAGGAGTAAGGAGGGTTGGTTACAAAATTGGCCGCACACCTCTTCCTGTCCTATCTCTGCACCGGAGATCCGAGCCTCCCCGCTGAGCTGGTATAAAATAAGATGGTCGTTTTTCTTAGTATGCTTTAAATCTGTACAAGGGTTTGTGAATGAGAAAATGTATCTGTTTAATTTCTCCTTTGTAAAGCTATTAGCTTTTTCCAACACCTCCTGTTCCTAATGGGGAAAGAGTGTGGATTCATTACAAAAAATAAATAAGAGAAAGGCAAAACTTGACACTCTAAATTCTGAAAGTTTTACATCCGCAAGAGAACTGCTGCCTCAAAAGCGTGGCTTTAAACCTTGGATCCTTTCAGAGCTTGAGTTTATAGAGCATAACTTTGCAAAAACTAAAGCTAAACGCAGAATGAAAATTGGAATTCCTTATTTGTAAGACAGTTTCACTGAGCCTTGACTCCAGTCCTTCCAGCCCCATCCCGCGGCAGGTCATAGGTGAGATAATAAATGCTGTGTCTGTTCAGGTGGACCAAGAAGAATTTATTTTTACCATCCCGCTTTAATACGCAGGATTATTATTTCACACTCTAAGTAATGTGAGAATGACATGAATAGTTCACATGGTGTCACCATCTGTCTTCTTTTTTAATGTCATAAGAAGAGTGAAAAGTGTAATTGTTCTTGAGATTTGTTAGGAGTTGACTGTGGTATTGTTGGGAGAGGGAGCTGATGGTTAAACTGTCTGCCCATACATAATTAAGAACAAACTTATAACAATTGTTTCATTTTTAAAACAATTTTATATACTAGTGTTTTCTATCTAGTTACGGTAGTAAAATTGCAGGAAAAAAGCAGAAAATCACCCACCTCAGCCTCCGAAAGTGCTGGGATTACAGGCGCGAGCCATCGCGCCCGGCCAACAACAGCTATATTTTTACAGTAATCTGCTGATAACTGGCTGATTACCGACCAAATAAATCTCTTCAGTGGTGGCAGGTTGAAGCTAAAAAGAAGTAAGGGATGCCTATGAGTCCCATAGAGGTAGGTGCATTTGCGTAGGAGACACTTCCCAATGATGTTAAAATCCTAACATGGAGTCAGAGATCTTCCTCCCAGCATGATTTATGTATAACAGTGAATATTAGGAAAAATCTAAATGTCTGGTTATAGGGAAACGTTGAAGTTTTGATGCAGCTATTTGATGAAGTATTGTGAAACCTTTTCGTTTTTTGACAAATAAGACATTACAATATAATTTTTTAAAAACAGGAGACAATACTATGCAATATTATGTAATTTGCATAGGGACAGTGACTAGAACGATATGGCCGGGTACAGTGGCTCACTCCTATAATCCCAGCACTTTGGGAGGTCAAGGAGAGTGCATAACTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGTTGGGCGTGCTGGCGCACGCCTGTAATCCCCACTACTTGGGTGTCTGAGACAAGAGAATCGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCTGAGATCGTGCCACTGCACTCCAGCCTGGGTGACTGAGCAAGACTGTCTCAAAAAAAAAAAAAGAAAAATAATGTTGCATTGTTCACTTATTCAGTGAAATATATAATATATATTGAGCCCTCCCCAGGCTAAGTGCTAGGAATATAGTGGAGAACAGAAAAATAATTGGTATTTTTAATGGAGTTTATGGGTAGGTGATAGGAGAGGTGGTTGTGAATCAGATAATCACACAAATAAATCTAGAGCTGTTTATTATGTGCATGTCATAAAGAAGAAATACAGTGCTGAAAAGTGTGTCAGTGTGGGGGCAGGGGAGACAGTGAAGGCTTTCCTGAGGAAGTGGTATTTGAGCTGAGATTTGATGGGCGAGTAGGTGTCAGATGAAGTGGGGAGAAGAGCATTCGTTGCAAGGGAAGTAGGATGTGCCAAGGTACTGTGGTTGGAGGGTTTTTACAGTAATCTTCTGCTGATAACTGGCTGATTACCCACCAAATAAATCTCTTCAGTGGTGGCACGTTGAAGCTAAAAAGAAGTAAGGGATGCCTATGAGTCCCATAGAGATAGGTGCATTTGCGTAGGAGACACTTCCCAATCATGTTAAAATCCTAACATGGAGTCAGAGATCTTCCTCCCAGCATGATTTATGTATAACAGTGAATATTAGGAATAATTCCATAATTGAAAGCCAGTATAGCTGAACTGTAGATAGGGGTAGAATAGTGCAAGAAGAGCTTTACTTTTCAGGATTTCCTTGTGATTGTATATTACTTTTATACTAAGCAGTCATTTCAAATAAATATTCAGGTGGCCATTCTTTTCATCTGTTGTAGAGCTAATCTTGCATAAATGTGCATTAAGAAAATAAGATTCAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATGCAGCCATAAAAAATGATGAGTTCATATCCTTTGTAGGGACATGGATGAAATTGGAAACCATCATTCTCAGTAAACTATCGCAAGAACAAAAAACCAAACACCGCATATTCTCACTCATAGGTGGGAATTGAACAATGAGATCACATGGACACAGGAAGGGGAATATCACACTCTGGGGACTGTGGTGGGGTCGGGGGAGGGGGGAGGGATAGCATTGGGAGATATACCTAATGCTAGATGACACATTAGTGGGTGCAGTGCACCAGCATGGCACATGTATACATATGTAACTAACCTGCACAATGTGCACATGTACCCTAAAACTTAGAGTATAATAAAAAAAAAAAAAAGAAAAAAAAAAAGAAAATAAGATTCATTTGGATTTGGAATCAGAGGCAGACTAATGTATTATTTATGAGCTAGACTTATAGGGCACTTTTCCACCAGTGAACTCAGAAAAATATTATAGGTGTGCAATTTATGGTTCCATAAGAAAACAGTCAAAGCAGCAGGCCTTGCTGATAGTATCTTTCATGCTTACACTTACTCCAGTCATTAAGTTTGGGATGAAGAAGTTAACAACAGCTAATCATTTAGTTCTTGTAGATTCATTTTAAGAGCCTGTCATAGTTGTTTTTTATAAAAACTTCCTACAGAGGGGAGATTTCAAGTGCTAAGAATATTTTATGATTTTGTTTTAGGTTACAGGAGGTTCCAGTGGCATCGGGAAGTGCATTGCTATCGAGTGCTATAAACAAGGAGCTTTTATAACTCTGGTTGCACGAAATGAGGTAAGGCTTCTAGGTTCATTATTACTGACTTGCTTCTTCGACTTGAAATTAGTCAAAGAGGCTGTGCTAAACATCTTAGCATTCACACCTAGAAAGCGCTTCTTCCTTGATGTGAGATGTGTTTCCTGAACTACTGATTCTCTCTAGTATTTAGGCCAAACACTTCTCTGTTGAAATCAGGTCGGCCCCACAAGTATTTATTTAGTACCATTGGCATATTAGGCAACATCATCATAGATACTGCAGATCCTGAGATGGGAGAGGCCAAGGTCTAGTTGAAGGAGCACACCTGGCCATTGGAAGCCAGGGAGGGCCCTTGGCCAGGTCAGAAGTGCAGGAAGCAGTGATTCTGGAGCTGATACCTGAAGGTGTGTAGGTGTTTCTCTATAATTTTTCACTACGATTTGCTTAGGACATGATATATATCTCTAGTGAAATCTATACACCATAGAGGAACCTCGTCCCTCCTTAGAAGTTTAGCAAAATGTGTTTTTCTGTATTAAGTCAACACAGAATCTGTTTTTATTTTTTGTCAGGGTTTGTTTTTGTCTTGCCAAAGTTGTTTTTAGAGCACAAAGCAGTGACACTGTGCACGTGAACTGTCATGACGTCCTCTTGCTCCCCATATGGGGACTGGAGGAAAGTGACCACACAGCTGGCTCGTCCGCTGCAGCAATTCTAGTGCTTGACACGTAGTACATGCTCAGACATGTTTGTTGAATGAAGAAATGAAGGGAGGAATGATGGAGTGCCTGGGAATGTCAGCATGGCATACTTCCATGGGGATCTTGGATTCACCCATGTGCAAGGAGGGTGATAGTATGGTAACTCCTCAAATGGGTGGAGGGCTGGACAGGACCCATTAGGAATGGTAGGCCAGGAAGGGCCTTGGGGGAAAATTTAAATAATGTCGCAGACTTAGTCTTGGACCTCTATAATTTCTTTTATTTTTTTCTTTTTTCTTGAGACAGCATCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTTAGCTTCCTGAGTAGCTGGGACTACAGGCGCCCACCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGTCAGGCTGGTCTGGAACTCCTGACCTTGTGATCCGCCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACACCTGGCCTGGACGTCTATAACTTCTTTTGCAAACCAAGAAAGACAAAATTAGCTACCTTTTATTTATAGCTTGACTTTTCTAACAATGAATTTGCTTTGGCATTGAAGCCACCTTACATAAATGAAAACACAAATTTGATGAAATGGCATTTTGTGAGTTTTAAACACCAGTTTTGATGCAAGTAAATAAAAGTGGAGGCAGAGAAGGCCAGCATTTCAGGCCCCCAGGAGCTCATATGGGGCCCTTGCATTGCTAGAAATGAATGAACTGAATGAAGAACCTGTGGTGTTGAGTAATTCATTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTTTTGCTCTGTAACCCAGGCTGGTGTGCAGTGGCGCTGTCTTGGCTCACTGCAACCTCCACCTCCGGAATACCTGGGATTACAGGTGTGTGTAACCACACCTGGCTGATTTGTGTGTGTGTGTGTGTGTATATATATTTATATATATATAAAATATATATTTTTATTATATATATTATATATTATATATATAAAAATATATATTTTTATTATATATATTATATATTATATATATATAAATATATATTTTTATTATATATATTATATATATATAAAATATATATTTTTATTATATATATTATATATTATATATATATTATATATATATATATTTTTTTTTTAGTAGAGACAGGGTTTTACTATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTTAAGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGCTTACAGGCGTGAGCCACTGCGCCCGGCCTCACTGTGTCACCCAGGCTGGAGTGCAGTGACACAATCTCGGCTCACTGCAACCTCCGCCTCCCAGGCTCAACCAATCCTCTCACTTCAGCCTCTTGAGTATCTGGGACCACAGGTGCTCGCCACCATGCTTGGCTAAGTTTTTGTATTTTTGGTAGAGACGGGGCTTCACCATGTTGCCCAGGCTGGTCTCAAACTCCTGAGCTTGGGTGATCCACTCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTGAGCCACCATGCCTGGCTGAGAAATTCTTTCTTTTCTAATGTAATTTTTAATTCCAGTCTTTGCAAAGTCAAGCTGTATGTATCTTTAGTCATAGGACAATATTATTTCATTATAGACATATTCAGGTTTAGAAACTCTGCATGCCTTTTGGAAGAATTCGCCTCTCCTTTGGTTCCTCTCTATTGCATGATATTATTTAAGTTACTTTTTACAGCAAATTAAGATAATCTGATATCTGTTTTCTTGAGACTAAGTAAAACAAACAAAATTAGGACCTTGGAAGAATTACATAATTACACAGGTAACCTTGCTTAAGAGTATTTTATAGTAGCCAGGCCTAGTTTACCCAGTCTATCCAGAAAGTGATTCTTACTATGTTTGGGTTTATAGTAGAAGAAGAAAATATTGGACAAAAAGCAGTATTGACAGGGAGTCACACATACCCTCAACTTTGGGGAGCAGTACATATTAATAGAGTTGTTCTTGTCTTATATCACAACTAAATAATAAGACATTTATTAGAACTGTAGAGTCAGCCTCAGCAATTAGTACTGTTAACTGGGATTTTGAGGTTTATCTGTTTTCTACTATCTTTCTCTAATTAATTTTCAAACTTTTATCACTTATTCATAGCTTAACATACTTCACAACTTCTTTCTTTCATAGGCTGTGGCCCAGTCTGTCTATGCAATGTAGATACTGTTTTGTGTGTTTTCTGGAATTTAATACATACATATAGAAATAATTGCTTTTTTTCTCTCCTTTGCAATAAACGGACATGCATATAGACGGTCATCACGACTAATTATTCTGTATTGCTTTCAGGATAAGCTGCTGCAGGCAAAGAAAGAAATTGAAATGCACTCTATTAATGACAAACAGGTAAATCTCTGTCTTCAGAATGCATTTTCTGTATAACTCAGCACAGCTGTATAAAGGAAAAACAGAGTTACTTCACCTGTGAATAGTTAATTGAAAGCATATATGTACTGTTTTTTAAAAGGTGGAATTGTTTGAATGGTCTAGTAACTCAGAATATCACACACACGCAAAATGAATAGACTCCCACACACATTCATATCTACAAATGGTCAAATAACAGAATGTTTTACTGGCAAATAATTTCATTTTAATTTTTTTTTTAATGAACTTTATACAAATGCTTAAGAGGAAAGGAATATTTAAAATTTATTTGGTTATGGAATTTTTGATGAATAAAATGCTATTTATATTTCAGTATAAAACATAATAGCAAATTAATAATCACACACCCATCACCCAGCCTAAGAAGTAGAAATGATCAGGGTCTCTGAAGCCCCCACAGCAGCCTTGTCCCTCTTTTCTTGTTCCTAGAGGGGCAAATGCCAACCCGATTTTTGGTGTTAATCCTTTCTTTTTCTTTTCTTTTTTCTTTCCTTTTTTTTTTTTTTTTTTTTTTTGAGGCAGTGTCTCAATCTGTCATCCAGGCTGGAGTGCAGGGGTGCGATCTCAGCTCACTGCAGCCTCGACCTCCTGGGCTCAAGCAGTCCTCCCACCTCAGCCTCCCTAGTAGCTGAGATTATAGACACGTGCCATCATGCATGGCTAATTTTTGTATTTTTGGTAGAGATGGGGTTTCGCCATGTTGCCCAGGCTGGTCTTCAACTCCTGGGCTCAAGCAGTCCGCCTACCTCTGCCTCCCAAAGTGCTGGTATTATAGGAGTGAGCCACTGTGCCCTGCCTCTTTTTCTTTTTAATTTTACCATATATGCACATAACTCTAAATAATAATATATTGTTTAGTTCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCTCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCCATCTTGGCTCACTGCAACCTCCACCTCTCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGTGTGCCACCACACCCGGCTAATTTTTTTTGTATTTTTAGTAGAGACAGGGTTTTACCATGTTTGTCAGGCTAGTCTCAAACTCCTGACCTCAGGTGATCTGCCTGCCTTGGCCTCCCAAAGTCCTGTGATTATGGGCGTGAGCCACCATGCCTGGCCAATATACTTAGTTCTACTTCTTTTATTATATCATTCTTATTTTTTAACAGCTTTATGAGATATAATTTATATACCATACAGTTGACCCATTTAAAATATATAATTCAATGATTTTTAATGTATTCATAGAGTTGTGCAACTGTCATCAAAATCAATTTTAGAATGTTTTCCTCACCCCGTGAAGAATCTCCATGTGTATTAGCAGTCACTTGCCATTTCCTCCCAGCCTCTTCTCAGCTAGGCAGTCACTCATCTACTTTCTTTCTCTATAGATTTGTATAACTTCCTTCTTTATGCTTCTTATGCAACTTGATTTCTTCACTCAATATTATTATTATTTATTTCTTATTTATTTATTTATTTTTGAGATGGAGTCTCGCTCTGTTGCCCAGTCTGGAGTGCAGTGGCACAATCTCAGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCCTCAGCTTCCTGGGTAGTTGGGATTACAGGCGCGCGTCACTACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGATCAGGCTGGTCTCGAACTCCCAACCTCGTGATCCGCCCGCCTCAGCCTCTGAAAGTGCTGGGATTACAGGTGTGAGCCACCATGCCCAGACCACTCAATATTATTCTTTAGGCCAGGTGCGGTGGCTCATGCCTGTAATCCCAACATTTTGAGAGGCCGAGACGGGCAAATCAGTTGAAGGTAGGTGTTTGAGATCAGCCTGGACAAAGTCGTGAAACCCTGTCTCTACTAAAAATATAAAAAGTTAGCTGCACCTGTAACCCCAGCTACTCAGGAGGGAGGCTGAGGCAGGAGAATCACTTGGATCTGGGAGGCAAAGCTTGAGGTGAGCAGAGATTGCACCGCTGTACTCCAGCCTGGGTAACAGAGGCAGACTCCATCTCAAAAAAAAAAATATATATATATATATATATATGTATGTATGTATGTATGTATATATATGTGTATATATATATATAATTTTAAAAATTCATTTATGTTGCTGCAAAAAGTTGGAGTAAATTTTTTTTTTTTTACTGCTGCGTAGTATTCTATTGTATGTATAGACTACATTTTGTTCATCAGTTCAGCAATTGGTGGATATTTAGTTTGTTCCCAGTATTTTTGTTAGTTTGTTTTGTTTTTTACTATTAGAAAAGCTTTCAGTATTCTCTTTGTGCACGTGTGCAAGAATGGTACATACCCAGAAATGGAATTGCAGAGCTGTAGTGTATGCAGTTCTTCAACCTCACCAAAGTGGTTAAGCTCCCATAAGTAGGAATGCGGTTTCTGTTGCGCCACATCCCTGCCAATACTTGGTATTGACAGACTTTTTACTTTTTGCCTTTCTGATGAGTTTTGAATAGTATTTCACTGTGGTATTCATTGACTTTTTCCCTTCTAGAATGTTAGAGATCTTTCCATGTGCATTAAGTAAATTTGCCTTAAATTGCTGCAGCCTAGGATTGAAGTACACCAGAGCTTATTCCGTCAGGTCCCTGCTATTGAGCTGTTTCCATTCTTTTTATTTTATTTTGTATTTTTATTTTTGCAATTGCAGTCTGTGCTGCAAGTAAAAATCCTTGTGTATATCTTCTGCACATGTGAGTTTTTCTCTAAGACTGTGGTCTTTACCCCCTTCTCTGAAGCCCACAAGCATTGGAAAAACACCAGCTCTGTAAATTGCCCCGTTTTTTCCCGTATTCCTGTAATATCTGATAGACGAAGGAGTATGGTGTGAAGTCATGGAGTCAGTGTTCAGGGCCAAGGCCAGTCTTGCCTGCTGCCAACACTGTCTCCGCTCTGGGCTTCCTCATCATGACACCTTCTACCTCTTCATCTACCAAAGGACTTTAGGTCAGGTGGAAAACTTACCTTTCACATCAAGGAAGGGAGATAGGGCTGGGGCAGGCGAGAATGAGCTTGATCCTTCTGCCCTGCCAGGCTTCTAGGGACCTTTTGTGTGTGTGTGTGACTTGTTAACATTTTTTTGTTCTGAGATTTCACTTGTCTGTGGCATAGATTTTATTATTAGTAACTGATCTAATACTGCATGAAAAGGCTTGTTTTAAAATTAATCATATGATTACTACTGCCTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGTTGCCCACGCTGGTGTGCAATGGCATGATCTCAGCTGACTGCAGCCTCTATCTCCCAGGGTCAAGCAATTCTCCTGCCTCAGTCTCCTGAGTAGCTGGGATTATAAGTGCCCACCACCACGCCAGGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTAGGCCAGGCTGGTCTCAAACTCCTGACCTCAAATGATCTACCTGCCTCGGCCTCCCAAAGTGCTGGGATTATAGGCGTGAGCCACCGCGCCTGGCCGATTACTACTACCTTTAAAACAATGTTTTCTATCTGAGGATGTTGGGATAAAATCCACTCTAGGTATACATTACAACCAAGGGCAACCCCTCTAGACTAGAATGCTGGAGGTTATATTTGCAAAGAGGGCTGTTTCCTTTTCTTAGGAATTTTGATCATTTGGACAGGATTCCTTCTTGAAAGGAATCAGCACTGAGGCCCTTATATGGAATATTTCCATCACTCCCTAGGGTTGGCCTGTGCCCTTTCACAGTTCCTTCCATCCTCCATGCCTGGCTGTGGGCAACCCCTGATCTGCCTTCTGTCACTATAGATTAGTGGCATTTCAAGAGGAGCATTTATATATTTTTAAAAAGATTCCTCAGAGTTTTAACTCCAAAAGCTGCCAAGAAAATTAGATTCTGCTAATTGCATCATCAGCAAACACTGAAATCTGTTCATTCAATATTGGCTTCCTTCTGTATTCAATGAACTGTCTTTTCTTTAAAAAATATCTTTAAGAAATAGTTTGGTACCTGCAAAACTTTGATCACTTTTTTTCTTTTTTAACAGGTGGTACTTTGCATATCAGTTGATGTATCTCAAGACTATAACCAAGTAGAGAATGTCATAAAACAAGTAAGAGGTTGGGCTAATTGGAATTCACCAATGTGCTTGACTTTTGATTTGTTCTTGCCATTTTGCTATGTGGCTTGGAATGGACACAACTTCTCTGTAGGTTTAATAGTTTTGTAAATTTTATTTATCAGCATGGATTTGCTGCTGAGTGGTTTTTCTTCTCTGTTTCTTAATGCCTGCTCTGCTACATTTTTCTAGGCACAGGAGAAACTGGGTCCAGTGGACATGCTGGTAAATTGTGCAGGAATGGCAGTGTCAGGAAAATTTGAAGATCTTGAAGTTAGTACCTTTGAAGTAAGTAAAAATGTTTGCTCACTGCAGTAGCACATATGCTAAAAGCAGAGCAAGCTACGGGTAAAAGCTTTAAGAATCAATTAGATGAATGCATTCAGATGTCCATGGAAGCTTTAGAAGACTCTAGAGGAAGGCTGAACAAGGTGAAGCTGAACAAGGTTTTCATCCCAGTGTCAGGACCATTGAAGCTTAAGAGTTTAGACATTTTACAGCTGAGAAAACCAGCTAAAATGGGAATGGACCTTCTAATCTGACACAGATTACTGTAGCAGTTCACTGAGGTCATATTTTCAAGAGAACACTTTGTAACCTAAGAGATGCCGGATGTTCCTATCAAACATCAGTATTATTAACAAGGAGAAACCAAAAAAGTTGAAGGACAGACTCACTAGAGTTCTCAAATCAAGATAAAAAGATACTGCATCTTATTGATGTTTCTATTTTTAATCAGGTTTACCAAGGAACTTCTCTTGGTAATTTATTTCAGCACCAAAGAAATGAACACTAGATTTGAAATTTTTATTTTTTCTTTTTTTGAGATGGAATTTCACTCTGTCACTCAGGCTGGAGTGCAGTGGCGTGATCTCAGCTCACTGCAACCTCCACCTCTCAAGTTCAAGTGATTCTCCTGCTTCAGCCTCCCTAGTAGCTGGGATTACAGGCACATGTCACCACACCCAGCTAATTTTTTTTATTTTAGTAGAGATGGGTTTACGCCACGTTGGCCCGGCTGGTCTCAAACTCCTGACCTCAGGTGACTGGCCCACCTCTACCTCCCAAAGTGCTGGGAGTACAGGCATGAGCCACCAGGCCCGGCCTGAAATGTTTTTAAAATGGAAAACGTTTTTTAGTTGCCATCGCATCAACAATCTTTTTCTTCCTTTTTTTTGAGACAGAGTCTTGCTCTGTCGCTGAGGCTGGAGTACAGTGGCACGATCTCGGCTCACTGCAACCTCTGCCTCCCGGGCTCAAGCGGAGTGTCCTCCAGCCTCCTGTGAGGATGAAGCTGGGGAGTGTGTTGGTGTCTTCGTGTGCGCCGTCTAGACAGACTTTCCCTTAAACCTCTCTCTTTATCTAGACTTACTATCCCTAGAAACAGAACCTCCAGTCTCCTGCCAGGCTGGAAGAGGGGTACAGATCTACCCTGTGGAGAGGGGAAAAACATCTAAGATCTAACTGCCTTTTTTTTTCATTGTCCTACATTATTTTTTTAATTTGAAGTGAAATTCATATAACATAAAATTAACTGTTTTTAAAGTGAGCCATGCAGAGGGATTCAGCATATTCACAATGAGGTGCACCCACCCCCTCCGCCTAGTTCTAAAGCATATGCATCACCCATAGGGCGGCCCTCACCTGGTAAGCAGTTGCTCCCCATCCCTGCTCACCCCCACACCCAATCTCTGACAACCACCAATCTGTATTCTGTCTCTGGTCATTTCGTATGATTGGAATCATGATATGTGCACTTCTGTGTCTGACCTCTTTCTCTTAGCATCAGTTTTTGAGGCTCATCCACATGTAGCATATATGGGTGCCTCATTCCTTTTTATACGGTGGTGATATTCCTTTGTATGGATCGACCACATTCTGTTTAGCTATTCATCATCGATGGCCATTTGGGCTGTGTCTAGCTGACTGCTTATTAAATAGACTCTTAGTCCCTACTCCTGTCTCAGCCCCATGCCAGCCCACCCTTCCCTCCACCCCAGAGACTCTTGCAGCTGGAGCCTTTTGGGGTTCTGTAGTAGAATCTGGCTTTTTAGTTTCTCCACTCCCCGCTTAGCATTTAGTTTTTTGTGGTCTGCTAAGTTAGTTATCCCTCCTCAACCTGTTCTTCAGCTTCCAAAAGGTTATTGCTGTTATTTTTATTCTTATTTTCTTTGTTCTTGTGTGTTCTTGCCTTAAAAAACATCTCTTTACGGAGATTTTAGTAAGGTTTCTAAAGGGAGCCAAAGTAAACACAGGCGTTCAGTGTGACGTCTTTTTTCAGATATTCTTTTAGAACTTTCTTTTTTTTTTGGAGACGGAGTCTTACTCTGTCACCCAGGCTGGAGTGCAGTGGCTCAATCTCGGGTCACTGCAGCCTCCACTTCCCAGGCTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGTTGCCCACCACTATGCCTGGCTAATTTTTTTTTTTTTTTTTTTGTATTTTTAGTAGAGTCGGGTTTTCACCATGTTGGTCACGCTGGTCTCGAACTCCTGACCTCAGGTAATCCACCTACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTGCCCGGCTTAGAACATTTTTTATTATCAAAACAATATTATCTTACGAAAACACACTTTTGGAAAAAAAAGAGAATCCCAGCATCCTAACTCAGTCACTTATGATCTTCTGTATTTCCTTGGTCTTCCCTCTGAGCATGTGTACTTTTACTTAACCTTTGAAGTAATTACAGTTACAGCATATATACAGTCTAGCTTCTGCTTTTTAAACTTAAATAGCATAGATATTTTTCCCTGTCACTCCCAGTGTTTCTGGTCATCATTTAAAACAATTATCTAGGCCAAGTACAGTGGCTCACACCTGTAATCCCAACACTTTGGGAGGCCGAGGCAGGCAGATCACTTGAGGTCAGGAGTTCGAGACCAGCCTGCCCAACATGGCGAAACCCTATCTCTACTAAAAATACAAAAAATTAGCTAGGCATGGTGGCTGGCGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAGAGGTTACAGTGAGCCAAGATCACACCACTGTACTCCAGCCTGGGTGACAAGAGCAAAACTCCATTTCAAACAAATACAAACAAACAACAATAAAAAAATCTAATATTCTCTTGAATTAAGATATTATGATTGTATGTTCATGTTCTGTTCATAATATGAAAAAAAATTATGATTGATCTCAAGTTCCACAATTGAGGTATTTAGTTTTTATTTACATGATGATCTAATATTTTTACAAATATTTGAATATTTGAAACATTTTAATGCAAGTATTATTAAATTTTCGAGTTAAAATTTAAGGTTTTTAAGAGCTCAGGCTAGGCGCAGTGGCTCATGCCTGTAATCCCATCACTTTGGGAGGTCAAGGCAGGAGTACTGCTGGAGCCCAGGAGTTCAAGACCAGCCTAGGCAAAATAAAAGGACCCTGTTACTACAAAAAATACAAAAATTAGCTGGACGTGGTGGCATGTGCCTGTAGTCCCAGGTCCTCAAGAGGCTGAGGCAGGAGGATTGCTTGAGCCCAGGAGATTGAGACTGCAGTAAGCCAAGGTTGCACCATTGCACTTCAGCCTGGGTGACAGAGTGAGACCCCGTCTCTAAAAAAAATGATAATAGTAAAAAAGCAAAAAATAAATAAATAAAAATTAAAAGCTTCCAAGACAAGGAGAAAATACACTATTAGTACTCTTACCCATCATAATGGGAGAGCCAGTGGTTCTTGAGGTCCAGGACTGTGCTAGCGCTTGTGTTTTCTCTTTTAATCTTTGCAACAGCCCTATGCGGTCATACCCTTGTTGACCTTGTTTACAGCCAAGAAAATAAGTAGAATGTCTGACTTTCTTATTCATCATCAAATAGGCAATAAATGGGAGACCCAAGGCTTGAAACCAAAACTTTAAATCACCCTCCTACTCTGTGTTTTTCTTATAGCTTAGAACTAATAGGGCTACAAATACTTGGAACCTCTTTCCTAAAACTGTCTTTCAGAAAGTACTACCCACAAACATGCAGTATACTTTTTATAAGCAGAAAACTAACTTTGACCAGTTTTCAGGAAAAACATTAACTGCTGTCATGGTCAGAATGCAAGACTAGACTGAAACAGTCTTCAAATGGTAGGTCCTGAGTCTTCAAATGCTAGGTCTCAAATCACATTTCATTTATATCATCATGTCATCATTCATTCATTCAGCAAGCCTGTTGGGCTTCCCAGTCACTTGAGCTTGCATTGAAGAACTGAAATCCAGAAAGCAGACTAAATTCTCCATGTGCACAGCCTTGAGGCTTTTGACCTCATGTGGCCTCTTTGTTCCCTGCAGAGGTTAATGAGCATCAATTACCTGGGCAGCGTGTACCCCAGCCGGGCCGTGATCACCACCATGAAGGAGCGCCGGGTGGGCAGGATCGTGTTTGTGTCCTCCCAGGCAGGACAGTTGGGATTATTCGGTTTCACAGCCTACTCTGCATCCAAGTTTGCCATAAGGGGATTGCCAGAAGCTTTGCAGATGGAGGTAAAAGTTGTATTCATTTTTGTATTTATTCCTCTCCGCTCAGCAATATACATTCCGCTTTAGTTTTATAGCTTCTTTACATGTGTTGTTGTATTAAATTAGAGATTTTTAGGTTTGACATTGGTGAAAGAGAATTGGCTCAACCCTGAGTTTTGCAGTTAACATTTTTCATTGCATGAAGACTATAGTTAACGACAGATGCAAAATGGTAATGGGATTTTTGCTTGTTTAACTTAATACACAAAATATTAGTGATATCTTCATAGTGTTATTAGTCTAATACTGTGTGAATGTGAGTAAGGTTAACCAGATATTTTATTTTATAGAGATTTTTCTTTAACAAGAAGTTTGTCCTTATGACTGAATAATACATGAAATTAGTATATGTTTGAGGGAAGAGCTTGAATCAGCTGCTAATTTTTAGCTTTTAGACAAGTCATTTAACTTGCTCTCAGTTTCCTCATCTGTAAAATGGGAGGGTTGGAATAAAGCAATAATTTGACTCTCCCAATATTTATATTTTTATATCTTAAAGAATTGTTGGGAAAATGAATGCTTTTTATTTACATAGTTAATGGAACATTTTGTGGAAGAAGGATGTAGTTAGGATTTGCATCAAAATAGCGTCTGTCATGATGAGTGCAACTTTACACCTCAGCTGCTTGAAGCCGACTTCCACATTATTGTCACACAGGAATGCTTAGAGAGCATCACATACGTATCTACCCAAAAATCACATGCTGAAAAAGGCAAGGGAAAGTTCTTTCTATTGCTGTGTACAGTCATCCCCTCTTATCCGCAAGGGATGTGAGCTAAGACCCCCAGTGGATGCCTAAAATGTTAAGAGCCCAGAAGAGTATTCACTGTGGCCAACCCTCTTATAGTAAGAGTGTGCTTTTGGGAATCCTGGTTGATGATTTAGATCAGGGGTTGACAGAACTTTCACCAAAGGGCAGACAGTATATATGTTAGGTTTTAAAGGCTGAATGGTGCCTAATACAGCTACTTAAGTAGGCTATGATACCAGGAAAGCAGCCTTACTAGACAATGTGTAAATGAACAATTGTCACTGTGTTCCAATAAAACTTTACTTATAAAAAACAGGCAGAGGGCCAGATCTGGCTCATAGGCCATAATTTGCTGACCCCTGTTTAGAAGACCCCATAAGAGACCTTGATGGTGTGTGATAGAGCACCACATTGGTGAGATATGGGACGAGCGTTGCAGTACAGATGAGCTGCTGGGACAGCGACAGTCCTGATGTGCCGCGTAGGGACTGATAGATCATGCCATTCTCATACCATAGGAACCAGCCACAGATTTTATTGTTATCAACTGGCCTAATACTCTTAATAATATATCGTGATAATATGCTTAGCCAATAGGACACTGATGTCTGTGAAATTTCAAACAAGAATACTGGTGTTTCTTTTGAAGTTTTTAACTTTGAAAAGTCCTTTTGTGAATAACTGTTTTATTTATTTTTATTTTATTATTTTTTTTTAGAGACAGCGTCTCTCTTTGTTGCCCAGGCTGGAGCGCAGTGGCACAATCATAGCTCACTGCAGCCCTGAGCTCCTTGGCTCAAGTGATCCTCCTGTCTCAGCCTCCCAAGTAGCTAAGACCACAAGTGCACACTACCATGCCTGGCTAATTTTTAAAATTTTTTGTAGAGAAGGGGTCTCACTGTGTTGCCAAAGCTGGTCTCAAACGCCTAAGCTCAAACAATCTTCTGGCTTTAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCAGCACACCCAGCCACCATTTTATAAAGTTTTGTAAAGTATGTGAGGGAGATGTTGTGATGCCACCTGATGAGAGGAAAACCCAGTTTTCAGTAAATTCAGTGTGTTGCTCAAAGTCACATAGTTACTTAGTGACAGAAATCACAACACGATCCAAGCCTTGACCCCAGGTCTGCTGCCCTTTTGCAGCAGATGATGCATCCAGCTAGTTGCTTCACCTGGCTAGTTGCCCCGGCCCTTTACTTTGGTTTTAGAATCCTTGTAGGTGAAGGGGTGGTTGCGGGATGAAGAATCTGCCCATTAGGGCTTTTTGCAGAGCTGTGTCAGCATTCACTAATTTAGAGCAAAGTATATAATCTGGGTGGCCTGGTTTCACTTCAAGTAGAACAGAGATGCTAAAAAAGAGGAAAAAGAAAGTGGATTGCTGGTACAGACAGAGCCCCCCAACCTCTGTGACAAGTGTGATTTGCATACTGCGAGTAGCCGGCCTGCACGCTCAAGTCTGTATGACTTCTGTCCTTATTTGGACTCTATTAAAAATACCCTCACTTAAAAAAAAGAAAATAAAATGAACTTATCCCATGAAAAATAGGTTCTGGGGAAAACGAACGCAGTCATCAAAATGTAGTTTGTTCGTAGTAGAACTTGCATCAAACCAATTATTGTGTCCCTACAGTAATTATAGTAGCATTTTTTTTGAAACCTGGATAATTTGGTCAAGGTAGGTGTCTTTTCTGTCAATGAAATCTTATGTAATTGCTCAAACTCCAGATACTTTTTTTTTTTTTTTAATTTTTATTTTCTGAAGACAGAGTCTTGCTTTGTTGCCGAGGCTGGAGTGCAGTGGTTTGATCTTGGCTCACTGTAGCCTCCACTTCCTGGGCCCAAGCAGTCCTCCCACCTCAGCCTCCCAAGTAGCTGGGACTACAAGTGTGTACTACCATGCCTCACCGTTTTTTTGTTTATTTTTTATTTATTTATTTTTTGTAGACATGGGGTCTCGCTCGCTATGTTGCCTGGGCTGGTCTTGACCTCCTGGACTCAGGTGATCCACCTGCCTTGGCCTCCCAAAGTTCTGGGATTACAGGAGGTGTGAGCCACTGTGTCTGGCCTGTAAATATTTTTGACAATTCTTTGGTTTAATTAACTTTGAAGTCTCCCTGTCCACCTCCCTTTGCCCCCAAACTAAGGTAGGACCCTGGCATTGTTAAGGGTACTATGAGTAATTTTAAAAGAATGCTTTGTTGGCATTTTTTAGTCTTTTTTTTTTACTCAGTCTTTTAGGAAGAAAGGTAAAGATTTTAAAAGTTACTCTTTTGGAAAGCAGACTTCTGAGGTGGGTTATAGCTAAAGATGTGGTAGCAGAGACCAAGCCCAAAAAAAACAAACTGATGCTCCCTTTTCTGCTTTTCTTACCCTGATCATGCCCCTCTCCTCCCATCTCTTCCTTCTGTGGTCTGAAAGTAAGCTAAAGCTTGAATTCTGGAGTTTCATGTAAACAGCTGTGATCTTCTTTCCAGCATCCCCTGTCTTTGTTTTGATGGAATAGGGAACAGCACATCCTATGTGGATTATTTTAATAACAAATCTGTTCTTTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTGGCCCAGGCTGGAGTGCAGTTGTGTGATCTCGGTTCACTGAAACCTCTGCCTCCCTGGTTCAAGCGATTCTCCTGGCTCAGCCTCCCAAGTGGGTGGGATTACAGGTGCCCACCACCATGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACATATGTGAGCCACTGCACCCGGCCCACAAATCGGTTCTTGAACAAGTGGTCAGTTGTCTTTCTGTTTGAGGTTGAGGCCAGGGAGAAGGGAAGAAGTAATAGTAGGATGGGTGTGGGGCAGAGTCGGGGGCACAGAGAATGGTCAGGCAACAGGGATGAGGAGAAGCAGTGGCCGGGCAGCAGGGGACTCAGTTAGTGAGGACCTGGCTCATCCATTCTTAGAAAGAGTGGTGATCTCAGGGAGCTAGCATTGTCTCATAAGAACAAGTAAAGCCAGCCTACCCTCATTTTTTTTTATGACAGGGTTATGAGATTGGTAGATTAAAAGAAGATGTAGATGTGGTTTAGTATATTCAGATTTTAGCAAATTATTTGACCAAGAGTTTCAGGAAACTAGAATCTTAACCTTATGCTTTGTTCTTAGAACGATACTGGCATGTAGAAGTAATTCAGTAAGTGCTCGTTGTTGCATGAATAAATAAAATAATATGTAAATGGTGAGGTGACTAGCCACTGGAGGTATCCAGCCAGAGACTGGGAGAGTCATTTGGTTGGATGGCATAGCGAGAATACTAATCTAGGAAGCGACTGGACTGGTTTCTCCCAACCCCAGCTATCTGTGTTCCTTCCTCATGAGGAAGCTGTTCTGAAAAGCTCTGTTTTAACCTTTGGCAATGCAGCCGTAACCTTGAGTTTGAGAAGCACTGCTCTGAAATCCTGTCTTCCATTAGCTTTGGAGCCAGCATCCTTCTTTACCATGAGAGAGAAGGCAGAGGGGCAGCACAGACGTGAGTTTCTGGGCAGTCGATCTCAGTCTTTATGTGGGCTGCCTAATGACCACTCGTTGGATTTTTTGTGGTGTTTTTCTCTGGTCTATGCACAGCAGAGGGCAAGGCTGGGGGAGACAAGGTTTTTATAAGTCACTATCTCAAAAACAAGTGGAAGCGAGTTTCTGGCTCATCTGCCTTACTACCTGGCCCCGATCCAGAGCTATTTATGAGCATGGCTGGGCCGTGAAGCTGCATGCCCTGGCAATGCCCGGTGGATGGGCTGTCCCACACCCTAATTGTGCTGGAATGGAACCCACAAAGACATCTCACTTTCACGACTGCACTTTCCAGGATGGCTGGCCTGGATCTTCTGCTTGCAGGCCTGTGCGTGCTTCTCCTTCCCCTTGAAGCTCCCCTTAAAGCCCTCAAAACTGTGCTTCACTGAAGGAACCAGGGCGAAAAAGGGCTGCATAAGATGAGACTCTGGGCTACTGTTTTTATTTTTTTGTTGTTTTTTTGTTGTTTTTTTTTTTGGGATGGAGTCTCCCTCTTGTCACCCAGGCTGGAGTACAGTGGCACGATCTCAACTCACTGCAACTTCCGCCTCCTGGGCTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGTTGGGATTATAGGCACCCGCCACCACACCCAGCTAATTTTTGCATGTTTACTAAAGACAGGGTTTCACCATGTTAGCCAGACTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCCCTCCCCTCGGCCTCCCAAAATGTTGGGATTACAGGTGTGAGCCACTGCCCCCGGCCCCTGGGCTACTCTTAAAGGCCGTCACATTAGGCAGTGGTGTTGATTTTTAGCCTAGGGTACCCTTCTGAAGATGTGCAGTGGCTGATCTATCAGCTGCCTCTCCACTTCCAGATCCCTTAGGTGTTTCCTAGGGACAAAAAAGTGAGCCAATACCAAATAAAAATCATGGCAAAGAGATTTTCATGGTAGGAACCATTGCTCTTAGAGTTGCTAATTAGCAGGGCAAGATAAGCATGTGCAGCAGGGCTGTGGCTGAGCAGTCTGTGGGAGGGGGTGTCCTGGCCAACAGCAGAAGAATCTGCTGGAATTGTTGGCGGTGTGTGTATGAGTGGGGTCGTGAAGCGTGAAGTGTGCAGGCATGGTGGTGAGGCACACAAGTGTAACAACCTGCTCCAAGTGTCAGATTTAGAGGAGCCACATAGAGTTTCAGATAAGGCAGAGGGCTTTCCCTATGTGAATGCAGCTTGAGGTTGTCCACAGGGGAGGTACTTGGCTGGTCTGACTTGGAGGTTCTACCCAGTGGTTCTTGTTGGTTCAGTGGAGGAGGAAGTGACTCTTGACCTCCTAATGTGCAGAGGCCGGTTATACAGGGAGCTCTGGAATAAGCAGACTTCTCAGGGACAGTTCTGGACTGGGTTTGGAGTAGGGCACAAGAAAGGGATAGGGCAGCAGATTTTAATGACCCCAATGTATTTTGTGGATGAAATCAACACAAGAGTATCAGAAGCACTCTGAAGGAAAAACAGATGTACAGTCTGGTGAAGAAAGGAGGGGCAGACTGGTCCCATTGCCTTGATAAAGGGCTTGGATGCTGTGCAGTGCGTGTGGGAACTGGACTCTTTTTAAAACACTGCCCTCGTCGGACGGCTCCCAGGGCCTCTGTCTGGGCAGCAGGAGTGGAAGACACTGCAAAGGAGGTGACTTGCCATACTTTAGGGCCAGCTGTTTTCTGGGGTCCAGGTTAGGGTGAGCTTTTTGCCTACATTCTGGAATCATCATGGAGAGGGGTTTCTCAATGCAATTGGTGTAGTTCCCCGCCTAACAGAATCACCCCATTGTTCTCACCGCTTTTTGGGAATCAGGGCAGCCAGTGCAGGTTGGCAGTGTAGGACCTCAGTGTGTCTTGTTTACTGAAGGTACACGTGTTGTTTTGAAATGCAGGTGAAGCCATATAATGTCTACATCACAGTTGCTTACCCACCAGACACAGACACACCTGGCTTTGCCGAAGAAAACAGAACAAAGGTCAGTATCCTACATGTCCCAATTTGAACCTCTAATGTTTACTGCTTTTCTGATTTTCTTTCTACTCTTCAGCTCACACTCGTTTTCACCAATCAACAATGTTTGTTGGGTAGAGTGCCTAGCTGGTTTCTGATGACCTTGAGATTCTCCAGGCAAATATTCCTTCTTTCCTTCCTCTTTTCCCTCACTTTATTTTCTTAAAGTTTAAATTTCTACCAGATTTTTTCTCTATAGAGACAGGGCCTCACTCTGCCATCCAGGCTGGAGTGCAGTGGTACAATCGTGGCTAACTGCATCCTCAAACTCTCAGGCTCAAGCAATCCTCCTGCCTCAGCCACCTGAGTAGCTGGGCCTACAGGCATGTGCCACCACACCTAGCTAATTTTTAATTTTTTTGTAGAGATGGAGTCTCACTATGTCGCCCAGGCTGGTGTCAAACTCCTGGCCTCAAGTGATCCTCCCTCCTCAGCCTCCCAGGTGCTGAGATTATAGGCATGAGCCATTGTACCCAGCCATTTCCAGCACATTTTTATCAAAGAAGTATGTCACACAGTTTTAGAGTCCAATATCAATCCTTTGCCTCATCTCTCCCATTCCCAATTCCTACTCCCTAGAGGTAGCCATTTATTTTAACTAACATGTTTATACTGCTTTTTTTTTTTTTAAGATTTAGAAATTATTTATTGACTTTCTACCGTGGAAGATAAAATTTAAGACCAGGCCAGGCACAGTGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCTAGGCAAGAAGATCACTTGAGGCCAGGAGTTCAAGACCAGCCTGGGCAACATAACAAAACCCTGTCTCTACAAAAAATTTAAAAATTAGCCAGGCATGGTGGCACATGCTTGTAGTTCCAGCTACTCAGGAGGCTGAGGTGGGAGGATCATTTGAGCCAGGGAGGTTGAGGCTGCAGTGAGCCATGATTGTAGTACTGCATTTCGACCTGGGTGACAGAGCGAGAACCAATATCTAAAAAAAAAAAAAATTAAAATTAAAAATAAAAAAATAAAAATTTAAGGCCAGCCATGGTGTCTCACACCTGTAATCCCAGTACTTTGGGAGGCCATGGCAGGAGGATTGATTGAGCCCAGGAGTTCGAGACCAGCCTAGGCAACATAGCAAGACCCTTTCCCTACAAAAAAATAAGCAAAATTAGAATTGTTCCAGCTACTCAGGAGGCTAAGGTGGAAGGATAGTGTATTAGTCCGTTCTTGCATTACTATAAATAAATGCCTGAGATTGGGTAATTTACACGTAAAAGAGGTTTAATTTGCTCACAGTTCCACAGGCTGTACAGTCTGCTGCTTCTGGGGAGGCCTCAGGAAACTTACAGTCTTAGGTAAAGGGAAAGCAGGTACGTCTTACGTGGTCGGAGCAGGAGGAAGAGAGAGAGGGGAGGTGCCACACACTTTTAAACAACCAGATCTCGTGAGAACTCACTCAGTATCACGAGAATAGCAAGAGGGAAATCCACCCCCATGATCCAGTGACCTCCCACCAGGTCCCTCCTCCAACATTGGGGATTGTAGTTGGACCTGAGATTTGCATGGGGACACAGATCCGAACCATATCAGATAGTTTGAGCCTAGGACGTCGAGGCTGCAGTGAGCCAAGATTGCGCCACTGCACTCCAGCCTGGGCAACAGAGTAAGACCTTGTTTCAAAACAAAAACATTAAGACTCATATCTGTTCCCCATTCCCTGTGTACTCCTCCCATCTCTTTAGTTAAATCAGGTTTAGTGCTCATATTAATATTATGCACACTTGGACCATTCTATAGTGACATTTCCTTTCTTGCCTTTTCATTTGCTTAGCTTTGTAATTATCTATAACTAATTCAGTCCCAGATTCAAACAGAACTGAGATTCTCCTTTTGATCCATGTGAGCACATTGGACATTCTATTAGATTCATTCTTTTTTCCTCAGACATTTCTCCTGGGGTCGTCCCCGTTCCTGGTCTGTTCTAGTTCTGCCACCCAGCGGTGGTGTCAGGACTTGTCTTCACCTCACACTGCACGTTCCCTTCTCCCCTCCCTTTGACGGAGCCCATGACTCTCACTTTTTTGGTTTATCTGCTCATTTTGGTGGAGCTATAATATTTTCCACCAATTTTCTGAGAAAGGGCACATCAGAGGTAATATTGTTTTAGAAACAACATGTCTGAAAATGCCTTTATTTTTATTTTAACCTTTTTTTTTTTTTTTTTTGTGATAGAGTCTTGCTCTGTCACCCATGCTGGAGTGCAGTGGTGCAATGTTGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGAGATTCTCGTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGCGTGCCACCAAGCCCGGCTGATTTTTTGTATTTTTTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCCAACTCCTGGCCCACTCTGGCCTCCCAAAGTGCTGGGATTACAGGCATAAGCCACTGTGCCTGGCCATTTTTCTTTATTCTTATGTATTGTTTTGTTAAGTACAGATTTCTAGTTTGGAAATAATGTTTCCTCAGATTTCTGTGAGCATTTATTGATTTCCAGCTTCCAGAATTTCTGTGGAATCCAGTGCTATTTTGATTCCCAACCTTTTGTATAGAACCTGTTTTTCCATTTATTTTTGGAAACCTTGTGTCCCTTTTTATCCTTATTTAATGGATTTTGGCATGAAATCTTCTCATTTCATATGAGCCCTTTTATTTTATCAACTTTTGTTCTGGGACATTTTATTATATTACTCCTTTTATCACTTCTTTCTTCCCAAAGTATTTCAAGTGTTCATTCTCTCTGGAGCATTTATTATTCAGATTTTTGAACTTTCTGGACTGATCCTCTAATTTCCTTCTATTTTCTCTCTCTTTTTTTTTTTAATCTCTTGGGCCTTTTGTTCTCCCTTCTAGGTTTTTATTCGCTTTATCCTTAAACCTTTTTGTTGAAATCTTTATTTCTACTGGGTTACATAAAAATTACTTTAGATCTCTTTTCTCTGAATATTTAAAACAGTTTTTAAAAATAGCTTCTTGCCTTATTTCATGGATTTCATATTTTCTCTTATGTCTAAGGATATTCACTCTGGATGTTTAGCCTTGTTTTTTTGTTGCTGTTGTTTTGTTTGAAAATTTCTTCTATATCTTGTATTATTTATTTCCTCCTACTTTCTTTTTCTCTGTTGTTGTTTTTTCCGGCTTCCTGAAATGTCTGTTGATCCTTGATTGTCCATATTTAAGAGTGATGCACTAAAATGCCAATTGTAAATCTCTAGCTTCTCAGCTGTTTACTATAGGATGATCAGGAGGGGATGCAGCCACTTCATTAGAAGATTCTCATATGCCAGCATCTGCTCACTTTTCTCATGGTTTGATCAGTTTCCCTACTGAGGAATCATGTCTTCTTCTGCCTTTGGGAGAGTAAGACTTGCTGTCTGTGTTGTGGGAGGCAAGCAGGGCAGGAGGGCTGGGGAGCTCACCACCTACGTGCCAACTTTTGCTTAATTTTTCTGTTTCTACAAAGTGCCTTATAACTACTCTTAGTGGTGAGAATTAAGAATCTGGTTAGTAAATTGCTAATCTTTTGCCATCGTAGAGGAGATGACTTGGGGTCTGATGATTTGAGTCTCCATTGCACTTATCACAGCTTATAACAGAAGCTTCTCATAGCACTTAAAACAGACATATCTTTTATATAAAATGACTGCCAGTCATCCTGAGCTGAATATAAGCTTCACACTTTTTCAATGGAATATTCCCTTTGCCTTGACACATAGTAGTTGCTTTTTTGAGCAAATGAATAGGTGAAGCGGGAAGAAAGGAATTAATCAGAACTTACCACCTTGAACTGTGGCCAATTTTAGTTTTATATATTTTTTTCTCTTTTATACGAATACTTTGTAAATGTGAATCTCTGCAGCATAAAAATTGGCACTTAAACTCCCTAGACTGTATATTTGTAGAAAGATGTTTGTGATTTAGGTTTTTTCCCCCTATTCTTTTCTCTTTGGCTCTGCCTTTTTAAAAATTACTGCTATTTCAAAGAAGTAAATTTAAGCCAAATGTCCTGTCTTAGAATAAGCAGAGATCTTCTAAGCAGCTTTGCAACATTCGGTATGCAGTCTTTTAGTTTGAAGCCAGAGCTGACAAAGGGTGGTGATTTCCCTGTTAAGGTTTGATTCTGATGTTGATTAAGTTGGGGTTTTTTCAGTAAAATTTTGGGCAGACTTGTTGGGGGTAAATACAATTCTACATTGATGTGTGGGCCCTTTAGGGGGCGCCATAGTACTTTAGAATCTTATGTGTATTTAGTGTGGTTATGCCAGCCTGGGGGTCTGGAAGAATGAATCGTGGCTCCTTCAAAACAGCCTTTCTCTTAAGAAAGGTTCATAAGAAATACTTGATCTTTATGAAATACTTTACTTTCCTATTTTAAGAAAATATAATCTGGTTTTTATTTTCTTTAATTCCTTCAAGCTTACGTGGTAAAGTTTACAGTCTCATGCAGTTTAAGGCTTTTGTTTGACACTTCTACTTGAAATTATTTGACACTTCTAATTGAAACTAACTGAAATAATTTTTGAGCACACATATGCAAGACATCGCAAAGAAAAGCCAAAGATAAATAATTTCTTACAAAAAAGGCCCTGCCCACAAGAAACTTAGGAGGTAAAATGCAAATGCACAAGTAGCTATAATGTGTATTAAAACAGAAATGTTCACAGAAGAAAGAGAGAGGTTACTGCCAGTTAGGTATTTAGGGAAGGCTTTTTGAGTTAGGTAAGAGTTGAGATGGACCTTTTGAGGAAGAAAAGGCTAAGATTTGGGGTCTGCAGCTCCAGCCTGGTAACTAGCATGCAGCCCATCTAGGGACCACTCAGGGTTATCTCCTAAGTGGCTCCTTCTGTTTCAGTGTCCTGTGCATTTGCCTCCTCAGCAAGTCCTTTAAGAAGCATCTGCAGTTGTTGAATGGGGGCTGGGTTGCGACTGTCCCTGCCTTGGGCGCCAGGTTCATCCCCAGGGATCAGCCCTCTGCTGACCTGGGAATATGGTCAGAATGGAGTTGCTGGTCTTGGGAGCAGGCTTGCTCTGGACACAGGTCTAGCCTCTACAGAAAAGCACCATCATTCAGGTGTCCGCCCAGCACTGAGGAGTCAAAGGGGGTCTTTCTGAACTTGTATCCAGTGATGTGTTCTCACTCTAGCTTTGATGGTCCTCAGTGGAGCCAAGACTCCGTATGTTCTAAGAGAATGGCAAAGGCCTCCTTGTCTTGTGTTAGCTACTGGGTAGAATTTTACGTAGTAACTAGGTAGACACTGATTTAGAATCCAGATGGACCTTATTCTAGAAATAGGAATCTGCCCAAAGGTAGAAAATTGGAATTATTTGTAAATCAGGAGGCTGTAAGAATAATTTATTTTTAATGTAATGGGCAATCATGATATTGTTATGTACATGTTTTTCCACTTTTAGCCTTTGGAGACTCGACTTATTTCAGAGACCACATCTGTGTGCAAACCAGAACAGGTGGCCAAACAAATTGTTAAAGATGCCATAGTAAGTAAAATCCTTGTTTTCTGTACTATTTGTGTTTGTAGTACTATATTTCTGAAAAGATATTTGTCCAAGGACTTACTTCAAAACATCAATTATTAGAATTTTTTAGTCTGTCAGATTTGTCATATCTAATATTGGACTCAACTTTTCTTCTTTTAGACGCTTTATTGACTCCATATTAGTGAGTAGCCTCCTGAAAACTGATTGTATACCTTAATCTGAGGAACAGGTTTACTAGAAGGATGTCTGGAAACACCGGTTCTTTAAAAAGAAAATGAGACTTTCCTATGAGTGTAAACGATATATACTATGTCCCATATACACCTGGCTGCTTTCTCTCCCATTCCTGCTTCCCAGTATCATTTTCCCAAAAGTTAGCTAACGAGAAAGTGCCACCAGCCCCGTGGGCCTGTCCTCCTGTCTTCCCTGTTGATATGTTTTTTAATTCAGAATCAAAAATGGTATTTTAAGAAATGATGTGCTGTTTTGTAGAAGAACAACATATGTGCCTCATGCTTTTTGACAACATTTCTGTTAATGCGGAAAAATGCACATTTATGAGGGATGTCTGTAAACCACAGACCCACACTGAATTTGGAAAATCTATAGGACCATTGGAATGAGAGGTGTCAGCACATGGTGGACAGCCTTGAAGTGGCCTAAATGCTGTCACATTAGACTGAACTGAGCAGAATGAGAATAGTGAATTCTGTTGAAATATATACATGTGTGAAGAACTTTGTCCTGAGTGCATTAAAAGGCTCAGGAAGATGGCACAAGTGAGACTTTATTTTTCCTGCTTATCTCGGGTCAAAGCAAATGCATTTGGTGTTTTTTGTTGTTGTTGTTGTTTTGTTTGTTTGTTTGTTTTGAGACGGAGTTTTGCTCTTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAACCTCTGCCTCCTGGGTTTAAGTGATTCTCCTGCCTCGGCCTTCTGAGTAGCTGGGATTACAGGTGCTCACAACCACACCTGGCTAATTTTTTGTATTTGTAGTAGAAATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGATTTCGGGTAATCCGCACGCCTCAGCCTCTTGGCCAAAGTGCTGGGATTACAGGCGTGAGCTCCGTGCCCAGCCCATTCAGTGTTTCTAATGATGCTAAATAGCTCTTAGTATTTTGGCAGTATTCATTTAGTTTAGTGGTTTTCAAACTTTTCTTCTCTTGACCACTTTACATTCTTACAAATTGTCAACAACCCCAGAGAACTTTTGTTTATTTACATGGCTATATTTATTGATATTTGCCATATTTGAAATGGAAGCTGTTTGTAATATTTATTGATTCATTAAAAATAACAAAAATGGCTGGGCACAGTGACTCGTGCCTGTAATCCCAACACTTTGGGAGGCCAAGGCGGGCGGATCACCTGAAGTCAGGAGTTCAATACCAGCCTGACCAATATGATGAAACCCCGTCTCTACTAAAAATACAAAAATTAGTCGGGTGTGGTGACATGCGCCTGTAATCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCCAGGAGGTGGAGACTGCAGTGAGCTGAGATTGAGCCATTGTGCTCCAGCCTGGGCAACAAGAGCAAAACTCCATATATATATATATATATATATATTCACATATATATATATATAAAGTCACATATATATATATATAAAGTCACATATATATAAAGTGACTTTTTTTAAACAAAATTTACTACTTTTCAAAACAAAAGTTCAGTGAGGACGGTGGCATTGGTTCACATTTTCACCAGTTGCTTTAAGGTCTGCATTAACAGCTGGATTCAAATAGCTGCTTCTGCATTCCATCTGTTGTAATAATGTTGTTTTGATGGAAGGATATACAGAAAATCTGGCCTGAGACAGATACGGAGTTGGGAAAGGGAAGACTATTTTACTAGGCTTTTCAGATAATTATGGACATTCTTTTTTGATATCAAACCCAAACTCAACAAATGGTAGTTTCTTAAAGGTTAGTTGCAGTATAGAATTGGAAACTACATCAATGAATGTTTTGTTCTCTGTTACATTAAATTCCATTGGTCCGTCTTGTACTTTGAATGGATCTTTTAACCATTCATGATTTCGTAACATTATGCATTAGTCATTTGGAAAATATGGGTTGACTGAGTGATCAGAAAAATCGCTTTCATCAGTATTACTGCTGATCTTATCATAAAAGTATGCAGCTGACAGTCTCGTGATGGTGGATACTAGTTTTTCCAAATCTTAATTTTTTCTTGAAGGCTCAGATTTCACATTGATGACACGTGGCCAGTTGTTTTTCCTGAAGTGACACACTTGCTTGCTTCGCTTTCTGCACATCTGCCACATACCTAAGTCTGAATTACTATAGATTTCCTGTCAATGGTCTTTCATATAAAAATTATGCTCTCCAGCCAGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTTGGAGGCCGAGGCGGCTGGATCGCTTGAGCTCAGGGGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTACCCGGGTGTGGTGGTGCATGCCTGTAATCCCAGCTACTTGGGAGTCTGAGGCAGGAGAATCACTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCAGAGATCACACCACTGCATTCCAGCCTGGGCCACAGAGTGAGATTCTGTCGAAAATAAATAAATAAACAATACAAATGATGCTCCATGAAAGAAGTGGCAGTTTAGCCCTTGACTTCAGGAGCTGCACAAGGACTTTTGTTCCAGGCAGTTGTCCCGCCCTGGAATGCAGTGCTGCGGAAGCGCGTTGCGCGCATTCTCATTTGTCACACAGAGTATTAAGAAGACATGTCCTCGAGGGTTGCCATTGAACAAAATGATGAATTTTCCTGCTTTATCAAGAGGATTTTAAAGCAAAACTGACACTTTGATTTTTAAAAGAATTTTAGAACTTGTATTTTCTTTGTGTATTATTTATTACTGCGAGTGCGTGTGGTAGTAGAGGTGACAATGACTCCTAGTACAGTTTGGCAAGAACCCCGTGGTTCTTGCCCATGTCTCTGCAGTTTTGCAGAGGCAAAACTGTATTTTCCATACAACACACTGTGGAAAAGACAATGAATGTCTTAGTGTTATTAGGACAATCATTTGTCCTTGGGGGCCCGCAGGGGTCCGTGGACTCACTTGTTGAGAACTGCCATCTGCCAAGGCCGTGCGTCCATTTCTGAGTGCTGATCAATGCTTTGTGACCATTTTATCTCACTTAAAGTGAACGAGCACACTCCACTGTTTCTGATGTGTCCGACTGATTTCTGTCCACATTACTAGGATTCCCTCTTTCTCTTCTTTTTCTTCTCTTTTAGCAAGGAAATTTCAACAGTTCCCTTGGCTCAGATGGGTACATGCTCTCGGCCCTGACCTGTGGGATGGCTCCAGTAACTTCTATTACTGAGGGGCTCCAGCAGGTAAGCTCTGCCTAGGCTAGCAATCAGACAGGCCGATGGACAAGAGAAAAACTGCCTTTCATCAAACCTTGATGAGAACAGGTTAAGGGAAAACTAAGTAACTTTATTTGACAATGTATTTTTATGGAGCTATCAACTTTTCCTCTTCCTCCACCACGAATGAGTAAATAGGTTAAAGATATAACTTCAGGAATTTAGAATGGCAAGAAGTCTTCAGTGCCGGGCCTTGCAGATAGAGAAATAAAACACCGTATCTGCTGTTGAGGTGTTAACCTGGATTTTCACCTAAGAACCACTGCTCCAATGTGTTTTGAAAATGGAATACTCCTCTAGAGTAAGGGGTAGCCTTGCTTAAAAAGTACTGGGATATTAGACTAGAAAACCTTTTCTAGGTGAATCAGGTCACACACAGCTAAATTTAGTGAGACACGAATCATGGATTAAACAGTTGCTTCGCTTATAGAATGTATTATTTTGTCCAAGATACACAGTGTTTCATTGGTGTGCTAGGCACTGTACTTGCTCATGGGGAATCAGATGGAAGGCGACCTCTCCAGCTTCAGGGGCATACAGTCAAGTGGAATGCACTGACCAAAAAGGTGATAGTAGTCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGAGAGGCTGAGGTGGGTAGATCACTTGAGATCAGGAGTTCGAGACCAGCCTGGCCAAGATGGTGAAACTGTTTCTACTAAAAACACAAAAATTAGCTGGGCATGGTGGCGGACGCCTGTAATCCCAGCTACTCGGGAGGTTGAGGTAGGAGAATTACTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCGAGATCAAGCCACTGCACTCCAGCCTAGGCTACAAGGGCAAAACTCTGTCTCAAAAAAAAAAAAAAAGATAGTAGTGCAGTGTAATGAAGTAGGGGTTACAATAGAGGGAATGCTCTGGAAAGACAAAGCCATGGGATAGTTGTTAACAAGTACTAAATTCTGTGCAGTCAACCACATTCAGACTTATATAAATGACTTAGTTGTTGGTTTTCTTCAGGGTCTTTCCCAAGCCCTCTTTTCTTTTCATTCTGTAATGTACCTACTGTCTTTGCCATTCTCTTAGAGGTTGACACTGTGTTAGATGTAAGCTCTTTGAGGACCAGGCCCACACCTCTTGTTTGCCGTTGTACCCCTAACAGCCAGCGCCTGGCACTTAGTAGGAACTCCAGAATCCCTGAGCTGAACAAATGCATGAATTCTTTTATGTTTTAATTTTTGGGCTGGCATGGTGGCTCACACCTGGCGTGTTGTCCTGGACTCCCCTGCTTCTGTCCCTCACGTCAGAGATCATTGTCATCCTTGTCACTCAGTTCTTCACATTCTTCCATTCTCTGCAATTCTGGCAGTGCTTCTGGAGCCCAGGCCTGGGTTGCCGCAGCAGGCCCCCTGCTTGAGTTACACACTTTTTGAGCCAGAGGTTGTAAACGATTCCCATGGGCCTGTAAAGCAGTTTTGTTGGGTCCATCTGGTGTGAGTGTGTGTGTTTAAGATTTTAAAATAGTTTTAAAATTAGGTTTTATATAAAAGGTCCAGATTTCAGACTTTTCTTGGAAAATCAGAAGGTTTAGCTGCACAGAGTCTGCATTCTTACCTGGCAGTCATCAGCAAGCACAGGTGGCAGCTGCTCCTGAGGGAGGAGCACAGTCCCTGCAACCACTATGGTCTGCAACCCCCTGCTCAGGCCCCCTGGATGCGTTTGAGTGTACCCTCACATTTTCCACACCAGTTGTTTCTAAACTGCAACTATACATTGCATGAAAACATTCAATGACTCCTTGATACCATCAGGATAAAGCTTTAAAAATTCCATTGCACCTGAGTATGGTGGCTCATGCCTATAATCTCAGCACTTTGGGAGGCCAAGTCAGGAGGATCGCTTGAGCTCAGGAGTTTGAGATCAGCCTGGGCAACATAGTGAGACCCTGTCTCTACAAAAAAATGTAAAAGAAAAGAAAGCCAGGCGTGGTGGTGTGTACCTGTATTCCTAGCAACTGGGAGACTTCTGCTTGAGTCCAGAAGTCTGAAGCTACAGTGAGCTGTGATCATACTCCTGCACTCCAGCCTGGGTGACAGAGCAAGACCCTGTCTCTAAAAAGGATTTAAAAATTAAAAAAATTTCCATCGCATGCCATAAACCACCTGATCTCCTACCCCACGTACCTTTCCAGGCTCTTTTTTTTCTTTCTTTCTTTACCCATCTTCTTCTTTTTGGAATCTTCTCTGTGTCCTGCCAACTTCTAATCCTTCAGGTCTCACCTTAAATATTGTTTTTTCCGGAAGATCCAAGGACTGGCTTCAGTGCTCTGAGGGTGTAGGGAAAAAAACAAAGGGATTTTTCTATTCTCTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCACCCAGGCTGAAGTGCAGTGGCACGATCTCAGCTCACTGCACGCTCTGCCTCCTGGGTTCACACCATTCTCCTGCCTCAGCCTCCCCAGCAGCTTGGACTACAGGCGCACACCGCCACACGCGGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCGTGTTAGCCAGGATGGTCTCAATCTCCTGACCTCGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCTGATTTTTCCATTCTCTTATGCACGGGGACTCATGCCTATGGTCCCAGCTGCTTGGGAGGATGAGGCAGCAGAATCCTTTGAGTTTGGGAGGTCAAAGCTATAGTGAGCCGCGTTCATGCCACTGCACTCCATCCTGAGCAACAGGATATCAGTAATCACGGGTCTCAACCCTGAGGCAGTAGTTTCAATTTTACTTGTCTTTCCAGCCTGAGAATAAGCTCATTGAGGGCAGGGACTGTGTCTCTCACCACAGTGTTCACAGCACCTAGTATAGGGTCTCGCTTTCATGCTCAGAACATAAATTGCAAACCAAAAAAGCCTTGATTGTAGTTTGGCTATTTGAGATGCTGCACTGGGTCTTTTTAAAGCTATTATAACCCTAAGACTGCAAGCAATATATATTTTATTCTGCTTATGGTTTGAATTTATTAATTGGACAAATATTTTGTTATGTATCTGGGCTGTCCAGCGGTGCAGAGCACACACATTCTGTTCTCACAGCTTACTGACATTTACAGAGTTTTCATTATATTCATCCTTAGAGCAGACTAGAAGATTTGTCTTAGAAACTGTTTGTTAGAGACCTAGGTACCTTGAAATAGTCTTGTACCGTTGGATGCACTAAAAGCTCTCTCTTTATCTTGCAGGTGGTCACCATGGGCCTTTTCCGCACTATTGCTTTGTTTTACCTTGGAAGTTTTGACAGCATAGTTCGTCGCTGCATGATGCAGAGAGAAAAATCTGAAAATGCAGACAAAACTGCCTAATCTTCTTACCCCTTGGAAGAAGACTGTTTCCAAATAATTTGAACAGCTTGCTGCTAAATGGGACCCAATTTTTGGCCTATAGACACTTATGTATTGTTTTCGAATACGTCAGATTGGACCAGTGCTCTTCAGGAATGTGGCTGCAAGCAAGGGGCTAGAAGTTCACCTCCTGACAGTATTATTAATACTATGCAAATATGGAATAGGAGACCATTTGATTTTCTAGGCTTTGTGGTAGAGAGGTGAAGGTATGAGAATTAATAGCGTGTGAACAAAGTAAAGAACAGGATTCCAGAATGATCATTAAATTTGTTTCTATTTATTCTTTTTTGCCCCCCTAGAGATTAAGTCCAGAAATGTACTTTCTGGCACATAAAGAAATCTTGAGGACTTTGTTTAAACCTTCCATAAAAAAACAATTTTCGGTTTCTCGGGTTCTCTCTCTCTCTCTCTCTGTCTCTCTGTCTCTCTGTCTCTCTGTCTCTCTGTCTCTCTGTCTCTCTCTCTCTCTCTCTTTCTTTCTTTGTGTATTTTATTCAAGATGAGTTGGACCCATTGCCAGTGAGTCTGAATGTCACTGACAGCCCTGTGTTGTGCTCAGGACTCACTCTGCTGCTGGTGGAAACTCATGGCTTCTCTCTCTCTTTGATCCCATAAAGCTACGAGGGGGACGGGAGAGGGCAGTGCAATGGGAAGTAAAGAGATATTTTCCAGTAGGAAAAGCAATGCTTTCTTGTCTTTAGACTCAAATGCTTAGGGAACGTTTCATTTCTCATTCATGGGGAAAGGCAGCCTCCTTAAATGTTTTCTGAAGAGCGGTAAAATCTAGAAGCTTAAGAATTTACAGTTCCTTCAATAACCATGATGACCTGAAGTTCACCTATCCCATTTTAGCATCTACTTGTTTTTCCCATCTCTTCCTTTCCAATTTTGCTTATACTGCTGTAATATTTTTGTAAAAAAAAAAAAAAAGGAAAAAAAAGACCAGCTAAAATTTTCGACTTGACTTTTTAACTTAACTCATGAATTAATTAAAGCAAATGAAAAAATTAAAAAGTGTGACTTTTTCTCGGAGCATATATGTAGCTTTTAGGAAAGGCTGATGATGGTATAAAGTTTGCTCATTAAGAAAAAAAGACAAGGCTGATTTTGAAGAGAGTTGCTTTTGAAATAAAATGATCACCTGTTCTTTATGTGACTCTCCCACTGAACCTGCAGACATTATTTTTATACCACATGCTAAGGAAGCCCACTCATCTAACTCTGTAGCCCTGHUMAN mRNA SEQUENCE:hR22-022.1 (Seq ID No: 7)GGCTCCTCCTCTTCCCCTCCGCCGCGGCCCGCCCCGGCCCGCAAACCCAAACACTCCAGGCGCCCGCCCGCCGCGCGTGATTCTCGCCTCGCCGCAGCCCAGCCCTGCGCGCCTTGCCCGGCGGCCCCCGCCCGGCCGCTCCGGGCCCCTGGCCCCGCGGAGCGATGCTGCTGCTGGCTGCCGCCTTCCTCGTGGCCTTCGTGCTGCTGCTGTACATGGTGTCTCCGCTCATCAGCCCCAAGCCCCTCGCCCTGCCCGGGGCGCATGTGGTGGTTACAGGAGGTTCCAGTGGCATCGGGAAGTGCATTGCTATCGAGTGCTATAAACAAGGAGCTTTTATAACTCTGGTTGCACGAAATGAGGATAAGCTGCTGCAGGCAAAGAAAGAAATTGAAATGCACTCTATTAATGACAAACAGGTGGTACTTTGCATATCAGTTGATGTATCTCAAGACTATAACCAAGTAGAGAATGTCATAAAACAAGCACAGGAGAAACTGGGTCCAGTGGACATGCTGGTAAATTGTGCAGGAATGGCAGTGTCAGGAAAATTTGAAGATCTTGAAGTTAGTACCTTTGAAAGGTTAATGAGCATCAATTACCTGGGCAGCGTGTACCCCAGCCGGGCCGTGATCACCACCATGAAGGAGCGCCGGGTGGGCAGGATCGTGTTTGTGTCCTCCCAGGCAGGACAGTTGGGATTATTCGGTTTCACAGCCTACTCTGCATCCAAGTTTGCCATAAGGGGATTGGCAGAAGCTTTGCAGATGGAGGTGAAGCCATATAATGTCTACATCACAGTTGCTTACCCACCAGACACAGACACACCTGGCTTTGCCGAAGAAAACAGAACAAAGCCTTTGGAGACTCGACTTATTTCAGAGACCACATCTGTGTGCAAACCAGAACAGGTGGCCAAACAAATTGTTAAAGATGCCATACAAGGAAATTTCAACAGTTCCCTTGGCTCAGATGGGTACATGCTCTCGGCCCTGACCTGTGGGATGGCTCCAGTAACTTCTATTACTGAGGGGCTCCAGCAGGTGGTCACCATGGGCCTTTTCCGCACTATTGCTTTGTTTTACCTTGGAAGTTTTGACAGCATAGTTCGTCGCTGCATGATGCAGAGAGAAAAATCTGAAAATGCAGACAAAACTGCCTAATCTTCTTACCCCTTGGAAGAAGACTGTTTCCAAATAATTTGAACAGCTTGCTGCTAAATGGGACCCAATTTTTGGCCTATAGACACTTATGTATTGTTTTCGAATACGTCAGATTGGACCAGTGCTCTTCAGGAATGTGGCTGCAAGCAAGGGGCTAGAAGTTCACCTCCTGACAGTATTATTAATACTATGCAAATATGGAATAGGAGACCATTTGATTTTCTAGGCTTTGTGGTAGAGAGGTGAAGGTATGAGAATTAATAGCGTGTGAACAAAGTAAAGAACAGGATTCCAGAATGATCATTAAATTTGTTTCTATTTATTCTTTTTTGCCCCCCTAGAGATTAAGTCCAGAAATGTACTTTCTGGCACATAAAGAAATCTTGAGGACTTTGTTTAAACCTTCCATAAAAAAACAATTTTCGGTTTCTCGGTCTCTGTCTCTCTGTCTCTCTGTCTCTCTGTCTCTCTGTCTCTCTGTCTCTCTCTCTCTCTCTCTTTCTTTCTTTGTGTATTTTATTCAAGATGAGTTGGACCCATTGCCAGTGAGTCTGAATGTCACTGACAGCCCTGTGTTGTGCTCAGGACTCACTCTGCTGCTGGTGGAAACTCATGGCTTCTCTCTCTCTTTGATCCCATAAAGCTACGACGGGGACGGGAGAGGGCAGTGCAATGGGAAGTAAAGAGATATTTTCCAGTAGGAAAAGCAATGCTTTCTTGTCTTTAGACTCAAATGCTTAGGGAACGTTTCATTTCTCATTCATGGGGAAAGGCAGCCTCCTTAAATGTTTTCTGAAGAGCGGTAAAATCTAGAAGCTTAAGAATTTACAGTTCCTTCAATAACCATGATGACCTGAAGTTCACCTATCCCATTTTAGCATCTACTTGTTTTTCCCATCTCTTCCTTTCCAATTTTGCTTATACTGCTGTAATATTTTTGTAAAAAAAAAAAAAAAGGAAAAAAAAGACCAGCTAAAATTTTCGACTTGACTTTTTAACTTAACTCATGAATTAATTAAAGCAAATGAAAAAATTAAAAAGTGTGACTTTTTCTCGGAGCATATATGTAGCTTTTAGGAAAGGCTGATGATGGTATAAAGTTTGCTCATTAAGAAAAAAAGACAAGGCTGATTTTGAAGAGAGTTGCTTTTGAAATAAAATGATCACCTGTTCTTTATGTGACTCTCCCACTGAACCTGCAGACATTATTTTTATACCACATGCTAAGGAAGCCCACTCATCTAACTCTGTAGCCCTGHUMAN mRNA SEQUENCE:hR22-022.2 (Seq ID No: 9)GGCTCCTCCTCTTCCCCTCCGCCGCGGCCCGCCCCGGCCCGCAAACCCAAACACTCCAGGCGCCCGCCCGCCGCGCGTGATTCTCGCCTCGCCGCAGCCCAGCCCTGCGCGCCTTGCCCGGCGGCCCCCGCCCGGCCGCTCCGGGCCCCTGGCCCCGCGGAGCGATGCTGCTGCTGGCTGCCGCCTTCCTCGTGGCCTTCGTGCTGCTGCTGTACATGGTGTCTCCGCTCATCAGCCCCAAGCCCCTCGCCCTGCCCGGGGCGCATGTGGTGGTTACAGGAGGTTCCAGTGGCATCGGGAAGTGCATTGCTATCGAGTGCTATAAACAAGGAGCTTTTATAACTCTGGTTGCACGAAATGAGGATAAGCTGCTGCAGGCAAAGAAAGAAATTGAAATGCACTCTATTAATGACAAACAGGTGGTACTTTGCATATCAGTTGATGTATCTCAAGACTATAACCAAGTAGAGAATGTCATAAAACAAGCACAGGAGAAACTGGGTCCAGTGGACATGCTGGTAAATTGTGCAGGAATGGCAGTGTCAGGAAAATTTGAAGATCTTGAAGTTAGTACCTTTGAAAGGTTAATGAGCATCAATTACCTGGGCAGCGTGTACCCCAGCCGGGCCGTGATCACCACCATGAAGGAGCGCCGGGTGGGCAGGATCGTGTTTGTGTCCTCCCAGGCACGACAGTTGGGATTATTCGGTTTCACAGCCTACTCTGCATCCAAGTTTGCCATAAGGGGATTGGCAGAAGCTTTGCAGATGGAGGTGAAGCCATATAATGTCTACATCACAGTTGCTTACCCACCAGACACAGACACACCTGGCTTTGCCGAAGAAAACAGAACAAAGCCTTTGGAGACTCGACTTATTTCAGAGACCACATCTGTGTGCAAACCAGAACACGTGGCCAAACAAATTGTTAAAGATGCCATACAAGGAAATTTCAACAGTTCCCTTGGCTCAGATGGGTACATGCTCTCGGCCCTGACCTGTGGGATGGCTCCAGTAACTTCTATTACTGAGGGGCTCCAGCAGGTGGTCACCATGGGCCTTTTCCGCACTATTGCTTTGTTTTACCTTGGAAGTTTTGACAGCATAGTTCGTCGCTGCATGATGCAGAGAGAAAAATCTGAAAATGCAGACAAAACTGCCTAATCTTCTTACCCCTTGGAAGAACACTGTTTCCAAATAATTTGAACAGCTTGCTGCTAAATGGGACCCAATTTTTGGCCTATAGACACTTATGTATTGTTTTCGAATACGTCAGATTGGACCAGTGCTCTTCAGGAATGTGGCTGCAAGCAAGGGGCTAGAAGTTCACCTCCTGACAGTATTATTAATACTATGCAAATATGGAATAGGAGACCATTTGATTTTCTAGGCTTTGTGGTAGAGAGGTGAACGTATGAGAATTAATAGCGTGTGAACAAAGTAAAGAACAGGATTCCAGAATGATCATTAAATTTGTTTCTATTTATTCTTTTTTGCCCCCCTAGAGATTAAGTCCAGAAATGTACTTTCTGGCACATAAAGAAATCTTGAGGACTTTGTTTAAACCTTCCATAAAAAAACAATTTTCGGTTTCTCGGGTTCTCTCTCTCTCTCTCTCTGTCTCTCTGTCTCTCTGTCTCTCTGTCTCTCTGTCTCTCTGTCTCTCTCTCTCTCTCTCTTTCTTTCTTTGTGTATTTTATTCAAGATGAGTTGGACCCATTGCCAGTGAGTCTGAATGTCACTGACAGCCCTGTGTTGTGCTCAGGACTCACTCTGCTGCTGGTGGAAACTCATGGCTTCTCTCTCTCTTTGATCCCATAAAGCTACGAGGGGGACGGGAGAGGGCAGTGCAATGGGAAGTAAAGAGATATTTTCCAGTAGGAAAAGCAATGCTTTCTTGTCTTTAGACTCAAATGCTTAGGGAACGTTTCATTTCTCATTCATGGGGAAAGGCAGCCTCCTTAAATGTTTTCTGAAGAGCGGTAAAATCTAGAAGCTTAAGAATTTACAGTTCCTTCAATAACCATGATGACCTGAAGTTCACCTATCCCATTTTAGCATCTACTTGTTTTTCCCATCTCTTCCTTTCCAATTTTGCTTATACTGCTGTAATATTTTTGTAAAAAAAAAAAAAAAGGAAAAAAAAGACCAGCTAAAATTTTCGACTTGACTTTTTAACTTAACTCATGAATTAATTAAAGCAAATGAAAAAATTAAAAAGTGTGACTTTTTCTCGGAGCATATATGTAGCTTTTAGGAAAGGCTGATGATGGTATAAAGTTTGCTCATTAAGAAAAAAAGACAAGGCTGATTTTGAAGAGAGTTGCTTTTGAAATAAAATGATCACCTGTTCTTTATGTGACTCTCCCACTGAACCTGCAGACATTATTTTTATACCACATGCTAAGGAAGCCCACTCATCTAACTCTGTAGCCCTGHUMAN PROTEIN SEQUENCE:hP22-022.2 (Seq ID No: 10)MLLLAAAFLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITVAYPPDTDTPGFAEENRTKPLETRLISETTSVCKPEQVAKQIVKDAIQGNFNSSLGSDGYMLSALTCGMAPVTSITEGLQQVVTMGLFRTIALFYLGSFDSIVRRCMMQREKSENADKTA*










TABLE 2










MOUSE GENOMIC SEQUENCE:mD27-007 (Seq ID No: 11)



CAAGTTACACTCAACTGTTTTAGAAGAGCAGTTCCCCAGATTTCTCCTTGGAGCTGTGAGTGACTACCATTGCGAGCAAGAGCAAGA


GGAAAGCACTACCTGTGAGCAGATGTCTGGTTCATTCTCACCCTGTGTGGTGTTCACACAGATGTGGCTGACTCTACTGGTTGTGAG


TGAGTAGATGGCTCAATATGGGGATAGAGTGGGTCGGACAGCATCTCTCTCCACTACAGGCCTGGTACTCTCTTAAGTTTTAGCTCC


TCAGTTTCCCCGTGTGAGGCTGTGTTCCCCGACTTTACTGTACAGCTTAGAATTTCCTCTCCTGAGCCCAAAGAAAGTAGTCACAGG


TTGAAAAAAAAAAATCCTTCAATGGACAGAGGAAGAAACGGTAGCAATGGCACTAGAGTTTCGCTTGCTTTCTTTTCTTTAACAAAT


ACTTTATGAAGCACAGAAAGTAAATCACACTTGCTTGTTCAAACTCTTTTATTCAAATGAGAACTATATTTTAATCCCGTGTAGACA


GGCTAGACCCTGGCCTTGTGCCTAAGATGATAGCTCCTTCTGCACATTAGCGAGAGCCATGAGCAGGACTGGGCGCCTTAAGTACAA


GAGGGGAAATCAGGAAGGAGAGGTACCTACAGCAGTGGCTATGTCACTGCCCATGGATATGCATGCATTTCTGTCAGTTCATGCCTA


CAAAGGGTTTGCTTCTTACTAAATTTTAAATGGAATTAAATGTGGGTTCATCTATTTTTAAAAAGTTCTTAGGCCGGGCAGTGGTGG


CGCATGCCTTTAATCCTAGCACTTGGGAGGCAGAGGCAGGAGGATTTCTGAGTTCGAGGCCAGCCTGGTCTACAGAGTGAGTTCCAG


CACAGCCAGGGCTATACAGAGAAACCCTGTCTTGAAAAACCAAAAAACAAAAACCAAACAAACAAACAAACAAAAGGTTCTTAGCGC


CATCTATGCACAGCATTGTATGCAATGCTGAGGACGGAGGGTTGTTTTGTGCCCACAAGGGAAAACACCAAAAAAAAAAAAAAAAAA


GCTCTCAGCAAAGCCAGTGCACAAGAAACAGCTGGGAAACACAATTCTAGTAAAATAAAATCCCAGTGGATGGCACAGACAGATAAC


CATAACCATCTACATACCAGTCAGGTGATCAGACTAAGCAACAGATAGGGCAAGGCCCATCAGAAACAGAAGCATATCCAAACTTAA


GAAGTACTTAAGAAGGCAGGGGAAAGGAGGGAAGAAGAAGGGAGGGGAGGACAGGACAGGACAGGAAGGTGTTCATACAGTGTGCTG


TGAGCTAAGGTTAGAGTTTGGATTCAAATCTGTGTTATCACCTACTAGCCACTTAACAAGCTTTCTTCTTTCTTTTCTTCCTTCCTT


CCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTTTTTCTTTATTGAAAATAGATTTTTTTCTTACATAATACATCCTGATTATTTCCC


TCCCTCTACTCTTCCCACTTTCTCCCCACCTCCCCTACCATGTGAATCCACTCTCTTTCTGACTCTCATTAGATAACAACGGGCTTC


TAAGAGATAAGAACAAAAAATATAATAAGTAAGATAATATAAAAACTATCACATCCAAGTTGAACAAAACAAACCAACAGAAAAAAA


GGAGTCTAAGAGCAGGCACAAGAATCAGCCCCACTCGTTCTTATGCTTAGGGCTCCCATTAAAAGCACAAACCTGGAAGCCATAATA


TATGCTCAGAGGACCTGGTGCAGATCCATGCAGGCCCTGCGCTTGCTGCATCAGTCTCTGTGAGTCCTGGTAACCTCTGCTTATGTT


GATTTAGAGGGCCTTATTTCCCGGTGTCCTCCGTCCCTACTGGTTCCCTTTCCTGAGCTCTGAGGGGAGAGNNNNNNNNNNNNNNNN


NNNNTCTCTCTCTCTCTCTCCCCCCCCCCCCCAATAATGTCAGGTCCTCTGGTTTCGTTCCCATCTACTGCAGGAGGAAACTTCTCT


GATGATGGCTGAACAATGATCTACAAGTGCAGCAGCATATCATTAGCAGACACTCACTACATTTCTATCTTGTTTTTTAACACTAGT


AATACTTGGTGCTTTCATTGAGACCTCCTCCATATATGTATATATTTTAGGAAGTTTCTACTGCATTAATTTTCCATACTAACCCTC


AAATACTCCTTAACTTTAGCTGTCTCTCCCTGAGTTCCCTCACTCAGTTCCCACCCCTCCCTCCCCATGAGATCCTCCCATCCCAGC


CTCTCTCCATCCATCCGTAATTATATATTCTGTTTCCCTTTTCTAATGAGATCTATCTGTTCCCTCTAGTCTCTCATCCTCTATACC


TACCTTCTGTGGTTCTAGGGATTGTAACTTGGTTATCATTAACTTAACAACTAATATTCACATATTAGTGACTATATACCATATCTG


TCTTTCTGGGTCTGAGTTACCTCACTCAGAATGATCTTTTCTAGTTCCATCCATTTGACTGCAAATCATAATGTAGGGTTTTTTTTT


GTTTTGGTTTGGTTTGGTTTGGTTTTTGTTTTTTGTTTTTAATGGCTGAGTTATACTCCATTGTGTAAATGTACCATATTTTCTTAA


TTCATTCTTCTGTCTGTTGAGAGACATCTGGGTAGTTTTCTGACTATTATGATAAGAGCAGCAGTGGACATAGTTGAGTCTTTGTGG


TACACTGAAGTGTCCTTTGAATATTCCCAAGAGGAGTATAACTGGATCTTACAGTAGATCCAGTCCCATCTTCCTGGGGAACTGCAA


CACTGATTTCCATAGTGTCTGTACAAGTTTGCAGTCCACCAGCAATGGAGGAGGAGTCTTCTGCTTATTAAATATCCTTGACAGCAT


GGACTGCCACTTGAGTTATTGATCTTAGCCATTCTGACAGGTATAAGATGAAATCTCAAAATAGTTTTGATTTTCATTTCCTCGTTG


GCTAAGGATGTTCGACATTTCTTTAAGTTCAATCAGCTTTCTTGTCTATGATATGGAACTTAAGTTAGAATGTTTCTGACAAGATTA


TATAGAATGACATGAAAATGCATACCAAATAGAAGCCCTCAAATACAAAAGCCATAATAACCATGATATGTAGGTAACAGTGACTAA


TTATTTGGTCTCAATAAAAATAAAATAAAATAAAATAAAATAAAATAAAATAAAACAAAACAAAACAAAATAAAATAAAATAAAATA


AAATAAAATAAAACTTGGATTTAAACTGTTCTTCTATCATTTCCAGCAGACAGGGACGATATGTCCCTCACTCACAGCTGGATTTTT


ATTGCATTTCCCAACAAATGGCTGGCATTCCAGAAATTTCTTTTAAGTGAGAGGATCAAATCCATCCTTCATCTAAATAATTCATAA


ATTAATAACCCTGCTGAGCTCTGCCTACTTCCTCGCCTCAATACTCGTGTCTCCAACCTGACCGATTTCTACTATTGCAACACTAGG


GTTTTGCCTTTCTGGGTTTTGGAAAGGTGTTTGTTTGTTTGTTTAATTGATTCATTACTCAAGAAAGCTTACAGCTCTCCCATTGCA


TAGCAGTCCTTACAGTCTAGACCAGGCTTTAGGAATGAGCAGCAAACACACACACAGTTCAGATAATCCTGGATAAACAACTGAAGG


AAGCTTGCCATTGCCACCACCCTGATGTGCTATTTCCTGTCTTCTCCATGGAAGACTTCTCTCTGCCGGAATACTTCATCCAAGCCT


TAAGTTCTGACTTCACCGCACTCCTTGGACTCTTTCTATAGTTCCCCGATGGCTTCTATAAGAAAAGAATGGCCCCCGCATTCTTCC


CCAACCATGTCTGTCCCACTACTCTTCACCCTTCAGAACTGCTCAGTCCACTTGGTGACACCAATGTCATCCCTTATTTCTGTGCCC


TTCTCACCTTAACCACCCTCTCTCTGTGTTCTCATGCCAGCACAGCGTCAACCTTCACTTGCATGATTCCTGTGTTCTTGGTCATAA


TTTCCTTCAAGTATCATCCATGGTATACCCACCTCCTCGGCGCGCGAGAGCGCGCGCACACACACACACACACACACACACACACAC


TGAATGTATTTTACTATTGTTACTTAATTCCCTCCAGGACTATACTTTTTTTTTTTTGTCAGAAAGTAACATTTTAAAATTTATCTT


TAAAGTTCATGGACAATGTCTTCACAAATATGAACATTTGACTAGCAATTGTCAATATTTTTATAAATGAATTTTTCATGAGAAGTA


ATTTGTAAAATGGGTACAGAAACATTATCTTTTTTTAATAGGAAAAAAATAAGGCCTTCCTCTGTGCCCTCATCTCTAACTCTTGGT


GTTTCTTTTCCAGCTCCTGTCAATGGACAGCATGGTGAGTCCTTTCTACTGCTTTGGGAGTGCTTGGAGAGTTTCTCCCTCATGCCA


ACATTTTTCTACTCAGGCTATCAGGGACTTGAAAGTGATGGCTGCCCCCTGGTATGGTTCCAAGCCAGAGCAAGTTCACACTGCCCT


CCAGCACTTGCTGGGTTAGGTGGTGAATGCACAGGCTGCCTGGGTCTTTCTGAGGCCCTGAATTGAATCCCATTGACAATGGACCCC


ACTTAGCAATGAAAAAAAAAATCATCTTTGTCTCTGCCTTAAATACAAAGGGCTCGGGATGGAATCCTTTCCAATCAGTCAACTAGG


AAAATTGTGAAACTTTCAAGATGCCAACAGTAACACTGTTTCCTTTGCTGTTTTAAGAGTAAAATTCTCCAGGAAGTGCAGGAGGAG


TAAGAGAGTATCCAACCGTTGGAGCCTGGAGAAGTGTAGAGGAATAGAACCAGAATGAAAATGTATGTGCCACACACACACACACAC


ACACACACACACACACATTTGTATATAGCACAGAACTTAAGTGTGTTTTAAAATAGCAACAGAAGCTAAATCACATCCAAGAAGCTG


AGAACTCATAAGACACACAGTCAGAGTAGGTCCTAGAATAGCTGTCTCACACTAGAGTGGGGTGACTAGTAATTTATTCAGTCTACA


AGGCAGTAGGCCCTAATCTGGCATTCAAAGTCTGGATGGTTCCTGGAGCCTCTGGTCCCAGTCCATGATGGAAGCTTGGAATGCTGG


TTCTGCTGTCAGTGGCAGAAGCAGAGGCAGCAGCTACAGGGCAGATCAACTCAAAGGGAAGGCCAGGAGAGCAAGGGTGGGATACGC


TCCTTCTGAAAAACTGTTCTATCTGGGCTGCTACCCAAGAGTGCTGCCCACAATCAAAATGGATCTTCTTACATCAATCAAGATAGT


CCATACAGCTCTTCAGGTAAAGTTCCCTACTCCAGTGATTGTGGCAGGTTAGCATGAAAGCAAAGAGAATTATCACACATTTTCTCA


GTCCGCCATCATTACTAATTTCCTGGGTCACAGGTGTCTTGGGTATTTGAGGATCCAAAGTAATATCGAGAAGTCTCTCCCTTCTCC


CCATAGCTAGCCACCCGGTCACTCGAGTGTCTAGTTCCCCTGGGGATCAGCAGGTGACTGTCCATTCCTTATTCTGACACAACTAAT


GACAGTGGGTTATGTAGCTATATCATCCTCTACGAAACAGCAGTTAAGTGCATGATCTCTCAAGCTTTTCTAGTGTAACGCCCGATG


GTAAAATGATTCACTACCTTAGGGGAAAATGCAAAGTTGTGATTGTAATGATTCTGAAATTCTTTGAGGGTTTCTGAATGACAAGAT


AGCAAAGGAAGAAGAAATGACTTTATCTAGGATCCATTCTCAGAGCAGGCTTACTAACCACACAGTGTTACAGTGCTAGAACTATCT


CCAGAAATTGTCTTGCTCCTTGCCATCCCTGGGCAATCACTCTTCCCTGTGGGTGGTGAGTGCTCCTAAATGATGCTTCTTCAGCCT


TCAATGACCCTCTGGGTGGGCAGGGGCAGGGCACGAATTGGGGGGGGGGGCACCGGTGACACAGGAGGACATGGAGGGGGGATGGAC


ATGAAGACAGGGGAGGGGGAAGGAACACTGTGTTCTTGGGAACTGTCCAAAGCCAGGTCCTTNNNNNNNNNNNNNNNNNNNNGGCTC


TTCTGGATTGGAAACTGTGGGAACATCTGCTACAGATTCATTTCTCTCCTCCTCAGAAGCTGCACAGCAGTCTGTGGTTTCCCTTCA


GCCTCCATGGACCACTTTCTTTCGAGGAGAGGTCGTCACACTGACTTGTTATAGATTCGGCTTCTCCGTACCCCAGAAAACAAAATG


GTACCAGAAAAGAAAAACAGTGAAGCAAACCCCAGGTGCTTTGGTAATTAAAGCACATACCTTAAAGGTCCATGAGTCCGGAGAGTA


TTGGTGCCAAGCCGACAGCTTACTTCCGAGCATGCACGTGAACGTAGAGTTTTCTGAAGGTGAGACAGAAGTAAAAGAACTGAAGCT


TCAGACACCGTTTCTGTCCAATTTGCCCTGTAGAGTTAATTATTACTTACCACAAACAACTCATGAACAAACCATTCTATTTCATGC


TATGGTTACAGAGAGATTAAAAGTGTCTATAGAGAACCAGATATGGCACAGAATTCATGTAAATTTAAACATAAAAATTAATAAAAT


TTAAGTAGTCTGAATAAAGTCTGCTCAGCCCAGTAGGCAGTGACTTTGACAAGTGCATACAGAAGGTCATAATTGTCACTCACTGCT


CACTGAGTTCTAGATCTAAATACATTCACTCCTATCCCTGTGGTCCTTAAAGTCTAGCACAAATGAGAAGGCTTGCTCAGCTTTGTG


ACCACACAGAAATTCAGGAGCTACTCAGGATTTACAAACTCAAATCTTGAGATTATTGAGCCCCAAGAATATGTACTGTTTATAAGA


TGCTCATGTAAATGAAATTTGAGAAGCAATTTACTTGCATACTTCTTGAATCCATTTTGTTTATTAGGAATAGTAAGTACCATAAGG


ACTTTCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTGTCTGTGTAAATATTAAATAGATAGAAATAAATGG


ATTGATTTTATAGGTACACAAAGAGAGGAAGGGGAGAAAGGGAGGGAGGCATTTTTGGTTTTGGTCTTGAAGCCTTCTGTTTTAAAG


TTGAAGTAGTGTCAGCCTTGTGAAAATAGTCTTTGATTTTGTGAGCAAGAAAACATACTATTAGCAAGCAAAAGAAAAAAGTAATAC


TCTTTGATCTCATGATTCTCTTGAACATTTACCTAACAAAGCACACAAATCTGCACACCCCAAAATAAAAGGCACTCCATTGAAGGG


AGACCCCATTAAATGATCTTGAGAGTATTGAGAGAAAACTGTGGCTTCTGAAAATTTAGCTGCAGTGATGGTTCAACTTGAAGGGGC


ACTAGACAAATGAAAGGCAAGCCGGCGTCATTTAAATCCCCTTAGAGTGACAGACATACAGAAACTCTGGTGTACTAACATGGAGAA


GGGACTGGAAGACTGTGTTCACAATGATGCAGGGAGCTTTCTAACTCGCCTTCTGCTGCCCAGCTTTTCTCAAGGTGCAGGTGTTTA


TTTTTAGTTCAGAAAAAGAATTCATGCTTTCTCCACTTCCGCTTCCTATAAAGCCTGTGTAGAAAGGCAACAACAAGAAGAACTGGG


AGGATGAAACAAGTGGTGTGCCTGATGTGTTCCACAGATTTTCTGGTGCTGCAAGCTCCACCTGCTGTGTTTGAAGGAGACTCTGTG


GTTCTGAGGTGCTACGCAAAGAAAGGCATAGAAGCAGAGACCCTGACATTTTACAAGGATGGTAAAGCTCTGACATTACATCATCAA


AGTGAGCTCTCTATTCATCATGCAAATCTGAAGGACAACGGTCAATACAAATGCACTTCGAAGAAGAAGTGGTCTTTTGGGTCCCTC


TATACTTCCAATACGGTCGGAGTTCAAGTCCAAGGTAGGGCTTTAATTATTCTGAACAGGTTAGTCAGAGACAGGCTTCCTGTGGAG


GTAGAATAGGAAGAAAGAGTGGGCTGCCAGTCCATTGAGCAGAAGGACAGTCTTTGGGTGGGAGGATGTGGGTAATCAAAACCAGCA


CCTCCCTCTAGCCAGCACTCGGGGAGCGGTACCACTCCACACCTCAGTGCTGAGGATGAAATGGGGTTTTCTGCAGACTACTTAACT


GCTCAGTGGATGATTGTGATCCTTTGTAGAGTTGTTCCCACGGCCTGTGCTGAGAGCCAGACCCTCCCATCCCATAGATGGAAGTCC


AGTGACCCTGACGTGTCAGACCCAGCTCTCTGCACAGAAGTCAGATGCCCGGCTCCAGTTCTGTTTCTTCAGAAACCTCCAGCTTCT


GGGGTCAGGCTGCAGCCGCTCCTCAGAGTTTCACATTCCTGCCATATGGACTGAAGAGTCAAGGAGATACCAGTGCAAGGCAGAAAC


AGTGAATTCCCAAGTTAGAAAACAAAGTACAGCGTTCATAATCCCAGTGCAGAGTGAGTATCATTCTGAGTTTTTTTCCAGGCATGG


AAGCTATTTAGAAGCATTCACCAGTTTGGGTCACTAGCCTCTATAAAAGGTATTTTTCTCAAACCTGTGGAAGTTGTATGGCTGTTG


TGGATAGCTAAACTGAGGAGCTTAGAACCAAGAAAGAAAAACAAACCAACAACAAAAACCATGTTCGTTTTTTCTCTCGATGCCTTT


AGGGAAAGGCTCTTCTGGTCTCAGCCTGACATGAGTTTTCCTTCCAACGCTATGATCCTAAACTGTAGACTACTAGGTGTTGCATGT


AGCTTTTGCTACTCACCATAACTCCAGGAATGGGCCACGCTACCAGCCCCCACCCAGCTTCCCTTGAATCCATAGATAAAACACACA


CACAGAGTTGTTCATTTTCAACTTGCCTTCTGGGCACAATTGCTGAGCATTATTAAACTCTCGCTGCTAACATGCCCTTATCAATTT


TCTTAACTCCGCACCTCCCACAAGCCCTAAACTTTAGTTGCTCTGTTAAATCTCGTCCCTACTAAACATCCCTGACCATTGCCTGTT


GGATAGCCACTTGCGTAGCCACTCTATTTTGAGATCTCACATGACCTGCCAACTTTTCTCCATCAGAAGCATGGTGAACTCTGTCTC


TCTTCCCTTGAATCTGTCTCTTTCCTCCGGGAACCTGGAAGTCCCCCTATTCCTTCTGCCCAGCAATTGGCCCATGGCCCCTTTATG


GACAGATCAAGAACCAACTGGGGAACAGGATAGCATCAGAACCATCCCTACAATGTGGTCAGCCCTCAGACTGGGCTGAATGTTCTG


TTCAGCCAAAAGGACAGGTGTCCAGAACATGAGGTGCCTGGTGCAGACTGGTTAAGGACAAGAAAGCCAAAAGATGAAGTCTTGCAG


AATAAATAGATCCATCTTGATGCCCTTAGAGATGGTCTTTCACAGACTAACACTTTTTCCTAAGGCTCAAAAAAAAAAAAAGTTTTC


TTAAGCGTGATCATTAGCCAGTGGCTTTGCCTGACTGAATTTGGCCTATCTCACAGGAAATCTAGTTGAGCATAGTAGGGGACACAT


AATCTAGAACACCTAGATCCTGGGTCTGGAGGGAAGGGAAGTGAGAGCATCACCTATGAATTTGTTCCCATTGCTAAGAAACCAATC


TGACTGACTAAATTCTATCAGTCTACTCTTTGGTTGTAAGCAATGGGTGCTCCTGTGGCTACTGATTTAAAGATGAACAGTTCAGAG


AGGAAAGAGAGGGCATTATCCATCAGTCACATCACAGTTATTCTTAGCACAGTCTTTCCTTCAACCTAATTGCTGAACCATCCCATC


ATCCCCATCCTCTAGTCAACTATCATAGTTTGTTCATTAAGTCTGGAAAATAATCCAAAAGGCACTGTCCTAAAACAGTATGCCTAA


AACCATTCCCAGGGTGGACAATCCTTCCTTGTGAGTCGATCCTGGACACTAGAGAAGTTAAGAAGTGCCAACTCAAGGCCAGTTCAT


TACTTATGACAATGCTTCATTTCCAGTCATACACGACTGGCACTGTACTCAGGACTATCATGTTTGATGCCAACTCTCTTGTTTCCT


TCCTCCACTTTTCCTAAGTGTTGAGCCATGGGTAGCAGCTCTGGAATTATCAGGATAGGGCAGACATGAGGTCAGGTTGGGCAGAAT


AACCTACAGTCCTGCTACATATCCTTCACAAGGCCCTCAAGGAATGTGGGGCCTTATCAGCTGGCAGAAAACACAGTCTCCATTGTC


TTCTCACTTCCCAGAGACAAGCCTAATGTTACTCTAGGGCCCCTCCCCACATGGTAAAGCAGGTTTTGTCTTCTTTCCACCCCTCAC


CCATTGCCAAAAGTCCCATGCATGTCATTGTTATTCATTTAGGAGCTTCTGCGAGATTCCAAACACACATCATCCCAGCCTCAAAGT


TGGTGTTTGAAGGGCAGTTGCTGTTACTCAACTGCTCAGTAAAAGGAGTCCCAGGACCCCTCAAATTCTCCTGGTATAAAAAGGACA


TGCTGAATGAAGAAACAAAGATTCTTAAGTCCTCCAACGCAGAATTCAAGATCTCCCAGGTGAACATCAGTGACGCAGGGGAGTATC


ACTGTGAAGCTACCAACAGCCGCCGAAGCTTTGTCAGCAGGGCATTTCCCATCACCATAAAAGGTGTATGTTACAATATGAACTAAC


CAGTACCTCCAGAGCTCATGTCTCTAGCTGTATATGTAGCAGAAGATGGCCTAGTCAGCCATTATTGGGAAGAGAGGCCCCTTGGTC


TTGCAAATTTTATATGCCCCAGTACAGGGGAACACCAGGGCCAAGAGGTGGGAGTGGGTGGGTAGGGAAGCAGGGGTTGGGGAGGGT


ATAGGGGACTTTCCAGGATAGCAAAATGTAAATGAAGAAAATACCTAATAAAAAATGTATAGTTAGGAGGTGTTAGTATATTCACAA


ATTGCCCAATTCTGTACTGTTTGCCTCTCAAACATGTATTTCCCTGGGACCTACAGTTGTTGACTTGTTTTTAAAATGAGTTGTTGC


TAATGCCATTAAAAAAAAAAAAAGTGTGTGTTGCCAGGTATATCTGAGGAATGGATCCCTCACATTGCACATGGGGATCCTTGAGGA


AGACTTGAAACAGTCAAAGTGGAAGTAGATGTTGTCAGTTACCAATAATTCAATGTTCTGAATAACTTGCCAAGTATTAGTCAAAGA


CTAATAGGAAAGACTTAGAAATAGATGGAATGGGCTGAGGGCAGTGGGAGCTCTCAGAACATCAGATGGAGGAGAAAACACTCAGTG


ACTAGGAACATAGCCTTTGTAAGTCCTCCTCAGTTAAAATGAAATGTCTCTTTATAAAGGAGGAACAGATGGGATGCCAGAAACAGT


ATATCTTGAGAGATGCCTCCTGGCATCTTACTGTAACCAGAAGAATTCTCAGGGACCCATCCTGGCCATGCTGCTATGTCTTCAAAC


CCTAGTAGCTCTCTTATTTCCACTCTTGGTCTCCTACAGTGAGATGCTATGGAGAATGTAGTAGAGCTTCACCAAGAGGCTGAGGGC


TTCTCCCTCTGACCCAACATCTGCCTGTTGGTTTTAACATGAGACTGAAATCCTCTGTTCACTGAGCACTTGCAAAATTATTCCCAT


GTCCAGGCCAGTGGAGCAAGGAGAAGCTATTGTCCACCAGAAGTAAGCAGCTCCAGAAGTCATATACAGGGTCAGGTTGCATGCTCC


TAACAGGCTACAGTTACCATCCACAGAGGCTCCTTACTTACCCCCCTCCTGCTCAGCTTCTAATATTCTGATAGAATGGATGGTTCT


GGGTACCTGGAAGAAGGCAGTACTTGAGGAGAGCATCCTGCAAGAGTATGTGAATTTAGCAGCTTAAAGGTCCTGGAGCAAAGCACG


GAAGTTACCCTAAGTAGAGAAATGGAGAGCAGAGACTGACACAGAGACTTAAAACTCGGGAGAGGAAATGGGCCACAGAGGAGCAAA


GAGTTGATTGAGAAAAGGGTATCAGTCCTATAGCAGCAAAATACAAACTTCTCCCCTGAGGGTACCATCTCTGTAAAATTGAGGAGA


GTTGGCTGACAAGGGGAGCCAGAAGGGATAAGGCAGATTGGAAAGGAACTGATGGAAGGCCATCATGGACGTCAGGAGATTGCTGAT


GTCCATCCAGCCTGGGAGGTTGAGCTGTCCCAAGATCTGGTAGAATGGAAACCAAGTATGTGCATTGGAACAAAACAAAAGTAACCT


GCAACCCACTTTCTTTCCTCCAGTCCCAGTATCTCAACCAGTTCTCACCCTAAGCACAGGCAAGACCCAGGCCCTTGAGGGAGACTT


GATGACACTTCATTGTCAATCCCAGAGGGGCTCTCCATGTATCCTGTATGAATTCTTCTATGAGAATGTCTCCCTGGGGAATAGCTC


TATACTCTCTGGAGGAGGAGCATACTTCAATTTCTCTATGAGCACAGAGCGATCTGGAAACTACTACTGCACAGCAGACAATGGCCT


GGGAGCCCAGTGCAGTGAAGCTATAAGGATCTCTATCTTTGGTAAGTCCTGGGTTCCTGCTGATACCCACCACTATACAGATTTCCC


TCTCACCAAACCCTTTTGGAAATTTGCCCCCACACCTTTACTTCCTACCATAATCACCTCAATCCTGTTCTAGGCTCCTATCTCAGT


CAAGCTCATTGTCTGTGCTTATCTACCTCCTCGCTAGGCCTGACTTTTGCCTAGCTCAGAAGCCTCCACAGCTCTTAATAAATGTGT


GTGGTCATCACACTCTGTCTTCTTATGCCCTGTAATGTTTAGTTCCCAAGCTAAGAGCATCAACAGGGGCACCCAGTTCTCTACAAG


CACCTATCATCTTCCCTACAGAACAGTGGCATGAACAAATACTATGCAAAACCTTAGTTTTTCCAAAGAGTTCCAAGCAATTACAAC


TCTCAGTGTAGGTTAGGAGGAGACTGGATTTGAAAGAAAAGGAGAAAATGGCATCCTTAGGAAATGTGTTCCTTATTTTCTAGGGTT


TTCATGAGCCTCTTTCTAGAAGCCCATTTAAGCAAATTTAAATTCACTGCATGATGTAGTTTTCTAGACCTTTGTTAGAGGGTGACA


GGATATGCGTCAGATCCAAAAGAATAGCTAACTCTGGTGCCTATTAGCATACCAGAGTGCATGTTGGCCTCTAGGCTCCCTCAGCAA


GGGCCTGTTACAGAGTCCTGCTCTGGCACCCTGGCTTCTCTCAGTCCTTCTCACCCCACCCCCTGCCCTAAACTTCTCCAACCCATG


AGTTTCCCTTGCCCCAGCTTCTCATTTCTACATATAATCCTGCCATTTGACCATGCACTCTCTTGGTTCTCTTTGCCCTTTTGGCTT


TTGGCTCTCTCTCAGTCAGCTTGCCCCTCTCTCTCTTTTGCCTCCCTCCCCCCAAACCTTGGTCTTCCTTTCTTGCTCCTCCTGCCC


TCCTCTCATGGCCCAGGTCACTCTCGTGGCCATATGCAGACCACTACTTTCTCTCCCTGCTCTGAACTCTTCCAGGTGTCTTTGGCT


GTACTCTCCCTCATAACTACAATCAATCGGTCAATCGATTGATCAATCACTTCTCCTCAGCCACACCTTAGATCAGTTATATTCTCC


TTTTGTTCAATATATAGATCATGGTTGGTCTCTGTCAAGGCCACTAGTTAACATAATGGAGCCACTGAAGGAACAAATGTGCTTGTA


TTTGCTCTTAGGAGAAAGTAAAAACCTAGCTGTTTTTTTGTTTTTGTTTTGTTTTTCAAAGCAGTAGAACAGCATTGTAGAAAAATA


TTGAGTCTAATACGTCAAACACATCTCCTTTGTATCACAAGGAAAAAGAAACCCAGGAGCCCTGGGTAGGTGCCAATTTTTAATACG


GCTGTTTTGAGAGTAAATAAATAAGAAAGACGACATAGGCAATTCAGGGAAGAACTAGAAGATTTCTCACAATGGGATATATTTCTC


AAAATAGAATTATTGGGTTTTGGGGGAGCGGTTGTAAAGTCTGAGGCTATGAAAGCTTACATAATGAGGATCTAAGAACGTGTTTTA


GAGTTTAAGTTAGATGTGCAAATGCGAGTTATAAAGGTTAGAGGATGTGAAAGCTTAAAGAGTGATAAGAAAGTGAGTTAAGGTATA


CAAAAGGAGGAAAAATGCTTCAGATTCCTTCCCCTTGATATGCTACTGCTGTATTAAGACTTCAAAATTCCAAAGTTTTGACATTGA


CGACTGGAGTTCTGCTAATATTGTAGACATAAGCTCAGAATTTTAAGTTTCTTTTGGTTGTCTGCTAAGTATAGATTTAAAAGTGCT


TCTCATTGTGCTAAATTTACACACACGCACACACACACACACACACACACACACACACACATCCAGTCTTCTGGATAGAGGAAAGAA


GCCACTCTTTCATGGTTTGCAATCATACTGAAAATCAAGATCAAGCAATCTTTTGCCATTTCTGCTCCATGGAAGGTTTCTGTTTTT


CTTGAGCTTGCCTTAAAGAGTGGTTATGCTGTTAACCCAAAACTATTTTCCAAGCTTCTACTATGACACAAAGATGTGAGTATGTGA


GTTTGAGTATGTGAGTATGTGAGTTTCAGTATAGACTACAAATAGTCGTAACACTAACATGTTTAAAACTTGTCTCTTTTTGTAAAC


TTAAAAAAAAAAAGATTGTAGTAAGCTTCAGGGGATCAACTTGAATCCACCTCTCATGGGTCAAATGGACTCCAGAGAAATACCCTT


ACCAATCAATCGCCTAAGGGGCCCAACCCATTACCTATTCCAGAAGGTGGGGTCCCTTACTCTTTCCCTGGTTTAGGGGCTCCTCTC


CCTCAACTACCAGGACCATGTCTCAAATGTATACAAGAAAAATTTCCCCCCAGACTCTTTAATTTTACATTCTGTCCTAATATGTGT


GTGTGTGTGTTCTAGCAGATTTCCAATCAATTAAAGACTATAAGCTGCTCTAACCACTGCCTGTACATCCCTAGCCCCAGATGTTCT


TGCAGAGCCTAGACACAACTTGTTCTTCCCAGACTTGACCAACATTCCAGCTTCATGCCCTTCCATCATTTGATAAAGATCAAATCT


TTAGCAGGAGCAGTCCTGACTGGGTCTCCAGCCTTCTACTCCATCACAGTTACTGGGCCTGTCAGACTGCTGCCCTACCCTCTGCAA


CAATTCAAATGGACCAACCTGTCTTCAGTCACTGCCCACACTGCCTGCCTCATAACCTATACGTAGTCCTCCCATATCGGATATGGC


CCCTTTCCACTGCAGGTTTTGGCATAGTCTCTGAAGCCCACTTCTTTCTCTTCTAGCAGTCCTCATCTCTCAGATGCCCAGCTTTCA


GCTGTGTCTTCATTTTCAGATTCCTCAAACATGTTTGTGTTTATGTGTCAGGTACTTCAGAATATATACAACACTATGCAAACATTC


TCACTTCCCACATTGGGATAAATAATAATTGAGCGCTGAAGAACCTGAAAAGGTCACTAAAACCTAATAATGACATTTTGCAGTCAG


AAATGCCTTTAGTCCCCTATACCCTCCCCCTGCCCAGCATTTGAAATGTAAATGAAGAAAATAGCTAATAAAAATTTTTTTAATTAA


AAAAAAAAAGAAATGCCTTTAGTGTGGAGGGCTGTGTTCAAATGGGAGAAACCGATGGCTGGTTCATCTCCCTCAGTTCCAGCGTCC


CACCCTACCCTAATCTTAGACGTTCCCAGGGGCCCAAGCTGTAGTGTAGTGGGGGGGGGGGGTGAAGCTAAACTGTGAGACCCTGGA


AGGCTCCCTTTCCTGATCTTGTACCATTTTCATCCTGAAGATGTCACCCTGGGGTGTAGGTTAGCCCTCTCGGAAATAGGAGAGTCC


TTCAACTTCTGTCTGACTGTGGAATGCTTAGGGAATGGGGTAGTTCTACTCCAGTGAGGCTGGCGATGTCCCAGGGCCCTAGCACAG


TGAGGCAGTGATGGTCAGTATCACAGAGACTTGTCATAAGCAAGCGCTGGCGGCACCTGCTCCTTCTGGCCGCAGGAAAGCTACTTC


CTGTTGGTATCTTCACAGCGCTCCTTTCATCTCTCATCCTCTCTAATCTTTTGGCTCTCTTCCTTTTATATTTTACCTCTTTCTTTC


TCTCAATGTCACCTCCTACTTTCTTGTCTTTGTTTTATTTTATTTTATTTACTTACCTTGCCCCACTGCCTTTAATTAGGGTTGTAT


GCATAAACAGGGGTTGGAGTCATTTACTTGAACTTGCCAGATGCTATATTCCTGAGGAGTAAGGCATAACGTGTTTTAATATCAGGA


TTGTCCTGTGTGTTTAGCTATAAAACCTTTATTTTTAAGCTTAAAATAAATTCTATGCATCTACCCAGTCTATTCGGTTGTCTACAG


GTTTTGTTGTGTTACAGAAACATTAGAACATAGAATTCTTGCATGAACTATATACATGTACTATATAATGTTATATATAGGCATATA


ATGTATTATCATACAATATATAACATATATTTGAAAATAAAATTTCCATACTATATGATTTTCCTCTCCCACATCCCCTTCATCCAT


CTCCATGCCCTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTAGAATACAATCAAACAAACATTTTTTAGAAAG


AATAGCAAATAAATAAGAAAAGGCACAAGAAACATAACACAAATCACACACACACACAACATAAAAGCACAAAACATAGAAAGTATA


ATACACAAGCAAAAAACCCAATAAGATTTAAAAAAATGCCCAAATAAAGCAATTTGAGTCAAAAGTGTACAAAAGCACCACTGAGTT


CTTTTCGTGTTGCTCATCTGGTGCTGGGCATGAGGCCTACCCGTGACTGTGGTCGTCTTGGGCACTGCTCTATTGCTCTGAAGGGAC


ACCATGACCAGGACAACTCTTATGAAAGAAAGTGTTTAATTGGGGCGACTGCTTACACTTTCAGAGGTTTAGTCCATTGTCATCATG


ATGGGAAACATGGTGGTAGGCAGGCAGGCTGGAAGACACAATTTGCTTGGTGTCACCCATCTCTTCAATCCTTACGATCTTTTTACT


TCCTCTTCCCCAACGCTCCCAGAGCCCTCAGTGGAATAATAAAGACATCCAACTTAGGAATGAGCATTCTAAAATCTCTCATTCTCT


GCACATTGGCCAGTTGCAGGCCTCTGTTCATTCCCATCTACTTCAAGAGGAAGCTTTTCTGATGGAGGCTGAGTGAAGCACTACTCT


ACAGATACAGCAGAATGTTGCTAGGAGTCATTTTATTGCTGTATTACTTTAGCAGAACAGTACTGTTTCTTTCCTCCTTGCCCCATG


TCCTATTTGCTTTCCTCTTAGTCTCAGGTTCTTGGCCACTAAAGCAGTGTCAGATATGGTTTTCATCTCATAGAATGGGCCTTAAAG


CCACTCAAATACTGGTTGATTACTCATCCAGTTTTTGTGTCATTATTGTATCAGTAAATCATGGAGGCAGGTCAATTTTGTAGATCA


CAGGGTTCATGGCCAGGTTGGTGGACACCTTTTTCCTCTGGAAGCACTGAATACACATTTTTTTACCTACTTGGTCCTCCAAGTAGA


TTGTGGGCTCCAAATTTATGCATTTCCTTAATTTTGTAGATATTGTCAAACTACCTTTCAAACGACTGTCCTCAGTTTCCTTTGCCA


CAATTTCATCAGTATTATCAATCTATGTAGGCTTGAAAAGGATAATAGTTTATGGCTGAATCTAATTGTACATTTAATTAATAATGA


AAATGAGTCTTTAATATATTTGTTGGCAGATGTTTCCAGTGATGCATATAACACTTTTCCCTTTTCTATTGAATATTTTTGTATATG


AAAAACTACTTGTGGATCAATGTCATTAGCTTTTGAAATCAGATGTTTTTTATTTTCTTTAATTTGCTTATAATACTACTTTTCCCT


TGTAACTGCAACAAATATGTTAGACGCAGAAGCTTCTACTGAAGTGTCATTTCCATTCAGTTCCAGTGTCCCCTCCCTGTCCTCACA


CTCAGGGTGTCTCAGGAGCTCAGGCAGTGGTGGCTGATACGGTGGAGCTTCACCATGAGGCTCTGAGAGGCTCTCCCCCAAGTCCTG


TACCAATTTTACCGCAAAAAAATGTCACCCTGGGGAATATCTCAGCTCCCTCTGGAGAAGGAGTCTCTGTCGGCATCTCTCTGACTG


AAGAACATTCTAGAAACTTCTGTGAGGCTGACAATGACCTTAGGGTACATACTTTTCATCACTGGTAAATATGCTTTAACATACAGT


GTTCACCATGGCTGATCAGGAAAGCGCTTCTCAAAGGCAGGTCTCTTGAGCTATTGGCTCTCTAAATCATTGTGTTTTGGTTCAAGA


GAGCCAGGCTTTAAAGAGTATCTCAGAACTTAGAATTATCAGCTAGCTGCTCCTTCTCTCTGACCACAGTCTATCTTGACCCTTTGC


CTTTCCTTAGGCACAGAGACAAGCTTTCTCATAAACAAATGAGCCATCTTCTGTGCCATGTCTGTCACTACTAAGGCTTGGTACTCC


TGGTCACAAAGGTTCTTCTCCTCCCCAACACTAAAACATCAGATTCAAGACTCAGAGCCACTCAAAACTGCCCATTCCTTCCTGGTT


TTATGCTTAGGTATCCTCTGTCTCCCCCCTCCCCGCCCCCAGACATGACAAAGAACAGAAGTGTTCCTATGGCTGCCGGAATCACTG


TGGGACTGCTCATCATGGCTGTTGGAGTGTTTCTGTTTTATTGCTGGTTCTCTAGAAAAGCAGGTGGGTGACTCCCTAATCACACCC


TTCCTGTCTCTGTTCCTGCTTGCTCACACTGAATATGTGACCATCCGTAGGCTCTCGAGAGTTTCTCCTCTTTCATCGTATGATTCC


TTGCCTTTCCCTCTGGGTCCCTCAGAAGTCCTGTTAACCAAATACAGAGTTGTTCCAAAAACTACCTGAGCGCAACACACCTTGATG


AGACGCCATCTACCTAACCTCAGAAAGGGTCCTGTGTTTATTATATTCCCCCGAGGAAGGAGAAGAAGAGAAAAACACTAAGAAATG


GAAGTCAAAACAGAATTCAAACTAGATTTCGTAGATTACTGATCCTTAAAATGTATAGTATTTTTATAGATGGTCAAGTCTATTTTC


TGGTCTAAGACTATTGAACTATCTGTAGTCATTAAAGACCACTATCTTTGAAAAATCCAGGTTAAAGGAGTATGGACTGAGCTTAAG


GAAGTAAGGACTGAGCTTAAGGGAGGATTGACTGAGGTTAAAAGAGGATGGCCAAAGTTAAGAGAGGATAGACTGAGGTTGAGGGAA


GATGAACTGAGGTTGAGGGAGGATGGACTGAGGTTAAGGGAGGATGGACTGAGGTTAAGGGAGGATGGATTGAGGCTAAGGGAGGAT


GGACTGAGGTTGAGGCAGGATGGACTGAGGTTGAAGGAGGATGGACTGAGGTTGAGGGAGGATGGACTGAGGTTGAGGGAGGATGGA


CTGAGGTTGAGGGAGGATGGACTGAGGTTAAGGGAGGATGGACTGAGGTTAAGGAAGGATGGACTGAGGTTGAGGGAGGATGGACTG


AGGTTAAGGGAGGATGGACTGAGAAGCCTCCCTTCACTTGGGGCCAGCATGAAAAAATCAGTTGCTTTTACCCCTCTCCCCTCTGTC


GGCATAGCAAAGATTCAGATCTCAGTAACAGAAGTTCCTGGCAGTCTCCATGTGAGCCCCACCTAAGCTGCCTCCTAGTCCCCATGA


AAGACCCCTCTTCCTGAAATTCAATGTGTTCCTTTACAGGAGGAAAGCCTACCTCTGATGACTCCAGGTAAGAACTTGGACATATTT


CAGGAAGTAATGTAAACACCCACAGGACAGAAATTTTAAGTCAAATCTCAAATCTTATTACCTTATTATCACCAAGATTACAATTTC


TATGCTCGTTGCTGAGGTGGGTTGTACCCAATTGATGCTACCCCTCCCTTGGGATGCCTCAAGTCAATTCCCAGAACCTTCACCTTA


GCTACACCTTAGAAGCCTCCTTCTCATGTCATGAGGCAATTGATTTTCATTTATTAAATCACTTCCTTGTACTACTGTGAGCTTGGT


TGTCTAAATGATCACTTTGGCAGTTACCAGGGAAACGGGTTCCCTTTGGAGATCCTTATTCTCATTAATAAAAAAATTTAGAAACAA


GCTAAGAAGAAAGCTCAATACAAATTTACTAGAATTTAATTAAAAAACAGGTAGATGAAAATCCTGGTGTTACTAATGAGGAAAGAT


GAAGGAAAAATTCATGCCTTTGAAGTTGGGCGGCATAGGATAGAAATAGTTTATTTAAAAAGGAAGCATCACTCTCAAGAATGGAAC


CAGACTAGCCAGCCAAGAAGAGAGTCCCAAAATCAGCCATCCATGTGGCTCCTGATCGTTATAGCACCACTCTCCCCATTTGTAAGT


CCTGGGCTTCAGATCACACGTGTTCTCTTTGTTAGATGATGCCAAAATGAGGAAGGGCTTCAGGTTTTCCTTCCTCTGCAAACTGGC


TTCCTTCATGTTAATCGTATCGCACAGTCATTGAATCCACCCACACCTTGAGATGACATATCTTAATTAGCCTAGAAATCTCTAGGC


ATGGCCTGCCTGATCAAAATCTGTTGCAATGACAGCCAAGAATGTGGAGCACATATCTCACACCTAGAGGAGTCATTCTGCAAAGAA


GTAGGATCTGTGAGAAGACTGCCACCATGCCACCATCCTGCATCCTGAAGGCTCGCTTTAAGAGTCATCCCACAGCTCACAAAGTGC


CATGAGCCTCCCATAGTGGCCTCATCCAAACCACAGGAGTTCCTTGGGGTCTTTGTTTGTAGAAGATTGTTGTCTCTGAAAGGGGTC


TCAGCCTGTTTTAAATCTTGGCTCTTCCCCTTTTCTAGTTTAGTGGTGATGGTAAGCTACTTCACTTTATAAAACACTCATTGCTTA


TGCATATAAAATGGGAACAAAACAGAACTAAATACTTACAAGTATTGGCATGGTGCCTCTTACATACCATGGGGGCACAACATAGAA


ACAGAACAATGTTGGTTGAGAACTCCTTTGGAGGGATCACTATTCCCTTCCTCTCACTCCGGGAAACATCAGTGTTTCTATCTCTTA


CAGAAACCCTTCAGATTCAGAACCCCAGGAGCCCACCTATTACAACGTACCAGCCTGTATAGAACTGCAGCCAGTGTACAGCAATGG


TGAGGACAAGAGCCCTCTGGTCTCGGGGTAATCACAAGATACATATTGGAGCAGAATCGGGAAGATGATAAAGCCTAGAGGGCTATA


ATCCTTCTAGAGAACAAACTGGCCAAGGGGTAGCTGAGAAGAGAGGGAAGCTCCTTATTCTCCTCTGAAATTCTGCCTTCTTCCTAA


ATAGAGCCTGAGGAAAACGTGATTTACACAGAAGTACGGAGAACTCAACCAAGACAGAAACATGCAGGTAAAAGCTGGAGACCTCTC


CGTCCCTTGCTATTGTTCAGCCTTGGCTTCTCAGCAGGTCTGGGCCAGCCAAGCCAGTCTCTTCACTAGGACGCTAGGATTCCTTAA


CTTGCACCTACATTGTTTGGAGTTAATCCAAAGCCATCATGTAGTGCTGCTGGCTTCTTCATTGTCTATGGATGAACTCACGATAAC


CCGAGTTACAAAACCATGACAGAGTCCCCTCTGAGCATCTGTGTCAGCACCTATAAGGTGGAATAGGGCTATCTATTTCTGGGTGCT


TTTCTAGTTCTGGGTGGCTGAAACAGAACCCTGTAGACCGGGCAGCTGAAATAACAAATATTTGTTACAGATCAGGAGTCTGAAAGC


CCAAGATCAAGGTGCCAGATGGCTGAGAAAAAGTAGGATATGTCTCCTCCAAGGTATGGTTGTGGAGAAGGTTTATTGTGGATATGA


GGGAGAACAGCCAGAGGGATCTGGATGAGTCCAGACTGAACTGGGCCATGGGGTGGCAGGGCAAGTGGACCAAGAGAGACCCAGGAG


CAGGGCAAGCCAGGGGGACTGGTGACCAGTCTCTGCTTTGATGTGTTAAATGGGCACCTTAGTTAGCCATTTGTCCTGAGTTTGAGA


CTTAACACTCTAGCCTTTTGGCTAATGATAAAAGATGATGGAATTTCTTCTATAACTACTTTCTGCTGAAATTGGGGTGTCATCAGG


GCCCAAGAAGACTGGAATATTGATCAAATATTCCAGGAAGGGACAGATGAGGGCAGGTTGGGGAACATCTGTTTCACTTGCTGCCCA


GGTTCTGAGGGACCGCCTGGGGCAAGGAAAGTGCAGGGCTGCTTTGGAGCAATCTGGCATGTGGGTTGCAAGGAACACTTGGGGCTG


GCACATTGCTGCAGTATTGCAGTAGTCTGCAGCTGTTTGGAACCTGCTGGGACAGATATAGACAAGGACAGAAGGTAAATTTAAGGA


GTTTAGGAGACACTTTTTTTTTTCCAAATCAAATATCCTTTATTGAATAAAACAATGCACTATAGAATATTTTCTTTAAACAACAGT


GAAATTTTAGAGTATTCCCATTAGATATACATATACCTTGGAAGATGATAGTTGTTCAATCACCTTTTATAAAAAGAAAAAATAAGA


TTTACATTTTACTTAAACTTGAATTTAGGGTTATTTGACTACCTTAATTATTTTATAGTGACAAAATACCAGGAAAAATTAAAGAAA


TATATTAATGTGATATATATATATATATGTGTGTGTGTGTGTATATATATATATATATATACACATATATATATATATATAATGTAT


TTTCCTCAATTACATTTCCAATGCTATCCCAAAAAGTCCCCCATATCCTCCCCCCCAACTCCCCTACCCACCCACTCCTACTTTTTG


GCCCTGACGTTCCCTTGTACTGGGGCATATAAAGTTTGCATGTCCAATGGGCCTCTCTTTCCAGTGATGGCTTACTAGGCCATCTTT


TGATACATATGCAGATAGAGTCAAGAGCTCCAGGGTACTGGTTAGTTCATAATGTTGTTGCACCTACAGGGCTGCAGATCCCTTTAG


CTCCTTGGTTACTTTCTCTAGCTCCTCCATTTGGGGCCCTGTGATCCATCCAATAGCTGACTGTGAGCATCCACTTATGTGTTTGCT


AGGCCCCGGCCTAGTCTCACAAGAGACAGCTATAACAGGGTCCTTTCAGCAAACGCTTGCTAGTGTATGCAATGGTAGGAGACACTT


TTTATTTTGGGTGTATACTTGAAAGTTCTAGGCCCATGGTCCTGGTAGTTGGGGTAGGGAGCAGCCCCAAAACCAGGGGTAGGCAGT


AGGTGGGAAAACTTAGGTTGCTGATTGACAGGAGTAATTGTCTGGAGTCCATTTGACCTGTGACAGACAGGTGGATACAAGTCATGA


CTTCCTGAAGCTTACAAGAATTTTTTTAAGTTTACAAAAAGATAAGTGTTTTCAACATATTAGCATGACCACTGTTTGCAATCTGTA


CTGAAATCTGCATTGCATTGTAGAAAAAGCAGTGGCCTCAGGCCTTTGAGGCAGAGTAAAAGCTTGGGACCATCAAGGCATGATTCT


GAGTTCAAAGCATCAACACTGCTCCTATATATCCTGAGGCCTGGTTATATAGGTTGGACAGAGGTGGTTTTAGCGTGATTGAGAAGG


TTGTTAAGTCTATGCTTAGAAGACAATTTTGAGCTTGTGACTGTAATAGCAGCAGTGACTTACCAGGGCTAGATTAATAGCTTGTCA


GAACTCCACTGATTAATGTTAAAACTGTGAACTTCAGAAGTCTTTATATGACAACAGCATGGAGAGAGGAAGCGATCTGAGATGGTG


TCATCACTTTAAATCACTGTCTTACACCTTTACAAAATGTGCGCTTACACACCTTAAATTACTACCTTAGACCTTCACAACTCAAGC


TTTCACGTTACCACAACCTGCATTTACAAACTTCCCTACAAATCACTTTCCCAGACCCCCACAACGTATATAAACGTTGGGCTTTTT


CTTTTCAGCTGATCATTTATCATGAGACACAAATGGTTGATTATTGAGAGTAGTCGCTGCAAAGCAAGTTCCTTTAAATAAAGGAGC


TGTACAGTTCATGAAAACCTGTTGTGAGTGTTTCTCTATCAGTGTGGTAAACTATGACTTTGTCTCTGAGCCAGAGACCTAGTAGCT


CTAGAAAAGTGAGTCCTGGTGCCTGCTTCTACATAGAAATGGCAGCTGTAGCCTCAGGGAGAGGAGCTGGGTACCTGCCACTGTTAA


CATACAGCTACAGTTAGCCATCAATATCATCAGAGGTCTGAGAAGGGTAAATTATAGCAGGAAGTACAATCCAAATGTATGTGTGTA


TCAAGTAAAATGGCAGAGAATGACTGCCACCTGGACGTTTGTCCTAGGCTCCTGTGGTCTCCGTGGCTTCACTGAGGGCACCGGTCT


TTGGTTGTCACTCAGTTCAGACAGCATTATCTCTTTCGCTGTTACACAGGAGAGCGTTGGCCTTCGACTACCAGACCCAGAAAGTCT


GAGAGATTCTTCTGTGGAGGAACTGGGAAAAACTGACCCACTTTGGCAAGGCAGAGTAGAGCAGTGAACACAATACTGTACATAATT


TGTCCAGAGCCCTGGTGGTAGGTAAGGCACAGGCAGTTTCAACCAATGGTTAGTGTGACGGCAATCCAGGTAAAGTATTCTGTACCC


ACCTTCTTCTTTTGAGAGCTTAAGGTTGCCTCTAGGAGCTTGCAGTTCTGTCTGCCATGGAAATATTTTTCAATCAAACATGTTAAA


TGCTGTATTAGTGGATTTCTGTAGAAGTTAAGTCCTGGTTCTTTCTCCCAGCCCCATGCTCCCAAAGTAAGACTCAGATTCAAAATA


TATTTGCAGATACCTTGGCCACACAGTTAGGTCTTTAGTTAGATCTCCTCTGACTAAATCATAACTAAAATAACTCAATTACTTAGC


CTGCATTCTACCATGTGGCTGGTTACCTGTGCTCAGGTACCATGAATCTATCTCCTCGCATCTCCCTGGGTAGATCTTCAGAGCCTG


ACTCTATCCCAGAATTCTCTCTCCTCCTGCATGTCTCACCTGCTATTTCCTGCCTAAGCCATAGGCCGTCAAATTTATTATTGGCAG


GTGCCACATCCGTACAGACATAAGATATCTTCTCTACAGATCTCTGAAGACTTTGAGGATCATTATCTGTTGTATATTCATGAGTTA


AACAAAATTGACTTGTTTCTTGCTTTTAGTTACCAGTCTTAGGCTTAACTTGGAAACATATATTGAATACTAAATAAAATTTGCCCC


TGTAAATGAATTACATTTGTACTTAACATGGCTTATGTGCATAGTTTAGAGTACATTAAAGAATTTGATCATTTATAAGGTGGCTGA


CCATTAACTTGCATGTCTTAGTTATCTTTAACACTGTACAAGTTAGTAGTTTTATAATATCAGGATTTTACAACTTTATCTCTGCTA


AGTTTGAGCCTTAAAACTTTGAACTTTGTTGAAGAATTGATTGAAAATCCTTTAGCATTAAAACAAAACTTTAAGCCATAAGTGTAT


TCCATAAAAGGACTAGAAGTTTTACAAAACCATAAGTACAGTTCACATAGAGACCAGAAACCATTTTGGCTGTCGTTTGTTCCTTTT


CTCCTTTCATGATGCACCATTACAAAATATCAGTTTCTTGTAAGACTCTGTTTATCTAAGTAACTAAACTTAGAAAAATCAGTAAAG


ACAAAGAGGCTAGACAATAGGTCTAGTCGGTTAGTTAACCTGTGTAGACCTTAGGAATGTATAAACCTTATTTATCAAGCATATGTT


TTTTATTATTTAATGTTCTAGAAGCCTGATGTTGAGCAGTTAGCAAAGGCATGAGTGGTTAAATATACATCCCTAAAACAGTCCCTG


TTCACCTGAGTAGACTTTATAACCTTAGGAACTTATTACCGCATAAAAATTCATCCTAACCTGAATGTTTAGAAGCCCTGCTGTTGC


CAAGTGTGTTTGAAAGGGAGATACAATGATAAACAGAGGCCTCGGCAGGACTGAAACGTTGTATACTTGTTGCGTTATGCCACATGG


TCACCTTAACCAAGATGGTGGTAAAATTACATCGCATGTACACTTTTTGACCTTGGTAAAGATGAGCTGCCAGACATGTGGTTGCTA


TTTAAAACCATCTATTTTCTAGTAGACCTGTTTTTTAAACAAGAGTTAAATCTAAATTACATATACAAAATATTCTAAACAAGAGTT


GAGTCCCAAATATAGAATGTTGTAATAAGATTATACAGATATAGTTTTTTTTTAACTTTAAGCCCTTCTGTTACAAGTGTTAAGCTA


AATTTTGTTCAGGTTTTTAATCATACCCAATGAACTTACAAACCCTGAGATAGTTTACAGTAAGAGATTGGGGGGAGTGAGGCAGGG


GAGGAGAGAAATTGTAAGGATAAAGGTTGTTTATGATGGAAAGTAGAAAAAACCTTAGAGGTAAGAAACTTTTCGAAGTGTAGAGTA


AAGAAAGTTTAGATATAAGAGATTTGATGTTGTTTGTTTGTTATGCGGTGGTATAAGCTGTTACCATAGGAGAGAATTTAAAATCAA


GCATGCCACACTGACTGAGCAGTACTGAGGCCAAGGCATGCAGAGTAAAACAGCGAGGCTTTAATAAGATCCTTGAGTCTGAGGAGG


AGAAGAGAAAGGGTCCTATGAAGCCCAGGAGGGTTTAAGGAAGCTGAGGAGCTTCCAGGAGGCAGCTGAGAGACAAGGGATGGGATC


TCAGAAGCCCAGGAAGGCTTATGGAAGAAGATGCAGGACCACAGCTCCTTGAGGAAGGTGCAGAAGCTCTGAGAAGGAGCTGGGAGT


AGGTCGCTCCGGAGGAGAAGAGGCAAAGAAAGGGTCACAGGCCCAGGAGGACTTAAGGAAGCTGCAGGACAGCAGCTTCTAGGGAGA


GGCAAGGAAACACCAGGAAAGAGCTGAGAACAAACAGAACAGAAGAGGTTTAAGAATTTCAATCCTGTCTGTCCCCAAGTAAACTGA


GAGACTCCTCTGAGAGAAGTGTCCCAAATCACAGAGACCAGGCATTTTTTTTCCCCATGGGAATGGAGCCCCGTAGGGCAAGAGGAG


CAGCCTGGTGCACTGCTGTGGCTTTTGTAATAATAGTGGACAAGGCAGGCAGCTCCAGGGTGACACTTACCCAGCTGAGGAGGAGAG


AAGAAAGCAGCTGAAAAAGCAGGCTGAGGCAGGCTTTTGGAGAAAGGGAGAGGGTAGATGTCTTTAGTAGAGATATGTGGGTGTAAC


TGACCAAAGAGACAAAATGATATCCACGGATAGGGAGTAGTAGGTGCCAGGAGCCAGAGAGACACTGAGTAGCTATATTTGGGACAC


TTAGAGATAGAAATGATAACATTTACTCTCACTAAATGTGTATCTCATCTTCACCAGGTCTTCCAGGCTCCCTACTGGAACACCTCC


TGGACTTAAAGTCTGCCAAACAACTCACACACTAAGTTTGGCCCCAATACCTCTAAACAGCCACTTAGCAACACTTTTGAAGGAACT


TTTACAACTTTTGCCAGAGATCCGGAAATGGAAGGTTGCCTATGTGCAGGCTTCTCCATACCTTCACTCCAAACCTCTTCATTCCTC


CTGATCCCCAACTCATTTCTATCCTTGATCAGGCTAGCTTGCTTTCTCATTCTTGCTCCCCATTCCTTTGACTCTAAAAATACTCTC


CAGACTTTGTTTCAGACTTAACTCACTCTTGTTCTCGATCCCTGCCTGGTGCCCTACTCTACCACACACTCTCCCGTTTGCTCCAGC


TGGCAGCCTTGAACTTCTTAAACTCTACTTCCTAAAAAATAATTTATCTCTGATTTCTGCTTTTCCATTCTGATCTGCAACAGCTCT


AAGCCAGCTGTGGCCAAAGACAGGCCCGGTGGTTACTAGATCCCTCTGTGCACAAACACAAGAGGGAGTGCTTAAGTGGGTCCATGC


TGAGACATCTTTCCCTGAGGTACCATGATGGGTCTAGTTTAAAATAAACCATTTGGGGGCATGAGAAGGGGTTTGAGAAGAGAGTAG


AGGCAGAGAAAGAGAAAGGACAGAGAAGGACAGAAGGAGGAGAGCGAAAGGGAGAAGAGGCCGGCCAAGAGACAGAGAGGGGGAGGG


GGGAAAGAACAAAAGGAGAAAGAGGCCAGAGAGAAAGGCCAGAGAGAGAAAGGCCAGAGAGATGTGTGTGTGTGTGTCTGTGTGTGT


GTGTCTGTCTGTGTGTGTCTGTGTGTGTGTCTGTGTGTGTGTCTGTGTGTGTGTCTGTGTGTGTGCAAACAGTCCTTTCATAGCAAG


TGAGGATTGTACCTGGCTGTTGCTAGAGAACTGTTGGGCAGAGCCTTGAAGAAATGCTATCATTGACTGTTTTTACAGAGGACCAGG


GCTGGATTCCCAGCATTAATATGGCAGCTAACATCTGTAACTCCAAGATCCAACACTCCTACACAGACATACATCCAGGCAAAACAC


TAGAACAGATTAAAAACAACAACAACACAGATTAAAAATAAATAAATAAACAAATAGACATTATTTAAAAGAAGAGAGCCCATGAAA


TTGAGAGAGAAAGGTGGTGGTGGTGGGAAGTAGAAGTGGGATTGCAGACAGGACCGGACTTGATCCAAATGCATCATATGTATTTAA


CACAACATTAAAAAACAGACTTAAACCATCAAGTAAAGTGAATAAAGAAATGAAAGAAAAAAAACTGGCCATTGTTAGCCCTCAAAG


AAACCTGGGAAAATGGCTAACTGAGACCTATTTCACATATCAAACCCTGCTTCTGTCCACCAGTCTCCCTCAGTCCTTATTCACAAG


AACCTGCTGTAGAATTGTTCTAGGAAGGAACTTCTACATTGCTGTTCATCACCAAAGGAGGTCAGGTCAGGAACTCACAGAAGGCAG


GAACCTGGAGACAGAAGCTGATGCAGAGGCCATGGAGGGATGTTCCTTACTGGCTTACTTCCCCTGGTTTGCTCAGCTTGCTTTCTT


ATAGAACCCAAGACTACCAACCCAGGGATGGCACCACCCACAATGGGCCCTCCCACCCTGATCACTAATTGAGAAAATACCTTACTG


CTGGATCTCATGGAGGCATTTCCTCACCTAAAGCTCCTTTCTCTGAGATAACTCCAGCTTGTGTCAAGTTGACACACAAAACTAGCC


AGTACAATTACTTTAAAGATTTACAAAAGTAAAAAGTTAAGGACCACTACTTTAAAGATAGGTTTAGCTTTGTTTTTGCTACTATGA


TTAAGTTACAATGTAACCTCTTTGTTTGCTAGAACAAATAATTAAAAACAGATACAAATTGTCTAACTCAGATATGCTTTATAGATA


CTAGCTCTCAATCTTGTCAGAGATCTGCTAAATATTAAATGTTTAAGCTTGCTATGACAGACAGAGACTCCCAAATCCTAACAGTGA


CCCCCGCCCCAAGGTCTCCAAGAAGATATGGGCACAGCAGCAAAGGACTCTACCTGGCCTCTATCTCAGAGGTCTGATGACCACTGA


GAAAGACTGCTCCATTGCCTTTCCTGCTGCCAGGGCTCGGCCTGGTCTATGGACAGAGGACACCTGGAGAATTAAATGTCTCATATT


GCCTAAGACAAGATGAGTCATTTCTCCCATGTTCCTCCTCCACAGGAAAAGGCCTCTTATCTTCTGGGCCTAATGGCCAGACTGCCT


CTGCCCAAGTTTCGATGGAGACCACAGAGACCTGGGAGAACTGTTTAGGTAGTAGACTATAGACTAACCTCTGTCATTTTAATTAAT


ATATGATATCTAGACTATAATTAATTCTCCCCAGATTTCTGATTACATTGACAGCTAAACTAACTGCAGCTTGACAGCTAGAAAACA


ACTAACTCCTTACCCCAAGGTGATCCGCCAGCATATTAGCTCATTAGTCAATTTGTTAACTAGTTAAGACTACCAGATCTCCTATCA


AAAAGGTAGACAGGTTTGCCTTGCTCACAGGTTTCATGATAAAAGATACACAAATTTCCCATGTAACCTTTTTGCAGATATAACCTT


CTGCTACTTATCTAAAGAAAATCAGTTTACAGTGACTACTCCCCAGTGATTAGATTTGGTAAATAATTAAATAAAAGGCTTAAATAT


TTATAAAGCTCTAAATGGGGGTCTGGAAAGGTGTTTTGAGGTCAGTAATCATAAGATATAAAGGTTAGAGGACATACAAACTTAGGT


GGTGATGAAAATTGATTCAAAATACAAAGTGCTTCAGATTCCTGCCCCTTGCTATGCCACTGTTAAATTGAGAGTTCAAAGGTTCAA


AATGGAGTTCTGATAAATTAACTTAACTTTAATCAAACATCCCACTATACAGTTGAACTTTTGTAATCGCAGGTTCAAATTTCAAGT


TTCCTCTGATTGTCTTTTAACTATAGGCTTAAGGTGTTTCCCATGTTAACTCTATATGATCAGTTATCATATGCACGAGGTCAAGAT


TTTGAGTTTACTCTGATTGTCTCTTAAATGTAAACTTAAAAATGTTTCTCGTTGTGCTAAATTAATATACATCTACACAGAGGAAAA


TAACTGGCTTGCCCCTTCTACTCCACAAAAGGTTTTTGTCTTCCCTAAGACTGTTTGTGCTATTAAAAAATTATTATAAACTTATAA


CCTCCAGGAAACCCACTCAGATCTACCTCTCATGGACCAAGTAGGCTCTATCTAGATAAGTACACCTGCCAGTCAATAGCCTAAGTT


CCTACCTCTTACCTATTCCAGAGGGTGGGATTTCCCCCCTGTTCCCTGGGTTTAGGACTCCCCTCACCTCAACCTCCAAGGCCTAAG


TGTTTCAAGTGTACACCTAAGAAAAAGTTCTTCTCCCAAACCTACTTCCTACTTAACTTTATTCTGCCTCCAATGTGTGTGTGTGTG


TGTGTGTGTGTGTGTGTGTGTGTGTGTTTCAGCATCTTGCCAAGTCCAGGCATTTACTCAAAATCTACATCCAGAACAGCTCCAGAA


AAGAAACCCGAAGCTTCGTCAGTCTAATCTCACCGATGCTTCTACTGGGCCTGCACTTTCCTACCCACGGATGGCTCCACAGATCAT


GGACAGCAAGGAAATGGCCAACTCTCCTAAGACTGGGCCAACATCCCCATCTTCTCTTTGGTTTCCCAGAGCCACGCCACCCCAAAG


TCAGCAGGAAGTTGCAAAAGATCACAACGACCCTATTCCTGTTTTGTAACCACCCCCAGCCTGAAGCAGGCTGAGCCAGACCTTGAC


CTTGCTGCCACTAAGGAGATTACCTAGGGTGGAGCCTGCCTCTCTAGATCACTCTATTGTTCAGCCACTGCCACTCTTCTCCTTCAA


GACACTGCTACCTGCTGGGAGGCCACTGAGCTATTCCAGAGACTACACCCTATCCTGCACATCATCACCTGTAGCCTGTTCCAGGCT


CCAAGAATGAATTGGCGGCAATGGGCCTCCCCCCTACCCCCTTTATAAGTGCATTTGCCATTAAACATTTGCGCTTTGATCAGAAAC


CTTGACTTAGCTCCATTTTTCTCTCAACCTCCTAGTTCCCCTCTCTTTTCAGCTCCAGCTTGCCTCCCAGGTGAAACCCGGTCCATG


TGAGCCTCGGGTTGGCTTCCAACAGTCTGGCGTCCAAACAGGGACCTGAGGAATGGCAGAAAAATGCTGGAGGAAAGCTGCTTGGTA


TGGAGCTCCACGGGAAGAAAAAGAAAAGGATTGTATCGGGCACCGAAGCAACAGGTACACATGCTAGTGCTAGCTTAAAACTTCATT


TTTTAAAGTGTTGCTAGAGGTGCGGGAGGATATGGGCTAAGTTTGGAATCGGTGCTAACCCAACGCTGGTTTCCACTTAGGTTCAGC


AGCGAATTATTTGGAATTAGGAACTGATCAGGCGATTGTCTGCAGTTTTCAAAAACTGCTTTAGGTGAGAGAAAAAAGGGTTTAAAT


TAAATAATCAGGCAGATGTCCGCAGTCAGGAGCTGCATCAGGCGGCAGGAACAGGGTTTGTAATAATAAAATAATATAGAGGAAAAT


GGATTTTCAAACTCTCCCAGAGGCAGAGAAAAATTGGGGGGATGCCCTGCCCTTTTCTCTCTGGCCCCTACAGCAGAAGTTCTCTGC


CTTCTTTGTGTTGTCTAATATCTAGTCTAATGTCTGGTGCACCGGTCCTTTCACATGTCAATCCATGTGTGTTTGTGTCTAGTTGTC


TGAATGACTGAATGTTCTGTGTTTCATGTTGGAAAATAAAGATGGCTAAAACTTTATCTGCTGGTTCAGCAAAGCCAAGAGTGGCCA


CATGCTTTAGCCAAGGATCAGGTACAGCCGAGAAGCCTCTGCTGGAAAAGCTGCTCTCAAAGAAAGGGAGTCTGCAGCCTCTTAGTT


TGGGGGCAAAAAAGCTGATAGATGTTTTTATTCCTGGAGGGTTCTCTGCAATCGTGATTAATGTGTTTGGCAAATGGCAAAGTGCCT


TTTTTATCTTATAATTATAGCTAGAAAAATTGAAATTCTTTGATTGATCTAAATTCATAAGACTCATGTAGCCACTTCATTTGGTTT


TTTACTGGTCTTAGAGGTGTAATATGCTCTGCGTGTCTTCATCGTAGAGTATTAGCTTATAAGTTATTGGGTATGATCAAAAAGGTG


TAACACTGGTTACTAGAAAGTTAGCTTTAAATTGGTAACTCAGATTTGGAGTCTTTCCAAAACATGGCATAAGGCAGGCCAAGAGGC


TGGGTCTCTAAGGATACTTCTAGTTGAGATAATATTTAATGTGATTCTTATCCTAGAAAGAATTAAAGGTAAGATTTAAAGCAATGT


CTCTTTAATGAAGCATTAAGACTTGCACTGTCATGCATTCATAGGTATAAATTGGAAGCCAAATTTTGTAACGTGATAGTGAAGTTT


TGATGTTGATTCTAAGGTGATAAATTGCTTTGAAATTGGATTTTGCTTTCCCAAAGTTGTAGTTATAGTCTAATATTGCAAAAGAAA


CTTAAAAATTCTAAAATCTGTCCTCAGGGCAAGATGAACAAAGCTCAGACCAGCCTCTGCTGGGCTTGTGTGACTTTCTTTTGTCTT


GCAAACAGTGCCTAAGGAAGCTCTGGAAACTTGCCTCTCCTTGCCTTCAGGGAAAATTCCTTTTAGCTAAAAGAACACTGTTGCAGA


TCTATCCTGATGTTGTTCTAAATAAAGTTCAAATTCAAAGTTTATAAAAAGGTCAATCAGGCTGTAGAATTTATCAGAACATTGCGA


TTTGACTTGCCTACTTCATGTAAAGTTATTATAGATTTAAGAGTTTGTTTTTTCCTTTGCATCTGAAAGAACCTAGTAGGCAAACCC


CCACTCAGCTCCTGATTCAGCGTGCATGCAAGAATCACGAATAGAACACAACACCTTGATGTAACAACACGAGGTATTTTAATGGCG


GAGCTCTGGGTCGAAACGTATCTCACACAGGAGACAGTGGATTCGACCACAAGTCTTGGAAGCTAGGGGTTTTTATAGGAAAGGAGT


GGGGCTGGGGGAGGAATTGGTGCGGTTTCACATGATTGGTCTATTTAAACATCAGCAGCCAGTAACATTTAACTTAGGTCAGAGGGG


TGGGAGATAGGGAGGCGATGGGCCTGCCCGGGCATGTCCTGGTCTGTTCTGCTATGTTCTCAGCCCCAGGTTTCAAAGCTCACAAAC


AACTCTTTGGGCTATTTGACATACATTACATGAATCACAGGTCTCAAGTTTTATTTCCTTTCACATCCAGAAAATTGTAAAGAGTTT


GCTTCTAGTGAGCTTGTAATCATTGGAAAATTTTGCCTCTGGGTACGGCTAATATAACTTTACCTCATGTAAGAGAAATTCTTATTG


TCTTTGCTTCAATACAAGACGCTAAGAGTTTGAATCTTTCAGTATATATTGTTTCCTAAGTGGAAAGTATTTTATTAGCTAATGCTT


CTCAAGGGAAGTTTACTTTAAATCCTTGCTCTCACACAAGGAGCTTTTAAGTTCTGGGGAGTAGCTGTTGCTCCAGAAAAGATTCAG


AGGCAATATCTTTTGAATACTTAGGGTTTTGGTTATACTATAAAATTGTGGTACAGAAAATCTAAGAACAAAAAATTAATTTGCTTC


AAAGTTTTATTTTCAAAAGCTTCCAGGAGATGTTAATTGGCTAAGACCTCACCTTAAACTCACCACAGCAGAACTTAAGCCTTTGTT


AGGTGCTATTAAGTGAGACACAAAATAACTGGCAAAGAACAAAAGGCTTTGCAGAAAATAAAGAAAGCTTTTATAATTGTTATCAAT


TATAATCAATGGTAATTAAATATTAGCTGCCTATTTTAGTTATTGGTCATTAAATGTGCCCACAGCAATTCTTTGGCAAGAGAAAAC


ATTGTAAAGTCAGCTTTCTTCTCCTCCCGGCCGACCATTGGCCCACGTGGAGCCTGCCGGCTGCTGGCTGCTACAGGGCGGGGCCTG


GGGTACACAGCTTTCCCTGAGCAGTGGTGGTGTAGGAGGCCGCCAGAAAGCGGGTGCCTTTGTAGCGAACTCAGGGGAGGGCCTGAA


GCACCGGTTGCACGCGCCATTGCCCCTATGAGCATCCACTTGTTTCCATGGCCGTATTTTTCCTGCTAGGACTCGGGGTGCTCTGCC


GCCCTTGCTCGGGCTTCCTGGCCTACAACAGATTGGGCTGCTTCAGCCTCTATGGCCTGGGAGGAGGGCCGGAGGCAGGCAAGGCCG


AGGTGTCGTTCACCCCAAAGCACAGTTTTAACATCCTATTAAGGCTGCTGTGGTGCTAATAAATAATTGTAAGATAAATTTGTATAT


TTTAGAAAACCTATAACAAAAATTGTGTCTTAAGAACCTGACAAAGTGTTCCAAACAGCAATTAATTTGGTTATTACAGAATATTAA


TATTTGATCTATTGCATACCATCATTTTAAATTAAATTGTCAATCATTATCCCAAGGATAAGTTAAAAAATTGTTTTTATTCATGCT


TCTGTATCTTCTATAAATTCATGCATGCATGCATTCCAATTACTCTATTTAAAAACAGCCCTTCTATGGGAGAAAGGTATATGTGAA


TTGGATCACACGCTTATTCTTTTGAGTTTCCCCCTGCTTCAACACAGATAATTAAATTGTGTGCTCTAGATGGTGTTTTAAAATGTT


GAATAATCAAGCTTTAATTTGTATATTTATCAATATATATCTCAGAGCTTACAATTGCTTAAAATTGTTCATCCCTCAGATGCTATT


AATTCTCAAGTTTGCAATTGCTTATGCAACTCATAAGAAAAAATGCTGTTCTTTTAAGAAGACTGTTTTTGGACAGTTAAGAATTTG


TCCTGGGTTGCCTGGAAAAGACCCCCAGGATTTGCTTTTGTGTTATAGAGATTTACAAAAAGCTTTAGCTGATAAAGGATTACAGAT


AGCTCTTGAAAAGATACAAACTCCGGATCCTTATAATTATTTGGGTTTTAGACTTACTAATCAAGCTGTTTTTCCCCAGAAGATAGT


TATTTGCAGAGACAACTTAAGGACTTTGAATGATTTTCAAAAATTGTTAGGTGATATTAATTGGTTTCACCCCTATTTAAAGCTTAC


TACAGGGGAGTTGAAACCTTTATTTGATATTCTTAAAGGGAGTTCTGATCCTACTCCCCAAGATCTTTAGCCTCAGAAGGATTGCTG


GCCTTGCAACTAGTGGAAAAAGCTATTGAAGAACAATTTTTCACTTATATAGATTACTCTTTGCCTTTACTTCTGTTAATTTTTAAT


ATGATTCATATGCCTACAGGATTGTTATGCCAAAAGTCTCCTCTAATGTGGATACATTCGAGGATTTCTCCTAAACGTAATATCTTG


CCATATTATGAAGCAGTAGCTCAGATGATTATCCTTGGAAGGAAGTAGGCGCTAACTTATTTTGGCAAAGAGCCAGATCTTCTTGTT


CAGCCTTACAGCATAGGTCAAGACACTTGGGTAAAACAGCACAGTACAGATTTGTTGCTTGCTCAAATAGGGTTTAAAGGAACTGTA


GACAGCCACTACCCTCAAGATAAGTTGATAAATTTTTTTAAATGTATATGAGGTGATATTTCCTAATATGACCTCTTTACTACCCTT


ACACAATGCTGTTCTGGTGTTTACTGATGGCTCCTCTAAAGGGCAAGCTGGATATCTTATAAATAATCAACAGGTAATCATAAAGAC


TCCTGGCCTCTCAGCTCAATTAGCAGAATTAACAGCAGTACTGAATGTCTTTCAGTCTGTGAATGAGGCTTTTAATATCTTTACTGA


TAGTTTATATGTTGCACAATCGGTACTCTTATTGGAGACCTGTGGTACGTTTAACTTTAATACGCCAGCAGAATCCCTGTTTTCACA


ATTGCAAAACATCATTCTTGCCCGAAAATGCCCGTTCTATATTGGCCACATATGATCTCATTCTGGTCTTCCTGGACCTTTAGCTGA


AGGCAATGGTTGCATTGACAGAGCTCTAATAGGGAAGTTCTTAAATTCAAATCCTGTTGCTTTGGCCAAAGGTGATCATGAAAAATT


TCATCTCTCTAGCCATACCTTAAGGCTCCAACATAAGATCACCGAGGAGCAGGCAAGAATAATTGTAAAACAATGTCCTAAATATAT


TACATTATCTCCAGTGCCACATTTAGGAGTTAATCCACGAGGTCTTATGCCTAATCATAGTTGGCAAATGGATGTAACTCATTATGC


AGAATTTGGAAATTTTAAATATATACATGTTTGTATTGACACTTGTTCAGGATTTCTTTTTGCTTCTCTACTTACTGGAGAGGCCTC


TAAAAACGTAATTGATCATTGCCTACAAGCCTTTAATGCTATGGGATAGCCTAAATTTATTAAGACAGATAACGAGTCATCTTATTC


TAGCAAAAATTTTACTTCATTTTGTAAAGAATTTGGCATCAAACATAAAACTGGAATTACTTATAACCCCATGGGACAAGGAATAGT


TGAACATGCTCATCACACTTTTAAAAATTGGCTATATAATCTCGATCTTTATATATTCAAAACAGTAATGGTTTAAGATAATATTTT


GATATTTTTGGAGAATGTGTGTGTCAAATTGTAAAAAATTTGCTCTTGGTGTCCTTAGTTCCTACCTGTTTCCACATAATGGTGTTA


ATTCTTGAGGACCTATACTGAATAAATTGCTGCAAATGAATGCTCTTATTTCTGATTAATAAATAAATTATGCACATGTGACTATTA


ATAACTTTTCAAGCTTTCTAGTTGCAACCGCTCTTCAAGAGAAACAATTGAAAGTGTAATTAGTCACTCCCCTTGTTACATTAAAAC


TGACTTTAACAGTCAAGTATTTGAGATGTTTTGTCAACAATTTAATAATTCTCAAAGACAGGGTATTGTGGAACTTTAAAAACTCTT


CTTCTTAAAAAACAAAGAAAGGGGGAAATTATATCCCTGTGCACATTATTTAATATATCCCCATGCACATTATTTAAATCATACTTT


TATTTTAAGAATTTTGAAATTTGGATGTCAAAGAACTTAATAAATGCCTCATAGTATCTTAAAACCAGACATAATCATGTCTAGGTG


AGATGAAAAGGATCTACTTATTGGCATATGGCTTGATCCTGAACAGCTACCTTATTGGGAAAGGAAAAAGCATAGGTTCTCTTCACA


GAACGCTGCAGAAGCATGACGGCTAATTCATGTGACAAGCTGACAGGTGAGTTCCCTGAGTGCCCTGACTGTAGTGACAAGAAAGCT


GAATTGGGTATATGTTTTTGACCCACCTTTGCTTGCCATTTTCCCAGTGTGGACAGGCTAAGCTGCCTTGCTTCAAGCTGTTTAAAC


CTTATGGGACATAGAACATTAGAGACTGTGTAGTCTGACTTAGAAAGATTAGTCACAAGAAAGAGTTATAGTGATTCTTCTCCTTCC


CTCATTGTGACCAGTTATTCTAACTCAATCTTGAACTGGTCTAGTAATAATTCCAGTATTAGAGAATCCTAGGGAAGATAGCTAAAA


TCTTAATTACCTAGCAAAGTTAATTTGGAGCACAGCCTCCACTCTCAGAGAAGCTGCAACCTTTCTGCAATTCTCAAAGCCACCTCC


CCTACACCAGGAGCTCATAGTCTAAGCTTGATCGTTGCTAATTTCCAATTGAATGGAGTACCTGGACTTCCCCAAAGAAGCTTTTGT


ACTGTTGCTTTTCACTGTCTCAACTTTGTTTTTCAAGCAGGTCAGCCAATGCCCTTCAGCCTGACTGCAGCAGGTGTGCAGCCTTGC


CTCCAACAGCGCAGGTGGCAGTTATTAATCTTCATGAAGAACCATTCTAAGTGCATATTGTGGCTTTGGACTGAATTGGGAATAAGG


TGTGCTAATGAGTGCCAGACAGTCAAAGGTGGGCACCCACATCTTGGAACCATACCAATCTAAGACAGAGGTACATGCCAAAAGGCC


GTGGTTGTTGATAACACACCACAGAGCCATGTTTTGTGTGAAATATAACACAAACAGCTGCATGTAGCCTCCAAGATGGAATTGGAT


GGTTCGGGAAAATCGAAGATTTCCTAAGACAGGCGCAGCCGCCAGCCACCATAAGTCCCAGGCAGGACTAAAGAGCATAAATAAATT


TTATGCCTCAGTCCAGCTTTTTTTTAATATTAATAACGGGGGGGGGGGGATTGTAACTACCCCCAGCCTGAAGCAGGCTGAGCCAGA


CCTTGACCTTGCTGCCACTAAGGAGATTACCTAGGGTGGAGCCTTCCTCCCTAGATCACTCTATTGTTCAACCTCTGCCACTGTTCT


CCTTCAAGACACTGCTACCTGCTGGCAGGCCACTGAGCTATTCTGGAGACTACACCCTATCCTGCACGTCACCTGTAGCCTGTTCCA


GGCTCCAAGAATGAATTGGTGGCAATGGGCCTCCCCCTACCCCCTTTATAAGCGCATTTGACATTAAACATTTGGGCTTTGATCAGG


AACCTTGACTTAGCTCCACTTTTCTTTCGACCACCTAGTTCCCCTCTCTTTTCAGCCCCGGCTTGCGTCCATGTTAGCTGCGGGTCG


GCTTTCAACACTTTCACCATCACTGCCGCAGACCCTCTGGGTCCCTTTGTCTGTGTGGAACGAGTCTCTGGGCAGGTGGACAAGGCG


TCAGCGGGTGACAGACAGACCAACACGGGAGATTGTGTAGAATCTGAATGTATTCTCACAAAGTGAACACCAGTCTTATATAGTACA


GAAAATAAAAAAAGGTAGCAGGCAAAGAACATTGAAGTTACCTGATACAAAACAAAGGAATGACTTCAAAAGGATTTAGAGGAACCA


GGTAGATGTTTACAGTAAAGATAAAGCAGTCCTGCCTAGGGTCAGCTTAGTGACAGGTAAGGATTTCACACTCTAGTGCTATACCTT


TGAACCTTGTGAAAGCTAGCACCAGGGGGTTCTTCTCTTAGCAGGCCTCATGAATAATGCAACATCACAAACCCCTCCCCTCCCCAT


TTCCTAGGCCTTGCCAAACTCCCACATGAGTGTAACTTTTAAGTAACTGGAGAATCTCCATTTGTCAGGAGAATTCACCAACTTGCT


TCTAATATGCAATGCAGCCTATACTGAAGATTTCTATCTCAGTGGGATTCCCTGGCTCTATTATGGTATTCCCTTGTTTGGGTGAGA


TTTGCTACTGTCCTTAGTAAATATTTTGAAGACCAGCTCTTAGCTACTGGCTCCGTCCTTTGTAATGCTCAATTAGTAACTGAATAG


GTTAACTTCCTTACTGCATTCTTACAGGATTCTAAGCTCAGCTTCTGGGACCTGGAAACACTAGGGAGACTTAACTATATATAACAG


AATTTAATCTTAAAAGGCATTTATAATAAAATATGAAAAGAGAGCTCATAGTTCCATACACCAGACTAACGCGGGAATAGAGTATGA


GTATATGGGTAAATGAGAACGCCAAAGCTCCAGGAGGTGAGTTTCCGTAAAACTCTTTTCCTCGTTGAGTGCTTACAGACTTTCAGC


CTGTCAAACAGACTTGACCGGAGGGTGTGGCATATCGCCTCTTTCTAGTTTCTTAATTTTTTAAATTAAACCAAAATGGAGGAATGT


TAGCATTTCTTCTAAGCTCCACCCAACAGTTACCTAGGAACAGCCAGGTACCAGTCTGGCTTGCTATAAAAAGACTGTTTCTCTTTC


TCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTGAATGTTTCCAGGATCAAATTCTGAAGT


TTCCAGCAACCATAACAGTATTACACACTGAACAGTTTTTATGCATTGGGTTCATTTCTAAGGCCTGTAAGTAAAAACATATTTTCT


CCCTTAGCACTACACCTGTGTATATGACTGCAGCATATATGAAGACAATGAAAGGGAACAAAGATACTGTCCACACTAGGAAGATAA


CAGGTATTATGCAGATACAGATATATACACAGCACACACATACCTGCATGTAGACACACGTGTCTTCACAGTAATTCTATATGCAGA


TAGTGAGATGGCTCCCATCATACAGATGAGAAACAGAGGCCAGGGAAGCTGAGTGCTGTGGCCCTGGCATAGTGGTGGCAAGGCATA


CCCAGGGCAAGGCATGGTACCTCTGCCTCCCTACAATGTGTGGCAATAATCTAAGATCAAACAACTAACAGAATAGAAAGCAGCATC


CTTCCCTTGAGTGCCCTCAGCAGCATGGCAAGCTGCTGTTGGGTAGGCTGGTCAGGGAAAGGATGGAAGGCAGAGGGTGACCTCACT


ATACAGGACACAGAGTCCTCTAAGCAGCACCCACATCTTAATTCTCCATTTCTTTGTACAGTGGCCTCTGAACTCAGGGTCCCTACA


GATACAGTGAGTGTTCTGATGCCACAGGCGTCCCTTGTGGCCCTGCCAGCTCTGCCCTTACCCTGATGCTTCATCTTCCAGGTATCT


TGTCATTTACTCCCATGAAGCTGACAAGAATCACAGACTGTAGGCTCCAGAAGTCGGTTACCTCAGCACTCCATAGATGAATCCACA


GACCTCCCACCTCCTGCCTCAGCTGGTACACCCTTAGCATTCTCCTCAGGAGAGAGAGTGCTCTTTGGTGAGGCTTCGGTGCATCCT


CCACTCTCTGTACCAAGTGGCCAGGTCTCAGGGCCCTTCTGAGCTCCCACCAACCCCCAGGGATAGTCATATCTCCTGGCTTCCTCA


GTGACCTTCAGTTTTGATGGCTGTTGCTCTCCTAGATTAGGACCATTCAACTGTATCTGGAAGTCCTGTTCTAGGGGAACATGGTGT


CAGCCGGGTGGCCCTCTGTACTGCTCCACCAAATGGGAACACACACTCTGGACCTCGGACTCATGAGGAACTCCTTATGGCTCGGCT


GCATTTACTCTCTTCTGATTGTCTAAAAGTTAAGGTCAGCACCTGGTGTGAAAGTCAGGATCAGCAGCACCTAGGACTCCATAGTCC


ATGTTGAGCTGTAGAAAGTACTGTGCAAATGTAGGTAAACCATGAGGAAGAGAGCAATATGGAATCCTATACACAAGAAACCCAGAA


GAACCCTGCTCTTTCCCAAGTGAAATGTGAGAACATCTGGGCAGGAAAGACTGTCTGCCCAGAGTTAGGGCTTCAACTTTCCATGCG


CTCGTGATCACCCAAGGACGTGGTGGACATGCAGGTGCTCATCCCAAGTCTGGGTAGAGCCTGAGATTCTGCATCTCTAATAAGCTT


CCAGATGGTACTGGGATCTAATAAGCGTCCTTGTTGATTTTCTCAAAGAACCAGCTCCAGGTTTTGTTGATTCTTTGTATAGTTCTT


TTGTTTCTACTTGATTGATTTCAGCCCAGAGTTTGAATATTTCCTGCCACCTCTCCTCTTGGGTTTATTTGCTTCTTTTTGTTCTAG


AGCTTTCAAGCGTGCTGCTCCAGTTTCTTTTTGGAGGCACTCAGCTATGAGTTTTCCACTAAGCACTGCTTTCATTGTGTCCCATAA


ATTTGGGTACATTGTTCCTTCATTTTCATTAAATTCTAAAAAGTCTTTAATTTCTTCCTTTATTTCTTCCTTGACCAAGTTATCATT


GAGTGGGGCATTGTTCAGCTTCCATGTGTGTGTGGGCTTTCTGTTGTTTTTGTTGTTATTGATGACCAGCCTAAGTCTGTGGTGATC


TGATAGAATGCATGGGATTATTTCAATCTTCTTGTATCTTTTGAGGACTGTTTTGTGACCAATTATATGGTTAATTTTGGAGATGGT


ACCATGAGGCGCTGAGAAGAAAGTATATTCTTTTGTTTTAGGATAAAATGTTCTATAGATATCTGTTAAATCCCTTTGGTTCATAAC


TTCTGTTACTTTCACTGTGTCTCTGTTTAGTTTGTTCCCATGATCTGTCCATTGATGAGAGTAGGGTGTTGAAGTCTCCCACTATTA


TTGTGTGAGGTGCAATATGTCCTTTGAGCTTTAGTCAAGTTTCTTTTATGAATGTGAGTGCCCTTGCATTTGGAGCATAGATGTTCA


GAATTGAGAGTTCATCTTGGTAGATTTTTCCTTTGACCAGTAGGAAGTGTCCTTTCTTATCATTTTTTTTGATAACTTTTGGTTGAG


AGTTGATTTTATTCGATATTAGAATGGCTACTCCAGCTTGTTTCTTGGGACTATTTGCTTGGAAAAATGTTTTCCAACATTTTACTC


TGAGGTAGTGTCTGCCTTTTTCACTGAGGTGTGTTTCCTGTATGCAGCAAAGTGTTGGGTCCTGTTTATATATCCAGTCTGTTAGTC


TTTGTCTTTTGGGGGAAATTGAGTCCATTGATGTTAAGAGATATTAAGGAAAATAAGATTGTTACTTCCTGTTAATTTTATCGTTAG


AAGTGGAATTATGTTTATGTGACTATCTTCTTTTGGGTTTGTTGAAAGATTACTTTCTTGCTTTTTCTGTGGTGTAGTTTCCCTCCT


TGCGTTGGTGTTTTCCATCTATTATCCTTTGCAGGGCTGGATTTATGGAAAGATTATGTAAATTTGGTTTTGTCATGGAATATCTTG


GTTCCTCTGTCTATGGTAATTGAGAGTTTTGCTGGGTATAGTAGCCTGGACTGGCATTTGTGTTCTCTTAGGGTCTGTATGAGATCT


GCCCAGGATCTTCTACCTTTCATAGTCTCTGGTGAGAAGTCTGATGTAATTCTGATAGTTCTGCCTTTATTTGTTACTTGACCCTTT


TCCCTTACTCCTTTTAATCTTTCTTTGTTTAGTACATTTGGTATTTTGATTATTATATGACAGGAGGAATTTCTTTTCTGGTCCAGT


CTCTCTGGGGTTCTGTAGGGTTCTTGTATGCTCATCAGCATCTCTTTCTTTAGGTTAGGGAAGTTTTCTTCTATAATTTTGTTGAAG


ATATTTACTGGTCCTTTAAGTTGGGAATCTTCACTCTCTTCTATACTTATTATCCTTAGGTTTGGTCTTCTCTTTGTGTCCTGGATG


TTTGGGGTTAGGAGATTTTTGCTTTTTGCATTTTCTTTGACTGTTGTGACAATGTTTTCTAAGGTATCTTCTGTACCTGATATTCTC


TCTTCTATCTCTTGTATTCTGTTGATGATGCTTGCATGTATGACTCCTGATCTCTTTCATAGGTTTTCTAACTGCAGGATTGTCTCC


TTTTGTGATTTCTTTATTGTTTATATTTCTATTTTTTAGGTCTTGGATGGTTTGGTTCATTACTTTCGCTGGTTTGATTGTGTTTTC


CTATAATTCTTTAAGGGATTTTTCTGTCTCCTCTTTAAGGGCTTCTAGCTGTTTACCTGTGTTCTCCAGTATTTCTTTAAGGGAGTT


ATTTATGTCCTTCTTAAAGTCCTCTATCACCATCATGAGAAGTGATTTTTAGATCTGATCTTGCTTTTCTGGTGTGCCAGGACTTGC


TATAGTGGGAGAATTGGGATCTGATGATGCCAAGTAACCTTGGTTTCTGTTGCTTATGTTCTTACGCTTGCCTCGCACCATCTGATT


ATCTCTAGTGCTACCCTCCCTATCTGACTGGAGCCTGTCCTTCCTGTGATCCTGGGTGTGTCAGAGCTCCTGGGAGTCAAGCTGTCT


CTGGGACCCTGAGATCCTGGTGTGACCAAGCTCCTGGATCCTGGCATCCTGAGATCCTGTAGTCCTGAGCGTGTGAGTGCCTGGGAG


TGGATCTTCCTTTGGGTGTTGTGGAACTGGCTGTGGATTTTGCGCCCAAGGTCTGCTCAGGGCACTGGCCCAGATCTGAAGGTGAAT


TTTTGTTTCTTAACCCGTTCTGTCTGTCTGTGTTTTTTGATTGGAAAATTGAGGCCGTTGATATTAAAATTATTTATTTAAATATGT


GTGTTGATTATGGCCATTATGTTATTTGAGTTCTTGATGGTAGTTTGTTGGTTTTGTTTGTTTGTTTGTTTGTTTGTTTGTTTTAAT


TATGGGGCTTCATATATCTTTTCACTGCCTCTTAGCTTTGTTCATTCTTCTCATCCAAAAACAATGCTGTCTGTATTTTCCTTAGGT


TTGTTCTGTTGGATATGTTTTTTAGGCTATTTATATCACGGAAATTTTTCTTTCTCCTTCAATCATGGAAGATAGTTTTTCTGGGTG


TAGTATTCTAGGTTAGCATCATAGTCTTTTAGGACTTGGAATGCATTGCTCCAGCTTACTCTGATCTGTTTTCCTTTAAAATGACTT


ACATTTTTTTTCTTTTACTGCTTTCAGTACACTTTCTTTATTATATATATTTACTGTTCTAACTATGATATGCTTTTGGGAATTTTT


TTGTTCTGTCTATTTAGTGTTCCATGTGCTTCTTGTATTTGTATGGGTGTATTTCTTTCCACATTTGGGGAAGTTTTTCTTCTATGA


TCTTGTTGAAGATCTGGCCTATGCCATCAACTTGGGATTTTTCTCATCTATGTCTATAATTTGAAGGTTTGGCTTTTTCATGGTGTC


CTACATTTTCTTTGCGATATTTTCCTGTTCTGTTTTGTTTTGTTACCTTTTTATGTTTCTTGTTCATTTGGTCTAGATCCTCTACTT


TATTTTGGAGAACTAATATTCTATCTTCTGCTTGATTCATTTGACTTGTAAAGTTCTACTGTGAATTTCTACAGTAGAACTTTAGCT


ATTATCTTTTTCTTTTTTTATTTAATATTTTTTATTATTACATATTTTCCTCAATTACATTTAGAATGCTATCCCAAAAGTCCCCCA


TACCCTGCCCCCCACTTCCCTACCCACCCATTCCCATTTTTTGGCCCTGGTGTTCCCCTGTACTGGGGCATATAAAGTTTGCATGTC


CAATGGGCCTCTCTTTCCAGTGGTGGCTGACTAAGCCATCTTTTGATACATATGCAGCTAGAGTCAAGAGCTCCGGGGTACTGGTTA


GTTCATAATGTTGTTGCACCTACAGGGCTGCAGATCTCTTTAGCTCCTTGGATACTTTCTCTAGCTCCTCCATTGGGGGCCCTGTGC


TCCATCCAATAGCTGACTGTGAGCATCCACTTATGTGTTTGCTAGGCCCCGGCATAGTCTCACAAGAGACAGCTATATCAGGGTCCT


TTCAGCCAACGCTTGCTAGTGTATGCAATGGTGTCATCGTTTGGAGGCTAATTATGGGATGGATCCCTGGATATGGCAGTCTCTAGA


TGGTCCATCCTTTTGTCTCAGCTCCAAACTTTGTCTCTGTAACTCCTTCCATGGGTGATTGTTTCCAATTCTAAGAAGGGGCAAAGT


GTCCACACTTTGGTCTTCATTCTTCTTCAGTTTCATGTGTTTTGCAAATTGTATCTTTTTCAATTCTATCTTCATTTCAGCTTCAGT


CTTCCTCAATATTTCTATCTCCTGATTGAATTCTGTTCTCAAGCCTTGGATTATCTTTATCATTTCCATCAGCCTTATGCTTTCTTG


AAACCACCAGTTTGTGGTTTCTTGGACATCAGTCAAACAATTATTTTTCTTAAGCTCTTTGTTCTTGATTTCAGCAAGCTGGTTCTT


TGTTTTATCTTTAAACTCCTTGTGCTCTTTGAGGAAGTTTATAATGGTTCTTTCAAATTCTGTGTTCTGAGGTTCATCTAGGTAATT


CTCATTGTTAAACATTTCTACAAAACGGGTACATTTTAGAGAGAAGATGGTGGTTTGATTCTTCATACTGTTATTATTGCAATGAGT


AGAGCATGTGAACTTCCTTTGTTAGTTCAAGTTTCCTATGGACAGAAAATGTTGGGGTGGAAGGGAAGATGTGGGTGCAGGTTGGAT


CTAGATGTTAGAAATGGCTTAGTGGAATTGAAGTCAGGTAGACAGAGGGAACTGGGATGGAATAGAAGATGTGTTTCCTGTTCCAAT


CATGGAGTGATGGGTAGAAAGGTTAGATATGGCATGGTAGAGTCCTATAGTTTGGGGATATGTAGTGAGAGGATCCTGCCTAGGGAT


CTTTTACAGTGAAGGCAGGGTATGTTGGTGGGAAGGTTAAGAGATCAAGGCGAAATCCTCTGGACTGTGGAAAGGGTATAAATGGGA


GGTCAGGGATACACACTAGGCTAGACCCTTGAGGAAAACATGGGAAATCTGGATATTTGGGGAAGCCTCATCTTCACAAAGATGGGA


TATCTTTTGAGGTTGTAGAGTTGGCCCAACAAAGAACTGGGGACAGGGGCTTTGGGTAGGGCAGATTTCAGCAGAAACCTAGAGCTT


GGCTGTACTATAGACAGTTTAGTCAGAGTAGGCCAAGGCACAGAATGTGAGACCCAGGCTAGAGCCTGGAGGAGGACATGGAAAGTC


TGGGTGCCTAATGGGGTAGTGTGGAAAAGACTTAGAGTGGATCTATTCAGTTTCAGGTAGCACAAAATTTGATAGAAGCCTAGATGT


TAGCTACAGTGCAAGCAAGAGTCTCTAGTCTTCCATTTTCTTTTCCTTCCAAGCCCAATGCCCTGAAGACAACATTGTATGTAACTA


TAGTTTAAGACCAGAGGCTGGCCCCTGTTCAATGTACCAGGTTAAGCCACTTACCAAAGAAAGCAAAGAAAAGTAAGATGAGAGGCA


AGAGAATATTTTATCAAAACAGTTGTTTAGAGAGGCACAAAACACTGGAGCCCACCTTCATGGTCCTGGCATGAGTTTTAACATTAA


ATAGAGGAAGAATTGAGGCAGTGATGAGAAGCACATATAAATAAGCCATCTTGGTCCAAGAGTGTTCCAGTTACTCATCCTCTACAG


TCTGATTCAGCCATGTGGCCCAAAGAAGTCCTTCTTGCTAAGGGAGCAGTCTTGTTCCCCATGAGATGGTTGCTCCTACTTAGGCTA


TCTCATGATGGAATGATTTGTTTGTAGGTTCTGATGTGTCTGGAATACAAGATGAACACAGATTTAGAATCTTGATGAGGGTGTGGC


AGCATTCTTTGATTACACACATCTTTGTTTCTTTAGCCTTGAAGAGAACTGAGAGTATTATCATTTTTGAGACAGTTTTAAGCCTGC


CTTCTGACTGGTGATTCTCCAGCCTCAGCCTCCCATGTCTAGAATTATAGCAATGCATCACACGGCTGCTCAGACAGATGTTCCTTC


GGTAATTAGCATGCCCAAGTTAACTGTCCAGTTAAGCATAAAGTTTGAAGGAACGGGGTGGGGGGTGGGGAACAATGAAAACTGAAG


TCCCAAAAGCTAGACTTTCACTCAGCTCTGAGTCACCTTACAGGCCCCAGAGAGGAGTTGGTGCTTTTCATTAAGAGCAATGTCTAA


GAGCCTGTTATAGATTCCCTTTAATATATTTCACCTGCTAAAGAGCATCCAGAAATGGAATGTTCTCCATTCTGTCACAAAAGCTCC


CTATTTTAAATGACGCTGAAGAGCTCATTGATCATTCCACAGCCCTATTTCACAAACGTGCTCTATCCAGTCCACTAAGCTGCATGA


AACTCACTGGATGTTCATTGCTGGCTGGGGTTCTTTGTAATACGACAGTCAAAGCCTTCCTACCATTCAGCTCATGAGCTCTTACTA


TTTTGTTTCTTTTCTTTTTGAAAACTTCATACAAGAATACATTCTTGTGTGTTGAGCATTCATTCCCCCACCCCTACCCTCTGACTC


AGTGCTTCTTTCTCACCAGTCCCCTGATAGTTTCATTTCTCCTTTCACAACACACACACAGAGACACAGACACACACATACACACAT


TGTGGTTCAGTGACAGAATGCTAAACGAAACCAACCACATCATATTTGCATAGGATCTTTTAGTTCTAGAAACTGTTTGTTCTTTTA


TAAAAGAGGGTTTTCATTGAGTTTCCTGAATCTTGAGGCTGAGAGTCTTTTCACTGGGAGCTGGAAACTCCTCACATACAAGAGTCA


CATTTGTTCCTTTGAGCCTGTGTCTTACTCCACAATACATACTCTCCTGAACATTCCAAATTGGTGGTCACCTCCTCTGGTTTTTAG


GGTTTGCTAAGAACCATTATGAAATAATTCCATTTCTTCTAGGCTCTGCCCCACAGTTACCAGGCAACAGCCACGTATGCCTGACTC


ATTATAAAAGGGGCTACTTGCCCCCTCCTCACTCTCTTGCTCTCTTATCCTCTTCCCTCTCTGTCCCTTCTCTCCCCATTCCCCTCC


CCCATCTCTCCACATGTTCATGGCTGGCTTCTTCTCTTCTACTCCTCTATTCGCTCTCTCTCTCTCTCTCTCCCTCCCTCCCTCCCT


TCTCAACTCTCAACTCTCTCCTCTCTCTCAACTCCCCTCCCCATGCCCTAAATAAACTCTATACTATATCCATCGTGTGACTGGTCT


CTCAAGGTGACGGGATGCCTCAGCATGGGCCCACAGAGGCACCCCCTTCCCAGCACCATACTGTGCCTCTACCAAACATATCCCTGA


CTTCTTTTTCTTTACTTTACTTTTTTTTTTTTTTTTTTATGAAACACAACACCCAGGGCCAGGCAGCGTGTCAGAGAGGAGGAAGAA


TCAATACCCAGGAATGATAAGGAGGTTTTCTGCACACTGTTACTCTCATCCAACTTTTTCATATTTTATAGGAGAACAGGTGATAAA


ATGTCATACATAGATTTAAGACATGCCCAGGCCCTGAAAAGGCTTCTGCTTAGTGGCAATGAACCTAGAAAGGAGCCCCTGAGCCAG


AAGAGAAGTGTACACCAACAACTCTCCTTCCTCACTGGAGAAGCCCAGGCCAGTGCAGCCCTCTCCAGCTCAGACTCCAGAATCTAG


CTGACCCCTCTTTCACAGCACAGCTTCAAGACACTGTGACCTCCTGTGTTTCAGGCATGGATACCACAGTGTGAAATCCTCACTTCT


CTGCTCCAGGACAAGGTCTGACATCTGTTTCCATCCCTTTCCCCTTCAGCCTCAGTCTTTCCCTCTTGAGAAGACATAGGGCCTCAC


CCCTTTTGTAGCCTAGAGTGCCTGAGCTTGGATCCTCAGCCTCCTCTTCACTGTAAGCTAGTTGCCTCTCTCCCTTCATCCTGATTT


TGTAAATGTTAACAAATATTAAATGCTCTGAAGAAAGGCTAGAGAGATGGCTCAGTGGTTAAGGGCACTGACTGCTCTTCTAGAGGT


CCCGAGTTCAATTCCCAGCAACCACATGGTGGCTCACAACCATCTGCTTTGTAATCTGATGCCCCCTTCTGGCCTGCAGGCATGCAT


GCAGATAGAGGGCTAATAGACATAAAAATAATATCGAGGGATATTAGATCTTGTCACAAGCCTTTTCTGCATCTACCAAGTTGACCA


TGTGATTTATGTCCATGAGTCTATTTAATTTATAATATTTATTGATTTATTATATTCTGAACATCCCTGAATTTCTGGGATAAACTC


AACTTCATCGTGGTAATTGCCTTTCTGATGTATTCTTAAACTTGAGTTGCAAGTATTTTACTAATCTATTATTGTCTAATATTGTCA


GGGAAACTGGTCTGTCTGTAATTTTATTTTGGTGAATCTTTATCTTTTGATAGCAGAGTAATACCAACTTCATTATAAGAGTTTAAT


AATGTTTCTTCCTTTCCTAATTCCCTCTTTAGTTGGGAAATTTTTAATTTCTGTTTATTGTAGGTTATTTTCATTTGATTATAGGAA


TTTTTTCATTTCCTTCTTGATTTTTTTCATGGACCCATTTGTCATTCAATACTGCATTGCTTAATCCCCTGAGTTTGTACATGCTCC


AGGGTTTCTCTTGTTGTGGATTTGTAGCCTTATTCCCTAAATAGGATATTAAATATTAGAGCTCTTATATCCAGGCTATTCCCACCC


AAGAGAAGGAGTCCAGGAAGAGTTAGTTCTTCGTGAATTTGAAATTTTTATTGAGCCACATAGACCTGGCAGGGGACACATACTCTT


ATAACTACAAATCCCGAGGCAGTCTCAAGCTGAGTGAGCACAGGGTTTATAAAGGTAAAAAATAAAATAAAATAAAAATAAAATAAA


AACACAAGTTTGTTATCTCCCATTGACATAGCTATAATGGCTGTTAGCAAGCATGACAGGATGTGGACCTTTAATAAAAGCAGGGCA


CAGCTGTGTCTCCATAGTATTTCTGTTTCAGAGATGAGCAGAAAGCCTTATAGTTACAGAAGCAGAACAATGCAGGTTAGCAGAAGT


TCCTGTCAGTACCATACATGCCTGAGAGTCAGGCAGACCTCAGCTTTAACAATTACATCTCTCTCACCTCAGAGCAACCACGGCTGT


TTGATATTACCACTATGGTGCTGTACTACTACCCAATAATAACTATGGCCCCTTTGGCTGCAATAACTGTTGGGAGATGAACAACCA


AGGATAGTATGGAGTGAGACCATATCTTAGTTACTAAGATTAAGAGTTGGAGGAAGCTGGGCAGTGGTGGTGCACGCCTTTAATCTC


AGCTCTTAGGAGGCAGAGGCAGGCGGATTTCTGAGTTCAAGGCCAGCCTGGTCTACAGAGTGAGTTCCAGGACAGCCAGGGCTACAC


AGAGAAACCCTGTCTCGAAAAAACAAAAACAAAAACAAAAACAAAAACAAAAAACAAAAAAAAGGAAGAAACTCATTCCTTCATTTA


AAAAAAAAGAGTTGTAGAAAAATAAAAATTAAATATTAGACTGACATTGAAATGAGAAAAAAAGTGGTGGCTAATGTATCTAGGAGG


AGGAAGTCGAGATATTGTTAGTTAGGGTCCACAGATTGTAGAGACTGTTAGCACTATGGAAGGTTATAATTAAGAAATAAATAGCTA


AGGGGATAATAATGAGCAAAAGAGAAGATGTGGGAATAAAAGGAGTAATAGCTGGGGCTGGAGAGATGGCTCAGTGGTTAAGAGCAC


TGACTGTTCTTCTAGAGGTCCTGAGTTCAATCCCCAGCAACCACATGGTGGCTCACAACCATCTGTAATGAGATCTGATGCCCTCTT


CTGGTGTGTCCAAGTATAGCGACAGTGTACTCATATACGTAAAATAAATAAATCTTTTTAAAAGGGGGGCAGGGGTAATAGTTAAAC


TGAAGGATAAATAATGCCTTAGAGTAAATCATGCAGAAAACCACAAGCAACAGCTCTGACTGTAAGCTGAGCAATGTTCAACAGAGG


TAAAACCATCATGAGACCTGTCTGAGAAAGTGGAATTTAAGTATCAGGAAATAATCAATTAAAGACTATGTATGGGGCTAACTGTGG


GCACAGCTATGCGGACGGGAAGGGTAACGTGTCCAGACGCGTCTGGTTCTAGCAGTTGCTATGCCGTGCTGGACGGTGGGGAGTCAG


GTGAGGACCTGCAGTGTCTGAAGCTTCAGCGTCCTGGGGGTCTCTTCTGGGTCTTTTGTGCATCCACATTAATTTTAGAAATTTTCA


TCTAGGTCTATGAAGATATTATTGGAATATTTAGGAAGACTATATTAAATGTATGGGTGCTTTAAGTTGCATGGCTATTTTTTTTTT


ATTATTAATCCTGCCAATCTGAGAATGTGGGAAGTCTTTCCGTCATCTATCATCTTCATGTTCTTTGGTGCCTTACAATTTTCACTG


AGGAAACCTCTCACCTCCTCGCCTAGGTTTGTTCCTAGGCCTTTGTTTTTTAAGCAACTGTAAATGGGATTTCTTTTTCCTCCTAGT


TTCTTTCTCAGCAAGTTTGTCATTGGCATGCAGAAAAGCTAATAATTTTGTATGTGTTGGCTTTATTACCTCCTATTTTGCTGGAAG


TGTTTATTGGATCTAGCTGTTTCCTGATGAAATCTTAGGGTGTTGTTGTTGTTTTTGTTGTTTCCTTTGGTTAAAGGCCATGTCCTC


TGCAAATAGAGATGAGTTGACTTCTTGTTTCCTGTGTGTGTCCCTTTTATTTATTTCTTTTATTTTCTTGCTAAGATTTCAAACACT


ATATTGAACGAATTATTTATTTATTTATTTATTTATTTATTTAATAATATCCTTCCTTGTCTCTTTCCATATCTTAAAGGAAACTCT


CTAAGCTTTCTCATTTTGAACAATGATTGTTAGAGGTTGAGAGATTAACTCGGAAGCCAGGCAAACACAGACCCCGGATTCAGTCTC


CAGCTCCAAAGAGTAGTTGTAGTGATGATGATGGTGATGGTGATGCTGATGACAATATTAATATTGTCATATGTTTGTCATGTGTAT


GCTTATTAAGATAACATGCTTTTTGTATTCCTAGTTTTTCAGGATATTTGTCAGGAAGGAATGTTAAACTTTAAAACCTGTCCTACA


TCTATTGAAATGATCATGTGACTTCTGTCCTTTAAATATATTTATATGCCTAATTACTCTTACTGATTTACATGTGTAGAACCCACC


ATGAATTCCCTGCAGTGAACTACCTTGGTCATCATGCAAGATCTTCCTAATGTATTCTTGAATTAAATTGACAAGAATTTTATTCAG


AACTTTTGCATCTATGTTCATTGGGGAGTTTGGTGGCTACTTTTCTTGTGTGTGTGTCTGTGTGTCTGTTGTGTCTGTGTGCACATG


CGCACTCCTATCCAGTTTGGAGCATTAGGGTAATGCTGGCTTTACAGGATGCTTTGGGTACCACGCCTCCCTTTCTTATTCCATAGA


ACAGATTGAGAAGTATTCATGTAAGTCCGTCTTTAAAGGTTTAGTGTAATTCTGTAGTGACTCTGCCTGGCTTTCTTTGTTGGGAGA


TTGTTTCTATTAATGCTTGATCCTCAGTGATTGTTATGGGTCTGTTTAAGGTTTATTTCCCAATTGATTTAATTTTGATATGTTACA


TATGTCTAGGAATTATCTATTTTGAGATTTTCTAAGCTACTTTAGTATTATGTTCAAAGTTGCCTCTAAATATTCTCTGGGCTTCAC


TGGAGTCTGCAGTAACCTCCATTTTCCATCTCTAGTTTTATTAGGTTGGGTCTTCTCACTCTTTCCTTTCATTTGCCTCAAGGTTTA


TTAGTTGGGTGTTCTCAAAGAACCATTTTTTATAGATGCATTTGGTACCTTTATTAATTTTATATATTATTCTTTTATTCTCTGTTT


CATTAATTTCTGCCCTGATCTTTATTTTTTCTTGACATCTGCTAGTCTGGGGCTTGGATGTACATGTTTTTCTAGGACATTGAGGTG


CATCATTAGACACTGTTGGACAAGCTGGACGACAGCCTGAAAGCTATTCTAATACATCCCTTTCTGTAAATGATAGATAGATAGATA


GATAGATAGATAGATAGATAGATAGATGATAGATAAATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATCCGCT


CTGCTGCTCTCAGTGCAACATCTAAAAAAAGTCAGGGTTTTTTTCCAGGAAAAAAAAAAAAGCACTTAAAATCCATATGGAATTTCA


AAAGACCATTTGTGCTGCCTCAAGAAAGTATCTATTACTGAACAAATTATTGTTGCCTAGCAGTTTCCTCTGAATTGAAACATTCTT


CCAGGAGAGGGGAGGAAGACTGTGAGACTCAGAAGGTAAACAGCCTTCTTCGTGTGTCTAGGATAGCTGAAACCCACAAGATTTATG


AGAGGCCCTCTGCAGAGGTGCAGGGGCAATAAACATCTGCTGGGGAAGGAGACTGAGGGGCTGAAAGGAGATTCCTGGGAGTGTAGA


GCTGCCTGTAAGCTGTGCAGGGAGCCCCAGGGTGCAGCTTTCTAAGTCACCACCCACTTTGGGGTAGGGATTGTGCATCATGCAGAT


GCAAGTGACTCCTCACCCAAAGCTGCTGTCAGTGACCCCACTAAGAATTCGCTGGATCACCAAGTTGGATTCGGTGCAATTGCTTCT


TTGGTGTGTTATGGCTGCCTTTCTCAGTGCACAGACGTGTGATGTTCCTCTTGTTGAATAAGTCTTAAGCCCCATTAGAATGAACAA


AGGACAGACAGCGACATTTAAAAAGTGACAGAGACACATGGATACAGAAATGCTGGGGTCAGGTGGGTCTTGTGTACTCTAATGGAG


CCACTCCTACCTCTGCCGCAATCTGGAACCTTAGAATATGTGTTGTATACAGCACAGAGAGAGTGGTTAGCTAGTGTATATAAAAAT


AGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATGATCCTGTTTTTCCCACTCAGAC


CCTGCTCCCAGAACGACGACTCTGAGACTAGTTATTAATGCCTAGGCCACAAGCTTTGGCTCATTTCCCTACTAGCTTGTAACTTAT


TCAACCTATTCTAACCATCATGTCTTCCACATGGTTAGTTACCATTCCTCAGCTTCATAGGTTCAAGTCTAGGGCAAATCTCCTCTG


TATTCTATTCTCAGTTCAGCTACCTGCTGGTTTACCACAGTCTCCTCAGCGTTCCCAGGCAATTCTCTCAAGCCTCTCACTATTTCC


CAGAATCCTCTCCCTTCTGCCCAGTGTCCCACCTCCCATTTTCTGCCTCAGCGCATTGGCCAAGGCTTTTATATTGACAGGTGTTGC


TAGTCTGAAGGAAAGGCCATCCAGATACTGCCCCACCTGGGGCTTCATCCCATACACAGTCACCAAACACACACTATTGTGGATGCC


AAGAAGTGCTTGCTAACAGGAGCCCGATATAGCTGTCTCCTGAGAGGCTCTGCCAGAGCCTGACATATACAGAGGCGGATGCTCACA


GCCAACCATTGAACTGATCACGGGGTCCCCAATAGAGGAGTTTAAGAGAAAGGACTGAAGGAGCTGAAGGGGTTTGCAACCCCATAG


GAAGAACAACAGTATCAACCAACAAGACCCCCCTCCCCCAGAACTCCCAGGGACTAAACCACCAACCAAAGAGTTCACATGGAGGGA


CCCATGGCTCCAGCCACATATGTAGCAGAGGATGGCCTTGTAGGGCATCAATGGGAGAAGAGGCCCTTGGTCCTGTGAGGGCTCAAT


GCCCCAGTGTAAGGGAATGCAAGGGTGGGGAGGCAGGAGTGGGTAGGTGGGTGAGGGCACACCCTCATAGAAGCAGGAGGAAGGGAG


ATGGAATGGGGGGGTGTCTTCTGGGGGGAATTGGGAAAGGGGATAACATTTGAAATCTAAATAAATAAAATAGCCAATTAAAAAAAG


AGAGAGTCTCTCTACAAGCTAGTCTCGTTAGGGTAGGAGATCTCTGTAGGTAAGCAGTCTCTGGGCGTTTACAAGGAGTCTCTGAAT


ATAAACATTTGAGAGGAAGAAGATAGGGTCACTGGGTTTTGCACCTATGGCTCAATCGTTCATAAACACTCCTAGTTGAGCCAGAGG


AAGACGGTTTTAACAATCCAAAGCCTGACCCATGTCATCAACAGCCATACATTCAGCACTTCACTAACTCAAGGTTTCCTCTCCTCC


CTACAGAAAGGGGAGGAGGAAGGAGCTTAAAGGGAAGAGAAATAGAAAGTGTAAATACTGAAAGCAGAGAGGGGACTATTGGGGGAG


GTGGGGCTAGCAGGTGAGGGAGCGAGGCATGGAAGGGCAGTGGGCAGCGAATGAGAACAAAGTATAATAAGTTAATGCGTGAAAGTG


TCACAGCAAAACCCATTACTCTGTACACTGACCAAAATAATAATAACTTGAACAAATATTAACTGTTGGACCCTAGTCTCACTGGTA


GAAAACCATCCATGGAATATTGATTGCCTTGTTTATGCTCCCTCTTTAACTCCAATTCCACATTCTGATGTTGCCTACATAATTGCT


ACTCTCCTCAGCAGATTGCAAGCAGCCATGTCTTCTCAACCCTATTTAAAGTGACACTGACTAATTTCCCACAAGTCCTTGGACCTC


TCAGAGGGAACTATTAAGAGATGGTCTGCCACAGGTAGCATCTCTCCTCTCCATACCACTGTCTGCGTGATTATTGTAGCCTGTGGC


TGCATCTTACTTGCTTCTGGCTCTGGGGCAGCTTTTGGCCAACCACAGCCCTCTCCTTTTATACTCAGAGGCAGAGGATCAGAGAGT


TTTGTTGTGAGATAGTGTCTGCTAGTAATATCAGAAGCTATACTCACACAGTCTTACCCACGTGACTGCCCAAACATGCGCTGAACA


AGGACAATAACAGGCATACCAAAGTGGACAGGGAAAGCCCAGGAGGCCATAGCCCTACACAAAGGACTCAGACAACGAAGGAATGCT


GACTATAAGAGAAACAGTCTGCTCCAGGGAAGAACACAGCAATGGTTAGTCAATGCCAAGGAAAACATGCATACGAGTAACATTGTA


CAGACTGAGGAATATCTACGTATAGGCATATACATAACCTGCTTGTAATAGCAATGAAAAGAGGACATGAATTTGGAAGGAGGAGTA


TATGCTACTGTTTGAAAGGAGGAACAATAGAAAGAAATGTTGTAATTATGTTATAATCTCAAAATAAGAGCAATAACTTTAAAAAAA


ATTCTAATCATAACCCAAAGGATGAGGTAGGAATTGTAAATCCATCAATGTGCAGCATTGTTCCCACCTTTCTCTCAGGTGCAAGCC


TCTTGCTGAGTTCTCTCAGGTTCGAGCCTCTTGGTGCCCCATGGCAGAAGTAACTGCTTTACAGTTGACTCTTCAGAAGATAAAAGG


CCCAGTTTCTTGTGTTTTCCAGCTTCTCTGCTATAAATATCACCACCGTAGCTGATTGCAAACTATCAGCATTATAACTGAACACAG


AGTTTGGAAGCGACCACATAGATCTAGCTCTTAGCCTGTTCCAGCTGGCCCCGGCACATGGCAGCCAGCAAATGCTAATGTTTAAAT


GTGGAGAGTAGTTATTTTCTTTTAATTTTTGAGACTGTCTCACTGTGTAGCCCTGGCTGGTCTGGACCTCACTATGTAAACAAGGCT


GGCTTCAAACCCAAGTTCTGGGATTAAAGGTACCTGGCTTATAAGGTACACTCTTTGTATACCATGGACCCTAACTAACTGCCCCTA


TTTTTTAAAATATGTATTTTTTTTTAGAATTTCGCACATGGATTTAATGCATCTTCATTATATTCCCCTCTTTCCTGATCCACACCC


CCTCCCCCACCACCCCAACTCCATTTCCTCTTTTATTACACTCACTGAGTCCAGTTTGTACTGCATATACACTCACGGATGTGAGAC


CGTCCACTGAGGCCTGGTCATGCTACCGGAGTCCACACAGGATGCCTTAAAGAAAGCGGACCCTCCCTCCCCAGCAGCTCTCACCTC


TCAGCTAGGAGTGCAGGCTCAAGATCCCCTCCCTACTCTGTGCTGGATAGTTCACTGGCTTGGTCTCGTGCAGGTCTCGTGTAGCCA


CAATAGCTGCTATGTGTTCATGTATGCAGTAGTCCCTCCCGCTGTGTTCAGAAGACATTGCTTTCCTCTGCTCCTCCTTGACTGATG


GCTCTTACGATCTTTCTGCTCTCTCTTCTACAATGACTCTGGAGCCTTGGGGGTGGGAGTGGACGACGTCTCAGTTGCTGAACACCC


AACAGACACTTATCCCTGCACTTCAGTTGTGAGGTTCTGCATTAAGCACTGGTCACTGCATCGTGAAACTTCTCTGGTGAGGTTTAA


GAGATGCTCTGATCTATCGATATGGAGCTATGGATTTAGAGCCTGTCCCTATTTTATAGGAGGAAGTGGCCATCTGCTCTAAAGCAG


AAGGGAAAACATGCAAAGAGAGTACGTTGCTCTCCGGCACAGCAGCACCATTGTGGAAGTCACAAGAATAATTTTAAGTATGATTTC


TACCAGAAACTCTTTAACTTCCTTTCAATGGCCTTAAGAAAGAATTAGGAACTACTCATGTAGTCCCGCAGGGTGGGGCTGAGGTTA


GGGTTACAATATTATAATGAAAGACCTTTCTAACACAATGTTTTCTCCTTTGCTGTCCCACACGTTACCGATGTTCTCAAATATCTG


TCCCCTGAGTGTAATCTAAAGCCACTCGGGATCCAGATAAAGTAATCCATTTCCCACTCTTACTACTAAACTGTATAATCCTAAACA


GATCTGTGACCACCAATGATTCTGGCAAATGAAGGCTTCCCTGAAGATCTGCTGGGCAGATGAAGTAAACGGGTTGTAAAAGCAGCT


TCCACTTCCAGGAACAGATGTGCTGAGCCACAGGCATGCAATATTGCCACCTTGTGGCTTCTCACAGAATTGCCCAAAAGGCAAACA


TTCCTTGGAGGTCCAAAAGGAACCTTACTAGGGGTGTGGGGAGTGCAGTCTAGAGTTGTGATGAGATCCAGAGCTATGATTATGAGA


AGCCAGTCGGTATCACAGGAAGAGACTGGCCTCTACCAACCACCATAAAACTCATTTGGGGAGTTGTTGTTTTGTTTGGACAATTAT


CAGCTCTTTGGCCCCCAAAGACAAAATTATCTAAATATACATTTTACAGTTGAAAGGAGAAGATAACAGTTCCTACAGTTTGTTCAA


ACACTCGTGATTATCGGCTGCCCTTCATATTGTTCTTGCCCCTCTTTCCTATTCCAGATTCCCAAGAATAGAATGTGCCTGACTCCC


ACAGTACCCTATAGATCTGGCCAATCATCTCAGTTTTCAGTGGAGCCATGGAAATGCTCCCAATACCCTCCATCTCTTAGAAGAACA


ATCTCAGGTTCCAATCTCGTCCCCGGTGCTTCAGATCCAAACCTCCAAAATTTCACATTATTTAGTAACAGATTTGGTGGCACGCTC


CTGACAAACTCAAGTCAAGAACCCCCGAGGAAAATGGCAGACTAGAAGACGTTTCTACGCCACCCTTTGAATGAGAAGAGCCACAAT


AAGAAAAATAGACACTTCTGAAGAGAAAGAAAGAAGAAACGTTTTAAAATGCACCAAAATAGTGTTAAAATACCTGGAAAGTGGGGA


GGAAAGACAGGTAACGCATGAGAAACAGCCAACGTAAACACAGACCAGCAGCATGGCTGTGATGTGGACAGGGTGAACAGACTTCTC


ATAAGCTAAAGGAAGCTGCCCTGGTGAGAGAAAACTGGCCGTCCTGCCCTCAGAGCAAGTCCTCAGCCCTCACAAGCCTGAAAACCA


GTGGCAGCTTTTGTGAGACAACCATTCCTCCGGCACTGAAAGAGGAAGCACACCCAGCAGCTGCGTGCGCCTCAGAGCGGAAGTGAC


CCGGTTTGAATGAGAAGGTCTCCCACAGGCATGTGGATTTGAACTCTTGGACCCCAGATGCTAGCACATTTGGAGAGGTTATAGAAC


CGCTAAGGTATGGAACCTTGCTGGAGAAAGCGTGCCCCTGGAGATAGGCTTCGTTAAGAGTGTAGCCTGCTTCTAGTTTACCCTCAG


CTTTCTGTTTGAGGTTGAGGATTCAATCACCCCCGCTTCCTGTTCTGGCCCCTCAGCCTGCGGTGGACTCTGCCTTTGGAACCAGAA


GCCAGAATCGGCATGTTGTTCCTAAGTGGCTGCTGACTGGCCATGCCATTTTCCTCACAGCAACAGAAAAATGTCTGATCCAGACGT


TGGTACAAAAGAGTGGGTACGG





MOUSE mRNA SEQUENCE:mR27-007.1 (Seq ID No: 12)


CAGATTTCTCCTTGGAGCTGTGAGTGACTACCATTGCGAGCAAGAGCAAGAGGAAAGCACTACCTGTGAGCAGATGTCTGGTTCATT


CTCACCCTGTGTGGTGTTCACACAGATGTGGCTGACTCTACTGGTTCTGACTCCTGTCAATGGACAGCATGATTTTCTGGTGCTGCA


AGCTCCACCTGCTGTGTTTGAAGGAGACTCTGTGGTTCTGAGGTGCTACGCAAAGAAAGGCATAGAAGCAGAGACCCTGACATTTTA


CAAGGATGGTAAAGCTCTGACATTACATCATCAAAGTGAGCTCTCTATTCATCATGCAAATCTGAAGGACAACGGTCAATACAAATG


CACTTCGAAGAAGAAGTGGTCTTTTGGGTCCCTCTATACTTCCAATACGGTCGGAGTTCAAGTCCAAGAGTTGTTCCCACGGCCTGT


GCTGAGAGCCAGACCCTCCCATCCCATAGATGGAAGTCCAGTGACCCTGACGTGTCAGACCCAGCTCTCTGCACAGAAGTCAGATGC


CCGGCTCCAGTTCTGTTTCTTCAGAAACCTCCAGCTTCTGGGGTCAGGCTGCAGCCGCTCCTCAGAGTTTCACATTCCTGCCATATG


GACTGAAGAGTCAAGGAGATACCAGTGCAAGGCAGAAACAGTGAATTCCCAAGTTAGAAAACAAAGTACAGCGTTCATAATCCCAGT


GCAGAGAGCTTCTGCGAGATTCCAAACACACATCATCCCAGCCTCAAAGTTGGTGTTTGAAGGGCAGTTGCTGTTACTCAACTGCTC


AGTAAAAGGAGTCCCAGGACCCCTCAAATTCTCCTGGTATAAAAAGGACATGCTGAATGAAGAAACAAAGATTCTTAAGTCCTCCAA


CGCAGAATTCAAGATCTCCCAGGTGAACATCAGTGACGCAGGGGAGTATCACTGTGAAGCTACCAACAGCCGCCGAAGCTTTGTCAG


CAGGGCATTTCCCATCACCATAAAAGTCCCAGTATCTCAACCAGTTCTCACCCTAAGCACAGGCAAGACCCAGGCCCTTGAGGGAGA


CTTGATGACACTTCATTGTCAATCCCAGAGGGGCTCTCCATGTATCCTGTATGAATTCTTCTATGAGAATGTCTCCCTGGGGAATAG


CTCTATACTCTCTGGAGGAGGAGCATACTTCAATTTCTCTATGAGCACAGAGCGATCTGGAAACTACTACTGCACAGCAGACAATGG


CCTGGGAGCCCAGTGCAGTGAAGCTATAAGGATCTCTATCTTTGACATGACAAAGAACAGAAGTGTTCCTATGGCTGCCGGAATCAC


TGTGGGACTGCTCATCATGGCTGTTGGAGTGTTTCTGTTTTATTGCTGGTTCTCTAGAAAAGCAGGAGGAAAGCCTACCTCTGATGA


CTCCAGAAACCCTTCAGATTCAGAACCCCAGGAGCCCACCTATTACAACGTACCAGCCTGTATAGAACTGCAGCCAGTGTACAGCAA


TGAGCCTGAGGAAAACGTGATTTACACAGAAGTACGGAGAACTCAACCAAGACAGAAACATGCAGATCAGGAGTCTGAAAGCCCAAG


ATCAAGGTGCCAGATGGCTGAGAAAAAGTAGGATATGTCTCCTCCAAGATTCCCAAGAATAGAATGTGCCTGACTCCCACAGTACCC


TATAGATCTGGCCAATCATCTCAGTTTTCAGTGGAGCCATGGAAATGCTCCCAATACCCTCCATCTCTTAGAAGAACAATCTCAGGT


TCCAATCTCGTCCCCGGTGCTTCAGATCCAAACCTCCAAAATTTCACATTATTTAGTAACAGATTTGGTGGCACGCTCCTGACAAAC


TCAAGTCAAGAACCCCCGAGGAAAATGGCAGACTAGAAGACGTTTCTACGCCACCCTTTGAATGAGAAGAGCCACAATAAGAAAAAT


AGACACTTCTGAAGAGAAAGAAAGAAGAAACGTTTTAAAATGCACCAAAATAGTGTTAAAATACCTGGAAAGTGGGGAGGAAAGACA


GGTAACGCATGAGAAACAGCCAACGTAAACACAGACCAGCAGCATGGCTGTGATGTGGACAGGGTGAACAGACTTCTCATAAGCTAA


AGGAAGCTGCCCTGGTGAGAGAAAACTGGCCGTCCTGCCCTCAGAGCAAGTCCTCAGCCCTCACAAGCCTGAAAACCAGTGGCAGCT


TTTGTGAGACAACCATTCCTCCGGCACTGAAAGAGGAAGCACACCCAGCAGCTGCGTGCGCCTCAGAGCGGAAGTGACCCGGTTTGA


ATGAGAAGGTCTCCCACAGGCATGTGGATTTGAACTCTTGGACCCCAGATGCTAGCACATTTGGAGAGGTTATAGAACCGCTAAGGT


ATGGAACCTTGCTGGAGAAAGCGTGCCCCTGGAGATAGGCTTCGTTAAGAGTGTAGCCTGCTTCTAGTTTACCCTCAGCTTTCTGTT


TGAGGTTGAGGATTCAATCACCCCCGCTTCCTGTTCTGGCCCCTCAGCCTGCGGTGGACTCTGCCTTTGGAACCAGAAGCCAGAATC


GGCATGTTGTTCCTAAGTGGCTGCTGACTGGCCATGCCATTTTCCTCACAGCAACAGAAAAATGTCTGATCCAGACGTTGGTACAAA


AGAGTGGGTACGG





MOUSE PROTEIN SEQUENCE:mP27-007.1 (Seq ID No: 13)


MSGSFSPCVVFTQMWLTLLVVTPVNGQHDFLVLQAPPAVFEGDSVVLRCYAKKGIEAETLTFYKDGKALTLHHQSELSIHHANLKDN


GQYKCTSKKKWSFGSLYTSNTVGVQVQELFPRPVLRARPSHPIDGSPVTLTCQTQLSAQKSDARLQFCFFRNLQLLGSGCSRSSEFH


IPAIWTEESRRYQCKAETVNSQVRKQSTAFIIPVQRASARFQTHIIPASKLVFEGQLLLLNCSVKGVPGPLKFSWYKKDMLNEETKI


LKSSNAEFKISQVNISDAGEYHCEATNSRRSFVSRAFPITIKVPVSQPVLTLSTGKTQALEGDLMTLHCQSQRGSPCILYEFFYENV


SLGNSSILSGGGAYFNFSMSTERSGNYYCTADNGLGAQCSEAIRISIFDMTKNRSVPMAAGITVGLLIMAVGVFLFYCWFSRKAGGK


PTSDDSRNPSDSEPQEPTYYNVPACIELQPVYSNEPEENVIYTEVRRTQPRQKHADQESESPRSRCQMAEKK*





MOUSE PANTHER CLASSIFICATIONS


       FAMILY (SUBFAMILY)


              CARCINOEMBRYONIC ANTIGEN (FC RECEPTOR-LIKE PROTEIN)


       BIOLOGICAL PROCESS


              Biological process unclassified (2.99.00.00.00)


       MOLECULAR FUNCTIONS


              Cell adhesion molecule (1.05.00.00.00) > CAM family adhesion


molecule (1.05.01.00.00)





MOUSE GENE ONTOLOGY


       BIOLOGICAL PROCESS


              phagocytosis > phagocytosis, engulfment


       MOLECULAR FUNCTION


              GO molecular function > cell adhesion


       CELL COMPONENT


              cell > membrane fraction





MOUSE PROTEIN DOMAINS (INTERPRO SIGNATURES)


              IPR003598 (IGc2)


              IPR003599 (IG)


              IPR003006 (ig)





MOUSE mRNA SEQUENCE:mR27-007.2 (Seq ID No: 14)


CARGTTACACTCAACTGTTTTAGARGAGCAGTTCCCCAGATTTCTCCTTGGAGCTGTGAGTGACTACCATTGCGAGCAAGAGCAAGA


GGAAAGCACTACCTGTGAGCAGATGTCTGGTTCATTCTCACCCTGTGTGGTGTTCACACAGATGTGGCTGACTCTACTGGTTGTGAC


TCCTGTCAATGGACAGCATGAAGCTGCACAGCAGTCTGTGGTTTCCCTTCAGCCTCCATGGACCACTTTCTTTCGAGGAGAGGTCGT


CACACTGACTTGTTATAGATTCGGCTTCTCCGTACCCCAGAAAACAAAATGGTACCAGAAAAGAAAAACAGTGAAGCAAACCCCAGG


TGCTTTGGTAATTAAAGCACATACCTTAAAGGTCCATGAGTCCGGAGAGTATTGGTGCCAAGCCGACAGCTTACTTCCGAGCATGCA


CGTGAACGTAGAGTTTTCTGAAGATTTTCTGGTGCTGCAAGCTCCACCTGCTGTGTTTGAAGGAGACTCTGTGGTTCTGAGGTGCTA


CGCAAAGAAAGGCATAGAAGCAGAGACCCTGACATTTTACAAGGATGGTAAAGCTCTGACATTACATCATCAAAGTGAGCTCTCTAT


TCATCATGCAAATCTGAAGGACAACGGTCAATACAAATGCACTTCGAAGAAGAAGTGGTCTTTTGGGTCCCTCTATACTTCCAATAC


GGTCGGAGTTCAAGTCCAAGTCCCAGTATCTCAACCAGTTCTCACCCTAAGCACAGGCAAGACCCAGGCCCTTGAGGGAGACTTGAT


GACACTTCATTGTCAATCCCAGAGGGGCTCTCCATGTATCCTGTATGAATTCTTCTATGAGAATGTCTCCCTGGGGAATAGCTCTAT


ACTCTCTGGAGGAGGAGCATACTTCAATTTCTCTATGAGCACAGAGCGATCTGGAAACTACTACTGCACAGCAGACAATGGCCTGGG


AGCCCAGTGCAGTGAAGCTATAAGGATCTCTATCTTTG





MOUSE PROTEIN SEQUENCE:mP27-007.2 (Seq ID No: 15)


MSGSFSPCVVFTQMWLTLLVVTPVNGQHEAAQQSVVSLQPPWTTFFRGEVVTLTCYRFGFSVPQKTKWYQKRKTVKQTPGALVIKAM


TLKVHESGEYWCQADSLLPSMHVNVEFSEDFLVLQAPPAVFEGDSVVLRCYAKKGIEAETLTFYKDGKALTLHHQSELSIHHANLKD


NGQYKCTSKKKWSFGSLYTSNTVGVQVQVPVSQPVLTLSTGKTQALEGDLMTLHCQSQRGSPCILYEFFYENVSLGNSSILSGGGAY


FNFSMSTERSGNYYCTADNGLGAQCSEAIRISIFX





MOUSE PANTHER CLASSIFICATIONS


       FAMILY (SUBFAMILY)


              CARCINOEMBRYONIC ANTIGEN (gb def: immunoglobulin superfamily receptor


translocation associated 2 [homo sapiens])


       BIOLOGICAL PROCESS


              Biological process unclassified (2.99.00.00.00)


       MOLECULAR FUNCTIONS


              Cell adhesion molecule (1.05.00.00.00) > CAM family adhesion


molecule (1.05.01.00.00)





MOUSE GENE ONTOLOGY


       BIOLOGICAL PROCESS


              phagocytosis > phagocytosis, engulfment


       MOLECULAR FUNCTION


              GO molecular function > cell adhesion


       CELL COMPONENT


              cell > membrane fraction





MOUSE PROTEIN DOMAINS (INTERPRO SIGNATURES)


              IPR003598 (IGc2)


              IPR003599 (IG)


              IPR003006 (ig)





HUMAN GENOMIC SEQUENCE:hD27-007 (Seq ID No: 16)


AATTCACTAATGCATTCTGCTCTTTTTGAGAGCACAGCTTCTCAGATGTGCTCCTTGGAGCTGGTGTGCAGTGTCCTGACTGTAAGA


TCAAGTCCAAACCTGTTTTGGAATTGAGGAAACTTCTCTTTTGATCTCAGCCCTTGGTGGTCCAGGTCTTCATGCTGCTGTGGGTGA


TATTACTGGTCCTGGGTGAGTAAAAGGGCTCACCATGGGCCCTGGGTGGGATCGGGACAGCTTCTCTCTCCACCGCAGGCCTGGTCC


TTTCTTGGGGCTCAGCCCCTGCTGAGAGACTCTCTCCTACATTAGGAGACTGTATTTTTGAACTTTACTCTGTAGCTCAGGGCTTTC


TCTTGAGGCTGAAGAAAATGGCCACAGCTGGAAGGAATTTTCAATCTTACAGAGTAGGAAACCACAATAACCACAACAATTAAAATT


TCATTTATTTTTTTCTTTAAAAAGTACTTCTTAAAGTCCAGAGAATGTTTCATGTTTGTTTGTTCATATTGTCTTACTCATAGAAGA


GCCCACTCTCCTCTCTGCAGAGGAGATGTATTTATTCCTTGTATGACAAGGCCAGATCCTGGTCCCCAGCATAAGAGGCAAGGTTTC


TAACGGGAAAGACAGGTCTTTCTCTTGTACATAATTGCAAACCACTGCAGCAATTGGCTGATTAAGAACATGGGGTGGAGGAGGTCG


CAGAGGCGTAGGTGGACAAAGCAAGGATAAATCTAAAGCATATGACTTTCTCTTTGTCCCTGTGGGTGTACGTAAGTCTCTATCAAC


TCATATGTGCGAACTGGTTGATTTTTACTAAAGGTTAAATATTATAATTAAATATGTTTATTTATTTGTTCAGCAAATGTGTTTAGT


AATATCTATGCACAGGTGCTGAGCAATTAGAGTCCATAGGAGACACTACGTCTATGTTCTGGAAAGTCATGACATAGAAGGGCTCCC


AGCAAGGCCAATGTACTTTCAAGCAGCTATGCAACAAGCTCCCAGTTAAATAATTGTCCAGGCAAAGTTACCAATGAATGCTGTAGG


CAGATAATAAACTGTATTCAAAATAGCTAGTAAAGACTTCATGAAACTTAGAGGTGAGTAGGAGCTAGAGGAGCAGAAATGGAGCAG


GCGTGATATAAGAAAAGAGGACCTCACAGTTGGAAGGTGCATGGACTATAATTCCTGAAGTAGGAATACATCTCAGTGTGGCCCCAC


ACAATGTGGGTAATGGCCAGGTCCTGAGCATGAGAGGGCAAAGTTTATAACATGGGCTCTGGGGTCAAACAGGATCTAGGTTCAAAC


TTCATCTTGCCACCTACTGGCTACCAGATTCCTGGTCTACAAAATGCAGTTAATCCTAGTGCTTACCTCACAGGATTATTGACATGG


TTATATGAAATAACCTACGTAAATGCAGACCATATAGAAACCACTCACAAAAATATTAGCTTCATTTAAAACAATGCAAAGATGAAG


GAAGCCAAAATATTCAGGTGAATGGTGAATAATTTGTTGTTCTCAGTAAAACACTTAAGTTTGGATAAGTCTCCAATAGCCTCATGT


GGACAGGGATGATTTGTCTCTCACACACTCCTGGATTTCTATTGCCTTGCTCTGGAGTATGATTGGCATTCCAAAAATCTGTTGAAT


AAATAAATCAACCCATATGCAGAATACCTACTCAATTGATAAACCTGCCAGTTTTGTGTCCTCTCTCTCTTCATTACCCATTTCTCA


AATCTCTATCCTTCTATTCCTATATTATTAACCTAGTTCTTTAATTAATTCATTATACAACACAAATATATTTAGTGAATATTAAAG


GAATATCTTTTATATGCCATTCACCGTTATAGGTCCTGGAGGATATATGGTGAACATAAGGAAAGTCCTAGGTCTCATAGAGCTTGC


ATTATAGAGAAGGGAAAATAAACAAGCAGATAATGAAGATAATTTGGATAAATACTCTGACAAAAATTACACATTACCATCTCTTGG


GCTGAGCATCAGGTCTAAATAATCTGAGCATCAGTTGATTGTTTAAAAATTAGGCATGATGATAATGAGCCCTTGGATTCAATGATC


TCATGAAAAGAGTATAGCCTGGAGTCTGGTGCCCAAGGGAGGCTTAATTCATGTCCATTTCCTTGCCCTGCCTTCTAATCAGTCTCC


CTGCTTCATATTGTCCCATTAAATTCTGTCCACTGACAGAGTGCTCCATCAAAGTCTGAAATTCTAACCTTGTCAATCTCCTCCTTG


AAACCATTCCATGACTCCTTATCACTTTTATAATAAAATTAGAACCACTTACTCAGGCCCTGCATGCTTCTCTGGTCTTATTTCCCC


CAACACTCCCAGTTCCTGAGCACCAATGTCATTTCTCCACTTCTGTGCCCTTTCTACCTTGAAAGGTAGAAATCGCCTCTTACCACA


CACAAATGCTAACATCCACCTGCAGACTCATGTTCTCACTCACAGTTTTGTGAAGTATCATCTCCTTCAGGTACCTTCAAGGATCCA


CCCATCCTGTTCAACACATGTACACACAAACACACACTCTACACACACACATATATCCTACACACTGGGCTAGTGGCCCTTCTGCCC


CCAACATACCCCATGTGTATTTCTGTTATTGCACTTACACCCTGTGTTATATTATTTTAAATCGTGTTTCTGTTTTTCCACTAGTCA


ACTTCTTGATGGCAGATACCATTTTTAAAATTCATTGTAGAAGTCCAAATACCATGCCATATATATATGTATATATATGTATATTTA


TGTGTATATATATACATTTGATGAATAATTATTAGAGTTTTTAAATGAATTTTTTAAAGGGACAAGTAATACATGCATGGGTAAAAA


AGGGAATTATCTTCTTAAAACAAAATAATCATGGTTCTGTGCTCATCTCTGGCTCTTATTTTTTTGCAGCTCCTGTCAGTGGACAGT


TTGGTGAGTTCTCCTGTCTTTGGCTCTTCAGCGTCTCTGGTTAAGAGTGTCTCTTCCTAATAAATAGAAAACATTTGTGATGGCTGC


CTGAGATCTCCAATATCTCCTGTTTTCTTTCCTTTTTTTTATTATACTTTAAGTTTTAGGGTACATGTGCACAACGTGCAGGTTTGT


TATATATGTATACATGTGCCATGTTGGTGCGCTGCACCCACTAACTCGTCATTTAACATTAGGTATATCTCCTAATGCTATCCCTCC


CCCCTCCCCCCACCCCACAACAGGCCCTGGAGTGTGATGTTCCCCTTCCTGTGTCCAAGTGTTCTCATTGTTCAATTCCCACCTATG


AGTGAGAACATGCGGTGTTTGGTTTTTTGTCCTTGCAATAGTTTGCTGAGAATGACAGTTTCCAGCTTCATCCATGTCCCTACAAAG


GACATGAACTCATCATTTTTTATGGCTGCATAGTATTCCATGGTGTATATGTGCCACATTTCCTTGATCCAGTCTATCATTGTTGGA


CATTTGGGTTGGTTCCAAGTCTTTGCTACTGTGAATAGTGCCGCAGTAAACATACGTGTGCATGTGCCTTTATAGCAGCATGATTTG


TAGTCCATTGGTTATATACCTGGTAATGGGATGGCTGGGTCAAATGGTATTTCTGCTTCTAGATCCCTGAGGAATCGCCACACTGAC


TTCCACAATGGTTGAACTAGTTTACACTCCCACCAACAGTGTAAAAGTGTTCCTATTTCTCCACATCCTCTCCAGCACCTGTTGTTT


CCTGACTTTTTAATAATTGCCATTCTAACTGGTGTGATATGGTATCTCATTGTGGTTTTGATTTGCATTTCTCTGATGGCCAGTGAT


GATGAGCATTTTCTCATGTGTCTTTTGGCTGCATAAATGTCTTCTTTTGAGAAGTGTCTGTTCATATCCTTCACCCACTTTTTGATG


GGGTTGTTTGAATTTTTCTTGTAAATTTGTTTGAGTTCATTGTAGATTCTGGATATTAGCCCTTTGTCAAATGAGTAGATTGCAAAA


CTTTTCTCCCATTCTGTAGGTTGCCTGTTCACTCTGATGGTAGTTTCTTTTGCTGTGCAGAAGTTCTTTAGTTTAATTAGATCCCAT


TTGTCAATTTTGGCTTTTGTTGCCATTGCTTTTGGTGTTTTAGACATGAAGTCCTTGCCCATGCCTATGTCCTGAATGGTATTGCCT


AGGTTTTCTTAAAGACTTAAATGTTAGACCTAAAACAATATCTCCTGTTTTCTTGCTGAGGTCAGCAGGGATTTCAAAGTGATGCCT


GGTTTTTTGGCATCGTCCAAGGGCCAGGATAGCTTCATGGTCACCCTCTGACCCTCCCTGGGGGAAGGGGTGAATGCCCAAGCAGCT


CCCAGCCTTTGCTAAGCCCTGCATTTACTATTATTGCCAACAGACCCCATTTAGCCAGGCAGGACATCTTCAACTCCATGGCAAGTA


TATTGACTCAGGATAGGATCCTCTCAATCAGCGAGCCAGAAAAATACCCTGAAAATATCCCACTGTGCTGATGCCAGCAGGAATGCT


GCATTCTCTACACTTTGGAGTAAAATCCTCCAGGACATCCAATAACTGGGTCCTTACAAAAAAGAAAGGCACAGAAAGGGGAGATGG


GGAGAAGACAAGTTATCTGCATCCCACATTTAATTAGTTCTGGCTCTTACTGCCATTCCTTTGGCTCTGAGTGGATAATTGAGAACC


CATGAACAGCAACAACCCTCTACAACCCCTCTCCTTGTCCAAATCAGTGGCCCCAGCTGTAACTTTGTCCTGGTCACCTCTGGATGT


CAGTGAGTGACTTGTCCCTTCCTTGCTCTGCCACAATTAGCTGTGATGGGATTCTTCTGGGCACTTGAATCATCATCTACAAAATGA


AGATATTAGGTAAGTTGAGCTCTCAAGGTTTTCTCAGGGACAAATCTTAAGATAATATGATTTATTCTCTTAGGGAAAGTGCAAAAT


TGTGATTTTAACATAACCTTTGGAGTTTCTTATGAGTGTATGAACATGATGAAATGGCAGCGCAGCATTGATTTTCTCTGGGACCCA


CTTCCATGTAAGGCTACCTAACTGTGATATTTGATGGCGAATCCTGCTGGTGTCACCCTCCTGAAATCATTTTGCTCATTGCCATCC


CCTGGGCAATTTCTCCCTTGGGTGAGGTGAGGGCCACTGGCTGACAGGGAGCTTTGAGCTATCAGTGACCCTCCCAGAGGACCTCTT


TCAGATCCTCCAAACCCAGGTCCTTCAGGCTATGCAGCAGGAGGCCCTGAGGCTGGGTCTGCAGGCGCCTCCACCTCAGACTCCTTT


TCTCTTTCCTCTTCAGCAAGGACACCCAGGCCCATTATTTTCCTCCAGCCTCCATGGACCACAGTCTTCCAAGGAGAGAGAGTGACC


CTCACTTGCAAGGGATTTCGCTTCTACTCACCACAGAAAACAAAATGGTACCATCGGTACCTTGGGAAAGAAATACTAAGAGAAACC


CCAGACAATATCCTTGAGGTTCAGGAATCTGGAGAGTACAGATGCCAGGCCCAGGGCTCCCCTCTCAGTAGCCCTGTGCACTTGGAT


TTTTCTTCAGGTGAGAGAGCGTGAAAGACGCACCAACTTTAGAAATCAATTCAGCCCATGTTTCTCTCTAGCTGTTATTACTGTTTA


CCTCAGACCCTTCATGAGTGGACAATTTTATTTCACACTGTGGTAAGACAAGGAGAGAGTAAAAAGCTCAGAATACAACCAGACAGG


GAATGGGGTTAGCTGCTTAATTTTAAACATTAAAATAAATAGAATTTTTACTTGAGTGGATTAATGTCTCTAAACCTGTGGTTCTTA


AAGTTTGATTTGAGTCAGAAAGCCTGGGCAGCTTATCAACCATACAGATACTCAGGACCTACCTATGCTTATTCAATAGAAACCTGT


AGAAGTGGGGTCCAGCAATTTATATTTTTTACAAGCCTCTCCGGTACCAGAAAGTCTGAGGATTAATTTATTTGAGTGGTTCCTGAA


TCTATGTATAGCTTTTTGGTTTGGTTTGGTTTGGTTTGGTTTGGTTTGGTTTGGTTTGGTTTGGTTTTTTGAGATGGAGTCTCGCTC


TGTCACCCAGGCTGGAGTGCAGTGGCGTTATCTCGGCTCACTGCAACTTCTGTCTCCCGGGTTCAAGCAATTCTCCCACCTCGGTAT


CCCTAGTAAGTAGGACTACAAGAGCCCGCCATCACACCTGGCTAATTTTTGTATTCTTAGCAGAGATGGGATTTCCTCATGCTGCCC


AGGCTAATGTTGAACTCCTGGGCTCAAGTGATCTGCTCACCTAGGCCTCTCAAAGCGCTGGGATTACAGGTATGAGCCACTGCACCC


GGCCTCTATGTATAGTTTTAAGTCACATTATTTACTTGGAATAATAAGTGGCAGGAGAATTGTTCATACTTATGGGTAGATAATGCA


TAGGTAGATAAATATACAGAGAAAGAAAGATAAAGGAAGAGACATTTCCTTCCTTGTCCTAAAGCCACCTGTTTTGAAGTTGAAGTT


ACATCATTTTTTAATGTAGTGGAAGCAGTGTACTAGCAAGGAATAAACAAAAATGTTTATACTCTTTGACTTAACAATCCGTCTCTT


AAGAATTTGCCTACTGAAACAATCACAGATGTCCATCCCTGAAAATGGCAGACCTTAACATGGTTTAGAAAAAGAATACCTGGCCAG


GCGCGGTGGCTTACGCCTGTAATCCCAGCACTTTGGAAGGCCAAGGCGGGTGGATCACGAGGTCAGGAGATTGAGACCATCCTGGCT


AACACTATGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCTTGGTGGCGGGTGCCTGTAGTCCCAGCTACTCGGGAGG


CTGAGGCAGGAGAATGGCATGAACCCGGGAGATGGAGCTTGCAGTGAGCCGAGATAGCACCACTGCAGTCCTGCCTGGGTGAAAGAG


TGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAACTCATTAAAGAAATTACATTACTGCCAGTGAAGGAAAACCGCAAACATT


AAAAATCAGGTTCAATAATGATACTAATGATGTAGGAAAGTGTTCATAGCATAGTAAGTGAAAGGAAAGTTATCAAATCTACAAATA


TTAATATTATTCCATAAAAGAAATACGCATGAGCTCCAAGTACTTGAAAGTGGAAGAGAAAACTGGAAAAACATATGCCAAAACATG


GGTGGTGAGATGGTAGGTGATTTTACCTACATTTCTGCTTTTCAACTTTTCTTAAGGTGTATGTGTTCATTTTTAAATCAGAAAAAA


AGAAATGATAATTATTTTAAGAGTTCTTTTTCCCAACCCATTTTTTTAAAATAAAATCTACTTGGAAAAACAATGAAAAGAAAGGGG


AAACAGTAGGATGAACCAAATAACTCTATTGTGTTTCTCATAGCTTCGCTGATCCTGCAAGCTCCACTTTCTGTGTTTGAAGGAGAC


TCTGTGGTTCTGAGGTGCCGGGCAAAGGCGGAAGTAACACTGAATAATACTATTTACAAGAATGATAATGTCCTGGCATTCCTTAAT


AAAAGAACTGACTTCCATATTCCTCATGCATGTCTCAAGGACAATGGTGCATATCGCTGTACTGGATATAAGGAAAGTTGTTGCCCT


GTTTCTTCCAATACAGTCAAAATCCAAGTCCAAGGTAAAGCCTTCATTATTTTGTGAAGTGAGTTGGTCAAAAGGAGATTCCTTGGG


GTCATAGAGATAGAACAGGAGGAAAAGGGTGGACTGGAATACCACTAAACCACAGGACACATTCCTGCAAGGAGCAGAGGAAGTATA


GTAGTGTTTTGGGCTGAAGGAAGCTAGGGATCAATGGCATTCCTTTCTTTGCCTGCTTTTGGATGTGCTGCTGCTTGAAGTGTGCTT


TTCTCCAAAGCAGTTCCAGCCTCATTGCTCTGGGACTGTTGTGATTCTTCTCTCTAGAGCCATTTACACGTCCAGTGCTGAGAGCCA


GCTCCTTCCAGCCCATCAGCGGGAACCCAGTGACCCTGACCTGTGAGACCCAGCTCTCTCTAGAGAGGTCAGATGTCCCGCTCCGGT


TCCGCTTCTTCAGAGATGACCAGACCCTGGGATTAGGCTGGAGTCTCTCCCCGAATTTCCAGATTACTGCCATGTGGAGTAAAGATT


CAGGGTTCTACTGGTGTAAGGCAGCAACAATGCCTCACAGCGTCATATCTGACAGCCCGAGATCCTGGATACAGGTGCAGAGTAAGT


GTTGGTGGAACCTGAGATTTGCTGCAGAGAGGGCTGGAAAAGTGGGACAGGGCTGCATATCAGCGTGGGTCACCAGTCTCTGTAGAA


AAAACTCGTACCTGTGAGAATGGGAGTTGTGCAAGCAAAGAGACCTCTACTCTTGTGAACATCTTAGAAGAGCTTAGACCCAGCAAA


ATCCAAGAAAAGAAAGGTCTAATTTTTTTTCTTTCAATGCCATTAAATACAATTCTTTCTTTTCTCTCGCAGGGTTCTCTTCCCTGA


CATCATTTTTTTTTCTTCTAGGCCCATAGGGATAAGCCATGGGCTGTGGCATAGCTCTCTGACTCTGGGGTACAGAGGTATCTGTTG


TCCCAATTAACATTACTTATTGACAATAACCAAAGTGAAAATTTCTGTAGGATACAAAGACAGGTTGCAACATTATAGTTACTCCAA


ATATGTGACTCTGGAGGTTTACCATTCCCTAGTTATGAGTACAAATATGCACCCCAGATTACATCACCTCCCTTACTAGTATACAGC


ACCATCCTTCCTTCAAAGCTATTATGGTAGTTACAGTGATGAGGGAAAAACAGCTTCTGTAGAGCCCTGTGTCATCCCTCCACTCAT


GGCAAACTCCGGGCTCACTTATAAGGAGGCAAGGTGATCATCACCAGACTAGGAGTCAGGACACCAACTCTGGCCCTGGCTGGCCCT


GAAAACAGCCTACACAGGCAGGTCTCCTAGTCTCTCCTTGACTCAGTTTTCTCACCTGTAAATAAAGAAGGTCAGTCTGGGCCAAGG


GAGAGAGTAGGAGCAGAAGAAAAAGCTCTAGAAGACTATGCTAATCTTTAAGGAAAAACTAGCAATGGCAAATAAATCCCTGAGGCC


AATGCAAGTGAAGGAGAAATAAACAGGGATAGGAAAGAAGACTCAGAATAATTGGGCACTTCAGGTGCAACATTCCATAGTCATAGG


GCAGAAGGAAGGAGCAAGAAGCAGGTGCAGGTAAGGGTGTGTGGTTCTGATGGCAGCAAGTTAAGGGTGGAGACTGGAGACTGGGCA


TTTGCACTGGCCATGCCTTGTAATCTACAGTAAGAGGCAAAAGCAATTCTTGACTAATTTTTTCTCTTGCTCAGTCCCTGCATCTCA


TCCTGTCCTCACTCTCAGCCCTGAAAAGGCTCTGAATTTTGAGGGAACCAAGGTGACACTTCACTGTGAAACCCAGGAAGATTCTCT


GCGCACTTTGTACAGGTTTTATCATGAGGGTGTCCCCCTGAGGCACAAGTCAGTCCGCTGTGAAAGGGGAGCATCCATCAGCTTCTC


ACTGACTACAGAGAATTCAGGGAACTACTACTGCACAGCTGACAATGGCCTTGGCGCCAAGCCCAGTAAGGCTGTGAGCCTCTCAGT


CACTGGTAAGCCCTGCATTCCTGCCAATCACCCACCCCTGGCCAAGAGTCCTGCCTCACCCTGCCCTTCGGAAGTCAGCATATACCT


TCCAGTATCCTCAGTTTCTTTCTTGGGAAAACCTAATGTCCTCCTCCACTCTCCGGCTCACTGAACCAGCTGTCTGCCTCTTGAGTC


TCGTTGCATTGCAGTCTAGGTGCCCTCATACCCCTGCCTGATGGTGCAGTGGCTTTCTATCCCCTGGTTCCCAATTTCTGAGAAGCC


AAGTGCTTTTCTTGTGCTTTCCACTTGTCCTGTGGCTCCCCAGATGACTGATTTTCATTCACTATATTATTCTCAGTAGACACAGAC


TCAATTTCCAGGAGCACAGAGGTATCTCCTGTTCTGTTAATATCAGACATTAATCAATAAACCAAAGGCAAAGACATGTAAGACACA


AAGACAAGTCGCTGGATCATAGTTAACCCAGCATGTCCTTCTTGCTCAAGCCTTTTTTAGAGTTGATGGGCAGTAGGTAAGAAAGGC


ACGGGCAATGGTGGGCTGGGGGCAGGCCAGGAGATAGCTTCACCTCTACTTGCTTGGCTTAATGCCCTCAGAGCTATTCAGGTAGCT


GCCAAATAGTTATGACATCAAAAAGGTTTCCTTTGAGCTTTGGATCTCAGTTTCGAACCATCCATGCATGGCTGAATGCCAGGTCCA


ATGTTGAAGGAGACAGTGTGATTTGGGTCTATACTGGTGACAGAGAGTCCAGTCTTGGTTGGTCCTGGAAGCGGCATCAGTTTCCTT


TCCTGTAAAACAATAATACCAGCTTGGAAGACAAGCAAGAATCCAGTCCCTCCCACATGGATGTGTGAGATTATAAAGGAGAGGACC


AGGGAACCCAGCGGGAGACATCAAATGACGTAGAAAGAGAACAGTGTCCCTGACATTCAGTGGCCCAAAGAAAGTGGAGACAGTGAC


ATCATGATCAAACATGCTCAGAGATGTTTAAAGTCCTATTCAATGACTCACTTCTTCACCTAATAAATGCTGATTGCATATATTCCA


TGGACGAGACTGTACTGACATCTAAAGATGCATCTACGACTACACTAACCTGGCCTTCCCCACACAGTTCGTAGGGGCTAATAGCAA


ATGCAGTCAAGTAAGAGATTAAACATCAACCTGAGGATAGAAGCACCTGGTGGCTGCAGGAGCAGATGGAAAGGCATGCCAATCTGA


GTTGGGAAGTGAGAAAAAATTTCTTGGAAGAACTCATGTGTGAGTTGAGACCTGAGGATGAGTGGGAACATTTCAGGAGAAGAGGAT


TGTGGTGAGGGAGGGAAGGCATGTTCCAGGAACTGGAGGGGCAGTCGGTTCTTGACGACTGCAGCACAGACTGAACAGTGGAGAAAG


GTAGGATAAGGTTGGAGAGGAAGGTATGTTTAGACCATATTTAGAAGCAGAGTAAGGCCTTGGGCCATATTTTGCAGGGCAATCTGG


GCTCCATGAATGCTTTAAATCTTGGGGAAAACCACTCCAGCAGCACAGTGAGAAATGAGTCATAGAGCAGCCAGTTTGGGGGGCAGC


CAGGAGTAAAAGAGAGGGTTCATCAAGAGAGCGTCCAGTTGGAGCAAACCCCAGGCCAGTCCCAGTAGAGGAGTTGGGACTTGAGAA


GGAAGGACTCCGGTTGAAGCAAGAGGCACTGTGAGAGTGTGCCCCAATGTCACCAAGGGCATAATGTGTTCTAAGCAGAAGAGAGGG


AGCTGGTTTGGATAAGGCAAAGCTAAGAGATGATGACAGATAAAAACTGAGTCACATCCAGTGAATTTAGCCACAAAGTACTCTTTG


GCAGAAGACAGACTAGAATCAGAATACCTGGGTTTGACTGCTGCCTCTTCACTTACTAGCTGTGTGACTCACCCACTCGGGGCCTCA


GCATGTTCATCTGTGAAAGAGGGGCAACAATAATACCCACCTCAATGAATTGCTTAGATGATTAAATTAGAGTCTCTCTATATATCG


ATATTTACAAATTACATCCAACAAATATACAAACACCAGAACTTACTTAAAGACACTATAATGTCATTATAACAAACATCTATTTTA


TTATTTTTATCTTTATCATCATAATTATATTCACAAACATGAAAATCCACTTTAGTAGATTGTTGGGGATTAAAACCAAGTTGTAAT


GGACAAAACATCCATATGAGATATGAGATAAAGAAGTAGAGATGTTAAAGGTAGGTCACTTCTTCCAGAAGACTGACTACAGAAAGG


TGGACAAACCGACTGTGAGGAACTGCAAATGCAAATAGGGTTGTTTTTCTATTGTCTGATGGTTTTTTTTTTTTTTAAACATGGAGA


GGGTTAAACACATGCAAATGGTGTTTGCAAGAAGCCAGTAGAGGTAAAAACCTTTTATCTAGGACAGAGGCAGGTGAGCACAGGATG


AAAAGACAGAAGAAAATCCCCCCAGGCAGGCCAAGGAGGGCTCCTCCATAGCCTCAGGGCCCAGGTCAGAGTGAGGAGCTGATGCAC


GTAAGGGTGTGGTTCTGCTGGTGGAAAGACAAGGGAATTCTTTGAGAGCAACATCTCTGCACAACAGAGGCAGGTCCTACAACAAGG


GGAGCTGGGAGAGGAGAAAAGACAAGAGGTCTGGTGGAAAAGGAAAAGACAGGGAATGACTAGGATGGAGGACAGGAGAGCTGGTGA


GAGTAGCCTGGGAAGTGGCTGGGTCACCCTGCAGGTGGGTAGAGCCTGTGGACTGGAGACTGAACAACTGCACTGGTGAAACATTGA


ATCTGTGAACCAAAAACTATCTGAGACAGGTCTCAATCAATTTGGATAGTATATTTTGCCATGGCTAAAGACATGTGCCCCAGATTC


AGCTCCCTGCCTTCTCCAAAGATGATTTTGAGGGTTTCAATATTTAAAGGTGAAAGGGAAGATATGGAGAAAAAGGAAGAAATTTTT


TTAAAAGTATGTGTAAATAACAGACAAACAGTTGCATTCTTTTGAGTCTTTGATCAACCTTTAGCAGAATACACAATTTACATGTGA


GAGAGGGGCAGAGGAATAGTCACTTCTGTCTTCCTTTAGCCCAGTGAGTCTGCATTTTTAAGTCAGGGAAATAATCAGATATGCATT


TGTCTCCTGTAAGCAGCAATGACTTAAAGTTCTGTCTTTTGTCCTGCACTTGTGAAAATCAGCTATCAATTTACACTGTTAGGGTAA


AACAGAACCATTTAAAACAGAACCATTTTAGGGTAAAGATCTTGGGGCCCACAAATAATATTTCAGTGGACAAATTTTGAGGGAGGT


ATGTAGCTTTTAGAAAAGTCTTTGAAGTTATCTTATTAAGGAATAAAATAAAAAGCAGGTTTGCCTGAAATAGTTCCCAGCTTGACT


TTTCCCTTTGGCTTAGTGATTTGGGGTTCCCAAGATTTATTTTCCTTTTATGAAAACTACAGCAGGAGGCAGAAACAAATCTTGACT


AATTTTTTCTCTCTCTCAGTTCCCGTGTCTCATCCTGTCCTCAACCTCAGCTCTCCTGAGGACCTGATTTTTGAGGGAGCCAAGGTG


ACACTTCACTGTGAAGCCCAGAGAGGTTCACTCCCCATCCTGTACCAGTTTCATCATGAGGATGCTGCCCTGGAGCGTAGGTCGGCC


AACTCTGCAGGAGGAGTGGCCATCAGCTTCTCTCTGACTGCAGAGCATTCAGGGAACTACTACTGCACAGCTGACAATGGCTTTGGC


CCCCAGCGCAGTAAGGCGGTGAGCCTCTCCGTCACTGGTAAGCCCTGGGTTCCTGCCAATCACCCACCCCTGGCCAAGAGTCCTCTC


TTACCCAACCCTTCAGAAGTCAGCATGTACCTTCTAGTATCCTCTGTTTCTTTCTTGAAACAACCTAATATCCTCCTCCACTCTCTA


GCTCACTGAACCAGCTGTCTGCCCCTTGAGCCTCATCCCATTGCAGTCTGGGTGCCTTCCCACCCCTGCCTAATGATGCAGCAGCTT


TCTTTTCCCTGCTCCTCAAATTCTGAGCAGCCAATTGCTTTTCTTGTGCTCTCCACTTGTCCTGTAGATCTGCCAGATGCCTGATTT


TTGTTTACTAAATTATTCTTAGTAGATATAGACTCAGACTCAGTTCTCAGGAGCACAGAAATGTCCCCTGTCCAGTTAACATCAGAC


ATCAATGAATAACCAGATGCAAAGTCATGTAAGACACAAAGACAAGTCGCTGGATCACAGTTAACCCAACATGTCTCCCTTGCTCAA


GCCTTTTTTAGGGTTGATTGGGCAGTAGGTAAGAAAGGCACAGACAGCAGTGGGCTGAGGGCAGGTCAGGAGACAGCTTAACCTCTA


CTTGCTTGGCTTAATGCCCTCACGGCTACTCAGGTAACTGTCAAATAGTTATGACATCAAAAAGGTTTTCTTTGAGCTTTGGATCTC


AGTTTTGAACCATCCATGTGTGGCTAAATGGCCAGGTTCAATGTTGAAGGAGACAGTGTGATTTGGGCCTATACTGCAGACAGAGAG


TCCAGTCTTGGTTGGTCCCGGAAGCGGCCTCAGTTTCCTTTCCTGTAAAACAATAATACCACCTTGGAAGACAAGCAAGAATCCAGT


CCCTCCCACATGGATGTGTGTGATTATAAAGGAGAGGGCCAGGGAACCCAGGGGGAGATATCAAATGATGTAGAAAAAGAACAGTAC


TCCTAACATTCAGAGGCCCAAGGAAAGTGGAGACAGGGACATCATGATCAAACACACTCAGAGATGTTTAAAGTCCTATTAAATGAC


CCACTTCTTCACCTACTAAATGCTGATTCTATATATACACCTAGATGTAGTGACATCTAAGGATGCATCTAAGACTACACTAACCTG


GCCCTGCCCACACACTTCACAGGGGCTAATAGCAAATGCAGTCAAGTAATAGAGAAAACATCAACCTAAGTTTAGAAGTACCTGGTG


GCTGCAGGAGCAGATGAAAGGCATGCCAATCTGAGTTGGGAAGTGAGAAAACAATTCTTGGAATTTGAGATGATATCGGGGGAAATT


CACCCCCAATATTTTACATAGGTTCTTTTCTATTTTCCCTAAGTGTCAGCTGGTCTCAGAAATAAAGGGACAGAGTACAAAAGAGAA


CAATTTTAAAGCTGGGTGTCCGGGGGAGACATCACATGTCGGCAGGTTCCATGATGCCCCTTAAGCCATAAAACCAGCAAGTTTTTA


TTAGTGATTTTCAAAAGTGGAGGGAGTGTACTAATAGGGTGTGGCTCACAGAGATCACATGCTTCACAAAGTAATAAAATATCACAA


GGCAAATGGAGGCAGGGTGAGCTCACAGGACCACAGGACCGGGGCGAAATTAAAATTGCTAATGAAGCTTCGGGCACGCATTGTCAT


TGATAACATCTTATCAGGAGACAGGGTTTTGAGAGCAGACAACCAGTCTGACCAAAATTTATTAGGCAGGAATTTCCTCGTCCTAAT


AAGCCTGGGAGCACTACAGGAGACCAGAGCTTATTTCATCCCTCAGCAACGATCATAAAAGACAGCCATCCCCAAAGCGGCCATTTC


AGAGGCCTCCCCTTAGGGACATATTCTCTTTCTCAGGGATGTTCCTTGCTGAGAAAAAGAATTCAGTGATATCTCTCCTATTTGATT


TAGAAAGAAGAAAAATATGACTCTGTTCCACCCAGCTCACAGGCAGCCAGAGTTTAAGGTTATCTCCCTTGTTCCCTGAACATTGCT


GTTATCCTGTTCTTTTTTCAAGGTGCCCAGATTTCATATTGTTTAAACAATTTGTGCAGTTAACACAATTATCACAGGGTCCTGAGG


TGACATTCATCCTCAGCTTACAAAAATGATGGGATTAAGAGATTAAAGTAAAGACAGGCATAGGAAATCACAAGGGTATTGACTGTG


GAAGTGATAAGTGTCCATGAAATCTTCACAATTTATGTTCAGAGATTGCAGTAAAGACAGGCATAAGAAATTATAAAAGTATTAATT


TGGGGAACTAATAAATGTCCATGAAATCTTCAAAATTTATGTTCTTCTGCCATGGCTTCAGTTGGTCCCTCCATTCGGGGTCCCTGA


CTTCCCGCAACAAGATGAGACCTGATGGAGAAGAGGATTGTGGTGAGGGAGGGAGGACACTTTCAAGGAACTGGAGAGTGGTCAGTT


CTTGATGACTGAACCATAGACAGAACAGTGGAGAACCACAAGATAAGGTTGGGGAAGACAACATCATTAGAACCTACTTAGAAGCAG


AGTAAGGGCTTGGGCCATATTCTGCAGGGCAATCTGGGCTCCATGAAGGTTTTAAATGTTGGCGAAAACCACTCCAGCAGTACAGTG


GGGATCAGGTCATAGAGCAACCTGTTTGAGGAGCAGCCAGGCGTGAAGGAGGGAGCCCAACAAGGGAGTGTCCAGTTGGACAGAACC


CCCAGTCTAGTCCCAGTAGAGGAAATGGGACATGAGAAGGAAGGACTCTGGCCAAGGGAAAAGGCACTCACTGTGAGAGTGTGCCCC


ACTGTCACCAAGGGTAGAACATGTTCTAAGCAGATGATAGTGAGCCAGTTTGGATAAGGCAAAGCTAAGAGATGATGAAAGATAAAA


ACTGAGTCATGGCCAGGAGAGGTGGCTCATGCCTGTAATTCCAGCACTTTGGGAGGCTGAGGCAGGTGGATCACCTGAGGTCAGGAG


TTTGAGACCAGCCTGGCCAACATAGTGAAATCCTGTGTCTACTAAAAATACAAAAATTAGCCAGGTGTGGTGGCGGTCGCCTGTAAC


GCCAGCTACTCAGGAGGCTGATGCAGGAGAATTGCTTGAATTCGGGAGGCAAAGTTTGCAGTGAGCTGAGATCATGCCACTGAATTC


CAGGCTGGGTGACACAGTGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAACTGAGTCACATCCAGTGAATTTAGCCACAAA


GTACCCTTTGGCAGAAGAACACAGACTAGAACCAGAATACCTGGGTTTGACTGCTGCCTCTTCACTTACTAGCTGTGTGACTCAACC


ACTCGGGGCCTCAGTATTTTCATCTGTGACATAGGGACAACAATAATACCTACCTCATTGAATTGTTTTGATGATTAACTTAGTGTC


TTTATACATATAGATATTCACAAATTACATCTGACAAATATACACACACCAGAACTTAAAGGCACTATAATCTCATTATAACAAATA


TCTTTTTTATATTTATCATTATCATCATTACTACATTCATAAACATGAAAAATCAGCTTTAGTAGATTATTGGGGGTAAAAACTGAG


TTGTAATGGACAGAATATGCATATGAGATATGAGATAAAGAAGTAGAGATGATAAATGTAGGTCACTTCTTCCAGAAGTCTGTCCAC


AGAAAAGTGGAGGAACCAACTGTGAGGAACTTCAAATACAAATAAAGTTGTTTTTGAATTGTCTGATAGTTTTTCTTATATGGAGAT


AGTTAAACACACCAAAATGTAGTTTGGAAGAAGCCAAAAGAGGTAAGGACTTTATGTCTAGGACAGAGGCAGATGTGCACAAGGTCA


AGAGACATAGGAAAATCCCCCTTGGGCAGGCCAGGCATGGCTCTTCCATGGTTGCAGGGAAGCCTGCATGGTTGCAGGAAGAAGTGA


GGAGCGGTGCAAGTGAGTCTGGTGGTGGCAAGACAAGGAATTTTTTCCTTGAAAGCATCATCTCCTCTGCAAAAAGGAGGCAGGTCA


CACTACAAGAGGAGCCATGAGAGAAGAAGAGAGTATTGGTCTCCTGGAAAGATGAACAGATAGGGAAAGACCAGCATGGAGGGCTGG


TCACAGAAACCTGAGAAGTTGCTTGGCTGCCCTCCAGGTAGGTGAAGTCTAGAGATCCTGTACTGGAGACTGGGCATCTGCACTGGC


CAAGTGTTGAAATCTACAGTAAGAGGCAAAAGCAACTCTTGATTCAATCTTTCTCTTCCTCAGTCCCTGTGTCTCATCCTGTCCTCA


CCCTCAGCTCTGCTGAGGCCCTGACTTTTGAAGGAGCCACTGTGACACTTCACTGTGAAGTCCAGAGAGGTTCCCCACAAATCCTAT


ACCAGTTTTATCATGAGGACATGCCCCTGTGGAGCAGCTCAACACCCTCTGTGGGAAGAGTGTCCTTCAGCTTCTCTCTGACTGAAG


GACATTCAGGGAATTACTACTGCACAGCTGACAATGGCTTTGGTCCCCAGCGCAGTGAAGTGGTGAGCCTTTTTGTCACTGGTAAGT


GCTGGGTTCTTGCCAGTCACCCACCCCTGGCTGAGTTCTCTCTCACCCATTCCTTTAAAAATCTGTTTGCACTGTCCAGTTTCCTCC


CCTAATCAACTTAATCCCCTTCTTGGCTTCCTCCTCAACTAACTAGCTGGGGTTTTCCGTACTCATAAGTCCTGGCTCAGCCAGACC


CCTAAAACAGCTCAGTAGATTCCCCAGCTTTTACCAAATGAATTTATTTATTGTATTTTCTCCTCATTCCTTGTATGTTCCAACAGT


ACGCCAATTTTTCTTGATGCACGGAGCGTGTCCTACTTCTCTACTGACATTTACATATTAACTTAGCTACAAGCACAGTCTTATAGA


TAAATATTGGTCAAGACCTTAAATTCTCCAAAGGATTTCCAATCTTATGGTAGATTTGGAGAAAGCTGCTGGTGAACAAAGGGGGAA


ATGGCTCCCTAGGAACCAACTCCTCAAACTTCTGGAGTTTTTATGATCCCTTGTTTTCTAACCTGCTAAAATCAGTATCATTTTATT


GTATTATTTTAAAAAAACTATTGTTGAAGTATGACATACATTCAAGAAACGTGTGCAAATTGTATGTGTACGATTTGGTGTCTTTTT


AGGAGCTAAGTTGCTTCTCTTTTTACTTGAATCTTTGTTTATAGAAACTGGGGGAAAGTTTACTTTCTTTTCAGAGAAGCCAAATGG


TATGATAGAAAAATCTTGAGCCTGATGTGTCAGACATGCCCCTAGCATAACTTGTTGAGTAAAGAGGTTATTTTTAAAATGTGAATG


TTCTGAGACTACTCCAAAGTCAGAGCCAAATCTACTAGGAAGCTTCTAGACTTCACTCATTCTGCATCCCATTACTATCTTTTTATC


CATGTTTTACTTTCTTCTCATATTCAGCAGCATCTTAAGCCTCTTTATTTTCTGTTTCTTGACTGTCACCCTTAATGCCAGTAGAAT


GTAAGCTTCATGAGAACAGAACTGCATCCATCTTGGTCTTCACAACATCCCTGTGCCTACTCAGTGTTTGGCACACAGTAGGTCCTC


AGTCAACATTTGTAATTTAGTGGACAGATGATATGACAAGATGATAAGAGGGGATTTAAAAAAATCATCTAGCAAAGCCCAAGAGGA


AAAAAAACAAAGCTATTTTAGAAATGAAATACCAATTTGAAGCAGTAAGAATAGATTGGATATCTTTGAAAACCATTAATTGAATGA


AGAACCAATTTGAGAAAACAATACAGAATGCAAAGTAGAAAGATACAGAAATAAAGGCAAAAATTATAATATGGAAATCAGACAATG


GATTTGTCTGTATCCAGTTATGTGGATAATTAAAATGGAGACCCTCAGAAAATTGAACCGAAGAGTAAAATGAAACTCAAAAATGTA


GTAGAAATTGTTGGGAAGTAAAGAAAACTTGAATATGTAGATCAGAACATATATGTTGATGACGTTATTGACTTTGAGGTTAAAAAT


ATATATATGTGCCTATGATTATGGGGAAAAAAGCAGTCGTCTCAGAAAGAAAAACATCAAGTTAGTCTTAGACTTTGCAGTGCACTC


AGTACCAAAGAGAGAGGAGGTCCAGACTTGGACCTGCGAGGGAAGAATAATAACCGAAAATTTTATATCAATTCAAAAAGACATTGT


CAAAAATACAGGGATTCAGGAAACTGAGAATGCACTAAGCCTTCTGGAAAAAACACCTAATGACAAAATCTAGCCCAACAAGATGTA


AATGAATATAAAGGACTCATAATGAGGAAACCGCATTATGACTGGCTCTCAACCCTGGCTGCATATTAGACTCGTCAAAGACCTTTG


TAAAAGGTCACACATTGACTCGTCAAAGCCCCTCTCCAGACTAATTCAATTCAGAATCTCACAGATGGGGCCACAGAATCAGTATTT


TTTGACACAACCTCAAGTGAGAATATTGTGTAGACAAGATTGGAAACCACTGATTTAGATATAGAAACAAAGGCTAATCAACTGTGA


GAATTATGGTCACAGAATAGAAAGTAACTATTATGAACACTGAAAATGTAAAAAAAATGTAACAAAGAAAAATAGTTAGAGGAAGGA


GAGGAAGTAAAGGAACAATCATTTTCTCATGATTATTATTATTTCAGAGTAAATTGTGAGTTATTTCACAATTCAAAAAGAATGGAC


TGTTTTAAAAAATTAGTAATAGATTTCAAAATGTCCATTTTGTAAATCGTTTCTGAATACTTTGTCAACAGTTACTCATCATTAATG


GCTTATACTTCACTAAAATTCCATGGAAAACCAACTAGTAGCCTGTAGAGTCACATAGGAGAGAACAAGTGAATTCTTTGGGTGGCG


CAAGCATAGATGTTAGGACTGACAAAAAAAAAATAATAAAAATAAACCTGTGCATTGATATGATCACAAATGATCAGGGAAAGAGGA


AACAGAAACTCTCATACGCCATTATTACAAGTGTAAATTGGTTCAACCTTTTCGTCTTAATTGACACATTGTAATTGTATATATTTA


TGGAAGCACAGTTTGATATTTTGATATACATACATGGTATATAACGATCAAATTAGGATATTTAATGTACCCATCATCTCATGCATT


TATCATTTCTTTGGAATAAAAACATTCAAAAGCCTCTCTTCTAGCTTTTTTGTAATATATTATAACTGACCATTAACCATCATCACC


AATAGAACAGAATTTATTCCTCCTGTCAAATTATAACTTTATACCCATTGACCAACTTCTCCCTATCCTCCTCTTCCCTCTCCCCTC


CCCAGTCTCTGATAACCACAGTTCTATTCTCTGCTTCTATAGTATCAACTTTGTATTTTTTTAGATTCAAAATATGAGTGAAATCAT


GCAGTATCAGTCTCTCTGTGCCTGGATAATTTCATTAAATATGATATCCTCCAGGTCTTTTTATATTGCTGCAAATCACAGGATTTC


ATTATTTTTTATGGCTGAATACTATTCCATTGTGCATATATTCCACATTTTATTTATCTATTCATCTGCTGGGGGACACTTAGATTG


CTTCTATATCTTGGCTATTGTGAACAGGGCTGCAATAAACTTGAGAGTGCAGATATCTCTTTAACATAGCGACTTTATTTCCTTTGA


ATATCCACCCAGCAGTGAAATTGATGGATAATATGGTAGCTCTATTTTTATTTTATTGAGAAACTTCCATGCTGTTTCTTGTGGTGG


CTGTACTAATTTACAATGCCACCAGCAATGTAAGGGTTCCTTCCTCTCCACAACTTAACCAGCACTTGTTTTCTTCTGACTTTTTGA


TAACAGTCATTCTAACTGGAGTGAGGTTATACTTCATTGGCGTTTTAATTGTATTTCCCCAATAATTAGTGATATTGACCATTTTTT


TCATGTACCTGTTGTCCATTTTTATGTCTTCTTTAGAGAAATGTCTGTTAAAGTCTTTTGCCCATTTTTTAATCAGCTTGTTTGGTT


TTTTCCTGTTAAGCTCTTTATATATTCTGGATGTTAACACCTTGTCAGACATAAACTTTGCAAATATTTTCTCCCATTCTATAAGTT


GTCTTTTTACTCTGTTAATTGTTTCCTTTGCTGTGCAAATTCTTTTCAGCTTGATGTAATCCCATTTGTCTAATATTTGCTTTTGTT


GCCTGTACTTTTGTATTTTAAAAGGTCCAGTCTTTTAGAAGAACAATTTGACATTATATGTTATTACTTAAAATGTTTGTATACTTC


ATCCCAGAAATTCCATGTCTAAGAATTTATCCTAAGAAATGCATGTGTAAATATACAAAAATATATCTACAGAATTACTTAATGCAG


CATCACTTGACATTTAAGAAACAACAACATCCCAAACATCCATTAATGGGAAAATGCTTAAATGTATTATAGCATATCTATACAATG


GAATACTTTGTCATTGTTAAGAATAATCAGGTAAGTGGGGCATGGTGGCTCTCGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCG


GGCAGATCACCTGAGGTTGGGAGTTCAAGACCAGCCTGATGGAGAAACCCTGTCTCTACTGAAAATACAAAATTAGCCGGGTATGGT


CGTGCATGCCTGTAATCCCAGCTATTCAGGAGGCTGAGGCAGGAGAATCGCTTCAACCCGGATGGCGGAGGTTGTGCTGAGCCAAGA


TCGCGCCATTGCACTCCAGCCTGGGCAACAAGAGTGAAACTCTGACTCAAAATAAAATAAAATAAAATCAGGTAATATATTTCCAAA


ATTATCAAGTTGTAAATGTAAAAGTTATACTTTATTGTGTGTAAATTATGCTTTAATAAAGATGAGTTTTAAAAGTTAGTGATGTAA


ATTTTTAAGTAATACCACAGAAAGATGCCCATAATATATAGCTAAGGGGAAAAAGCAGGTTGTAGACCAGTATGTTATTGTGATCCC


ATGCACGTGTGTGATTTTAATGTATTTATTTATGTGTCTATGAGTGTACTTATACATAGAAAAGATCTAGAAAGTGTCACCAAATAC


TCAACAGAAGTAATTTCTGAAAAAATAAAGAAAATGGTAAAACTTTTTATTTTTACTTAGATAATTCTGTAAAGTTTGATTTTATTA


AATGAATAGCTGGGTTTTTCATTTTTAAAAAAATTTCAGTAGTTTTGGGGACCAGGTGGTGTTTGGTTACATGAGTAACTTCTTTAG


CAGTAATTTCCGAGATTTTGGTGCACTCGTTGCCAGAGCAGTGTACACTGAACCCAGTGTGTAGTACTTTATCCATCACCCCACTCT


CACTCTTCCACTGAATCCCCAGAATCTATTATATTATGCTTAGGCCTTTGCGTCCTCATAGCTTAGCTCCCACTGATAAGTGAGAAC


ATACAATGTTTGGTTTTCCATTCCTGAGTTACTTAGAATAATGGTCTCCAACTCCATCTAGGTTGCTGTGAATGCCATTATTTTGTT


CCTTTTTATGGCTGAGTAGTATTCCATAGTGTACACACACACACACACACGTGCGTATGTATCACATTTTCTTTATCCACCCCTTAA


TTGATGGGCATTTGGGCTGGTTCCATAGTTTTGCAATCATGAGTTGTGCTGCTATAAACACGTTTGTGCAAGTGTCTTTTTCATATA


ATGACTTCTTTTCCTCTGGGTAGATACCCAGTAGTGGGATTGCTGGATGAAATGGTAGTTCTACTTTTAGTTCTTTAAGGAATCTCC


ATACTGTTTTCATAGTGGTTGTAATAGTTTACATTCCCACCAGCAGTGTAAAACTGTTCCCTTTACACCACATTCATGCCAACATCT


ATTATTTTTTGTTTTTTTAATTATGACCATTCTTGCAGGAGTAAGGTGGTATCGCATTGTGGTTTTGATTTGAATTTCCTTGATAGT


GATGAGCACGTTTACATGTTTGCTGGCAATTTGTGTATCTTCTTTTGAAAATATTCTATTCATGTCCTTTGCCCACTTTTTGATGTG


ATTGTTTTTTCCTGATGATTTGTTTGAGTACTTTGTTGATTCTGGATACTGGTCCCATGTCAGATGCATAGTCTGTGAATATTTTCT


CCCACTCTGTGGGTTGTCTGTTTACTCTGCTGATTATTTCTTTTGCTGTGCAGAAGCTTTTAAATTTAATTCAGACCCATCTATTTA


TTATTGTTTTTGTTGCATTTGCTTTGGGTTCTTGGTCATGAACTCTGCCTAAGCCAACCAATGTCTAGAAGAGTTTTTTAAAGTATA


TTCCAGGGTTTATATGGTTTTAGGTCTCAGATTTATGTCTTTGATCCATCTTGAGTTGATTTTTGTGTAAGGTGAGAGATGAGGATC


CAGTTTCATTCTTCTACATGTGGCTTGTCAATGATGCCAGCACCATTTGTTGCATAGGGTGTTCTTTCCTCACTTTACATTTTTGTT


TCCTTTATCAAAGATCAGTTGGCTGTAAGTATTTGGCTTTATTTCTGTGTTCTCTCCTTCCATTGGTCTACCTGTCTGTTTTTATAC


CAGTACCATGCTGTTCTGGTAACTATAGCCTTGTAGTATCGTTCAAAGTCAGGTAATGTGATGCCTCCAGATTTGTTCTTTTTGCTT


AGTCTTGCTTTGGCTATGTAGGCTCTTTTTTTTGTTCCATATCAATATTAGGATTGTTTTTTCTAGTTCTGTGAAGAATTATGGTGG


TATTTTGATGGGAATTGCATTGAAGTTATAGATTGCTTTTGGTAGATGGCCATTTTCACAATATTGATTCTACCCATCCATGAGAAT


GGGATGTGTTTCCATTTGATTGTGTCATCTGCGATTTCTTACACCAGTGTTTTGTAGTTTTTCTTATAGATATCTTTCACTTACTTG


TGAAGGTGTATTTCTAAGTATTTTATTTTTGTAGGTGTCATAAACAAGTTTGAATTTTTTATTTGATTCTCAGCTTGGTCACTATTG


GTGTATAGCAGTGTTACTGATTTGTGTACATTGATTTTGTATCCTGAAACTTTACTGAACTCATTTATCAGATCTAGGAGCTTTTTG


GATGAGTCTTTACGGTTTCCTAGGTATACAATCATGTCATCAGTGAACAGCAACAATTTGACTTCTTCCTCTTTACCAATTTGGATG


TCCTTTATTTCTTTCTCTTGTCTGATTGTTCTGGCTAGGACAAAGAGCTGTTTCTAATTTTAAAAATACATGTGTCCCTAACTCATT


TTCTCTCTCAGTTCCAGTGTCTCGCCCCATCCTCACCCTCAGGGTTCCCAGGGCCCAGGCTGTGGTGGGCGACCTGCTGGAGCTTCA


CTGTGAGGCCCCGAGAGGCTCTCCCCCAATCCTGTACTGGTTTTATCATGAGGATGTCACCCTGGGGAGCAGCTCAGCCCCCTCTCG


AGGAGAAGCTTCTTTCAACCTCTCTCTGACTGCAGAACATTCTGGAAACTACTCATGTGAGGCCAACAATGGCCTAGTGGCCCAGCA


CAGTGACACAATATCACTCAGTGTTATAGGTAAGTTGACCTAACCAGCAGCACAAAAATAAAAAGACCATCTCCCCTAACTTTACCA


GTAGCCAAGATCAGAGGTACAGTTTCTAGAGTCATTTGCTGTGTGACATCCTGTCAGGCTTGGTGCCTACACAGCCTCCATCTCTGA


GTTTTGTATCCTACACGTTCAGGAACTTGCACCTTCCCTTCCCTTGCTGTACTTTTCCTGCTAGCAGCAGTCCAGCCATCACGACCA


AAATTCCCCTAACATAGGAGTAAAGGCTTTCAAAATACAAACTATATTCTGGCCAACAGTGATAGTAAGAAAGAAAGTTATAAAGTT


CTGTGTGCTTCACCTTGGAAGAGATTTAGTTGTGGTTTTCTCTGTCTGCCAATCAATAAAAAGGCCAACACAATTCTCTTATTGGCT


CACACATTTCTCTCTAGCCTCTCCTGCCCCTGTCCCAGAGTGGGTTGGGTTCCCACCCAAGACCCTTGTTAGAAGACATAATTCTTC


TGCCTCCTTACCTGCTCCTGTTCCATTCAGCAACATCAAGATCTTCCATGCATCCTTGTCACAGGCAGACTCCTAGTTATGCCCACT


CTCAGTGAAGGCTTTGGCACTGTACTTTCAGTCTTTCTCCATACTCCATAATCTGCCATCATTTCATGACTCTCATGGTCACATGTA


TAATCCCCTTAACACCATGGCCTGTCCTCTCCACACCAGTCAGCCACTCCCACATACATACACTACTTCATCTCCAAAAGGACAATT


TTAAGCCCTTATTATCTGACAACCACCCCCTGGCCTTCTGCTTGCGTCAGCTCCTCCTGTCACTATTGTTCTCAGACCTCAACAGAA


CTCCCAGGTCATTAATACCTCCACTAATTCCCTACTCCACTAGACAATAACCCCCTCCACTCCCACCACCAAATTGAGTGTCTAGCT


CTGTATCCACCCAATAACTCATCTGTCCTTTTCCTAAAATATAGAGGAGAGGACTTCCCTCCCCATAGGTCAACATCTCCATCTGGT


CTCCAGATTTCATCATTTTGTGCATTCTCAGAAGCTATGTAACTGATTATCCCTTTCTCTTCTGTGGCCCCCAACATCTCTGTCTCT


GTAGGATCCTTTGCACTCGCACGTAACATGGTATATCTCTCCCATATCCAAGGAAAACCCTCTCTTGGTCCCACTTATACCTCCATA


CACTACCCCTTCATGGCTAAACTTCCAAAAACAGTCAGTTACCCAGACTGTCTCCATGTCCTCACTATCCACTAGGCTCTAATCTAC


TAGGTTTTTCCAACCTCTCCACCAAAATGTTTCTCACAAAGGTCACCGATGACCTTCAAGGCTTTAAATCCAATGGCCATTTTTCAA


TCCTCATCTTCCTTGACATCTCAGATATATTACATGTTGTTTACCATTTCTTCCTTCTTGAAACCCTCCCTTCAGTGAATCTATCTT


CTTCTGGCTCTCTTCTCTCCCTGGCCACTTCTTCTCAGTCTTCTTTACTGGCTCCTCCTTTTATAGAAAACCTTTAAGCACTGGCAT


GTTCCAGAACTTTGACTTATGCCCTCTTCTCTTATCTAAATCCTTTGTCTGGATGATCCTGGGTATGTCATGTATAAATGGCCTTGT


CATCTATAAATAATGATTCCTAAACTTCTATCTCTAAAAGGGACCTCCCACTTGAGCATCTGCACATGACATACCTTCACTCAAATA


TCTCAAAAGCACATCAATCTGAGCATTTCTAAAACTGAACTGCTGACATTCCCTTCCTCTTTCAAGGGTTCCTACCTCTGTGAAACA


CATCTCTTCTCAACAGATACACAAAGCAGGAACAGAGGAGTCTTCCTCAACATTTCTCTTCCTCACCCCTCACAGCCAGTTAATCAT


TAAGTCCTGTTGATTTGACTTCCTAAATATTTCTTGGGTCTCTATCTCTACCACCTCTATCTAGACAAGTCCACCATCATTTTGACT


ACTGCAGTGCCACTCATCTATCCCTCAATTCCACTTCCATTCCACCACAGTCCATTTCATGCACAGAGGTCAAAATGGTCTTTTAAA


AGGGACAAATTTGATCATCTCACAGCCCTGCATAGATAGACTTATAGACTTCCCATTGCTCTGTGAACAAGGATCAAAATCCTTTCA


TGGCTTATGAAGTCCAGCCTAGATCTCCAGTCTCCTATTTCTTGGTAGTTTGCAGAATCTTCTCAGTGTGATGCTACTTTATTTCAA


TAATTCAAATGTGCCAGTCTTATTCCCAACTCAGGGCGTTTGCACATACTGTTTGCCTGCCTGGTGCACTCTCCACCTCCATCATCA


ACTGGTTAATTTCAATGTTAATTTCAAAGATCATTTTGTGAGGAAGCTTTCCTTGACTAACACATACATTTCATAGTACCCTGTCCT


TTATCAATTATCAAAGTTTTAATTGTAATTTACTGTATTTTTATTTAATTGCTGCCTCTCATCCTTCTAGATTGTAGGCTCTATGAG


AGCAGTAACTATGTCTTTCTCATCACTGATTCCCTAGCATGTCATGCCATTCTTGGGACTTATTAAATGCTCAATTAATTTTTATTT


TTGCTCAATTTTTAAAAAAATTTTTGTTCAATTAATTTTTGATGGATAAATGAATGTAAAAATGAGCAAATAACTTGACAATACTCA


TTCTCTTGTGGGCCCTATTTCTGATGCAGCCCAGATGCAATTACATCCCTGGTGATGTAAGCAGCAAGTCTCTCCTGTTCTTCATTT


TCTGTTGAACTGATTTCTCCTCTCTCCAACTGTCTTTTTACCTCTAAGACACCTGAGTTTCAGTTTAATCTTTGTTTTCACATTCTT


CAAACACATTTGAGTTTGTATATTCCACTATTCCAAGCTGTTTATAGCACTACACAAATGTTGTTCTTTCTGGAGATCTGAAAATAT


TGCTGAGTTTTGAGTAATGTCACAAGGGCATTAAAAACTGAGAAAAACATTCTTCCATTTGAAATGTCTTTAGCATGAAGGAATATA


TTTTAGCAGAAGCAGCTGATACATAACGTTTTTCCTCCCTCAGTTCCAGTATCTCGTCCCATCCTCACCTTCAGGGCTCCCAGGGCC


CAGGCTGTGGTGGGGGACCTGCTGGAGCTTCACTGTGAGGCCCTGAGAGGCTCCTCCCCAATCCTGTACTGGTTTTATCATGAAGAT


GTCACCCTGGGTAAGATCTCAGCCCCCTCTGGAGGAGGGGCCTCCTTCAACCTCTCTCTGACTACAGAACATTCTGGAATCTACTCC


TGTGAGGCAGACAATGGTCTGGAGGCCCAGCGCAGTGAGATGGTGACACTGAAAGTTGCAGGTGAGTGGGCCCTGCCCACCAGCAGC


ACATCTGAGAACTGACTGTGCCTGTTCTCCCTGCAGCTGAAAATGGAGCCACAGAGCTCCTCAGGGCTGTTTGCTTGTGTGGCATCC


CAGCACACTTCCTGCCTGCAGAACCTCCCTGTGAAAGTCTCGGATCCTTTGTGGTATGGTTCCAGGAATCTGATGTTTCCCAGCAGT


CTTCTTGAAGATGATCAAAGCACCTCACTAAAAATGCAAATAAGACTTTTTTAGAACATAAACTATATTCTGAACTGAAATTATTAC


ATGAAAATGAAACCAAAGAATTCTGAGCATATGTTTCTCTGCCGTAGAAAGGATTAAGCTGTTTCTTGTCCGGATTCTTCTCTCATT


GACTTCTAAGAAGCCTCTACTCTTGAGTCTCTTTCATTACTGGGGATGTAAATGTTCCTTACATTTCCACATTAAAAATCCTATGTT


AACATAAGCTATGTGTACAGCCCTTCAGGAGACACACTCAGCGATCTTTAAAGCAAGGGACACAGGTCACCAGGGCAGAGAGTGGGG


AGCAGGATGACATGGAATGGAAATGGACATCCATCACCCAAATTCCTCTATTCTCGAAGCTGTTCTTTGATCTCTTTCAATTAAGTG


TAATAACCCAAGGAAAGCTGCTTCTAGTGAGCTCTGAATCTTTTTGGTGATGACCTCCTACAAGCCAAACTTTGAAACCTCTGTTTA


GAGAGAACTGGTGTTTAGCAAAAGTATGCTAAGGGGTGTTGAGATGAATCTTCTAGACTTGGATCTGAAGATAACTAGCTGTATGAC


ATTGGCCAAGCACCTCTTCCCATACTGACCTCAATTTCCACACCCACAAAGTGGGAAAATCAGACTAGATGAAAATCATGATCATCC


TTTGTCCTAGAATTCTATGATTTTGGTAGACAGGGAATATGGATTATGCAGACGTACAGGTTCCTAGAAGGAGATATGCAAAAGTAA


AAGCAGGTTGTACCTGCCCCTGGAATATATCCTGGAGAAACACGAGACCATACAATGGTATGCAATCACCATTCCAGTCATGTAAAG


CAAAATATACACTGATGCTCTTATTCCCTTTGGCAAGGTGCCTGGGTATCATAAGGAATAGACAGAGTCACATAAGCAGGTTGATCT


GGGCATGCTAACCCATGATCCAGCATCTCACAAAGTAGCCAGTGCAACCATCTCATTGTTATCCAGGAGGTGATGACTTCAGATTTG


GGTTTTCCCATTCAGTCAGCTCGTTCTTCTTCCCCCACCAGCAGCACCAACCTCATCCAATTTTCCTGAGATTTGCAGGGGCTCTCC


CCACACAGTTTACACACCTATCCCTTAGAGCCAGCACACAGGCATGTACCACGGACCGAGGGCTGCTCCATCTTTCCTCACAATACA


GCAAGCCAACACATCATACCTCCTACATTCTATACTTATGATTTCATGATTTTCTGCTCATCCTCACTCCCTCATTTCTATAATTCT


CTGTCGCAAATGCATGTTATTTCTGCTGCTGTTATCACAGCTAAAGGGTTTCTTGCCCAGCCTGAATGAATTGTGTCTGAATCCTGA


AACTAGGACCCAGGTCATAGAGACCAGGAGCTGCCAGAAAAGGAAATATTATTTCTTATTATCATCATAACCAGTGTCATCATCATC


AACACTCACTGAGCCTTCACCAGGTTCCAGGCTCTGTGCTAAATGTTTAATAGGCAACATCTCATTTAATTATTAAGATAAACCTGT


GAGGATAAATTTTAAGCCATCGTATCCCCTATTTGCGGAAAAGAGACTGAGGTTTAGAGAAGTGAAGTAACTAGCTTGCAGACACAC


AGCTAGCCAGGGTAAAGCCAGGTTGAAGCACAGTCCTCTCTAACTCTTCACAETAGTCTGATACATGATGACATTTTCTCATCCGTT


GTGGCCACTTTTAACACAACATTTTAGTTTTTAGTAATTTGTTATTCTGAAAGAACACATGAATGTTTGTGATGAAAAAAATCAAAT


AATACAAAAGGGCCAATATTGAAAAGTAAAGGTCTCTTTCTACCTGCTCATATCACTTCTTACGCACATATTCTCCAGACATAACCA


CTGTTAATTGTTTCATGTGTATGCTTCTAGAAATAATCTACAAACCTAAAGGTAGATAATTTTTAGAAAGCTAGAATAATATTACAC


ATATAGTTATGCCAGTTGCATTTTTTAACTTAAAATACATCCTGACTTTTGTTTAAGAAATGCATCTTGGATATCATTCATGTTTCA


TTACCCAATCCAGTAGGTTGTCTCTAATTTTTAGCTCTTGTAAAAATGCTACAATAGAAATTCTTGTAGAAATATATTGGCATATTT


TATGTCAGTATCCCTAAAGGAGATGGCCCTAGAAGTAGGACTTGAACTCCTGGGCTCAAGTAATCCTCCTGCCTCATACTCCCAAAT


CGCTGGGATTATAGGTGTGAGCCACTACACCTGGCCCACTAGAAGCAGATTTGTTGGGTCAAAGTTTATGTGCACTTTAAATTTTGT


AGATATTGCCAAGTTGCCATTCAAGGAAGTGTGTTAAATTTGTATTACCACCAAGGGCATATGTAGGTGCCTGTTTATCTACAAGCT


AATCACTATGATCAGTCTATTTAAGCTTTGCCAACCTGAAAAATAGAAAAAAGAATAGTATTGTATGGTTGTCTTTGTGTTTAGTTA


ATTAGTAATGAAGATGAGAATCTTTGTATATATTTATTGTCTATTTGAAGTTTTCAGTGATTTATACACTTTTTACAGTTTTCTATT


GGATATTTTTGTACACTGAAAACTATTAGCAGGTCAAAGTAATTAGCTTTATCATCTATGTTTTAATCTACTTTCCAAGATTGAGTT


ATGACTTTTTACATTTGTTTATGATACCTTTTGTTTCTTACAAATATGTTAGAAGCAGAAACTGCTGTTGACTTTTTGTTCTCTTTC


AGTTCCGGTGTCTCGCCCGGTCCTCACCCTCAGGGCTCCCGGGACCCATGCTGCGGTGGGGGACCTGCTGGAGCTTCACTGTGAGGC


CCTGAGAGGCTCTCCCCTGATCCTGTACCGGTTTTTTCATGAGGATGTCACCCTAGGAAATAGGTCGTCCCCCTCTGGAGGAGCGTC


CTTAAACCTCTCTCTGACTGCAGAGCACTCTGGAAACTACTCCTGTGAGGCCGACAATGGCCTCGGGGCCCAGCGCAGTGAGACAGT


GACACTTTATATCACAGGTAAGTTTCCCGTGCCCGGGCCACAGATGCGGACAAAATGTTTCCTCCGCGGACCCTCTGATAACCCTCA


CAGTGCTTGATCAGAAAGGCACTCCTCAGGGCGAAGTAACACAGCTGGCAGCTCTCTAAACTGCTATATTTCCTGAAGTGCTTCTGA


AGTGATGGCGTTGGGGCTGAGAGCGCGGGTTGGCGGGCTGGGCGCAAGAGCGCCACTGACTTTAGAGGTCCTCACCTGGCTGCCTCC


TCTCTCACTGGCCACCGGCCACCCTGACCCTGGACACTTGTCTCAGGCGCAGAGACGGCTTCCTCACAAAGACAGGAGCCATCTTCT


GTGCCACACCAGCCCCTGCTTAGCTGCCGGGGACCTGCTCACCTAGGTTCACCGTCAGGCCCAGGCAGCAGCTTCCGGGAGCGGGCA


GTTCCAGACCACAGCCTCTCCTCTGGCTCACACACAGGGTCTCCCCCTCAGGGCTGACCGCGAACAGAAGTGGCCCTTTTGCCACAG


GAGTCGCCGGGGGCCTGCTCAGCATAGCAGGCCTTGCTGCGGGGGCACTGCTGCTCTACTGCTGGCTCTCGAGAAAAGCAGGTGGGT


GACTCTGGCCACACCTTGGCTTGAGTTCATGCCCTTCCCAGCAACGCTCCCTTGGGCTTCATGCTGCCTTTGTGACCATCCCAGGCT


CGCAAGAGCTCATCCGCTCTGTCCCTCAATCCTCTTCCTTTCCCGCTGGGTCCTCCCGAATTGCTTTTACCAAATGCACAGTTTCCA


AAACAGACCTATAAGGTGGGAGACGTCTTGATGAGATGTAGTTTATCCAACATCATAAACTACAGAGTGTCTTCCTCTCGACCCTTA


TAAGACCCCCCCAACGAATGGGAAGAGGAGGAGAAAAACTCAGAGAAATAGAAATGAAAATAGAAACCAGATAGGATTCAGTAATTT


TCCGATTTTTTAAATGTACACTATTTTTATAGTTGATCAAGTCTGTTTTCCTGCCTTGGAGATTATCTTTAAAATCTCCAGGTTAAA


GGATTACGGATTGTGGACTCCCGTTTCACATCATAGCAAACCCCTCTGGCAGGGTCAGTAGTTTTTGCCCAATCTGCTACCTCCCTG


GGGCATAACAAAGAAGGATTCAACCTTCAGTGACAGCAACTCCTGGCAGTTTCTAAGTGAGCCTTGCCTGAGCTGTGCCCCACTGAG


GGTCTCATCTTCCTGAATCCAATGCTCCTCTGCTTTCCTTTACAGGGAGAAAGCCTGCCTCTGACCCCGCCAGGTAAGAGCTGAGCT


GCATTCCTGTGTGATTAGTGAAATGTCCACAGGGTGGAAAAATGGAATTGAATCTGATGATTACCAAGAGCACAGTTTCTGCCAGGT


GCTGCTGAGCTGGGGTGTGGCCACTACCTGTTGTACGTCCCTGGGGATATCTTAAGGCAATTCCCAGGACCTTTGCACCCACCCCCT


TAGCTGTATAGGCTGTTATCTCATCAAGTATTAATTGTCTTTTCATTTATTAACCCACATCCTTGGACCATTGTTGGCTTGGTTGTC


TGAATGACCACTATGACCACCAAGTCTTTCCATATCTTGAGATGACCTTAGCTCAGTCAACCTAGAAATCTCTGGAGATGCTGATCT


CATCAACACCTCTTGTGATAACAACTGAGAAGATGGAGCCGCACAACTTGGCCACCCAGAGAGGTCACTCTGCCAGCAGGAGGTAGT


CCCTGTGAAGAAGGGGCCACCATCTTGTATCCCTAAGGCTGACTTTAGGAGCCACACAAAGGCTCACAGCTATCCCTGGGCAAGCCC


ACGATAGCAGCATCCAAACATGTAGAGCACCTCGGAGCCTTCTGGTCACTGATCTCTCTGAGCATGCAGGGTTCGGAGCCAGCTTTG


AGCCTTGGCTCATCCCCTTTCTGGTTACATGATCTTCATAAGTCACTTATTGGAGCCTCCGTTTGTTTCAGCTAAAACGAGGATGAA


ATAGAACTAACAACGTATTGCTGTAAGCATCAGCACCATGCCTGTTACACACTAGATGACCAGAAAGCCTGGAAACATATATAATAT


GATTATGATTCATAATAGAATGCCCATGGTCAGTTTGTTATGTACTTGTTCATGTTTCCAGGCCTGGCAGCCACCCTGCAGTAAGAA


GTCACTCACTAGGAGTGATCATTATAGCTACTTTGTCTGGATTCCTAAGAAACATTCACATTTCTCTGTCTCACAGGAGCCCTTCAG


ACTCGGACTCCCAAGAGCCCACCTATCACAATGTACCAGCCTGGGAAGAGCTGCAACCAGTGTACACTAATGGTGAGGCCCGAGGAT


CCTGCATTTGGCAGAAGCTGGAGGGCTGGTGTGGGAAAGCGGTGGGGCAGGAGATGGGGAGGGACTATGCCGAGGCCTAGAGGGCTC


TAGTCCTTCCAGAAAAGAGACTCTGGCTGGGGGAGGAGGAAGTATCTCTAACAAGAGGCAAGAACCTCAGCATCCTCTGAAACTTCA


ACTTTTTTCTAAGCAAATCCTAGAGGAGAAAATGTGGTTTACTCAGAAGTACGGATCATCCAAGAGAAAAAGAAACATGCAGGTAAG


ACCCAAGGATGTCTCTGTTCTGGCCCACCCTCAACTTAGACAGTATAGCTCAGTTTCTACCCACTCAGCAGATCTGAGCCAGACAGG


CATAGAGCCGCCCCTCCCACTGGGTCATGGGGCTTCTTTATGTGTGCCTATGCTGCTTCAGGTGAATCCAAGCCTCCCCTGCACTCT


CCTTTCCCTATTCTCTGCAGAGGGCCCCAGTATAACCTGAATAACAAAACTATCTTTTTGGGCATTCGCTTAACCTCTCAGACCTTC


CATATCCCTATCCATAAACTGTGACTACTTCCCTACTGTCTTAGTCAGTTCTGGCTCCTGTAACAGAGTACCATAAACTAGGTGACT


TAAAGAACTAATATCTATTTCTCACAATTCTGGAGGCTGGAAATCCAAGATCAAGGTGCCAGCATGGTCAGGTTCTTAGTGAGGGCC


CTATTCCCATTTTCCAGACAGATGACTCCTTGCTGTATCCCCCACACAGCAGAGAGAGAGGGAGAGATCATCTTTCATGTCTCATCA


TGATAATCATCATGACATAATTGTCACCCAAAGGCTCCACCTCCAAATGCCATCACATTGGGGATTAGGTTTTAACCCATACATTTG


GAGAGCAACACAAATATTTAGTTGATAGCACCTACCTACCTGTACTAGTTTCTGATTGCTGCTGTGACAAATGACCATAAATTTGGG


GGGATGAAGCAGTACAAATTTATCATCTTACAGCTCTGTGGGTCAGAAGTCTGACGCCGGTCTCACTGGGCTAAAATCATGGTGTTG


GCAGGGCTGTGTTCCTCCCTGGAGGCCCATCCACTTTCCTGCACCCATGTCCCCTTCCTTTCCCAAAGCCAGCAAAGTCACATTTCT


CTAATCATTCTTCCATAGACAGGCCTCCTTCTGACCTCACCTGAGAAAAGTCCTTGGGTTTTAGAGAATCATATGAGTATATTGGGC


CCATCTGGATAACCCAGAATAATCTCCCTATCTCAGGGTCTGTAATCCTAATCACATCTGAAAGGTCCTCTTTTCCACTTAGGGTAA


TATAGTCACAGGTTGCAGCAATTAGGGCGTGACATCTTTGGGGGCACATTATTACAGCTACCATGCTGTTTCATGGGGTAACTGTGG


GGACTAAATGAGAAAATAGGTGTGGAAATGCTGTCGAAACTGCAGAGGGTTGACCAGCTGTGACGATGACTACATGCTGGAGGTCTG


GCTATGTCATCAACCCTCACTCACAGTCGGTGGTTTGAAATGAGGGAATCCCAGCCCGGCTGCCTCCTTACTCGGAGCAGGAAAGAG


GAACAAAGTCCTTCACGGCAGGCTTTTCTTTCTACCTCTGCTTCATAAAAAGTGCTGCGTGATTTTAGCCAGTGTGCTTCCCTCTCT


GGTTTTCTAATTTTTCTTATATAAAGTCAAGTGAATTGTGTTTGTGCCTCATTCTTGGTTCTATAGCACCCCTCTGAGACATGTGAA


CTCATTCACTCTTACAAGCCCCTTTGAGGTATGCGCTGTTACTACTCCCATTTTACAGATGAGGAAACCAAGGCATAGACACCTTAA


ATGACTTGCCTGAAATCTTATAGTCAATCACCAAACAGTCTTCTCCAGAGTCCAAACTCTAGACCAAACTCTGCTTCTTCATGCAAT


TCCAGGGAGTCCTGATGCTCATTCCAAGCCAAAAGGGCAGAGCCTTGTCTGGAGAATGTCATATTTCTCTCCAGTTTGATGATAATA


TAACAATAATAATTTATAATATCTATCATGTGCTGAATAGTTCCTATTATGTGCTGGGTATAGTTCTATAAGTGCGATAAATAAATA


CACTATATTTGTATGGATAGCTCTTAGAACTATACCTGTAGCACTTATATAGAACTATGGCATGCATACATATGATAATAGAGAGAG


AGAAAATGTATTGAATATAGCAATCAGGACTGTACCTGACACATAGAAACTGCTCAATACATGACAGATGATAGAAATAATATATGC


ACAGACACACAGATACATGTGCTCACACATATGTGTAAACTCATATAGCTTCACCACAACCTTACAGGCAGAGGATATTTTTATTCC


CATCATATAGATGAGGCAACTGAGGCAAGAGATGTTGAGTGACTTCCCCCAACCACGGAGGTGACAAGACAGGCGGCAGGCTCAGTT


TCAGGTGGTCTAGACCCTGATGGAGTGTGCTCTCTAAAACTTGCACCCACCACACCTTCCCAGAACAATAATACCAATTATGCTCAA


ATAACTAACAAGATAAAAGACAAATGACTTTCTCTTGAGGGCCTCTAGGCAGCTCAGAGTGGGCCACAAAGTGTGAAGGGGAGTTGA


AGAGAGGGTCTGTCAGTGCTGAGAGGCTGAGGGAGTTGGGAATGGAGAGGGACTGGGTGAGCACCAACTAAGAGGAATGGCTACTCA


CCGCACAGAGGGAGAGCGGGCCTCCAGGAGGCTCAGGGCTGGCCCCACAGCGCAGGCGCAAGGGAAGAGCCCCATGCCAGTCTTCCA


CAACTGAACACTTTCCTCTTTCCACAGTGGCCTCTGACCCCAGGCATCTCAGGAACAAGGTGAGTCTCCCCTTCTGCATGCCCTCCC


CCACCCCCAGGCCCACCCTGGTCCTCACGCATGTGCTCTTGCCTCCTAGGGTTCCCCTATCATCTACTCTGAAGTTAAGGTGGCGTC


AACCCCGGTTTCCGGATCCCTGTTCTTGGCTTCCTCAGCTCCTCACAGATGAGTCCACACGTCTCTCCAACTGCTGTTTCAGCCTCT


GCACCCCAAAGTTCCCCTTGGGGGAGAAGCAGCATTGAAGTGGGAAGATTTAGGCTGCCCCAGACCATATCTACTGGCCTTTGTTTC


ACATGTCCTCATTCTCAGTCTGACCAGAATGCAGGGCCCTGCTGGACTGTCACCTGTTTCCCAGTTAAAGCCCTGACTGGCAGGTTT


TTTAATCCAGTGGCAAGGTGCTCCCACTCCAGGGCCCAGCACATCTCCTGGATTCCTTAGTGGGCTTCAGCTGTGGTTGCTGTTCTG


AGTACTGCTCTCATCACACCCCCACAGAGGGGGTCTTACCACACAAAGGGAGAGTGGGCCTTCAGGAGATGCCGGGCTGGCCTAACA


GCTCAGGTGCTCCTAAACTCCGACACAGAGTTCCTGCTTTGGGTGGATGCATTTCTCAATTGTCATCAGCCTGGTGGGGCTACTGCA


GTGTGCTGCCAAATGGGACAGCACACAGCCTGTGCACATGGGACATGTGATGGGTCTCCCCACGGGGGCTGCATTTCACACTCCTCC


ACCTGTCTCAAACTCTAAGGTCGGCACTTGACACCAAGGTAACTTCTCTCCTGCTCATGTGTCAGTGTCTACCTGCCCAAGTAAGTG


GCTTTCATACACCAAGTCCCAAGTTCTTCCCATCCTAACAGAAGTAACCCAGCAAGTCAAGGCCAGGAGGACCAGGGGTGCAGACAG


AACACATACTGGAACACAGGAGGTGCTCAATTACTATTTGACTGACTGACTGAATGAATGAATGAATGAGGAAGAAAACTGTGGGTA


ATCAAACTGGCATAAAATCCAGTGCACTCCCTAGGAAATCCGGGAGGTATTCTGGCTTCCCTAAGAAACAATGGAAGAGAAGGAGCT


TCGATGAGGAAACTGTTCAGCAAGAGGAAGGGCTTCTCACACTTTCATGTGCTTGTGCATCACCTGAGGATCCTGTGAAAATACAGA


TACTGATTCAGTGGGTCTGCGTAGAGCCTGAGACTGCCATTCTAACATGTTCCCAGGGGATGCTGATGCTGCTGGCCCTGGGACTGC


ACTGCATGCATGTGAAGCCCTATAGGTCTCAGCAGAGGCCCATGGAGAGGGAATGTGTGGCTCTGGCTGCCCAGGGCCCAACTCGGT


TCACACGGATCGTGCTGCTCCCTGGCCAGCCTTTGGCCACAGCACCACCAGCTGCTGTTGCTGAGAGAGCTTCTTCTCTGTGACATG


TTGGCTTTCATCAGCCACCCTGGGAAGCGGAAAGTAGCTGCCACTATCTTTGTTTCCCCACCTCAGGCCTCACACTTTCCCATGAAA


AGGGTGAATGTATATAACCTGAGCCCTCTCCATTCAGAGTTGTTCTCCCATCTCTGAGCAATGGGATGTTCTGTTCCGCTTTTATGA


TATCCATCACATCTTATCTTGATCTTTGCTCCCAGTGGATTGTACAGTGATGACTTTTAAGCCCCACGGCCCTGAAATAAAATCCTT


CCAAGGGCATTGGAAGCTCACTCCACCTGAACCATGGCTTTTCATGCTTCCAAGTGTCAGGGCCTTGCCCAGATAGACAGGGCTGGC


TCTGCTGCCCCAACCTTTCAAGGAGGAAACCAGACACCTGAGACAGGAGCCTGTATGCAGCCCAGTGCAGCCTTGCAGAGGACAAGG


CTGGAGGCATTTGTCATCACTACAGATATGCAACTAAAATAGACGTGGAGCAAGAGAAATGCATTCCCACCGAGGCCGCTTTTTTAG


GCCTAGTTGAAAGTCAAGAAGGACAGCAGCAAGCATAGGCTCAGGATTAAAGAAAAAAATCTGCTCACAGTCTGTTCTGGAGGTCAC


ATCACCAACAAAGCTCACGCCCTATGCAGTTCTGAGAAGGTGGAGGCACCAGGCTCAAAAGAGGAAATTTAGAATTTCTCATTGGGA


GAGTAAGGTACCCCCATCCCAGAATGATAACTGCACAGTGGCAGAACAAACTCCACCCTAATGTGGGTGGACCCCGTCCAGTCTGTT


GAAGGCCTGAATGTAACAAAAGGGCTTATTCTTCCTCAAGTAAGGGGGAACTCCTGCTTTGGGCTGGGACATAAGTTTTTCTGCTTT


CAGACGCAAACTGAAAAATGGCTCTTCTTGGGTCTTGAGCTTGCTGGCATATGGACTGAAAGAAACTATGCTATTGGATCTCCTGGA


TCTCCAGCTTGCTGACTGCAGATCTTGAGATATGTCAGCCTCTACAGTCACAAGAGCTAATTCATTCTAATAAACCAATCTTTCTGT


A





HUMAN mRNA SEQUENCE:hR27-007.1 (Seq ID No: 17)


AATTCACTAATGCATTCTGCTCTTTTTGAGAGCACAGCTTCTCAGATGTGCTCCTTGGAGCTGGTGTGCAGTGTCCTGACTGTAAGA


TCAAGTCCAAACCTGTTTTGGAATTGAGGAAACTTCTCTTTTGATCTCAGCCCTTGGTGGTCCAGGTCTTCATGCTGCTGTGGGTGA


TATTACTGGTCCTGGCTCCTGTCAGTGGACAGTTTGCAAGGACACCCAGGCCCATTATTTTCCTCCAGCCTCCATGGACCACAGTCT


TCCAAGGAGAGAGAGTGACCCTCACTTGCAAGGGATTTCGCTTCTACTCACCACAGAAAACAAAATGGTACCATCGGTACCTTGGGA


AAGAAATACTAAGAGAAACCCCAGACAATATCCTTGAGGTTCAGGAATCTGGAGAGTACAGATGCCAGGCCCAGGGCTCCCCTCTCA


GTAGCCCTGTGCACTTGGATTTTTCTTCAGCTTCGCTGATCCTGCAAGCTCCACTTTCTCTGTTTGAAGGAGACTCTGTGGTTCTGA


GGTGCCGGGCAAAGGCGGAAGTAACACTGAATAATACTATTTACAAGAATGATAATGTCCTGGCATTCCTTAATAAAAGAACTGACT


TCCATATTCCTCATGCATGTCTCAAGGACAATGGTGCATATCGCTGTACTGGATATAAGGAAAGTTGTTGCCCTGTTTCTTCCAATA


CAGTCAAAATCCAAGTCCAAGAGCCATTTACACGTCCAGTGCTGAGAGCCAGCTCCTTCCAGCCCATCAGCGGGAACCCAGTGACCC


TGACCTGTGAGACCCAGCTCTCTCTAGAGAGGTCAGATGTCCCGCTCCGGTTCCGCTTCTTCAGAGATGACCAGACCCTGGGATTAG


GCTGGAGTCTCTCCCCGAATTTCCAGATTACTGCCATGTGGAGTAAAGATTCAGGGTTCTACTGGTGTAAGGCAGCAACAATGCCTC


ACAGCGTCATATCTGACAGCCCGAGATCCTGGATACAGGTGCAGATCCCTGCATCTCATCCTGTCCTCACTCTCAGCCCTGAAAAGG


CTCTGAATTTTGAGGGAACCAAGGTGACACTTCACTGTGAAACCCAGGAAGATTCTCTGCGCACTTTGTACAGGTTTTATCATGAGG


GTGTCCCCCTGAGGCACAAGTCAGTCCGCTGTGAAAGGGGAGCATCCATCAGCTTCTCACTGACTACAGAGAATTCAGGGAACTACT


ACTGCACAGCTGACAATGGCCTTGGCGCCAAGCCCAGTAAGGCTGTGAGCCTCTCAGTCACTGTTCCCGTGTCTCATCCTGTCCTCA


ACCTCAGCTCTCCTGAGGACCTGATTTTTGAGGGAGCCAAGGTGACACTTCACTGTGAAGCCCAGAGAGGTTCACTCCCCATCCTGT


ACCAGTTTCATCATGAGGATGCTGCCCTGGAGCGTAGGTCGGCCAACTCTGCAGGAGGAGTGGCCATCAGCTTCTCTCTGACTGCAG


AGCATTCAGGGAACTACTACTGCACAGCTGACAATGGCTTTGGCCCCCAGCGCAGTAAGGCGGTGAGCCTCTCCGTCACTGTCCCTG


TGTCTCATCCTGTCCTCACCCTCAGCTCTGCTGAGGCCCTGACTTTTGAAGGAGCCACTGTGACACTTCACTGTGAAGTCCAGAGAG


GTTCCCCACAAATCCTATACCAGTTTTATCATGAGGACATGCCCCTGTGGAGCAGCTCAACACCCTCTGTGGGAAGAGTGTCCTTCA


GCTTCTCTCTGACTGAAGGACATTCAGGGAATTACTACTGCACAGCTGACAATGGCTTTGGTCCCCAGCGCAGTGAAGTGGTGAGCC


TTTTTGTCACTGTTCCAGTGTCTCGCCCCATCCTCACCCTCAGGGTTCCCAGGGCCCAGGCTGTGGTGGGGGACCTGCTGCAGCTTC


ACTGTGAGGCCCCGAGAGGCTCTCCCCCAATCCTGTACTGGTTTTATCATGAGGATGTCACCCTGGGGAGCAGCTCAGCCCCCTCTG


GAGGAGAAGCTTCTTTCAACCTCTCTCTGACTGCAGAACATTCTGGAAACTACTCATGTGAGGCCAACAATGGCCTAGTGGCCCAGC


ACAGTGACACAATATCACTCAGTGTTATAGTTCCAGTATCTCGTCCCATCCTCACCTTCAGGGCTCCCAGGGCCCAGGCTGTGGTGG


GGGACCTGCTGGAGCTTCACTGTGAGGCCCTGAGAGGCTCCTCCCCAATCCTGTACTGGTTTTATCATGAAGATGTCACCCTGGGTA


AGATCTCAGCCCCCTCTGGAGGAGGGGCCTCCTTCAACCTCTCTCTGACTACAGAACATTCTGGAATCTACTCCTGTGAGGCAGACA


ATGGTCTGGAGGCCCAGCGCAGTGAGATGGTGACACTGAAAGTTGCAGGTGAGTGGGCCCTGCCCACCAGCAGCACATCTGAGAACT


GACTGTGCCTGTTCTCCCTGCAGCTGAAAATGGAGCCACAGAGCTCCTCAGGGCTGTTTGCTTGTGTGGCATCCCAGCACACTTCCT


GCCTGCAGAACCTCCCTGTGAAAGTCTCGGATCCTTTGTGGTATGGTTCCAGGAATCTGATGTTTCCCAGCAGTCTTCTTCAAGATG


ATCAAAGCACCTCACTAAAAATGCAAATAAGACTTTTTTAGAACATAAACTATATTCTGAACTGAAATTATTACATGAAAATGAAAC


CAAAGAATTCTGAGCATATGTTTCTCTGCCGTAGAAAGGATTAAGCTGTTTCTTGTCCGGATTCTTCTCTCATTGACTTCTAAGAAG


CCTCTACTCTTGAGTCTCTTTCATTACTCGGGATGTAAATGTTCCTTACATTTCCACATTAAAAATCCTATGTTAACA





HUMAN PROTEIN SEQUENCE:hP27-007.1 (Seq ID No: 18)


MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEILRETPDNILEVQESGEYRCQA


QGSPLSSPVHLDFSSASLILQAPLSVFEGDSVVLRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCC


PVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCK


AATMPHSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTE


NSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIEEGAKVTLHCEAQRGSLPILYQFHHEDAALERRSANSAGGVAIS


FSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSV


GRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGS


SSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHE


DVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAGEWALPTSSTSEN*





HUMAN mRNA SEQUENCE:hR27-007.2 (Seq ID No: 19)


AATTCACTAATGCATTCTGCTCTTTTTGAGAGCACAGCTTCTCAGATGTGCTCCTTGGAGCTGGTGTGCAGTGTCCTGACTGTAAGA


TCAAGTCCAAACCTGTTTTGGAATTGAGGAAACTTCTCTTTTGATCTCAGCCCTTGGTGGTCCAGGTCTTCATGCTGCTGTGGGTGA


TATTACTGGTCCTGGCTCCTGTCAGTGGACAGTTTGCAAGGACACCCAGGCCCATTATTTTCCTCCAGCCTCCATGGACCACAGTCT


TCCAAGGAGAGAGAGTGACCCTCACTTGCAAGGGATTTCGCTTCTACTCACCACAGAAAACAAAATGGTACCATCGGTACCTTGGGA


AAGAAATACTAAGAGAAACCCCAGACAATATCCTTGAGGTTCAGGAATCTGGAGAGTACAGATGCCAGGCCCAGGGCTCCCCTCTCA


GTAGCCCTGTGCACTTGGATTTTTCTTCAGCTTCGCTGATCCTGCAAGCTCCACTTTCTGTGTTTGAAGGAGACTCTGTGGTTCTGA


GGTGCCGGGCAAAGGCGGAAGTAACACTGAATAATACTATTTACAAGAATGATAATGTCCTGGCATTCCTTAATAAAAGAACTGACT


TCCATATTCCTCATGCATGTCTCAAGCACAATGGTGCATATCGCTGTACTGGATATAAGGAAAGTTGTTGCCCTGTTTCTTCCAATA


CAGTCAAAATCCAAGTCCAAGAGCCATTTACACGTCCAGTGCTGAGAGCCAGCTCCTTCCAGCCCATCAGCGGGAACCCAGTGACCC


TGACCTGTGAGACCCAGCTCTCTCTAGAGAGGTCAGATGTCCCGCTCCGGTTCCGCTTCTTCAGAGATGACCAGACCCTGGGATTAG


GCTGGAGTCTCTCCCCGAATTTCCAGATTACTGCCATGTGGAGTAAAGATTCAGGGTTCTACTGGTGTAAGGCAGCAACAATGCCTC


ACAGCGTCATATCTGACAGCCCGAGATCCTGGATACAGGTGCAGATCCCTGCATCTCATCCTGTCCTCACTCTCAGCCCTGAAAAGG


CTCTGAATTTTGAGGGAACCAAGGTGACACTTCACTGTGAAACCCAGGAAGATTCTCTGCGCACTTTGTACAGGTTTTATCATGAGG


GTGTCCCCCTGAGGCACAAGTCAGTCCGCTGTGAAAGGGGAGCATCCATCAGCTTCTCACTGACTACAGAGAATTCAGGGAACTACT


ACTGCACAGCTGACAATGGCCTTGGCGCCAAGCCCAGTAAGGCTGTGAGCCTCTCAGTCACTGTTCCCGTGTCTCATCCTGTCCTCA


ACCTCAGCTCTCCTGAGGACCTGATTTTTGAGGGAGCCAAGGTGACACTTCACTGTGAAGCCCAGAGAGGTTCACTCCCCATCCTGT


ACCAGTTTCATCATGAGGATGCTGCCCTGGAGCGTAGGTCGGCCAACTCTGCAGGAGGAGTGGCCATCAGCTTCTCTCTGACTGCAG


AGCATTCAGGGAACTACTACTGCACAGCTGACAATGGCTTTGGCCCCCAGCGCAGTAAGGCGGTGAGCCTCTCCGTCACTGTCCCTG


TGTCTCATCCTGTCCTCACCCTCAGCTCTGCTGAGGCCCTGACTTTTGAAGGAGCCACTGTGACACTTCACTGTGAAGTCCAGAGAG


GTTCCCCACAAATCCTATACCAGTTTTATCATGAGGACATGCCCCTGTGGAGCAGCTCAACACCCTCTGTGGGAAGAGTGTCCTTCA


GCTTCTCTCTGACTGAAGGACATTCAGGGAATTACTACTGCACAGCTGACAATGGCTTTGGTCCCCAGCGCAGTGAAGTGGTGAGCC


TTTTTGTCACTGGTAAGTGCTGGGTTCTTGCCAGTCACCCACCCCTGGCTGAGTTCTCTCTCACCCATTCCTTTAAAAATCTGTTTG


CACTGTCCAGTTTCCTCCCC





HUMAN PROTEIN SEQUENCE:hP27-007.2 (Seq ID No: 20)


MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEILRETPDNILEVQESGEYRCQA


QGSPLSSPVHLDFSSASLILQAPLSVFEGDSVVLRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCC


PVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCK


AATMPHSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTE


NSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEDAALERRSANSAGGVAIS


FSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSV


GRVSFSFSLTEGHSGNYCTADNGFGPQRSEVVSLFVTGKCWVLASHPPLAEFSLTHSFKNLFALSSFLP





HUMAN mRNA SEQUENCE:hR27-007.3 (Seq ID No: 21)


AATTCACTAATGCATTCTGCTCTTTTTGAGAGCACAGCTTCTCAGATGTGCTCCTTGGAGCTGGTGTGCAGTGTCCTGACTGTAAGA


TCAAGTCCAAACCTGTTTTGGAATTGAGGAAACTTCTCTTTTGATCTCAGCCCTTGGTGGTCCAGGTCTTCATGCTGCTGTGGGTGA


TATTACTGGTCCTGGCTCCTGTCAGTGGACAGTTTGCAAGGACACCCAGGCCCATTATTTTCCTCCAGCCTCCATGGACCACAGTCT


TCCAAGGAGAGAGAGTGACCCTCACTTGCAAGGGATTTCGCTTCTACTCACCACAGAAAACAAAATGGTACCATCGGTACCTTGGGA


AAGAAATACTAAGAGAAACCCCAGACAATATCCTTGAGGTTCAGGAATCTGGAGAGTACAGATGCCAGGCCCAGGGCTCCCCTCTCA


GTAGCCCTGTGCACTTGGATTTTTCTTCAGCTTCGCTGATCCTGCAAGCTCCACTTTCTGTGTTTGAAGGAGACTCTGTGGTTCTGA


GGTGCCGGGCAAAGGCGGAAGTAACACTGAATAATACTATTTACAAGAATGATAATCTCCTGGCATTCCTTAATAAAAGAACTGACT


TCCATATTCCTCATGCATGTCTCAAGGACAATGGTGCATATCGCTGTACTGGATATAAGGAAAGTTGTTGCCCTGTTTCTTCCAATA


CAGTCAAAATCCAAGTCCAAGAGCCATTTACACGTCCAGTGCTGAGAGCCAGCTCCTTCCAGCCCATCAGCGGGAACCCAGTGACCC


TGACCTGTGAGACCCAGCTCTCTCTAGAGAGGTCAGATGTCCCGCTCCGGTTCCGCTTCTTCAGAGATGACCAGACCCTGGGATTAG


GCTGGAGTCTCTCCCCGAATTTCCAGATTACTGCCATGTGGAGTAAAGATTCAGGGTTCTACTGGTGTAAGGCAGCAACAATGCCTC


ACAGCGTCATATCTGACAGCCCGAGATCCTGGATACAGGTGCAGATCCCTGCATCTCATCCTGTCCTCACTCTCAGCCCTGAAAAGG


CTCTGAATTTTGAGGGAACCAAGGTGACACTTCACTGTGAAACCCAGGAAGATTCTCTGCGCACTTTGTACAGGTTTTATCATGAGG


GTGTCCCCCTGAGGCACAAGTCAGTCCGCTGTGAAAGGGGAGCATCCATCAGCTTCTCACTGACTACAGAGAATTCAGGGAACTACT


ACTGCACAGCTGACAATGGCCTTGGCGCCAAGCCCAGTAAGGCTGTGAGCCTCTCAGTCACTGTTCCCGTGTCTCATCCTGTCCTCA


ACCTCAGCTCTCCTGAGGACCTGATTTTTGAGGGAGCCAAGGTGACACTTCACTGTGAAGCCCAGAGAGGTTCACTCCCCATCCTGT


ACCAGTTTCATCATGAGGATGCTGCCCTGGAGCGTAGGTCGGCCAACTCTGCAGGAGGAGTGGCCATCAGCTTCTCTCTGACTGCAG


AGCATTCAGGGAACTACTACTGCACAGCTGACAATGGCTTTGGCCCCCAGCGCAGTAAGGCGGTGAGCCTCTCCGTCACTGTCCCTG


TGTCTCATCCTGTCCTCACCCTCAGCTCTGCTGAGGCCCTGACTTTTGAAGGAGCCACTGTGACACTTCACTGTGAAGTCCAGAGAG


GTTCCCCACAAATCCTATACCAGTTTTATCATGAGGACATGCCCCTGTGGAGCAGCTCAACACCCTCTGTGGGAAGAGTGTCCTTCA


GCTTCTCTCTGACTGAAGGACATTCAGGGAATTACTACTGCACAGCTGACAATGGCTTTGGTCCCCAGCGCAGTGAAGTGGTGAGCC


TTTTTGTCACTGTTCCAGTGTCTCGCCCCATCCTCACCCTCAGGGTTCCCAGGGCCCAGGCTGTGGTGGGGGACCTGCTGGAGCTTC


ACTGTGAGGCCCCGAGAGGCTCTCCCCCAATCCTGTACTGGTTTTATCATGAGGATGTCACCCTGGGGAGCAGCTCAGCCCCCTCTG


GAGGAGAAGCTTCTTTCAACCTCTCTCTGACTGCAGAACATTCTGGAAACTACTCATGTGAGGCCAACAATGGCCTAGTGGCCCAGC


ACAGTGACACAATATCACTCAGTGTTATAGTTCCAGTATCTCGTCCCATCCTCACCTTCAGGGCTCCCAGGGCCCAGGCTGTGGTGG


GGGACCTGCTGGAGCTTCACTGTGAGGCCCTGAGAGGCTCCTCCCCAATCCTGTACTGGTTTTATCATGAAGATGTCACCCTGGGTA


AGATCTCAGCCCCCTCTGGAGGAGGGGCCTCCTTCAACCTCTCTCTGACTACAGAACATTCTGGAATCTACTCCTGTGAGGCAGACA


ATGGTCTGGAGGCCCAGCGCAGTGAGATGGTGACACTGAAAGTTGCAGTTCCGGTGTCTCGCCCGGTCCTCACCCTCAGGGCTCCCG


GGACCCATGCTGCGGTGGGGGACCTGCTGGAGCTTCACTGTGAGGCCCTGAGAGGCTCTCCCCTGATCCTGTACCGGTTTTTTCATG


AGGATGTCACCCTAGGAAATAGGTCGTCCCCCTCTGGAGGAGCGTCCTTAAACCTCTCTCTGACTGCAGAGCACTCTGGAAACTACT


CCTGTGAGGCCGACAATGGCCTCGGGGCCCAGCGCAGTGAGACAGTGACACTTTATATCACAGGGCTGACCGCGAACAGAAGTGGCC


CTTTTGCCACAGGAGTCGCCGGGGGCCTGCTCAGCATAGCAGGCCTTGCTGCGGGGGCACTGCTGCTCTACTGCTGGCTCTCGAGAA


AAGCAGGGAGAAAGCCTGCCTCTGACCCCGCCAGGAGCCCTTCAGACTCGGACTCCCAAGAGCCCACCTATCACAATGTACCAGCCT


GGGAAGAGCTGCAACCAGTGTACACTAATGCAAATCCTAGAGGAGAAAATGTGGTTTACTCAGAAGTACGGATCATCCAAGAGAAAA


AGAAACATGCAGTGGCCTCTGACCCCAGGCATCTCAGGAACAAGGGTTCCCCTATCATCTACTCTGAAGTTAAGGTGGCCTCAACCC


CGGTTTCCGGATCCCTGTTCTTGGCTTCCTCAGCTCCTCACAGATGAGTCCACACGTCTCTCCAACTGCTGTTTCAGCCTCTGCACC


CCAAAGTTCCCCTTGGGGGAGAAGCAGCATTGAAGTGGGAAGATTTAGGCTGCCCCAGACCATATCTACTGGCCTTTGTTTCACATG


TCCTCATTCTCAGTCTGACCAGAATGCAGGGCCCTGCTGGACTGTCACCTGTTTCCCAGTTAAAGCCCTGACTGGCAGGTTTTTTAA


TCCAGTGGCAAGGTGCTCCCACTCCAGGGCCCAGCACATCTCCTGGATTCCTTAGTGGGCTTCAGCTGTGGTTGCTGTTCTGAGTAC


TGCTCTCATCACACCCCCACAGAGGGGGTCTTACCACACAAAGGGAGAGTGGGCCTTCAGGAGATGCCGGGCTGGCCTAACAGCTCA


GGTGCTCCTAAACTCCGACACAGAGTTCCTGCTTTGGGTGGATGCATTTCTCAATTGTCATCAGCCTGGTGGGGCTACTGCAGTGTG


CTGCCAAATGGGACAGCACACAGCCTGTGCACATGGGACATGTGATGGGTCTCCCCACGGGGGCTGCATTTCACACTCCTCCACCTG


TCTCAAACTCTAAGGTCGGCACTTGACACCAAGGTAACTTCTCTCCTGCTCATGTGTCAGTGTCTACCTGCCCAAGTAAGTGGCTTT


CATACACCAAGTCCCAAGTTCTTCCCATCCTAACAGAAGTAACCCAGCAAGTCAAGGCCAGGAGGACCAGGGGTGCAGACAGAACAC


ATACTGGAACACAGGAGGTGCTCAATTACTATTTGACTGACTGACTGAATGAATGAATGAATGAGGAAGAAAACTGTGGGTAATCAA


ACTGGCATAAAATCCAGTGCACTCCCTAGGAAATCCGGGAGGTATTCTGGCTTCCCTAAGAAACAATGGAAGAGAAGGAGCTTGGAT


GAGGAAACTGTTCAGCAAGAGGAAGGGCTTCTCACACTTTCATGTGCTTGTGGATCACCTGAGGATCCTGTGAAAATACAGATACTG


ATTCAGTGGGTCTGCGTAGAGCCTGAGACTGCCATTCTAACATGTTCCCAGGGGATGCTGATGCTGCTGGCCCTGGGACTGCACTGC


ATGCATGTGAAGCCCTATAGGTCTCAGCAGAGGCCCATGGAGAGGGAATGTGTGGCTCTGGCTGCCCAGGGCCCAACTCGGTTCACA


CGGATCGTGCTGCTCCCTGGCCAGCCTTTGGCCACAGCACCACCAGCTGCTGTTGCTGAGAGAGCTTCTTCTCTGTGACATGTTGGC


TTTCATCAGCCACCCTGGGAAGCGGAAAGTAGCTGCCACTATCTTTGTTTCCCCACCTCAGGCCTCACACTTTCCCATGAAAAGGGT


GAATGTATATAACCTGAGCCCTCTCCATTCAGAGTTGTTCTCCCATCTCTGAGCAATGGGATGTTCTGTTCCGCTTTTATGATATCC


ATCACATCTTATCTTGATCTTTGCTCCCAGTGGATTGTACAGTGATGACTTTTAAGCCCCACGGCCCTGAAATAAAATCCTTCCAAG


GGCATTGGAAGCTCACTCCACCTGAACCATGGCTTTTCATGCTTCCAAGTGTCAGGGCCTTGCCCAGATAGACAGGGCTGGCTCTGC


TGCCCCAACCTTTCAAGGAGGAAACCAGACACCTGAGACAGGAGCCTGTATGCAGCCCAGTGCAGCCTTGCAGAGGACAAGGCTGGA


GGCATTTGTCATCACTACAGATATGCAACTAAAATAGACGTGGAGCAAGAGAAATGCATTCCCACCGAGGCCGCTTTTTTAGGCCTA


GTTGAAAGTCAAGAAGGACAGCAGCAAGCATAGGCTCAGGATTAAAGAAAAAAATCTGCTCACAGTCTGTTCTGGAGGTCACATCAC


CAACAAAGCTCACGCCCTATGCAGTTCTGAGAAGGTGGAGGCACCAGGCTCAAAAGAGGAAATTTAGAATTTCTCATTGGGAGAGTA


AGGTACCCCCATCCCAGAATGATAACTGCACAGTGGCAGAACAAACTCCACCCTAATGTGGGTGGACCCCGTCCAGTCTGTTGAAGG


CCTGAATGTAACAAAAGGGCTTATTCTTCCTCAAGTAAGGGGGAACTCCTGCTTTGGGCTGGGACATAAGTTTTTCTGCTTTCAGAC


GCAAACTGAAAAATGGCTCTTCTTGGGTCTTGAGCTTGCTGGCATATGGACTGAAAGAAACTATGCTATTGGATCTCCTGGATCTCC


AGCTTGCTGACTGCAGATCTTGAGATATGTCAGCCTCTACAGTCACAAGAGCTAATTCATTCTAATAAACCAATCTTTCTGTA





HUMAN PROTEIN SEQUENCE:hP27-007.3 (Seq ID No: 22)


               MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYMRYLGKEILRETPD


NILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVFEGDSVVLRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLK


DNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQ


ITAMWSKDSGFYWCKAATMPHSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSV


RCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEDAA


LERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQF


YHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSP


PILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCE


ALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTENSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDL


LELHCEALRGSPLILYRFFHEDVTLGNRSSPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITGLTANRSGPFATGVAGG


LLSIAGLAAGALLLYCWLSRKAGRKPASDPARSPSDSDSQEPTYHNVPAWEELQPVYTNANPRGENVVYSEVRIIQEKKKHAVASDP


RHLRNKGSPIIYSEVKVASTPVSGSLFLASSAPHR*

















TABLE 3










MOUSE GENOMIC SEQUENCE:mD27-009 (Seq ID No: 23)



GCTTTGGGGTGGAGGGTCGTGCTGCAGGGAACTCAGCCAGGCCCCAAGATGGACACTTCTGGGCACTTCCATGACTCGGGGGTGGGG


GACCTGGATGAAGACCCCAAGTGTCCCTGTCCATCTTCTGGGGACGAGCAACAGCAGCAGCAGCAACCGCCACCACCGCCAGCGCCA


CCAGCAGTCCCCCAGCAGCCTCCGGGACCCTTGCTGCAGCCTCAGCCTCCGCAGCCTCAGCAGCAACAGTCGCAGCAGCAGCAGCAG


CAGCAGTCGCAGCAGCAGCAGCAGCAGGCTCCACTGCACCCCCTGCCTCAGCTTGCCCAACTCCAGAGCCAGCTTGTCCATCCTGGT


CTGTTGCACTCTTCTCCCACGGCGTTCAGGGCCCCCACTTCAGCCAACTCTACCGCCATCCTCCACCCTTCCTCCAGGCAAGGCAGC


CAGCTAAATCTCAATGACCACTTGCTTGGCCACTCTCCAAGTTCCACAGCCACAAGTGGGCCCGGTGGAGGCAGCCGGCACCGGCAG


GCCAGCCCCCTGGTGCACCGGCGGGACAGCAATCCCTTCACGGAGATAGCTATGAGCTCCTGCAAATACAGCGGTGGGGTCATGAAG


CCCCTCAGCCGCCTCAGCGCCTCTCGGAGAAACCTTATCGAGGCTGAGCCTGAGGGCCAACCCCTCCAGCTCTTCAGTCCCAGCAAC


CCCCCAGAGATTATCATCTCCTCCAGGGAGGATAACCATGCCCACCAGACTCTGCTCCATCACCCCAACGCTACCCACAACCACCAG


CATGCCGGCACCACGGCCGGCAGCACCACCTTCCCCAAAGCCAACAAGCGGAAAAACCAAAACATTGGCTATAAGCTGGGACACAGG


AGGGCCCTGTTTGAAAAGAGAAAGCGACTGAGTGACTATGCTCTGATTTTTGGGATGTTTGGAATTGTTGTTATGGTGATAGAGACC


GAACTGTCTTGGGGTTTGTACTCAAAGGTAGGGACTGTGGTTTCTCTTTATACATTCAACAAAAGGAGTATGTAGACGAGAGAGAGA


GAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGATTGATTTTGAGAGATTTCCTAACTTCCCATGTTTTTCTTCCATGGTCCTGTGA


GAATTCCTTTCTTGCTTCCCTTTGTGGGGACATCCCCACACACTGTGTCTAATGTGCAGACTCTGTGTTTGGGAGGATTAAAGAATC


CCTTCTGAGAAATCGCTCTTTTCCTCCGGGCTCACGCGTACTAAAGCATAACCCAGCAGCTTAACGCACCAATTAATTACACTCTGC


CTTGATGTGTTTGCCAGTTCCTGCTACTTCCCTCCTCGCCTCCCCTCCCTGCTCCACTCCATTCCCCCCCCCCCATAAAAAAGAAAT


AAATGTCTGGGTGGGGGTGGGGATCCTGTACCGTTCCCCAGCTCCCCCCCCCCCCCTTCCCAAGTTTCTATTTCCCTTCTCTTCCCA


GAGAGACTCCAGGGTAAAATGGAGATGTTCCCGAGTCTCTCCCAAGGGCACCGGGTTAAAAATATAGGTGGAGGAAATCAGCAGTCT


CTTCCCTCAGGAAAGAGGACTCAGAATAAACCTGCCGCTGCCTTGTAAACATGCCCTGATAAAAATGGCTACACGTGTTACCCAGGC


AGAGCATGGGCACCGCCTTGCCATCACTCGGGGAACGGGGAGCGCCTCTCCTTAGGATGGGATGACAGGGCTTCCCCAGCGGGTCAC


CGCGGAGTCGGCACCCCAGCTTAGCCCTGGTTCTTCCCTCCCACCCTAACTCCTTCTCCTTGGGATAAATAAAGATGAGTGTACGTG


TGTGTGCACGCTGGATGGAGAACGGCAGGCACAAGGCACTGTCTTGGGGGTGGGGTGGGGTGGGGGACGCTCCATTGCTCTATCCTT


TCAGTTGGAGGAGAGAGCTTCCTTCCCAGAGGGGAAGGAGGTCGAGGAAGGTGGGTTTTTGTCAATGCTGCATTTGCCAGGAAGCTG


CATGCCAGAAGGCTTGGAGGTGCAGGGAATTGTTGGGCAAACGGTTTCCCCTACTGTACCACTTGGTCCCAGTTTGCTGGTGTTTGC


ATGTGTATATGTGTACTCGTGTGAGTGCCTGCTTGTTCTGTGTATTTGTGTATTTGTTTGTCATTTTGGACAAGGGGTGGCTGGGCT


GGCTGGCGGGTAGCTGGGAGGGGCTCAGCTGTTGGAGGTTTCAAATAGAGCCTGTTTCAGGCAGCGCACAGCTGCTGGAGACTGTCA


CATTCCTTGTAGAGATCTAGTCACAAAAACCTGGGAGGTGCTGATCAGATTTCCCCCATTCCCAGAGTCTCCCTTTAACCTGATGTG


GGCAGTGCTCCTTGTCAGGCAACCTGCATGGACAGAGCCCAGACTTCCCAGCAGAGAGTCCTCCAGGGACCTGCTGCTTTGCAGGGA


CTGCCCAAGCCAGAGCACTTGGAAGCTGCCTCAGTCTAAATAGCTCCTGGATGAACAGACCTCTCCATGAGCAGAGTGGGGTTTCCC


CTGGAAGCCCAGCTCACTTAGTCATTCCCTGTAATGAGAGCCTGGGAGGCTGCAGGTCCCTCTGTTCCCTGCCTTCTTAGAGCTGCC


TCTCTTGCTGTGTGCTCTGCTTAGGAGATGGGCTGGCAACCCCCCCCTGGGAATTAGGAACACTTGTTAGGGGGAATCCGTGGAAGC


CCACATCCCGGAGGTGTGGCATGGTGCTAGCATGTTCTTTTCAGTGGCCCCCATGGCGGCTGTTAAGGAAATGGCTTTTCTAGGAGT


CAGTGGCTGTGTCCGGCTCTGAGTGTGGGATCCATGATCATTTGTCTGAATGTGTTTTGGGGGTAGGGTGTCACCGGGCAGGGACGA


CTATCTTCTCTGATGGAGAGAGGTTTTCCCGGGCCGGGAGGCTGTAAGTGTTGACTGGGTGATATCACCCAAGGTGTGTGCTTCCTC


CACTCCTAAGTCGTTGATTCTCTCGTGGCGATGGTACTGAGGGACAGTGACCAGGAAGCTCCTGCGTGCCTCAGTCAGTGAGGTGAC


CACTTCCTGTGTACCTCGGGGATGGGATTGAAACAACAAAATGTTTATTTAGTGAGGCAAATGTCCCTATCTACCTCGGAGGCAAAG


AGGGTCATATCAAAGAATAGGACCAAATCAGGAGTTACAGCTCTGTCACTGCTGGCTGTGTGATTCTTGGAAGTCAGGATACCCTGC


AAGGCTGCTTCCAGCTTTCTGGTGGGGAGACTGAGTCAGATGAGGTCAAGGCCCACCAGAGCACCTGCTCATGTAAGAGGGGTCGGC


TGTGGCTGTCTGTGATGACTGAGGAGAGAGACACCTTCTTTCTCTGTGATTAGATGGAAAGTAAGACGCAAGGACAGAGGAGAAAGT


TCTACAAGGAATCTGGGTCTGGTTGGAGACTGTCTTTACACATGAGGCAGCTGTTGGGGAGAGAGGTGTCAGCTCCCCAGCTTTGGG


ATACAGGGGGATGGGCTCTGTGACAGAAGAGCCCAGAGACACTCAGGGTGGATGAGGGACTTTCCTTTGCTAGGATTCTTGTGTGCC


TGCCTGTCTTTGCTGATGATTCTGGAAGCCCGAGGATAGACCAGGTGACCAGTCATTTTGGGTACCTACCATGGCCATTTCTATTTA


AAGGCCCTGGTGAGGGACAGGTTCTTTTTCCTCTGAGTGACTGATGGCCTGCAGCCCTGGGCCTTACCTAACTCTGAACTTCTCTGC


TTTATCTCGTGAGGCCGTACCTGCCCCGTCCACCTACTGTACCTGCTGCTGGGAGAGTCATTCATCGCATGATGAATGCAGGTCCAG


GGGTCTGGGAGAAAAGCAATGGGGCAGATACCCTGAGTGTGCTCAAAGGTGATGCAAAAGGGAGCCAGCGTGAGGAGGTTGAGAAAT


GGGGACAAAGTGCTTCCTGGCTCCCACCCTCACAGGCTGTAGGCGATGACACTGGCGGGAAGGAAGTTCCACTGAGAAAGGAGATGG


AAGCCTGACTTGGGGAGGGGGGCGTTGTGGACCCCTAAAGGTGCAAGGCTGTCTCTGAGCTGAATGGAGGCTCTGGTTTATCCATCC


CTCCCTCCCTTCCTTCTCTTGCTCCTCCCGTTCTTCCCTCCCCTTCTCATCCTCCCTCACCTTCCTTCCTTTAGTAGGTGGGCTTCC


TCTTTGGAAACTTAGACAACAGGAGAGGGCTGATTCTCAAGATCCTGTTTGGAAGTCTTGATGATCCCGCCTCTGCCTATGGCTCCC


TCTAACTGTTAGAGTCTAACAGGGTTAGGGGATGGGGATTTAGGTTGTTTTTTTTTTTTTTTTTCTGACTGTGTTCTTTAGTTTTTT


CTGGAGCTGGTTTGGCCCATGTCACCCTTTTACCTTAAGCTGTCAGTAATTCTCTACTAGATCCAAAGAGTTAGGGGTAACCTGGCC


TGCTTTCTCTTCCTTAACACCCTGACAGGACGTCAGGCCTCAGCCTGTGGCAGCTTCCTCAGTCTGGGCAGCAGGGTAGCTGTCTGT


TTCCACAGATTTTGTACAGCCTCCGTAGCTCTCCACTGCTGGCCTAGAGATCCATTTCAGCCTTACCTCTGCTCCCTTGCCCCTCCT


GCCTGCCCAATCAGACTTCCTGTCCTGTTCCTTTCTGATACCCCAGCTTGACCTGTTGCTAGGATGAAGCAGTCACCGATACAGAAG


TCCCTATCTGCTTCCTTGGGTACATTCTCCTCACTTCCTGTTACTGTTCCTTCTTCAGACCACCAACTGGGCCGCCACCCTGAGCTA


GGTCTACTGAGCAGCTAAAGGAGGTCCCTACTGCATACTCTCCAGAGAATGGTGGCTTCTAGGCCTGGGCCAATTTGTTGCCTATCT


CTTTGCTGGCCTCACATATATCATAAAGTCCCCCCAGCCTTCAGCTGGAATGATGGATTGTATTCTAGGCTTTTATTTTTGGTCTTT


GTAGGGTGTGTGTGGGGAGGTGGTAGCCACAGCTTCACACCGTAGGTAAACATTCTACCGAGCTTGTCTCCAACATCCAAGATGCAT


CTCTGTCCCGATCCTCTGCCTTCCTGGGATGGAGGCCCTAGTTGCACAAGGACAGAGTGGTAGCCAGGGTACATAGGATGAAGGACC


CTGCTTGTCTCTTTGGGGCCAAGTGCCTTCTGAGGTTAGGTTACTGGTTGCTGGAACATGTATTTCTGGAGGGTTTTGGGGGGCACC


AGTAACTATGATTTCAGGCATGCTGGGGAGGTAGACATAGGTCAGACCCTGGTGTGCACCTCCTGAAGGATGTCCTCTGAGAATAAG


AAGGCAGAAGACTCAGTAAAGCACTTTGGCTGCAGGACCCTGAGAGCCAGCAGCCAAGGGCCCCAGGCCTGCATTTTAATTGTCACA


GGGTATACTGGCCATGCCTGCCCTGGGGAAGACAAGCAGATCTGATAGTATGAGACAGCCAACCCTGCACCCATGGTGACCCTTTAT


TTATATTCCTTGTGGACAGTGAACTAATGAGTCAGATCTTGGTAACCTATAGGATTACCAGTAACTTGTCACCTACTTTCCTTCCCA


TGTCACCCACTGTTTATAACTGTCCTGGGGACAGGCTCCACAGGGCTTCCAGACTTCCCATCCCCACAGGCAGCACTGGGCATTGGG


ACAATGGCTGGGCATTTGTCTTCTGAATAAGCTAATTAGAAAGCTACTCCATGGCCTTTGATTCCCTTATTTAGCTTCCAGGAAGGA


GGATGTATGAGGCCATCCTCAAAAGATTCCCTTAAAAAAATTAGGTAGAGAAAAGCAGAAGAAAATTGGAGTAACCTGTGTTGTGAC


TCAGGCTCCAAGGCAAATGTAAAATCAGAACAGAGAGCTCTGGTTGCATGCCAGTTACTTATGAAGCACACTGGGGGGAAGTGTGTG


TGTGTGTTGTGAGGGGCGGCTGTACTGTACTGTACTGTACACAATATCCCCTTTCTTTGCGCCATGACAGGACCACCAGAGCATTCG


CTGGGTAGTTGTTTTTCTCTCAAAACCCCAAAGGGAGAGAGAGAGAGAGAGAGAGAGAGGGAGAGAGGGAGAGAGAGAGAGAGAGAG


AGGGAGAGGGAGAGAGAGAGAGAAGAAAGCCATCAGTTCCTCTTTAAATAATGAGGGTTGGTAATTCTAAGACTGCTCACTCTCAGG


AGCCGTGGGGAGGAAAACTCGAGTGCCTTTTCTTGTGTGGAAAGTCCGGAGGAGGCTAATGGGTTTTCAAGGCCCCCTCCCCTTGTC


ATTCCACCCCCAGGTGCTCGGGAGGCAGGGGAGAGGCTGGGGGCAGGGACCACACTGTTTCTTTCTGCCCCACACTGCTCCTGCGTG


AATTGCTGCTGAGTGACAGCTGAGGGAAGGCGAGGACCTTTTTCTTAAGAACTGGATGACTTTACACCCAAGAGTCCCAGAAGTAGG


TGGTGCTGGAGGCATCCTATGCAGATGAAATCACTCACTAAGCTAACACTGCCAGTGGGCGTGGTACTGAGATAAGAATCCTGCCCT


TTTGACTCTAAGTTTCTGTGCCTGCTGCTGGAGGCCTTGCTTACATTCCTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT


GTGTGTGTGTATTTGTGTGTGCCCGCATGCGCGTGCGCGCGCGTGCATATATGTTTCCAGTTTGGAATTTCAGTGCAGAACCTTGCA


CCTATTAGGTAAACAGTCTGCAGAGGAATCTCCCCAGCCCAGATTGCTTATACTCTGTTTTGGTTTTGTCCTTTTAGATTGCTTGCA


TTTTCTCTGCATGTGCTGTGTTATATGTACATGTGCATATAACATGTGTGCATGTGGCTGGCCTGCGAGCTCAAGGGCTCTCGTCTG


CTCTCACCGTATCCCATCTACCCCTGTATCCTAGTTTTCATATGGATACTAGAGATTGAACTCAGACCCTTGTGCTTGCATGGAAGG


TGTTTTGCTGACGGAACCATCCTCCTGGTTCAGCACCCCTCCAGCCTCTGATATATTCTTGGAAGAAACAGATCAAAATCTATGGGC


CAGAGACCAGAGATACAAAATGTCGGGCTAGAAGAAGCTTGGCCAAGACATAGGCAGAACACGATTGGGATGGGAGCTGTTGGTGCA


GGGACCCAGACCAAAGGTTCTGTGGTGCAAGCAGCTTCCTGGGGGCAGGCAGTCTGTTCATTGAGGTGGACGGAAGGCCCATGGTGG


GTCCCTGAGATGTTTCCTCTATGGGGGGGGGATGTGGCCATCCACTGTCAGGGTGACTCTGAATAAATTGTGAAGAAGTAGTTGTGG


GGATTACAGGGAAAGTGAGCTTTGTATAGGTTTGCTGTAGGTACCTACCACAGCACCATTGCCCCGCCCCCAAGCCACTGTGCCTCC


CCCTCCCCTCCTGAACTAGCTGGCTTACCTTGTTCCCTCCTGCCTGGATCTTCTTTTAATTTTCTCCTTCCTTTCTAGTGCTAGCTG


CCGAGGTGGTAATGGGGAGTTGGGGATCAGCATGGTGTATCTCQCAGGCATAGTCCAGCTGCCGTTTCGCATGGTCCCCACAGTGGT


TCAGGATCGTTACAACCAACAGTACTTTCCAGCTGAGAAAATCGAGCCATCAGACCCCCTTCTTAGATGGTTCTAGAAGGAAGCTCA


GAGCTGAGGTGCACGACTAGCTTCTATTTTAATTTTCATTTCATTTATTTATTTCCAAACCAGAAAGCTGGGAACTGAGTAAGGAAG


TCTCTGAGGGCTTTTCCATTGCTATTCTAGAATTTTCTTCCTTCTGGAGTTCCTCCTCCCCCCCTCCCCCCTCCCCCTCTCTCCCGG


CTCTCTGTGCCATCAGCATAGCTGGTGCTGGAAAGGGTTCGTCTTTGCCTTTATGGCACCCTAAGGAGGTGCTGGTACTCGGTGCTT


CTTGCGATTGTTCTTAGCTCACTTAAACCTGAGACCTGAGCTCTTTTTCTGCCTCCAGGTCTTGTCCTTGTTCCAAGGACTGTCTGA


GCCACTGTTCTCAAAGCCATGCTCATCAGAGGTGTCCCTCAGTCAGTCAGAAGGCCAGACAACGTCATCCAGTTTGAGAGGAACTTG


GGCTAGCCCTGCTGGAGGCTCCCTGTAGAAGGTCGGGTAGTTACTGAAGGGTCAGATGAGCCATTGTGGAAAGAGAGACTCATTTCT


GTAGGACAGGGGGACAGAGGATAAAGTGTGTGGGAAATGCAATTTATGCAGATATCTTGAAGATGCCCCAGGATGTGCATGCAAGGG


CAGATGGGAGGAAAGAGAAGATTGTGAGAGTTATGGGGGCTGTGCTTCTCCTGAGAGGTTCTGAACAGGGATCAAAACACTCCTGCC


AGGGGTGTGGGTTCAGTGATTGACTTAATAGTGAGTTGCCAGGAACTCTAAAGATCCAATGCTCTTTTCCCCCTCAAATATGATCTT


ACCTGTTACGGATGGCCTAGTATGGTAGCTAAGGGGTTTGCATCTAAGTTTATTTCTTAACTCTATGGCATACCTGTGGTGGGGAAT


TTGCTGAACCCTGTTTCTTCATATGGGAAGAGCGAACTCCAAGCCCTCCTTAGATCATAGGACTCAACACTTTTCCCTGCAATATAA


CATCTAGAATCCTTCCCTGTACCATAGCATGCAGCATCCCTCTTTGAAGCACAGTCCGTAGCACTCAATACTTCTGTCCGTATTGTA


GTACCTAGCCTAGTGAGTACCCTGCAGTGCAGCACTGAGCTGGGCGTGCATTGAACTTCAGCAGCTGCCAGATGTTGCTTTTATTGG


ATGCCGCTTGGAGGACTGAGCCTGGAGGGACACAAGTACACATGTCCCCTGTGTATGCTTTCCAGGTGGTTGTGGAGAAGAGAAGAT


GGGCTTCAGGTTAGGAGAAAGGACCCTGGAAGAGTTGAGCACACGGGACCTTGCCCTCATTCTCAAGAAAAATGGACAAGCCACCCA


GTGTTACTGCTGATAGGTCTCAGTGTGTAATGAGAGGAAGGGCTACTCTTGGGAAGGCGGGACTCTCATGATGGCTTGGCCTGGCCT


TCTAGAGTCTCCTATCATGAGTATATTCAGGGTTGGCAGTCTGTGGCTTGGGCATAGCTAATTGGGTGTAGGCATTCAAATCGGACA


GGTGGAGAGAGCACAAAAATAGACCCATGGGGCCAGGCCAGAGGCTGAGAGGAAGGTCAGGGGGACACATGATGATCAAGCAGAATG


AGATTGAGAGCTTGGGACTCTAGGGCACGAACTAGCCCACAGACAGATCCAGGCAAGTGAAGACTGCTACATCTTGCAGAAAGTTCC


ATCAGGAAAACAGTTTCCCTTCAAGACCAGAGACAGGGATACTTTGTATAACTTAAAAGGTTCCAGCCTGGCATGGTGGCACAAGCC


TTTAATCCCAGCACTCGGGAGGAAGAGGCAGGCAGATTTCTGAGTTCAAGGCCAGCCTGGTCTACAGAGTGAGTTCCAGGACACCCA


GCTCTACACAGAGAAACCCTATCTCAGAAATTTAAAAAAAAATGGTTCCTCTACCTCTTTTACCCTGCTTAACACTAAGGCCATGTT


CCTAGCCAGGCACCAGGGGGCACCAGCAGTAATTGGGTGGCGGAAGCTATGCCAGGGAACCTGGACTTGCTGGGGAGGAAGCAATTC


CTCCCATCCCAAGTCCCTATCCCAAACTACTTGAATTATATTCTGAACAGAGCCTTGGTGATTCAGGCAGAAGATGTGTGAAACAAT


ATGCAAATTGGCATCTGTTGTTGTGGCGTCAGGTCGATGGGCATTTTTCTTAAAGGACAAGAAGGTCGTTCAGATGTCAACTGAGCA


TGAACATTGGCTTAGACGAAGCTTGGGGCAAGCTTGTTGCTGAATGGGCTGGCGCTTGGACGTTGGAGCTATAGGTTCTTCCTCTGC


CACCTAGCATGTTCAAGGCTAGTTATTCGGGGTTTAGCCTGGAGAAGTCTGTAACAATGAACACCTTGCACAGAGGGTCACCCAGCA


AAGAGGGAGGAGGCTGGAAGATCATCTGATCTCCAGAGCCCTTTCCTAGTGGGGAGCTTGGGACCGGAGAAGGCTGCAGGGAGTCAG


GACTGCTCTGGGTTCTAACTATGGCCTACCCTTACTGCTGAGTCACCCTAAGGACCATGACTCAACCTCTTTGAGCTTCAGTTTCCC


CATTTGTAAATGGGAATACTGACATTCACTGGCCCAGTGAGACTCTCATTTGGTGATAGTTCAGTAAGTGGCCAGCGCAGTGGCTGG


CTGACACCTTTCCCAGGCTGGCGGTTCCTCCTCACACCTTCGCCTGAGCTGCCACCTGCCCACATTCCAGCGAGGTTTTACTAGCAG


GGCTTTTTTTTTCCCCCCCTGGGCCTTCTCTCCTTTGTGAGGTTTCTGATGTTAACAGATTTTTTTGTTTTTTGTTTTTTAATCTAT


TCTGACTTCCAGCGGGTGAGATGCTAACTTTTCACACAGATCTTGCACATGGAGACATCTGGAGCTGCTGACAGAGGTGCTGTGCCT


TCTCATGTTGAGAGTGTGAGAGTGATGCCATGGTTTAGGCCACCGTGTCGGGAGGGGCTCGGACCTGGAGGCCATTGGGAAGAGGAC


CCTAACAAGCCTTCTCTGGGGATAGCTGGGGACATTCCTGCCTTAGGTAGCATCCACCAACCTGGGTGGGCATGACTCCTGCACAGG


GCCCACTTCCATGAGGAAGGCAGGGCATGGAACACCGGTCAGGACCGCAAGGTTCAGAGAGGTTATGTGAGTTATAGGACCGCAAGG


TCCAGAGAGGTTATGTGAGTTATCCAAGAGCACTAGAGCATTGTAAGAAGCAGGGTACAGCAGGAACCCAGGGATTCTGGGTTTTGT


CCTTTCTTTCTTTCCCGTTCTCCTACCCTTCTCCAGGCAATCTAGGTGCTAGGAGGGGAAAATCTGTGACCTAGAGGATTAGAGCCA


GCTCTGTCTGGGGTCTCTCCTTACCACTACTCTCTGCCATCTCATCTATCTATGTATCTTTCTCTGTGTCTATCTCTGTATCTTCCT


ATGTAGGTATGTATCTCTGTATCTATCTACGTATCTACCTACATATCTACCTATGTATGTATGTATGTATGTATGTATGTATGTATG


TATGTATCTATCTATTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTTCTATGCCTCTTTATCTACCTAACATGTATG


TATGTATCTATGCATGCATGTATGCATGTATGTATGCGTCTATGCTGGGAAATCTATCTATCTATCTATCTATCTATCTATCTATCT


ATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATTGTGAGAATTGAACTCAGGACCTCTGGAAGAGCAGTCAGTGCCCT


TAACTGTTAAGCTATCTCTCCAGCCTGCCATCTCTTCTTAAAAGTGCTTATGTGGGAGACAGAGGCAGCAGATTTCTGAGTTTGAGG


CCAGCCTGGTCTACAGAGTGAGTTCCAGGACAGCTAGGACTACACAGAGAGATCTTGTCTTAAAAAACAACAAAACAAAACAAAACA


AAACAAAAAACAAAGCAAAGAGTGCTTATGCTTTCCCAGCTTGGCAGCAGTAACTGATTGCTGAGCTGGCTGGCTTTGCAGAGCAGA


AGATAGGATTTTTAAATGCTTATTTTTTAATGATTTATTTTTATTTTATATGCACTGGTGTTTTGCCTTCATGTGTCTCTGTGTGAG


GTCTTCAGATCCACTGGAACTGGAGTTACAGACAGTTGGGAGCTGCCATGTGAGTGCTGGGAATTGAACCCCGGTTCTCTGGAAGAG


CAGCCAGTGCTTCCAACCATTGATTGAGCCATCTCTCCAGTCACAGAAGGTGGGATTTTTAATTCCTGTTGTTGAGGGTAGCGGTGG


ACTAGAAGTGGATGAGGCTGGGGATGAAAATCACTGGTCTGTTGTTTACCTGACTTATTCAAGGCACTGGGTCTCATGTCCAGGATG


GCAAGGAGAATGTGAGCAGGCAAGCTGGACAGGCATGGCCTCTTAGGGCTCTGGTTCTTGGCAGTGATGACTTTTGCCTTTGATGTC


TGTCCTGAGAGTCTGTGGCCTTTGTTGGCCCGTGGTTCCCACTCCTCCTTGGTCCAGACTGCTATCAAGAATCCTGAGATCCCTCGG


GAGTGAATGGGTGGGAGCAGGGAGTCAGACTCGGATGTAGGCTGAGTCGGGAGGGTTTCATCATGGGCAGGTGACATCATAGACAAT


ATTTTTGTCCCCGCAGCTTGGGAGGGTACCCCACAGTCTTGAAGCAGATGCTTCCTCTCTCTTCCTTGGAAACAATAGGAGGCCAGT


AGGATAACGCAGGCTCAGAGGACAAAGCTGCTCTATGCCAAGGCTGACTATCCGAGTTCAAACCCCAGGTCGGGGAAGGAGAGAACT


AGTTTCTGTAAGTTGTCCTCTGACCTCTACATACTCTTCCCTAAATGAGAGAGAGAGAGAGAGAGAGAGAGAGAGCGAGAGACTGCA


AGTGGGTATGGGTATCTAACTCTGATGAAGAGAGGAGACAGAAAGGAGAGAAGACAATGAATATTTCCAAAGGGTCTATTCCGTGTC


TTCACATTCCTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNTCCTTTCCTTTCCTTTCCCTTTCCTTTCCTTTCCTTTCCTTTCCTTTCCTTTCCTTTC


CTTTCCTTTCCTTTCCTTTCTCCTTCCTTCCTTCCTTCTTTCCTTCCTTCTTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCC


TTCCTTCCTTCCTTTCTTTCTTAGTTTGTTTGCTTTTTTTTTTTTTTTTTTGAGACAGAGTTTCTCTGTGTAGCTGTAGTTGTCCTG


GAACTTGCTCTGCAGACCAGGCTGGCTTTGAATTCTGAGATCCATCTGCCTCTGCCTCCCAACTGCTAGGATGAAAGGTGTGCAACA


CTACCCAAGAGTGTGTTCTTTCAAGCCACCCCCCCAAAAAAAACCCTATTCAGTCTGTCAGTCTCACCTGGCTCATTGTCCCCTTAT


TTTCCTTCTTATTGGCCTGCTCACCTGACCCGACACCCCTGGGGTGTGCGGAGGGGCAGGCAGGGTGCTGTCAGTGTGATGCATAGG


TTTGTGGGAGCTCTGGGAGCCAGGTACAGGGAAGGTTGGGCTTGGACATCCTTTGAGTTTCTCTGTCCCGGCTCTGTGACTCTGTGA


GTCTCAGTCTCTAGGTTTACAAATGAGGACAATGGTGTTTTCTCTCTAAGAGAGTGTGTGTTGTGATGGAGACAAGATGAAGAGAAG


GCTTTGGGCAGGGCATGGTGAGTGTCAAATAATATCACATCAATAATGTTCTCAAAATCGACTTCCAAACCTGGCTTTGTTGTCCCC


TCACCTGAGGGCTAGGATGGGTTCCGCATCTTTCCTCCTCCAGGCAGTCTTCTGGGCCCTGTGTGCCTACCTGCTATCCTGCCACAG


GTTAGGTGAACTCTCCAGATCTCAGCCCTGTTTATCACTTGCTAGCTTTAGGAAGTTGCTCTAACAGATCGACTCGCAATGTTCCCA


GTGGTTCCTGGTAATCTGTCTGTCAGTCTTCTGCAGGAAAACGCCAGGCTGCTGTCAGTAAGCTTGTGACATGGCTTTTGCCATACC


CTGGGCTCTCAGTAAGGGTCAGCTGAGATTGTGGCGGCTGGTGGGAACCTCTCTGGCTAGGCATGGCCAAGCTTGGCGGCTGGCCAT


TTGTTTGGTCATCTGGAGAATGGAGCAGGGAGCTGGAGGAGTCTCCTTCCATCTTAGGCTGGTGACCACATGGAACTGGGGGAATGA


ATACTTGAAAATGGCAGTGCTCTGGTGACAGGGCACTGCCTGTCAGTGAGTGCAGGGTCTACTGGAAGAGTGGGTTGGAGGGTTATC


TTCATGTCCCATGTGTGAAGGTAATGCAGCTAAGTGGATTTCCTCACTATCAGGAGATGGCTGAGAGACAGGCCCTTTGGCCAGCTG


CCCTCCCTGCTGCCTCCTCCCCGCAGGCCAGCCCTTGGCATGAGGCCTGCTTGTCTCCTGAGCCCTCTGCGCAGCAGGGATTTAATT


ACTATGATGTAAGGAGCCCAGGCTCGAGGCTCTGGCAGAGGCGAAACAGATTTGTCTTCTTACTGGGAGAATAAAAACGGACAGAAC


AGAGAGAAATGACTGTCCCCAACCTCCCCCTCCCCCAGAGGTTCCAAGGCTGTTGAGCTGATGGGGAGATTTTTTAGGGGATAAGGG


GGGAGGAACAGGTAGCAGTGTGTGTGGGGGGGCGGGGCAGGTGCAGGATACCCTGTTCAATTCAGAGCCTTTGCTATTCAGTTTTGC


CTTCTATGACTAATTCAGCTAAGCTGCCTGTTTTCCCAAAGACTGGGCAACAGCCTCCATCAAGTACCTACTATGCGCTAGATGTTG


GCCTTGAGAAACTTCCTGTCCAGGCAGGAAAGCATGTGTTTTTATGCAGCCAACAGATGGCTCCTGACCACCTGTGAGGGGCCAGCC


AATTATTCTAGGCACAGCACAGTAGGAAAAACCACAGTAGGCCAGAGTCTTGCCCTTGGGGATGCACATTTCCATAGCTGAACCCAA


CAGTAAAAGATATCAGCTAATTATATATTGTGTTTGAAGTCCTATGAAGGAACAGAAAGCTGGGCTAGCAGGACACGGCGTTCCACA


GGGAAGCTAGTCATCTCGAATAAGTGCTCAGAGGAGGCCTTGATGAGAAGGTGACATTTGGTGAAGGTCTGGGGTTGGTGAGCAAGC


CAGGCTTCCTTGGCCATGGAGGTGGGGACTAGCTTCTCCAAGGCCTTCGTCAGGTTTGTGCTTGCTGTGGTCTGGATAGTTCTGTCC


AGTAGACCTAGAACACGGAACTATCTTGGTCCTTTTATGCTTCCTGGTAGCTGTATATTTTTAAAAGTAGGACATATGAAATTTGTT


AATATGTTCATTTCATGTGATGAAGAAAAATATTACAATTTCAATGCGTAAGCAACATAAATATTTTCAATGAGACATTTTCCATCC


TATCTGCCATGCTATGTCTGGTGGATATCTGATGGCTCATCTCAGCCAGCCACTAAATCTTCATTGGAAACACTTACCCGGTTTTAG


AGTCCATAAAATTTATAGTTAAATAAACACTCACGTTGTTGCAAGCATACTTTAGGAGTTTCTAATAAATTAATGGTGAACCAGTTT


AGAATTTATGGTTATTTATTTTGGTACTAGGGGTTGAACCATGGGCTTCACATGCGCTAGGCACATGCTAATACTGCTGAGCTATGT


CCCCCACATCCTGGTACATCAGTTTTCAGATGAATGATTAATAACAGAATGTACACATAAATTCCTCACCCTCGCCATGTCAGTGGG


GTGTGGTGGAACGTGTGGCATCCATCAGAGACTCCCCAGGAGTGAGGAGCCCCTCCCTCTGCCCGGCTGAGCATAGGGAGCACGGGG


ATGAAGCCAGCTTGGAGGTAGGACTTGGAGTGTTCTGTGCAGCACTTGCCCTTTACCCTGGCAAGATGGCATCAGGTGAGGGCTCTG


AGCTTTGGTATTAGAGTTAGGCACAGACAGGGAAGCCTCACCAGAGGTTTAGGGACACTTCAGGTGAGGCTGGTGGTGATGGAGCAC


CCAGGTGGGAAGTAGCAGCCAGGTGGTGAAAGTGGGTGGTCCTCGCAGTGTTTGGAAGGGTAGGTAGGCTTCTGGTGTGTCTGCTGA


AGTGGGGGGTGGGATGGGCAAGGGGTAACCCTAGAAGCTGGGAGATTTGTGAGACCCACACTTGGGTTATACAAGGTTCTTGCCCAG


TCCCTTTCTTTGGTGGACGGCTCCCCTTGCATTCCAGAAGACAGTTTGGGACAAGGCTGGCATCCTTTCAAACAAAACCAAGGGGTG


GGCAAGATAGCAGATCAGGGTCAGGGTTCTTATGGCTAAGCCTGTTAACCGGAGGCGCCCAATCCCTGGAACCCACATGGTGGAAGG


GGAGAAGGGACTCCCTCGAGTTTTCCTCTGACCTCTACATGTGTGCCTTGGCGTGGCTAAACCCCCAGCACCACAGAATAAATAAAT


ATTTAGAAAAAATTAAGAAGGGGCTGAGGAGAGAGTTGCACGGGGAAAGCTTCTGTAGTATGTGTGTGAGGACTCACCTTTGAATCC


CTCCCCCCAAAAAACATTGAACCCATATAAAAATGGATGCGGCAGGGTGTGTGTCTGCAATCCCAGGGCTTCTGAGCGAGGTGAGAA


TCAGAGACAGGAGACTCCCTGAATGCTCACAGGCCAACCAGCCTAGCGTGTGCAGTTGTGAACAGCAAAGAGATTCTGTTCAAAGGA


AAAAATGTGGCATGGAAGAACTACGCCCAAGGGCCATGTGCACACCATGCCCCCCGCCCCCAACCAAGAAACAAAGCGGCACACACA


GAACCCAAAGAAATTATCGGTGCTTACAGTGTGATTAGTGTTTAGTTCCCAAAGGTCACAGGAATCTAATAGTCAGTCCACATTTGA


AGATCAAGTCTCCCTGTTCTGGGCTGACCCCAGAATGCTTTGATGGATAGGGTCAGAAGTGGCCAGAGATTCCCATGGTATGACCAG


GAGATTACTGAGATAAGATGGATCCCATGGATTCCTAGTGTTCAAACACTTTCAACTCTGTGGGCAGTGTGTGTGTGTGTGTGTGTG


TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTAGATCAATGAGCTTGAAAAGATAGCTCAGAGGTGAGGTCTAGGTGTTGGGAG


GTGCCAGTCTTCTGCTCACTAGCCAAACTGCTATGTCCAAAGCCCGTTGACTCTCCAGGGCTCTCAAGGACCACAAAGCCATGCCAC


TATAACTGTTTCCTTTCTAAGTGTGGAAAGAGCAGGGATGGCTTTAGATGTCTTCTCCTGATGTCTTGATATCTGATGGTTGGCCTT


GGGCCCAGAAGGTGAGGGTCTGAGGCTATGGGACCTGTGGGCCAGCTCCTCTCACTGGTCAGTCAGATATGCTGGGTGTGGGTCTGC


TGCTGCATTCAGAGTTGGTCTGTGCCACTAGTTGACCATATGACTTTAGTACCTAAGTCTTCATCTGCGTTTGCTCATTTTGTGGTG


CAGGCAAGGGTGATGTAAATAGATTGTGGTGATCCGGCTCAGTCAATGTTGACTCCTTTCTTCTTCTGTGAGGTACCTCAGGAATAC


CTCACACAAGCTTCTCTGGCCTTTGGTGAAGAGAGACAGCCTGTCTGGGGTGGGATGTTGATGAGGAACAAGAGGCAGGGGAAGGTG


GTGATGGGGAGACCTGGGATCTACCTGGCCTGTGAGCCAAGGCTTTCCACCTGAGGTGCTTCTCAGAATACATGTAGCAGAGTCTGG


AGACTTGGTTGGTCATCACAGCCAAGGGAAGGATTTGATAGATACCTAATGGACAGGGGCCAGGAATACTCACCAAATCAAGGTATT


ACCTGGTTCCAAACAGCAGAGACTGGAGAAGCCTGGATAGATGGCTTGTTACAAGGACAAATGGAAGGATGAAACCGTCATCCTAAC


TATAGCATGACACTAGTCATCTCTGGGATGCTGGACTAGGTGGGACTCAAAACTTCCATTTTATTTTGAGGGTCTCACTATGTAGGC


CCCTGCTTGTCCAGAACTTGCTAGATAAACCAGGCTGGCCTCAAACCCACAGAGATCCACTTGCCTATGCCTCTCAATAGCTGGGAT


TCAATGCATGTACAACTATACTAGGCTCTCAGATTTGAATTCATGATCATGTTCAAATTCATGTTCAAGTTCATGCCCCTCCAGAGT


TTTTTCTTTGTTTCTAATCTCTGTGTCTTTACATCCTTCACCTTGGAGGTTTTATCTGTAGACGAGGCTGAGGTATGAGCCACATTA


GAGCCTGTGAGAAGGTGAGACTTAGGGGCTTTTCCAGGACTTCCTCTTACCTCCAAGAGGCCTCATATACTGGCCCCACTTTATTTT


GGTCTTTTTTAAAAAAATGTGCATTGGTGTTTTGCTTGCGTATGTGTCTGTGTAAGGGTGCTAAACCCCCGGGAACTGGAGTTACAG


AGAGTTGTGAGTTGCCATGTGGGTGCTGGGAATTGAACCCAGGCCATCTGGAAGAGCAGCCAGTGCTCTTAACCCCTGAGCCATCTG


TGCAGCCCCACATCTCCGTCTTTGTTGTTTCTGAGAATGAGTAGAGCTGAAGTCTCCATTTAAGAAAGAGGGGATTTTCAGGGCTTA


CGACTCTGTGAGTGGGAGACTCAGCTGGTTTAGTGGCAGACTTCCCGGCATGGGGAGAAACAGTTGGTTTGCCAGCTTGGGTCAAGC


TAGAAGCCATTTGAGGTTGTGTGGGTCACTGCTCTCTAGGTCTACCTGGGGAAGCAAGTACTTGTGCTGAGTTGCCGACCGGTTCCT


GGGGAAGACAGATCTAGGAAAGGTCTGTGGACTTCCCACTGGGAGGACTCTCACTGAAGCCTGCTTGCACTGGGAGGACTCTCACTG


AAGCTCGCTTGCTGTTTTGCTTGGTGCTGACTCTGGTGATGTTAGGGAGCACTGAGATGACAGCCTATGGTTCAGGGGTGTGCAGGC


TTAGTAGCTTGGAGGCAAGCAGACTACTGTGAGTACCACACTGGCTCCTCCTCCTTAAGGCTGTGCTGTGAATCTGAGTGTCTGACT


TCTCAGACATCGTGGGGCTTGAGTCTGGCTTTCAGGGCCTCACGAGGCAGAAGCGGGAGAGTGTTCTGAGCTTGAAGGGACAGTGGG


TGGGGTGGGTTGGGTGGGGTTGGTGGGCTCCAAATCAGAGAGTGCCAGGTGTTCTTCGGGAGGAAAAAAAAAGGAAGCAGTTTTCTC


AGGGAGAGATAAAGAACAGACTTGAACGGGACAGGAGGTCCCCATTCACTGGGTCTTTGCATACCAGGCAGAGGGCTTTGCACGCTT


GTTAGAAGGCAGGGGAAACATGGCAGTGGTGTGATTAAGCTTTGGCACAGAGAAGAGTAGTAGGAAGAAGCTGGCAGCATGAAGTGA


GGGCTTGAACCAAGCTAGGGACAGTGGAAAGGAAAAGGTGGGAACCCACAAGAGAGCAATGTGGGGCATCCTCCTTTCGGCCTGGGA


TGACGTATGCTGTCTGTGAGGGTAGATACAAGAACTGTGGCTTAAGTGCCTCTCTACATTGATCAAAATCCAGCCCTTCCTTGGAGG


GTAGACAGCAGTGAGCAGCCAGGCAGCCTGCTGTCCCAGAGAGTAGGGTGGCGGAGTGCCCATACCAGCCGGCACCAACTGGCACCG


ACACCCTGGCTGGGGGCTTCTCCTTCTGGAACCCATCAGCCCTGGCCTCCAGCCAGACCTGATGGAGACGGATACACCCTCTTCCTG


CATGTTTTCAAAGATATGAGTGGGGTAGTGACAGCATGCAGAGCTAGCCCCTCTAGGCTTCATGTAGTAGCCTGACTATTTTGTGAC


TATGCGTAAGGAGCAGGTGGGCAACTATCGGGGCACTTTGGGCCTCAGTTTCTGGGAGTTTTCTGAGTGCACTGGTGCTCAATCCAT


GCAGTGATTGTAAGAGAGGATTCAAGAACACAGCCGGGAGGTTCTTGGCTCAGCCACAGTCACTATCTTTAATTGACAGGAAGTGGT


GATGGACTGGACAGGATGTATAGGAGAGATGAGCTATGGTTACCACTGAAGGAGATAAGTTGGACAAAGTGGGGTTGGCAGTTCTCC


TAGGCCATAGCTCTGATGGGCTCGGGTGGGGGGGCGGGGGGGATTGCAGGAGGCTACCCAGTGGCAGCCTGGGGTCGTCCCACCTCG


TGATTCACAGATGTTTTTTTTTTTTTCAAAGATTTATTTATTATTGTATCTAAGTACATTGTAGCTGTCTTCAGATGCACCAAAAGA


GGGTGTCAGATCTCATTACGGATGGTTGTGAGCCACCATGTGGTTGCTGGGATTTGAACTCAACACCTTCGNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNCTCCAGCCCCAGATGGTTTTTATTATCTACCTTAGGACCACCTTTTCAACACCACCAGCATCCCTACGAGCCAC


CTCAGTGCAGTGACCAGAGAGGTCAGTGTGTTCAGCCGATCAGCTTAGCCTCTGGTCTTGTCTGTGTTCCTGGAGACTTTCCTGGGC


TCACAGTGCCTCCCTCCATCGCGATGCCCCTCAGAGGCTAGCTGGATCTCTTTCCAGCGTTTCAGTTAGGGCCTGGCTTAGTTCAGG


CTCCAGAGAAGGAGTACTGCCTGGACTGGCATGTTTGTACTGATGTTTGCTGTCCTCTGTCCACTCTGTGTGTGAGCTGGACAGACA


TGAAGGCTCCCCAGGGGCAGCGTCCTGCATAGCACAGGATCGTGATGCGGCTATCTGGAGTCCTCAGGAAGACTCCAGGAGATCAAT


GATGTGCTGACACCAGCACACAGAGAGAGGTTGCTTGCAGGTGTAAGGGAACAAGGCTGAGGTGGGCACAGAATGGCAGAGGTGGGT


GAGTGTGAGACAGGCCTAAGGGGAGGCCCACAGCAGAGAATCTGTGATAAGAGGCTGGGCAGACCTGGGTCAGCCATGTGAGAGCAG


AAAGAGTGTTCTCCAGGGTCTTCACTAGCTGCCTGAGCGTGCAGGTGGAGGTGACGGCTGTGGGTGTGTGGGGGGGGGGGAGAGGCT


GGGCTTGGGGATGCTCCAGTGTTTTCATCACAGCAAGTGACAAGGTGTGGTTGTGTCAACAGCCTCAGTGACTGGCAGACTAATCAG


CATCCATTCTTCCTTCCGTGGGTACAGCAGTCCCCAAGGGCAGTCCCCAATGCCTGGATTACCTCCAACAGTGGCAGAAGAAGCAGA


GCTCTATCTCCTGCTGTACCCCTGTCCCATGTGACTTATGGCTGTCTGCTTCTCCTAGAATTTGATCTAACCTTGAGGAAACTAGCC


CAGGATCTATACGAATGCAAACACCAAGACTACTCTTGAGTCGTGGTCCAGGAGGCCCAGATGAACCCTCCCAGGACTGCTTAGATT


TGGGAGCCAGGCGACCAAGAAAGGGCAGAAGGCCTCTGTGAAGTAAAGGCAGAGGAATAGGTGGGCAAAGGAGGAAGAGCAGACTGC


AGCCAGGGGCTCAAGCAGGGGAGGCACTGGCTGGGCCCTGGGTTTAGGCAGAGGGGAGCATGTCTTATCTATCTCATCGGGCCTGGC


TAAAAGCCAGTGCTGATGAATTCCAGAAGACTTTCTAGACAGTGAGTTCTGGAGCTAGATCTGGACAGCTTTGTCTTCCAACTGGGA


AGCAAAGGAGCCAAGACTTTCCTCTGGGCTTGAGGATTGTAGAGCACCAGGGAAAGGCAAGGTTTACGTTTTCCTGCCCTAAATAAC


AAGGGTGTCCCTGAGGGTCACTGTGAGCACTTTAGGGGATTGTCCTGCAGTTATTCAAACAAGGTTGCTTGGAGGGGTGTGTGTGTG


TGTGTGTGTGTGTGTGTGTGCGTGCGCGCTGGGGGCAGAGTTTGGCTCCCTTTCTGGATGAACCCTTTGGAGGGCCTTGTTCCAGAA


TACCTAGGCCAGAATCATTTTGGAAATGTCTCTGTTGCAACTGAATGTGGACACTGGTTAAAGAGGCTCGTGGTCCTGTGTAGTAGG


GCTCCTGCAGTAACAGCAGAGACTTCCTTGGTCCATGTGATCCCTTCCAAAGGCAGGTGAGTCCCATTCCTTCAGAACCCATTTGGA


ACTGGTCAGCAAACTAAGAGGTGTTGTATGGGACTCCTGAGGCTGAGCAACCAGGTTGGGCATAGCCTACAAGCTCTCCTCAGAAAT


GTATGGCCTTTGGCACCGCATTGGCTGGGTACTGAAGAGTTGACAGGATGTAGAGTAGGCACAGCAAAGAGGTTTTATCTGGGTGTT


AATTCTGAATGGTTGGTACCAGTTGCCAGAAGAGCTGTGATGAGAAGGATGGTGAGCTGCTATCTGAGCTCAGTGAGAAAAGTGCTG


TGATTGATTGATGATGTCTATCATGGCAAGGAGAGATGGAGGGAAGAGGGGATTTGCTTTCACTGGTATGGCAGAAGGAATGCAGAG


ATCCTAGATTGACCATTAGCGAATAACTCATATGTCTTTGCATCCCAGTTTCCTTAGCCTTAAAGTAGGAGTGATAAGGTTATCGGG


TATTGAGTAAGATAACGGAATTAGACATTTTATTCAAGCGAAGACACAGAATGCGGGTGTCATTGTTTTGGACTCACTCAGGAGCCC


AAAGTGACTTCATAGCTGTAGTGAAGGCTTTCTTTCTGCTTGCTGGAGGAACCACAGAACAATGTGTAAGACAGTTGATTGGCATGA


CCTTTGACCAGGCCTGTGCCAGGCATCTGGGACCATGATACGTTCTTGACTAAAGTGTCAAAGAAGTGTTTGCTTATTTTTCTGGTT


GGTAGTCACGTAATTTCTGTCAACGATTCCCCAAATGAAGATTTAAACACTGTTTCTGTGTGTAATGAGAGAAGGCCAGATAGCTCT


CTCTAGAACTTTGTCTCTGATTCTCCATTAAAGGTAGCAAAATTGCTTTATAAAGTCTGAAAGCCTGACAGGATCATGTATTAACAA


TGCATACATTATGCAAATGTGGGTGTAGTTACTTAATTTGCATAATAGATGGGCTGAAGGAGGGCTGTAAAGGGGAAAGGGAAGGAG


TGAGGGTACTTGTCCAGATCTGTGTATATTAGGGTTCCCCAGTCACCCCACAGGGTGCGTTTCCCCCTTCCCATGCTCCTACTCAGC


CTTGAGGTTACTCTGTGTCTTTCCCTGCTGGCTAGCTGCCTGTGCTTCTGTGTCCATCCTTCACCCAGGCAGGCGCAGGGGCCCTCA


CCCTTGCTCCTTGAGCAGTGAGGCTTCATTAACTCTCACAGTCCCTCTGGGGACAGACAGCTTTCCCCAAGAGCTTCCTCGGGTCAT


TGCGTGTCCTATATCTGTCCTGCTGAGGCGCTGGACTTTGTTAAGTGACATCTTGAATTGTATGTGAGTCTTGTCATTGGGTAACTT


TTTCTTGGGCTCTGTGAAGCAGAGGAGGGGAGGTATTTTAGGGGAGCGTACCTCCTGATCCATCTACATTCTCCCTGGACATATCTG


ACAGCTGCTTTGAAAGGTTTTTGTGCTCTGGCTATAAGGGGTTTCAAAGTTCTGTTTCTCCACCCTACTTCCCGAAACCCCTTTTAG


CCCTCCTCTGTCCTATACTCCCAGGGGCTGGGACTCAAACCCAGGGTCTTCTGCATGCTAGGCAAACTGAGCCCCAACACTAACACC


CACCCTTCCCCTGAGTTTGACAAGAACTGAAACTGAGACCAAGGGTATTTGAGGTCAGAAACCCAATGGATACTCCCTGGAAGCCTA


GATTTGGAGGGTTCAGGTTTAAGGGGTGCTGGGAACCATCTGTGTAGGTCAGACAGATGTGGCAAGCAGCTGGCTAGCTGGCTTCTC


TGGATGGTACAGTGGGTGTTCTGTGCAGTTGATAGACACAAGAGCCCTGCCCCCCTCTGGCAGAGGGTGGACAGGGGGCTAAGTCTG


CAAACAGTCTAGAGCTTGGTGTGGTCATACCTGCTCAAAGTTCCCAGTATTAGGGCCCATCCAAGGCTCTGAGACCCTGAAGATAAA


CAAGAACTTCCAGCTTTCCTTGGCTGAATTCCTACTGAGAGTCCTGGTATTTCATAAAGTCACTGGGTTTATTGTCCCCATTTCATA


GCAGAGTATGATAAGGCTTGGTCTCATAGCCAGGGAGCACCCAGGAGATCTTGTGGAGATCTAAGGGAGATCTTGTGACCCTCCCCC


TCCACGGCCTCTTCTCTTGAGACTGGAGTTTGACCTGGACCTCTGGTGCTGGGGGTGTGAACAGAGGGTCCAGGCAGTGTGATAGAA


GTAAGGAAAGGGACTAGAACTGGAGTCACAAGAGTCAGGAATATGAAGGACAGTAGAGAAGGCCCTGAATGAGGCATGTCAGGGAGT


CTGAGTTGACCTGGTCTTTGGCGGCAGTTCCTGGGTGGGGGTGATGTGGGCTGGCACCAGAGGGTGAGGGAAGGTGGGTAGGGACAC


TGAGCAGGGTAATTCCAGAGATTGACAGACCCTTTCTGCCCAGATATTGGGGTGCTGCCAGGAGAGGTAGACCTGGTATATTGGCTC


CTGTCCTGTTCACAGGGCCGTGGCTGGGGCAGGTGCAAAGTGTGGCTTCTCCCATTGGCCTGTTTGTTCAGCTGGTGCACTGGCATC


TCCTGCCTGGGGTTGGGGGCATCCGAACAGTTTGTGGACCCTTTCTGTCTGGAATGAGGTTACAGCTCTTTCCATACCCTCACACCC


GACGACGGACCCCAGAAGCACAGTGGAAGATGGCGCCAGACAGAGTCTCATAGACAAGGCCCAAGGGGAATCTGAGGCCGAGAGGGG


AAAGTGACTGTCTTTATCTTCGGTAGCCAATGGAGTGATAATCATAGGGGTTCTGGCTCACAGGTCACAGGAGCCTCTCCTCACTTG


CTCCACTTTGGGTTTGCAACATTGCCTCCTGGGAACATGAATGCTCTTGTATATATATAATATATAATATATAATATATAATATATA


ATATATAATATATAATATATAATATATAATATATAATATATAATATATAATATATAATATATAATATATAATATATAATATATAATA


TATAATATATAATATATAATATATAATATATAATATATAATATATAATATATAATATATAATATATAATATATAATATATAATATAT


AATATATAATATATAATATATAATATATAATATATAATATATAATATATAATAATAATATATAATATATAATATATAATATATAATA


TATAATATATAATATATAATATATAATAAATAATATATAATATATAATATATAATATATAATATATAATATATAATATATAATATAT


AATATATAATATATAATATATAATATATAATATATAAATGTGTATATATATAATATAATGTGTATATATATAATATATATATTATAT


ATATATTATATATATAAACACCTCTTCATCCTCTTGGGTTAGGCGGGACTTTGTTCTGGAGTGCTCTCACACGGTATCGCCAGCGGA


TGGAGCAGAGTCTACTGATCCTACATCTGTCAGGTGGGGCTGTGCACACTCACACAGTTTGTTCTCCCAGCCCTGCACGGACCCTTG


TGCTCCCTCTCGGTGCCCAGGCTTCTGACCCTGGAGGGGCTCTGGTTAATGTCGGCGGTGGGCAGTAGGGAGGAGCACCTGGCATGC


AGATCTGAGAGGCTGGCTGAAAGTGATGGCTGTTTATAGACTGTGGGACTTTAGGTGGGCAAATTCGCCTGTTAATTTTCTCATGAA


TGAAATAGGGGATAGTAACACATTCTTTGGGGGGTACACCAGCCCTGCTACATTTTTTCTGAGACAGGGTCTTTACAGCCTTGGGTG


GCTTCAAACTCTATGTAGACCAGGCTGGCCTTGAACTCACAGAGATCCTCCTGCCTCTGCCTGCCAAGTACTGGGGTTAAAGTTGTT


TGCTATCTTGTCCAACCCCTGTTATATTTTGGAATTACCTTGGGATCTTTTTTTTTAAACTGATGTAAAGAAAAGAAACGACAACAA


CAGCACCCCACGCCTGTCCTGTCCCAGCTACCTACCTTCTGACCTCATTGGTCAGGACTACAAGCCTGGGTACCAGGGAATTTCCCA


AGCTCCATGGGTTATTCTAATGTGCTGCAAAGTTTGGGAACCACTCTGTGGGTTTTGGGGGATTAAAGAAGATGATGCAGGTTCCTG


GGGAGAACTCAATAAATGGTGGTAATTAGGATTTTCCTCATTGCATTTAATGTGGGCTCTGATAGGAGAGGGGGGAACGGAGGGAGG


GTTTCGACTTTATTCCACTAAGAGTTTGTCCTCAGTGGCTAGGCTTTCCCTAGAAGACTTGTTCCCTCATTTCTAACACTATTTCTG


TCACTTTAGAGCCAGTTTTAGCCTTCCTCATAGCCATCATGGTTATGATTAGGTTGGGTGCCCAGACGGGAGCTGGGGTGTGCTGGA


CCCAAAGATAAGATGTCAGGTCTCTCCTGAGTCTCCTCCTGGTGCTTTTGAGTCCCCAGGATGGCTAATGGAATCAGAAGCTCAGGA


TGCTTGCTGTATCTTTGAAATGCTCTCCGCTGTTGCCTGGCACCAGCTGAGGCTGTGAAGGAAGACACATTTCCCCAGACTCCTCTG


CTGTCCTGACAGGAAGTTGTGCATCAATGGGCTGACAGGAAGAAAATGGCTCTGCTGCTGGGAGGATCTCATGGGGGCTGAGGGAAA


ACGTGGAATCTTCTGGTCCACACAACAAGGCCCCTCTTTCCTCAGGCAATTTCCCCGTTTATTTTCCTCGCAGTGACAAAGATTGGG


TTTAGCTAATGAGGAGCCGTGAGGGGAGAGTGAGGGGGGGGGGGCGAACCTGTGCAGGTGCGCCAGGTGGGAAGCGCTGTGGCAAGC


TGCCCTCGCTTCAGTCAGTGCCATTTCTCCCAGCCCCCTGCCTGCGGGGACTGCACGATGACTAAGCATTCTATGATCTCAAATGCT


TTTTCCTCTGTCTACCAACCACACCTTTGCAGACGCCTTTGATTTCTACTTCTTTTTACCAGCCCCCAAACCCCACAGTGAATCTTT


TAATAGCATAGGCCTTTTGGATCTCTAACCAATCAGTTGCCAAATCCTATCCAAAGTACACCCAGAATAGATTCTTTTAATAAAATA


GATCACATTTAAGCCAGCATAAACCTGTGAAATTTGTACATTTCTTCTGGAGCACCTCTTCAAATTTTACAATATTGAAATCACCAC


CCAGTGACCTTTCAGGAAATACTAGATAAATTGCAAGTGGCAAATAGACAAACTAAATGGACTAAGCACCGTTTCTAGCAAGTGCCT


TTCCTGGTGGGCTCTTAGTCCCAGTCTTTGAAATCCCTGACCCCCAATCCCCTACCCCATCCAAGCCCAGAGATCTACCCTGTTCTA


CCTTGCAGGCCTGCTTGCTGCTTTGCTCCTGGCAAAGAGCTGATGGAGTGGTGCAGCTCTGAGAAACAGTACTGGTATGTGGCTCAC


GTGGCTCGCAGTATGTGGCTCCGCAGCACCTTGTCCAGTCTGTGTTTGTCTCTGTGCTCTATCATTCAAACCCACTTCCACCCATGG


TCAAAGCCCCCAGGGTGCTCTGGTGGGTGGCTGAGATCTGCTTTCCTAGGCAATGGGAGGGGGTCCTTGGCTTTGCCAAACATGAGC


TGGGCTGTGGTTTGAGCTGGGTGATCTTCTTGATGTGGAGACACTCCGTGCCTAGGCTTGGTTACCTGAGTGTGATGGCACACTCTG


TGTAAGCTGTCATTTGTACATGATGCTGTCATTTGTATCCCCGGGTCTAGCCTCGGCTATGATTCTGCTGCATGGGTATCATCTTGC


TTGCCAGCTGTTGGTGGACAGGGTGTGTGGTGCAGGAATAGCATCCTGTTTGTGTTTAATGTAGGGAAAGCCATTTTGGAAGGCAAT


GATCTATAAAACCATCACCTCAGTGGAAACCCTTAGAGGGTCCTGGTCATTCAGTGTGCCTGTGAGTCAATGTGTCTCTTGGGCAGG


GGCAGGCGCCATTGTGCTCTGCTTCCTAAAGGCTGTTAATTGCAGTTGACTCTATGGTCATGGTCATGCGTTTATGGGCTCATTTCA


TGGATAAGCAAGCTCAGTCACTAGCCTGACTTCTTGGCCATCACCACTTGATGACCCGTGTCAGCACCAGTAGGAGCTGATCTTCCG


GCCACTTGGATTTCCACCACTATTTCCCTGTGACTCCTCACACAGTTCAGTTGTACCTGAAACCCCACTTGTCTCCCATGTAGGGAG


GGCAGAGAGAAAATTACAGCATGTCCACAGCAGTCTGGCCTTTCTGTAGATGAAGCAGCATCCTGAAGGCAAAGAAGTCTGGGTTCA


CTTCCTTCTTATTTTCCCCCCTCATATCTCAGGCAAAATGCTGGGTTTCTGGAGGAAGTAGAGAGACCCGAAGATAACACACTGTGT


GTGTGTGTGTGTGTGTGTGTGTAAGTGTGTGATGTATGTTGGGGGTTTCTGATTGTCAGATCCCATGATGTGAGTGTGAGCTCTGGG


GCTGTAGACGTAGGCAGGGCTTGCACCCTGCAGTACCTATCCCTGTCCCAGACTCTGGGGAAGTGGCCAAAGTCTCAAGAATGTGTG


TGTGTGTGTGTGTGTGTGTGTGTATGTGTGGTGTGCAGCTTGTATCATGCAATGTGCAAAGAACTTGCATGGTGCAACAGAAGGAGC


CCCGCGGTGCAGATCTAAGATCTAGCCACTAGGTCCTGTTTCTAGATCTGGATTCTGCAGCGAGATGACTGTGACCCAGGCCTCAGT


GTCCCGGCATGTGAGGAGTCCGAGGCCTGGCCCTGCCCTAGGATTCCCGGCCTCTCCCTCTTTGGTGGCATCTCTTTGTTTTGTATT


TGTCTCCACCCCTTGCCATCTGACTCTGTCTCCTGGCTTTACCATAACCAGCAGCTGGCAGTGGCTGGAGCCAGAGGGATGGCTCCT


CTAGGAGGAATGTACTCTCCTGACTCTGCGGACCATTGGCTTCCTCCCTCTGACCCCAGCACACTGGGCTCCCACCTTCCCAGCCTG


GGCCCAGCTGGGTTGCTTCAGTGAAGTAACCACTTCTCCTGCTTACAACACTCCACCTGGTCTGAAAGTGACAAGAGACAGCTGCTT


GGTAGTCAGTGACGTCTTTGTGGAGAAATGACAGTGCATTTGGCCTGCACTGTCTTTTTCCTTTGCTGCCTTGGGTTTTAAAACTCA


GCTGTTGTTATCTACACTGGTTGTCTGGGAACTCCAGGGTCGGCTCTTCCTGCCCAGGGAATAACTTTTGAAAGGCTCATTGGCCCC


GTGCTCCCTATCCCATCTAAGTGTCCCTCCGGGGCAAGGAGCCTCGGGAGGGCTTGGCAAGGCTCTCTGTTTTCCTTGGTCTTTGAT


CACAGCTGTTAGAGTTAAAAGCTTAAATAATGCATGTTAAACAAATAAGTATCTGTTTAATCAGTGCGATGGGGAAATTAAGGTGAC


TCAGGCTTTAAATTCCTAAGTGTCACTACCTGAAAGATGGCCTAAGTGGTAGAGTAATGGTCTACTCCTCTCTCCTTGGGAATTCAT


TCATTCTCCATCTAGCATTTATTGTGCATGTGCTAAGTCTTATGTAAGGCAAGGGGACAGAAGGACAGATGAGTCCCCCTCCCTCTT


ACCTCTGGTGGCCAGAGGAGAAGACCAGGGCCTGTGGGCCTTCCGGGCTCTAGCAGGCTCCTCTGGACTTCACTCTTTAGTTGGCAA


GCTTAAAGCTTGTTCCTGGAAAACAGAAATAGTGCAAAAGGGAAGAAGTGTGGGTGAGGAGCATGAGTCGAAACTGGAGGAGAGAGA


TGGGAGAATCTAGCAAACTTTCCCGTGAGGGAATGCTCCTCGCAGCGCCACAGTTCCCTGTTGAGACCCTGGCCTTGGGCAGCAGGA


GGCTGAGGAAGGACAGGTCCCTGTTCATTCTCTGCGCTGCATGGCCTGAGTTTTATCATGCTTATTTTTCCAAGACAAGGTTTGTCT


AAGTAGCTCTGGCTGTCCTGGGGCTCACTATGTAGATGAGCCTTGAGCTCAAGGTGAGGCACCTACCTGCCTGTCTTCCTAGTGCTG


GGATTAAAGATGTGAGCCACCATACTTGGCTAGTTTCATCATCTGTAAAGGCAGGTTTTGATGAGATGCTACAAAGGCCTGCTTAGA


TCTACACTTAGAGAGAGGCGTGGGGCTGGTGGACCAAATAGAAGCCACTCAACTATAAAATGATTTTCCTTGGCTTTTCCCATTTTG


ACACTAGGAGACAGCTTGTGGGGCCAACGAGCACCCCATTACCTCCTCCAGTCGCACTGCTGGAAGTTGGAAAGTTCTGGGTCTCTG


TGTTTGCATATTTTTCCGATTTGGACATGCTCTTCTTAGAGTTTTAGGAATTGTTTTCTTTCTGTCAGTGAGGCCCCTTGAAGCTTT


CAGGGCAAAAGGCTCTTGAGTTGGGCACACATTCCCTGATGCATTTGCCTAGCTTTTTGTCAGGCCTGACACCAGGTGCCCGTGGTC


ATCCCAAGTACCCAACCATGGGGCTACTTCAAAGCATAGAGAGAGCCCCCAGTACAGCTCATGCTTATGGGTCTATGGGGGAAGACT


TGACAATGTTTTGGCAACATTGTGTTGGAAGAACTGGACTTCTCACCTTGTGGCTCTAATTGCTTAAATATGCTGGGCCTCAGCTTT


TCTGTCCATGAGATGGGAGCAACTTGCTCTATCTCCTAAGGATAAAATAGGAAATTGAGAACAATAAAACCAAACAAAACCCATAAA


TAGGAAAATTCTAAGTCGATGTCTAGGACTCACTGATTTGATATCAAATATATTCTGATAGTTAGCCTTTGACAGGTTACTATCTCT


CTCTGTTCTGAGAAACTCAAGCCAGCAAGGGTTAAAGCAAGCTAGGCTTATGACTATGACTGTCCATAATTGATGTGATAAACCTTA


AAGGAGTGACATATAAGTGCAATTAATCCAGGCACAGTGACACTGCCTTGCTAAAAATAGTGTCTACTAATAATTACTTTGATCTAG


CAAATGATGCCTGTCTGCTAGGCTGGCTGGGGCAGGACGGGTGGAGGGTCTGCCAGTGCAGTAGAAAACTCTACTCCTCTCTTCTGC


AAGGCGAGAGGCTTCAGGGTGGAGACGCAGGGAAGGGGAGCCCATCTCTCAGGCCCTCTGGCAGCAAACAGTGTGGACGAGAAGGTA


TCTGACACACCATTTAGTATCATACACTGTTACTATTCATATTAATAATTATGCCAGACACAAACTTGACTTTCTGGGTTAGCAGGG


AGTATGGACGACCTGTGTATGGGCTGTACTGTGAGCTCATGGGATGTCTGGTCTTTTTCAATCCTGGAAGGAAGAAGAGATTTGCCG


TCACTTAATTGATATTAAAGATGGTAACAGTGCCAAATGGTCCACCTGCAATTTTTGGACTGGCTCCCTAGGTGGCTGGCCTCATGA


AGGTAGAGGCAGCTGGCTGGGATCACGGCGCTCTGTGGCCATGGAAACAGATGGAGCACAGAGGGAGGGATCAGTCAACCTGGCTTC


TGTGGAAGGGGAGCAGGTGTTAGCAAGAGCAGAGTGGCCTTAGCAGGGCTCTGTCTGGGCTCCTACAATCTTGGACATGGAATTAGA


AAGCTTGAGGTTAGTTGGGCCTCTGATCTGACACTCAGGATAGGCAGACCCTGTGTGTCTGGGGCCAGGCTACACAGTGAGTTACAG


GCCAGCCAGGGTTACCTAGAGAGATCCTGGGAGAAGAGGGTTAGGAGAGAGGGGAGTGGGGAGGAAGGCGGGGTGAGGGGGTGGGTG


GAGAGAGCTTGAGGTTAGAGCCTAGCTCCTTCACCACCCGAGTAGCCTTGGGAAAGCTTATGAACAAGCTCTCTACACTTGTTTTCT


CCATTTTCAAGTGGCAACACAAATTCCATTAAAAAAGAAAAAGAAAGAAAGAAACAGCCGGGCGGTGGTGGCACACGCCTTTAATCC


CAGCACTTGGGAGGCAGAGGCAGGTGGATTTCTGAGTTCAAGGCCAGCCTGGTCTCTATAGAGTGAGTTCCAGGACAGCCAGGACTA


CACAGAGAAACCCTGTCTCAAAAAACAAAACAAAACAAAAAATAAAATAAATAAAAAGACAACCAGCTCCTCTGGGTGGTGGTGGCG


CACACCTTTAATCTCAACACCCAGGAGGCAGAGGCAGATGTATCTCTGTGAGTTTGAGGCCAGTCTGGTCTATAGAGTAAGTTCTAG


GACAGCCAGGGCTACATAGAGAAACCCTGTCTCCAAAAACCAAAGCCCAAACCAACCAACCAACCAACTGACCGACCAACCAAACGA


AAAAACAAAACCCCAAGAAACAAACCAGCTAGCCCCAGGATCTGCTGGGCAGCAGTTCCTCAGGAGATTCTTGAGTGTTTAAGCTTG


GAAGGTTCCCAGGAGCAACCTCCACGGGGCCCCCAAAGCTGTGGACAATCTACTGTTGCTAGACAGGGACACGCTCACATTGTGGTT


TCTTTTAGGGTCGTTTCATACCCATTTGCCGCGCCACATTTAGTGCGCATGCGCACTGATGTGTAGGCCACAGCTTCCAAAGCACAG


ACTCTTCACCCTCGTTCTATTTCTGGACCGTGGAATTGAGACAGTCTCTGTTCTTCCAGCCTAGACAGCTTTGTTGACCCTTGTTTC


ACTAGTGTACATGTCGGGACCCAGTTCCCTTCATAGCAGATTCTTGAATGTCCCAGAGCGTGTTCCTTGGATGTCTGGGGAATGCTT


CTTAAAGCCGATCATGGATGCACTCACGAATGTGGGCGATGTCTGCTTGGTTCATCACCGTGATTAAAGATCAGGAACGGCTTGTCA


CCGTTCTTTGGGAAAGCCATATTTTCAGGTCCCAGCTGGAAAAGAAGCGTGCAGGGGATTGTAGGGCGGAAATCCGCTGCCTGCAAC


TCCCTGATCTCCAAAGAGGCGGGTGACCGACCATGTGACCTGTAGCTAGCCTTCTGGGCCCTCAGATAAGCTTGCTTGATCTGGTTG


GGTGACATGGCTCCCGCAGTGCCCCATTGCCGGCAGTCATCGCAGTCAAAGCAAAAGGTAGGCAGGCTGGCAACAGTTTGGTGCCAG


AGGACTAGAGAAGGTAGCATGAGTTTATAGAGTTTATAAAGGTACCATGTTCAAGCCTATTAATAGCCCATGTTTGGCCTCCGCTGC


TCTGTCAACATCATCTATCACATTCAAACAATTGAAGAGCCCATGCCAAATGGTTAGGAGTTAACAACTCACGGCTGGGCTGAGTTT


CTGAAAACAGAATTTCCACTTCTTATGCAGACTGAAATGCCAATTGTTCCACGCCGACTGGTTATTTTTCCAGACCATTTCCCTTTA


TTTATGTTTAAGCGGTTGTGTTTTTAAGTGAAAGGAAGATGGAGAACCTGGAGTAGGTAATTGTTATTTCTCTTGATTTGCCCTTGA


ATGAGCCATCAGAGAAATAGTCCTTTTCCAACCTTGTGATGAGAACACTCAGAAGCTGGGAGGAGTCAGACAGGACCCTGCCCTTTA


GGGGGCGTGTTCAAGATAGATGCAGGAAGGACGGGGGCAGGGAGAAATGGCAGCCCAAGCTTTGGGAGAAGGGGACTCTTGTCCCTT


TCTGTTTTGAATGTGACCTTGGGTGGGAGGGAGCTCTTTTGGGGCCTCAGTCTCCTTATCTGTAAAATAGGGAAGCTGGCTTAGCGG


ATCTGAGGCCAGTGGCTGATGGCAGGTGTGTGCTCTGCAGTACTTTTAGACACTACAAGACTCACGAAATTTCTGACTGGCTGAGGA


AACTCACTGGCCACAGCAGAGGAAGGAGAAGGACCAGGAGGAATAGATTGACTGCTGGAGAAAGCAAACGACTAGGTGACAGGTCTG


GAGGTGGTTTCTCTGACAGGGATTCAGGCTTTTGCAGAGCGGTTGAATTTAAGAATGGCTGGATGGACCACCTGATGAGCCTGGCAG


CTCAAACCTGGATTTGAAGGTTGCCCTAACACAGGCTGATTTCTGCTGGGGACAAACCAGCCATCCTGTCCTCTGTGTCCTTACTTC


CAGACCTGGCATGACTGTGTCCTGAGAAGGGGAACTGTCATAGACCCCTATGAGGCAATGGTCGGAGCATCAGCTAAGCACTACACC


TAAGAAAACTGAGATCAGATTTCTGAGAAAGTTGGGGCCTTCCCAGGTGTCTCCCAAAGGCTGTCTGGAGAGGAAGTGAGCCCTCAG


TCTCTGAAACCATCAGTCAGACAAAGCCTAGATGACAACTGCAGCAACTCTCACACAGGGAGCAGGGGGGATTTGGCTGTGCGGCTT


CAATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTACTTACTTACTTACTTTATTTACATTTCAAATGTTATCCATTTTC


CTGGTTTCCCCTCCGAAAGTCCCCTATCCCATCCTCTCTACCCCTGCTCACCAACCCACCCACTCCCGCTTCCCTGTCCTGGCATTC


CCCTACACTGGGGCATTGAGCCTTCATAGGACCAAGGGCCTCTCCTCCCATTGATGTCTGACAATGCCCATCCTCTGCTACATATGT


GGCTGGAGCCATGAGTCCCACCATGTTGTCTCTTTGGTTGGTGGTTTAGTCCCTGGGAGCTCTGGGGGTTCTGGTTGGTTGAAATTG


TTGTTCTTCAACCCCTTCAGCCCCTTCCTTCCTTTCTCTAGCTCCTCCATTTGGGACCCTGTGCTCAGTCCAATGGTTGGCTTCGAG


CATCTGCCTCTGTATTTGTCAGGCTCTGGCAGAGCTTCTCAGGAGACAGCTATATCAGGCTCCTGTCTGCAAGCACTTGTCGGCATC


CACTATAGTGTCTAGGTTTGGTAACTGTATATGGGATGGATCCCCAAGTGGGGTAGTCTCTGGATGGCCTTTCCTTCAATCTCTGCT


CCACACTTTGTCTCTGTATCTCCTCCCATGGGAGATGCCACCAATGTCAAGATTCAGGAACTTCATTATTTATGGGTACGACCATGT


GTCTGGTGATATCTCCGTGATGATGTTCATTCCTTCCTCCTGGGGGTTCTTTCTTAAACCCCAAAATAGAAGCTCTCACCTCTAACC


TGTATATCATAATTGGAGAACTTTTTAAAAAGTCGGCAGAGATTCTGAGTTCATTGTTTTGGGTGGGGCCAAGGGCACTTAATCCTA


GGACCTGGGTGATTGTACCTGGTGGAGTTGCCACCCACATCCAGACTCACTGTCGGGATGAAGAGACACAGCTTAGCACGATGGAGC


TCATTTGCTTGTGTTTATCTCGTGTCCGGAAGGAGCCTTGGTGGCTCCCTTTGCAGCAGCAATCGAGCTTTAGGAAAGCCCTAACCT


GTTGTGTCTGCCTCCCACACGACACAGTGCACAACACATGGCACGCACACAATACTAGTTACAACCCCGACTGATGGTCGGCGATCT


AAGTGTGCCAGGAGTTACATGACAAGCAGCACGCTGCAGAGATTTCCTGCTTTGACAGCTCCTTTCTGCCGAGACCTTGTAAAGGAA


ATCATCTCCTTAATCAGAATTGTGTTTGCAGCCGAAGGGGCAACTCATGAGACTTGATATTTGGAGAGCTTGGTCTCCAAAGTGACC


TTCTCTTGCTTTCCTTGGGGTACCACAGTGGGAGAGTCAGGCCTGGGGAGGATCGCTGCCTCTTAATTGATGTTCTGGCCATCATGC


TGGCTCCACCAGACAATGCTTGGCCACCCTCTGCTCAGAGCTGAATGTCCTTTCTATTTTCACTACATGATGTCCCTCAGACATCAG


GTCCTATGTCCTTCTGGAAGTGACAAAGTAGAAGGCCACAGAGAAATGCCCTAGGCCAAACTGATTTTATGTACTTTAGTCCAAGAG


GCTGTCTTCCTTAACTCGCTAGCATTTCCTGTCTTTCCTCCCCCATGCCAGCCTAGGCCCGGGCTAGACTTGCAGGAACATCCCACA


CCGCGAGCCCTGACCTCAAGCTGTCATTGTTAACATGCCTCAAAAGCACACAACTGGGACCTGGCTGTGAGATTTCCCTCCAGACAC


TATGCTATGAGAGCACAAGTCTTAAGAGTCAGGCCTGACTGCCCAGGTTCAAATCTTACCCCATTCCTTCCCTGTCTAAGGACTGTG


GGTGAGAGACAAGCTTCTTCTCAGCTTCAGAACCCTCGCTGTAGTGTGGGACCACATAGCAAGCCAGTATGGGACCCATGGCAAGTG


ACCTTTTGATCACCCTTGCCCCCTGCTTCTTGAATTTGCAAATCCAGGACAGAAGTGTCTACCTGTTGGCACATCTCTAAATTTTGT


TCCCTTCTCTGAAATAGTATTCAGCATTCAGCTGATATTTATGGACCTACTAAGCACTGGACAGCATTTCACATGTGATGACATAGG


AATGAATTTATTAAGAGATGCTACCCTCTATGGCTGATACTCTGGCTGGGACAAGCAGTGGTGAGGGTAGTACTGACTGGGAAGAGA


TTCCTGTGCAGCCCCAGGGAGTGTGGGACCAGATCAGGTCCCTGGGATCATCTTAGGCAGGTAATGCTCCCAGCTGAGAAGATGAGT


GAGTCAGGAGGTAGAGAAGGTGGTTGAAGAGGGCACAGCAAGGAGGGTTCCAGGAAGCTCTCTGCCCACGATTAAGGTCAGACCCCC


CCCCCTCCTAAGCTGGAAAGCCTGCACATAATGGCCCCGCTGAGCCTAGGACTGAGAGGAGAGAGTGTTCCATTTGAGGCCTTCTGC


CAGGGCACTATGCCTCAGATGCACCCCAGGAGTGGGAAAGCTCAGAACAGATGTGCTACATATAAAGGAAGAGAGCCACATGCACGG


GCCACTGTGAGGTTGAAGCCCCTCTGTGGCCACTGGAATCTTAGACAAATGGTCTCAGGAAAGGTGTCTGAGGCTTAGAGCCTAATC


AGGCTGACCCACACCCTCAGAGGTTACACCCTGGAGGAAGGGAATGCCCTCTAAAATCTCATTGCCTATGGATAAGGCTGCGGGCTG


CAGCTCATTCACGCCCAAGATGGAGGCGAGGGCTGTTCAGACACCTGCTAGTGCCACCTCTCCTGATTCTAGTCACTCCCTGATGAC


TAAGGCCCAAAGGAACCAGGTCTTCTCTCAATTGGAGCTTCCTGCCCTCCAGACCCCCCCTGCTAGTTGCCTCTGTCTCTTCTGACA


TTTGGCTGTGGGCGGGACGAGTGTGGAACACGATGGAACAGGGCTCAGCTGGTGGGCAGGATTCAGTCTCAGTATACTGTGACAACA


GTGTTCTGAGGCTCAAGGCAGGGCTCAGCCCAGAGTTTGGGCGAAGCAAATGCTCAGTAGTCTGTCTGGTTGAGTGAAGGAGCGTGT


ATGTGGCCTAGTGACAACCCAAGGCATCTCTGAAGTACCAAGGACAGGGGTGCTGATAGTGGAGCTTGTCACTGGGACCGATTCGTT


TTTCTCTGCTCTGGGTGGCAAGAGGAAGTGCATTTGACTTAAAAAATATTGTGGAAAGATAACCTTTTCTTTTTTCACTTGTATCTC


GTGTATGTGAAGGAGAGCAGAGGAACTGGAGACCCTGAGAGGTTAAGGCCCAAGGAAGGAGCTGGAAGCCCAGTGTCTCAAAGGCTT


GACTTGAACCCTAGTCTTTTGTTGTCAAGTTCTATGTTATAGAAAGACACAATAAAAACCTTCTCATTAGCTCCCACACTAACAACA


GAAACCACTCTTTGCTCTGTTGAGAAGACAGAATGAATGGGATCTGGAGCTGGCCGTTTCAGACCCACAACTTAATTCCTTACAAAA


GAAATGTTTACAAAAGGAGTGTTCCTATGACCCGTATGTGTCCTGGCCTATAGACTGATGATATAGGCCATCGAGCACACATAGCTA


AATGTCAGGGTTTTGAATTCCAGAACCTTCTTTCCTTGGAGGTCTGAGGTATGCACAAGGCCAGGCATTTAACTTGCTGTAGCAGTG


ACTACTGGTCACTCTACAGCGAGTCTAGAGCTGACTTCCAAGCCCTCTTCCTGATGAAGTCCCCAGGGTCTTAGGTTCTGTTTCTCA


GATCTGTGCAATGCCCAGCGACCATCCCTACCCACTGTGATGGTGGCATCAGATTCCCCTGCTCTCAGGAGGGCAGGATCGAGTGGG


CTGAGCCTTCCCATGATTCCATTCTGGACCATGAATACCTACAATGGGAGGGGACATCATGCCAAGGATGCTGGTAGGCCCAGCATG


ACCTCAGGTGATTTCATGACCCTGACGACCTCAGGCAGCTACACCCAGGAGGAAGACCAGCTAAGGTCTGATCGGGCAAGGTAGTGA


AAGTTCAGAAGGCAAAGTCAGGAGAAACGTGCAGATGGGAGCCAGGGAAAAGGAAGGCTAGGCTAGGTGCAGAACCAAAGCCCAGGT


AGGGAAGAGAAGCCGGGTGTCCCTGGAGATCAGCAGCCAGGAACGCTGACTTCCCTGCCAGGGGACTGGGGGTGGGGAATCAGGGAA


GGAAGGCCTGGCTTAATCTGCATAGCATTAATTAGCAAGAGTGTCTAATTAGGACAACCATTACAGAGCTACAGTACGAAGCCAGTG


CTGAATATCAATCAGTCTTGGAGCGGTTCCATGAAATTGAAGCAAAGGTTGACCTTATTAAACAGAAAAGATTTCTAACTCAATTAT


TTCCCCAAGTCGAATGCACCAACCGAGGTGAAGTCAGGAAGGCGCATCAGACCTTAACTCGGGAAATACAGGTTCTGGATGCTATCA


CCTTTCTCCCTTGAGGGCTTCTAACGAGTGACAGGAGTCATGAATGGGCCATGTGCGTGCACTGCGTGCTCACATGCACAGCCCTGG


AGCTCATTACCTTGGCTGGGGGAGGAGCCTGCGCATCCTTGTGCTGGGGAAGCTTATGTTGACTTTGGCTGGTGCCCTTACCTGACT


CCGTGCATCATCTTCTGCCTGCCCCCCCTTCTCAATGTTCCAAACAATAAAACACATTAAAAACTTCAAAGTCTCTGGGAAGATCTA


CTGTAATCATTACAATTCTGGCCTGTCTCTGGAAGCTACCAGGCAGGCCAGGAGAGCAATTTATACCGCTGGCTCAGAGGCCTGGGA


ACCACTCCATCACCCTGTGCACAGCCCCAGAAAGGGACCCAGCAGCCGTGAGCAGCTTCTCTTTGAATCTGGAGGCCAGTGGGCTCA


GCCTCAGGGCAGCAGGCTCACAGCTTGAGAGAGGTATAGGTGGCAACATGGCTCCCTCAAACCTCCTGACTTTGCCATTTTTTTTTT


TTTTTTGGCTATGCCCTTTGACAAGTTAGGCTTCTTGGAGCCTCAGTTTCTCTGTCCCCGAAAGAGAGTCCATGATGCCTCCCTTGC


ATGGTAGGTGCCTGTAGCAGCAGCAGCAGCAGCAGCAGCAGCAATGCTTTGTTCTAGATTACTATCAGTGGGTAATCACAGACCCGA


GAAGGGCTGCCTCAGGAGCAGGACAGGGACCACACTGTAGGAACATCTCCAGGAATGTGTCTTGGTCTCCTACCCAGCCATTCGTCT


CTTGTGCAGCCCAAGGCTCCACTGAGGTAACAAGATACACAGTACCTGGGACACTGAAGGGCAGGGTAAGTAAAATCTGGCAAACTA


AAATCCGAGTTCGTCGCATGACCTTGGAGAAGTCACTTTAACAACTCTCCAACTAGTATCGTTTTATCAGTAAAATGGAAACATTAG


GTTCTACCAGAGGTGAGATAAAATGCGTGCTAGGTGTGTGGCTCGAGGTAGCACATGATCAGAGTTCAAAGAAGATTAGCTATAAAG


TGCTTACTAAGCGCCTCTTAGATTCAGGGCATCAAATAGGTGAGGGGACCATATAGTATAAGTGTGTTATGTTCTGGTCCTCTGCAA


AAACAGGTTGCACTCTTAACGGCTGGATCACCTCTCTGGTACTCTATCGGGAGTCGTTTTTATATTTGTCTAGTCCTGTGAATCCAT


GGAGCAATAAGACTGGTCTGAAGCGGGTGCGAGTCCCTAAGCCCAGCCCAGGGACTCAGAGGCCGAAGCTCCCAGCTGGTGTCAGTT


CGAATTTCCCTGCTCAGGCTGAGAATAGTTACAATTCCAGCCTGACACTAGGAAACGGGCGTGAGTAAGTGAAACGGAGTCTCAAAG


CCCAGAGAAGCTTCGGTCGTTCATCCCCATTGCAGGGATGGACCTGAGGCTTGCATGGGCTCCTGCTGTCACCCGTGGGTGGTAGAG


TGCATGTGACACGAAAAGCTCGATCTCTCCACTGCACAAAAGCCTCTTACTGGCAGCGCAGGGCTCAGATTTTGAAAAATAAACTTG


TCAATAACAAAATGCTATGTCCTTATTAATAATTTGAGGAGAGAAGGAACATGGTAAGAAAATGCCCTACAATGCTGAATATTGATA


TTTTCCACAATCTTTTTCTACATGGGAAATTTCAAAAACAATCAGAACCAGAACGGTTTGGAGTTCAAAGCTTTCCAGTTAATATTC


CGTCACAATTTCTCTCCATGTCTTCAGATACTCTCTGTCTTTAGGGATGTACTAGTGTCCATCATTGGGTGTCCTTAGATGGTCTGA


GCCGCTTGCACATCCATGACCCTGTAGGACTAGACGGATATAAAAACGACTCCCGATAGAGTGCCACAGAGGTGGCCCAGCCGTTAA


GAGTGCAACCTGTTTTTGCAGAGGACCAGAATGTGGCTCCCAGCACCCACATTGGGAGATTTACAACTGCCTGTAACTCTAGCCGGG


GATCTGACTCCCTCTTCCAGACTCCGTGGGTGCTGCACTCACATGCACCCCTCTTACATTCAGATTCTAAGACTAAAAGTAAAATCT


TCACATATAAAAATGCCCCTGTGTATTCTTCGTGCTGGGGATTATTTCTTTGTTTTTAAAAATGCAAGGGAAAAGGGTTGATCAGTT


GGTCATGGGACTCCTCCCAAGCCATCGAGTCAATTTTAAGGCCCCAGATGGAGCAGGTTGGGGCGCAGCAGGTATGGCAGGTGCCCC


ACCATGTGGTGTTTGGTGACTAATTAGTCAGCCTGTGTCATTGGTGTCACCCGGAGAGTCATGTCAGTGGAGTTCAGGTGGAAAAGA


AGATAATTCAACATTTTAGCGAATAGAAAAATGTTCTAGATCCAGTTAGACTTCCTCGACTTATTTCCCAGGGGATGAGATCTCAAG


GCTGTATGTAACTCTCCATTAGTCCAGTGTAGCTGTGTCTCTCTGCAGGCTGCTGCTGGCCCAGCAGGCTGCACCAGGCAAAACCAC


TGAGCAGCTGGGAGCTGCCTTTTAATAGAAAAGCAACAACTTTGAGAAGAAATGGAAGAGGTTTAAAGGAGAGGAGACAGCGTCTGG


CCCCCATCCTTTATCTCTTTCCCTGAAAATGATGGAAACACACTTAGAGGCTGACTTTAGCTAATTTCTGCCAAGAACATGAAATGG


AGGTGGAAGTGTGCCACTGGTCACAAGCCATCCTGGAGTGGGCGTGATGCTCCCTACATGCCTCTGGGCCCCTCTGACAAGGACCTT


ATGCTCACTTCTGGCCGGAAAGCACTGTAAGCTGTCCCAGTTCTTTCCTGTAGAGAAATTCATCTGGTCCCACATCAACCTTGTGTC


CCTGAGCTTCCAGCCTCCCCCCACCCTCTTTTTTTTTCAGCCCCAGCTAGCTCTGGGATCAGCATCAAGTAAGCTTTCAAAGGTTGG


AACCTTCTGGAGGGTCAGAACTGTGTTCTATTTTCCTTGTTGCCCACATTGCATCAGAAAAGCACCAGGACTCCCCGAGACACCCTT


ATATACGTGAGCTCAAGGAGGTACTCTGGGTACTTAGCAATTCTGAAGGTCATGGAAGATGCTAAAATAGGCTCAGTGCTGGGAACG


GAACCTGGGACCTGTGTGGCTAGTACTCCTCTACCTCTGAGCTACACTACTACTGAGTTATACCCCTAGCCTTTGTCCGATTTTGGG


TAGTACAGAATCTACACATTCCTCCACAGCTAGATCATATAATGCAAGTAAGTGAGAGTTTGTGCAAGAAGACAAACTGAAAATCTC


TGGTGGGCGGGGCCCTCCTGGTGGGCGGGGCCGCTCTGTCTGTCCCCCAGCATGGACCACATGGTAGTGTATCCAATAGGTACTCAC


TCAGCAAGCAAGAACTGGTTGAAATCGTTGTAAAAATTAAATGAATTATAACTTGGGATGCTGAGGTAGGAAGATGGTGAGTTTATA


TAACCAGACCTTGTCTCAGAAAACAACAAAATGGGGTCTTGGGGAGATGGGGTCGCAGGTGAAAGCAGGTGCCACTGAAGCCCGATG


ATCTGAGTTCAGTTCCTGGACCTCACATGAAGGTGGAAGGGGAGAACTGACTTGCAAAGGTTGTCCGTTGGCTTCCACGTGAGTGCT


GTAGTGCATGCACATGCCTGCTGTTACCTGTGCACATCAACAGATGATACAAACCCAAACACACAAGGAACCAAACTGCGAGTGAAT


GAACGCATGAGTTATTTCACTGGTTCTCCCTTATGGCTCCAGGGCTAATTTGTGCCTGGCATAAAATTGGTCTCAATAGCCATATCA


AAGAAATGAATGCTGGAAGGGCCAGACACACCAGAGAGAGAGAGAGAGAGAGAGAGCAGCTCCCGTTCACAGTGGGTGGGGGAGAGT


GTCAGCATGGGCACCCGCAAGTCCTGGATTCAAGGATCAAGCTGTCCCCTTAACAGTAGCTGCCATATTGAACCATATGGCTCTGCA


GGTCCCAAATTCCTTTCACCTCTGCCTCAATTCTCCCATAGTATCATTTGGCAATTAATCATGTCTTGCTGTTGAAATCTCTTCCAT


TGTTATCTTAGTTGTTTTGGCTTGAGACATAGTATTTGTACCCCTTCATGGAAGTTTCATTAGTGGCTTGGAAACGTGCATTGGTGT


GTAATTATCATATCACCTTGATCAGCAACCCCCATCACCTCAAACTTTGTGCAGTTCTATGTGGTAAGAACCTTGGTCCTTTTCTAG


TTGTTTTTGCAATGCACCATAGTTGCTTATAACCATCGCTGCTCTAGAGAGAAAACTAGAGTTATAGTCTTTATCGCCTGATTGGGT


TTTGGTCTCTTGTCTTGATCTGCCATTTGGGTCTTGTCAGGAGCATTCCTGTCTCCTGGTGGAGAGTTGGCCCAGGGCAATGAGCAG


TGATCTGGCCTGGGGGTCTGAGGCCCTGGCTCTGAACTCTGGTGTAATATATTCACCCCCTCCCCCATGGCATTCTATACAGGTGGT


GGGGGGGAGCAGAAATTGGGCATTATTGATTAGCATTGTTTCTTTGGTCTTCCTTGGCTCTCAGACCATGTAGAGAGCCCACTTGGT


GGTCCTTGGAAATGCTGCCTGACCTCCCAACGGCCTTTGCTCAGGGCTCTTCCTGTGTTCCTTTATGACTGGAGATAGCTCTCCTTA


CAGACTCACCCCACTCAGGAGTGTGGCAAGCCCTAACTAGATGCTCTGATGGAAAGGGGCGAACAGTACTGACAGCCAGCACTCACT


GAGCCAAGCTGCTTCAGGTACCATTGATGGTCATGCAGCTCTGAGTGGCTGGGGCAGGTTCTGGACTCAGCAGACAGCCAAAGAGCT


TACGCACAGACTCTAGGCTCTCTAAGCCATCTGGGCTGAAGTTGCAGGGAGCATCCTCTGCCCTGAGCAGCAGGCCACCACAACCTT


CCCCTGCCCTGGACCTCTTTCTGCTCCTTTGCTGGCCCCTCATCCAGTGATTCTTCTGCTGTTCTCGTCTCCCTCTCCTGCCCTTGG


CTTGAGCCAGGGGACAGAGCAGCGACCAGGACATTCTGATTTATTTCTGATGGAGCTCTTCATGGCCAGAGACAAAAGCGACCTCAA


AATCTTCTGGATTGTGTTACGATAGAAACACAAGCTGTCATGGTACGGACACCCAAACCATATAATAGTGGCACAAAAAATAATTAC


GCCCATGCGACTTATGAGCGTGGAGGCAAGTATTCAACACAGCAGTAACTAGACTCTAGCCAGGTATCACATACATAAAACCTTGTG


CATAGTGGGGTCATTCTGGAAAAGCAAGGATGTTTTCTCCTTGAAAGCAAAGGCTCACAAGGGGCAGCCTGGGCTCAGGCTAACTGC


TCTACCCTGCTCCTAGGAGGAACTGGGGATGGTTTGTCCTCTGCCCTGCTGTTTCCTGTTATACCTCTTCCATGTGCTGTTTCCCGC


CTGGCTCCCTAACTCTCTTTCCCTCTCTCCTGCAGGATTCCATGTTTTCGTTGGCCCTGAAATGCCTTATCAGTTTATCCACCGTCA


TCCTGCTTGGTTTGATCATCGCCTATCACACAAGGGAAGTACAGGTATGTCACTCCCTGACTTCTAGTAGCAGCCTATCCTGCTGCC


TTGGTCTGGACTGAACCCACCCATCCCCAACCCAACTTGAGTGGCCCCACAAGATGGTGTTTGAAATCTTCTCTTTGGGTCCTCACG


GAGGGTGTCTTGAGGCTACCCTGTGACCCTCCTCTCGGGTGATCTCATAAATAGGCATAAGGCTTCATGAATCGTGGCTGTGTGGGG


GTGCACACATATATAGACACACACACACACACACACACACACACACACACACACAGTGCCTCAAACACCAGCAGGGAGCCTGCAAGT


TTTGAATGTGGAGACTCCTCCTCTGAAGCCACCAGGCTGGGATGTGCCTGTCATTTTCTAGCAAGAGAAGATGTAATGTGTGATGTG


GTTGAGGTAAGGCCTCTATTTCTGGCTGCCTAGGGTTGGTTCAGTACTCTGGGAAATGTTTCCTGGACATCTGGGTATTCACCCAGC


TTGGCTGGTTATATAGGGAGGTTGGTTCAACTTAAACTGTGAGACTGAGGCAGGATTGAGTGGACCCCGGCATCCTCTTGTGGCAGT


GAGTTGTCACCCTTCCCCCACCCCCGGGGCCTGCAGACTGATCTGCTCACTGCTGACCCAGGTCATCCAAGATATCCAGATGTTTCT


GATCATGTGTGTGTGAATCTGGATACTCCCCCCGCCCCCGCCCCCCATCTTCTGGTCAGAGGAGCATGGACAGAATTACATCTGGGC


AGCAGGAAGAGACTGACGAAGACCAGAACTCAGGAGTCAGAAAGACTGGGGTCAAGTCTTGGCCAGGACTTCTTCTTACTGTGTGTT


TTTGGCTGGTCCTGTGACCTTTCTGGGTCTCAGCCTCCTCACCTGGAACAAGGAAGCTTTATTCAACTTTGCTGGGCTCCTGTGAGG


GTAGAGTAAAAAGGTTGTGTGTATGTGTAAATGCTAGCTGGCATGCTGGTAAGCTTAGGTCCATTTGTCCTCATTGTCCTGACACAG


AGATATCATGGGGAGCCTCCCTGTCCCTGGGTCCAGCTTCTAGCCAAGTTCTGGAGTTCCTGTGGCTGGATGGGATGTGGTGGTTTT


TACTGTAGGTCTTCTTCTGGCCATAGGACTCTCAGTATGTCAGTGGCATAGGACACCCATTTAGAGGCTGGACTCTAGTGTTTTGCA


GTCTTGTGTACTTAGATTGGGCTATACTTTGAGGGCCGAGTACAGAGGTTACTAGGCAACTTTTTTCATAGCGTTCTAACTGGGCAA


AGCTTCTGGACTCAAACCCAGACCACCGTCCAGCAAATCTCTGAAAGGAGCCAGTAGTATAAGTGACGATGACCAAGGGACCATGCC


AGCATGGAACCTTCAGCATTGGCTTCATCCCTACCTGGACCCAGCTGGACGGGGTTCTGAGGCTCTTCAACCTCTGGGTGCCCTCAT


GTTTTCATCTGAGATGGGCTGTGTGGGAAGTTGTCATAGAGGCCAGGTTGAAAAAGAAGAGTCAAAACTCAGCTGGACCTGGATTGG


GAGGAAGGGCAGCGGGCAGTTTCTAGCACACGGAGGGCCTCCCAGACACCTCTCCTTTCTGCTCCAGACATTGTGAGGAAGGAGCAA


GGTCTCGGATTCTCTTAGGGTCAGGCCTCTTTCCTACTTCAGGTCCACAGACCTGACCTAGTTCAACTGCAAAGCCTCTGGTCTTGG


GGGACAGAGCCATGCTGCTGGCAGACCCTAGTTCACCCTCAGCTTAGGACCAGTCTGTTTCAGCCCTAACCACGCTCTCTGGGTAAC


TTACATTGTTGGCCCAGCACTCACAGTTTTAGAGAAACAAGGTGAAATGGGTGGCTTTGGTCTTTTTAATTAATATTATTTATTACT


GATATTGATTTAATTATATAATTGTTGTTATGTGTTGTTCTGGGATGGAGCACAGGCTCTGGGCTTATCTGGCCAGTGTTCTGCTTC


TGAGCTACACATCAGACCAAAGTAGTGGCTTTGACTCCTACCTCAGTCACTGCAGGCTGGATGACCTTGGATGATAATAAATCCTCA


GTTTCCCACCCAAAGAATGAGAGTCCCACCATCCATTCTGGTGAATTCTTAAGGGTGTGGGAATGGTACCGGGAACAGTATGGTTTC


TAGAAATGGAAACCTTACTCTCTTTCCTGTTCCACACACAGCTGTCCTCTAACTTCTAGCTGCATTTTGGAATATGCCAGGTGAGCC


AGCCTCATGGCCACTAGCACTGCTGCCCAGAACTGCAAGTGTCTGGCTCTCCTCCTGCTGTACCTAGGCTCGGTTTCCATGACGTAG


ACCCTCATTGTGCTGTACCCACTGACTCCCAGGGGAAGTGACAGTGTCTTCACCTTAACACTCGCATTCTCCCTACAGCTGTCTGGG


CTGTCTCTTGTCTCCTTGAAGGGAATCGGAATGGTTTAGCCCCAGAGAGCCAGCAAGAGAGGTGTTCCCATCTGCAATCACCTGGCC


AGACTACAGCTTTCTGCATGATGGCTTTCTCCATCACTTCAGAAACAAAGAAACACAGATGTCGTTAATATTTGCATTTCCAAAAAT


ATACAATGCCTGACAGAGAGATGGGATAGAAGGTACTGGACTAAAGAACTCTTGTTTCTAAAACTAGTGACATCATGATTTTGCGTG


TGGTCCTGAGCCTCAGTTTCCTTGTCTAATTATTAGGGTCCTGGTTTTAAGTTATCCAGTCTAGGTGTGGCTGCTCATCTTTCAGGG


TCCTGGTTACTGAGTGTTTAGTGTGACTAACAGAGAGTTTCCAGGGGGAAGCAATGGAAATGCCATCCTCAGCGCAGGTCAGCCACT


GCTGGGGTGAGCAGGGTGGGAAGGCTGTGGCTGTGCCATCTCCTAAGGCCACCTGCCTAGCACAGGGCCTGCTGGGCTCTCTGAGTG


CTACAGTAACGGCCTGGGGAGGGTCACCTACCAGTGACAGCATGCATTTAGAACACACCCCATTCTGCAGAGAGGAACTTGCTCTCA


GCCCCACTCCTGTCTCTGGAGCATCAAGGACAGAGCCAGGTTGCCATGTGGTCACTTCTGTTGTTGAAGATGCTCACCCCGCCTCTC


CTCAGCCTTCATCTTTTGTGGCATTTTTAGAGTGGAGCTTTGAAAGATTCAGGTACCTTTTATCCCCAGGCCAGTGTATTCTGAGAA


GAAAGGAAAATGCAAAAGCTATGCAATTTGGACCTTCGCTAAAATGTAGCGGGAACCCATACTTGTTCATAGACAATGCACTCCTGT


GTCATTATGTTTCAGATGCCCTTGGTGCACCCCTGCTTAATGCAGAAGGCACTGGGCTTGGCTGCCCTCCTGATAGTTTGCTGTCTC


TTCTCCACTGCCCATCCAGCTCCATTATTTATTCAGCAGGGGTTTAGTGAGGTCACTCTGTGCACAGCCAGTGAGGAGCTCTTATCC


CTAGAAACTCTGACATCACCATCGCTTCTCTGAGGGGTTGCCAGCCTCAACTGTGTCTGATGCTGTCCTTGAAAGCAGGTTTTCTTT


TTCTTTCTTTCCTTCTTTCTTTTTTTAAAAAAAAGATTATTGTTTCTATGTATATTGTTTATTTATTGTTATATGTAAGTACACTGT


AGCGGTCTTCAGACACACCAGAAGAGGGCGTCAGATCTCATTACAGATGGTTGTAAGCCACCATGTGGTTGCTGGGATTTGAACTCA


GGAGAAAGCAGGTTTCTGATAACATGGATGTCAGAGCAGCCCAGCTTGGGTAGAGGCCAGGCTCTTTCACCTTTTAGGGTAAAGATA


TATGGCAGGTGACCTTTAGGGTTTTTTGTTGTTGTTGTTTTAAACTCTCCTTTACTCTATTTCCTTCTTGAAAAATCAGATTAGTGG


TAGTCCCTACCACAAGGACTGTTGTGAAGAACAAATTTGGGCATTACGAAAATGCTTCAGCTCAGATAAGGGCCTATATGTCTTGCC


CACAGCATGGGAAGGCTGTTTGTCTCAGTCACTGTTCTATGGCTGTGAAGAGACACCAAGACCAAGGCAACTCTTATAAAAGCATTC


AAATGGGGTCTTGCTTACAGTTTCAGAGGCTTATATACTCCATTATCATCAGGGTGGGGAGCTCGGCAGCTCACAAGGCACTGGAGC


AGTAGCTGATCTGAGGGTGTGTGTGAAAGAGAGAGAGAGAGGGAGAGAGAGAGAGAGAGAGAGAGAGAGATGCCTTGCATGGGCTTT


TGAAAACTCAAAGCCCATGCTAGATGACAAACTTCCTCCAACAACTCACTCCATCAAGGCCATACCTTAGACAAGGCCACACCCACT


CCAACAAGGCCACACCTACTCTAACAAGGCCACACCTCTTAGTTCTTCTTAAATAGTGCCTCTTCCTGATGACTAAGCATTCAAATA


TATGGGCTTATGGGGGGCATTCTTATTCAAACTCCACAATATCCCAAATAGAAGTCATAGAATAATCAGAAGCCCAGGAGTGGAAAC


TTCAGTGTCTTGTTCAGAATGTCTCCAGGCTAAGGTCTCAGACAGTGCTGGGGGGCGGACAGTGATCTGGGGGTGGGGTGGGGTGGT


GGTGCTCCATTGTGGAAGGTGGGCAGGCCCAGTGGCACCTGTTTGTCCTGCTAAGGAGCTTTGAAAGGCAGTAGCAGGAATCACAGA


AGACTGCCAAGCCGGAGGACATTTACATTTTAGACATGCTCTCTGCTTGCGAGTCTTAGAAGAGTCAATTTTAGAGGCAGGAAGATA


GTTAGAAGCCGATTACAACATCCAGGTGAAGGACAGTGATGCCTGACCAGGATGAGTACAGGAATGGGGACAGAGGAGGGAACATGT


GTTAGAGAGGCTGAGAGAATGGAAACGACAAGACTTGGTTACCAATTAGGGTGGTTACTTTCTTGGCAGGGAGAGAGAAGTCTCCCA


ATTGCTTTGGATAACTCAGTGCTGGAGAATGCCATTCATTAAAACTGAAAACACAGAAGGAGGTCAAGGTGGGACGGGTGTTGGGTT


CTACTCTGGCTTGGGGGGGGGGAGCTCTGGCTGCCTCCAGCGTGGGAATGGGAGCTAATGATGTCGAGTAGTTAGGGATGGGTGTGC


AGGTGCAGTGAGATAAAAGAAGGGCGCAGGGCAGAGACCCCAGAGGAACATTGACAGGTGATAAGTAAGTGGGGGAGGAGCTGCTAG


GAGACTGATAAAGATTACAAAGAGGGAGGACAGGAAGCAGCCTTTGCATCTGCAGTGTGGAGGGCAGGGCTGAAGAACACACTGTCC


TCGCCCTAACTTATTCCTTGTCATGACAGTCACTGGGAATGGCAGTGTAGGTGAGGGGGCAGACTGAATAGGTGGCGGCAGGGAACA


TAGACTGTTGGTGGGCTACCAGCAAGGAGCCAGCTGAAAGGGAGAGGGAAAACCAGGGGTTTACCTTCTGATCCAGGAGCCTGCAAG


AGAGGAAGGGTAGAGAGCCCCAGGGAGGAGGTGCTGGCTTAGGCTTGGGGTGTGGACAGCAGAGAGAATTCACATCACGAAGCCCCT


GGAGAGAAGCTGCAAGCACCATCAGTTACAACTTGTGTTATTTCATTAGCTGACTCAGGGGGACAGGGCTTATCTACTCCCTGTCTG


GATCTCACGGAAGCCTCTGCACACTTCTTTAGTTTCCTCTAATGTGACAGAAACATAACGATAGTGATAAGATATGAGTCTTCAACT


TTATGAGTTTGGAACCCAAGGGACCCAAACTGGAGATTTTCATTTATTAGGTATATAAAAGTGGATATTTTTTATTAAATACCAATA


GGGTTTTCAGAAGTCAAGGAACTTGTTTAAAATTATAGGCCATAAATTATAGTCAAGAGACAGCTCACATTTGTAAACAGCTCACCC


ACTGTGGTGCTGTTGTCCAGGAGATCCAAGCAGCCTCCTGGGTGATCACAATGTACTGTCACCAAGACACGATGCCTGTGATACAGG


AGGTGTCGCTGGTGCAGACTCTTTGGGGTCCTTTTGCTAAATAGGTTAGTGGCATCTTCTCATCAGGGGACAGGCAGACAGTCCAGT


CTTTCTCTTTGCCTCCCTCTTCCTAGAGAGAAGTGAACTCAAATCACATTCTGAACTTAGAAGGTGACCTGGCCTTAAGAGGAAGGG


TGTGACAGCTGCGTTCTGAACTGATGTCTCTAAATTAGCGAGTTTACCCACATGTGATTTATAACACTGAGCCAGAATGCCCATCTA


TTTACTTAACGCTCAGAGCTCATTCTACACTCCTGCCTCTGGGATGTGATTGACCACCACCTTGAGCCAGCTGACCCATCGTCTTAA


GCACCATAAGAGGAGGCATGAGTCCACGTGTCAGGAAGGAAGAAGCAGTGGGGCATGTCTCCTAGAGGGGGTAGGTCAGTTTCCTAG


GGAGGTGAACCTGGGCGCTGGAATCACTTGGAGCAGGGACCTTATGTGTAAGAGACAGAGCTGGTCTGGAATTACACAAGAAGAGGA


GGAAGAAGTTATGCCTTTCTTCCATGGGAGCTAGAGGCTGTCCGTCCTTTCTGCAGATACACCATAGGCAGTCCTGAGGGTGGAATT


CCTGGATGCTTGATTGATGCATTTGAAGTACTAGTTCTGGGGCTGAGGAGATGTCCCAGTAAAGTGCTTGCCAGCCAACCATGTGGA


CCTCATTTTAGGTCACCAGCACCTACGCAAAAACTGGGCTTGGTGTGTTTGCAACCTCTGAGGGGTGCATATGTGTATGTATATGTG


CGTGTTTCTCTGTGTCTGTGTGTAGAAAGGTAGATCTCTAGAGTTCACTGCCAGTCAAGTTAGGAAAATTTAAAAGCTCCAGTTTTA


GTGAGACACTGTTTCAAAGAATAAGGCGGAGAAGGACTAAGAAAGATAGCTGTCTTAGTCTACTGTGGTGATAAGATGCCATGATCA


ACAGCACCTTGGAGAGGAAAGGATTCATTTTGTTCTACAGCTTATAGTTCATCATCCGGGGAGGTCAGGACAGAGGCTTAAGGTAGG


AATCTGGGTGCAAGAGCTAATGCAGATGTCATGGAAGAATACTGTTTATGAGTCCGCTCAGCCTGATTTCTTATAACATCCAGGACT


ATCCATCCAGGGGTGGCACCACCCTCTGTACGATGGGCACATTAATCAAGAAAAATGCACCACTGGCTTGCCCTTGGGCTAGACTTG


TCGGGGAATAGTTTTCATTGAGGTTTCTTCTTCCAAAATGACTCTAGCTTGTGTCAAGTTGACACAAAAAGTACAAAACCTAATGTT


GATCTCTGACCTTCACATGCATGTGAACACACATGCACACACACAAGCACACGCACAGGCACAGGCACACACGCACACACACAACAC


ATGAAATGAATTCCGGCTCTGAGTTCCTGAGATACGAAGAGCCTAGTTTCTCAGCATGGCTTGATCTCAGGGTGTCAGTTCAATCCC


AGTGTGGTCAGCACAGAGGAGAGCAGGGCTCAGGTGGTTCTCAGGGGAATCCAGCCTGACAAGGACATTCTGTGTGGCAGCCTCTTC


TGCCAAGTGTGTGTCCATCTCCTGTTCCACTTTCATTAACACTGCATTGATAGATCACAGCACACGTGAGAAACAGAAGATGGGAGA


GGGTGTTCCAGGGACTCAGCGCGGTGCTGTTTCTCTTGGGATCAGCTTGTGCTTGATAGGGCTGGAGAGAAGGAAGCAAGAGAGGAG


AGCCTGCCATGAAGACACCCACAAATGCCTGTACCCCAGCATTCAGGAGGAGGCAGGAAGATCAAGAGTTGGAGGCCTGAGCTACAG


TGTGAGATCATGTCTCAATAAAAGAAGAAAGGAGAGAGTGAGAGTGAGAAGGCTAGAGAGTGAGGAAGCGAGAGAGCGAGCAGCAAG


AATACAGATGCTTGGCTTTTGGCAGGGGACCAGTCCACCTTCTTTGAAGATAGGAGACTTAGTGGCTGGCACGTGGGCAGTGCCTGG


GTGGCGTTGGTTGCACTGTGCCTAGTTGGTGCTTTATAATCTGGGAGTGTCCTCACAGACCTGCCCCTTCACCATCTTCACTTTTAG


CCTGCAAATCCCTCCTCTAGGAACTGTCTCTGGATACCTCCAGTCTCCAAGCCAGGAGCCTGTCTAGGCTGTGACTTAGCATTAGCT


CTTTGCCTGCTGCGGCATGCCTGATTGGTAGATGGTAAATGCTAGCTTTAGTCAGCCCCACTGCTCTAGATGTGGGCTTCATGGTGA


TGGAGACTGTATTGGAGCTAAGAGATGTCTGTCTAGCACATAGTGAGACTCAGAAAGAGCGGCTGAACAGCGAGTGAGTGAACGGAA


CACAGATGCGGTCTTTCTTCCTTCTGTGGAGAAAACTCATCTCCAAAAGACTGGACTAGTCTCAGTCCACAGTGCTGGGTTCTGGCT


CGTGAGTTTTGTATCCCAAAAAACAAAGGTCTCAACAGGCTACTCTTGTGAATTGGTCTTGCCCACTGCTGCTCTCTGGTCCTCTCT


GCTGCACTCTGGTTAGCCTTTCTCACGCCCCGGCCATGAATCGCCATGGTTACTATATCAGCCCTGATGGTCAATTTTTATGTGACA


CTGTGTCTTTATTTTCTAAATATTTAAACACTCGAGCTTAACCCTTTTGCCTCATAGCTGGCTTCCTGCCTCTGTTCCACTCAGCAG


GCATTAAGATGCCTGCTCTGCCATGATATCAGGGGCGAGCGGAGGGCCAGGCTCTATCTTGGCTGTTGGTACTGATCTCCAGTTTTG


TCTCTGGGAAATGGGTATCCTGAATCATACTGTTTCCTAACAGAATGTGTGCCGTGCTTATTAAAGGTATGGAAACCCATATCCGGG


ACATGTTGAGACTTGTCCCAGCCAGGATAAACAGCTCTAGACTTCCCAAGTCCACTTGCTGTGTGCCATTGACGATGCCTCTTTAAT


TGTGGGAGAGGATGAATGAGGATGTGTGTGTGTGTGTGTGCTCTTTCACTTATATGTGGCCAGAGGTTGACAGTGGGTACCTTTCTC


TGTCCTTCTTTTGAGCCAGGGTCTCTCATCATTTCCCCTAAGCTGACTGGCCAGCAAATCTCCAGAACGCACGTGTTTTGTGGACTT


ACAAGTGCATATGGCCGCTACACCCAGCTTTTAGGTGGGAGCTGGGGATCTGAACCCAGGGATTCACGCTCGACGCTTGGACAGCAT


GCAGGATCCTCACAGAATCATCTCTCCAGCCCTGCAAATTCTTCCTGCCAACTCTTCCAAAATCTTCCCGGGCCCTGGGAGTCTCTG


TCCTAGATCCTGACGGGGCTCCGGGGCAAATTAGTTTGGGAGGAATTATGTTTGTAAGTGGAAGGTGACTTCTCCCTTTTCTTCTCC


CCTCACTGGCTTGAGACAGGCCCCAGCACCTGAATATAGGTTGCCTTGGAAACCACTCAGTTGTCTTCACCCTGGGCTATGTCAAAG


GAGTGAACATTGGGTGTGCTGTTCAGGAGGCTTCAGCAGTGTAAAGTGTCATCATACCACCAGGGGGACTGAGCTAGTGTGAAGGGC


CTCCTATCCGCCCCACCCCAGGGCTCCGGCTCCAGTGAGCTCTGTGCTCACAGGATGTAATAGCCTGTGTCTGGAGTATTGGTCACT


GTAGCCAGATAGGCCACCACTAGTTCCACTTTATTTTCTTTTATTTATTTTTTTGTGGTTGTAAAGTAGATAGATCAGGCCAAATGA


TCTCTGGGGCTTCTGATTCTGTGAAGGTACCACAGCTGAGGGACACTTGATGACTGGGAGATAAAAACCAGAAGGAAAGTGGCTGAG


AGCTTCAGAGGACAATGACAGACAGTGCGTGGTCAAGAGGCTCCTGGAGGGGCCTATTTGAACAACCTCATCTTTCTTTTAACAGCC


TCGCCTCTTTCTCGGAAGCAGAATTGGACACCTAGCTAATGGCCTCAAAGTTGAAATAGAAAGCCATCAAAATGACAGTTTTTTGGG


GGGCTCTGGTATCTTGTAGTTTAAAAGAGACTTCTCTCAAGTCTTTCCCAAAAACAAACTGACCGGCCTTCTTTAAAGCCTTGAGAA


TGATCACGGTATGTGCCCAAGCTCCCCCACCACGCAGTTCCAGCCTCCTTCTCCAAAGTCCCTGGGCAGCGAGCTCACATCATGAAA


AATCTGTCTCTGACTGTGGGGACTTGCACGTCTGAGGCTTTTTCAGAGTTAATTCATCCAAATTTGTATTGCTATGTTGTGTGTATT


TGTTTATTTCTTCATTTGAAGTAGCTGGGAACTTGTGGCTTTTCCTGCCTCAGCCTCCTAAGAGCTGACCTGATTTTCAGACGTGTG


CCACCATACCCAGTTATCTTCCTCCTCTGTTTATTTGGGGCTATTAATATAGGGGTCCCACTTAGGGCTGAGCACTCAGTATACATT


GATTCTCAGTATTATGACTAACTATTGATCTCTGCATTAACTGTGACCACTGCTCAGAGAGGATTCTTTGGCTAATGTTAAGCACAG


CACTACGCTATGGATCTAAGCATAGATATTTGGAAGATAGTTTGACAGCATGTCATTTAGCAAAACAACAGTAACAGGTTGTCCCCT


AGGGCCTGTGACCTCAGGACTCATGGACTTTGGACCAGCACCAGGCCCAGATTCTTTACTGTGAACCCAGTCTCAAATCTAACCCTA


AAGCAGCTGGTTACATCTACAACCTTTGTGCCACTATTGCACTTGTGGGCACATCTCATCCGGCAGATTGGTACTATAGCATGCAGG


GATGGCCTGGCTACCACCTTCTGGCATGATGAAAGTTAGTCAGCAGGGTGGGGGGATGTTTTCAAGTTTGCCTGATTTCACTATGTC


CTTCAATGAAAGTATGTTGTACCTTCTGCAATTGGGTTTTACAGTTTAGTTTTTCAGGGAGGAACAAAGAGCTATGGCAATAGCTCG


GATTGTATTAAGGGCCTATGGGACCTTCCTGACCCCATAGGGAAGTATCCTATACTTGGTACTGAGGTTTTTATTTTTATTTATTTA


TTTATTTATTTATTTGCCTTTTTTTTTTTTTTTCCTTCGAGACAGGGTTTCTCTGTGTAGCCCTGGTGGCTGTCCTGGAACTCACTC


TATAGAGACCAGGCTGGCCTTGAACTCAAAAATCTGCCTGCCTCTGCCTCCCAAGTGCTGGGATTAAAGGTGTGTGCCACCATCGCC


CAGCTTGAGGTTTTTATTTAGTAATCCATGACTCACAAGTCTGACTCTGCAGGGTATAGCTACCATATTTAAATGTTGATCTCTCTC


CACAATGGTGACAATCCTCCATCAGCAATGTGTATTAGCCCCACTGTACTGTGTCTGGCCTCCCACAGGCTATGAAACCCCACTTCC


CTAGGGGTATGCGCTTTGACAGCACCACCAAGGTTCTCTGCACACTCAGAGGAACAGTAGCCATCTCTGTAGTTGCTCCTTCAATGC


CTAATACACAGCAGGAGCTCGATGATTCTAAAGTGGGCGAGCAGTATCTGACTCTGAGGATTTGTAAGATGGGAAGACACTGCACAG


TTTTTACCGTCTAGAAATTTCTATACACTTGTTATTGCATTATGCTGCCAAGAAAATTCTGGTAATTCTAGTTTCCTGTTGGGCAAG


GAGCTAGTCAAGTGACATTTTCCCGTTTCTAAGAAGAAAGATGGCGAAATCGGCACTGCTCAGATCCTTCTAACACAGTAGTTGGAT


TAGGAGAAGACAGAACCCATCCTTCATTTCTATTTTGTTTAAAAGACTTGGTGCAAGTTAGAAGACATTCCATCACTCTGAAACTTC


CCCTGCCAGAGGGGAGGGACACCCATGGGCACTTGACCTGGGTCTAGGTTGGATTTTGTCATTTATTTCTTTTTTCTTTTATTCATT


TAATGTATATGAGTACACTGTAGCTGTCTTCAGACACACCAGAAGAGGGCATCAGATCCCATTACAGATGGTTGTGAGCCACCATGT


GGCTGCTGGGAATTGAACTCAGGACCTCTGGAAGAGGAGTCAGTGCTCTTAACCACTGAGCTATCTCTCCAGCCCTTAAATTTTTTT


TTCTTAAAAATGGTAGTAAAATATATGTAACATAAAAATTTGCCACTTTACAATACAGTTCAATGGCATTAAGGGATATTCATGTGT


GGTTCAAGGATTATCATCAGAATTGACTTCATTACCTTCTATGTAACCTATGTGCTTTGATACAAAATAGATTTGCTTCATGCCCTC


ATTTGCACAAGCATCCTTTATCATCCAGCTCCTGACCCCACCTCCATCCTGTGTAACACACTGTATCTCAGGCTGTGGTCCTGTTTC


AAGCCTTGGCCTGGCATGCAGCTGCACACACGGCGACAGTGGCAGCAAGCCACATGTCCATTCATCTCATGTGGGCGAGGGATTCCA


GTTATCCTTGACAGCAGTCTCATTTTACAGATAAGTGAAGTGAGGCTGAGAGGGGAGAGATTACCTATTCAAAGTCACGTGGCTGAT


GAGAGGCAGAGCTAGCCTCAAACAGACAGCCATCTCCAAATCCTGCAGACTTCTTTGCTAGTTGGGGTGCACTCCACTCTCCAACCC


ATCCGTGCCCCTGACTCCTGTGGTATCCAGAAGCACTCAGGAACACGGGTGGGTTGTGGGACTTAACATAGTGGAGAAGAGTGAACG


TGATGGGGTTCTGGGCTGAAAAGCAACGAACACAATTGGTCCTACCTTTCAAGCTCCCGAACACCTTGGCATCCCCATCTGCTAGAA


CCTCGTTCTCTTTCTGGTTTTCTTGCTGTCTTCCCCTTGGGCCCTACAGTTGTCTAAGAGAGGGGTCCAGTTTCCTGAGGGAAGAGA


GGTTACAGTGTTGGTGATATGCCTGAGTTTCCTTGCTGGCCCTCCCCTTTCTTGCACGTGTAGGTAGGTGCTGGCTTTTCTTGCACA


CTGGCTGCCTGGCTGAGCCCTATAGAGTCTTGATCTTGCTTGCCTTCCTGCCCCGCTTGGGCTGACACCCATTACTTGTGCCCTCCT


CATCTTGTCTGGAGTCACTAGCCCTGTTATTTCTTGCATTCTTATTTGCTTCAGCCCAAGGCCCTGAAGACTGGACAGTCTGGGGCC


TGCTTTAGAAGTTTTGTCTTTGCTTGCTATAATCCCACAGGCCAGGGTTGGTAGCCTTCTCAGGCTCTCTACTCAGTGACCATTCTT


ATGCTGTGCATCTGCAGTCTTATACCCAAACCTCCTGAGGGGGACCTAGACCTTCCCAGCACAGTGTTTTTCCAGATAGGTCTTGGG


GTCCTGTCCATCGCGGCTGCTCTGAACAGATCCCATTAGTGCTGCACTGGGTCCATGCACCACCCTAACCTGGACAGAAGGGGGCCA


ACTCCTGGTTTTCTCATTCTCCTGACTGTAGCAAAGATGGCTTCCACGGCAGCTCATTGGTTCATTCAAAGCATGCTGTCTTCATTG


AGCTGATGATCCTTCAGCTGTTCACCGGGTCCCTCATCCTGTCATCTCTGTTGTAGAGGCAGCTTTTGGGGAGGGGAAGGTGAGGGA


AAGCTGCCCCTTTGGTTGCCCCAGTGAGATTTCCCTTGAGTTTCTTTTATCTCATTCAGCAGCAACGTATTTCGAGCAGTCCCAGCT


TCCTGTTCTGTTCTTGGTGTAAAAGCCTTGTTCAAATCACTGAGACAGATGTGGAACAAGAAATTGAATCTGGGACAGTCGTTTTCT


TTTGTTGGACTAAACAGAGGGAATTGGGATTAAAAAAGAAGCCCAAATAGTTGCAAGCCTTTTATTCTAAAAATCAGTGGTCTCCCT


TAGGCTGCAGTATCCTGCCCCTGTCCGCCCCACCATTCCCTACACACCAGGCACACCTGTGAAACACTCATCTTCTGTAACCAATGC


TTACTGAGCTACAGTGCTTGCTTGGTGCTGGGAAAGCAAGCTGCGCCTGGGCTCTGAAATTGGGTGACACATGACACTTGACCATTT


GGTAAGACTGTGTTGTAACAATGTTGCTCCAACAGCCTGTGCTACAGGAGAGTGTTGACACAGAGCCGCATGCCCCGGGGCTCTAAT


ATTCCCAATTGCTCCTCCCCAGCAGCTGGGCTTGGCCCTTGCTGCTGACCTGTGACTAAGCTCCCTACAGCCACAAAGCAGGGATCA


GTAGCCAGCCACGGTGGAGCCGTCCGCCAGGTGCAGAGCAGCCTCAGCCTCCGAATTCAGACCATGAGGCAGCATCGCAGGAGTGAA


GGCATAACATCCAACGTCCCGGACACCTTTCTGCTCACGGACCCCACCCCTCGCTTCTCCCAGTTCCTTCTTGGGTGTCACTGGAGC


AGGAAGCTAAATGTTCCTGTCAGTTCTCTGCGGTACCACTTGTTAGAATGTACTAGAAGTGGTAGCCCTTTGAGAGCCAAGAGGAAT


CGCCTAGGCTGGGCGTGTGTAGGATGGAGGTGGGGAGGGGCAGGCCAGGCGATGTTTGCCTTCCCTCTGTTGTTAGAAATAGCAACC


GTCCTCCACCTTGCTGAAGGACTGGACAAAAGGTGATTAGTCCCCTAAGTAAGGGAGCTATTGAAGGTCTGTTCAGAGCTAAGCACC


ACAGGGGACAGCAAGGCTCTGGTCATGAACAGGCTTGTGATCTAATCTGAGATAAACATCTCCACTTGTAGGCACAGTGAACAGCAA


GGGGGTGTGGGGGCTTCCCACTTAGGTGGGAATAAGGACCTCACACTGGTGCTGAGGAGCAGGAGGACAGAGAAAGCTGGAGCAAGA


GAGTGTGGGGATGGGTGGGTCCTGTAGGGGAGCGAGCCTGCTGAGCAGCCAGGAGAGGTGGCTGGGAAGAGGGTTGTTTGTGTGTTT


GTTTTGTTTGGTTTTTTTTTTTTTTTTTGGTTGGCTTTTACCATGTGGTCACTTTTAACCAAGATTGGAGTTAAGTCACACGGGTAA


AACCCACTCTTTCTAACCCAGCAAAGATGGCTGTCAGCCATGTGGCAGCAGCTAAGACAGTGGCAAGCCTCCTAGTGCTTTGAGGAA


TGGAAAAGATACAGATAAGTGTAAAGGGACTAGAGAGAAGTGAGAATGGCTGGGGTCGGGTCATCCCGGTGAGTCTAAAATGGTGGC


AGCCAAAAACGAATGTCTCCAAGCTGCTGTGGCAGAGATTTTAGGAAAGAATGAGAGCTCACTCATAGCTTATCAAAGACCAACGGG


TGGCAGTGGCAGTGAGGTGAGGAGACAGACACACACGTGGGGGACATAGTTCCCGGGTCACAGGCGCCGGCCTGGATTTCCAAGTTC


AGGTCTGTGCTGGTTGAAAAGTCTCCCATGTTGGAGATCTCCAAGACCAGCTACCATATGCACTTGGTTGAGAATCAGGAATGACTA


GTCCTAGCCCTAGAATCCAGAGATTCCACATCCCATCAACAGAACACGCTCCCAGGGCAGGGCCCGCAGGAACCCCAGTTTCTCTCG


CACTGTCAGATCTTTTTGGATGGTTGGAAGGAGTAGCGTCCATCAGCTTTACAAGATTTTACAGGCTTGCTGTTCTCTTACTGTTTT


CAATTACCTCTACCTAAAAACACATCCGTCCCCAGCAGCTTTGGGGGTCTACCTTCTCACAAAGGCAGGGTTTTGAATGGGTTTCCT


GCCTTCCAGATTCAAACTTGATAGTCTGGCCAGGTGGCTGAGAACTGCCATTATCCCAGAGCGGCAGCGGCAGGGGCTCCTGTGCAG


CTGTGAGTCCCCCAAAGCCAGCATGGACCATCTTGTGTGTAGTGGGTTGAGAGAAGGTGTGTCCACGTTGGGGTCACGTAGGAGGAG


ATGTGCTTGCTGGGCCTGGGCAGGAACTCAGGGGCATGGCTGTGGCTGGCCCACAGAGCAGAGGCCTAGCTCACAGCCTGTTTCCAT


TTCTCAGCTTCTCCAGCCCTTTCACTAGTATTGCCCAGCCCCTTCCCTCCTTCTTTATGTTTTCTCTGTCTTTGACTCTCTTTTTGT


GACTGCTTCCATCTTTTCCTCTTTGTGTGTGTGTGTTGAAGCATGCGGTGTTTGTCACTGTGGGCTGACTCTGCGTCTGTGTGTGCT


TGTGTGTGAGTGTGGTCTTAAAGCTGGATTGACAAGGGATGGGTTTTACTTCCTGGCTCTGGAAAAAGAGAGGGAACGACAGTGAGG


GACAGGATCTCTGAGGCAGAGAACATTCCGATCTAGGTGTGCTTTGGGGGATGAATTTAGTTCTCAAGATGGCTGCGATGTTCTAAT


TGTGCAAGAGTCCTTGAGCACCCACAGTGGGGGGTGGCCATGTTGTCCCTCATCTGCTGGCTCAACTTCAGGGACCACAGGAAACCC


CAGGCTTCTAAATGTTATGCAGAGCTACAGTTCCAGCGGCCCTGAGCTGACAGAGATGGATGCCCAGCATTAGAGTCTCTCCAGGCC


CCTTTCTAGGTGCTCGCGGTTTTGGGAGCACTTCAGTTTTTATGGCTGGCATATCTCAAAGAGGAAATGCAGATTAATGGTGTGTTC


TGCCATGTTCTCATGTTCCTGGGACTAAATCAGTAAGATCTGAAATATTAATTGGGCTTTTATGAAGAGAGGATGAAGTACGGCGTG


GCATGGAATATTCTAGATTTAGGATCATGAGTTTGACTGTCAACCCTGCTGCTGCTGAGATTTGCTCTCTACTGAACTGCTAGCTTT


CTCCGAGTCTGTTTCTTTCCATGTATACCAGACTGGGCACACACCCGTGTTGTATCAGCTTAGAATATCACCAAGCCTGGCACAGCC


AGGGGCTTTTGGTGAGTATATTCTAATTGCCTCTTCCTTGATAAGACCGCCCTTAGCTCACGACACAGGATCCAGTTCTTGCCTGAT


GTGGGTACCTGCTGAAGCTTTTAATGGATTCAGCCCTTTGATGAGGTCTCTGAAGCCCTTGATGGCCATCCTCAGGGGCTTCTCATA


GCTGTGGTCAGCACACTCCTAGGGGCCTCCCTTCATCATCCTTCTTCTCAGTGTTGATGGCCAGCCTAGGGCTGAGGGGAGCTTCTT


ATCCCTCCTGTTAAAGATTGGCCAGTCCCATTGCCCGACTCAGGTCCCAGATACAAGCTTGTTGTCAGTACATGGGTCATGGAGCCC


TCAGTGCCCTAAGTACAGGGAACTGGTTCTCATTAAAGGCGCCTGGCTGGGTAAGATGGTGACAGTGAAACAAGGAAACATTGAGCA


CAGGGCCCCGTGATGCACAAACAGGATCTTATTTAACCTTCATATTATCCTCAATCTATTCCCATCTATTTTGTATTTGCGGCTGTA


GCTCGAGCCGCCACACATTTATTATCTTACACTTGGGGATTGGGGTCAGAAGTTCAAAATGGCGCCAGCTAAAGCCTAAGTGTTGGC


AGGGCTGCTGGGGTAATCCATTTGCTTGGCTTTTCCAGCTTCTGGAAGTGGCTTGCCTTCCATCTTCCAAGCCATTAGTGGCCTGGT


TGAGTTTTCTCATGCTGTGTCACACTGCTGCTGACTCTCCTACCTCCTGCACTGTATTTCAAGGGACCTTTGTGACAATATGGTGGC


CATCTGATAATGCAGGGAGAACTCCACACCCCACAGACCAACCATCTTATTGAGTCTGCATCCCCCATTCTTCTTTGCTGTGGTTTG


AGAACTGGATGTGAGTGTTTGAGGGATGCTGTTGTGATTCCCACGGCCCCCTTCTTGCAGTTGAGGGAAACCAAGGCATAGTTTTCT


CATGGGATATTAGCTCCCACGGCCAAGGTTATGTGGCTGCTAAGTGGCAGACTGGAAGTAGAGCGAGAATTGGTAGATCCAGGAAAG


TCTGAGAAACACACTAGTGCAGGCTAGCCCTCTGCCCATGGCAGTCAGAGGAGAGGGGACAGAAGGCGCCCTAGTTTGAACCCTAAC


TCGTCTTAGTCTAGAATGGGGAGGACAAACTGGCCTGGTGAGACACTGCAGGAGAGGCAGTGGTTCTTCAACTCGGCTGTACACTGG


AATCACCCTGGGAGCTTCCAAATGATACCAGAGCTTCGCCCCTAGAGAGCCGGGCTTAATTGCTCTGGGGAGACCCTGAGTTTAGGG


ATTTCCCAGGCTCTTCAGCTGATTCTGGAGTGTAATAGAATCATCACTTTCAACTAATCCACAGCCCTGGCTGTGCCTGTCACCCGA


GTAACTGCATCAGAGTCTCCTTAGAGTTGTCTGCAGCCCCCTCCCATTCTACTCGGGACCCTGAGCAGCAGACCCCTCTGCCCTGCT


CTGCCTCCGTGTAGCCAGGGCTGTAGGCTAGAGGACATCACGTGTACCCAGAGGAGCCAAACCTTTGTGATGAGCAGGTTCTTTTCT


GGGTCTCCCTGGTCTCTCTTTCAGGGCTGTCTGCACAACTGTCCACTTCCCCTTTGTTCATGTTAGCACACTACCCAGGTTCAAACC


TCAGCCCGTCAGGTCCTGATTTAGCTTGGACCTCTCTGTGCCTCAGTTCCCTCACCTATAAACTCAGGATGCTAATAATGCTGTCCT


GGTCAGTGTGAAGATCAATAGCTTTGCAGATGAGGGAGATTACAGCGAAATGTTTGCTAGTGTTACCCGTATTATCACCTAGCCCTG


TGGGCCCAACTGATTTCAACAAACATTGATTCTTTCTTTACTTAGTGCAAGGTTAGGAAAGGGTAAAGTGTCTTCCCTGCTCTGAGA


TAGCTCGCAGTGGAGGAAAAGGTAAGTCAGTCAGATCAGACAGCTAATTACAGTACAGCATTCGATGCCGGAACCAGATGGCGGTGA


GAAATAAAGGCAGGGAAACCGCCGTGCAGGGAAGACGGGGGCCATGGATGTGAAGGCACACCATTAATTTTCAGCCATAATAAAATC


TTAGCGAGTTTTGTCTGTGTCTGCACATTTGAACTTGCGGGTTATGATAATCTGTCAAGCCCCTTAGACCAATACCGTGAATCCAGG


CGACTTACAACAGCATTTACTCTCAAGTGCAAAAGTGCCAATGGGGCCCCAAGGTCCCCTGTGAATTTATGTGCTCTCTGCAAGAGG


ACAGTTACATGCTCCTCAACAGGGTGAATCCTGTCTCCTCCTCAGGAATCCCCCGGAGAGCATCAGGAATCATTGCAGAGGTGACTA


CGTCATGCAGACAAAGGGGCCCTGGCAGCAATGAAAGGGGCCATAGCTGCAATGATGAGGGTGTGAAAGAAAACTACAGACACACAG


GGTACGAGGGCTTTAAAAACAGACAGAGTCTAGGTTGCAAATGGTCAGAATAAGTCAAAAGGTTACCTAGCTGGGGAATGAGGCTAG


GGAAGAGGAAGGTCTTAGCATGACAGCCAGAGGGAAGTCAGATGATGGGGGCAGCTTTAGGGGGAAAGGTTGCTTGCAAGGCAAAAC


ATGTCCTTCCTGTTCCCTCTGGCCAAATGGCCAGTGGCTCCACTCACACATCTCATCAGGAGCACTGGAGCACCGGCTTGATCAGTG


TTGGCTGATGCTGCTGGCAGCTGTGGGCGTCTCTGCCAGCTGTGTGAACAGCTGTGCACCAACCCTGGGCTCTTCTATGCCCTGGCT


CATTTCCCATCCCTGCTTGGTTTAATACACTTAAAAACAGGATCCCACACTCCCTGGTTCTAGCTGTAAAATATGCTGTTCAGAGGA


AAAGAGCGTGTCTGCCTGGGCAGGACAGTGAGACAAATGCTAGATAGACGTGTAGGCTTTTCTTCTTTTGAAGAAAATCTCTGTCTG


AAGCAGACGGGTGTTGATTAGTGTGTTTAAAGATGGTGCAGTAAGGGCTAATAACAACACCAGATCGTTACTGAATGGCGGTTGTCA


ATTCTGACTGCTTCTCACAGGGCCCACCTCCGTTGGTGCAGCTTGTGTGCTGACCTTCAGCCGAAGCCCCAAATGGGACTTCTAGAA


ACCGTTTACAGTACCCTGCCTGGAGTTTGCCCAAGCATTCACAGATCCACTAGTTTGGCTCACCCGGAGTAAGAAATGGCCTTTCTT


CCTGGGCTGCTGGAGTCTATGAGATTCTGCCGAGGGAAGAGAAGCCTGGGACTCCTGGGTGGGCAGAGTCAGGATTTCTGAACTGTT


CACAAGGCCCAGTCAAGACCAAGGCCCAGGGCATGCAGCTGGCATGGAAATAGTGGCTCCATTCCCAGTGAAAGGTGTCAGAGCCTT


GACTTGTCAGGGCACAACATGAGAAGACCCTTTCAAAGACAGCCTGTTTCTTCCAAATGATCAGACATCCAAACATCAAGCATCTAG


TAGTAAACTCCAGGCTACTGTAACCGTTTCCTGCGCTGTAACATAACACAACCAGAAGGAGTGATAGGAGCCTCGGGGTTCGAGGGG


TTCTGCCTGCTGTTGGGAGCTCCCTGCATGCTGGTGATAGCAGGTGGGGCTGTACAGAGACATTCTGGTTTTCTGGGGTAGAGTCAC


ACAACATATTCCTGGCTGGAGAATTATGATGACTGGATCTAACTTTTTTTCTGTAATTTTCTAGGTAATATTTGTATGTGTGTTTGT


GTGTGTGTGCGTGGGTTGTATTTGTGGGTTATGAGGTTGCCTTTCTAAAACATGGTGGCCCATGCCCTACCCAACCACCCTTGCATT


TAGACTTCAGGGCTCTGTGCCTGGCTGAGCTTTTCCCTGCCCTGAGTGCTGCCTCACCTCCACCTGCCTTGCAGTCACCAGACAGGG


GACTCTACATCTTACCTGGACCTTTTCCTGCATGTTCTGAGGTTTCCCACCTCTCTGCTCTGGAGAGAGCTGCTGGGTGTTAAGGAG


GTGTCTCCTGCCACTCTGCGCAGGTTTCCTGAGTCACAGTCTTTGTCCCTGCTGACAAGCTCGATAAGTACACATGACATTTGTTTT


CCTCTGGCTCAGAGTCCAATGGATCTGGATCTAAATTTCAGCTCTGCCTTTTACTGGCAATATAACCCCAGGCTAGTGGTTTAGGCC


TTTCTACTTCAGTTCCCTCATCCATAAAGACGAGTGCTGCTCGCATCCTCCCTAACAGTGAAGTGATGTAGTGAGAGCTGTGGGTAT


GGGGGCCATATGGAGGCTCCCGTCTCATCATCCCCCTCATCGGGACCTGCTACTGGGACCCCATATCCTTTTGTGGTGTCACAGCTT


CAGGGTCTTCTCAGAGGACTTTCCCAGGTCCTGCTGTGGTTGGCGAGTGCTGCCAGCTGCAGGAACAGCTGTACCTCTGTCTTCTTT


CTTTTGCCTCCCCTGGGTTTTTTGCTGTCACGTTAGCACGCAAGTGCGCTTAAAAATAAGTGGCAAAAGCTGTGCTTGTTTGAAGTG


TAAGGTATGTCACTCTCAGAAAGCGCATTTGTGCTGTATAATAGATAAGAAAGAGCTATCTAGTTAAAGAACTTTTGGGGCTAGCTT


TTCTTCCAGGGCGTGGGAGGAGCATCCTCCATCCTGGTGTAGGCTGTTGGGAAGAATGAAAGTGCTCTTCAGAGGCCCTGCACAGGC


TCTCGGCCTGTGGCTTTCTCATTGATCTATTTCTCTCGAGTGAATGGGCTTAACAGAAATAGAGAGAGATTTTTTTCCCTAATGATC


AGGATAGAAAAGAATAAAAAGTGACTTTAGGGGTATCTTGGGACCTTAGCTGTCATTGTGTGCTGACACTTCATTTCGGAATGTAAA


GGGCCTGCTGCTGGTTTGTAGGGATAAATGGTCTTCTAGTCGGGGGCAGCCAGGAAAGAGGCAGAGCCCTTCACTTAATAACACACA


GCATGGAGGGGCCTCTCTTGGGTTGGGTGATGGTCTCTCTCTCTCCCTCTCTCTCTCTCTCTCTCTCTCTCTCTCCTTTTCTCCCTC


AGAGAAACAAGGCTGGAGCTTGGGCCAGCTGGAGCTCGGGAGCTCAGTATAGAGTCCTAATTAGTTGTTTGGACCAAATGTTTCCTA


GTATTCCTAGGAATCCAGGGAGGGGGTTTGCTCAGTGGGCCTTGGAGACCTGTCTTGGGTTGCTGCTCTGGGAACAGGTGCCCAGGC


AGGAGGCAGCTGTATGAGACTGCTAGAGTAGAGTGATGTTCAATCACGTGAGGGTCCTTATCCTACCAGGTGACAACCAGACTAGCT


CTGGAGAGTCTTACATTTGTCCAGGACTCTGCTGTCCTGCTCTCTGTCAAGCATATATGTAGACTGCTAGGAAATTCCTGTGGCTCA


GGGATGTGCCCAGGGTATAACAAAAGGCAGGGTGGGTGCATGCCAATCTACCTCCTCTCAGGACATGCACCCAGCTCCTGTAGTGAG


AGGGTAGCCCAGCAAGATGACTTCTGCTAGTGGGGTGGTGCAAGTTGGGAGGCCACATGCTCTGTCAATAAGGTTCCCTGACAGAAG


AGACAGTTGTAATCTTAGTTCCACAGAAGCTCTGAGATCTGCAGGGCTGCTCTCTCGCTACAAGCTCCTACAGTTGATTTGTGTGGC


ACTTATGAAGCCGAAAGATACCTGCATAAGCTTCGCCAATGGGCATGAGCTTTGGACTTGGGTATGTTCAGTCACCTCCATGAGTGA


GTCAGAGACAGAGCCCAAGGATACCACAGGTCTCAGCAGCCATCTCCAGACTGTCCTCTGATTGAGCTGATGAGGAAGCTGAGGCCT


GGAGCAGTGGGAGACCCAGTACAGTCCAGACAGCCTGGTATGAAGACTTGCCCTGTTTAGTGTCCAGCACTTTAGCTAAGCCTTAAG


CACTTGGCATGAGGGAGGCTCTGCTCCACACTCACCAGTTAAAACCAGTCATTTTCCCAATCCCAGGCACTGGAGATGCAGTAACAG


GCAGAAGAGATCTGACCCTGCCCTCACAGAGTTTCCACTCCAGAGGGAGGGGAAGGGGTGGGCCATAATGAGGGAAGTCTTAAAGAG


GCCAGGGTAGCCAGGCATGGTGGTGCACCCTGCAGTCTTTAGTACTAAGGAGGTGGAGGCAGGATCAGAAGTTCAAGGCCACCCTTC


GCTACACAGCAAGCTCAAGGTCATCCTGAGCTACCCGAGACCCTGGCTCCAAAGAAGCGTTTTCGGTAAATTCGGTGAAGGACAGTG


AAGAAACCAGGACAATGGTGGAAGATGATGGAAGGAGAGATGGATCAGGCTCGGGTTTCAAGGGAGACAGAGCTCTTTGATGGTAAC


TGGAATATCGCAAGATCTACTTCTGTTAGTATTGTTTCCTTTTCCTGTATACTGAAGTATTATCCGCAGGAAAGTGAGGCTTAGAGA


CTAATTAAGCTCTCCAGTCACACAGCTGGCGGACAGAAGGACCAGGATTTGAATTCTAGTTTGCCGGGCTCTTAGCCATCTTCCTTG


GCTGTTTCCAGTTCAGTTGACTGAGTTCTGAATCTTCATAGAAATGAGGTGACCGTTTATGTCACCGCAGGGCCAGGTCTGTGAGTC


TACTGCCACTGCTCTGACACCCCCTGTTCTAGGAAAGGGTGAGCTAAATATCCCAGTGGAGCACCTCCCTTCCTTCTGGAACTGGCC


TAATTAGGAATGAGGTGGCAGTGTCCCAGGGCCACCTTATTTAGGCCACAATCTCTCTACCCTAGGCTACTCATGAATCCGAGTGAG


CTCCCTGCAGGTTAGTACCCTGGCGCACCTCCTCCCAAATGTTTTTCTCATTTCCGGTTTCACGGCTGTTTTGAATCTACCAGCTTC


ATTTCATTCATCACCAAAGCAAGGCACGCGATAGAAAAGGCGCATCCCGTCCTCTGGGCGCCGCCTCATTTCCTGCCTGAGATTGAC


AAGTGCCACTGAAGCATTTTGCACACCTCAGAGAGGGTTTGCCATTCGTGTGGCCAGAGAAGTTGTCATGCAGACAGTTGTAGGGGC


TGGGTCTGCCCTGAGGCCCCAGGCTGCAGACACAACTCAGACTGTTTTATGGACAGAGTCGGTTCTTCAGTCATGACTTGTCTCCCT


AGCCACACATTTTTAGCCTGATCGTTGTGAGCTGTCACAGCCTGCACACCTCTCAGGTTTTAACCAGTTGAACGCTCTTATAAAGTT


CTGTGGACTGGTGCAAGAGCATCTCTGTGTTCATGTGCACGTGCCCACGGTGGGAATGTGTGGAGTGTCCTTTCAAACCTTCAGCGT


GTTTCTGCTGGGGACAGGAGATGTGTACTCCATGAACTATAACTCCAGGCTGAAGAGCCCTGGAGACCAGGGAAGGGAAGCGATTCA


GACCTGGAGCTGAGGCCAGGAAGAGGGGCCCCGGCTGTGCTCTGCGAGAACTGCGGACCTGGTGGGAAAGAAGGCTCTTTGAGCTCC


TTAGTTGCTGCTCATTGTAAACCTAGAGCATTTCCCAAGGGACACAGGGCATGTTTATTAAGTTTTCTTTCTTTATCCTTTTGACAG


TGGATTGAGCCTGGGACCTGGGCAGCTAGGCAAGCACTCTGCCAGTTACTTCTCCAGCGACTAAGCATTTTTTTTTAACCATCCCAC


TCATCGCCTCCCACTGGCTCTCACGGTGCTATGACAGTGGGGTCCTCTTCCTGGTGCTCCTGCTTCCTTCCCTTTCTGTGTCCTTTC


CTCTTTCTTCACAGCTGGCCAGGCATCAGACAGACTCACACATGCAACCTTGACCTTGACCTTGCCTGCAAGCTTCCTGAGGTTACT


TACTCATCGTCCTTTTGATACAGTTTAGACTCCATGAGACAGCTTGTCTTGGAGCTGGCCCCACCCTGCTCTGAAGCCATCTTTATG


CCACCTCCTTAAACACTCTCCAGTCACTGTGAGGTTCTGTCTAGCCTTGGTCCCATATCTCTGGACCTTTGCACATGTCATGTATCC


TTTGTTCCAAATGCCATCCCCTTGTGTGAAGTATCTTTTATCTCCCCAACTTCTCTCTTCCTTGTGTACATAGACATCTCCTATGTC


CTTGTCTGCCATGCAAAAACCTCTTCTTCCCTTCCCTGAGCTCTTCAAGGGCAGCCATGGCCATACCTCTGGAGCTCCAATCTCTAT


GGCATCAGACAGAGTAGGGGCTCAGGGAGCGCTTGGTAAATGAATGGATCCCCACAATGTGTACCCACTGTTAGGCAGCAGTTCAGT


CGACCTCCGACCTGAGCCACCACTCCTAAAAAAGCCTCTTTTTATCTGCAGGGACTCAAACCACCCATGCAGAGGTGGCTTTGGGAT


ATGACTTCATGTTCCCTCATATGTCCACAAAGCATATGTCTGAATGGGCGACTAGATTCTTTGCACAATATCAAGCCAGAGAAGGGA


CCCAGCTCCCCGTGATACAAAAGGGAACAAATTCCCAGAGGTTTGTTTGTTTTTGTTTTCTTGGATGATAAAAATGTGAGCGTCACA


AGGTCACAAGAACACAGAGACTGAGACTTTGGGACTTGGCCATTGTGGTCTATCTGTTCCCCTGGGCAAGATAGCAGGGTTGTTGTT


GTTGTTGTTGTTGTTGAGACATGGTCTCACTATATGGCCCTGGTCTGGAGTTTGCTATGTAAAACAGAATGGCCTCAAATTCACAAA


GATCCACTTGGCTTTGCCTCCTGAGAGCTGGGGGGGCGTCACCTCTTCCAGGGCTCCATCAGTGGCATTTCAGAGAATGTTTTGTGA


AAGTATGAAAGAGCTCACAGGATGCCTGCATGCTTCAGTAACTCCAGTGCAGACTCATAATGGACCCACCCAGTTGTTTGAAGTCCT


GGCATGAGTACTAACTATGAAGAAATGGCCTCCTTTCTTACATAGAGCCCTGTTCCCAGACTGGGTGAGAAATCGCTCTTCGCAGGT


CAGTGAACAATGAGCTCTTCTACATCTTCCAGGCAACTTGTCATAGAGTTCCTATGCCGCACACACAGCAGACATGACCAATCTATC


CCACCATCCTTCCTCAGTGAGCTTATGGGCCACTGCAGTGTGAGATGCCCAGCCTGGAGTGCCTGCAAACCATTTTTGGTCTCCACT


CCTTGAGGCTCTGTCCCAGTCATGACTTTGGTCTTTGGCGTTTCTTCACTTCCATCCCCTAACCTGGCTGCTCTGGCCATTCTTGGA


GCTATTTTACTACAGTCATTTTGTGTTGTGTTTCTGCCACATCCACAGCAGTATGGCAGTAGCCCCCAGCATCTTAAGTAAGTTACA


GGATATACTATTTTTCCATTATTAAAATTATTAATGATTCATTGATATTTTGAAGAGTTCATTAATCACGCTCATTCATGGTAACTA


TTAGCATGGTTTATTACTTTCAGCTGGGGTCTGTCTATCTTCCAGCCTGGTGATCTTGCCCTTGGGCTGCACTGGAGTCTTCTGACC


TTCCTGGTTGCTCCCCTGTGCCTCACCACTTCATCTCTTCTGTTTGCTATAAGGTGCAGTGAGGGCAGCTGGGGTAAACTTCTGTCT


GCCTCTTACAGGCATTTGGGCACCTGCCTGGCCAAAAAGCAAGGTGGGTGCTTCCTCTCTGGCTTTCTCCCGGGACGGAGGGGAGGA


GGCCACCAGCAGTTGTTCACCGCCCTGCTGCTTGAAGACTCTGACTTAGCATTCCTGGTTTGCATGTCTGACACCTCACTTGGCACA


TGATTTATTACAGTTTTAAATAGCCCTTTCTTTCTGGATTGAACTGTCCATATCCATTTGGAGTGGAAAGACCTGGCTTGTGGTGTT


GGTAGTGCAAAATGCTTTTCTGAGTGCGATTGTTTGGGGTTTTTTAGTGTAGCTGATGCTCTCAGACCAGAGTGCTGCTCCCTGTGT


CTGGCTGGAATCCAGGAGACAGAAGCAGACATTTGCCTGCCACCTGGATGAAGGAGGACATGGATGCAGAGAGCCTTTTGTTTCTTT


TCGTCTACATTTCAGAGACAGAGCATCCCAGGTGAGGGAAGCAAGTCTTATGAACAGCCTGGAGGGGGGTTCAGAATCCATCCGAGC


CATTCCCCTGCCTTTGTGGTGGGCTTTACCTCTAGGTCTAGGCTTTGTTAGGAAAACACTTCCCAGGGAGAAACTTTCCTTGGTTTC


TCTCTCTTTCTCTCCCTTCCTTCCTTGGGGTTTGGCAAGTCCTTCTAGGCAAATCCTTTTTGCCGTAGTTAGAGCACCTCAGGGATA


GTTAAACTGGAGTACAGGATGCTTACAACAAAACATGCAAATTCCCCTTCCCATTTCAGAGACATATGTCCCCTAGATGTCACCAGA


ATTAGCTCATCAGATTGTAATCACCATCCTGGGATTATGATGCTGTGGAAAGCAGCAGAAATCCTTTTGAAACCCTTTCTCCTCCAG


GGGGAGGGGGAGCCCTACCAGCTTCCTGCAGAACATTCTGGTTCCTTTTGTTATCCTGCATTTCTCGACTGAGATCCACTAACAGCC


CACATCCTCTGTGCTGCTGGTTGAAAGGCCATTTAGTGTGGTCCCAGTGAAAAGAGAGAATTTGGCATGGCTGTAAGAGCCTAGCAG


AGAGAGGAGCTGAGGGGACAAGCCACCTGGGAGCTGCATGAGTCTCAAAGGGAGGCCCACCAGCCACATCCAGACCCTTCATCCCTC


ATCAAGATGCCACAGTGAGGGCCACCAGCCCATTTCCACCTTAATTCCATTGGAAGCTATACTTCTCCCTGGAGATTCTGACCCCTC


CATGGCCATGAAGCAGAAACCACCCATCATGGTGGCTTGGGTTGTTTGTTTCTTCCAAGGGTTTCCTGGCTAGTTAGAAGGGTGATT


TTTTTCTTCAATATGGGATGAAAGAAAAAGACAAGATTTCTGAGGGTTGGAATCATCCAAGGAAGGAGAGTTAGTTCTCGAGGTAGG


TGTGTCTTCCCCTTCCAAATTCACACAAACAATTAAGAGGTTGCAAGAGTTCTCTGGAAAACTACAACCTACTCATTTGGCCACAAG


AGAACACAATAGTTAGTGTCCACATGCTTTAAGTACGATGTCTTTCTTGTTGGAGAGAGCTCTAGGTTATCAGTAAAATACACAGCT


CCACTTGAAAAGCTTTTTAAAAAAAGAAACCCAGCTGAGAGCCCCTTCCTCTTCCCGCTCACGAGCCCCCACTCCTGCCTCCTCCTC


CCCTTTTTCCCTGTTCTGCCCTGCTACATTGCTGCAACCAAACTTGGCACGGTTACTCAATCGCTAGTCTGAAGGGCTTTTAAAACA


CGTTCACAGACGTGCTCTTGATCCATTCAGTTGTCCAGGGCAGACCCTCGTGGAGCCCTACTATGTACCAGCTATAGAACAGACAGA


ACGACGGACTGTGGCTCCTGCCCTGCAAAAACTGTTAGCACCGAGCAGGAAGTCTTTCTTTTTCAAATTATGGAAAAATTCACATAT


TATAAAATTTACCATTTTGGTTTTTTCCTGAGACAAGGTTTCTTGTATTCCAGGCTGGTATCAAACTCTGTATGTTGCCTGGGAGGG


AAAGGGGGAAGTGGTGTAATTATAAAAGAGCCATCTTGGTGGGTTTAGTCAATCCCTTCCCCCCACCCCCCAACCCTTAATCCCTAG


ATTAAGTGTAGTTAAATCAAGGACCCAGAGATGGGAGCCAGTCCTGAGTTATCTGAGGGCTCTGCTGACCACAAAGTTTCTTGTAAA


CAGGGAGGCGGAGAGGCCTGACCCCAGAGGAAGATGTGAAGCCAGAGTCACAAGAGGTCCAAAAGACTGGGAGGGAAGGAGAGGGGG


CTGGAGAGGGCCAGGAAGTACAATTCCTCAGCCACCCTACACGACACCTGGACTTAGTGCAGAGTCATCATCTGATCTCCCGAACTA


TGAGACCACACATCTGTGATGCTGTGGTGTGTGGAGGCCGCAATAGGAATCTGACACATGGACATGCTGGAAAGGCCGGAGAGGCTG


GAGAGGCCGGAGAGGGGTCGATCCAGGCTAAGCTGCCGAGCAGCTGTGTGATTTAGTCTCCTCGTGCCTCAGCTTCCTCCTCTTTAA


AAATAACTGGGCTCCCACAGCGGTTTGTTAAGGGTATGGAGTTAATATTTGTAAGTCACCGAATGCCTGGAACCAACAAGTGTGCAT


TTGTCAGATAAATAAAGCCCAAAGCGCCCAGCCAGGTCTGCCTCGTAGGTCTCAGTGGGATGATCTCATAGCTGAGTCAGTGACTTG


AGTCTGGTCAACTGGGAGCTGGAGCCGGCCAGGGAGGATGGCAGCTTTTGGAGCCTGCTGCTACATCATTAAATCGGAGCACAGATG


CTTGAAGGGATGGCCCCTCTATTCCCCGTCACACCACACCAGGCCCAAGTACATCTGCGAGGCTGCATCTCAATGCTGACCAGTCTG


CTTCCCTTTGGGAACCACAGAACGAGACCAGTGGATTCTGGGAAAGTGCTTCAAACAGCCAGCACTGGCCCCTGGTTCCTGTGCTTC


TCCAAAGACCAGGGATCTCTGAGCCGGTCTGCAAGCCCTGGGTTGGTACAGAGAGCAAAAGAAGGCAGGACAGGCCAAGAGAAGGCA


TCATCACCATATGCCTGACCTTGGAAGGATCTAGAAGATATGGTTGTGGCTTCTACTGCTGCTATAATCCACCTCTTAGATGGTCAG


AGGCAGTTGTGACAGATCCATTTCTGACATTTGCAGGGCTTACAGGTCAGCCTCACATGGCAGCACCTAACATCACTTCAGTCGTCA


CACCCAAGCTCCGTCAGGCTCCCCACCCCCAGGTATGGGGAGCATCTCAGTACCATGTGGCCCCGGGGGGAAGGCTTGGCTCTTTGG


ATAGGAAATTCTGGGGTAACTGGATATCTGGACATGAGCTTTTGAGGCGGCCTGGCCCATGGGTTTCCAGCTCTGTGAGATGGGGCG


GGGCAGAACCCTCATGTGGCTTATAGATCAGGAGCCCTGGCATGTGGGTCCAGGGCAGTGGTGGTTATCAGTGCAGTGGTCAGGGCG


CTGGATGGTAACTAGCAGCACTCTCTCCTCTGCCCTGTCACCATCGCAGCCACCCCAGTCTGAGCCTCACTTCCAGCACAGGCTTCT


GTGAGACAGCTCTAAACCTGTCTCAGCGTGTGTGTGTGTGTGGGGGGGGGGGTGTCACTTGAACCCTACAAGAGGCCCAGGGACTCT


GTCTCCTTGGTGGTTTTGCCTCTGTGGCTTTCTTCAGACCCTCCCCTGGAGGGAAGGGGCAGTGGTAGGTGGCTGATGAGTCCAGCG


GTGAGGAAAGCACCTCCTTTGGAATAGGGAGCCAGCTTCCATGGTACTGGGCAGGCTGAACACGCTGTGGTAGCTTTCAGGACCTGT


AATGGGGTCGGCCTGAGAACAAGAACCTTGTTTAATTCTTATGCATAAGAAATCTTTTTCACAGGGTGGCTTAGTCCGGAGGAAGTC


ATGGAGCTTGCCTTGGAGCAGAACACTTTGGGGACCCCCAGGAGAGGCATTGTCCAGCAGTGTGGGGGGAGGCTGGAAGCTCTGCAG


AGAAAATAGCAGGGCGGGGGCACACTCAGAGGATCAATTTCCCTGCAAGAATGGCCAAGCTTAAAAATATCTTCAGTAGGCTCCAGG


AGTGGCTTTTCCCGGGAGAGTTCTACTAAAAAAACACCCCATTTTATTAACTTTTTAAAATTACAGAAACAATATTGGCTTGTTTTA


GTGCAGAGGTGTGTTCTAACTATTAAAGGTTAAAAAAAAAAACAATAGTTCCCTCGATTCCCGTTCTTACCTCCCCAGAGATGTAAG


ATGTCAACTATGTGATATTAGCCAGAGGTGGTCTGCGCACCTGTGTGCATATCTGTTCACACTTACCAGAAAACCAGGTCACCGTGT


ACACATACGGAGAGATGCTTGTCGGCATGCTGCCGATATTAAAAGGGGGACTCACACTATGCCTCACTGCATGGTCATTTTCACTGT


TTGCTTAGCAATACACTGTGAACCTTTGCTAAGTTAATACATATAGACCGGCTTCATTTTAACCAGCTGCATAATGTTCCATAGTGT


GAGCACCATGGTTAGTTAACTGGCTCCCTACGGATGTGTATTCGGGTCATTTTCCAGGTTAAAAAAAAGATGTTAAACAAGCAGCTC


TTTAGAGAATGCTATTTGATTTCTTTATTTTGGGCACGTCTTTATTCTCTTGCTTTGGGAGAGTTAGAGAGCTGGTGGTCTTGGGAG


TTCTTTTCTTTTCTTTTCAGTCACATTGACATAGGTGAGAACTTACTGCATCTAGATCCATCTGGAAAGCCCATACTTTCCTGAGCT


TGTGCTTGGCGCCCTGGCCACGTGGAAACCAGTCCTCAAGAGCACCGTGTCAGCCAGGGGCCGACAGGCAGCAGCAGGTCAGGTATC


CTTAGTTCAAGCAGGAGCTGCTCGCTTGGGAGCAAGCTGGAGAGCGGGGTTGTGGCTGGAAACAGGTGTTTATTAATGAGGGTGTGG


ACTCCATCTCTCTAACCTGAGGTCTTGGGAGACCCAGCTTAGCTGTGGGCTAGAGACCCAACAATGCTCTTCTCGTGGGGCCATTGC


GAGGAAAGAATGAGCGACTGCACCCCAAACTCTGTAGGACAAGAATAGACTCAAGCGATCTAGAGTACAACGGAGTGACCAGAGTAC


ACAATAATCTGTTGTGTATCCTATGAAGCTGTAGACATAGGGGTGTGTAAGAAATGGCAGAGGGACAGGGGAGATGGCTCAGCAGTA


AGACTACTGTTACTTTTCCAAGGGTCCTGAGCTTTGAATCCCAGCATCCACGTGGCAGCTCACAACTGTTTATAACTGCAGTCCCAT


GGAATCCAATGCTCTCTTCTGGACTGCAATGCAAGCAGTCAAAACGCCCATATATAAATAAATAAATCTTAAAGAATTGGTAGAGAT


AAAAAGCTAAGCCCCTCTATTGGCTCAACACACATGTATTAAAGTATCACATACTGTGCCCCATAAACATGCAGTTACTACATGTTA


ACCAGAAAGAGACAAAGAACCATCACTCCATCAGAACTGTGCAAATGGAGTAAACAAGTGGCCAGGTGCTCCCTGGGAGAGCAGTGA


GTGCTCCCTGAGGGCTAGTACTTCAGAGAGTCCTTTTTCATTTGTTTACTTTTAATTTTTAAGAATTACATATAAATGTGTTTATTT


AGCTACTCATGTGTGTGTACATATGGGCATGTACATACCACAGTGAATGTATAGAAATCATAGAGCAACTTCCAGCTGCTGGCTCTC


CCCTTCCATCCCTGTGGGTTCTGGGGGTTGTATTTAGGTCATCCATCAGACAGGCATCTTCACCCACTGAGCTGTCTCACTGCTTCT


TGCTGTCTGTCTATCTGTCTATCTGTCTATCTATCTATCTATCTATCTATCTATCTATCTATCCATCTATCTATCAATCGCAGGGTC


TCACGTGGCCTATGCTGACCCTGTACTGCCTCGTGCCTTTATTTAATTTGGGCAGGCTCTCGGGTAGTTCAAGCTGGCCTTGGACTC


CCAGGATAGCTGAGGATGACCTTGAACTCTCGATCTTCTTGTGTCCACCTCCCAAGGGCTGAAATCATAGGTGTTGCTCCTACATCT


GGTTTCTTTTTGTTTTTTTCTGAGACAGGATCCTCTCTGTCATTCAGGATGGCCTTGAAGTAGCTGCCCGGTGCTGGCATTGCTAGC


CAAGGCCTCCGCAGCTGGTCCTGGACAGTGAGTTGAAGAGCCCTTTAGTCGGCCCATGACACACCAGCTCTCAGATCCCAAGGGTGC


TCAGTGATTCCAAACCTCTTGACCCGAGTTGTTGAAAACACCCTTTAAGCCATGGCTGAAGAATCTCCAAACAGTAAATAGGATGGG


TTACTGGCCTGGTGGCCGGTGCTCAAATCGTTAACCCACTCCCCATCCTAATCTTCCCAAAGATACTTTCCTGTGTTAAGCTAAAAC


GAAAACTTAAGAAACTTCCTGTTTGGAAAACCATTCTACTTACCCCAGGCATTACAGGTGCCAGAAGCTGCCACTATCAAGGTAGAA


AGAATTGGAAACACAACACCAGCTTGGTCCATGATAGGCAAACACCAGATCACCAACCCCCCAGCATAGCCTGGGCTGGGCTGCAGT


GGTCAAGAACATAGACGTACAACAGAGTAGATTTTAAAAGAGTCAAAACCTGCCCTTCCTTAACTATATGACCATTATTAAGTTCCC


ACAATTTTCTGAGCCTCAATTTTCCATCTGTACAATGGGACTAACCACACTTTTGGAACCCTGTTCAGGACTGAATGAGATGGTGCT


GTAATGCGCAGTTTATAGGGAATGGCATTGAGAGAGCACTGTTGCTATTGAAGGGGGTAGCTTGGAATTGGGGGGTGGCTGGCACTG


CTAACTTCTGGCCATTCTTTCCCAGCCTCTGTGAGCTGGGGACCAGTACTGGGAAGACCCTGGGAAAGGTGTGAAGATGAGTGGAAC


TGGAGAGATGGATCAGTCCTTCAGGGTGCTCTCCCGGGAGAAGCAGGAGAGTGGCACAGTAGTTGCTAACACCCCACGGGACCCAGC


TTGCCATCTGACTGTGGTGCTGGGTGCACTGTGGCTGATGACGAGGAGGGAGGTTCAGCTGAGAGCAGGTGGGAAGAGCTCTTTTTT


TCCAAGTGAGCTAAGTGGTTGAACTTGACCCAGAACCCCCTGGCGGACAACTGGCAGGGTCCAGTGAGAGAAGTTATGTGGCTTGGT


TCTGTTTGGGAACACTTGGCACTGGAAGGTGGCTGGAATGGGGCACTTGCTAAATCTAGGGCGTGGCCACTGTAACCAAGTCTGGTT


GAGTCACTGTGGCCTTACTGCATTGAAAAGAACTTGACAAACTCCAAACCTACCTGAGGAAGAAGGCCTAGTGTCTGCAGAAGTCTC


GGGGAGGGAGGCTTATTGGAAACTTCCAGAGCCAGTCTCGTGTTTCTGCGGAGTTCACGCCTATCAGGCACCAGGTCGTCTCCATTC


CCTCCCTTCTCTCCATAGGCTGAGCTGTCCTGGATGCCGGGTAGGACGCCATTGTCTGCTCCCAGACTTCTCTATTTCCTTCTCCGG


TCTATTTTCACCGCAGCAGGCATCACGTAGGGAATCCCATGGTGCATGTTTACTTGTTTCCCCACAGCGCATGCTCCGTGGCCCAGG


CTCCACTTGTTTTCTGGTTCTTGGAGTTTAGTCCACAGTCAGAACCCAACATGGTGGATAGATGGGTGGACCCATGAGCCCTTAGAG


TAAAGCTCCATGCCTGTGCATCCAGCAACATAACATTTTCTTTTTGTAATTTTTAATGGATTTGGCTGTTTTGCCAGCATGTACATC


CGTGCTGGAAGTGGGTGTAATGCCCATGAAGGCCAGAAGAGGGCACTGAATCACTTGGAACTGAAGCTTCAGAAGGCTGTGGGCCAC


TACAGGGGCGCTGGGAATCAATTCTGAGTCTCGTATAAGCACAGCATCTCTGAGCATCTCTCAGGCCGTGCATTCAGGAGCGTTTGA


ACGTGACCTCTCGTTCTAACATCAAACCTTGTCTTTAACCACAGCCAGGGGAAATCAACAGTTTCCCTGCTAAACCGGTGGGGCACG


GAGGTCGTACAGAGATCTGTGTAGGTGGAGGGGAGTGTGTTGGCACTGAACAATGTTCTCCACCCTTTAGCCTAGAAAGCTGAGTTT


CGTTCTCATATTGACCTCACATTAAAAAAAACAATTCATTAGTAGGAAATGGAACGCTGCAAACTGGATCCAACCCTTGTGTTCCAG


ATGAGGAGTCTGAGGGCCAGGGAACTGAGAAGCACTTGCCAGCAACAGAGCGCTCTGTCCCCATTGGCCCTGCTCAGGGATAGACTC


TTGCTGTGTGACTAAAACCTTCTCACATGCTGTAGCTTGACTTTCATGCTCCAAGAACTGGGGATGGTCACAATGATTTATGGTCAT


CACTGGCTTCCATTAGCCCCATGTGAACTTCAGACGCCAAAGTCCCAGAGGGTTCTCATGTCTACAGCAATAGACTAGAGAGTTCTC


AGGGGCACTTAGGAGGACCTTGGTCTGGCTGGCCCAAAGCCGCCATGGGACATCACACATGGCCCAGTGCCACCAGCCACAGGAAGT


TAGTTTCAGGTGGGGAGGATTTCTTCTTAGAAAGATGCAGGGCAGGAGAGCAGCACTCACCGTGCTCCGGCCTTGCTGTTGCCGCAT


GATGGCTTTTCTGACAAGGCCAAACAACGTGGGTTTTTGGTTTTGTTTTGTTTTGTGTTTTGAAATTTTGTTTGTTTGTTTTTTTGG


GGGGGGGGGTCTTGGGTTTTGTTTTTGTTTTTTGTTTTTTTTTTTTGCTTTTTGCTTTTTAAAAAAATTTAGTTATTTTAATTTCAC


GTGTATTGGTGTTTTGTCTGCATGTTTTTCTGTGTGAGGATGTTGGATTCCTTGGAGCTTTGCCATCTGAGTGCTGGTAATTGGACC


TGGGGCCTCTGGAAGAACAGCCAGCACTCTTAACCTCTGAGCCATTTCCCTAGCCCAACTTTTGCTTTTCAATTTTAATTTTTCTTC


GTCCCTTTCCTCATTTAGCTCCATGTGGCTTCTGCTTACTGGAAATTTTATGTTCATGGCTGCTGTAGACCTGAAGTTCATCTCATC


ACCGACAATCAGATTTTGTCCTCAGGGAAACCCAATTAGGGATCACAGGACTTTTTGATGTTGTTTCCATGGTAACCCCATCGTGAT


GGTGCACATACATAATATATAGTCTAAGGAGTTTATGTTTATTTATCTAAAAGCTATATATTAATAACACATTTTAAGAAAATTTTG


ATTTTTAAAATCTGAAATGTTATCTTCTGCATTAAAACATCATTCATTTATTTTTAACTTTGTGTGCATTGGTGTTTTGCCTGAATG


TATGTCAGTGTGAGGATTTTGGATCCCCTGCAACTAGAGTTACAGACAGTGGTGAACTGTCAGGTGGGTGTCGGAAATTGAACCCAG


GTCCTCTGGAAGAACAGTCAATACTTTTTTTTTTTAACTGCTGAGCCATATCTATAGCCCCTTCTTCTGCTTTTTTTTTTTTTTAAA


TGATGGAAAAATCCCCTGAGGGTTTTTCTCCCACAGAGGGAACATAAAAGTTCCCCTCCCCCGTCTCTTCATTTTTCTCTCTTTAAT


TTAGAAAATTTTATAGTTGAGTAAGAATGAACGCTTTTCATTTGGCTGGAATCTGTCTACACATTGTCTCCCTTGATGGCTGAGAAC


GTTTTATGAGACAATTTTGCTCAGATAAAGAGCAGAAGGGCCCAAGTCTTTCAAATGGAAGGGAACTACTGATCTAATGAGACAATT


CAGACACACTGCGACAGACAGGACAGTTAAGGCCTCGCCTGCTTCCTTGCCAGGGCAGCCACTCCCCAGCCTGCAGCTGTCCCACAG


GAGGCTCCAGGGTGTCTGGGTGAACTGACCTGTTCTGAGGTGACCAGATGGCCCTTCAGAGCTGGCTGTCACGAGCCAATGATGATA


GAGCTTCTCTGAGAGACTCTGTGTGGAGGAAGTAAGTCGCACCCTAGTGAGCTGGAGGGGCCAGGGGCTCCTCTGAGCTTAGCCTGT


GGAGAGCAGGCATCTGGGGCAAGCTCAACGCTCGCTCGCACACCGTGTGCTTTCTGAGATCATTTTCTTTGGTACCATCAGTGGCTA


CTCAGAGTTCGGATACTCGCAATGGATACCTTCGCCCCTGCCAGCTAATCCCGGAACTCCCTAGATCTGCTAAGGAGACGAGCTGAT


CTGGCACTCCATAAATTCTGCTCACCAGTGAACTTCCTTAAACACTTCCAGAAAATGCTTTAAAATAACGGAACAGGTCAGAAAAAT


AACTCTTTAACACTTTATTTCTTGGTGTCTGAAATGAAGTTTCCGTAAGGTGGCAGAAGGAGGGATGGCTATGATCTTGGCCCGCAC


TCCCCTGGACCGGCCAGCCCTATAACTACAGGGGTTAGAGAGTGTCAATAGGTATTGTGGGCTCTTTCTAGAGCTCACTGCAGGAGT


ACTGAAAAGGGAAGTGTCAGGTGTGGAAGGCCAATCACCTACCTGTCCTAATATCTATAGGCACACATCAGTATAAGTATATGTTGA


TGTGGTATTGTATAGCAATGCCCCTGAAAGACAATAGCTTAAGAGTACATCTGTGTAACTGGGCTCAGTGTGGTGGTCCTGTGCAGA


GCTTGGTCATGTGCTGGTCTAGGAAGGCCTTGCTGTCCCCCCTGACAAAGTTAGGTGAAAGAGAAAACGAGGCCATATATCTCCAGC


AAGCCCCATAGAACTGATCTTCTAAATGTCAGATGCATCGAATTTTATAACATCCCATTTCCCAAAGAAAGGCACTCGGTCAGGTTA


AACTCAAGATGTTGAACTATAGGCTATGCCTCTTGCAGGACGAAGAGGCAATGCCATACTCACAGTAGCAAGTGGCTCTGTGGACAT


TTTCTGTAATCGACATCTGGTACTTGTCTCCAAGCAGTGCTGAAATCCCAAGTTCTCCTTTGAGGGTCCTCATGTGCCTCTCTGATG


CTAGAGCCACTTGAGACTGCAAACTGGCACCCGGGACATGTGTTATGTCCCTACAATGGCCTAAGCTGGTTGTTTCTCGCTGGTTGT


TTCACTGAATTGAGCTGAGTTGAACTGAATTACTTCTGGCTTGACTCTAATTACTGCACATTAGGAATCACTCTGTTGTGTCAACCA


GCCTCCAGAAGCTCTTGGGATTGCAGTAACTCCCGCTCACAGGAATAAGAGAGGTAGTAGAAGGCTCCAGCCCCGAGCAACCTCCCA


CCATCCGAGGAAGGAGTAGAGTTTTGGGAAGTCCACTGGCTGTGGTGCCACATGTCCCTTCTGCAGACTGACCTCCCCCACCCCTGG


AATGGGGAAAATAGCTTTTCCAGTGTGAGGCAGCACAATTCAGCAATTTAGAGACAGAGTTTCTTTTCCTACCCAAGGAGTCAGTGG


ACGGAGCAGGAATGGAGGCCAAGCCCAGGCAGGGCCAGGAGAGAACTTCCTTGTCTCTGACATCTCTCCCTTCCAGGGCTGTCTGCA


GCTCTGCTCTTGCCGCCTGTCAGCATCACCCAGGGCCTTTCCAAAACCCACCAGAGGCAGTCAGGCTGAGCCATTGAGATCAAGCCC


CGGGGGTGACTGGTTCCTGGTGGAGACAAGGTGATTGGTTCCTTGCCCATTCCCCCCAGATCACTCTGATCCAGCACCACTCGAGAT


TCTGACTCCAGAACCAGCAAGATGTTCAATAGGCAAAGGTGCTCAGCCGCAAGCCTGATGACCGTGCATTCAATCCCCAGAACTCAT


GGTGGGATGGAAGAACCAGGTCTAGCAAATCGTCCTCTGGCTCTCCACACAGGCACGTCTGCATCTCCACAAACGAACGAACAAACA


TAATAAATATAATAATAGACGTCACTTTGAGAAATAATACTAGCTGCCTGTTCCAGGTTAGCTCTGGAACTTTCTGATGTTGGAGAT


CACCTGGGGCAGTTTGTTGCAGAGTGGGCCATCCTCTGGGAAGGGGGCAGCATCCTCCAAGGTGCAAGATGTATTGCCAGGCCCTTT


GGCAGCCATAGGCCTAGGGATGAATTTCCTGCAGGAGTTGTCACTCATTCAACAGAAGCTGACTTAGTGCCACAGTGTGCCAGCAAT


GCTGTAAGCCAAGCGAGCCAGTATGGGTTCTGCTCTAAGGAGCTCACAGAACACACGCTAGGTAGGAGGCGCCGGCTGAAAAGTGCC


ACCGAATTCTGGCTCCTTAGAGCAGGATGCATGTGCCAGTTAGGTTCCCCCATCCCCAGCTTGACATAAGCTAGAGTCAACTGGAAA


AAGGGTGCCTCAGTTTTAGAAATGCCTCCATTCCTTGATTAATGACTGACGTGACAGAGTGGGTGAGGCCACCCCTGGGCCAGTCGT


CCTAACAAAAATCAGGCTGAGGGAGCCTGGGAGGAAGCCAGTAAGCAGCATTCCTTCCTCCATGGCCTCTGCGTCAGCTTCTGCTTC


GGCTCCTCCTAATGTAATGATAGTCGGTAATCTGTAAGCCAAATAAGCCCTTTTCTCTCCAGGCTGCTCCTGGTCCTGGCATTTTAT


CACAGAGACCGAAACCTAAGACAGTGCACACTGGGGACCATCATGAAATCTTTATCTTCAGAGGAGGAAACTGCCCAAGAGAGGGAA


GATTAGCTGCCCAAAGTCACATAAGTGGTAGCATTTAATAAACATCTACTACTTGCTAAGATTGAGCTTAAGCATTGGCAATAGTAG


AGATCAAAGAGAAGCTCCCACTGAAATCACTGGGTCCCAGCCCTGGTTATCCTTTGGTATCCAGGAGCTGTAAGAACAATCCAAGGC


TGGGCAGTGGTGGCGCACACCTTTAATCCCAGCACTTGGGAGGCAGAGGCAGGCGGATTTCTGAGTTCGAGGCCAGCCTGGTCTACA


GAGTGAGTTCCAGGACAGCCAGGGCTACAGAGAGAAAACCTGTCTCAGAGCAAAAAGACAGAGAGAGAGAGAGAGAGAGAGAGAGAG


AGAGAGAGAGAGAAGGAGGAGGAGGAGGAGGAGGAGGAGGAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAGGAAGAGGAAGAGGAAG


AGGAAGAGGAAGAGGAAGAAGAAGAAGAAAGAAAAAGAGAATAACTCCAGGACCCAGGATGCTGAGGCAGGGAGATTGTAAGTTCAG


AGGCAACCTGGGCTAGATAACAGATGCTATATCAGAAAATAAGTACGAACACTCCAATGTCAGCCCCTCCCTGACCCACCTCCCACA


GGTTCTTGGTCTGAGAATGGACCTTGGCAGAGGGATGCTTTTCTTTCCCTTCCCCCTTCCTTCTTTCCCCTCCCTCCCCTTTCTTCT


GCTAAGCCCCTGTTGTGCAAGGCAAAGGGATTTTAACAGGCCTCCAAAGTGGCTCTGATGTGCAGCCACTTTGACAGCCATTGGTCT


AAGTGACAAGACGGACAGAAATGCAGAAAAGGCCAATAAATAACTGAAACTTGTGATTGGCAAGGAATGAGCAGGAGGCAGAGGAGC


TGCAGGGTGATCTGCAGGAAGCGAGGTCACACCACAAAGCTGTGATTCCAGGGGTAGAAGGCACAACGCTGTCCTGTATAGGAGAGC


CGTGGATGTTCTGGGAGATGCCCGGCTCTACAGAGCCATCAAACCCTGTCATGATGCCTGTTTAGTAGGTACTCTCTGTCTGCAGCC


TGAAATAGTTCTCCTTGTTCCTCTACTCCAAACAACCTCCTCCCCCAAGTACACACTGCTTATAAATGCTCTAGCAGCAATCTCTGT


GATCCACCTAGAGACTAGTCAGTGGAGTGCCCAGGAGCAGGTGTCCCATAATGGAGACAGTCGAGCAGACTCTGAGGTCTAACACCT


GATGTGGGAGGTTCCAGCCAGCTCACCAGCTTCTGACTTACTACGCCCATCTTCCTTGCATCAAGAAACTGAGAGGCCAGTGGGGAC


AGCACCCCAGGCCAGTTCTTTCCTGTTGAGCTGTGTAGCTCAGTGGGGAGACCCCATCCTTCCGTTTAGATGATGTATCAGCTCAGT


CTCCACCAAGCAATCAAAGGAATCCGTTACTCATTGCTTCAGTTCCTACTGCATGAACCCAGTTACTATAGCAACTGAATGTGCTTC


TTTATTACTGGATGGAAGGCTTTAATTTTGTATTTAAAGAGTTTGGCCAGAGAGTCATGTTGCCATGACTCGGGCTGTTGGATAGCA


GTTAGGAGCAGACAGACACCTTGGAAATGGCCATAGATCTGTCTTTCTAATTGACAGATCGGGGCCTGGGAAAACCTAGGCTGCACT


GCCCTGAGAAGTCTCCCCTGGTGCTGCGCTGGTACCTTCCCCTGTCCACGGATGGTTCCTGATGAGCAGAGGCCCCTGAGCCAGGCA


TTCCCATGGTGGCCTCTGCTTTCCCTACTGAGCTTCACCCAGGGGCCTTGCTTGGATGTTTTTGCTTTACCCTCTCCCTACAGGCGG


CAGGCCTCTAATGTGTTTGCTGAATACTGGTTTATGACTTCATTGAGTTTCACATTGGTTATGGCCCTGTATGGTCTCAGGACAGGA


AGAGGGGAAGCTGAGGCTCAGTGAGGTTAGAGTCTGGCCCACCCCACAGCCTCCCCTTTTGCCTCTCAGTGGGCTGCTAGGATGTCT


GGAACTTGATCCCACAGCACACAGATGTCACAGGCAGACACTAAAAGCAAGAAAGGCCATCTCCACACAGCCCTCCACGGCACACAT


GTGCTGTCTACCTCATGTGACTCACCTGTTTGCCTTCTATTTGTATCTCGTGTGCCAGCGACTCTTTGACTCTCAGGTTTTAGAGTC


TTCTCCTTGGATGAAGGGGCTCATGGGAAGGCAGTGGAAAGGGGTTAGGGGGATGCTCAGTGACTGCCTTCGAAGCAGAAGGGTAGG


GTCCAGACCTTGGAGGACACAGAGGTAGTCCACTGCAGGCAGAAGTGGGCGGAGCAGGAGCCTTAGTTCATGTAATCTGTGACCAGC


CCTCAACTCCCCACACAGCTGTCTTTTCTCCTCTGTGAATGCTGGATTTGTGGTTAAGCTCATCTTTCCCCAGCTTCTACAACATCA


TCGGCTTCTTTCTCTCCCATCCTGACTTTTCACTGGCCTTTCAGAACTGGTCCCAGGCAAGATTCAGAGGTCACTCTCCCTTCATGA


TGTGCAAGTGGGAATGCCTGTCCTCCAAGGCTCACTGCCCCCAAACACCAACCAAGTTAGGCCATAAGACCTCCACCCTACGTCTTC


TCTAAAGGCTAGAAGAAGCCATGTTGGAGGGCAGTAGTTCCCTGGGGACCTGGGCAGAACACATGGGGTGCATGGCAGCAGATGGCA


TCCAGGGAGATGGATGTATACAAGCAGCCTCTGTAGAGGGTATAGCGAACACCACCATTGTCCTGGCTATAGCTCCAGCCTTATGCA


GGCCCCAGTTGCTTGGGACAGAGTTGCTGTCAACAGAGAAGACCAAGCTTGTTGAAAGGCCAAAGTGGAGTTCCTGAACAGAACACA


GAGGAATCCCATAGTAGGGCTTCCACAGAGACAAAGCCTGGGCCTCCCTCAAGATGTGAATCTCAGCTGAGTATGCACAAGGCAGTA


GTAGACACCCAGGGAATGTCTGCTGGAGTGCATCCTCATGACATGGCCCCAGGATTCGCGGCTCTGAGGAAGACTGGGGTTAGAAAG


AAATGGAGACAGCCGAACCCGGCCCTCATTGTATGGAAAGAACAAGATACGGCTAAAAAGAAGGCATAGCTAATATTAACAATAGCT


AATAGTGACTGCTTTGCTCATGGGGGGTGCATGGCGGGTTTGTTGAAGATCAGATATACTATTGTATATGATAGATGCAGTGCACCC


GTTGTAGCCTCTGCAGCAGATGGCTCATCCCCAGGCAAGAGGATGGAGAGGCAGAGAGGTTCAGTTACTCACCCAGGGTTCCAGCCA


GACCTGGCTAACAGTAGGCTCAGGAGCCATGCAATGAATGCTCCATGCATTACCCAAGAGTGCAGAGTGGCCTGCAGACACTTGCTG


CCCCTTCTGAGCTGGGGTCAGGAACCTGGCTGCCCTGTAAGCTCACTGCTACAGGAAACATCCCTTTCCCCCATGCCAGGCCTGCTG


AGACTCAGGGGTGTGGGGTTTGCTTGCTTTTGTTTCTCCTTTAAATACAAAAGCACTCTTAATCCTCCTTAGCACAGAGTAACACAT


GGAGGCTGGATCCTTCATGCTGGAAGGGACTTGGCAGTGGAGAGCAGAAAGAGACGGACCCAGCAGCTCTCCTCATTCCCTCTGCTC


ATTGGATTTTGGGGAGTGCTAATAATGTATTTATTGTCATTTTATGTGCACTGGTGGTTTGCCTGCATGCATGTCTGTGTGAGGTGT


CAGATCTTGCAATTGTAGATGGTTGTGAGATGGCACGTGGGTGCTGGGGTTTGACCCTGGGTCCTCTGGAAGAACAGTCATTGTCCT


CAATTGCTGAGCCATCCAACTCCGATTTGTGGGAGTTCGGTCCACATGCCAAACAAGAACAACAAGGGGGTGTTCTGCAGTTTAACC


CAGCTTTAACACTCTACTTGAAGCTACATTAAATGCCACTGGCTACTGGCCTGGTCCTTCAGCTCTGTCCCACTTCAAAAGTCCACA


CGGGGCTGACTGAGCTGTGAGTCCAGGCTCCCATGACCCTGGGCCTTGGATTTGAGTCACCTGATGGAATCGAGTGCACAGTTCAGG


GAAACATTTGCACAGTTATTCTTCGGGGTGTTTCAGAGAGTCCTGGTGAGCAGCAGCCTAGAGTGGACTCCAAGGGCAGGAGTTCGA


GAAGGGTATGAAGCTGCCGGGGAGCCTGTGGGGGTGTTACCTCCCAGGTGCCTCCATGTGGTCAGCTATGTAGAAGTCTCCAAACTT


GGTCCTTGGGCTTGGCAGAGGCTTCTTTGTGTAGCACACTTGATGAAAGCGTTTGCCACTGATGGTCAGCTGCTAGGGAGGGTGGGG


TTGGTAGTCTTTCTCCTCCTTGCTCCCATCCCAAGGCTGGCCAGTCAGGATGTGGGCGTTCGAAAGACTCTGACCCTGACTGTGCTG


GAGATGTGACTCAGTGGCAAAAACACCAGCCCGGCATTTAGGAGACCCTGGGCTTAAACGCTAAGTAACAGTAGGCAGCTGTGCACA


CCTTTAACCCCAGCACTTAGGAGGAGAAGCAAGTAGACCTCTGCGAGTTCAAGGTGAGTCTAGTCTACAAAACACAGGCCTGCCAGG


ACTACATAGTGAAACCCTGTCTCAAAACAAAACAAGCTCCAAAGACTCATCATTTTTGAAGCTCACTGTGTGTGTGTTATGTATATG


TGTGTATGTACATATGCGTGTGTATTTGTGTATGGGGCCTGGGTATATATGTATGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT


GTGTGTGTGTGTGCCTGTGCACATGTGTGTGTATTGCTGGGGGTTAAACCCCAGTGTCTTGTACATACTCTGCTATACTCCAGTCCT


CTCCTGGGTTTTAGTAGTTGCATTCTTCAGCCAAGGTGAGGACCAAATGTATTATTTCTTATTATGAATGTATTATTATCCAACTTG


TCATGATAGCCTGTTCTTGCAATCCCAGAACTGGAAAGGTTGAGGCAGGTGGATTTCCATGAGTTTGAGGCTCGCTGGTTACAGAGT


GAGACCTTGTCACAAACAAACATATCTTAGGAAGCAACTTCCAGAGGAGGGAAGTGAGGTTCAGAGAGTGGGTGTCTTAGCTAAGAC


CTCCATCTGGATCCAAGCAGGTCTTTTGACTCCGCTGGGACTCTCACACAGGTAGGCTCCTAGCCTGCCCCTGAGGTGGTCAGGCTC


TTGGACCCCCAGCACCCCCACCCTGCCTCTTGTGTGACACTCCTGCTCACCTGTCCTGGCCACACTAATGTGCTCTTCACTCCTCCA


GCTCTTTGTGATCGACAATGGTGCAGATGACTGGCGGATAGCCATGACCTACGAGCGTATCCTCTACATCAGCCTGGAGATGCTGGT


GTGCGCCATCCACCCCATCCCTGGAGAGTACAAGTTCTTCTGGACTGCACGCCTGGCCTTCTCCTATACCCCATCTCGGGCAGAGGC


TGACGTGGACATTATTCTGTCCATCCCCATGTTCCTGCGCCTGTACCTGATCGCCCGGGTCATGCTGCTCCATAGCAAACTCTTCAC


TGATGCCTCCTCCCGAAGCATCGGGGCCCTCAACAAGATCAACTTCAACACCCGATTCGTCATGAAGACGCTCATGACCATCTGCCC


TGGCACGGTGCTGCTGGTGTTCAGCATCTCTCTGTGGATCATCGCTGCCTGGACTGTGCGAGTCTGTGAAAGGTATTTCAGGGAGAC


CCTGAGCGTGGGATGGGGGAGGGACAAGGAGCAGGGATGTCCAGGTCTAAGGTCTGATGGAGGAGGCTGGAATGGTCTCAGATTCCT


CAAAGGAGAAAATGAGAACAAGAAGAGGAGGGCAGAGCTGGTGTAGAATATTGGAACATTGGAGCCCAGGTAAGCTGGGAAAAACAT


ATATAACTAACGTTTGTTTCTTCTTTTAGACCAAAGTGTCACACCTCCCCCTTTTATAATATTTATTTATTTATTCATTTATTTAAT


GTATATGAGTACACCGTATTCTTCAGACACACCAGAAGAGGCCATCAGATTCCATTATAGATGGTTGTGAGCCACCATGTGGTTGCT


GGGAATTGAACTCCGGACCTCTGGAAGAACAATCAGCCCTCTTAACCATTGGGTCATCTCTCTAGCACCCTGGTTACATCTTTAACC


ACAGTATTTATTGATTGACAAGGTTTTGAATGTTCTCCTCTTAGAGATTAATGATGCTTGCAAATGTGTATAGGGCTTGGAAAAGCC


CTGCAGTGATGAAGCCTATTTGTTTTTGCTTAGTTCAAATTTCCTCATATAATTAATTTTTGCCCACAGATCTTTTATTTTTAATCA


CACACCTCTAGTGATATGTCTCTGCTCAAGGTTTGGTCCACTGATTGACAGCATCAGCATCACCGGGAGACTTGTTAGAGCACAGAG


CTTAGCCCCAGAGTTACTGAAGCAGCAGTGGCCTTTTAGCAGTGTCCTGCTTTGATTCATGTGCACTTTAAAGTTGGAGAATCACTA


TGGTGGTGAGACAGACTGAGGCTTTATGAGGCTGGGCGGTGATTCGGAGGTCTGCAGATGGGAGTGGACGGAGGGACTGTGGTCTCC


CAGAGACCCAGGGCTCTGCCATGACCTGACAGCTCTCAGAACATCCACCCTTGTGGCTCCCCATTAGGATGATACCACCACTCCGCT


GTACCCCTCAGGCCCTGTTGGTGACACCTGTCCCTTTCAAGCTGACCGTGTCTCGTTCTAATCAGATTTCCTGTGTAGCGTCTGCCC


GAGAAGCCGTGGTTTCAAATTGAGTGTCACCTGAATTAGAATAAGGCCATGGTCCCGAGATAGAGCGCTTTGGTGTGGGAAGGCACT


GAGGAAAATCCATGCTGCTTACACAGGTCCTGGTAGCTGTCCTTAGTGCATCAGCACTTGCGATTTGACTGTCAGATCTCCCACATG


CCCATCTCTGAGCTGAGATAAAACAAGGCAGAGAATTCAAGCAGACAGCTGGCTGAATAGTTAGCACATGGGAGCCACGAATGAGAT


TTCCCACTGGCTTTGGGATATTCAGCCAGTAGGTATGGCTTTCTGATTTCAGACAGAGGCATTGTTCTGCCCAGAACATGGTCCTTA


TATGAGAGGAGCAGCCTCTGAGAACCAAGCTGTTCTCTCTGGGGAACAGAGAGCCCTAAGCGACACCACCCAGAGCCCTACCATATC


TCAGCAGCTAAGTTTCTCTTCCAAGCAGGAATCCTTACCAAACAGCTCTTCACAAACCTTTCCTATGACAGAGAAATGGTGCTCTGC


TTCCTACCCACAACTCCTCACGGAACCATCTTGCTCGTTATTTGAGACAGGGTAGAACTTGTGACCCCTCGGTCCTATTTCCTGCCT


CACTATGCTGGGATGGCAGGTGTGCACTACCACGCTGGCTGCCTCATGGGACTCTCTGCTGAGGAATACCAGTCACTCTGCCTTCCT


GGGATTCAATGATGAATGAAGAATAATAATTCCTGCTTTATAGGATTCATTGTTAGAGCCAAGCAAAGCAATCCTTGCAAACTGTAC


CTTCCCACACATTGTGTAATCCCCGGGTAACTCGGGATCTTTGTGGCTGCCTTTTTTAAATAACCAGGATAGACAGACTGCTACCAA


ATGCCCACTGATACTCATCCTATTTTCCTTTCTAATCATCAGAAGCCAGGCTTTCCAACAGTGGTGATTCCATTTGTATAGCCCTTT


GGGGCACTTGAGGTTTTTCTTTTGAAATACATGTATTTCATGAATACTTGTCTGGCATGTATTTCAGATGAATAGGCTGGTTAAACA


TACAACCAGGTACCTACAAGTGAGTTTTATTGTTTATTAAAACTGTCACAAGTGTGGTGGCTTATTTATTCATTTCTGAAGAATAGC


CACATTTTGAAGGGCCTTGTTTACAGAAGTCTTTGGATCTTAGTTGACATTGAACTCCCTTCAAAGCTCCCAAGTTCAGGCTGGACT


TGTCTGGTTAGATGAAGTTAGTTTGCATTAGGCTGCAGTAGATTGTGTTAGTCTCCATTAGCCCAGGTTAGACAAGACTAGCCCTTG


TTAAACTAGGTTTGCCTGTGCTGTCACAGAAGCCCCCACAGTTACTCTTGTTGCAAACATGGCTTCTGAGCGTCAGTTGAACATCGG


GAAACCAAGCAAGCCAGAGCCTCCCATAGTCTGCCCTCTAGGGAACAGACTTTGTGATCACAGGCTCAGAGGTGGCTTAGGCATATG


TGGTGCTGAGCACAGGAACACATCCTGCTACTGCTTCTCACTCTGTGCTGGTTTTGTATCACGTGCTTCATGCTATCCCAGCCTAAC


CCAGCGGCAGACTCAAGGAAGCCAGTCTGTCCTCACCTTAGGGCTGGCTGCTGGAGAGAGCGTGGTTTGAGGTCTCAGGGCTCCTAA


GTGCACAGTCAGGGCGTAAGCATGAGTTCAATTCCAAACTTCAAATTTACCTTGTCAACCCAGGCTGGATCCTGCAGCGACAGGAAA


TTGTGCTCTAGACTGCCCTAGACACATCCCCACTCTGAGGTCTGAGGGTTACTGTGGTGACACAAAAATGCCAGGCTTGTCCTTTGG


TCTTCTCAGATGTCTGTGTCCTTGATCGCTTTGTCATGCCGTTTCCAGGGCTGTCTTTATGCTCAGTGAAGTCTTCATGTGTGTGCA


CATGCGTTTTTGTTTGTTCATGTGTGTATGTGCCTGTGTACATGTGTGGGTGTGCATGCACGTTTGTGTGTGTATGTGTATTTAAGT


GGATAGAGTGCACCCACTCTGCCCTGTGTTGATTTGAACACCAATCACTTCCACCTGGTATTGCGCTGGCTGTGAAACGCCACCTCT


CAAGGGAGCTGCCTGACTCAGGGGTGGCAGGGAGCCACTGATAGGGTATAAAGTAGAATTTAAAGGCCCCTTTACCTCCTAGAGCAG


TGGTTCTCACCTTATGGGGTTTGAATGACCCTTTCAGAGGTCTGCCTAAGACCATCTGCATGTCAGATATTTACATTATAATTCATA


ACAGTAGTAAAATTACAATTATGAAGCAGCAATAGAATAATTTTGTGGTTGGAGTCACCACATGAGGAGCTCTATTAAAAGGTCTCA


GCATTAGGAAGGCTGAGAACCACTGCCCTAAAGGATAACTGTCTAGGGTCATCAGACTCTAGGGGTCCCTAAGGAGTCACCTGAGGT


TTCTATTCCCACACCTAGCCTGTGTCCCACTTCCTGTGCTGATTCTGAGAGCATCCCCTTCCCCTAAGTTTCTGTCTCCAGATCTCA


CAGTCTTTGACTCTTGCTCAGAGTCCGACCTATAGTACTGGGAAACATGTACAGAACTCGGGTAATCAGACAAAGCTCTTCTCTTGG


AATGGCCAGCGAGTTTCTTTTAGATCTGTAGGTGACCCTGCGCTTTCCAAGGCCACATCCTAAGCATGACTGGCTGGGACACTGAGA


CATGGGTTTCGCTGGGGGACTGGAGGATTGGGCCAGGGTGGGAGGAGTATACGGAAAAGATGACCTTGAGCTCTCTCAGTTTGATCC


GATGATGGCTCTGCTACCTCTGATGTTAGTGAAGGTGGCTTGTCATTGGCATTATGCACCATGACAGGTTCTAGAACCTGTCCTGTC


TGCTGTTGCCCCGACTAGGATTTGCATACAGCCCGGGTGGCCTCCCTCAGCTGGACTTATCTCTAGCTGTATACACACACTTCTGAA


GTTGCTATGGAAATCCTCTTTAGCAAGATGTGTTCCAGAAGTCATTTCTCCTATGTGGGGTTGGTTTTTAATGGGACAATAAATGTT


TTTACATCTCCTCCTGCCAAGGACAGACGGGAGTTAATAATGGCGCAGAGGAGCCCTGTGTTGGGAGAGCAGCACCTGGTTGCCAGG


AGGGCAGTAGCAACATTGGAGGCTTGTTTTGCTGGGACCCCAGAGATGCATTACATCACTGCCTCCGGAGCCTGACAGTTGCAGCGC


TCAGCATTCTCCAGGATTCTCTTGGCTGCGTGCCCACCTCCCACAGGCCTCCCAGGGCCACCCCAGGAACCTCCTCATTAAACACTG


TCAAATGCCAAGCAGCAGTCGAAGGGGAACAGTGGAGGCCCCAGGTCCCAGTGCGCCAGGCCAGGGAAGTCGGCTTTCCCTGCACAC


GCTGAACAATATTCTAGCCGCCTACTTGCGCGTGTTTATCTCCTTGGAAGAAGTGGAAAGGCCTCCACAGTTCTGACAAACACAGCC


TGAGTCTTGCTTTGCATGTAAACCCTCTCCATCTTCTCGACTGGCTGGGCCCTTTTGGATTCTTCCCTCCCAGGACTCCACACTCTG


TACACAGGCTGTCTGCCTCAGGGGCTCAGGCCTTGTCAGCAGGTGTTTGGTTTTGACTGTGTGAATTTTAATTTTTTACACAGGCAT


TTTAATGAAGAATTTAAATGTAAAGATCTTGCCTGTAGAGTCAGCGAGAACCAGGCCATTGTGGGGTTAGGGTTACAGCTCAGGGGA


GAATACTTGACTCTCGTGGAGGAGACCTTGGGTTGATTCTCAGAACTGTGGATGAAGAGCAGGAGGAGGAAGAGGAGGAGGAGGAGG


AGGAGGAGGGAGAGAAGGACGAAGAGCAAGAGGAGAAAGAAAGACCAAACTATATTCTTTTCTGTTATTGTTTTTTGTTTGTTTGTT


TGTTTATCTGGTTGGTTGGTAGGCTTTTGTTTTTCAAGGCAGGGTTTCTCTGTGTAGTCCTGATTATCCTGGAATTCACTCTGTAGA


CCAGGCTAGCCTCGAACTCAGAGAGATCCACCTGCCTCAGCCTCCCAAGTGCTGGGATTAAAGGCATAGGACACCAATGCCCAGTTC


CAACCTACATTCTTGTTCTCTGTTGGTGATTGGTGAAGCTCTGAGGCAGGAGAAGAGAGGAACAATGGGCATTGTTCAATGCCATTG


GGCAATGGGCAATGGGTGTGACTTGAGATGGCAATGGACGTGACTGGAGGAAAGCAGTTTGGAGCTTGTCTCCAGGATGAGGCTCAT


CAAGGAAGCCCCCATGCTGAGCTGAGCAGAGCTTAGCCAAAAAGAGCTTAAGAATGGGGCTTGAGACTGTGGTGGTAGTGGTGGGGC


CTTCGCTGAAGCACACACTCCACTGTGGACTGTGGTGTCGGGGCCTTCGGTGAGGCACACACCCCACTGTGGACCTTGCACAAAGAT


AAGTGGGAACTCTGAGAAAATAGTAAGCACTTCTAGACATAGCTATTTTATCTAAGATAATTTGAGTTAAGCCTGTATTTAATATAC


AGGTGTTCAACACACACACACACACACACACACACACACACACACACATGCAGGGTGGTATATACTGAAAATTATTTTACTGTTAGA


AGTCTGTGCTTTTAAGTGTTTGTAAATGACTGGTTGAGGCAACTGGATGATGAATCAGGAGGGATTCCATGCGTTGGGGGCGGGGCG


GGGGCGGGGCTCACCTCTAGTCCCACCGTTAGCTGGGGGAAATGAGAAGTTGGTCTTCTTTACCAGAAACCAGTCAGGGTGGTCCTG


CTCCTCAGTAAGGAATAGAAAAATTACCCCGAAGATGCAAAAGAACATGAATTATGGGGTACCCAAAGCAGCCTTGGAAGACGAGAT


ATGCCTCAAAGTGCGAGAAAGAAGCAGTCTCTGTTACGAAGAAGACAGCAGTCGAGGAATGAAAACACACCTGCACGTGCTCAGAGC


ACCGACTTTGTGAAAAAGAAAATCCCCATTCGTGATGATGACTTTCTTCAAATGTAGAAAGTGGAGGGCCAGCTAAAAAGCTTCCCC


AGAGGGCCAGAGAGAGTGCTCATGGGAGTTAGAGCTCTGGAACCCATGTGGTGGCATGAGAACCAGCTCGTGCAGGTGTCCTCTGAC


CTCCATGGCTGTGCGCTTGCCTTCCTCCAGAAATATAAATGAATGAGTGAATGAATGAATGAATGAATGAACAAATATCTTAAAAGT


TGTTTCAGAATCTGAGAGATGAGTGGAAGGTGGTTAGCACAGACAGGGCCCATGAAGTTGAAGTTTGGACAAAAATATAGTCAAACA


TATGCATGAAAAAAAAAAAACAAAACTTTTCCAGAATGGCTGACAGATAGGCAAGGAGTTGGTAGACCCGGAAAGGCCAAGCAAGAC


ACCACCTTCTTTCTGATCGGAAGACCAGTAGGGTCCACCTCTAACATAACCACTACTGTTTCTGGAATCATAGCAAATCATAAGATT


AGCCAACCTAGAATCATAGAAACAACAAAACTGGTTTCCTCACACCCGCTAAACTTTAAGAGCCAGTAGGCCATCTTGACAGAGTCT


GCAGTCTGTGACGTGACCCCCTCTGCCATTCGAACGAAACAACAAGACTCATTATTAAGATATTAATAATGGGGGGCTGGAGAGACG


GTTCAGTGGTTCAGAGAACTGGTTGCTCTTCCAGAGGACCTGGGTTCAAATCCCACCAACCACATAGTAGCTCACACATGCCTATAA


TTCCAGTTTCAGGGATCCAACACACTCACTCACAAATATATGCAGGCAAAACGTCAATGCACACAAGATAAAAATAAAATTTTAAAA


AGATCTTAGTAATAGACTGATGTGAAAGCCAGAGAGATAGACAGAGCTATGCATGATCGCCAAACCAAATTTTAATGTCAAAGGAAA


AGTAGATTCTACAGAGTAGGTGCGTGAAAC2AAAACAATAATTCAACAATAGTTAGGGGATTACAAATATTTAGATTAAACATTTAA


AAGGAGAGGGCTTGAAGGGTTTAATTCATCATCTGATGTAGAACATTTTAATCCTTAACATTCAAATTCAGTAATTAGAAAAATATA


GTTGAGATCATAGTTTAAACCTTAAGTTTACCTCAAGTTAGGATTTAAAACAGGATTTATTTGTTTATTTATTTATTTATTTATTTA


TTTATTTATTTATTTAATTTTACATGTGGGTATTTGCCGGCATGCGTCTGTGTACCACCGATGTGCAGTATCCACGGAGGCCAGAAG


AGGGCGTCAAATGCCCCCTGGAACTAGAGTCATAGACAATTAGGTGCTGGAATCAAACCTGGCTTCCCAGAAGAACTGCTGGTGCTC


TTAACCACCGAGCCACCTCTCCAACTCCCACAGTAGGACTTAAAAAAACATACAATAAGGGTAACAGTAGCATCCCCTAAGAGTTGT


TCCACCCCAAACTATCTCATCTGTCTGAGGCCTGGGGGCTGTTACACCCCATTCCATGTAGGATGAAGCTGAGACCTGAGGAGCTGA


AGCAACGTGCAATTCCCAAACATCAGATCTACCAAGCTAAGGCAGAAGAAACAGGGACTCAGATGGGGAAACGTAAAGACAAAACAC


AAACACAAAAACCAAATGACAGAAAACCACATCTAAAAGGTATAATGATCAACATCAGTTGAGTTACCTCCTCAATTAAAGGACAGT


GTCCTTTGCTTTGATAAGATTTTAAAGCAGAAGTTGTTTTTATGCTAATTTTAAAAGAGGAACCTAAGGCAGAAGGGACCCAGAAGA


AAGTAAGAGCGGAGAGTTACATAAATTCAAAGCAGAGGGCAATGGAGACAGGCTGGTTTCATAGCACAAATTATTTTGTGGTTCAAA


GGAATCATTTAACATTTCAGATGGGAAGGGGTGTAGAGATGGCTGATCAAGTAAGTAAAAACACTGGCTGCTCTTTCAGAGGACCAG


GGTTCAATTCCCAGCACTCCTGTTACAGGATATCTGAGCCCCTCTTCTGGCTTCTGTAGGCACTAGACCCACCAGTGATACACAGAC


ATACATGCAGATAAAACACCCATGCATATGAAATGAAATGAAATGAAATGAAATGAAATGAAATGAAATAAAATAAAACCAACAAAA


ATACCATAACATAGGGTAAACTTTTGTCCAGAAAGGGTGAAATTGAATATCTGGGGGCTGGAGAGAGGGCTTGGTGGTAAAGTCCTT


GTCATGGACGTGGAGGACCAGGCTTTGGTCCCCAGAACCCACATAAAAGCCAGGTTGGTGTGTAATCTCATTGCTCAGAGACAGAGG


ATCTCCCAGCAAGCTGGATAGCCAAACTAGCCCTAATGGAAAACTCCAGGTATACACACATGCACCCCAGCGCGCACACACACACAC


ACACACACACACACACACACACACTCTTTTAAAATAAGAAAGAACACCTGAAATACTAAAAGTTTTGATGGAGAACTACCTTAAGAC


TAATAACCTGACCAAAGATGTACTCAGATGAAAAGTACTCTCAAAGTTTTCATTATTAAAAAGTAAAAAACAGTGGAAAGATTGTGC


AGTAGTTAAGAGCACTGACTGCTCTTCTAGAGGACCCAGGTTCAAATCCCAGCACCCACATGGCAGCTCATAACCACCCTTAATTCC


AGTTCTGGGGGATCTGACTCCCTCTGTGGCCTCTCTGTGTCCTGCACAAATGTGGTGTACTGATGTACATGCAGGCAAAACACCCCT


ACAGATAAAATAAAAATAAATACATATTTTATTAAAAGTGAAGAAGGAAGCCAGATACTGTGGAACATGTCTATGTATATGTGTCAG


GGATCTGAGGCAGGAGGATTATCTTTAGTTTTAGGCCAACATGGGTTACATATTGAGTACCAGGACTTTATACCAAGATCCTGTCTC


AAAAAGCCAAGAAAAAGAGAAGAAGGAAAAGAAATTATGTTTATTAGAAGGATGAAACAAACCTTAGATGGAGAGCAGACTAAATTT


ACAATGAAGAAACGGGAACTAATAAATTTTTAAAATGGGATTTATAAATCTGAAAGCTGACAAGTTTAATAAATTTAAACAATTTCT


GCTGTATTGGAAAACAAAATTAGAAATTTTAAGGGAAAATAATGAGTGATTCATAGGGCATTTTAATCAATAATCGAGAGCAGCTTG


GCTCATACAAGAGAAGCCCAGGAGGGAACTTTCCCTCTGGATATTAAAATGTATTATAAAACAAAGAATAATTAAGTCCCTCAGGCA


TTACCCATTACTAAAGAACCCAGTAATGACAGATCGATGAAATGCAATGGAAAACCCTGAGATAGAGCCTAGTGTGGAAACCCAGTC


ATGGAGAAAGAAAACCAATTAGGAAGCAATAGATTACTCAATAAACGTTCATGGGGAAATTGGAAGCTTGGATGAAATATCAAATAG


GCACGCCACCTCTCAACAGCCAGCAAAATAAATTCCAGGTAGATTAAAGAGTCGGATAGATATGAGGGAAGAAATACGAGCAGGAGC


TAGAAATCAAAGTGAATATTTAATCAATCCTGGGGTGAAGAGAAATGTTAGGCAGAACATCTCAGGAGAGAAGAGCTGTGAAAGGAA


GCAGGCATATTTGATTACATCATAAATACAAGTGTAGATTTCTGTCCTTTAAAATATATAAACCAGGGCTGGAGAGATGGCTTAGTG


ATTAAGAGCACTGGCTACTCTTGCAGAGGACCTGAGTTCAATTTCTAGCACTTGCATGGTGGCTCAGAGCCATTTGTTACTCTGGTT


CCAAGGTATCTGACACCTTCTTCTGACTTCTACAAGCATTAGGCATGCCAATGGTGCACAGACATACATGCAGGCAAAATACCCATA


CACACGATATATATTATTATTTTATTTACTTATATTATAAGCATACATGTTAATTAATTAATAATTATTATATGTAATAAGCTAGAA


ATGGTGGACCTTCTCTGTAATCCCAGAGCTAGGGAAATGGAGACAGGAGGCTCAAGAGTGAATTTAAGATCAGCCTGGGATACATGT


CTCAAAAAAAAAATCTATTTAAAAGCAAATGTTATATTTAAGAAAGATATTTGCAACAAATGTGACAAGAGAGAAATATCTCATTGT


CCAAAGCAGTCCTGGAGATCAGCCACAGTCCACCTCACAGCTGAAGGCAGGCACAACATAGAAGGCACACAGCGAAGACACCAACAT


GAAATGCAGCGAGTCAGCTGTTAACCCTGAGTTTGCCGCAACTTGAACAGTGGGAAGCTTTCACTTGTTGCTGTTAAGGTCTTCCTG


TTGATGGTGGGGGTGGGATTGTGTCTCACACTAGAGCAAACAGGGAATTTAGGACCATCTTTCTGGAAACAACATTGCTGGGAAGCC


CTTGACGGTTTATGGCTTTAACCTACTAAATATCTTTCTAGAAAGTTCTTTGAATCAAAGACTCAACTGATACTCGAGAGTCTTCAA


TGTAATGTTTATAATATCAAAGACTCAGAAATGAAGTGAACATGTAGGATTTAAATGCTTAAATAAAGGGGCTGGAGAGATGGAGGT


TCAGCAGTCAAGAGCACTGGCTGCTTTTTCAAAGGATCTGGGTTTGGTTCCCAGCACCCGTGTCAGCACCCGTGGCTGCTGACAAAC


CTGTAACTCCAGTTCAGGGGATCTGATGCTCTCTTCTGGCTTCCCTGAGCACTGCATGTGCCTAGGTGCAGGCAGGCAAAACACCCA


TGCACAAAAACTAAGACCTAGAGTCTTTTAAAGCATGTTTGAATAAGGCTTGTGCATGCCGACAGCGAGTTCTTAGGCAACGATGTT


ACAAGTCCGTACTGATGTGGGAAAACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCTAATGGTATTTTTGTTTGTTTGTTTGTTTTGTTTTGT


TTTTCGAGACAGGGTTTCTCTGTGTAGCCCTGGCTGTTCTGGAACTCACTCTGTAGAGCATTTTTTACGTATATATGTGTAAGAAAT


GGGTTTGGGGGCCACAAGAAAATGACCCCACAATCCAAAGCCTTTCAGTAAGGTGGTGAGTTTTACTTGTTCGGGAGGGGTGTAGCC


AAGGCAAGCATGCAAGCACACTCGGCAGCAGGGCTGCCTCTGCTCTCTGTTCCCTAACACACAGATCCCATGTTTCCATTTTTCTGT


GATTGGCCAGCTTAAAAAGCCCAGTTTATAAGCAGAGCTCAATCTCTTGCCAGGTGCAACCCTGAGCAGGCACATATTTTGATTTCA


GGAAGTGCTGACTCTGGAGGAAATTTTAATTTCTGCCAAGTGACTGGTTAAAAAAAATTAATAGGGTTTTGTCTTATTTTAACCCTT


TGACAGAAAGACAGTGCAATTTGTTTATAATTTCCACACTATATACTTTTGTTGTTGTTGTTGTTGTTCTGTTTGGGTTTTTTAATT


GTTGTTATTGTTCTGTTTTGTTTTTTGATTTTCCACACAGGGTTTCTTTGCATAGCCCTGGCTGCCCTGGAACTTGCTTTGTAGACC


AGGGTGGCCTCGAACTCACAGAGATCTACTTTCCTTTTCCTCCAAGTACTGTGATTAAAAGTGTGTGCCACCACAACCACCATGACT


CAGATCTGCATTTTTAATGGAGAGAGGCAGCTGGCTTTGAGATTTGGACAAATGTCATTTTAGCCTCGGCACGAAGCCTTGTCATCA


ACAGGGCTTGGGGAGTAAGGTCGGGTGGTACAGTTTCCACATTTAATTCCCTGGAGGATCACCAAAGAGTTCCTTCAGAAGGGCTCC


CCTTCCTATCTAGCAGCTAATGGCCTTAGAGATAGGGACAGTGACTGGGCAGGAGGCTTATGGGTCATCTCTCTGGGGGGCCTCCCT


GGGTGGGCTTGTGACACTACCACGGAGTAGGTGGGTGAGGCTCACAGATGCTAGCTTGCTTGGTGGCAAGATAAGGGAACACTGCAA


GTTAGAATGCATTCAGAAAGCACAGAAAAAGACGCTGTGGTCTTCCTTGCAAGAAAGGTCCTGCTACTGAGCTGTGGGACCTGGGTG


AGAAACCTTTCGTTCTGCACCTGCCTGGCCACAGGGGCAGCGGCACCCAAATCTCCTTTGAGCCCAGAGCAGTGAGACCCTGGCAGT


GTGCTGCCATGCCCAGGTTCAGCCGGCTGAAGCCACGGTGACTTCAGCCACCAGTCCCAGGGCCATTTCTTCTCCCTGTCACTAGTG


ACACTAGTCTCAGGTCTCTGTTTTGAATCTCTTCCATCTTCACTTTTTTTCACAGCTGAGTTTCTCTTTCTGTTATTTCTGATTCAC


ACTTGTTTTGTTTTATTTCCTTTGCATTATGTTTCTGCTCTTTGGCACTTAAAGAGCAAAGTTGCATATTTGTTACTGTTTTCTTCA


TACTTTTATTTATGTTAAATATACATTAATTGTAAGTTGCGTTCCAATTAAGGGATGGCCTCTCTTAGAAGAGTCTATAAACGGGAA


TCAGGAAGGTTTCCTAACATGGGCAATGCTTAGTTCTGGGTACAGGACAGCACCTGAGGGTATAGTGGGAAGCTCTGCGGTCTCTGC


ACACCACCCAGCTACTCCAGCCTGTGGTACAACTGTGAGGTTTCACTCCTCTGTCTTTGGCAAGCATCTTTTCCCTCCAGGATGTCT


GCTTTGGGGTTACCCACAGGAGTGGGGGGTTGTACAGCTTTTCTCCAGCCACAGTGCAAGTTGCTTTTTTTCTTACAGTGGATACTA


AGGACTCCTGTACATGTCCAGAAGGCCTGGGCTCTGAGCAGAGGGGAGGACTCAAAGTTTGCCAGGCTGGGGCTCCTTAGACAGTGA


TGGAGGAAAAGGGTGAGGTTCTGTGAGCAAAAATTACCCATGTCTGTCTCCCAGCTCAGGTTAGCCCACACATGAAATCTGTCTTCT


GTCGAATTTCCCACTTTCAACCCTTGGCTGCTTTGTTTGGTCCTTCAGACCCCACCGTGTCCTTCATCTCCATGGGAGGGACCTTGG


CAGCAGTGGATGGCCGTCTCTGCTCCACAGGGACTGAGCTCCGTGTTGAGGGTTGACATTCATTGCTATGGAAACCTTTCAATCCTT


TCAATAGGGGAGAGCCATCCGAGCCACGGAGGGACTGGCACCTTCACCAGTGCCTGACAAGCAAGGAAACCTCTCAGAGAACAAGAG


GCTGGGGGTGGGGGAGGCATCCCAGCAGGCCAAGCAAGGGACACATGTGACTTAGTCTTACATTCCAAATACATCCTTGTGCCTGTG


TGTCCTCATGCACTAGTGTCCCAGGCACTGGGTCTATGCTTGGACTCTCACATTGCCCTAAATTCTCTCTGCTTTACTGTTTTGCTT


TTTAAGATTTATTTATTTAATGTATGTGAGTACACTGTTGCTGTCTTCAGACACACCAGAAGAGGACATCAGATCCCATTACAGATG


GTTGTGAGCCACCATGTGGTTGCTGGGATTTGAACTCAGGACCTCTGGAAGAGCAGTCAGTGCTCTTAACCTCTGAGCCATTTCTCC


AGCCCTACTTCACTGTTTTTAACTCTTGGTTCCCCCCTCCTCCCCCCACCCCCTACCCCCGGGAACTTTATCTGTTTTGTTCTATCA


TATTAGATTTTTGACTCTGGCAAAGAAATTAGAAACCTTTAAACAAAATAGTAAAATGTTGGAGAGGTAAAAGAAGATGGAAAAAGG


GTCAGTCTAAGCAAGAAAGGAGTCTGAAAACGTCAGGGGCAGAGGCTCCTCTCTTGTTACCCTACTGAGCTGGAGGCGTGGCTTCAC


TTCTCATTGAAGGCGCTGGAGCTCCATCAGCACATCTACCTTGTAGCCAGCAGGAGGAAGAATGTATGCTGCTCTCTATGCAGGCAT


GCTCTGCGCTCTATGGAGCCATCCCACTCACACTCACACTCAACATTTCTGGGGCTGGGGAAATGGTATCTTTATCACTTATGTTAA


TAGTCCAGGTTTGCAAAAATGGACTACTGGGCCACAACTGCTTCCAAAGTCAACATTGTTAGTTATCCTGTGTCCCTGCCAAACCAA


TCCAACTCTCCACGAGGGGTTTCAAGCTCTGGTTCTTGTCTGTAATTCCCCTCAGATTCCCCTTTCTCTACACCTGCTGGCCCGACC


CCTGCTGCTTCCCTGTTTATAGAAGCTTCAGGTTCTGCTACACTCTCGTACCCTTCAAACGCTCCCCGTGTCCCCAACAGAAGGTTA


ATTCATACTCTGCTTAGAGTCTGCAGCTTCCACTGCCCAAGGCCAGTGACCTATGATTAACTGGCTGAGGCCTAGCAGTGTTGGTCA


TAATGCCACAGATCTCTTCATGGAAACTTTATTGTAGACAGTGAAAAACATTGCACAGGAGTGAGCGGGCCTGGGCCCCAGCTCCCA


AAATGGTGCCGGCCTGTGTTGCAGCATCCATGAGGTCTGGGAGGCAGAGGCAGGGAGACTGTGAGTTTCCAGCCAGCCAGGGCAGCA


TAATAAGATCCTGTCTTTAAAAAACAAACCGAACAGGACAGGGGCTGCTGATTATGGCTCAGTGGGAAAAAGGGTTTACATTCTAGC


CTGCCAACCTGCATGGCAGAAGGTAAAGAAGCGAGAACCAAGTCCTGTAAGATGTCCTCTAATCATCCTTCAAATGTGCCATCATGT


GTATACACACGCACACACACAGAGGCACACACCTGTGTACACATACGCATCCATGTGTGTGAGCACATGCATGCATGCACACATATG


CTCATTCACACACCATACTTGCAAACAACATACACACACATCCATGTGTGTGAACACATATGTGCATGTACTCACATCTCTGTACAC


ACAGAGAGATGCACAATACACATACGCATGCACGTGTGTGAATGTATATGTACACATAGCACACATGCATTGTGCACACACACACAC


ACACACACACACACACACACACGAGGGCAGGGAGGGGAGGAAATAGAAAGGAGAGGGAGAAGAAAGAGGCAGGAGCAGAGAAGGTGG


GAAGAGAAGGGCGAAGAAAGCGAGCTCAGCCCATTGCCTCACAGAGCCTCTGACTGTGCCTGGCTCTTAGCCAGCCCCGGACCTTCG


CCCTGCTGGGCCCATGTTCCTGTCTACAGATGGGAGTCAAACCTGCCCTGCTTACACCCTAAGTGGGTTCAAGAAATGGAAGAGCCT


AGAAGCTGGGAACCCCAAAACACAGCTCACATGCTCTCCTGCTACTCCTGACCCACAGAGCAAGTAGGCAAGATGAGAGCAGGGGAA


CCCCATCTGTGCATAAGGATGCAGGGACTCTGGCAGCAGAGGGCTGAGGCCTGGGGTGCTGAGCTGGGGAAGAGGGGGAGGGGAGGG


GAATGAGTTAGCTTTGTCTTGCATTCAATCCAAGTGCTTATTTTACAACTTCTTGAGGGCATGCTGTCTGGTGTCTCAAAAAAATAT


GATTGGTGTGATTTAAAAAAAAAAACAACAACAATAGTGATTTTCATAAGGGAGCAGATGGAAATGGCCTCCTGTTCTTTGGGGGGG


ATGGCAGGTGATTGGATAGGCTTTTCCTGGGAAATACATACCCAAACCAGTATAGTTGCCACTTATATTGTCAAACTTACAGAGTCA


AATGAATGCTGCAGTTGCCTGGCAGTAGTTTTTAATTAGCTTTTTTGTCAAATTTAACACACCATTGTTCTCCTTAGCAGTATTCTT


AATGAGCTTTGCCCCTGTTTACAGTTTCAGTTATAGATTTTATGTAGGGAATAGACATATTTTGAGGTTGTCCATTACTTCAGAAGT


TAGACGGTTGCCTCCTGGGATTATCAGCCTGTCACTATGGGACAAGCTTGTCAAAGTGCAGCACAGGGAGAATAATGGGACCCAGCC


AGACTCAGAGGAAGTCTCAGAGGAAGAGAGAGCCCTTGCTTGCCAGTGCTTGCTGCAGTCTCTGCCATGATGCTGCCTCCTCACAGC


GGCCAGTGATCTCAGTCACGCTGCAGGCCACCTCCATTTCAATGATGGAAACCCGGAGGCCTGAGTCAGGGCCCCTCCCGTCATGGC


TGAAGTTGTCGTACGTACATATGGTCGCCTCGGATAGCTCTTGGCAAGTCCATCTCACGGGGTCTCCCAGAGCACTGCCCTTGCAGG


AGCCAGGGCTTGCTCTGCAATAGACAATGCAGTTCTGTGCTCCCTGGTCCCGCTGTCATCTTTGGCCTTTCCCAGCACTGTGTGGTA


AAGGGAGTAAGACAGGAGTCATCCTCCCACTCTAGAAATGTAGAGGCTCAGGAAGCAAATGCATAAGGAGGGCCTGACCTGGCTGGG


GTCCCCTGGGCAGCCACGTGTGGTATCTTGTGTCACAGAGCCCAGGGTGCCTAGGCCAACGAGAAAATAGATGCCCCGTGTGGATGC


TGGCTGGGGCCATCTTTATGTCGGAATGTAATTTTGAGTCTTTGAAAGTCAGTGGAGAATCAGGCCATTGTTCAATAAAAGCACTTG


TCAGTCACCCCCATCATCTTCCTTAATTAAACCTCATCCCCAGTAGACAGGATCAGTACAGAAGAGAGGAGGCCTTGCAGGGAGCTG


CCCCCAGCCAGCTTCCAGGCTGGGTTCCTGGTCTCCCTCCATGTGTTGAGTCATTCCTTCCTCTTCTGCATCCGCTTGGCTCTGCAC


ACCTGTGGGCTCACACCTTCCTCCCTGGGGTTCCCCCAGCTCCAGCACCACCACCACCACCACCCCCCACCCCCCACCCCCGTCCCT


CCACATGTCCTTTGTTCCATGCCTTGCTGCTCTCATCTGAGGGTTTCCAGTCCTGTGAAGTGTCAGAGGTGGGCTGTAGTTTTCAGA


CATCTTTGTTGCCTAGCAACATGCTACAAGCACCTTCTTCTGTGTGGCTGCTTCCTCTAAAACAGCTGGGGCCAGGGAATGGCGGGA


GGGGTGACCAAGGAATTCTGAGGCCTCTCTGGAGTAATGATGGGGAGAGGAAGGAAAGGGACAGACAGGCAGACACACCCGACTGAC


TGACTTTCTTGCATAACTTTGAGTGTAGTCATTCCCACTTTTCAGTGGTGTAGCTGCCAGAGTCTGCTTTACTGTCCTGTCATAGAT


CCTTGCAAGTGGTCAGTGGTCAAAGTCCTGACTTGGAAGCCATCAGAGACTCTTGGAAGTCACTACTGGCTTGGGGAGGCACCTGCA


GTGACTGCCTAAGGCAAAGCCAGTCTGAAGGCTCCCGACTGAGCTGGCCTCTGGCTTCGTCTTGTTTCCTGAGATGCCATAGCCCCC


CTGTCTTCTGCTTGTGTAGCCAGCCCAGCGATAGTTGCCCTGAGAGTGGGAGGGGAAGATAGGGCAGGAGAGAGAGTGGGATTTTAA


AATGAAACAGGGGCTGCGCAGTGGTAGCACGTGCCTATAATCCCAGTACTTGGGGGGCAGAGGCAGGTGGATTTCTGAGTTCGAGGC


TAGCCTGGTCTACAGAGTGAGTTCCAGGACAGCCAGGGCTATACAGAGAAACCCTGTCTCAAAATAAACAAAATAAAATAAAATAAA


ATAAAATAAAATAAAAATAAATAAATAAAATGAAACCGGCCAGAGAAAGGGCTCAGTGGGTAAAGGCATCTGCCACCAAGCCTGAGT


GTGATCATGTGCAGATTCAAGACCAGCCGCTTATGAATCTGTCTTCTCAAAGATGGCCTGTAAGGGCCGAGGGTGCTGTAGATGCTT


GGTATTGCTCAGTCTGCCCTGCTGGTGTGGGCTGCTGGGTGGAAAGCAAGACAGTGCTCCAAAGATCACAGCCACTCTGAGATGGAG


GGGCCCGTACCCACAGCCCCCACCCTTCATCTACATGAGGACAGTAGGCCCCAAGTGATAGGTCCCAAGCAGCACAGATCACACCTT


CCTCCAGGCACTGCAGTTGACAGAAATCTCTGTGGGTCATCTTATCTTTGCCCTGCCCCTCATTTTCTTCCAGCAAGCACCTCTTAG


TTCAGGAGGCAGGGAAAAAGAGTTCTAACAGTGGCCCCCCTATGTGGTTATAGAAGTGGCCTGAGGTTGTGGCCTAAGTCCCAGCCA


GGAGCCCTGCTTCCAGGGACTGCTCTCATGGGTGGTAGGGTGTGCCATCTTTGAAGACTTAAAAGCCTATCCAGCAAGAAAATTCCT


CTTGAGGGGCGAAGTTGGGTGTGATTGGCTCTCTCCATCCTTTCCTTCACAAGACTGAGCTTCAGCCTCTGAGAAGTATTCCAGAAC


CTTCCAGCTAATCATACAAAGGGAAGTTTCAGGGACTTGGCAGTGGCAAGGGCAGACCTGAGCAAGCTCCTGAGGACTTATGGTCCA


CCTCCCCAACACTTGGACACCCTTTGCTTGAAAATATGTGGTGGTCAGGCCAGTGGGAACACCGAAGAAGGAGATAGCATAGTCCCA


TACCTCTGCCACGAGGGCAAAGGCTAGCTCTGTCCTCTGCCTGGCCCAGATGCCTCTACAGTGACCTCTTTCTCTCTCCATGGCTTT


CTAACAGCTGCAAACTTAGCCTCCTAGAATTCTCCCATCCACACCCCCAGCCTCCAGGGTTCCTCTTTAGCACGCTACTTCTCAATG


GCAGGGGAGGTCTCCCATCCAAAGCTCTCACCCCTTGCCCTTGGGTAAATGAACAAGAAAACCCTTTCTAGGGGCATCCCTCCTGTT


TCTGCCTGTTCTTGGTCACAGAGTGATCTCCACCTCCCTCCCACAGGAACCCTGTCTAGGTGAGACATTTGCTTGCCTGGCTGCCCA


CTTTGCATTCTCTGAGAAAAAAAATCCCCTTCTTTCCTTTGGGGCTCTATCCAGGACCAGTGTCTCTGCAGGAGTTCCCTCCAGGGA


GTGCCATTGAAGCCTTTGTGAATGTCAGTTGCTGCGGCTGTATATAACCCACGCAGCTGAACAGGACAACCCTAGCTCTAAGTTACA


AGGGTTCTTTCCATATAGAGATTGAGGCTCAGAAGCCAGAAAAGGGGAAGTCCCCAGGAACCTCCCCACCCTACTTCCCTGGGCCTT


TGTTTTTTTGGAATCATAATATGGTTAAGCACAGGGCTGGGGACTTGGGCAAAGCAAGCCTATACTCAGTTTAACTGCTCAGTTGGT


GTTTATTTATTTATTATTTTCTTATTTTTTGAGGTGACAAAGGTTGAGCTCAGGCCTTGCAGATGCTAGGCAAGTGCTCTGCCTCTG


CTTTGTCTCCATCCCAGATTTTGTGTTCTTGTTTGTTATTTTAGTCCAAGTCCTGCTGTGTAGCTCAAGCTGGCCTTGAATTTACTT


ACTATGTAACCCAGACTATGTTCGAATTCTAAGTCCTCCTGTCTCAGCTTCCTGAGTGTTGGGATTATAGCGTGTACCTCCATCCTC


AAGCAAATGTTTTATTTTGTAAATATCTCCTAATTAGGTTAAACTGAGTTTCCAATCAGGAAATAAGAAATGATGAGAAATCATCTC


TCATATCAAAGAGTGCATACAGTTGGCACACATGACTCAGTGCTGGTACTCGATAAATGGTAACAATGGTTATTCTTTCTTAAAATA


AAGCTACCACCCGGCCCTACCTACCTCATAGAGATAGCTCCAGAAATAAAGTGAGAAATAGAACATTACCATGATTACAGAGAAAAT


ATTTTGCAAGAAATCCAACTACTTTTATTTTTGTCTCTGTCCAAGAGGACTCAGCCCTCTGAAGCCCCTTTGCCTACAGCAACACTC


TGTGACAGATGGCAGATGTCAAGAAAGGCTCAACCAGGAGAGAGAAAACAACCAGACGCGGAGAGAGGCCCTGGGCAAGTGGAGTTG


AATAAAAATCAAAGACAGAAGAGGCCCATAGCGGAAAGAAATGAGACAAACTTGAAATGCCATTTCTCCCAAAGCCACAGTTGATTC


TTGCCTCTTTCAATAGTTTGCCTGGTGCCACTGACCTGGCTGAGGGACTGGGCCACGTACAGATGGGCAAGGCCTGTGCCAAGAAGT


TACAGGGAGCTGACAAGCTCAGGGGACACTTAGTCAGGAAGAAAGTCTAAAGGAGGTGATGTCTTCTGTCCAAAGGGGTCTCCAGAC


AGGAAGAGCAGTGTGAGCAGCCTCCAGGAATGTGAGAACAGGCCATGGAGAAGAGGCAGCTGTTTGCTGAGAATCAGGCCTTCCTTA


GAGCCAGAGACGGAGGCGGGAGTCCCAATCTAACAGCACAGTCCTCACTTGGTTCTTTAATCAAAGCCAACAGTTCCTAGACTGATT


TCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTCCTCCTCCTCCTCCT


TCTTCTCCCCCTCTCTCCCTTTCTTCCTTTTGTTCTTTCTGTTTTTTCTGGTGACAAAGGAGAGCTTCTATTCAGATCCCTGGCTTC


TGCTCCCCATATGCCTCAGGTGTAAGTCATTTCCATTATCATAGCTCTGAGCTTCCTTCCTATGGAGGAAAGCAAGTCAGAATCCTG


AACAAGGAAGGTCTTTACAGGGCTGGGAACCAGCACAGCCAGAGGGCAGGTGCCTCAGCCTTTAGGAGTCTCCGGAGGACATCTCTT


CTTCCTTCTCACTTTCCAGTGGAAGCTGTTGTTGGACGTGCCTGTGTTTTGTTTCTCGGCTGCAGTTTAGAGGATGCTAAGAAGGCA


CAGGCTGACCGTGAGGCAAGGTGCCCAGTGGGGGCACTGCTCGAGTGATGTGCTGCAGGACTGTGGAGCCTAGATCCGCAGCATGGC


TCACTGGGCACACAGTGATGGTAGAACAGACTCAAGAACAATGCCTGGGTCTTAGAGACTGGGAAGTGGTACTGCTTACGAGAAAGG


GAGACAAGTATGGAGGGGATCTGGGCATCAAAGTAAGGCTTAAGAGTAGACTCAGAGATCAGTTGATGTATCTGCTGCCCCATCCCC


ACTCCTAGGTTGCATGCCAGCAGACAATGGCTCTCCTCCTGGCTCCCCTTCCTACTCACTTTTTCCTGCCCTGACTCCTCAGGGGCG


CCTTGGAGTTGGGACCTTGTCCTGACCGAATTTTCTGCCCCCAGTATCTGATCACCTGATATCTGGTTGGTGTCCCCATGGAATGGT


CCCTTGTGGAGGCACGAATGACCTTTTTTTGAGAGTGGGGCTCCCACTCTGAGTCCACCCAGGAGGCTGTGTAAGTGAATGGAAAAC


ATGAGAGGGGAAAAGAAAGAGGAGGGAAGAATGACAGAAAAGACAGACAAGAAAAAGGAGAAGGCAAGGGAAGGGCGGCGAAGGAAG


ATGCATGGTTAGGGAGAGGCAGCCAGCACAGGCCCCCGTGCCTCTCACATACTAACACCCTGAACTGGTGATTTGGGGAGAATGTGT


CTTGACCTGCATAGCTTCCATGGCCTACCTCATTTGTCTCCTCAGTTACCCTCCTCAGCTGGGCTCTACCATGTCAGTCATTCTGGT


GGCTCCTTATAAGCACACTGGTTTCAGAGAAGGTCCCTTGTTCCATATGTGTAGGCCCATGTCTATACACTTGTCTCAGTTGAACAT


GGCTTTTGTCACAGTGGCATTGTTTGGAGTCTAGCTTCATGATGTAGATACCAAGTCCAGCTCACTCTTCCTCATTGACTGAATGAA


GAGGCTAACTGAGGCCAGGATGTGTGTGAAGAGCTAAGTTCGATGGGAGGCATGTTCGATCTCTCCTGTAATGGTCCCACGAACCCA


GGAGAGCTGCAGTGCGCTCCCTGTCAGAGGGAAAGCCTAAACCGTGGAGAGACAAGCACCCAGCACAGCTGGTTGCGTGGCTGGTGC


GGGGAACCTCCTGATGGTCTCTGCCCACGCCCTCTTCCCCACATACAGCCTACTGCCCTGGAAGAAACCTCCCCAGGAATAGCGCTT


CTACCAGGCATTGGTTTTCTCCATTTCCACACATCCTGTGTAACATTTCTCAATCATAAAACATGGAAATATTTTTTAATAAGAAGA


AAGAAACACTGCAAATTGAGAAAGCGTTGCCAGATGAGCCATCTGGTTTTTGATTTAATAACCATCCAAAGAGGTGGACAGCGCTCC


CTCTGAGAAGATGGACTGTGGAGGGAACAGCAGCTGGCTTCCCTCACACGCTGCTTCCTCTGGCAAGGTTGGAGTGGGGTTACGGGA


GTGGAAACAACCAGAGATGCAGGGAAGCTCAGCTGGTGTCATCTAGATGTCCCTGGACTCTGGTGGCTTCCCTTCCTCGCCTCTGGG


CACATGTTGTTAGTTCTTAGGCCTAGAAACAAAGAGCTAGACTTAGATGTGCCTTGGAAAGATCCATCTGTCAAAGGGGAGCATCGC


TATATCTCTAAACTCCAAGTTAGCTCTTGAAAAGCAGTACTGGAAGTGACTTTTGCCTGCGCCATGACAAGTGTTCTCCAGGCCTCG


TGCTCGGCCTTTTAGCTCACGTCTGAAGACGTTTAAAGAAGTAGCTGACTTTTGGGTGGGGTAAGCAGGAATAGTTCTAACGTCCTT


GAAGCCATTTACTTTTCAGTTACCTCTGAGTTTCAGTGACTTCTTCACACACCTCCCACATTTCCCGAGAGCCCGCAAGTCCTTGAC


AAATCATAGCAATGGCAGGCCCTGGGGTGCTAAGGATACTTGATTCTTAGAGTCAAGTAGGGACCTGGACAAAGGCAGAAGTAAGGA


CTCCATGACGTGTCTCCCCTTCAGCACTAGTGTATCAGGATCCCTCTGAGGAGCTGGCAATAGCCAGTCACACACACACAGACATTA


GCCGGAGACAGAGGTACTGCCAGACCAGGGTCAGAGGCTGCCCCCATGTCTTGTCCTGCCTACTGTGGCAGCTGCACCTGGGCTGGA


AACAGAGATCAGGTTCCAGCCTTCATCTCCTTTCTCTTGCTGGCGGAAGCCAGTTTGGTCAGTTATCATTTGGGGTTTTTTGTTGTA


TACATGTGAAATTAAGGCAACAGCTTTCTAGCTCTGTTAACTTTGGCCTGCCTGCTTGTGCCAGGGCTCTATGACTAAATGGGCTGT


CCCCTGTCTTCTTCCATCCATTTGCTTAGAAAGCATTCACTGAGTAGCAGGGACGCATTGGTAAGGGGGGTGTGGCAAATAGGAACA


GCAATGACAAAGCCAAAAGTGCATCATGTTGGATGTTGTGCAATGCAGGGGTGGTGGGGAGGAGGTGTCCTAGGACAGGAAGCCGGG


CTTGGTAAACGCATCGAGGATGCAGGTGGGAACAGGGTAACCTGGAGTTTTACCAAGACCCTGCCGTGTGAGCCAAGGACTACTGTT


GTCTGGGAGCATCAGTAACAAGCAGGAAAGCTAGGAGATGGTACTAAACCAGGCAGTTTGGTCGCTGAGTAGATGTCAGAGGAGGAA


GGGGAGGTTTATGGCACAGGAGCTCACAGAGGCTCCATGGGTCTGCAGGGATAGTCCTTAGGCACTTGAAAGTGCTGGTGTTTGCTC


TGAAGGACCCAGGGCTGTCTGTCGTGTTCTTTGATAGGCCATTCCCTTGCTGCAGTGACACTATGTGGCCCAAGGTGTGGCTGTACA


AGCTGAAACAGAGAGTACAAATTAGCCAGCACCTCCATGGGCCTTGTGACAGGACAAGGAAGGCCTGAGTGCTCACATTCTGGAACT


TCCTTTAAGGCAAAGATTTGCTGGAGCCAAGGAAGGGGCAGTGGTCCACACAGAAGGCAGAGCGACCTGGCAAACTGCAGAGAAGCT


AGGCTTTTCCCGAAAAGCACTGATGCCTGCTTTCCCTCCACGTCTGTGCCACCGTCCTTGCCACTAGGGCAGAGCCCCAGGTGGGAG


GCTCTTCCGGAGGCAATCACATGCCTCTATCTGTGTCACGCACAGAAGGCTGACAGCTCTTCCACACTCTGGTTAGATAGGGCTGGA


GTGATTAGACCTGATTCCCTGAAGACAGGACAGGGACAGGATTTGTTCAAGGTCACAAAGCCATTAAGGTATGAAGGACAGTCTTTG


GGTGCTTCTCCAGTTCTGCTGAAACAAGTCTCACCCAGGAGACTGTCATGACAGAACAGCTAACAGTACTTAGACCCGTGCCAGGCT


CTGTCCTCATTCACTGAATAGGAACTCTGTGAGCCGGCATCTCCTTTTACTGGAAAACCGGGGGACAATGTACTGCGTGTACCGTGG


GGATGGACCAAGAATTTGTGCTCTGGTCCCAGAGCCTGCGTTTCACATTGACACCAAACAGCAGCACAGAGCCAGAGCAACAGCTGG


GTAATGAGGATGCTCTATGGTGTGGGCCAGAGCAACAGCTGGATAATGAGGATGCTCTATGGTGTGGGCCAGAGCAACAGCTGGAGA


GTGGAGGTGCTGTATGGTGTGGGAGTCAGGGGAAGAGCTCCAGCCACCAGAGGGTTTGAGCTGGGTCTGAAAGGATCAGTTAGAGGG


ACCAGTGAAGACCAAGGCAGACATGGTGGGATGGAGGGGCATGTGCACAAGGCAAGCTTGGGACACCAAGGAAGTCAGGGCAAGAGG


CTTAGAAAGCAAGGCAAAAGGGGGAAAGGAGGACAGCAAGCTACCGAAAATGCCAAGGGGCAGGGTGATGTGAGGAGAGCAGTGCAG


TGGGGTCCGAGGCTGCCATGGAGCCACATCCATGCCGCGAGTTCTTCACTGGAGACCTGAGCAGGGACTCCAGGCTCAGCGTGGTAT


TTGACTATGGGAATCTGAGCGTGAACTCCAAGCTGAGGCCATCATCCATTTGGAGGGAGTTATGCGGAAGGCCTGGCTTGAGCTGTT


CGACATTCCAACAAACAAACCAGCCCCAGGACAAATGGCTGGAGCCATCATCCTTGGGATCCATATGGAAACACTCCTGAAGGAAGT


CTACTTTACACAAGTGTCCAAACTCATTTGGAGACAAAGGGAAGAGGCGTATGCTCTTCACGTGGGCCTTGCTCCCGTCACCCTGTG


CTGGAACGGGTCACAGCCAGTGTCAAGAAGCTGAGTTCTTATTAATAGTGAGAACCAAGTCCTAGCTCAAGGAATCTGGCAGCCAGT


TTGAGAAAAGTCAATGACTGAAGACAATGGCTGGAATCCCACCACACTCTACTGGGCCACTCCAGTTGGTGTTTCTTTCAGGATGGC


GCAGGAGCGGCAGGAAGAGCCATCTTCGTGCCACAGACGTTTAGTGAGCACCTACTACATGATAGGCATGCAGCTGGTACCCAGAAA


AGGCTACAAAGAGAACTCTTATGTAACTGTAGGGTTAATAGGCCAATGGAACAGTGCGAAGAACTCAGAAATAGAACCACTTCCACA


TGGAGGAAGCACGGAGAGTCAGGGGGAGGAAACCAGTTTCAGAGGAACTGCAGAAAGTCTCATGATCTCAGGAAGAGAGGGGTTTCC


TAAACATCACACAAAGCGCTAAGCTTAAATGACAATGGAGGAACACAACTTCAGTGAAGTCTAAAATGTCCATCAAAGACACTTTAA


GGCTGGCAAGGTGGCTCATCAGGCACAGGCGCTTGTCATCAAACCCAACGATCTGAGTTCCATCTCTGATCTACTTGATAAAAGGAG


GAAATCTTCTACAAGTTTTTCTCTGACTATCATATCATATCATATCACATCATATAATATGAGCCCCCCCATAAAAAAAAACAAATG


TGATTATGATCTCCAAGGGTCAGGCATTCCAAGGCATCTTCAGTGGGTACCTCTGGCTCAATATATCTCATGAAGTTACGACCTTTC


TCTCTTCCAGTGTTTAGGGGTCCAAACTCATCCCTGTGCTTGGTGGCAGGGGGTGGACCCTTACCATGGGGGCCTCACCATTGGTTT


GCTTCAAGACACGGCAATGAGTTCTCTCAGGAAGAGCAATGCCAGAGAGGGTAGGGGAGAGATTACCAAGACAGAAACTACAGCCCC


GCCGCAGTCTAACTTCTGAGCTCTGTGTCAGTCTAACTTCTGAGGAGAGCTTCAGTTGTCTTTGCTACATTGTATGCATTAGAAGCG


AATTAGTAGTTCATTCCATATTTAGAGAACAGGGCTTAGAAGCGAATTACTAGTTCATTCCATATTCAGAGAACAGGGCTGGTTCAA


AGGTGTGTGACTACCTCCGGATGGAGGGACGACTAGCAACCATTCCAAAAGCTACAGAGTACACTGTGAAGACGAAGCTCACGGTGA


AGAAAAGGAAGAGAGAGAAACATAAAATCCAGGGTAATGATCACCCTGGGCAGTGGTGATGGAAGACTGTGGGAATAGCTGGTGGGG


GTGAGGGCCTGGGGTTGGACCCCTTTCTAGATGCTTATTATTTTCTTTTTATGTTTTATGTATTGGTTACTTTTAAAAAAATTATCC


CTGCAACAAAATGTCCAGCAAAAGCAACTTAAAGAGGGAAGGCTTTATTCTGGCTTGCAGTTTGGGAATGTAGTCCACTATGACCAG


GAAAACATAGAGATCAGGTATGAGACCACCATCACATTGTATCCTCAGGCAGGATGCAGAGACACTGTGCTGGCACTCAGCTCACTT


CCACTGGAGCCCAGCTGGTGAGGCAGCACCCTCATGTTCAGACCATGTTCTCATGGTCTTCCTTGTCAATTAAACATCTCAGAACTC


ATAGATACACACAGGGGTGGCTCCTTGCGATTTTAAACCCTGTTAAGTTTAAGCATTTTACATCATAGCAATTGTTATATGTATTTT


TTTCTTCTCCCTGAATTTGTTGTTGTTGCTGTTGTTTGCTTGTTTTTGAGATGAGGTCTCTATCCCAGACCTCATCTTGAACTTGCT


AAGTAGCTCATCTCTTGATCCTCCTGCTCTGACCCTTGAGGGCCGGGAACCCTAGGTGTGTGCCACACTTCAGTTATATCAGCGCTG


GTTTTAAGGCCATGGCTTTGTACATGTTAGGTGTCTTGGTTACTGTTCTATTGCTGTGAAGAGACACCATGACCAAGGCAACTTATA


AAAGATACTGTTTAATGGGGGCTTGCTTACCGTTTCAGAAGACTAGTCCATGCCTCTCACTGCAGGGAGTGTGGCAGCAGGCAGGTA


GCTATGGTACTGGAGGAATAACAGACAGCTTAAATCTTGTCTGAAAGATGGGGCCGAGAGAGGATGACTGTGCCGGATGTGGGCTTT


TGAAATCTTAAAGCCCACCCCCCAGTACCACTCCTTCTCCAGTGGGGCCATACTTCCTAATCCTTCCCCCCAAACAGTTCTAGCAGC


TGAGAACCAAGCACTCTGATCTATGAGCCTATGGAGTCCATTCTCATTGAAACCATAACACTAAGCAAGCACTCTACCAACTGAGCT


ATGTCCCCAGCCCTTTGGTTTGCTTTTATGTTTGATATGCATGGCTTCAAAAACCTTTAACATTTACTGATTTATCTGATTATTTAT


TATTTGATTTCTATTTTAGGGGTTTTTTTTGAGATGATATCTTGCTGTGTAGCCTCTGAACTCACTACAATCCTTCTGCCTCAGACC


CTTGTGTGCAGAGATTGCAGATATGTGCCTCAGATCTTCCTGCAGGCTTCCTGCAGAGACTCTAATGTCTGTGCAGCCCTAGCTCTC


CCTGCTTATCCGTTTCCGGAGGCATCTGACTCCCAAGCTTCTGCTGACGAACTCAGCACTTTCCTCCAGGTCCCTAAAAGTCATGCT


TGGAGTGTGCGCTTCTGGTGGCTTTGGTTTCAAGAACTGTCTGTTCACTAACCGTTGAAAGGTGAAATCTCGTTCCTTGCTTTCCCC


TCATCCCCTCAGCTCTTCCTGTTCCCAGTTGTTTTTTTAAAATAATAACTCTATATTATTTTGGCTAAATCAAAAATCAGTGTTTAC


GTTACTTAATCAAGACTAATTTGACTCTATTCATGGTCGGATCCCATGGTAAAATCCAATCATTTTCCCTCTCTTGCAGCCCTTTCA


TCTTCCCTAGAGTTGCTAATTATCACTTTTCTTCATTTGCTTAGGTTTCTGTGTACTTATCACTTGTTAACTCCAACCTTGCCGTTT


GTCAGAAGTTCAGGCCTCTTATACCTTTTTAAAAAATTGTCTTCCTAAAACTGGCCCTAGAGCCTCCAGCCTTCAGACTGGTGCCCT


GGTCTTTTCTCCTCTGCAGGACAGATTTCTCTAGCCCTGGTCTTCCTTCTCCTGGCCTTTGGAGAGCCCAACTCCACTGGGCTGTCT


AGTTTAATGTCAACTTGACACAAGCTAAAGTTATCTGAGAGGAGGGAATCTTAATTAAGAAAACACCTCCATAAGATCTGGCTGTAG


GGCATTTTCTTAATTTGTGATTGATGGGAAGGGCCCAGCCTGTGGGTGTTTCTGCCTCAGGGCTGGTGGTCCTGGGTTCTGTAAGAG


AGCAGGCTGAGCAAGCCATGATGAGCAAAGCAGTCAACGGCACTCCTCCATGGCCTCTGCATCAGCTCCTGCCCCCAGGTTCCTGCC


TTTGTGCATTTCTGCCCTCACTGCTTTTGACGCTGACTTGTTATATGAAACTGTGAGTGAAATGAGCCCTTTCGCTCCCAAGTGCTT


TGGGTCATGGTGTTTCATCACAGCAATAGTGACCCTAACTAAGACACTCACATGGCACCCTGGGGAAAACAAAGCTTCCGGACTGGT


GGTTCCCAACTTTCCTAATGCTTCCACCCTTCACTCCAGGTCCTCATATTGTGGGGACCCCCAACCATAAAACTATTTTGCTGTTAC


TTCATAATTGTAATTTTGCTACTGTTATGAGCTGTGATATAAATATCCCATATGCAAGATATTTAATATGAGATCCCCCATAAGGGT


CTCATACCCACAGGTTGAGAGCTGCTGTTCTAGAGCCTTGTGAATAGGGAAATACCCTTTACTCTGTCTCGTTCAGACTCAACTAAT


GCTTCGGCGCTGTCTTTGTTACATTTCCATTGCAGTAAGACACCATGAGGCAGGGAACTTACAGAAATGAGAGTTTATTGGGACTTA


CAGTTTCAGAAGATCCATAATCATATGGCAGGAAGAAGAGCAGCAGGCAGGCAGGCAGGCAGGCAGGCAGGCAGGCAGAGCACTGGA


GCAATGGTTGAGAGTGCATGCCTTGAGACACAATCACAGAACAGGGAGTGCTAACTGGAAAAGAACCTTTGAAACCTTAAACCTCAT


CCCCAATGACACACCTCCAACAAGGCCATACTTCTTCTCTTAGTTGGGGTTACTATCACTGTGATGAAACGCCATGACCAAAGCAAC


TTGGGAAAGAAAGGGTTTATTTAGTTTACACTTCCACATCACTGTTCATCACTGAAGGAAGCCAGAAGAGGAACTCAAACAGGACAG


GATCTGGGAGGCAGGAGCTGATGCAGAGGCTATGGAGGAGTGCTGCTTACTGGCTTGCTCTACATGGCTTGCTCAGTCTGCTTTCTT


ACTGAGCTAGGACCACCAGCCTGGGATGGCCACACCCACAATGGGCTGGCCCCTTCCACATAAATCACTAATTATGAAGATGTCCCA


CAGGCTTGATTACAGTCCAATCCCATGGAAGCATTTTCTCAATTGAAGCTTCCTCCCTCCTATCTGATGACTCCACCTTGCATGCAA


GTTGACAGAAAAACCATCCAGGACACTTCCTAATCCTTCCCAAACAGTTCCACCAGCTTCGTACAAGTCTTCAAATATCTGAGCCCA


TGAAGGAACACTCTCACTCAAACCATCACAGATGGTCTCTCCTGACCAGAATTCTGATTTGGAAATTATTTTCCTTTAGACTTCCTC


CTAGACTTTATTTTATGTGTATGAATCTTTTGCCTGCATGGATAGACATGCACCATGTGATGCCTGTGGAGACCAGAAGAGGGCCAT


CGGATCCCCAGGAGCTGGAGTTACAAACGGCTGTGAGCCACCATGTGGATTTTAGGAACTGAACCTGGGTTCTGTGCAAGAGCAACA


AGTGTGTCTAACCACTGAACCATCCCTCCAGCCTTGTTTTTCCTTTAGACTTTTGACAGATGTATCCCATGCCTGTCTAAGTTCCAT


GGTTTCTGGGGGAAGTCAAAAGTCATAATCAGTGATGTCTCTATTTGACTTTCACCCCCTCCTCTTCTACTATCTCCTGCTCATGGA


ACCCTGCAGCTCTCCTCCTCCTCAGTGGCACTGAAAACCTACATAGTCATGTGCCTCGCTGTGAGCCAGTCGCTGTCCATTGTGCGG


GGGACTTTGGTAGAAGCTCTCCGGATGCCTCTCCAGCCCCGCCCCACCAGTTCTTTCTCTCTGGAACTGATACTTGTATCTGTAGAC


AAACCTACCAGTTTCCTTGTATGTCACGTTCCTTTTTGTTCTTTCTGTTTTCTGCATTTGGGAGTCTGCTTGATTTCTCTTCCCGCT


CCGTCCAACTGACTTTCCCCGGCAGAGCGCCCCTTCTTTTTATTTTGTTGAAAATAGACTCTTCTGTCACACAGTACATCCTGGCTA


CAGGTTCCCCTCCCTCTGCTCCTGCTTCACAGGTGCGACATCTTATTTTATCTCCCTTGTGATGATAATTATAGATTCCCTCCTCAC


TCCCACGTCTGACTAGCCCTGCCCAATGGTTCTTTTCTGTGAATGATCTGTTCGATCGATCCCGATTCCGTTTCCTTTGNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNAGCCATGGTCCACCCTGAGGGGAAAAATTAACAA


TTATAATAGTATTCTTGAATTGAAAGAAAAACTTCCATCTTTTCTTCCTCAGCCCTTAGAGAAAAACATGAAACTACTTCCTCTCCA


AAATTCTTTATTGCAAAAAATAGCAGGAGATTAGTACGTGGATGTGTGACATGTGTAAACCACTTAAAGCTCTGACTAGGCTTCGAG


CTGCTCTCCCTCCCACAGCCCTGAATCACCAGCTGACTGCTCCTGCATCACTTCCTGTTGGTGAGTTGCAAGTGGGTCTCATCTCCA


TCACGGCTCTCCTGCCACAGCAGAGCAGTGGCTCCCAGCAGCAGAGCCAGGTCAATCAATGTCAGCTTCTCTGTCACCCCACAAGAG


GAGGGGGCAGTGGTGGGCACCTAGTGAATGGGTGGCTTTCTCAGGATATATCCTCTCCTTGTCACACAGCAAAGGCTGTTTTTGTCT


ATATATGTATATGTTCAAGGAAAAATTTTATTTTGTATTTTAGGCATATATATAGATAAATAGATAGATAGATAGATAGATAGATAG


ATAGATAGATAGAGAATGAAAAAAAGAAACCCACAAGAAAAATTTTTAAGAATCATTAAAAAAGCAGTTTTATATCATCTTTAAATG


CTTGCTTGCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGTTTGTTTTTTGAAACAGGGTTTCTCTGTATAGCTCTGGCT


GTCCTGGAACTCACTTTGTAGAGCAGACTGACCTCAAACTCAGAAATCTGCCTGCCTCTGCCTCCTGAGTGCTAGGACTAAAGGTGT


GCACCACCACACCCGGCTTGCTTGCTTGCTTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTTGA


GATAAAGTCTCTGTATCTGGCCCTGGCTGTCCTGCAAGTCACTATGTAGACCAGTCTAGCCTCCAACTCACAGAGACCTGTCTGCCT


CTGCATTCTAAGTGCTAAGATTAAAGCTGTGAACCATACCTAGCTTGCCCTGTATGTAATTCCCCCTTTGATCTCTAATCTCTGCAC


CTCAGAGTTCACAACCGTGAAAATGGTTGGTGTGATGCTGAGGCCAGGCACCCGCTCAAGAACACTAATGTAAGCTGCAAGGTTTGC


CAGGAAAGACCTGTGAGGTGCTGCAGGCACACGAAGCAACAACATGCACAGTACTGCACTGCCGCATACTAATCCCAGTCAGCGGGC


TGACACTCTACGGTGCCGGTGCCGGTGCCGTGCTGCTGCTCTGCGTGCACAGCAAAGGTGCTTCCTGCTGGGGCCCGACCTCTGTAT


GCTGTTGTCACCTCGGCACGCTCAGATGGCAAGCTTCTTGTCAGTGGCCTTGGAGCAGGCTCTTCTGTTCCCAGGTCAAGCACTTCA


GCCTAAACTTCAAGGCAGTCCTGTGAATGCCCTGCTATGCCTTTCCTCTGGTGTCATAAATCCTACCTTTTCTGTTTCTGCCCTTCC


CCGTACAGCCACTGCTGATATGTGCTAAATACTTACTGTGGGCTACAGACTTACACTGCTTGCTTGCTTGCTTGTTTGTTTTAATCT


TCCCATTAGCAGATAGGAAAACTGAGTCACAGAGGGATTTACATTACCTGTCCACAGCCACGGAGCACAGTGCAGCTGGCACGGACC


ACACCCAGATGTTGCTCATGCCTCCTGACTGAATCCCAGTATTCTTAGACCGGACCCAAGCTTCCCCTCCAGAAAATCCTCTTCCTG


ACTAGGCGCACTGGCTGTGTGCTACCGGCTGTGCCCCTGCAACGTTTGCTTCCGTGCTGCCGACTCATTGTGCAGGCTCTGTCCGTC


TGTCTGTCCTTCCCACTGCCACTGAGCCTTGCTAGGCCGCCAATCGCAGAGTCTGGTTTTGTAGTCTAGAGCCTGGGAGTCAGAGCT


TGTTGTCTCCTCCCAACATCCAGGAAAGAGCTACAGACCAAGGACAGGCAAGTGGGACAGTGGACAGATACCTGTCAGAGCAGGGCT


AAGGGTGGGAGAGTGGAACAGGATCTGGCTTGGTCCTGGAGGAAACAGTGGGGTGCTAAGCCTGAACCTCTCCAGGATGGCCATGGG


AACAGAACACGCCAGCCTGGGCACATGAACCTAGAAGAAGAAGCCAGCCAGGCTCCTAGCATGGCTGAGAATTGGATGACTGGGCGA


TTAAAACTATCTTCAACTGTCCCCAGAAGCTCCAGGCACCCAGTCCCTTGTACAGGCAGCAGTAAAAGCCACTGCCATGGTGATGAT


TTGGAACTGGATTTGAGGGCAGTAGGCAGTGGTGGCCATCTTGCCCCAGTTCCGCACTCTGCAGACCTAGCTTCCTTGCTGCTGTGC


CTCATCTTTTCAAGCATCCTGCTTGTTCTTCCTCTACCAGGGAACCCAGAGTTGCCTCCAAGCCCTCTAATGCCAAATGCAAACACC


TGCCCATAGAACCCCAGGCCCTCCAGCCTCTTCTGAGCACTGGTCTCCCAAGCTGCGTGTCCACTGCAGAAGCCCAGGTGACAGGTG


ACCGCCTCCCGTGGACACTTTCTCTCTGGGACACGTGCCAGTCTCTTCTGTTTCTCTGCTGTCCAGTGGAGCAGCAGAAGTCATGGG


CTTTGCATCAGTTGCTTCCTATGAATCACTCAGCATCTCTGTGCGTCTAGCCGCTTCCCCGTCAGGACTTGAAAGGCTGCCGTAAGA


AATAGAGTGTTTATGTTCAGAGCAGCGCCAGTAGATATAACCAGACAGCAGGTGCTCTGTAGATAAAATCCTTTGCACTGCCTTGGT


GTTCCTCAACTAGGTGCTTGTCAGTGACTAGCAGCTTTTCTGCTTCCTTCAGGGGCATCTCCAGATACACTTGTGCTTGCAGATAGC


CCTGCATGCCTCACTAGGAAGGTGGGTCTGGGGAAGCAGTGCTGGGTGATCACTCATGGGGTATCAGTCTCGGTGCATGGAGATTGC


AGCTCAGTATAGCTCGGGCTCAGTCCTTACGTATGCCATGTGTGTTAACAAGTGTCAGTCTCCTTGGTTACGACATTCCCAGAGAGC


TGCCCCCTTTACTCAAACAGGCTGGCTTGATCTCCCTGCCCCTGGCTCTCTTCCCCACTGTTTATCAGAAGTAGGATTGCACTGCAT


GCCACTCACGCTGGCCCAGTAAAATGACCCTTTGAGAAAGGACCTTCCTTCCTTGCCATCCCCACTCCCCTGCATGCTGAGTTTGGG


TTCCCAAGACCTCCTGGAGAACTGCAGCCCTGCCCCCACCTCAGTCCACGGTGCTACTGTCACAGAGCACCACAGACTGGGTAACGT


ACGAAGATGAAAAGGCTAGTTCCCATGGTTTTGGATACTAGGATGCCTTTTATCAAGGCATTGTCGAAACACCAATAAGTTTAGCGT


CTGGGAAGGCACCTGGTTGACACATCCTCCAGAGGGAAGGAAACTATGTCCTCATGTCTAGAAGGCTCAAGAGCAAAGCAGTAGACT


GGTACACAAAAACCCTTTTAAGTCAGGTGAAGGGACACGGGCCTGTAATCCTGTCACTTGTGAGATGGAGGAAGAAGGTCAGAAGTT


CAAGGCTAACAGCACATGAGAATGTCTTTTTTTTTTTTTTAAGGAATAAGTAAATAATAAAATAAAATAAAATAAAATAAAACAAAA


CGTTCCCAATTCATTCATGAGAGGATACTTCACAGCCTAATCATCTCTAAATGGCCATCTCCTATCATCTTGGGGACATCGGCTTTT


GAGGAGGGAAGACATTTGAGCAATGCCAGGCACCTTCAAGCTGAGTGTGGAGGTTCTTGCCTTTGATTCCAGCACTCAAGGAGGCAG


AAGCAAGGGGATCTCTGTGAGTTCAAGGTCAGCCTGATCTCCATAGCAAATTCCAGGCCAGCCAGAGCTACAGAGTGAGATCCATTC


CAGGAAAAAAAAAAAAAAAAAAAAAGGAGGCACCTGCCAGTGTCTCCTACAGAGCCCTCTGCAAATGTCTGTATATCCTCAGAGCAG


AGCCCCAGGGCCAGGTTCTCCCGAGGAAAGGAAGGAAATACAGAGCAAATGGCCTCCAGGCAGAGGAAATGAGATGATAGTTCTAGC


TGTGTTCTGCCACTAATGTTTGTCTGGGTCAGAAAGAGGCTGAGCCTTTGTGAACACTTCCGCGTTCCCCCACCTGTGAGGTCGGTT


TCAAGAGAGAGACCCAAGCTACAATGGCTTCCTTCTACATACACAGGAGATACCAGTCCTGAGAGAGAGAGAGAGAGAGAGAGAGAG


AGAGAGAGAGAGAGACAGAGAGAGAGATTGATCTTGTCCAGGAGTCTGTGATTTCAGATTAATCATATAGACGGTCGATTTAGAAAG


AAAATTAGAATATTATGCATGCATGACCTCAGCTGAAGCTGTCCTACCAACAGCAAAAGGAAGTCTACAACGCATCACAGATCGTGA


CAAAACATTTTTGCCTTTGGGACTCAGCGACTGCAGGCAGGCAGGACCTGGATGGGCTCTGATGCAGCCAGCACCTTCGGGAAGGCC


TAAAGAAAGGTGTCTCACTGACACCACTGTGTGTTCCTCAGTACCCCACCCCACCCCCCTAGACTGTTCCACAGTCTCTGTTCCCAG


GAATAGGAGTTTCACAGACTAACTCCCGTCTTCCCTCGGCAGGTACCATGATCAGCAGGATGTAACTAGTAACTTTCTGGGTGCCAT


GTGGCTCATCTCCATCACGTTCCTTTCCATTGGCTATGGGGACATGGTGCCCCACACATACTGTGGGAAAGGTGTCTGTCTTCTCAC


CGGCATCATGGTGAGTACCGCCTCTGCCCATGGTCCTGCCCTCCCAGAGGGGCCTTCCTGGGGAGGGGGAGGGGGAGGGGTGCTGGT


CACTAGGCACTCATGCCTCCCCTGTGCAAGTCGAGAGGCAAGTGTGAGTTGTGCAAATCTAGTTTCCAGAGCCCACCAGCTGGAGTT


GGCTGTCGCTCTGACCCTCTGCTCACCACTGGGGAACCTCAGGCTTATCATCTGCCATGCTCCTTTCTGTGTCCTGGATTCCATAGA


CCTCAGCACCAGTTCTGATCAGGTTTAGCTGGAGCTCAGAAATAGACCATTGAGCTGGCCTGAAGGGCCCTGGGTCCTGAATGGGCT


TGGCTTGCTGGCTTGAGTTCTGGTTTGTCCACATGGCTCTGGGACAACTCTTGGCTTTCCCAGGCTTTGTCTTCCACGCTTGCACAT


TGGATCGCTGGCTCTGAGTGACAAATGCTTTCCAGCATGGGTATCTGGTAAGACCAACAGGTCTGCAGGCACCCAGCACCAAGGTCT


GCTTCTTCCCACCCTCAGCCAAATGCCTCAGGCTCCAGGGAGCTGGGACACACGTGTTCCTACCTTTCGCTGGGCCGTGTGCGGCAT


ATGGGAGGGATGTGGTGTGCAAGTAAGACACAGGGCCCAACTTTTCACTATCCCTTCACTTTGGCCCCTGGGCCAGTCACTCAGCGG


TCACCTGTGGAGCCTACAATCTTTGGGTATAGCTAGATACTCAACTGGCCTCCTCACTGACTTGTGGGCCCCAAGATATAACTGATG


TGAACATTTTGGGTAAAGAGTGAGTACTGTATTCAAGCTAGCCCCACATTTGAAGCAATCAGGATTGGGGGATATTTTAGGGGTAGG


ATAGGGAGTGTCTACTATGATGTCCTATGTGGAGTCTTAGAATCAATGACAGACTTCCTTTTTAGCCCAGGGAGACCTGTTTCTTAG


AAGAGAAAAAAAAATCCTGGAGAGAGGGGCACACAGCTCTGCTGGGAGCCATTGAAGCTGATAATGGGGTGACAGTACAGATAGGAT


GTTTGAGGCCTGGTTCTAGGTCTCTCTCCACAGTCTGACCCCCAGATCTCTCAGTGCTGTCTTGCTCTGCACCCCGCCCAGCTGCTG


TGAAACCCCTTTCAGGGCTCCGTTCTCACTGCCCCCAAGAGATAGGACAGCCTTCCTGTGAGCCAGTGACTGGTGTCTACCGAAGGA


GCCAGTCGGCTGCTAGGTATAGAGGAGACCCCAGGGCGGTGGCTGGCTGACCACAGCCTCCTGTTCTTTCCAGCTCCCAAGCAGAGC


GGGCCCATGTCAGCAAGCAGCCTTGAAACAGCCGGTAGTGACAAGGGCATAGTGCCAGGCTGGGATAAATCACAGTAAGTGCAAGGC


TTTAGAACAAACACCTCCCATCGTTCAGTAGGAGTCTGTCTGGCACAGCGCCAACAGTCACCAGGAAACCAGGCAGAGTCTTCCTAC


CAGAAAGGAGTTAAATGCCACCTGAAGACTGTAGCTTTCCTTCTGAGACTCTTGGAGTGAGCTTCAGGCCCCACCCTAGTTCTCAGG


CAGGGTACTAGGAGCCTCCTTGCCAAGAGGTGCAAGAGCCTCTGTTATTTTTAAATGCCAGCCATTCTTCCTCTCAGAATGGAGCTG


TGCCCTATCCAAGAAGCTGCCTGGGCCCACTGTTTCCCTGGCTCCCCGGTTTCACATCTCCTGGCTTTGGCTCTAAAGCATTGGTAA


AAAGACAGGAGGCCCTGGTCTGAGACACTCCTTATCCGTAGCCAGTGGTCTGCGTTGGCCTCCCCAGCACCCTCTATGGCTGCCTGG


GATCCACGGTGTTGCTTGTGGTTTGTGGTGAGATTCAGGTGGAAAGAGCCACCAGGCAAGAGGCCACACTGCCCTCCTTAAATTCCA


ACACAGGCTTTTCCTGGGAGCGCTTGCCTAAGGCCTAGCTCCCCACAAAGGCTCCAGCATGGGACGGTCCCTTTGTTCTTTGTCAAT


GTCTTCACCCATATTAAATGCCACTCACTCTGGAAGCCTGGTGGCTTTTTGTTTTTCTTTTTCTCTTTCCTATTCAACAGGACTCCA


GCTGAGTCATTCCTTTCTAGGGGCTCACATTGCTAAGCCCACCCCCAACATGATGTATATCTCCTGATTATTATTCCAAGGGCCTTG


ACTAAAGGTAGGGCTTCCTGTTTGGTTGCCATGGACACCACCTAGGCCAAGGCAAGGGCTGCACAGGAAGGGAAAGGAAGGATTTTG


TGTGCCTGCTACAAATGGCCTTAATCATTGTTTTCCTTTGGCATCCAGCAACTGCATAATTATCCACCATTAGGCAGGGCATATAGC


TGTCTGGACAACTTGACACCGTTGGCTTAGGCCTGGAGCACTTGAGAGTTCACTCATTAATGCAAATCTACCTTGAGCCCCAGCACC


TTCCCATGAGGAATTTTCCAGGATACTTTACAAGGTAGTTACTATTCACCACCCAGAAGGAAAATGAAGCTTTTGGCTTAGCTTCTG


TGGGTATCTGGGAGAGCCTCTGGGCCCCCCAGAGACTTTCTGGTGGTAACTTCATGTCAGTGGCTCTCTCTGTGTCCCAGATTTGGA


TGCTCTCTGTCACCCTGATGCGGGTTGTAGACAAACAGGCCTTGTAGCCATCCATCCAGTGGAACAGTGAGCTTTCCCCAACCGGGT


CTCGAGAGATGCCTCTTGAGCTGATGAAGAAGAGGTGACACAAACCGAGTGACCTTGGGGGCAGCACAGATGGTCTCAGGAAGACAT


CTGCTTAGTGTCCTGTCCCATGCAGCTCTCCTCAACCGCTGGGGTTTCAGAGCTGCTGATGATATTTTGGCTGTCCCACAGAATCTA


TTGCAGCCCCGAGGCGACCGTAAATGTTCCTGGCTGCCTTCTTCCATGTGTCACGTTCATTTATGTTTTATCTCCTTTTATGCCTCT


TTAGTTAAGAACACCTCATACTTTTCCCCCTCGGGATACTTGTTTTTCCAACATCTAAGATTTTCCAGCTGGACATTTTTCTTGGAA


ACGGGAAGTGGGAGGCATGGTGTGGAGCGGTTGGTGTCCAGATTTGGGTGACGACTTAGACATGTTCACCCCTTTAGAAACCCCTTC


TCTGGGCAGTCTGTAGCCTCTGCTTACCTGTGTACCTTGGGCAGTCTGACTTTGTTGGAGGCAGGTCCTGCCCCGCTCTTTGCAAAG


AAGACTTGGGTGGAATGGACTGAAGATTCCCATCAATGTCAAGGGAGTCAGGTCTTAGCATCTAAAGTCAAGAGGCTGAGTCACAGA


TTTGCTCCCCATTTTAACCCCACAGAAGTCACTCCAGCAGCTGTCATCTTTCCTATCCCATCACCCCCCCTCCTCATGCCCCTCTGT


CCCCCTCTGTCTCCCTCTGTCCACCGGCCACCATCACTGCGTTTCCACACAAGGACAGCGTGAGCTCACATGCTGCACTTAAGCAGG


TCCCTGAGAGTCCATCCATTAGAGCAAGCTGCACAACGGCTGAATCTCACTAATGCGCCCGGGTGGCTAATACAACCCTGCGGTCAC


TCTCAGATACAAGACATTTCCAAGGGAACACAGAGTGGTCACCATCAAACCCATAGGGATAGACAGGCTGGCCATTGGGAAGGGGGC


CTCATGGCACTTCCTGGGTGTCCTCTAAAGACCTCAGATGGATCATTCGCTCTAACCCTGGCTCTTCACTCTTCCTTCTCACACCCA


ACTGTTGTTTGGTTGTTTCGTTGTTTCTTATCCCTGGCTTTCTCCTTCTGTTTTCTGATTAGTGCTGATTAGAATATGGCCAAGTTG


TTTTCTATCTCATTCTCCATTTCCCCTGCTCCCCCATCTTCTCAGTCATCCTCGAGAGGACCAGCAGCCTGGGCTGTAAACACCTCA


CACCATTTTCTGGGGGTTGTTGCTGCTTGATACCACATTCACAGAGTTGCCTCTTATACACATTAATAGCTCTGGCATCATCATCCG


TGATCTCCCTAATTACATCCAGTCATTGAATTATCTAAAAGAAAGCAAAGGGTGAAGGCTGGCAAGACGGCACATTGGCTAACGGCA


TACTGCCAAGCCGGATACCCTGAGCTCAATCCCCAGGACCCATAGGTACAAGGAAAGAACTGGCTTCTCTTCTGTTGTTCTCTGACC


CCCATGTTTGCACCCGTATACATACACATGCACACAGATAATTAAATCTAACAAATTTCTCATTAAGATTGTGCATACCCACTGAAG


TGGGAATGGCGTGAAGAAGGTAGCATCCTCAGAAGGGTATCTCTGAGGGAATGTTTACATTTTTAGGCTGAATAGAAACCGGGCTCT


GGGATTTAGTCTACTTTCTTGCCTCCATGCTGCCCCCTCAACCCCCAAAGTATCCTTCTCATGTAAGATGGGTATTTCCTTAGTTAA


GCACTGCCCTTCGCATTGGCAGTCCACTGTAGTCACAGCGTCAGCCAGCTAAGCTGTGGGCCAGGGCTGGAGCTGCAGGGCTCCCCT


CTAGACCCCAGCAATTGGGGCATGACCAATTGTTTTGATGATGTTCCCAAGATCCATATAGCAGAAGGGTGACTCGCTCTTCAGATG


TCACACCCGGCTTTCCGGGGTGATTTAAGTGGAATTATTTCTGGACCCAGGAGAGCCTGGGGAGAACCCTCTCCCTCTGATGTCCAT


TTTTAATGCTAGGACACATCCTTCTTTCTGGATGTTCTATACAAAGGAGATGGATGGCGCTGGCTTTGCTTGGGGGTGGGGTATCCT


CCCTCCAGGACAGTTTCTTTTAAGCTATTTTTGCTTTTGACAGGCTGGTTAAATTGATTACAGCTATAGACTGAGCTGTCCAATTGC


CCATATCCTCTAAAAATTGGGCACCAAGTCTCCAGCAAGTCCCAGATGCCAAGAAAATGCAGCCATCCCCAAATGGACAGGGGAAAT


GAGGCCAGAAAAGAAAAGTTCACAGACTGGGCTCTGCCCTCGGATTAGGTGGCCGAATGGGCAGAGCGTCCTTCTGCTGTGTTAATG


GGATCCGTGTGGAAAGCTGGGGAGAGGCAGTGCCACTTTCCACATCAGCATCCCACACAGGATGGCCTTCATCACAGAGAAGGGGGT


GTGTGAAATACATTTGCCCCAAGTTGGCTATAGATTGTAGCATTTCTGAGAAATATTCTCCTCATTTCTCACATGTAGTATAAAACC


CAGGAAGCCAAAACTGTTGCTGGTAGATTCCTTCATCCCAGCATCTCAAACTGCTAATCTGGGCTCCATGCTGGGCTTTGTGGCATG


GGGACTGGTTGCTAGAATTCCTAAGTCCTCTACCTTTCTCCAAAGTTGGTGATCAGGATGGCACCATACTCAGAGAGCAGTGGTCTG


TGAGGAGAGGCCAGGGATGGCTTCCATGGGCCACTAGAGAACCAGGTGAAGGGATTCTGTCTCCCTCCCTCAGGACTCGCAGGCCAC


CAAGCAGCACCAAGGAGTGTTTCTAAACATAGGCGTACACTGCTTTCTTGACCTTGCTCCCTGCTCCGACAATGACAGTTGGGTGGA


TAGCTGAAGGACTAGGCAGGAAAGGCAGCCTGCTTTTCTGTGGCTCAGCTCAGGCCTGCTGCTTTGCTCCTCCTCTGTGTTCCCCTG


AGGGAGTTGGGAGATGGGAGCTACCTGAGCAGACTGAGAACATGATTCTGGAAGGGCTGAGAGTGTTCTACTGGGTCACTTAAATCC


TGGCTGTCGGCAGAAGTGTTGTCCCCTTTAAAATGTACTTGAGGCTCCTTCTGAAAGCCTGTGCTGAGTCACAGCCTAGAGCCTCAA


GAAGAAAGACCCACACACAGGGCAGGCACAGCAGTCAGTGCCTATCCAAGTATCCCCCTGGGAGATACTCATCCCAAAGATGGCCAT


ATACCCAAAGATGGCCATATTCATCTTTGGGGAAAAGTTATCTGCTCTTCATTTGGCTGTTCTCGGGACTCTCTCAACTGCCCGGTG


TGGGCTACACACTGCAGTCTGCACATGGGTTTTCCCCCTGGGCCTGTGGATGTGAGCTTGGGACGAATGAGACAAAGCAGACGTGGC


CTCCAGGTGCTGGACTGTCTGTCACTTGCCACACTGCAAGGGGCCTGATTACCCTAGGGTTTCCCTCCGGGAAGGCTCATTCTAGCC


ACACAGCACTGAGAACTTGAAGAATCAACTCCCACAGGTCAGCCAGGGTCACAAGGCAAGAAGCATTGCAGACCCCCTCTTTCATGG


GGCTATTGGGGCGCAAGCAGGTTTTGACAAGCTTTATGGCATGTCTTGACCAATTAGAGACTCAAAGTCTTATACCATTCCCTTGAA


ATGCCAACACTAAGCCTGGGGCACACCAAGTCTTGTGTTTTACCTCCTAACTGTGTGTTTTCTCTCCTGGGACCCTCTGACGTCCTC


TGGCAGGGTGCAGGCTGCACTGCCCTTGTGGTAGCTGTGGTTGCCCGAAAGCTCGAACTCACCAAAGCAGAGAAGCATGTGCACAAC


TTCATGATGGACACTCAGCTCACCAAACGGGTAAGCCACCTCACACCCATGCCTTCATGCAGGTCCACAGCCGAAGTGGGAGCTGAT


CAGAAAAAGATCAGACACCGGGTGTGGCTTAGCAATGCTCCTTTGAGTGCAGGTTAGGAGCATGCAGCTCAGGCGCACAGCCCCTAC


TGATGCACTACCCAATGCCCCTACTGAGTGCATGAATCTCAACAAACCAGGTGAGTCACCACATGCTTCCAGCAACCAGATAATTTT


CCTGATAATTAGATCAATAGCACACAGTGATAGAAGCCGTCTCGCCTCCCTGCCTGATGGGGTCAAATCAACCACACAGGATGATGC


TATATTTTTGACTATGCTCAAATATTTTCATGATTCTCATTAAGGCCAGTAGAGAGCCTTAAAATTATACTGGAGTTGTACCTAAAT


CCAATCCCTTTAAAAAGTCATTTAAAGAGATTATTCCAGTAGAGCCCACATTCCCAAATATTGTTGCTCACCAAAACGCCACCATCC


GTTTTCCCCTTTTGGGCTGTCTGGATAATGGCTCTCACTTGCATCCTTATGAACTCAGCTTAGGAAGAGGATAAACTCAAAGTGCAG


GGATGGGGTGATTAGCTGCTGCTCAGATTCCCCCACTGAATTGTCAGAGAGAAGGAAGCTCATTTCAGCCAGGCACAGTGATCCCAC


AACGCAAAAGGCTAAAGCAGGAGGATTGCCATAAATATGAAGCCAGCCTGGGCCATCTAGCAACTCCTGTCTTTAAAAAAAAAATTA


ATAAGCTCCTCTAAGAACAGAAAAGAATAAGGCTTCCAGGACAACAACAGGCCCAACAAACTAGGTAGGAGCTATTTCTTTAAGGAC


GGTTTTCAAGCGAGACTCTGGAAACAAATGGGAGCCTGAAGGAAGGTCAGATGTATGCCCTCCTGGGTGGCTGATCTTCTCTAGAGG


AAGAACCAGGACTCTGGGCGCTAACTGGGCATTGATCCCCAGAGAAACGCTTCAAGGTGACATGAATCTACCAGCAAACCCCACAGT


CTTAGTTGGGGATTTGAGTACTAGAGAAACTCTTCTGTGATTAACGTTTCAAAGCCATAAAAAATGTGTTAGAAATAGAGACAGGCG


GGAAGACAGAACAAAAAGAGACTGGGAAGGAGCAGGCGGGCCCTCGGGGAAGCCAGCACAGAGTTTGCGGTTGCCAAGGCCTCTCAG


CGCCTCAGCAGAATTATTTATGGCGTTTGATTGTTGGGTCTTTGATTGGGGGTTTCTTTAAAGAGCTGCCACAGATATAAAAAAGGA


ACCTGTACAAGCAAATCTTGACATATCATTGGCATACAGACCACAAGGAGCATCATGGCCCCGAGCCACCAGCCAAACAAAAGAAAA


CAGAGCTCAGGCATGACAGTATGTGACACTGTCACCCTGCAGCAACCATACCAAATGCTAGGAGGACAGCCTCAGCCTCAGCCTCAG


CCTCAGCCTCAGCCTCAACCTCCTCTCTAAGCCAGCCTCAGTCAGCCTCAGCATGGAGGGGAAGGCTAGGGTATGGGCAGTCGAAAA


TGCAAGTGTCATCCGGAGTCTACTCAGCTCACTGCTTTGAAACCCCACCGGCAAGGGGAGAGGGGTTTGTCTCCCAGATCTTTTCTG


AGGCTGTTTGCCAAGAACAGAAACAGTAACATTCCCTGTTTGCTCCCGTGGCGTTTTAGAGCCAAGAGTATACTTTGTATTTTCTTT


CTATTCCTTTGTCCTACCCCTTTTCCACCCAGTAAATCAGATACAAGAGGAAAATAAAATGAGGAAAGCCCGCTCTCTCAGCGGCTA


GGGAAATTAGCACACACACACACATACCCCGCACTATAATTGTAGAAGGAGATGAGCTTGTGGTTGTTAATTTCAATCTTTCAAAAA


TAATTCACTAAAATCCTCTTCAAGGCCACTTACTTTTGGAGGAATAGGGCTGAAAATCAAATCCATGGATATTTATTGCTTGCCTGT


GATGTGAGGTGCCTACTTAATTCAATAACATCTCACTTTTCTCCGAACACTCAAATCTGCTGAAATGTCCCGGTAATATCTTATATC


TTTTCCCAGGGAAATAAACACAAAAGGAATGATTCTCACAGAGGGAGATTGACAGCTGGCATGACAGAAATGTTACAAAGGACCTTC


TGGGCATCCTTGTCTGAACTGAAGCTGGCTCCGACCTCTGTGACCACTAGGGAAGCCTGTTCTTTGCCCTTTCCATATAGCCCATGC


ATCCAGTTAAGGTGACTCACAGGTCAAAGGCTGTTCCCAAGACTCCAGTGAATTCTCAGAGCAGGGTCCAGCGTGGAAGGAGTTGGT


AGTAGACGATTAGTGGCTTCCCCTGATGAAAGCAGATCCTTGCAAGAACAGGCAATATTAATCCCTTGAATATCTAAGCAGAAAGAA


AACATGAATTGTAGTCTGTGAATCACACAAATGGGAGTCATTCTGACATTAATTCATCCGGCCTGTCTAGCTTCCACCCAGTCCTTC


CAGGTAGCACCGGCTGTTGGCTTGTGTTTACTTGTGGAGAACGGAGGCAGCCTGGTAGCAATGGAAATGGACTCCTGACTTTCCCAA


ACTCCTGGCATGTCTCCTTTCACCTGAATAACTTGTCAACCTTGGTGGCAACGTCACTTCTGTACTTGGTGGGATCACAGCTTCCCA


CACTGACTTCGCAGTCACTGCCACTGTTAATCTATAATTATAACTTATTGCCAGCCCTGGACTACTCAATAATGTCTAAGGAAGTGA


CACATAGCAACGCTGTGCATGATCGAGAGATGACCCGTGTATCCCACCGACTCCCCACTCAGACCTGTGGTAGGCTCTCCAATCAAT


TTGATAAGTGTGTGCTGTTGGCTGGGGTGGCCTCTCTCTCCTTGCAGAAGGGTTCCTCGACCCCATGATCTCATCGAACCACATTTC


CCATGAAGTCAGTGCATAAAGCCAAACCCAGCAGCCCTGAACTACTTTAGGCTCCTGACTCTCCAGGGCTGCTTACATACGTCACTG


TCCCTTCACAGTCCAGGCCCAAAGACAGTGCCAGTTCAAGCTAGTCTGTACCTAGCAGTGCTCAGGGCCCCGCCCCTCACTCAGTTG


TTTACATGTGATGATCTCTCCAAGGCTCCTCCTGCCCCATCCTTAAAGCACCCTCCACCTGGGTTTTCTTGCCATAGACCTAATTAT


CCTGCATCTGCTCGTGGTCTTCCCAGTCATCCCTTTTCATCCCCCTAGACCTGATTCCACCCTGAACATACACATTCAAAAAACCTC


AGGCAGCCCGAGAACCTACTGAACAGTCCTAAATAAAACCTGAACTCTTAGAAAATGTCAAAGGCTTGAGGGAAAATGTTTCCACCA


GGCTTATTCAAAGACTTAATCTTAGCAGGGGTGTTTTATAGGGGACATAATGGCAGTGGCTGTTATGCAGACATGGAAGGCTGGCTA


AGGACCTCTAGGTGGATGGCCCATGGCTGGCATGGCTCATGAGTAGGTCCCCAGAAGAAGCGTTTCATTAGGTAATCAAGCATGCCA


GGACTAGATATGCTAATTCTCCCAGAAAAGGATTGCAAATGACATTCCCCACAAAGGCTGTGACCCAGAGAGACTGGGCACAGTGTT


TCTTTCCCCCACAATAATAGAAAAGCATAGAAACAAACAGGAAAGATCCTGGGGATGAGCTGGTCCAAACCAGATATGAATACTCAA


GTCCAGAGAGGGGGAGGGGGTGGATGCCCAACACGTGCACCTAGTTGGTGCCTGTGGAGGATCTGGTTTGCACACAGGAAGCATTAG


CACCCCAGTCACTACCCAGCATGGTTAGTTCCTTGAGCTTTGCATGATGGTTAAGGTCCCAGGCCTGCAAGACGAAAGAGCCAGCTT


GACTCCAATAGCCCAGTGTTACATCAATAGCACGGTGAGTAACCTGCCATTCATCACCGAGTTGCTATGGATAGAGCTCAAACTCCA


ACCCTGAACCACAGACTACATCTCCTTTCTGCTCCTCTCCCCATTCCAAAGTCCTGACAAGAATGTTGATGAAGCAAGCCCCTTGCA


GGTGAGGCAGTGAGCGTGGGTTATGATGGAGGAAGGAAGAGGGGAGGCAAAGCAGGTCGATGAGAGAGGGTCTTAGGAAATTGTCCC


TGGAGGAAAATGAGGAGAGAATGGCTGGCAGGAGGGGAGGGCGCACTGCTGTTTACAACAGACACCTCCAACCAAGCTCTGGAGACA


GGCTGCCTCCATTCACGGTCTCCCTCCATGATGTTCCTCATCCCTGCTCATTGGACTCCACCTATTGACTGTTGAGATGGTGACTCA


TGGCTGCCAGGCTGCTCTGGATTCCCTCTTTGCCCTCTCCAACCAAGAAGGACACTGCTCCCTCGGCGGAGAGGTGGCCAGAGCAGC


CTGTCGCATGCGATGCTGTGGTCAAGAATGCAGGGAACAGACACGTGTCCTTCTGCATACTTTCTTCTCTCGGGGAGGCTAGGGCCA


TGAGAAGAAGCTGACATGAATTGGAAAAGTGCTATCAATAACTTTTCGTAGGTCTACGAGATGGCTCGGTGGGAAAAGGCTCTTCCC


GCCAAGCCTGTTGACCTAAGTGTAATGAGCCCTGGGACCCACATGGAAGAAGGAAAGAATTGACTCTTGAACGGTATCCTCTAACTT


CTACCCATACACTGGGATGCATATACCATCCCATAATAAACAGATAAATGTAATGAGAAATATATGTTTACAAAAACAACACCAAAG


TAACTGTGCCTTGAAACACACCATGGGTGGTAAATAGAATGCTGAACAGTCTACCTGTGCTCTCATCTAATCAACACAGAAGCCCGT


CTCCAAGATGAATGACACTTGCAAGACCCTAACCCTCTGCCTGCTCTAATTTTCTTTGAAGCTCTTAGAATCTGATACTGTGGTTTT


TAACTTCGTACTTTCTCACCCAAAGATTACAAATTCTGTGACAGCAGCAATGGCATCGGTTCACCAAGAGTGGTAGCATGCACTGTA


ATCCCCAAAAGCTGCCACAGAAGGATTTTGTGTTTGAAGTCAATCTGGGCTAATAGTGAGTTCAAGGTTGGTCTAGACAACAGAGTG


AGACCAGGTTTTTTTGTTTTTAAAGATAACATTATTGATTTGTTGAACTCTGTCCTCTCCCTTTCTAGAACAGTGTCTGGCTCATCA


TAGGTCCTCGTTAGTATTTATTAACTATCCTTCAAATGGAGAGAGGACGAGAGTCTCAGGTAGCTCAGCAATAGATCCATGGAGGAT


CCACCCACTTACCACCTTTACCTGGAGGTTAATCCATGAAACGATGCAGACAGTCGTGCTCTGCAAAGCTTGGCACAGCAGTTAACT


CACAGTTATTTGGGAGATTTTCCTCAGACTTGGTTCTTCCCTAGTCCCACTAATGTGCAGAGTCTGTCCTTCCTAGCCAGGAAAGGT


AGTGTGCTTGTTTAATCCCAGTGCTCAGAAGGCAGAGGCAGGTGGATCTCTGTGAGTTTGAGGTCAACCTGGTCTACATATCAAGAT


CCAGAACTTCCATGATTGTGTGGTAAGACTCTGTCTCAAAACAAAACAGTCTCATTGTATATAGTATAAGGTATATGGTATATGGCA


TATGGTATAAGGTATAAAGTATTTAATATATGGTATATAGTATGTAGTATATGGCATGTGATATATCGCATGTGGTATATAGAATAT


ACAACTTAAAGTGAAAAGAGCAATGTGGGGATTAGAGAGTTTATAGACTCAGTGAACACCATCAGCCTCAGTTCTTATGCATCTGGA


AGCCAGAGAACTAACCATTCACACATAAAAGATCCCACCCAGCTATCTTCAGTGGCACCTCAACCCAACCAGTCAGAGCCAACCTTG


AATGGTCCTTGCCAGTTCGCTGCTTCCCTCTCAAGCCCTGACCCTCCCAACCCTGCATCCTGGGAACATCTTTTAGGTGTGGTATCT


TTGTTCATCAGGAGAGCTCAGAAGGTAGCTAAGCCTTCATCAGGGAAGGGTGTCTCACACTGTGGAGGCTGAGCAGGCCCCAAGAGG


GGCTGAAATGGTGCTGTCTTTTCAACCATGCTCAGAGCCTGGCACCAGGTGAGATGGAGGGAAACTCAAGAGAGCCAAGTGCAGTTA


AAAGTCTATTGCTTTTTCTGTTGCAGATATCGATCAACTTAGCTTTGTGCCAGGCCGTTTGCTAGCAATTAATTTCAGTCAGTCCAA


GGGCTTGAGTTTACCATTATTTTCCCGAATGCTCAGGGGCCTCCCTCTCAAACCCATAAAGATGATGTGATTCCGCTCTGCTCCCTG


GCCAAACCATGACTTCAGGATCTTTCATTTAGGCTGGCTGAAGGCAAGACTTGAAGTCTGTATTCTGTCATGTTGCTGAATGAGGGC


CAGATGCCTTAAAAAAGAAAGACAAAAACCAAACCAATGTCCTTCTCAATTCCTTGATCCTGGGAAAGAGGAAATGATTCTGTTTGT


TCAGATGTGATCCAGACCTGTCTTCCTTCAGACCATGTGGGAATTGTTTGCACCTCTTGGACCTGACTCTTGCTTAGACTTAGCCAT


TAGCTCTCTGTATGAGTCTGGCCTTTTATCCTCTTTCTGAAACTGTTTTCTTCTATTTTAAGTGGGGATAATAATAACCAATATCTG


TCTGATACTTTAAAATTTATATAGTGCTCAAATCCACACTGACTGTTTGCTATTGGCAAGCTGATGGGCTGAGGCTATGAAAAACCA


AAATGATGTTAGCCCGACATGATAGTGGGTTTGTGAGGCTGTCAGCCAGACCTGGATGGGGGAGCCTTGCTAAAACCAGCTATTCCC


TCCACACATCAGCTGTGCCTCACAAATGTGTGTGTCTATGTATGTGCCCAAGCATGTACATGTGTGTATGTATGTGTACCCAAGCTT


GTGCCCATGTATGCATTTGTGTGCATGTGTGCATGCCTGAGCATCTATGTATGTATGTATGTATGTATGTATGTATGTATGTATGTA


TTCCTATGTGTACCTGAGTGTGTGTGCCTGAGTGTATGTGCCTTAGTGTGTGCATGTGTGTGTGTCTGAGCATGTATTTGTCTTTAC


ATGTATGTGTGTACATGAGCTTGTATGCCTGTGTGCATGTGTTTGTGTACCTGAGCATGTGTGTATAGTGTGTGTGCATATATGCAC


GTGAATATGCCTGTGCCTGCATATGTGTGTGCATGTTTGTGTGTGCATTAGCCTAAAATGTCTTCCATTCACATTAAAGATAATTAA


GCATTTGCTTCTAAACTGCTTAATGATGCATACAGCCTATAGGCTTCCTCATTTCAAATGTTTGTTAGCAAGACACAGAGAGCATTG


TCAAAGGTTTGTCAGTTTGGCTATTCTGTGGCACTATCCACACTCCTAAGAAGGGACTGTATAGCTAGGGCTCTACCCGTCCTTGAA


ACCACTTGGGCAGACTTTGCCCTCTCCTGCTTGTCTTTAAGGCTTCCCTTGAAGGCCGAGCAGCCACAGAAACTGAAGAGGTCCTAC


ATCAAATTGCCCACCCCCTTAAGGGACAACAGCAGCATTCTGCTGAGAGAAAGCCCTCCCTTCCCCACCACCTACTTAGCTAACCAG


ATCCAAGGCCCAGAGCCCATCATCTGCTTGCCCTCCCTTGGTAGCCAGACACTGGCTACCTCCAGCCTCGTCTTACTGCCACCTGCT


CCCTGTCAAACAAGAAAGTGGCAGAGTGGCCAATGTAACCACTTAAAACCATTTCACAGTAGATTTTTTCCTGAACAACAACAAAAA


AGTAATATTTATGTCACTTAGACATTTCTGAAAAGACTTAAGATGTTCTTTTAAAAACATCACATCGACGCCAATGAAGAATACAGC


CCAGCTTTAGTAATAGATTTTGAAATACATACAAGTTATCAGTCTGCAAAGCAGTGTTTCTTAGGCCTTCCCACGTGTCTCAGCATG


TTAGCAACGCCCCCATCTGTTGGTGTCAGTCTCAGAAGCTGATTTGTAGTCTCTGATTTTATTAAAATCCTATCTGGCAAGTCACTT


GATCTCTTCTAGTCTGGTCTCCTCACTTCCATGCCCTGGGCCTGGGGTCCTGTGCCAGTGTGTATAGCTGACAGAAATGGAGACCAT


TAATCAGAAATACATTTAGCTTGTGCTTAATAAGGAGTATTTTCTCTTGTTCTCGCTAGTAATTGCTGAAGATGTCTGTGTTTGGAT


TAAAACTTTGTCCCCTGCCATCTGGATGCCATTGATACGTCTCAGCTCAGTCATGAGCTGGATGATATCAGTGGTTTCCATGTCAAC


AGATGACAAGAGTTGTGTATGGAGCCGTGTGACTACCGTGCCTGGGGAAGCCAGCCCCGGGAAGGAGGCAGCTGTGCTGTCACACCT


AAGCATCTTCCCTGATCTCAGACACCACTGAGATGATTTCAGTTTTGTGCCAATTACATTTACATGTGAAATCGCAACGCATAATTT


TTGGCCAGTTAGGAAAGGAACAGTGGTCTTGTTGGTACCTGTCATTGCAGTTTGTAAGAAAGACACTTTCTCAAAGACACCTTTTAA


AATCTCCACTTGGTAGGAAACCTATTACTTTCAAGTAAAGTGTGGTACCCTGATTATGAGGGCATTGACAGCATGTATTTATTGATC


CAAACTGTACCCCAGACTTCAAGAGCTTGCTAAGCAGCCTGTCTAAATATAGCATCATCAGCGGCAGCCGAGAGGCAGCAATGAAAC


CATTAAGAAGGAGGAGAAGTGCCTCTCGGCTCGAAGCTCCAGTCTAGGCCTCAGATACAAGATTAATAAAAAATGTGTTTTAATCAT


CTTTTCTAAGAGTTTCCTGATCTTGATTAAGAAAGTACATCTCTGAAGAACCATTTTCTCAGGAAGTAGATGGTAGCCACACATGCA


AGGAAAAAACATATTGTGTGAACCCAAAAATTAACCCAACAGCTGCTTGTTACCTTTCCCTCAGATCAAGAATGCCGCCGCCAATGT


CCTCCGGGAAACGTGGCTAATCTATAAACATACAAAGCTGCTAAAGAAGATTGACCATGCCAAAGTCAGGAAACACCAGAGGAAGTT


CCTCCAAGCTATCCACCAGTGAGTATCGGAGAACCAGAGCAGTGTACTGTTTGGTCAAANNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTCTCTTCTTGAAAATCAGCACCGTGGGCAGAACTAAGCGTGGG


TAGTCTGACCAGGAGGGCTCCCTGCCCCCCACTACCTTCTGATAGAAATTATACAGCAAATGCATAGCCCAGGGCTGGGCTGGCAGA


ACATTCCAGCAGATGTCAATTGTAACGGAACCTTATTCCCTGGGAAAGCAAAGGAAACTCCCTCGGGCCAATTAGGCCCCCTTTGAA


AAGAGCCTGCAAGCAGAAATTATTGGTTGCTGGGCCACGTGCAGGCTCCTCATTCAATAGAGGGATCAAGAAGGCAAAGAAAGAACT


TCCTATGGCAGTGAGGACCTCTGTCACAGCTAGGGAGACGCCCACAGACACATGTGCCATTGGAAGGGGCATTCAGGTGGAGTGTGG


GGTTTCCCAGAACCCAGTGTGGGAGTGGATGAATGGACCTCTGGAGTCTTAGGCATGTTGGTTAATACACAGAGTTCCAGCAAACCT


ACTGGAAGTACTCCCCATATGTTAGAACCACTTATTCCCAGGAGATAAGGGGGTGTCTGGAGACACGTATGCGCCACCTCCCCTCTC


CTGCTCAGGTGCTGTTCCCCCACGCCAACCTTCACCTCAACCCCCACCGCACCCCAGGTCACCTTGGGGCATATTTGACTTTCATTT


GTTCTTAATTCTAAATTCTTGAGAGAGGTGATTTGATTGGCTGGTTTTACTGACGTGTCTGTCTTTAGACAACTCAGCTATGACTAG


GAAGAAGGAAACAGCTAGGACAGGACTCTGTGAGCCTCAGCAGTGGCTCAGTGAGATGCCCCAGGCAATGTTTCCCATCTCACCCAC


AGGGCACACTGTGGCTGATGCTCCTCCAGCAATATTAGGTTAATCTAGGTTTTGAGTTCATCTTCCTGCAGGGCTGCCCACAGTTTC


TCATTGACGGAGTGAAAGCAATGGCTTGGTAGACTTGGAACACTTGCTGGCAGAGAAAGAGGATCTAAATTTGAATGCCCAACACTC


AGAGCTGCATGTGCCTTCAGCACTGGTGGGCAGAAAAAAAAAATGAAGTTTGATGGCCAGTGAGCTTGGCCAAGACAGCAGTTCCTA


GTTCAGTGAGAGGCCCTGTCTCAAAGGAATAAGACAGAGAATAATAGAGAAAGAGACTCCATATCCTCTGGGCTTTCACATGCTTGT


ACCTATGAACTGGCACCCACAGATTCACATGAAATACACACACAGACACACACACACACACACACACACACACAGAGAGAGACAGAG


AGAGAGAGAGAGAGAGAGAGAGACTCCTGCACTGGACTGGGAAATAAAGCCATATATCACAGAGGAATGAAGTCTGTGGGAAGAGAG


TGTGCACAGAGCCATTGTAAAGTCCATGCGTGAAACCGGAGGAGGAGGCAGACCCTGCTAACCATCCATTTAGTCCTCCCATGAGAC


CCAGATTCCAGTGGCAGTCACGTGTGCTTCGGTGTAGGTCCCCGCTCCCTTAGCATCCTGTTAGCATTGCGAAGGGAAAGCATCCAT


CGTAATGCTATGCTGGCTCCTTTTCCCGCCGTGCTTTGCCTCCCATCTCCCCGCCCCTCGCCTCTGTTCTTTGCTCCTCCCTAGATT


AAGAATGTACCCGTCCACTGCATGTTCTGTATTAGACAGGCCTCATGTCATGTATGCTGTCAGAGCTGGGAGGGCTGGGGCCCCTCA


CCCAATTCCTTCAGTTTCTTCAACTGGGAAATAAAAACAGTTCCCACCATCTGAAACTTGGGTGGTCAGATAAGAACTGTAAACCTG


CTTTGTGAGCTGTAAACGTTTCAAAAATGGCAGTTCTGATTAGGAACACAGATAAGGAAGGAACCAGAACCTAAAGGAACAAGATGG


CCACCACCTGGTTCCACACTGGAGTTCACCAGGTGCTCTTGTGGCCCAGCATGGGATCCGTGGCTTGTCCATTCCGGAGGGACCATG


CCCTGTGAGGAGGCACTTGACCACCCCCACCCCCATCCAGGTTACCCTTTCCCTGGGAGGGCAGAGCTGACAAGAGAAGAGCTGTCT


TCAGACCTGCTCCTCCAAAATTCCAACTGCAGGGGGCTCTCCTGCAGTTTCACCATGGCTCCTCTGCTGCTGCCTCACGTTCTGTTC


TCCTCCCTTGTCCTCTGTTCCTCTCTCATCCTGTTGCCTGCTCCTTCCACACATCCTAGAGCAGTGGTTCTCAGCCTTCCTAATGCG


GTGAGCCCTGAATACAGTTGCTCATTTGAGGTAACCCTAACCACAGAATGATTTCATCTCAGCCTCATAACTGTAATTTTGTTCTTG


TTATGTATGAATCGTCATGCAGGATATCTGATATGCCAGCCCCAAAGGGGTCTTGACCCATAAGTTGAGAACTGCTGTCCTAGAGAA


ATGCCAGGTCAGATGAGATTAGGGTAATTTCATACACACACCACACCACACCACACACACACCACACCACACCACACACACACCACA


CCACACCACATGGGCACGGGCATCAGAACCCCCTTTCCTCTCTCTGGGTGTGAGACTTGAGAGCCACCATTCCCGGTGCTTGTTGAT


TGTCTGCCGTGTATAGTCTAGGCTTCTGCAATCAGCATAGGAATCACGGGGTGTCTGTGCAGGGAGCTCTGATAACAAGTGGGACCC


AAGAGCAGTGTGTGACAGTGTTGGAGACAGGAGGCCATCAGGAGCACCCTCAATGCAGCCTTTGCCAGGCAGCATGGGAGGCGGGCC


TGCTCTGAGGAGTCAAGTGTCGTCTGCCCAACCAAAACCTCAGCCAGGTCAGACAGCCCTTAAAAGAAGCAACCTGCTCCAGGGCTT


CTCTACCTCCTCTGGAGCCAAGGAGCAGACGGGTGGCTCGTCAGCAGGGCAACCCCTTGTGGTCCAGGATCATGCCTGAGGCATTAA


TGACATTTTATATTCTGACTGCTGCATAGAAAGGGGGTGGGGATGCAATCTCATAACTATGTGTAGTTATTAACTCTGATTTTATAA


GGAGGTCAGGGTAGGAGAGGTTAAGTGGCCTACTAGTGAGCTGAACTTGCACTTGAACCTTGACTTGTTAATTAGGAGTCTACAGCC


TTGGCCATTCTCACCTCAGTGTCTCCTCTTGAATCATTAGACGGCAGCACTCTGTGTGAATTGACAACCATGTAGAGCCATATTCAA


TTTAAGAAAGGGACGTGTTTCTTTTCTTCCATGCATATTTTTTATTTAAAATAGATAACTAAATTGGGCGTGGTGATGTATATCCTT


AGTCCCCAGCACTCAGAAAGCAGAAACAGATCTCGGTGAGTTCAAGGCCAGCTGGGTCTACAATACTGAGTTCCAGGACACCCACAA


GTATGTAGTGAAACCCTGTATCAAAAGAACAAAACAAAACAAATTATAAAATTGATCCTCGATATCCATTCCTTTTAGAAAAAAAAA


GGGGTGCCCACCCCAGCCTGTCCATCACCTGGGAAGTCCTGGAATTCTCCTTTGGTGACACGGGAGGAAGCTGGGCGGAGGTGGCTC


CAGCTGCAGGGTGGAGGGCATTTCATCTTCCCACAACAGAGTCCTCTGTGGTGATGGTCTTCTTCCTGCCTCCCCCTCTGTCTCTCC


CAGATGCAGAACGTCATGTATGACTTAATCACGGAGCTCAATGACCGGAGTGAAGATCTAGAAAAGCAGATTGGCAGCCTGGAGTCC


AAGCTGGAGCACCTCACAGCCAGTTTCAATTCCCTGCCCCTGCTCATCGCAGATACCCTGCGCCAGCAGCAGCAGCAGCTGCTCACT


GCCTTCGTGGAGGCCCGGGGCATCAGTGTGGCCGTGGGAACTAGCCACGCCCCTCCCTCTGACAGCCCTATCGGGATCAGCTCCACC


TCTTTCCCAACCCCATACACAAGTTCAAGCAGTTGCTAAATAAAACTCCCCACTCCAGAAGCATTACCCATAGGTCTTAAGATGCAA


ATCAACTCTCTCCTGGTCGCTTTGCTGTCAAGGAAGTTGCAGACCAGGGAACAGAACGAAGAGAGA





MOUSE mRNA SEQUENCE:mR27-009.1 (Seq ID No: 24)


GCTTTGGGGTGGAGGGTCGTGCTGCAGGGAACTCAGCCAGGCCCCAAGATGGACACTTCTGGGCACTTCCATGACTCGGGGGTGGGG


GACCTGGATGAAGACCCCAAGTGTCCCTGTCCATCTTCTGGGGACGAGCAACAGCAGCAGCAGCAACCGCCACCACCGCCAGCGCCA


CCAGCAGTCCCCCAGCAGCCTCCGGGACCCTTGCTGCAGCCTCAGCCTCCGCAGCCTCAGCAGCAACAGTCGCAGCAGCAGCAGCAG


CAGCAGTCGCAGCAGCAGCAGCAGCAGGCTCCACTGCACCCCCTGCCTCAGCTTGCCCAACTCCAGAGCCAGCTTGTCCATCCTGGT


CTGTTGCACTCTTCTCCCACGGCGTTCAGGGCCCCCACTTCAGCCAACTCTACCGCCATCCTCCACCCTTCCTCCAGGCAAGGCAGC


CAGCTAAATCTCAATGACCACTTGCTTGGCCACTCTCCAAGTTCCACAGCCACAAGTGGGCCCGGTGGAGGCAGCCGGCACCGGCAG


GCCAGCCCCCTGGTGCACCGGCGGGACAGCAATCCCTTCACGGAGATAGCTATGAGCTCCTGCAAATACAGCGGTGGGGTCATGAAG


CCCCTCAGCCGCCTCAGCGCCTCTCGGAGAAACCTTATCGAGGCTGAGCCTGAGGGCCAACCCCTCCAGCTCTTCAGTCCCAGCAAC


CCCCCAGAGATTATCATCTCCTCCAGGGAGGATAACCATGCCCACCAGACTCTGCTCCATCACCCCAACGCTACCCACAACCACCAG


CATGCCGGCACCACGGCCGGCAGCACCACCTTCCCCAAAGCCAACAAGCGGAAAAACCAAAACATTGGCTATAAGCTGGGACACAGG


AGGGCCCTGTTTGAAAAGAGAAAGCGACTGAGTGACTATGCTCTGATTTTTGGGATGTTTGGAATTGTTGTTATGGTGATAGAGACC


GAACTGTCTTGGGGTTTGTACTCAAAGGATTCCATGTTTTCGTTGGCCCTGAAATGCCTTATCAGTTTATCCACCGTCATCCTGCTT


GGTTTGATCATCGCCTATCACACAAGGGAAGTACAGCTCTTTGTGATCGACAATGGTGCAGATGACTGGCGGATAGCCATGACCTAC


GAGCGTATCCTCTACATCAGCCTGGAGATGCTGGTGTGCGCCATCCACCCCATCCCTGGAGAGTACAAGTTCTTCTGGACTGCACGC


CTGGCCTTCTCCTATACCCCATCTCGGGCAGAGGCTGACGTGGACATTATTCTGTCCATCCCCATGTTCCTGCGCCTGTACCTGATC


GCCCGGGTCATGCTGCTCCATAGCAAACTCTTCACTGATGCCTCCTCCCGAACCATCGGGGCCCTCAACAAGATCAACTTCAACACC


CGATTCGTCATGAAGACGCTCATGACCATCTGCCCTGCCACGGTGCTGCTGGTGTTCAGCATCTCTCTGTGGATCATCGCTGCCTGG


ACTGTGCGAGTCTGTGAAAGGTACCATGATCAGCAGGATGTAACTAGTAACTTTCTGGGTGCCATGTGGCTCATCTCCATCACGTTC


CTTTCCATTGGCTATGGGGACATGGTGCCCCACACATACTGTGGGAAAGGTGTCTGTCTTCTCACCGGCATCATGGGTGCAGGCTGC


ACTGCCCTTGTGGTAGCTGTGGTTGCCCGAAAGCTCGAACTCACCAAAGCAGAGAAGCATGTGCACAACTTCATGATGGACACTCAG


CTCACCAAACGGATCAAGAATGCCGCCGCCAATGTCCTCCGGGAAACGTGGCTAATCTATAAACATACAAAGCTGCTAAAGAAGATT


GACCATGCCAAAATGCAGAACGTCATGTATGACTTAATCACGGAGCTCAATGACCGGAGTGAAGATCTAGAAAAGCAGATTGGCAGC


CTGGAGTCCAAGCTGGAGCACCTCACAGCCAGTTTCAATTCCCTGCCCCTGCTCATCGCAGATACCCTGCGCCAGCAGCAGCAGCAG


CTGCTCACTGCCTTCGTGGAGGCCCGGGGCATCAGTGTGGCCGTGGGAACTAGCCACGCCCCTCCCTCTGACAGCCCTATCGGGATC


AGCTCCACCTCTTTCCCAACCCCATACACAAGTTCAAGCAGTTGCTAAATAAAACTCCCCACTCCAGAAGCATTACCCATAGGTCTT


AAGATGCAAATCAACTCTCTCCTGGTCGCTTTGCTGTCAAGGAAGTTGCAGACCAGGGAACAGAACGAAGAGAGA





MOUSE PROTEIN SEQUENCE:mP27-009.1 (Seq ID No: 25)


MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQPPPPPAPPAVPQQPPGPLLQPQPPQPQQQQSQQQQQQQSQQQQQQAPLHPLP


QLAQLQSQLVNPGLLHSSPTAFRAPTSANSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEI


ANSSCKYSGGVMKPLSRLSASRRNLIEAEPEGQPLQLFSPSNPPEIIISSREDNHAHQTLLHHPNATHNHQHAGTTAGSTTFPKANK


RKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTVILLGLIIAYMTREVQLFVI


DNGADDWRIANTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLNSKLFTDASS


RSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYMDQQDVTSNFLGANWLISITFLSIGYGDMVPHTYCGK


GVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKMQNVMYDLITEL


NDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLTAFVEARGISVAVGTSHAPPSDSPIGISSTSFPTPYTSSSSC*





MOUSE PANTHER CLASSIFICATIONS


       FAMILY (SUBFAMILY)


              CF10153 (POTASSIUM INTERMEDIATE/SMALL CONDUCTANCE CALCIUM-ACTIVATED


CHANNEL)


       BIOLOGICAL PROCESS


              Transport (2.15.00.00.00) > Ion transport (2.15.01.00.00) > Cation


transport (2.15.01.01.00)


              Neuronal activities (2.18.00.00.00) > Synaptic


transmission (2.18.01.00.00)


       MOLECULAR FUNCTIONS


              Ion channel (1.03.00.00.00) > Voltage-gated ion channel (1.03.03.00.00) >


Voltage-gated potassium channel (1.03.03.03.00)





MOUSE GENE ONTOLOGY


              No Gene Ontology





MOUSE PROTEIN DOMAINS (INTERPRO SIGNATURES)


              IPR003931 (SKCHANNEL)


              IPR003931 (SKCHANNEL)


              IPR004178 (CaMBD)


              IPR003931 (SK channel)


              IPR000694 (PRO RICH)


              NULL (GLN RICH)


              IPR001622 (CHANNEL PORE K)


              IPR000694 (PRO RICH)


              NULL (GLN RICH)


              IPR001622 (CHANNEL PORE K)





HUMAN GENOMIC SEQUENCE:hD27-009 (Seq ID No: 26)


CTTACAATGTAACAGTGGCAGGAGGAGGCGAGCGAAGCTATTGAGCCAGCGAGGAGTGAAGCTGAGCCTGGCCTCACACGCTCCTAG


AGGACCACCTCCTGAGAGAGTTCTTTCACCCCCTCTTCTTTCTCCAAGCTCCCCTCCTGCTCTCCCTCCCTGCCCAATACAATGCAT


TCTTGAGTGGCAGCGTCTGGACTCCAGGCAGCCCCAGAGAACCGAAGCAAGCCAAAGAGAGGACTGGAGCCAAGATACTGGTGGGGG


AGATTGGATGCCTGGCTTTCTTTGAGGACATCTTTGGAGCGAGGGTGGCTTTGGGGTGGGGGCTTGTGCTGCAGGGAATACAGCCAG


GCCCCAAGATGGACACTTCTGGGCACTTCCATGACTCGGGGGTGGGGGACTTGGATGAAGACCCCAAGTGCCCCTGTCCATCCTCTG


GGGATGAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCCACCACCGCCAGCGCCACCAGCAGCCCCCCAGCAGCCCCTGG


GACCCTCGCTGCAGCCTCAGCCTCCGCAGCTTCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGC


CACCGCATCCCCTGTCTCAGCTCGCCCAACTCCAGAGCCAGCCCGTCCACCCTGGCCTGCTGCACTCCTCTCCCACCGCTTTCAGGG


CCCCCCCTTCGTCCAACTCCACCGCCATCCTCCACCCTTCCTCCAGGCAAGGCAGCCAGCTCAATCTCAATGACCACTTGCTTGGCC


ACTCTCCAAGTTCCACAGCTACAAGTGGGCCTGGCGGAGGCAGCCGGCACCGACAGGCCAGCCCCCTGGTGCACCGGCGGGACAGCA


ACCCCTTCACGGAGATCGCCATGAGCTCCTGCAAGTATAGCGGTGGGGTCATGAAGCCCCTCAGCCGCCTCAGCGCCTCCCGGAGGA


ACCTCATCGAGGCCGAGACTGAGGGCCAACCCCTCCAGCTTTTCAGCCCTAGCAACCCCCCGGAGATCGTCATCTCCTCCCGGGAGG


ACAACCATGCCCACCAGACCCTGCTCCATCACCCTAATGCCACCCACAACCACCAGCATGCCGGCACCACCGCCAGCAGCACCACCT


TCCCCAAAGCCAACAAGCGGAAAAACCAAAACATTGGCTATAAGCTGGGACACAGGAGGGCCCTGTTTGAAAAGAGAAAGCGACTGA


GTGACTATGCTCTGATTTTTGGGATGTTTGGAATTGTTGTTATGGTGATAGAGACCGAGCTCTCTTGGGGTTTGTACTCAAAGGTAG


GGGCTGTGGTTTCTCTTTATACCTTGAACAAAAGGAATATGTAGGTAGCAAGAGAGGGATTGAGAGAGGGGGATTGTGAGAGAGAGA


GATTGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGATTGAGAGATTGGGAGGGAGACTGGGAGAGAGAGGTGGTGGTGGTGGT


GAGAGGCGCTTGCTCAGTTATATTCAACACTCTAACTTCCCGTGGTTTTCCTTCTTGATCCCGGGAGAATTCATTCCTAGCTTCCTC


TGGGGGGTAGGGGACATCCCCACACACTGTGTCTAATTTGCAGACTCTCTGTTAGGGAGGATTCAATAATCCCTTCTGAGAAATCGC


TTTTCCTCCTGGCTCACTCGTACTAAAGCATAACCCAGCAGCTTAACGCACCAATTAATTACACTCCGCCTTCATGTGTTTGCCAGT


TCCTGCGACTTCCCCTTCTTTCCTCCCCTCCCTGCTCCACTCCATTTTCCTGAGGATAAAAAAGAAATAAATGTCTGGGTGGGGGGT


GGGGATTCCGTACCATTGCCCAAGTCCCTTCTCTCCCTGTCTTCTCCATCTCTTCCCAAGTTTCTGTTTCCCTCCTCTTCTCAGAGA


GTCTCGGGCAAAATAGAAAACCATCCATGACCTGGGTCTCCTGAGGGCATGGGGTAAAAATATAGGTGGAGGAAATCAGTGGTCCTT


TCCCTCAGGAGAGAGGACTCAGAATAAACCTGCTGCTGCTTCGTAAACATCTCCTGATAAAAATGGCTACAGGTGTTACCTGGGCAG


AGCAGCTGGGCGCCGCCTTGGAATCAGCTGGGGGAGCACCTCTCCTTGGGACGGGATGACAGGGCTTCCCAGGCGGTCCCCACAAGC


CCGCGCCCCAGCTCAGCCCCAGTTCTCCCCTCCCACCTCAACTCCTCCTTGGGATAAATAAAGATGAGTGTGTGTGTGAGTGCGCGC


CCGGATGGAGAACAGCAGGCACTGGCTTTAGCGGGGAGCTGGCCCCACTGCTCCAGCCTCTCAGTCCAGCCCCAAGACGGAGGAGGG


GGTTTCCCTCCCAGAGGGAGTGGAGATGGAGGAAGGTGGGTTTCTGCCGATGCTCTGCTTGCCGGGGAGCTCTCCTGCTGTGGGCTG


GAAGGCTTGGAGACCTGGGAATCGGTGGACAAGTGGCTCCACGATACCCCCACCCCCAATTTGTTGGTGTGTGTGTGTGTATGTGCG


TAATGTTTGTACGTATGCATGCGCCTGCTTGTTGCTTGGGTTTTTCTATTTATTTGTCATTTGGGGCAGGGGGTGGCTTGGTGGGGG


GGTGGCTGGGCGGGCTGGCCATCGGGTAGCTGGGAGGGGTTCAGCTGTTGGAGGTTTCAAATAGAGCTTGTTTCAGGCAGGGCACAG


CTGCTGCGAGACTGTCACATTCCTTATTGAAATCCAGCCGCAAAAACCTAGGAGGTGCTGATCGGATTTCCCCCATTCCCAGCATCT


CACTTTAATCGGTGATGGGCAGACTTTCCCGCCCTGGAAACGGGTGGGGCAGACCTGTCAGACGACCTGAATAGCCAGGACCAAGAC


TTCCAGGCAGAGGGTCCTCCAGCAACCCGGCTGCTCTCTCAGTGGGCTGCCCCAGCGGAGGGCAGCACCTGGAAGCCGCCTTAGTCA


AAATAGCTCAAGGATGAGCGTCTCAGCGAGCAGAAGCGAGTGGGGTTTCCCTTGGAAGCGCAGCTCACTTAGTCATTCCCTGTAATG


AGCCTCTGCGTCTGCGGGTCCTTCTGCTCGCTGCCTTCTCAGAACCGCCTCTCCTGCTGGGCGCTCCAGGATATGGGGCTGGCAGCC


TCGCTAGGACTGGCAGCTGCCCTGGTCACAGCCCTGGCTCTCTCCAGTCCTCCCTTGGAGACCAGGGGCCCTCACTGGGGAAAACTG


ATGAAGGCCCAAATGCAAGGGGGGTGTGGGGAAGGGGCAATCCCAGCACCTTCTCTTTCAGTGACACCCGTAGTCAGAGTTCTTAAG


GAAACGGCTATTCCCAGAGACAGTGGCTGTGCACAGATCCCAGTGTGGGATCTATGCACATTTGTCTTAACGCGACGGGAGAGTCAC


CACTCTGCAGGATCAGGCCCTCTTCCCTGCCTGGGGCAGGTGCCACCCCTGAGGGGGAGCTCAGGGAAAGGGGCTTTCCCAGAGATG


CGGAAGGCAGATTTTAGGTGAATGAAAGGGGAGGCCACCTGAGGTGCTTGGCTCCCCGCATTTCTGAATCACAGACCCTCATAGCAG


CAGTGGCGTGCACCGAGGGGGCAGTAGCTGAGAGGTCCTTCTTGCCTCAGCGGCCACTTCCTGTGTGCCTTGGGGCTGGTCTTGAGA


TAAGCAGAGCTCATTTAACTTGCTCACTCATTCACCCATCCCTGCACTGTCCATCCATGTTTTGAGTCATTTATGAAACAAGTATTT


TCTGGGTGTCTCCTATGTACCAGGCCTTGTACACACTGCAGGGCCAAGATAGATATCCCTCTCTCCTGGAGGCAAATGGGAACATTT


CAAGGAACTGGGCCAGAGTTGGAATCCCAGCTCTGCCACTACTATTTGTGTGATCTTGGATAAGTCATGGAGCTTTAGCGAGCCTGT


TTCCCCAGCTGTCGAGTAGGGAGAATTAAATTAGAGACGTGTAAGGCACGTATCTGCCTGCTCAACAAATGGGACCTATTGTGATTG


TTACTGATGATGACAATGATGAGAGGAAAGGAGATATCTTTTTCCTGTTATCTAACTCTGGCTGTAAAATTAGTTGGAGCTTTAACA


GATTGGGATCTAAGACTTGTCAACGGAGTGAGAAGTTGTATCTGGGAGGGAAGAAGTCCTGAGAAGGGACTGGGTCTGACTAGAGAC


CACCTTTAAGCATGGTTTATTCTTGGGGGGAGGTGAATATCTGTGTCCCAGTTTCATGGAGGAAGTGGTCTCTACTCCTCCATGGTC


TGGGTTAGTCACAGCCCAGGAGAGCTCAGGGACATTCAGTGGACCCTGGGGAGGGATGGGTGACACTCTTTTGCTGGAGAGCTTTGT


GTGCCTGGTTGGCCCTGCTGACCAGTCTGGAGGCAGGCGGATGGACAAGGCAACCTCAGGGGTACCAGGCAGATTAGGTAATTCTGC


CCATCCAGTGGCAGCTCCCACTCAAAGGCCCTTGGGAGGTGACAAACTTTTTTTTTCCCCAGGTGATTGAAGATTAACTAACCTTGT


GCCTGAGCTGCTGCTTTCTGAAGTTCTCTGCTTTTTTTTCCGTGGGGTTGTGGCCTTGCTGTTCACCTATGTTTGGCGGGTGGCTGC


TGCTGGGGAAGTAACTTGTCATGCAGGCCTGGGTCTTTTGAAAAGGAGGGTGGCATGTGCCCTGAGCATGTTCAGTTAATGCAAATG


GGAGCCAATGTGAGGGGGTTGAGCAACCGGGACAGAACATCCCCAGCTCCTGCCTCACAGGCCTGTAGGTGCTGATGATGGAAGTAA


GCTCTGCTAGGAGGCATCAGCCTGGAGCAGGGAGGTGGGGCTTGATTCCTGGGTGAGCTCAGATAAGAGGAGAGCTTCTCATTATTA


TGCCTGGGACATGAGATCAAACGGCAGAGATGCCTGAGATGGCCCCAGTGGGCTCCTAAAGGTACCAGGTGACCCTTGAACCAAATG


AGGAGTCCTTTTTTTTTTTTTAATAGGCAGGTTTACTCTCTGAAGTCTTAGACATTGTGACGAGGCCTGGTCTAGAGATTCTGTTGA


GAATCTTAATCACATCATCTGTACTGATCGGTGCCACCTGGGTAGACCAGCAAGGACCTGGGGAGTCCTTCTTAGTGTTCTTTATTT


TCTTTTAGAGCTGGTTTGGGGCACACCCACTCCATTGCATTAAATTACCTGTATGCTCTCTTCCCTGGGTTCAGAAAGAATTAGGGA


AGGGAAAGGCCTGGCTGCCCTCCCCTTTCCCCAGGCTGTGACTTCACCACCCTGACCCTGCCATCATGTTGGTGGCTGAGCTGGTAC


CTCTGTGTGGCTGGCAAGGCACCCAGGGGCCTTGTTTCTCGGGATCTCAGGCGTTGGGCTGTGGGATCTTCTCAGGGGAGGCTGGAG


AGTGCTGGTGTGGCAGCATGGCTCTTCTTTTCCACCAATCTGTACAACCTCAAGCCACTTCCCCATGCCCGGCCTTGAAACTGGTCT


GCATCTCTCCTCCCAGGCAGAACCAGTCCTCTGCCCACTCCCCCACCATGCTCCTGTCTCGCCTGCCCCACTGATTTCCTGCCCCTC


TGCTCCTCTCTGTGGCCCCTGCCTGGCCTCGTTGCTGGGGTAACCCAGGTGGCAGAGAGGAGTTGGTGTGAAGATGCTTATCCAGGC


TGCCCTGTCTGCTCCCACAGTGTCTTCTTTTCCCACTTCTAGTTACTCTTTCTTCAGACAACCTCATGGGAGGCCGCTTCTCCGTAT


GCCCAGGGGAGCCTGGTCGTCTGGCCATTCACTCTTTAAACAGAATGGCCAAGGCCAACTTGTCTGTCTCTTTGCAGACCTCACAGA


GGTCCCTGAGTCCATCCCCAGCCTCTAGACCAAATGATTGAGTAGTATCACTGGAACCAGTTCTGATCCTCTGCTCTCCCTGGTCAC


GGAAGCCTTGTCTGCAGAAGGGCAGAGCAGCAGTGCAGGCTTGGCTAGCCAAGTGGCTCTGCACCTTCTGTTTGGACCCAGGTGCTG


CTTTGGGATAGGTTGTTGGCTGTCACAGTGTCCTGGTATTTTTGAGAAGATGCCTCTGGGTACTGGTGCCTGTGTTTCAGGCCATGG


TGGAAAAGTAGGAGTAGGATAGACCCTTTCCAGCCCTTTCCATGGACCCTCCCTGTGGGGTGACCTGCAGGACCAGGATGCAGAAGG


CAGGAGACTGGCTGAGAGCCTGCGAGCCCACTGCCGAGGGCCCTAGGCACACATTTTGTCTTCACAGGTCACACTGAGTGTGTCGGC


CCACAGGAGGGCAAGCGTGAAAATGGCCTTTTGACAGCGTGAAAATGGCCTTCTCCGCCACCCGCCCCAGGGTGGTGGTGACTTTAT


TTATAATCTTTGTGGACAGTCTGTAAATGAGTCAAACATCTCTAACCCACAGGGGGACAGCTAACTTTTTATATATGCTTCTCCTTT


GCGTGTCATCACACTATTTATAACTGTCCTGGGGAAAGACTTCATCACACATCCGGACTTCCCTTCCCCACAGGCGGCATTACCCAG


GTGCTCCGCCAGGGGCATCCTGGCTGGGGCACTTATCTCCTGCACAGCCTAAGTAGAAAGGCGGCTGATGCCTCGTATTTCTCTTAT


TGTGCTTTTAGGAAGAGGGATTTGTAAGGCCATGGTCAAAAGATCTGCTTTAAAAAAATATAAGGTAAAGAAAGTCAAAATGAAAAG


AAATTTGAGTAACCTCTGTAGAGAATCTGGGGCCTGGATGGAAATGTAAGATCAGAATAGAGCGCTTCAGCTCTGTTGCAGTTATTT


GTGAAGCACATTTGGGGGAGAAAATGAGTGTGTGCGGGGGTTGTGACGGGCGGCTGTATATTCATGAAATACCACTTTACTCAGCTC


AGTGACAGGCAGGCCAGCACATTCATTTGTAGTTCTTTTTCTTCTCTTTCTTTCAAAACCCCAAAAGGAGAGCAAGAAAGCAAGGCA


CCTATTCCTCTTTAAATAATGAGGGTGGGGAATTCTGAGACTGTGCTTTTCCCAGGAGCTGTAGGGAGGAAAATTCTAGTGCCTTTT


CTTCGGGTGAGGAAAGTCCGGAGGAGGCGAATGGGTTTTTAAGTGCCCCCTCCCCCGACCCTGTCATTCCACCCCCAGGAGCTCAGC


TGGGATCTGAGGGAAAGGAGGGGAGGAGCAGCTGGGGGCAGGGACCACGCTACTTTCTGGTCACCCAGCACTTCGCTGGGCTGGCCG


GGATGTTGCTGAGTGACAGGAGAGGGGAAGGCAAGGACCATTTGCTGAGTGCTGGGCTGGCTTTACATTACACCCGGGAGTACAAGG


AGCAGGTCGTGCTCACCGCCCCCTGTGTAGATGAAGTCACCGGGCCACACTGACACTGCCAGCGGTGGTGGCACTGAGATAAGAACC


CAAGCCCGTTTAGCTCCCAAGTTCATGCCCTTTCCCTTGCCTGCTGCTGCCCATATCCTTAAAAGAGAAAAATTGAGTTTATGGCAC


TGAGACCCGTGATGCAAAATGTTGGAACAGGAGGAACTTTACCACGAGCTGGGCAGGAAGGGCTTGATGGAGGGCGGGAGATGCTGG


CGCAGGTCCTGGAGAAGACAGTGCTGGAGGGGTGGCCACGGCAAGTGTGGGCACCCCACGTTGGCCTGGGATCAGGGTGAGATTGTG


GACTGGCCCAAGGTCAGTTCTTGATGCCTCCTCTCTGGGGTCTGGTGCTGCTGCCCTCAGGGTGATACCGGGCAGGTTGTGAGGAGG


GTAGGTGTGGAGAATACAGGGAAAATGAAAGCCCTTCCTGCAAAAGCTCCTTCCACAGCCCCTAGCACCCCCACCTTCCACCCCTGG


AGGGCCAGCAGGACCCCTAGACCTGACTGGACATGTCCATACATAACTCTCTCACCCCTCACCTCCACCTTGCTCTTCTCTTAGGCT


GCCTTTCTCCTCCAGCACTGGCTGTGTGGCTGTTTATCGGGGGACAGTCACATGAGCTCAGCATCTTACATCTTACAAGGCATTTTC


ACCCCTGGGTCCCTCATGACCCTCACGGTGGCTGGCCCAGGGCTCATGATGACCAACTATCTCAGGGATGAGAAAACTCGGCTGCAC


AGGGGTTCCCAGGGTTGAGTGACTCACTCCAGGTGCCCATCTCAGGAAAGAGAGGGTTCTAGAATGAGAGCTCAGGTCTCAGTACAC


TTCTGATTTCCCTATTCCAAACCCCACCACAAACTTCTGCTGCGGATTTGAGTGAGGGACCTCGAAGGGCTTCTCCATTCCTGGTTC


TAGAAGTTTCTTTTTCATTCTTGAGTCCCATTTTCCTGCGTCCCTGTCTGTGCCTCATGCCTCTGTTGAGCTCTGTCATGGGCAGTG


AGTGCCGAGAAAAGGCCCGTCTCTGCTTTGAGCCCCTCAGGAGGTGCTTCTGCCTCTTGCTTCCAGCTTGTTGTGTGATCTTTGTCG


AGTCCCTTCCCCTCTCTGGGCCTCGTTTCTCTGGCCTAAAAACAGGAGCTGAACTCCCTTCCTGTGCCGAGGCTTCGCAATCTGATT


CCAGATCATGTTTCATCACGAGGATGAGCAGCCACAGTCCGGAGAGTCCTGTTCTTAGGGGTGTCAGACAGCACCCAGATGGCATCC


ATCCCAGGCGGATGGTGGTTTATGGTGTTGGTGCTTGGGAGGACTGAGGAAGGAGACAGTGACTCAGACTGGGGATGCTGGGTGGAT


TCCCTGTAGGAGGTTGGGGGGTCCCTGAAGGACTAGACAAGCCATGATGGGAGGGGCTCGGGCAGGGGCTCAATTCTGAGTGTGAGA


AGCCCGGGGAGAGGGGGCAGAGTGTGTAGGGAATAGAGCAGGCCTGAGGGCAGCTTCAGGTTGCTGCCGTGTGGTGCACACAGGGGC


ATGTAGGGAGGAAAGAGGAGACTGTCTCGTCTGGAGAGGCTTTGGGCAGGCAGTGAACACAGGCCCAGGGCGAGGGCACAGTGATGG


ATGGAATATTTGGTAGCATCAGTAACCACCAGGGCTGCAGAGTTCTGCACACTCAGGCCCCGAAGACCTGATATCCTTCCTTTTAGA


GGTGGCCAGGCTTGGTAGTTAAGGACTTGGGGCCAGGCGCGGTGGCTCATACCTGTAATCGCAGCACTTTGAGAGGCCAAGGAGGGT


GGATCACCTGAGGTCAGGAGCTCGAGACCAGCCTGGCCAACATGGCGAAACCTCATCTCTACTAAAAATAAGAAAATTAGCCGGACC


TGGTGGCTCACGCCTGTTATCCCAGCTCCTTGGGAGGCTGAGGCTGGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCC


GAGATCCCGCCACTGCACTCCAGCCTGGGCAACAGAGTGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAACTTGGGTGGCACACC


AGTGATGGGCGCTCTGGGAACTTACTGAACCCAAAGCCTATTTCCTCAGTGTTAAGAGGGAATCACAACTACTGGCTGTAGCACAGC


AGCCACCACAGAGCCAGCCACACACTGGGTCTCAGCAGCTGGCAACTGTTGCCTTTATTAGAGTGGTGGTTAGAAGATGCCACCTGG


AGCATCAAGACAGGAGGGGCATATGCGCCCATGTCACCCCTCCACTGTCTGCAGGTGTCCCTGCCTGGAGAGCACGTGTGGAACATG


CCCCTTTTCTCATGAGCCAAATGGCTTCCCGTCCGTGACAAGCTCCCCAGTCATGTTTCTGGATAGACCTTGTTGGGTGAATCTGTG


TGAGTAAAAAGGAAGTGGGCTCTTCTCCGGAGGGCAGGGCTGCAGTGGTGGCCTGGGCTGGACTTCTGGAGCCTTCTTACCCCATGG


GGCCCTGTTATTCTACACTCAGTTAGCAATTTGTGGTCTGGGCAGAGCTAACCGGGTGTGGACATGCAAATCGGACAGGTGGAGAGA


GAACAAAAATAAACCCGTGGGGCCAGGCCAGAGGCTGAGAGGCCTGGAGGAAGGTCAGGGGGACACACGATGACCAGGCAGAAAAAG


GCTGAGAGAGTAGGGCCACAGGGAGAGCCGAACTAGGAAGCTGACCTGGGACAGAAGCAGGGAAGAAAAGCATTGCCACAGCTTGCC


TGATGCGTCGTCAAGAGAACACAATTTCCCCTTCAAGACTTGAGTCAGGGTGCTTTCTAGAATTCTAAAGATTCTTTCTGCCCCTTC


ACCCTGCTTGGAGCACCAGGGCTGTGGCAGTGGGTGACGTTCCCAGCCAGGTGCCAGGGGGCAGGCAGCAAGAGCAGCTGGGCAGGG


GAGGGACGTGCCCAGGGCTTGCCCTTTGTGGAAGCCATATCTGTTTCACAAGCCCTGGGCACAGGGTAACCAGAGTTGTATTCTGAG


CAGAGCCTTGATGATACTAAATGAACAGCATGCAAATGATGTGTGAAATAATATGCAAATTGGCATCTGTTATTTTTGAGTCAGCTT


GTTGGGCATTTTTCTTAAAGGACAGGAGTGCTGCTCAGTGTCAAATGAACAGGAAAGTCAGCTTAAAGGACACTCCTTACAGGGACT


GAGCTGGCACCTACTCCTTAGAGCTTGCTGATACCAGGCCTGCCACGCGACATCTGCAAGGACAGTTGTTTGGTGTTTTGCTTCAGG


TTATAGATGGAGAGACCTATAAAGGTGGGTGCCCTGCCCAGGTTACCCAGTAGGTAGGGAGGAGGAAGCAGATGACCTGTTGCCTGG


CTTGAGCCATTGAACCTTGCTGACCTGTCAGTGGCTTTGAGCTGAGGGGGCCCTGCAGGGAGGCAGGGAGAGGCTGCCCTTGCTCAT


TCTGGTCCATCTGCCACCGTTGGTTTTCCTTAAGCTCTCTGCCTCAAACTCTCCGAGCCTCAGTGTCCCCGTTTGTAATGGATGTGG


GGAGACTGACATCCACTAACCTGGGGAGGATGACACTTGCTAGTGGTTGGTCAAGTGGCCAGCCTGGCTGTGGGTGCTCCTGGGCTG


CCAGCAAGTGGTGGCTCCTCCTAGCCCCTTTGCCTGAGTTGGCATCAGCCTGCCTCCTCGCAAGCTTCCACTAGCAGCGATTTTTGC


AGAGCAAAACCCCTTTTGAGATTTCTGATTTTAACGAATTGGAGTTTAGCTATTTTCTTTCTTTTCTGGCTTCCAGTGGGTAAGATG


TTGGCTCCCCAAAAATCTCCCATACATGGGAATGGCCGGAGCTGCCTGCATGGGTGATGTTACCTTCTCCCAAGGTGAGGGCTTGGG


GTAGGCATGTTGCTCAGGGTTGAGCCACCGCCTTTGGAGGGCTCAGAGCTGGATGGCATTGGTGGAGGATGCAGGGGAGGCCTCCTC


AGGGGCGCACCATACCTGCCCTAGATGGCCAAGCTCTGTAGGCCAGCCAGGTGTGCTAGCCTGGGTGGGCAAGATCCCTGCATATGC


CTCCCAGCCCTGTGAGGAAGGCAGGGAAAGGACCATCCTCCTCCTTATAGGACCCCAAGGCCCATAGAAGTTATGCGGTGGCTCACA


CCTGTAATCCAGCACTTTGGGAGGCTGAGGCGGGAGGATCGGTTGAGTCCAGGACCTCAAGACCAGCCTGGGCAACATAGTGACACC


TTGTCTCAAAAAAAAAAAAAAAAAAGTTACATGACTTGTCCGAGGCTACTCAGCATTGTTAGTGGCAGGGGCATAGCTGGAATCCTG


GAATTCCTGGTTTTAGTTCTTCCTCTCTTTTTGTTTCTCCCATCCCTCTTCTGGAAACATATCCTGAACACCCACTGTGTGGCAAGC


CCTGCTCCAGGCGGCAGCAGTGCAGAGAATCTGTGCCTTACAGACTCCAGGGGGGTCTCTCCCCAGCCAGATGTGTTGTTCTCCACC


AACTCTTCCTAAGAGAGCACAGGCTTTCCCCATAGACCTGGATTCAAATCCTGGCTATTTGGCTGTGTGGCCTTGCGCAGCGGCCCC


TTTATTTGGGAGGTGGTATTTTAATTCCTCTTGTGGGTGGAGAGGTGAAGAATTCAACGTGGGCCAGAGCTGTCACCCAGGGGGCTC


TTGTCCATGCTGGGCAATGCTGGGTTTTACCTTGGTTGTTTCTTCTGAGAGCTCAGTGGCCTTGGGATCATGCAAGGTCCCTCACAG


CTGGGCCCATGGTTCCCAGCCCCTCCTGCTCTGGGCTGGACCTGGTGTTAAGCTCTGCCAAGATGCTTTCCCCTGCTCTGGGAGAGT


AATGGTGCTGAGCCTGGTGGGAGGGCATTTTGGCAGAAGACACCTGACGGGGTGCACACTATGTGCCAGCGATGGAAAGATCCCTTA


AGAGTGAAATGAAATTGATGCAAGCTGAGAGCAAGTCTAGGATGGAGTTGAGTCATGAGGGTTTCCTGGTGGGTGGACGGGATCATA


TAGAAAGAAAGCCTGTGTCCACAGCAGCTTGGGGGAAGGCACCGCTCTCATTACATGGGAACTTATTTTTCCTTCCGTAAGAATGAC


TCCAAAGCAACACCGGGTCTTATTCAGGAGTGAAGAGGTGACAGGCGGTGGAGAAGAGAATATTTATTAAGGGCCTACTATGTGTGT


TTACACACCTCATCTCATTAAGTCCTCACAACAACCCTGTGAGGTAGATATAATTCTCCCCATTTTACAGATGACAGACCCAAGGCT


CCGAGAGTTTAAGTGACTTGCTCAGGGTCTCACAGCTGGGAGGTGGTGGAGTTTGGATTTGCACACAGGGGAGTGTCTCCGACGCCC


TCACATTGTGCAGCAGACATGCTTTTGCATATCAGATCCTAGACTGGGCTCTTTCAAGCCAAAAAGCTTCTCCTGCCCTGCCTGAGC


TCTCCACTCCCGCCCACCCCACCCCTTACTGTGCCACCCTCAGTCCCCTGCCAGCCTCCCCCAGAGCCTCAGGGGATGTTTTGTGCT


CATGGAGTGGGGTAAGGGTACAGGGAGGAGGGGAGGAGGATGCTGGCAGTTTAGATACAGGGGTTTGCTGAAGCTCCAGGTGCCGTG


CTGGGCTCTGGGGCTGAGGAAAGTCTCCTGTGGGCCCTGGAGGGGCCACCCGAGCCCTCAACAGCATGCGTCCTAGTGTTCTTGCCG


CAGCTCTGTGGCTTCTCGGCTGTGCAGCCTTGTTGAGAAAACTGACCTCTTTGAGCCTCAGTCTCCAGGTCTGTGAATGGGGTTAAC


AGTGTTTTCTCTCTCTCATGAGAATGGGTGTCATGAGGAATAAATGAGACAAGGGCACTGCCTGGCGTGTTCTGGTTGGTTCTGGGG


GTTCAGCACCAAATAGACATGGAGCTCACAGGCTGGTGGGGGAGGCAGGCACTGAACAAGTAACAACAGGTCTGATGTGAGCTTTGC


GAGAGACAAGGGCACACACATGTGGCTTGGGTTTGACCCACAAGCCTGAGACTTGGTGTCCCACGCCTCCGTCTGCTCCCCTTCCCC


CCATTTCCTGAAGGTCCATCTCACCCTCACTTCTTCCATCCTCCCTCATATCTGTCTCCCAGGCCATCCTCTGATTCTTCTATATGG


GCTATCTAGCCTGGTGTTAGGAGAACAGGCTTTACTGCCAAGCAGATATTGGGTACAGCGCTGGCTGTGTCACTTACTGTAGGCTGT


GTGGCTTTGGGAAGCTGTCTCAGTGCTTTGATTCACAGTTTCCATGGGGGTGAATCCTAACCTGGCCGCTGGGGCTGTCATGAGAGT


TAATGAGATATTGCTGTTTGTAAGGCAGAGGACATGGTTTCTGGCACACATGGAGCGCTCTGTGAAGGCCAGCTGAGTTGCAGGTGA


GGAGAAGCATCCTAGGCTAGGTGTGGGGCAGCTTAGTTTCTGGTCCTCTGTTTTGTCATCTAGAGAGTGAGAGAAGGAGCCTGAGGA


GGGGATGTTTCCTGCACTGGCCATCTGCGGGAAGGTCGTGAGCACCAGATGGAATTTCGGAGAGAACTGGAAGAAAGCTACGCTATT


CCAGCTGGCGGGGGTCCTCATCGATGGTGCATGTTGGCAGGGTGGGCTGCGGGGGGCGTTATCTTCCTATCCCACAAGCGAAAGCCT


GTGAAGACATCGTGGCTAAGGGGATTTTCTCACTCTCAGGAGACAGCTGAGAGACAGGCCCTTCTGGCCAGCCTCCCTCCCTGCTGC


CTCCTCCCTGCAGGCCAGCCCTTCGCACGAGTCCTGCTTGTCTCCTGAACCCTCCTAGCAGCAGGGATTTAATTACTATAATGTAAG


TAGCTGTGGCTTGAGGCCTTCTGGTGGAGGGGAAACAGATTTGTCTTCTCACTGGGAGAATAAAAGTCTATGGAAAGGAAAAGAAAT


GTACTTTTCCCCGAGGTACCTGAGGCTGTTGGGCTCAGGGGAGCTTCCCTCAGGGCGGGGAGAGGGAGCATGGGTGGCAGCGGGAGG


AGGCACCACGTCTGACTCAAGGACCCTTGGCGCTTGCTTTTGCTCTCTGTGGGATCACTCAGCTAAGCTGCCTCAGTTTCCCCAATG


ACCCTGCTAACAGATCAGCCTGACATTCAGTAGGCATCTGTCAAGCACCTACCATATGCTAGACACTTAGAAACTTCCAGCTGAGTA


GCCAGCCCAGGCGGAAAAATAATTTCATTCATTTGACAAAGTTATTGAATGCCTGTTATGTGCCAGTGTATTGTTCTAGGCATCACA


GATATACAGTCATGCGTTGCAACGACGGGGACGCAGTCTAAGAAATGTGTCATTAGGCAATTTCATCATTGTGTGAGCATCATGCAG


TGCACTTACACAGACTAGGTGGCATGGCCTTCTGCACACGAGGCTGTATGGTGTAGCCTACTGCTCCCAGGCCTGTATTGAATACTG


TAGGCAATCATAACACAATGGCAAGTATGTATCTAAACATAGAAAAGGTACAGTAGAAATACTGTACAATGGATACAAAATACTACA


CCTGTATAGGGCACTTACCATGAATGGAGCTTGCAGGACTGGAGGTTGCTGTGGGTGAGTCAGTGAGTGAGTGGAGAGTGAATGTGA


GGGCCTAGGACATGACTGTAGACTAGTGTAGGCTTTGTAAACACTGTTCACTTAGGCTAACTACATTTATTTAAAATATTTTTTTCT


TCAATAACAAGTTAACCTTACCTTACTATAATTTTATTTATTTATTTATTTATTTATTTATTTTGAGACAGAGTCTCACTCTGTAGC


CCAGGCTGGAGTGCAGTGGCACGATCTCGGCTCACTGCAACTTCAACCTCCCAGGTTCAAAGAATTCTCCTGCCTCAGCCTCCTGAG


TACCTGGGATTATAGGCACGTGCCATCACACCCGGCTAATTTTTGTATTTTTAGTAGAGACAAAGTTTCTCCATGTAGGCTAGGCTA


GTCTCAAACTCCTGACCTCAAGTGATCCACCCGCCTTGGCCTCTCAAAGTGCTGGGATGACAGGCATGAGCCACTGCGCTTGGCCAA


ATTTTTCACTTTATAAGCTTTTTATACTCTTTTGTAATAACACAAACACATTATACAATTGCACGAAAGTATTTTCTTTATATTCTT


ACTCTATAAGTTTTTTTCCATTTTAGAAATATTTATTTAAAAAGATGCATTTTTACTTACAAAATCTTTTTTGGTTAAAAACTGAGA


CACAAACACACGTTAGCCTGGGCTGACACAGGTTCAGGATCATCAAGATGTCACGAAGTGATAGGAATTTTTCAGCTCCATTATAAT


TGTACAGGACCTTGACTGAAATGTCATTATGGGACACATGACTGTAGTAGAAAAAACCCACAAAAGAGAAAAATCTTTGCTGTCACG


AATTTACATTTTAATAGATAAGCCTGATAGTAAACTATCTAAGTTAATTATATATTATGTTCGATGGTGATAAGTGCTATGATGAGT


GTTATGAAGAGCCTCTTCCCTCCAAGATACAACTTCTTACTCCATTGACAAGTCTTAGATCCCAATCTGTTAAGGCCCCAACTAATT


TTACAGCCAGAGTTAGATAACAGGAAAAAGACATCTCTTTTCCTTTCATCATTGTCATCATCAATAACAATCACAATTGTTAGGACC


ACTCTGGATGGGAGTGCAGGGGCTTCTGAGAGGAGAGTGGTCATATTATTTTATTTATTTTCAAATTAATTTATTATTATTATTATT


TTTGAGATGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTTCAGTGGCCCAATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACG


CTATCCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACCACAGGTGCCTGCCACAACACCTGGCTAATTTTTTGTATTTTTAGTAGAGA


CGGGGTTTCACCATATTAGCCAGGATGGTCTTGATCTCCTGACCTCATGATCTGCCTGCCTTGGCCTCCCGAGATGCTGGGATTATA


GGCATAAGCCACCGCGCCCAGCTTTTTTTTTGTGAGACGGAGTCTCACTCTGTCACCCAGACTGGAGTGCAGTGGCGTGATCTCGGC


TCACTGCAACTTCCGCCTCCCAGATTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTGCAGGCACATACCACCATGC


CCAGTTAATTTTTGTATTTTTAGTAGATACTGGGTTTCATCATGTTGGTCAGGCTGGTCTTGAACCCCTGACCTCAAGTGATCTGCC


TGCCTTGCCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCATGCCCGGCTGAGAGTGGTCATTTTAAATAAATGCTCAGAGCT


AGGTGCAGTGGCTAATGCCTGTAATTCTAGCACTTTGAGAGGCCGAGGCAGGAGGATCGCTTGAGCTCAGGAGTTTGAGACCAGCCT


AGGCCATATAGTGAGACGCCTTCTAAACAAAACAAAAAATTAGCTGGGCATGGTGGTGCGTGCCTGTGGTCCCAGCTACTTGGGAGT


CTGAGGTGGGAGGATCGCTTGAGCCCAGGAGGTCAAAGCTGTAGTGAGCTGTGATCGTGCCACTGCACTCCAGCCTGGGGAATAGAG


TGAGACCTGGTCTCAAACAAAAACAAAAACAAAAACAAAAAACAAAAACCACAAATAAAACAAATAAAGAAGTGCTTAGGGCCAGGC


ATGGTAGCTCACGCCTATTATCCTGGCACTTTGGGAGGCCAAGGCAAGAGGCTTGCTTGAAGCCAGGAGTTTGAGACCAGCCAGGAC


AGCATGGCAAGACTCTCATCTTTACAGAAAAAAAAAAAAAGCTGAGTACATTGGTGTGCACCTGTAGTCCTAGCTACTTGGGTGGCT


GGGGTGGGAAGATCCCGTAAGCCCAGGAATTCGAGGATGCAGTGAGCTGTGATTACGCCACTGTGCTCCAGCCTGGGTGACATGTGA


AACCCTGTCTCTAAAAATAAACACATAAATAAATAAATTAAATAAGTGCTCAGGGAAGGCCTTACCAAAAAGGTGATGTCTATTGGA


GGATCTGAAGTGGTGAGGGATCCAGCCACCTGGGGGAAGAGGAATAGCAAGGTGAAGGCCCTGAGGGGGGATCATGCCTGGTGTGTT


GTAGACAGCACTGTCCGGTGGACACGAAATGGGAGCTACCGCTGTCATTTTAAATTCCTGAGTAGCCATATTAAAAATAGTGAAAAG


AGAAAAGTAGAATTATACATGTTAATAATATTTTTAATTTAACCCAACATAGCCAGAATATTATTATTTGAATGTGCAAGCAATACA


AAAAATTATTGAGATCTTTTACACTTTATTTTTTGTACTAAGTCTTTGAAATCTGGTGTGTCTCTGACACAGCATATCTCAATCAGA


CATTAAGTTTTCATTGGAGATACTTGATCTGTATTTAGAGTTTATAAAATTTACAATTAAAAGAACAGACTTGCTGGCCATGGTGGC


TGACACCTGTAATCCCAGCACTTTGGGAGGCAGAGGCAGGTGGATTGCTTAAGGCCAGGAGTTCGAGTCCAGCCTGGGTAATGTAAC


ACAGTGAGACTCTATCTCTCTAAAAAAAAAAAAAAAAAAAATTAGCTGGGTGTGTGGCATATGCCTGTGGTTCTAGCTACTTGGGAG


GTTGAGGTGGGGGATAGCTTGCTGTTGAGGCTGTGGTGAGCCATGCGTGTGCCTCTGCACTCCAGCCTGGGCAGCAGAGCAAGACCC


TGACTCCCCGTCCGAGAAAAAAAAAAGAATAGATTCACACACTCAAGTTGTTGAAAACGTACTTAAAATTTTTCCAATAAAAGAGTG


GAGTGTCTTTTTATATTTAATTTTAAATGAAATGGACTTAAAATCCAGTTGCACTGGTCATGTTGCAGGGGCTCAGTGGACACACGT


GGCTCGTGTCCTCACACTGGACGGTGCAGGCCTGGGAGCAGAGAGGATGCCTGTGAGGCTGATTCAGTGAGTGGAGGGATCATGTGG


GCGGGGTTGTGAGGTCACAGGGGAGGCGGGTCTGGCTCTGCAGGGATTTGTAGACCGTCCTGAGGAGTGTGGCCTTTACCCTGGGTG


AGATGGGAGCAAGAGGAGGGCTTGGAGTAGAGAAGTGACAAGATCTGACTTACATTTTAATGGGACCACTCTGACTGCAGTGTTTGG


AACAGACAGGGAGGGTCAAGCCAGGGTCAGGGAGCCCCGCTGAGAGGCTGTGGGGACAGCTCAGGTGAGGGTGGTGATGGTTTGGAC


CTGGGTGGTAGCATTGAGTTGGTAAAAAGTGGCTGGACCCTTGGGCTATTTAAAAGGAGGGCATTCCTGATGAATTGGACAAAAGGT


CATGGTGTGCAGGTCAGGCAGTGGTGAGAGAAAGGGGAAGTCAAGGATGAGGCTGAGACTTTTGGCCCAAGCAACTGGAAGGATGGA


ATTTCTGTTAATTGAATGGAGAAGACTGTGGGAGAAGCAGTTTTTTTGGGGAAGACAGGGAGTTTGTGGTTGGACTCGTTAAGTTTG


AGGTGTATCAATTTCCATATAATGCGTGTAGCACCTGCCCCAGGGGTTGTAAGAGGTCACAGGATGGTGCTTGAGGCCGTGGCAAGC


TTCTGCCTGGGCTCCTGACCCAGAACAGATGGCTCCTCTCACCTTCCAGAGGTCTGTTCGAGGCATGGCTGGCAACGTTAAAAAAAA


TTTGGCCGGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACGAAGTCAGGAGTTTGAGACC


AACCTGGCCAACATGGTGAAACCCCGTCTCTACAAAAAATACAAAAATTAGCCGGGCATGGTGGTGCACGCCTGTAGTCCCAGCTAC


TCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAAGGCGGAGGTTGTGGTGAGCCGAGATAGTGCCATTGCACTCCAGCCTGG


GTGACAGAGCGAGACTCTGCCTCAAACAAAGCAAACAAACAAACAAACAAAAATCAGCTAAGTTATCCATGCCTCCAGCACCGTGGG


TGTTGACTCCCTGAAGGTCACTGGAAGTTGCTAGGGTCTTTCTGAGTCAATCCACATTTCAAGGTCAAATCTCCCTGCTCTGGGCTG


ATGAATAAAATGTGTCATAAATGCTCAGAAGCTCCCCCAGTGTGGCCTGGAAGCCTGATTTTATGGAAACTTACTGAAATGATACAA


AACGCTAAAGATATGCATTCCTAATTTTCTAGCACTTTCAACTCCACAGGGATGTTGGGGGAAGGGATTAATGAGCTTGGAGAGGTG


GAATAACCTCCTCAAGGTCTCCCAGCTGGGGGAAGGTAAGCACTGGATGTTGGGAATCACCAGCCTCATGTGCACCAACCATGTCGC


CAAATGTCCAAAGCCTGCAGAGGGCCCAGGGCTCTCACGGACCACACAGGGAAGCCACTGCACCTGTTCTTTTTAAGACTGGGAGGA


GAGTGGGGAAAGGCAGCAGGTATGGCTTTTGAGGTCCTCTCCTAGCCCAGCTGGTGTCTGATGCTGGCACCCGGGCTTGGAGGGTGA


GAGTCTTGGGACCTGTAGACCAAGGCCACCTCACTTGGGCAGCCCAGGCCTGCTGGACATGGGCCTTCTGACTTAGTTTCAAAGCTG


GACCCTGACCCTTGTTGGTTGCAGGACTTCAGTGATTTAATCTTTGAGTTTATCTGTTTCATTGGGGTGATGGTGCCTGCCTTGGAG


GAGTTTTGTGAAGTGATGTTAATGAAGGAGCTTAGGCCGGTGACTTGACACATGCCCAACATAAGGAATGCCTGTGGGGCCGCCTGG


CTCTGCCCCTAGAGTGGAGGGAGATGGTGCAGAGGGAACAGTAGAACTGGTATGGGCTGCGGATGCCTGGCGAGTGGCATGAGTAGG


GGAGAAAGAAGCGCCTGCCAGAATGGGAGTGAGGGAGAACAGTGGGGGGTCCCCTCCCTTACCACAAGACCTGGGATCTAACTGTGC


CTTTAGATCAGAGCTTCTCAACTGGGGCACTTTTGCTCCTCAGGGGACTTTTAGCAATGCCTGGAGACATTTTTGCTTGTCACAGTC


AGGAGAGGGATATTATAGTCCTTTAATGTGGAGAGGCCAGGGATGCCCCCTACAACAAAGAATTACCCAGCCCACAATGTCAGTGGT


ACTGAGGCTGAGAAACCCTGCTTTCGATGACTCATTCTCACCAGCTTGTTATGAGGATGAATGCGAAAATGGAGCCTGCATTTCTAA


CTGCAGCCTGCCCTTCCAGGTCCTCTCGTTCCCTCACCCTTTCCCAAGGGGGCTGCCTCTGTCATCAAGCAGCCTGGTCCAGGAGTC


AGCAGACCTGAATTCAAGTCCTGACTCCTCATGCCTCAGTGAAGTTTTTCCTTAGTTTCTAGTCTCCATGTCTTTTCATCCTTGGAA


ATCTTGTCTTGAGTGCGGCAGTGGTGTCTACACAGTAATGGGGCTGTGGTGTGGACTGAGTGGGAACCCGGATGGGAAGCATGCTTA


GTCAGCTGTGATGTGCCGGCAAAGGGAGGCAGCAGGCCAATCCGCTTTCTAGTCCAGCACTGAATAATAGCCTTGGGGGGCATTGCC


CAGGAACCCCCATTGGCCCCTGCGAGGCCACATGGCTGTTCTCCCAGGCCTGCTCCATCTTGCTTCTTGCTTGTGTTTCCTTGAACA


GGTGGAGCTAGTCTCCATTTGGGGAAGATGGAATTTGCAGGAAAATGCAGGGCTATTATTTCTGTGCTGTGTGAGTGGGAGACAGAG


CTGGTTGAGTGGCAGATTTCCTGGCAGGGGGAGAAACAGCTAAGTGTGCCAGCCCAGGCATCGCTAGAATCCTCTTGAGGTGAGTGG


GCCAGGATTCCCCAGTGGCCACCTCGGGAAGCAAACATTTGTTCTGAGCTCAGGACCAGCCCCAGGAAAAGATGGGGTTTGCTGTCG


GGGAAAGGTCTGTACCAATATATTGAAGCTCTGAGAACATTCTACTCGGCAAACTTTCACTGATGCCCATTCTGTGGCAGGCACTGG


CCCCGGGGACGTTGGGGGACACAGAGATGGATGAGGCTGAGGGGGTGTTCGGGCTGCCGTAACTCTGAGGCAAGGCAGACTGTGCTA


AGTGCGGTAGAGAGGCTCTGCATCCCGTTAAGGGCCTGCCGCGGATATTAATGTTTGGAGGCTTCTTAGAAGAAGTAGGGGTTGAGC


TGGGTTTTGAAGGAAGGTAGGGCTTCATGAGGCAAAAGGGAATGCGTGTTCTGAGCCGAGGCAACAGTAGGGGCAGAGGCTCAAAGT


TGGAGAGTGCCATGTGTTCTTAGGGAGGGCTGGAGAGGTAGGTTTTCCTAGAAGTTCTGGGAAGAGAAGACTGGAGAGGGACATGGA


GCCCCCTGCCCGTGAAGCTGGTGGAGTAGTGGGGGCTTCACGAACTAGGCTGATGAATTTGCACTTTTGTCTAAAGGCACAGGGAAC


AGTGGAAGGTATGTGAGCAGGGCAGTGGTGTGCTCCAGCCACAGCATGGAGGATGGGTTATAGAGAGAGGAAGCTGGAAGCAGTGTT


ACTGCGATAGTTGTGAAAAGGAGGAATGAAGGCTTGAACCCAGCTCGGGGCAGTGGGAAGGGAAGATATGGGGGGAGGTCTGGGGAG


GCAGGCAGCTTCTCAGGCTTCACCTTTCTCCATCCTGGGTATCTGAGTTGTGTGTGAGGCTCGAAGTGACTGTCGTGGCCCACTCGC


CACATTGCTCTGCTCAAAGCCCAGCCTTTTCTTGGAGAATGACAAGCAGCGAGCATCAGGCAGCCTTCTGGTCCCAGAGAACAGGAT


GGCACGGTGCCCACACCAGCCGGCACCAGCCACTCTGGCTGGGGAGGGGGGGAGGCCTCCTTCTGGAACTCATCAGCGCTGGCTTCT


GGCCAGGCCCAAAGGAGGTGGAATACACCCTCTTCCTGCTCGTTTTCAGAGATTTGGGAGGAGTAGGTATGGAGGACAGCAGCAGCG


TGCTGCAGCCGGCTACTCTCGGGTTCGTGTCGGAGCTGGGGGAGTGACTGGCTGTGCAGTTGGGCAAGTTGCCTGGTCTCCCTGAAC


TTCAGTGTCTGTGTTTGTAAAGTGGGCATTATGATGCTTGGCCCACGGGTGGCTGTAAGGGCATCACACAGGTGTAATTACGCAGGT


GTCATGTTCTTAGCTCAATAAATGGCCGCTGTTTTTAATTGTCAAGATATGATGATGGACTTGACTTGATGGGTGGGGAGAGGCAAG


ACCTCCTTGCCTTTAAAGGAGTTGAAGACTTGGGAAGCAGTTGGAATGGTGAATTCTATCTTGGGCGTGTTGGCTTTGAGGGGCTGG


GGAAAATCCTAGGATATTCAGAAGAAATCTAGGGTCTTCTAATCATGTGGTTCACATAAATGACCCTTACTATAATATCTATCTCAG


AGTCAACTTTTCAAGACACCAGCCTCCCTGCAGGCAACCCCAGTGTGGCATCAGGAGAGCGGGGTCTTGGGTCAGCATGGCCAGCCC


AGCCTCTGGCTTTGCTTGTGTCATTGGTGACTCCCCGTGGTCCTCGGTGCCTTCCTCCGTGATGGCATTTCCCATTGGCTGGCTGGG


CCTCTGCCCAGGGATCCAGCTGGGTGCCGGCCCAGCTCAGGCTCCAGAGAGGAAAGAGCCCTGGATCTGGGGCCAGTGACCTGATAT


TCACGCTGGCTCTGCCCCTTCCCTCTCGGTGTGGCCTGGAGAGATGTGCAGCCTCCCCGAGGGCAGGGGGGGGTAGTGACGAGGGTT


CCAGGAGATGAGGGATGTGAAAGCAGCAGCACGTGCCTGGCACACAGGGGCCCTGGTAGATGCTTGGCGGACAAGTGAGGGCAGGCA


GGGGAGGGGGCAGACAGGATTCAGGGAGGCAGGCCTGGGAGGAGCCCAGGGCTCAGGGAGGGGGGTGAGGGGTCAGGCGGAGCCGGC


TCAACTCCTGGCTCTGCCGCTTACTAGCAGGAAGACTCCGAGTCCGGTGCCTGCTTTGGTCACATCCATGTGTGGGTGGTGGCGATG


GGAGGTTGGCCTTGGGGGCCGCTCTAATGCCTACCTCACAACATAGTGATAGGTCTAGATGGATACACAGCACCAGGGCCTGAGAGT


GCTGAATAAACCTTCATTCCTCCTCTAGTAAGCACAGTAAATCCCTAGAGGGCAGTCCCCAAAGGCCTTGATTACCCCAACTGTGGA


GTACAGCGAGAAGTGGAGCTTCTGGAGCCAGTGCTTTCTCTGCTCAATTTTGTGTATTCTTTCACTCGTTCATCTGAAATCTGACCC


AGCCCCATGGAAACTGGCTGCAGACACCCAATGGCAGTAGGGTACCAAGGGGCAGGGGAGCAATCGGCTCCCGGTGCAGACAATGAG


GGGTACACTGTCTGTAGAGGATATAGAAAAATAAATAAAGCCAACAAAAAGTCTGGTTTTTGTTATTGCCGTGTACCGGCACTTCTA


AACAAGGTCAGTGATAAAACACTCCTCCTCCCGGGGGGCAGACGCTCCTGGCTCCCCCTCAGTATGCTGCTGCCTAATCGTCCTCCA


GAAAGGAGCCTCGGCGGCTGTAAATATCAGGAAGGAACTCAGCAAGGCCTGGCAGAAGAAGCCAGCGATGATTTGGAGAATAAGCCC


ATTGATGATTGCAATAGCAGCATGGATTTGGGGCTCAGGAGACCAGGAAGGGGAGGGTGCCACACTGTGAAGTAAGGGTAAGGCAAG


AGAGTGGAGGTAACTGCTGTGGGTTCTGGCTGGGAGAGGCATCGTCTAGGCCCTTTAGACGTGGTCAGGAAGAGGGTGTACTTCATC


TCCCTTGGGCCTGGCAGGAAGCCAGCGCTGATGGGTTCCAGAAGGAAAGCCCCCCAGCCAGGGCAGCCGCTCCCAGCTGGTGTTGGC


TGGTGTGGGTGCTGTGCCACCCCACTCTTTTGGACCGGCAGGCTGCTTGCCATCTTCCAAAGGGGACTGGCCTCTTGACAAGGGTAG


GAAAGGAGCCAGGGCTGCCCTATGGGCTTGGGCGCTGGTAGGGCGTTGGGGAAGGCAGGATTCACATTTCTCTAGCCTGGACAACAA


GCATGTGCCTGAGGATCAAAATGAGCACTTTTAGGGTTTTATTACTATTATTTACTAAACAAGTTTCCTTGCAGGGTTGTGGAAGGG


GCCCATGCAGAAGGATCTGTCTAGAGGAGGAGGCTCCGCATGTGTACAAGGGAAGGACGTGTGCCCTTGGGACTGGCTGGGGCACGG


CCCTAGGGAAGTGTGTGTGTGTGTTTGCGGGGGTGCTCTGGTCATGTGGCCCCTTCCCTGACTGAACCCCTTGCAGGGCCCCATGCC


ACACAGCAATGCTGCGTCCGTTGCAGAAGCAGACACCTTTGGCTCCTGCTGTGTGGGAAGCAGGTGTGCATTAGTCAAGGTGGCCTC


AGTGGTCCTGGGTAGTGGGGCCCCCGCAGTGAGAAAAGCAGAGACCTCTTGGGCCCGGGGGTGTAGGAGTCACTCTCCCTGATCTGC


TCCCAAATGCAGGTGCATCTGGTTCCATTTGGAGCCGGTGAGCTGGCTGATGGTGGCTGTCTGGGGCTCCTGGGGCTGAGCAGCCAG


GCTAAGCTTAGCCCACAGGCACTTCCCAGAAACTGGTGGCACTGTCACAGTGTTGGCTGGATGCTGAGGAGTTGGCAGGATACAGTG


CAGGAACAGCAAATAGGTTTTATCTGGGTGTCAAGTTGAAACAATTGGTACCAGCTTCCAGGAGGACTGTGTTGGGAAGGATTCTGA


GGTGTTGTCTGAGCTCAATGGGAAGAGTGCCCTGATTGATTCATGAGGTCTATCTTGGGCAGGGGAAATGGAAGAGTGGCAAGGGGT


TTGCCGTCCCTGGTGTAGTGGAAAAAATACAGAGAGCCTAGATTTGATCTTAGGTGAGTGGCCCCAGTTTTTTTTCTCTCTCTTTTT


TTTTGTTTTTTGAGACGGGGTCTGGCTGTGTTGCCTAGGCTGGAGGGCAGTGGCACAATTTCAGTTCACTGCGACCTCCACCTCCTG


GGCTCAAGCCATCTTCCCACCTCAGCTTCCCAAGTAGCTGAGACTACAGGTGCCCGCCACCATGCCCAGCTAATTTTTGTGTTTTTA


GTAGAGGCGGGGTTTCACTATGTTGGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCCAAAGTGCT


GGGATTACAGGCATGAGCCACTGCAACTGGCCCCCTAGTTTCCTCATGTCTAAAATGAGGGTAAAAATGTGGCCCTTCCAAGCCTTA


TTGTGGGCGCTGAGTAAGATAGCAGAGCGAAAGCCCTTTGTAAAATATAAAAAAGCGATACAAACCCAGAGTGGGGGTTTTGTTGTT


ACTGAGTCTCCCAGGAACCTGGAGTGACTTCCCAATAATAACATCTGCCCCACTGGGGACTACTCCATGGTCTGAGTGCCTGAGAGG


CCTGACAGGATGTGTGACCGGCGCGGTGCCCGGCACCCAGGCCTTTGACACCAAGTGTCAACGAGGTGTTTGGTCATGTTTCCAACT


CTAAGTCACTTCATTTCTGTCTGACTCTCTCCCTGGCTTAAGATTTAGAGACTGTTTTCGTGTCTAATGAAAGAAGCACAGAAAATC


TCTCTCTAGAACCTTGTCTCTTACTCTCCATTAAAGGTAGCAAAATTGCTTTATAAAGTCTAAAAGCCTGACAAGAACGCGTACTAA


TAATGCATGAATTATGCAAATCTGTGTAGTCACTTGATTTGCATAATGGAGGGGCTGGAGGAGGGTTGGGGAGGGGAAGGAGTGAGG


GTGAGGGCGTCTGCCCAGATCTGTGTGTAACGGGGGACATTCATTTGCTCCCTTGGGTGGAGTCCCCTTCTGCAAGCCCCTGCTGGT


CCCGAGGGTGTGTTCTTTGGCCTTCCCCTGCTGGCCTGGTGTCTGCCCTTTGTGGCCTGGCTGTGCAGCCCCCCCTCCTACTTTCGG


GGCAGTCACCGAGGCAGGGGCACCGCACCCTGTGCTGGACTCTTGTGTAGAACTGGCTTCATTAAATCTCACAGCCGCCCCTCCATG


TCCAGACAGCCTTCCCTGAAAGTCCCCTGGGTCATTATTTCTCCAAACGTCTGTCTTGCTGAGGCATTGGACTTCGTTAAGTGCCGT


CTGGAATTGTAACTATTGCCAAGTGCCTTTTTCTTGGGTTCTGTGGGAAGCAAGGGTGAGAAGGAGTCTCCGGGAGAGAACTCCCCA


CCTACCCCGCCTGGTTTCTCTCTCAGCGTTTCTCACTGTTGCTTTAAAAGGTTTCAGCCTCTGCTGTAAGGGGCCTCTTGCTTTTCT


CTCCCAGCCTCCCTGCATACTCGCTAACCTTGGGACTTCAGATTTGATGAGGGGCCGGGCGCAGTGGCTCACACTTGTAATCCCTGC


ACTTTGGGAGGCCGAGGTGGGAGACTTGCTTGAGGCCAGGACAACATAGCCAGACCCCATCTCTATTAAAAAAAATATTTGATGAGG


GCTGAGGCTGGGACTGAGGATACTTGAGGCTTGAGCTCAGTGGGTGCTGCCTGGAAGCCCGGGGATGTGGGCTCTCAAGCTGAAGGG


ACGCTGGGAACCAGCTGTGGAGAGCCAGGCAGCTGGCTTTTTTGTCTAGAACCTGGATGGGGCAGCTTCTTGTTCTGGGGAGGGGAA


CTGTTCTGCAGGGTGGATGGATGCAGGGAGCCAGCCCTGGTTGGGAGGTGGGAGGGGCAGGGACCATATCTAGCTCCTGGAGAGGCC


AAGCAGACCGTCAAGGCTACAAACAGGCTGGGGTTCAGCTTATTTCAACATACTTCTTCAGCATCTATGTCTATGGGCTGGGCTTGT


GCTAGGCCCTAGGTGTCAGAGATATGAAGGCACTCATAGCTGTCATTTATTGAGCTCCTATTATAAGTGTCAGGTCCTTCGCTAAGC


CACTTATTTACACGTGTCATCTCATGTAATGTGTATGACAACTTTATGAGGTCACTACTCTTACTGCCCCATTTTATAGATGAGTAA


GTTGAGGCTTGGTCACATGGCGAGGAAGTGGCAAAGTGGGGCTCTAAGTGAGGTCTTCGGACTCCAAAGCCCCTTCTGCAGACCGTG


ATGCTTTGCTGCCTCTGTTGAGTCAAACCGGACTCTTCCCTTGAGGCCCTGATGGTAACAGCAGTGTAAACAGATGGTGAGCACAGT


GTAGTGTAATATATGCAAGGGGAGAGGTTGGAACCAGGCACAGAAGTAGCACTGAGCATTTAATTATGTCAGGGAGGGCCGGGGAAA


GCTCACAGAGGAGGTGGTGGGGGGGGGGGTCCCTGAATGAGCCACAGGAGGGAAACCAGATTCTGTCTGGCACTTAGGGAAGCAGCC


AGTGGAGGCTGCAGGTCAGTGGGCTGGGGTGAGGGGTAGGGGCTTTAAATCCCAGTTGCTTATAGCCCCCTTCTGCCCCACTTTTGG


GGTGCGACCAGGTGATGTGAAGCTCAGGAGGTCATGGCTGGGACACTCAGGAAGGTCAAGTGTGGGGTGCTGCCCCACGGCCCCTCT


CCTCGGCCTGTATGTTCAATAGGTGCACTGGCCTCCCTGTCTTGGCCAGACAGCTCTGAGAGCCAGGGCTCTGTGGGTGCCTGAACT


GTGTGTGGACCCTGCCTCGGATGAGGCCACAGCTGCTCCCACACCCGCACCTGCTCACACCCAAGAAGGGGGCCGCCATGATCACTG


TGGAGGCCAGGGTGGGAGAACCCTCTGGACCATAGGGTCCCACCCCATTGCAGGGCAAAGAGGGGATCTGAGGCCCAGTGACTGGAA


GTGATTTGCTGCAAGTCACACAGGCAGCAAGAAGTGGGTCAATCCCCCAAGGTTCTGGTTTGGAGCACTCCCGGGGGTCTCCCCTCA


CCCCTTACCCTGGGCTCGCCCTCTCCAGGCTGTGTGCCATCCTCACCACCTCTGTCGTGCCCTCGCTCACCCACGTGGCTACACTCT


CGCGTGCGTTTCCCTCACACCTGGCCATCCTCTTAGGCCAGGCCAAGGCTTTGCTCTGGAGAGAACTTAAATGGCATTGTCAGATGA


GGAAGGAGCAGAACCTGCCGATCCCATGACCTCCCAATAGGCCATCTGCACACACTCAGCCCGCTCTCCCCAGCCCTGCACAGCCCC


TTCGGCTCGCACATCTCATCCTTACTCCTGCTAGCAAGCAAAGATGTCTGCAGGTGCTCTCATTCGGGGATGGGGATGTAGTAGGGA


GACAATACCTGGTAGATAGAGCTGAACAACTTTCTGCAGAAAGTTTGGAGTGAGGGGGGCTCTGTGATGGAATAACAGGCATGAACC


AGAAGCCTAATTCTATTGCTTAGAAGCTGTGTGGCTTTAGGCAAGCGACTTAACCTCTCTGAGTTTCAATCTCCTTATTAATAAAAC


AGGTACGAACAGTGCCTTGCTCAGTGGTCCCCTAACTTGGCTTCATTTTGGAATCCCCTGGGGATCTTTAAAAAAATGCTGATGCCT


GGCTCCCAGCTTCTGACCTGATGTCACCGCCCTGAGGTGCAACCTGGGTGTGGGGATTTTAAAAAGCTCCCTGGGTGATACTAATGT


GCCGCAAAGTTTGGGAACCACTGTCCCAGGGTTTGTTGGGGATTAAAGGAAGAATGCAGACACGTGGAGAGCGCTTACTAAATGGAG


GTGATTATTTCAGTGTTCATCTCCCTGCCTCTCACTCCATTTAATGTGGAGTCTGTGGGACTGAGGTTTTTATTTTTATACCACAGT


GGGTTTGCCAGAGTGCTGACCTAAGGGGGCTGTCAGCGGCCCATCTTTACCCGGAAAAGCCCCTCCCTTGCGCCCTCACCATCTCTG


CAGCCCTAGGGCAGGCCTCAGTCTTTCTGACAGGCCCCAGGGTCCTGATTAGGCCGGGGCCTGACCCCGCAGGGGCAGGCCTGCCCC


TGGTCTCCACCTGGTGGCTTTGGGAATGGAAATGCTGGTTCCCACAAAGGCTTCTGGGAGACAGAAGCCTAAGATGGCAGGGTGCGG


TGCACACACTCAGTCTGGATTCGGTGGCCTGACCTGGGGGATCCGGGGAGGGCGTTGGTGGGGGCAGAGGCGTGGGAGGGGCTGCTT


CTTTGGAGCTCTCCACTCTGCTCCCTGGTACTGTCTGAGGCCCTGCAAACCTGAGCAGAGCCTGTGAGGGAAGACACATTTCTCCAG


ATTCCTCAGCTGTCCTGACAGGAAGTTGTGCATCACTGGGCTGACAGGAAGGAAATGGCTCTGCTGTTTGGAAAGAAATAGAGAATT


CTGACTGGGGCTGAGGGAAAAGGTGTCTGCTTGGAGAAGCCGTTTTGTCCCGATATGAGGACTCTTTGTCTCTGCAGGCAGTTGCTC


CCTGTTTATTTTCCTTTGAATGACAAGGATTGGCTTCAGTTAATGAGGAGCGGTGAGAGGAAAGTGAGAAGCGGCTTGTGAGATTTT


GGGACACGGAAGCCTTCGCAGGAAACCTGGCCCTCTGCTTGTAATAAGCATCTTTCTTTCCCAGCTCCCTGCTTCGGGGACTGTGAG


GTGACAAAGGATTTTGTGATCTCACACGCCGCTTTTTCTCCATCCACCAACCATACCTTTGCAAATGCTTTGATTTCTATTTCTTTT


TACCACCCCAAAAACACAGTGGATCTTTTAATAGCACAAGGCCTTTTGAATCTCTAACCAATCAGTCTCCAAATCCTATCCAAAGTG


CACTTAGAATAGACACTTTTAATAAAATATATTGCTTTTAAGCCAGTGTAAACCTGTGAAATTTGTACATTTCTTTTAGAGCATCTC


TACAAATTTTACATTATTGAAATCACCACCCAGTGACCTTTTAGGAAATACTAGATAAATTGCAAGAGACAAATAGACAAACCAAAT


GGAGTAAGTACAATTTCCAGTGCCTTTCCTGCTAGGTTCCCAGTCTGAGTCTTAGAAATCCCTGACTCCCTGTGCCCCTCCCCCCAG


CTCTGTGACCTAGCCCCTGCTCTGCAGGCCTCTCTGCCCACCCTGCCCCTGGCAAGGAGCTAGCAGCTGGGGTGTCATCTGAGAGCC


ATTTGCAGCTCTGAGAAGCAGCTCTGGTATGTGGCTCCTGGCACCTTGTCCCGTCTGTGTTTGTCTCTGCGCTCCATCATTCAAAAC


ACTTCCACCAGTGGCCAGGGCCCCCAGAAGGGCTCTTGGGGGTGGCTGAGGACTGCTTTAGAAAGGCTCAGATGCTCTGTGGCCGAG


TCTGCCCCAGGCGAGGTCCTCAGCCTTGTCGAGTGAGAGCTGAGCGGGGGTCTGAGTCCAGCAACCCTCACTCACTGTGGAGCACTC


TCTGTGCCTGGGTCAGCCAGGTGTGGATTATCCACTTTGTGGATTGCCTGTAGTGTCTTTTCCAAACCCAGGTCACGTTCGTCCCTG


CTGCTGTCTCACTGCATGGGGACCTTTCCTCCCTATCAGCTGGTGGTGCTTAGGGGATGTAAATCAGGTGTCGTATCTTGTTTGTAT


TTTGTACAGGGAAAACAGAATTTGGAAGACAGATGGTCTCTAAAATCACATTACCAGAGCCTCCAAAGGGTCTCCTGGAGGCTCAGT


GCTCCTTTGGGCTATGGGATCTGTTCCCCTTCTGGTGTAGGTACGCAGAGCCTTGGAGCAGTGATGGGGGTGGAGGGAGCACAACTG


CGCCCTGCTTCCTGAGGTCTGCAGATCGCAGGTCACTCGATGGTGGCGGGCACGTGGTTATGCACTCATTTCATGGATAAGTGAACT


CAGTCACCATCTCAGCTGCTTTGCCATCGCTACACAGCGACCTGTGTCAGCACCACAACTGGGAGTGTTACTTGGGTCCCCTGTATC


TCAGTTGCTGTTTTTCCCATGGAGTGACCCGACTGCCCTCCAACATGGGGAGGGAGGGAGAGCAGAAGGCAGATCAGCGGTTAGAGA


TGTCCTGAGTGGCACTGGCCCTTCTGTAGGTAAAGTAGCTTCGGGAGAAACAAGGTACTGTCAAAGCTGCCCAGGCTTCATTCACTC


CTTAATTTGATAATTAATTCCACAAACATTAATGGAGTTTTTCTCACATTCCAGGCACTATGCAAGGTGCTGGGGGTGGGGGAGAAA


CAGAAAGATGACAAAGACTTGGTTCCCACACTCAAAGAGCTCACAGCCTGGTAAGCAGATGCTCAACGCACTTAGAATTGTCTCCCG


AAGAGGCCTGAAGGGACAGGGTGGAGGAAGCGCAGAGGCGGAGGCAGCTCTGGAGGGTAGGGTGGTGGGAGTGGCGAGAACGGAGCC


GGTCCTGAAGGTTGACTGGGAACGGGAAAGGCTAAGGCAGGGAGGTTGTTCCCGGCCCAGCAAGCACATGGAAAGGTTGAGGGAAAC


GAAAGCTTAGTGCATTTTGAAGGAGTGTGAGCAACTCGGTATGGCTAGAATTTATGGTGTGAGTATGAGATATGGGGCTGTAGAGGC


AGGCAGGGGTCAGATCATGCCTTGCTTAGGGGGTCTGCCTTCATCCCAGAGGCTGTGGGGAGCCGCAGAAGGGATTTAAGGAGTGGG


ATGGCACGATTTGTGTCTTAAATTACTTGCTATGGAATCTACATGGTATAGCAGAAGGAGCCCGGGAGTAGGGGAAGGAGCTAGGCT


CTAGCTCTAAATTCTAGATCTGGATCTAGCAGCTGGGTGACTTTGGCCAAGTCGAGGCCTCAGGGTCCTGACCTGTAAGATGCAAAG


ACTCTAAGGTCTGTCTTAGCCCTGACGTTCTCCACACCCGTGGCCGCCTTCCTGTTTGGCCCCCACACTCTCTGTTCTGTACTTGTC


CATCCACCTCTGGCCGCCTGACCCCTGTCAGCTGGCTGTCCCACCGTGGTCAGCAGCTGGTGGCAGCTGGAGGGAGAGGGGTGAGTC


CTCCAGGAAGCATGTGCACTCCTGCCCTCGTAATTCAGGCCTGCCTGGCTTCTCCTCTTCCAGCCCTGCGAGAGCGCCTTCCTCCCC


GCTGACCTCAGCACACCTGGCTCCCCACGGCACACAGCCCTGGCTGGGCCCAGCTGTGTCTCTTCAGTGAGACAGTTCACCCCCTTG


GGCCAAAATCCCCACCCACCTGGCCCCCACGTGACAAGAGGCAGCTGCTTCGGGGTTGCCACCTGGTAGCCCGTGACATCTGTGAGA


TGTCTGTGCATTTGGCTGGTGTGAGCTTTTTCCTTTGCTCTGACCCAAGCTTTGATAGCTCAGTGTGTCATCACCGGCAGTGGATGC


CTGGGAGCCCCAGACTGGCTCTTCCTGCCCAGGGACCCCCAGACCCACTTCTGCAGGACGCCTTGAAACAGCTGTGGGTGGAAAGCC


AGGTTTTCCCCCATAAGCATCACTCGTTCTGCTGCCTTCCTAGCTTCTGTGCTCTCGGGCCCAGAGCTCCTCCAGGGTGAGGAACCA


GGAGGAGGAGTTGGCTGGGTTGGCTGTTTTCCTAGGTCTTTGATCACAGCTGTTACATGTAGATAGGCTGGGCGCGGTGGCTCATGC


CTGTAATCCCAGCACATTGGGAGGCCGAGGCGGGTGGATTACGAGCTCAGGAGATCGAGACCATCCTGGCCAACATGGTCAAACTCT


GTTTCTACTAAAATGCAAAAAAAAGAAAAACACAAAAAATGAAAAACAAACAAACAAACAAAAAACTAGCCGGGCATGGTGGTGGCG


TGCGCCTGTAATCCCAGCTATTCAGGAGGCTGAGGCAGGGGAATTGCTTGAATCTGGGAGGCAGAGATTGCAGTGAGCTGAGATTGT


GCCACTGCACTCCAGCCCAGCAACAGAGCAAGACTCTGTCTCAAAAAAAAAAAAAGGCTTAAACAATGGGTTCTAAGCAAATAAGTA


TCTGTTTAGTCAGTGGAACGAGGAAACAAAAGTTGATGGAGTTCTCCCCACAATTGGAAGTGTTGTTCCCCACCTAGATGATGGGGC


CTGCAGGGAAGTGATTTTGCACGATTCTCCTCTTCTTGGGAACAGGCCATAGGGTAGCATCCCTTCATTCATTCATCAAGTATTTAT


TGAGTGCCTACTGTGTGCCAAGTCCTCTGTGAGGTGATGGAGCAGAGAGACAGAAAGGACCCCGACTGTGCCATGAAGCAGCCCCGA


GCCTGGAGGGGCCACTCAGAGGGAGCCCAGGGGCGGCGGCTCTCGGGCTCCAGCCGAGTTTCCTTCAGACCTAGCCCCTTTAGCTGA


CAATCTTAAAGCCTGGTCCCGGAAAACAGGAATAGTGCGAGAGGGATGAAATGTGGGTGAGGAGAGTGAGACAAGGGTGGAGGTAAG


AAAGAGGGATGGAAGAAAAGACGCAGCAAACTTTCCCGTGAGAGAAACGCTCCAGACAGCACCCCAGTTCCCAGCTGAGACTCCCAG


CCACAGTCAGCAAGAACCCACAGGAGGGGAGGCCCACGTCCCTGCTCAGCTCTGCCCTGGCAAGTGGGGTCGGAGATGGGGCATTCC


CTGCTTGGGGTCTCAGTCTCTCCATCTGTAAAACGAGGCTTTGGACTAGGGGAGCTCAGAGATCTGTTTAGAACTAATATTCTGTAA


CCGGTGCAGGGCAAAATAGACGGGGGGCAGGAGCCCAAATTAAGGCCAGTCGAGTATCAGGTGGGGTGTTCCTCTGGCTCCTCCTAT


TACAACAGCAAGAGGGACCCAGGGGTACTGTGGGAGTCCTACCATCTCCTCACTTGTACGAGGTACCTTCTGGCTGCTCTTCCGGCT


GCTCAACACTCAAAGAAGGAAGGTGCTGGGTGTCCTTGTTTGCATATTTTTCTGGCACGGACACATTCTTCTTGGAGTTTCTTGACA


TTAGGGCCACTTGAAATGCTCAAGGTAAGGGCTGCTCTGCCTGGCAGACATGCGTCAGGTGCCTTTGGCTCCTCCCTGGCAAGTCTG


CCTCCAGACGCCCTCAGATCCTGTCCCCATGCCTGGCCATGGGGCTATCTGACCACTGATGCCAGAGGGTCACACTCATCAGTCTAT


ACAGAAGACTTGGAAATGTTTTGGCAACCCTGTGTTAGAAGAGTGGGGTTTCCTAACTGTATGGCTTTGGGTAATTGCTTAAATCCT


CCCAGCCTTAGTTTTTCCATCTGTGGGTTAGGAGTGGTCCTCTCTACCTCCCAGCATCAAATAGGAAACTGTGCAAGAAAATGCTTT


GTAAACAGGAAAGCCCTAAACTGACATCCAGGACACAGTGACTCAGTAGCAAATATATTCTGATATTCAGCCTTTTCCATGGTTACA


GCCTCCTCTGTGCCAAGAAATTCAAGTCACCAAGGGTTAAAGCAAGCAAGGCACATGGCCGTGATTGTCCATAATTGATGAAATAAA


CCTTAAAGGAGTGACATATAATTAATTGCAATTAATCCAGGCACTGTGACACCACCTTGCTAAAAATACTGTCTACTAACAATTGCT


TTCATCCAGCAGAATGATGTCTGCCCATGAGCCTGGCAAAGTGTCTGCTAATGGAGTGCACATAGTGGGTGTGGAAGCTGGCAGGTG


TGGGGGCAGAGGGCGGGAAGGGGGCCCCAATTCTCTCAGACCCTTTGGCAGCAAATACTACATATATAGGGTGATCATATGATTCAT


TGTCTAAACTGGGACACTTTTGAGATTATTATATTAATGATTACCATTCATAGTAATAATTATGCCAGATAACAGGCATACACTGGA


CTCTCCTGGGTAAACCCGAATGTATCGCCACCCTCTGCATAGGCTGTTTTAAGCCCGTGGGAACCCTCGACTGGGAGAGTATTTTCA


CGTTCATTATCTGCTCTTCCTCACAACAACCCTGGAAGGAAGAAAGGATTTTTTAGTCTCATTGAATAGATGTTAAAGATGGTGATG


GTGTCAAACGGTCCAGCTCTAGTCTTTGGCCTGGCTTCCTCGGTGGCTGACCCCATGCAGGTAGAGGACAGCTGGTCAGGACCGGGA


GTTCTGGGGATGTGGAAACAAGTGCAGCTCAGGGGGAAAGAAGTAGCAAATCTGGCTTCAGTGGAGCAGGAACAAGCGACCTCCTCC


GTGAAGAGCTCAGGGTGTAGGTCTCAGCCGGGACTGTGCTGCGGTCCTTACCAATCCTGGGCTTGGAATCAGAAGCTGTGTGTTTCA


AGTCTGGCTCCCACAGTTCAGCTGTGTGATCTTGGCAAATTGTATAATCATTCCGTGCCTCAGTTTCTCATTTGTCAAGTGGGGACA


GTTCCTTCCTGTGAGGATTAAGTGAGAGTTTATATGAAGATGGATGGGTAGACTCAGAGCCTGTCATATAACAGGTACTCAGTAAGT


CCTTGTAGAGTTTGAATCTGTGGAGAGTTCCTAGAGGCAACACCTGTAGGGGAACCATGGAGATCCTTCTGCCTTGAAATGGCTCTA


ACTTGAACCAATTAGTGTGGAATGAGCTCCCGCCTTGAGATGGGGCTGCCTCATGTTCTTGGAGAAAGAAATGGAGGAAATAACCAC


ATGGAGGAATTGGGAGGTTCCCTGACCCCCCCTAGACCATGGATAGTCTACTTGGGAGACTCTACTGCATGCCCCGTGATAGGCAGG


ACCAGCACCCAAGGAGTCTTTGCATCTTGCAGTTTCCTTGAAGCCCTGTACAGGCTGGTGGCCCACGTTGGTGTGTGGCTTCCAGCC


TTCCTCCAGGCTCTCAGATGAACATGCTTGGACATGGGCAGGCAGTGGGGCTCGTGTCGTGCCCCATTGCTGGAATTCATGGCACCT


CAAAGTAAAAGGTAGGCAGGTTGGCAGCAGTCTGGTGCCAGAGAGCTAGTGAGAGAGAGAAAGAATTATACAAGTGCCATGTTTGGT


CTATTAATAGCCTGTGTTTGGTCTCCACCACTTCTATCAACATCGTCCATCACATCCAAACAATTGAAAAACCTGTGCCAAATGTTA


GGAAACTCACGGCTGTGCTGTTTCTGAAAAACAGCATTTCTACTTCTTATGCCGCACTGAGATGCCAATAGTTCCATGCCAACTGGT


TTTTATTTTTCCAGACCATTTCCCTTTATTTATGTTTAAGCTTTTGTATTGTTAAGCCAAAAGAAGATAGAGAACCTGGAGTAGGTA


ATTATTGTTTCTCCTGATTTGTCCTTGAATGAGGCATGGAGGAAATGTTCACTCCCCAAACCTGAATTGAGTAGCTGCAGAGGGGTG


GAGAGAGGACTAAGACAGGGGCCTGTCCCTTTCAGACAGTGTTCAAGCTGGTGGATGGGCAGAGTGAGGATGTGGCAGAACACCAGC


CCCACCCTTGGAAGGCTTAGGGCATTATCAGCCCTTTCTGTTACTGGTGTGTGGCCTTGGGTAGGCCAGAGTCCCTCTCTGGGCCTT


AATTTGCTTGCCTATAGAATCGGGGAGTCAGACTTGATGGCTTAGAAGGCCTCTTCCAGCTAAGTCGAGTGTTGGGTGGAGGACTCA


CTGTCTCACGTTTGTTGGCAAGGCCGTGGGTGTGGAAATGGAAGGAAGGTGATGCTGCCCTCAGAATGCTGGCAACTCCGGGAAGCC


TGGAAGCATGGCTGGGAAACACGGACGAGGCTGTTCTTTATCTGGGAAACTCCAGAACAGCCTCCAGAGATGTCTGTGGAGCCTGCA


GGCGGTTGTTTTTCTCACCATATGTGATTTCTGGGTGTCTTAAAAATTTTCATTTGGCCCAAACATTGCCGGGGTTGGGGGATGATT


TTGCCCAGTGTGGGGATGGAAATGGGTTTGCCTCTGAGCATCAGGTGGGTAGTAGTGGTTTTCTCCATTTTGGAATTCTCTGACGAA


GTTGGAAGGTTCAGCTGGGGCCCTAGTGTTGCAGCAGCTTCTGGTGCAGACAGAGGCAAGGGCTGGAGGGAGGAAAGGGGGAAGGCC


AATTGGAGGGGTGATAAGGCTGAGAGACCCAGGGTGGGGAGTTGTCTGTAGGCCTTGCTTTGTGTCTTTAAAACCCACATACCTCTC


TGTGGCTATCAGGTGATGAAAATCAACATTATTTCAAGTTATAGCCATCTGAAATGAATGTAGCCAGTTCCCTGTAATTAGCTGACC


ACAGCTCCTGCAGAGAATCTGGGAATCTGTTGTGCGTCTTGTCAGCGATGGCTGGGGCAGGATGGGGAAAGGGAAGCCCAGGCCTGG


GACAAGCCCAGCTAGGCTGGTTTGGTTCTAGTCAGCAACCCAGTCTAACAGGGAGCCCACAGCTTTCTGTAGAGCAAAGTGATTTCC


TGCTGTTTTATTCATTTGGGAGCCAGATAGGTTTTACTAAGAGAAAGCAAAACTACTTCAAAGCAAGCCATCCAGAAAGCACAATTA


TTTGTTTCAAATATTCTAGAACATTTAAGAAAATGGGGGTTCCTGCAATCTGGATGAAATATGGGGGCCAGATCCTTGGCAGGTGGA


GCAGTAAATATTTGCTAGGTGAACCCCTCATGGTGATGGCAAATTGACCAGCGTTCTGGGAGGCGCTAGGAGGGTGAATAAAGGTTA


AGTGTTTCACTGTAACTCTGTACACCCTGGATGCCAGGACAGATCTGGGGGCTGGGACTAGGAACCTTCAGTATGCTATACAGTTCT


CCTGAGATAAAGGTATGGTGTCAGGACCTTCAGAACCTGATGCATAGTGGCAGGTACGCATTCATCAAAGCCAGAGGAGGCTGTAGG


GACTTCTTGACACCACAAGAGTAATGTAATTGCTAACTGGCCAAGAGCACTCACATTCCACAAGCAGAGGAGGCTAAAAGCTCATCA


GGAGCCCATTTTTTTATTGGAGAAGGAAACAGTGACTAAGTGACAGTCTTGGAGGTGACTTCCAGGATAGGGATACAGGCTTTTGGA


GAACAGATGAATTCAGGGACCGGTTGTTATATTTCCGTTAGTATGAAAAGCAGGGTGGGCCGGGCTGCCTGCCCCTGTAAGCATAGG


CCGGGAGCCCCAACACCTGGGTTCTAAAGTTTTCTCCAAGCCAGGATGCTGTATGATGGGGGCAAGGCAGCCTCAGTGTCATCGTGG


AGAATGAGGGTTGGGGAACTAGCTGATCTCCTGGTGTTCTGTACGTTAATGAGTGTGTGTCCCAGGGAGAGGCTCACTTGTCAAAGT


CATTGACATAGACACCGGGATGCTAAAGTCAGAGCAGGTCTTCACAGAGGCATTTGTTTCACTGGGACCAAGCACTGCAGGCAGATC


TTTGAAAAAGAGCCATCCAAAATAGAGTCTCTCCAGGGCTACATTGAGAGGAAGTGAGTTTCCAACCCCTGGAGAAAATCAAGCAGA


GACTGGATGGCCATGTGCCAGAAATCTTAGGAGACTCATGGGGCACTGAACTAGATGGCTTCTAAGCTCCATTGCTTGTGTGTATGA


CTGTCTGTTTCACAGTGTCTCAGAGCTGTGAGGGCAACCCCAGCCTCCTGGCTTCTTTCTTTGTGCCCCAGAACAGCAATTCTCATT


TCTGGCCCGCACATTAGATTCACTGAGATCTTTTTTTAAAAGTTAGTGCAGAGACCTCACTTGCAGAGATTCCAATTTAATTGCTCT


GGGGTGGTGCCAAGCCCCTCAGTTCTACAAGGACCCGGGCTATTGGTGCTTGATGGGCTTCCATCCCACCTCCATCCTCCCTGTAGG


GGTGGGGAGTTACAAACCCTTCTGCTCCCATTCTGCCTTTGTATGGAGCCCAAAGGTTTAAGTCTGTATTTACCGTTCCATATTCAT


TTACCCAAGAAACACTTGTTAAGTGCTTGCTTTGTGTCTGCAAGAATCCTAGGTGGGCCAGCTTTTGGCTACCTGAGGAGCAGCAAG


GACCAAACTGCCTTTAAAAAGGCCTCATCCTGTATGTTTCCACCTCCCGCACAGTGCCTGGCACATGGCAAACATGTAATAAAAAGT


TTGATTGAATCGCATGGAATCTTTGCCAATATTGTAAGTGGGGCAGGAAAATAAATTATAAGCAAGCATGCAGTAGAGAATTCATGA


TATGCCAGTTCCCCTCTGCCCAGACCTTATAAAGGAAACCATCTCCTTAATTGGAATTATGTTTGTGGCCTGAAGGGGTGCCCCGTC


TGACTTGATATTTTGGGAGCGTGGTCTCCTAAATGACCTTTTTCTGCCTTCCTTGGGACATCACACAATGGGAGAGCCAGGGCCTGG


GGAGGATCATTTTCTCTTAATTGGTGTCCTGGTCATCATGCTGGCTTCACTAAAAATTAGTAGGCCACCCTCTGCTCAGACCTGAAT


GCCCTTGTTATTAACTGCATGATGTCCCTCAGACATCAGGTTCCGTCTCCTTCTGGGAGTGGCAACGTAGAGATCCAGGGAAATGCT


CCAGGGCAACTTGACTTTATGAGTTTTGTGTCGAGACCACTGGCTTCCTTCACGCCACAAGTATTATCTGCCTAGTTTCCCCGTGCC


GGGCCCAGTCTGCAGAGACGGTGAAGACCCCAAGCCCTGAGCTCAGTCTGTTCACCATCTATCACACCACTAAAGCCACACAACTGG


GGGCTTCTTCAGAGAGCAGGTGGGACCGGTAAGGGCAGGGCCTGCAAGGGTGATGTTCTGGCAATTGCCATCCTGTCTTCCTGAGGT


TCCCTCTGGATCAGTGGTGAGAGCACAGGTTTGAATCTAGCCCCCACCTCTTCCTCATCCAGGGACGGTGGGAATGTGACCCTCTCC


AGGCTTCAGATCCCTCATCTCTAGAATGGGGCCATGGGTTGTTCTGAGGACCTAACGAAATTAGCACAGTACCTGGCCTCTGGTAAG


TGAATAATAAATGTTAGCTGTTACTTTCATCACCTCTCTTTAGTTTTGATGAATTTGGAAATTCAGGATGGAAGTGTCTACCTGCTT


GACATATCTCAAAAATTTTGCTCCCTTCCTTCAAATATTCAACGTTCAACTAATATTTATTGACTTACTATGTGCCAGACCAGTGTT


CTAGGCATGGGGCTCTAGGAGTGAACAAATGCAATGTAAAAATTCCCTGCCCTCTGGGGTTGACACTCTGGTGGGGGTGTGAGAACA


ACATCAGTGGGAAAATGGGGTCAGATGGTGAAAGGTGCTCTGGTCACCCCAGCTGGGCAGTGCCAATGGGAGACACCAGGCATGGCC


AGCCTCGGGAAGGGTGTGGGGCCCAGGGCAGACCAGCGGCGTTCCTGGTGCTGAGGTTACCCTGTGTACTATTAAAGCAGGTAATGG


CTCCCAGCTTCGATGGTGGGTATATGGACCCCGTTCAGGGATGGGGGCTGAGGAGGGCACACGAGGACTGAAGACAGGGCTCTGAGG


AGCCACCTGCTCTCGGGTCTAGGTCAGACCCCGCATCCTGATGCGGGTCAGCTGGCTCATGATGCCTGGCTGGCTCCTGGGACTGAG


AGGAGAGTGTGGATGGTCTTGTCTCAGCTTTCCGCCCACTGGGGATCCACCTCAAGCATCCCCTGGCTGTGGGGTTGAGGGGTGGGC


CCAGAACAGAAGCTTCATGTAAGAAGGTGACTGGGCTGGAGAAAAGGTGGCAGTGAGGTTTAGCCCCATCTCCAGCCCCTGGGACCT


GTGGTAAAGATGTCCTCACCCACACAGTGGGCTCAGGCAGGCAGGAAAGGTTCCTGGAGCTTCGCCTCTAATATCCATTCTTGAGCT


CTGCCGTGGAGAGAGCTGGTCACTCGAGCGCAAAGGAACCACTTGTGGGTTTTCTCCCTCAGCCTGGGCTTCCTGCCCATTCCTGGC


TGTCCCAGCCTGATGTGTCCTCCAGGGCCCCCTGACCTGACCCTTGGCCCATCTCTTCTTGACCTTGCACTGTGGGCAGGACAGAGA


GGCCAGGGAGAGTGTCCAAGAGGGACAGGATCGGATGTCAAGGTGACGGGGCGATGATGGTGCAGAGGGCAGCCCTTGGGATGAGCT


CCTGGGAGCTCCTGGATGGGATTCAGGCTCAGCAGGTTGGGGTTGGAGCGGGTGGGGAATCCCTGGCATTTGGCAATTGCCCAGCAC


AGTGCCTGGGCATGGTAAGTGCTCAGTGAATATATGTTGTATGAATGCACAAGTGAATGAATGTTTGGCTATGCGGATTGCAAAGGT


GTCTTTCTGAAATGCCTCAGGGATATCTTTATAAATTATTGCAGCCATAAAATGCTGATATTGGGGGTGCAGTGAGCAGCTCCGGAC


TGAGGATCAGCTGCATTTACCTGCACTGACATCTGTATGGCAAGAGAAGGGGTGTTTGACTACAAGGGAATGCATGCTTCTCTTTGT


GTGAAAACAGAATGAGATTTTTCGTATGCATGATCTCATCTCATCCCCTAACAGCTGTGAGAAAAGTAAGGGTAGTTCTTGTTTGCA


GAGAAGAAACCAGAGGCCCAGAGAGGTTAAAGGACCGATCCAGTGTCACACAGCTAGTTAGTAGCAAAGACATGACTTGAACTCTGG


CCTTTTGGTTTCAAATCCTATGTTATTTAGAAAGAGACAAGGAACATCTTCGTTAGCCCCCCCATGACTAAAAATAGGAAGCTTGCC


TTGTTGTGTTTGAGGAGAAGATGGTGTGAGTGGGTTTTGTGGCTGACCGTTTCACACCCAACATTTCATCACAGAAATGCCTGGGAA


AAGAAAACTCCTAAGAAAAAAAAAAAAAGGAATGAGTGTTGGACATGTCCCTATGACCTGTTTGTCATGGCATGTGTGCTCGGCGCC


TTGGTCATCAGGCTTAACTGAACTTCGGAGAAGGTTCTGTCCAGGAGTCTCATTTTACTGGGGGCTGAGGCTTAGGAGAAGGAAGCA


ACTTGTCCAGGCCAGGCATTCACTATGGAGGAGGCTGAGACTCCTGCGCCCTCGGATGCACACCCTGGGCCTCTGTTCCAGAGCTGT


CTTGGCTAGCAAGTATCAGGCCCTTCTCCCTTCTCAGGCTGGTCAGAGGTCCAGCTGCCCTCTGGAGTCCCCAGAGTCTCCCTTCCC


ACTGTGACAGCATCGGCTGTCTCTCCCGGTCTCAGGTTGGACAGTCCTGGGAGAGAGAGGGTCTGAGTGACTTCATTCTGTCACTTC


ATTCATTAGTGACTGAAACAGGATTCTGTTAGCTGACTTCTGGTAGGAGCCAGGTTGGGAAGCCGCTCTGAGGATGCTGGGAGGGCC


AACAGCTGCAATTATTATTATTATTGTTGTTGTTATTATTATTATTATTATTGAGACAGAGTCTTGCTCTGTCTCCCAGGCTGGAGT


GCAGTGGTGTGATCTCGGTTCACTGCAACTTCTGCCTCCTGGGTTCAAGCCATTCTCCTGCCTCAGCCTCCTGAGAAGCTGAGACTA


CAGGCTTGCACCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGATGGCCAGGCCGGTCTTGAGCTCC


CGACCTCAAGTGATCCACCTGCCTTGGCCTCCCAAAGTGTTGGACTTACAGGCGTGAGCCACCACGCCTGGGCTTGCAATTAAATTA


GGGTGCTGCACCTGGGAGGAGGAGGCTGTGCTAAGATAGGAGCTGAGGATGATGGGTAAGAATGAAAGATCCCAAGAACTGGACAGT


GTGAGATTGACGAATGAGGAAGGCCAGGGCTTGGTGCTGATGTGGAGGGAAAGAAGCCTCAGGTCTCCATGGAGAACAGCGACCAGT


GATGCGGTCTTCCCTTTAGCGGAAGAGGGGCTGGTTTAATTTGCATAGCATTAATTAGCAAGAGTATCTAATTAGGACAACCATTAC


AGAACCACAGTCATAAGCCGATGTTGAATATCAATCAATTTTGGAGCCTCTCCATGAAATTGAAGGAAAAGTTGACCTTATTAGATA


GAAAAGATTTCTAAATCAATTATTTCCCAGATTGAATGCACAAAACATAGTGATGTCAGGCAGGCACATCAGACCTTAATTCAGAAA


TTATGAACTTCAGATACTATCACCTTTTCCCTTTGGGGGTTTCAGCCAGTGACAGAAATCGTGAATGGACCACATATGTGTATAAAC


ACACACACACACAACCATACACATATACTCTTTGTGGGTAACAGCTTGGTTGGGGAAGGAGCCTGCGCATCATTATCTCAGTTAAGC


TAATATTTCAGTTTGGTTCAGTGCCCCTCCAGGTCTCTGTCTGTAAGCATAGCTTTCTCTTTTTTGCGATGACCCAAACAATAAAAT


ACATTTAGAACTTCAAAGTCTCTGGGAAGATATACCATAATCATTACAGTTCTGGCCTGTTTTTGGAAGCTACAAGGCAGGCCAGGA


GAGCAATTTATGTGGCTGGCTCAGAAGCTGGGGAACACACTCCATCACCCTCTGCACAGCCTCAGGGGAGGAAAGGCTGGAACAGCT


CTAAGAAGCCTCGCTGCAGATATTGGAGGGCCAGCAAGGCGTGGCCGCCAGAGCAGGTGGGGTGCTGGGACACAGGCGGGGCAATGG


AACCTGGAGGCAGACAGATCTGGGTGTAAAACCTGGCTTTTGCAAATCCTGGCTTTGCCATGGTGAGAAGTTAGGTAACATGCCCTT


GGACAAGTTACCTAACTTCTGAGAGCTTAAGCTTTCTCCTCTGTAAGAGTGGGTTGACAATGCCATCCTTGCATGGTAGGCCCCTAT


AGATGTGCTTTATTACAGATTATTGTCATCAATGAGAAATCACAGATCTGTGAAGGGCTGGCTCGTGGCCTGGAGCAGAACAGGGAC


CACATGGATGGAGGCAGCTCTTAGGAATTCTATTGACATATTTTCAGTCTTTTTCTACACTAAAAAAGCTTAAAAATGAAATAATTG


GAAATATACTACATATCGTTTTGGGGTCTGAGTTTATCACTTAATATTCTATCATCAACCATTCTCCATGTCTTCAGATATTGTCTG


CAGAAGTGTTTTTTGGTTTTTTTTGTTTTTGTTTTTGTTTTTGTTTTTGTTTTTGTTTTTTTTTAAGATGGAGTCTCGCTCTTCACC


CAGGCTGGAGTGCAGTGGCACTATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCATGCCGTTCTCCTGCCTCAGTCTCCCGAGT


AGCTGGGACTACAGGCGCCTGCCACCACGTCCCGCTAATTTTTTGTGTTTTTAGTAGAGATGAGGTTTCACTGTCTCACCCAGGATG


GTCTCGATCTCCTGACCTCGTGATCTGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACGGCCGTGTGCAGAAGTGTTTTTAGTGGC


TGTGTAGTGTTCCATCACTGCCTGATCTCAAATCTACTTAACCACTTGAAAATTTGTGGGCATTTAGGAATAAATGACTTTAAAACA


TGACTCTCAGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACTTGAGGCCAGGAGAT


CGAGACCATCCTGGCTAACACGGTGAAACCCCATCTCTACTAAAAATACAAAAAAATTAGCCGGGTGTAGTGGCGGGCGCCTGTAGT


CCCAGCTGCTGGGGAGACTGAGGCAGGAGAATGGCATGAACCCGGCAGGCAGAGCTTGCAGTGAGCTGAGATCGTGCCACTGCACTC


CAGTCTGGGAGACAGAGCAAGACTCTGTCTCAAAAAAAAAAAAAAAAAAATGATTCTCATCAAATGGGATATAATTCCTAAGCATTC


CTGTGTGTTAAGGATTGTTACTCTGTGTTGAAAAGTTCTGAGTCACGGGGCACAAGGGTTGACCAGTTGACCGCTGGATTCCCTCTG


TTCTACAAGCCCCTTATTGGTCCTCAGATAGGAGTGAGTGGGGGCAATGCGTGTGGCAGGTACCCTATCCTGGGATGTATGGCAGCC


CGGTGTCACTGCCATCCCCCAAGGAACCATATCAATTTCAAGCTTCACTGATGTTCAGGCAGCAAAGAGAAGATGCTAATTCAACAT


TTTACCAAATAGAAAACATTCCTAGTTCAGCCAGACTTCTTTGACATGTTTTCCAGCTATTAAAAGCGGTTGGTTAATTTTTTTTAT


TGACATGCGATGGAGAATGCAAAGAAATCTGTAAGATATCGAGAGTCCCTGTTGATCCAGCACACAGCTTGGTCATCCCACGGGGCT


GGAGCTGGCCAGGGAGGTTGTACTGGCCAAAACCAAGAAGCAGGTGGGAGTTGCCTGTTCATGTAAAGGTTTTGAGCTTTAGGACAA


AAGGAAGAGGCCCAAAGGAGAGAGCATCTGGCCCCTTTCCCTTCACTGCTTCCTTTAAAATGATGGAAATAGACTTGGATTCTGATG


TCAATTCATTGCTGCCAAAAGAAATAAATAAGGGGCTGAAATGTGCAGCTGATCCCAAATCCTTCCCGGGGAGGTGTGATGCTCCCA


GATGCTTTCAGACCCCTTTGAAAAGAAAGTTATGGTCATTTCTGGATGGAAAACATTGTGAGCTGTCCCCAGTTGATCCCCAGTTGA


TTGATGTAGGGAGGTTTGTTTTACCCTAATACAGTCTGAGTGTTCCTGAATTCACCATTTGCTCTTTTCAGCCCCATCTGGGTCTTG


TGGTTGGGTAGCATTTCAGGCACCAGGAAGTGCTTGTGAAGATCAAAATATTTTTGAGGGCCAGCACTGTGTTCTGTCCTTCTCTGT


GCTTATGTTGGACCAGAACAGCACCAGCCCTCCTTAGGCCCCCATACATGTGTGCTGAGTAAATGATTGCAGGCTGCTCTTATGGAA


CTGTGGAACATGAAGAGGCTAAAAGAAGACTGGCTTATGTGTAGATCATCTTATGCATAGCAAATAATGGAGACCTTTTCCCATAGT


TGGACGACCCCATGCAATGTAGAAAGTCAGAGTTAGTGAATAAGCCAGATCAGAAGCTTCTGGTGTATATCACTGTATATATAGAAT


CTAGCACACTGTTGGATATCTAGCAAGTGCTCAGCAAATGAGAAGTGGTTGAAATTTTTGTGAAAGAGTGAATGAATTAGTTACTTT


ATTAGTTTTCTTTGTATCTCCAGTGGGCCTCAAGAACTGTACCAATTAAATGAATGGGGAGATTAATAGACATCAGGGAGAGCACTT


TCATTCCATCTCAGCACACAGAGTGGGGCCGAGAGCATGGACCTGGGCACTTGGAAGTCCTGGGTTCGAGTCCCAAGCCCTCCTCTC


ATTCTTGTGGTTGCCATATTGGACATACCGCCTCACCCCACAGATCTCAGCTGCTCCTCACATCTGCCTCTGAAAGCTGTCTCTGAC


CCATCCACAGTGGCCTCCCTCCTTTGAGCTCCCCTAGCTCTACTGTAGGTTTCACTCTGGCAATTGATCATACTCTACCTTACCTTG


TTGTCTTAAGATGTCATTTAGGTCTATTTAAATGGATGCTTCCCATGTTTCTAAGTTGTTTCCCATTGGAGAGTGTGCCTGAGGGCT


TGTGGGCAGTGCTCTGTACTGCGAGTCAGAGGCCTTGACTTTGAATTCTGGCACAAGCCACCCACCCTCCTCTGGGCCTCAGCCTGT


AATATCTATAAGGTAAAAGGCCGAGGGCTGTTGTGAGGATGGATGAGAACAAATACGTGAAACCACCTTGTAAACTGTAAGGTGCCT


TCCAGAAATCAGGCATCATTCTTCTAATGACCAGCTCCCTGAGGAAGGGAATGTTTCTTTTGTGGCGTGCACCACTCAGGACCAAGT


GCAGGGCCGCCATACACACAGTCACTGCTTGGAAATGCTTCCTGGATCTCATCTGCTGCCTTTGCTCAGGGCTGTGTTCCCGCCTTC


CTTTGGAACTAGGAGCTATCTCTACTTCCAGCTTCGAAATGCCCAGAGGTGCACCAAGTTCCAACCCAGACACCCTGATTTGTAGAG


GATGCAAAGTAAATGATAAGGGTAGTTAACACTTACTTGGCCAGGCACTGTTCTGGGCACTTTGCATACATTAACTCCTTTATTTTC


ACAACAGCCCTGTGAGGTAGTCCAGAATATTATCTCCATCTGACACAGGAGGCATGCTGGTGCAGAGAGGTGGAGTGGGCGTTCCAA


GGTCAGGTAGCCCTAAATGGCTGTCGCAGGGCTGGGACCCAGCAGTCTGGCCCCGGAGGTCATGCTCTTAACCACACTTCTCGGTTT


CTCTAAGCTGCCCTGGGACTGAAAGGCTGCAGTGGAGGCCACGGGGCTCACCTCCCCCACCTAATCCCTAGCAGGAGGGACCATCAG


GGTACTTCTCCTGCCAGGACCCCTCTCTGCTCCTGTGCTTCCTGGCTTCTCTCTCCAGTAGCTCCTCTGCCGTCCCTGCCTCCCTCC


CCTGCCCTTGGCCTAAGCCAGGAGATGAGAGCAGCTGCCGGGACATTCAAATTCATTCCTGAAAGAATTCTGCCTCCGAAATCCTCT


GGTTTGGGTTTAAGAGAAAACAGAGGCCCAAGCTGGCGTAATATTGATGCCCAAACCATGTAATAGCGGCACAACAAAGAATGACGT


TCATATGAGTTATGAGCATGGAAGCACAAATTCTAAATAACACATCAGCAAACTGAATCTAGCCGTGTATAACAAACATAATACATC


ATGCCCAAGTAGCGTTCATCCCAGGAATGCAAATACGACTTAGCCCGAGAAAACAGAGGCTCAAAGGGGGCAGCTGCTGAGACAGAG


CCGGCCCGGGCACAGCCCAAGGCTTTTGTGGGGCTCAGGCTGACTTTGTGCTACACCTGCTCCTAGGAGGGGCTGGTAACAGTCCCT


CCTGTGTCCCCACCCCTTCTCTTTTACACAGCCGCAGAATAAAGTGAGACGCTCCTTTCCCCGCACTCCCTAATTCTCTCTCTCCAT


TGTTCCTGCAGGACTCCATGTTTTCGTTGGCCCTGAAATGCCTTATCAGTCTGTCCACCATCATCCTTTTGGGCTTGATCATCGCCT


ACCACACACGTGAAGTCCAGGTAGGTGCCCCCACCTCACCCCTTCATGCAGCGGCTGATCCTTTGGCCTTCCTCTGAGCCGAGCCCA


TCCCCACCCCCAAAACCCACTCCCTTAGCAGCTACTTGGGTGATTTTACAAGACGGTGCCCAAGATCGTGGCTCTTCTCTTCTGGTT


TGGACCCAAATGGGAGAGGAAACTGCGAGGCCGCCCTGTGGCTTTCGAATAACTGTTAAGTTGTCTTCAAAGTGGGGATCCCAGAGG


CAAACATAGGGCTTCATGTTGAGCGAGGCTGCCGTATTCGGGACCCTCACTGAGCACCATCGGACCGGGAGAGCCCCTGATGCATTG


CTCTGCCTTTTGTGTCTCTTGTCCTTTCTGAACTTGGGCCACTCAGTTCATCCCTTCAGTGAGGCAGACCTGCCTTGTGTACCCCCA


CATATGCTGCACCAAACTCCACCAAGGAGTCTGCTTTTTGTGAATGGTGTGGTCTTCACCCTTGTGGGTCTAGGCTGGGGGTGTCAT


TTTCTAGACAGAGTAAGAGTCTGCTGTGGCCGAGAAGGCCTCTGTTTCTTGCTGCCCAGGAGTGACTTGGTACCCAGAGAAACATTG


GCTGGGCCTCCAGGGTGCACTTCCAGTTTGGCTGACATAGGGAGGATGGTTCAACCCGGGCCAGGAGGGTCAGACACGAGAGAACAG


ATCTGAAGCATCTTCTGGTGACAATGAGCTTCCCCCAGCCCCCGGCCCTTCAGGCTGACCTGCACTGCTGTGGACCTGAGAAGTTCT


AAACTATCCAGATGTTTTTCCTCATGTGCATGTGAATCTGGAAACCATCCCGGTCCTTTGGCTGGAGGAGCACAGATAGATTCACAT


CTGGGCAGCAGGCGAGAGATTGACGAAGACCAGAGCTCAGAGTCAGAAAAACTGGGGTCAAGTCTCGGCCATGACCTTTTTTCTTGG


TGTGTCTTTGGCCAGCCCTGTGACCTTCCTGGGTCTCGATCTTCTCATCTAGAACATGGGGCCTTTATTCCAGCTCTGCTGAGCTGT


TGTGAGGATGGGATGAGGAGCGCATGGGAGAGTGCTTTGTGAAGCGCTATTTAACAACACCGTTCAAATCCAGTCCCATTTGTTACT


CGGCATTTTCAGGGTGGAGCAGCAGTGCGGACGCAGGTGGGAGTGCCTCCTCCTCTTAGAGAGCCTTGGCTTTTTGTCTGAAGGTCA


GGGGCCACTGTGGCTGGCTGGGACATGGAAGCCTTGGCTCCAGGCCACCTTGGCAGGGCTGCATTCTGTCAATGACTAGAGGATACT


GACCTGGATGCTGGGACTCTTCAGCCTCTAAAGGGTTGCAGATGCTTGGACAGGGGCTGTGCCTGTGCCAGATGCCACCAGGCAGCT


TCCTTCATGGAGTCTGAATTGGACAGAGTGGTGGACTTTAACTCAGACCATTGTCCAGTCAGCCCCAGAAAGGAGCCAGGAGTACAG


GCAGGGAGGACTAGGGCCACGGAATCGAGACAGGACAGAAGTTGACAGTCTGGGCTCCGGGCCTGGTTCCACCCCACCCAAAGCCAG


CCGCGGGATCCAGGCAGTCCCTCAGTGTTCATGTTCTCATCTGTAGGGAGACTGTATTACTATGTGTCACCCTGACCTGTGTGGGGA


GGTGTCACACACAACAAAGAAAAAAGGCAGAACCATAAAACTCAGTTATGACCCAGGCTTGAGGAAGGGGAAGAAGAGGAGCTGTTC


TCAGCCTCAACCCCACACTATGGTGGTGCTAGGCCTGATTACTTCCTCTTTCTGCTCCAGGCATTGGGGTGGGTAGAGCCAGGTGTC


CCTCCCTCTGATGCTCCTGAGGTCCTTGTTCCCAGTCCAGGGCCTGCAGCCCTAGCTCTCAGCCTGTTCTGGTCCAGCTGCAGCTTG


ACTCAGTTCCGGCCTGGTGGCAGGCTCATGTTGCTGACAGCCCAGAACCTGGCTGGGTACCCATTGTCCCATGTCCAGCTCATGGCC


AATCTCTGTTTCAGCCCTAATCATGGGCAGTAGATGATGCTATTGGGGGTCATTCATTTTGGCCTGACACAATTTGGAGAAACAAAG


TGAAATCAGTTGTGTTGAATCCTGACTCTGGGGCTCAGTTTCCCCATCTGAAGTATGGGAACCACATCACCCACTTTGCTGAACTCT


TGCAGGGGTTGGAAACAGTGTAGAGTACAGAGTGGGCTTTCACAGAATGGAAACTTTGGTCCCTTTCCTGTGACCTTTGTCCCACTG


CTTCTAGCTGGGCCTTGCACTTACCAGCTGGGTCCACCAGGTGGTCACTATCACGACTGCCTGGTACTGGCAGGTGGCTGGGCTTCC


TCCTGCTCTGGCCCAGCCCTGCCTGTACCCTGAGCTCCCACCACCCAGCCCCTTATCCTCCCTGCAGCCTCCGTCACTTGAGGAAAG


TCACCAAAACCGGCTTCCTCTGTGCCTCTTACCTTTCCAGTAAAGTTCTTTCTGTGCCCAGCTAGACCTTCTCTTGCCAGAGGGAAA


TGGGAACAGTTTGGGCCCAGAGAGTCAGTGGGAGGGAGGTTCCTACGGAGCGCCCTTGTATATACCGCACTGGGCCATATTGTAGTT


TTCTGTTGGGTGTCTTTCTTCCCTACCTCAGGGACAGTTATCTTTGCATTAATCTTTGCATGTCCAGAGACTTATAGTGTCTGACAG


TATACTCTTCTCGGCAGAGTATAGCACGTTTGTAGCACGTTCTTTGAATGGAAAGCATGCTGAGTTCAAGGTAACTCTTTTCCAAAG


CTGGTCGTACCTTGACTTAGCTTTTTGGTCTCGGGCCTCAGTTTCCTCATCTATTACTTAGCCCCCCAATCTTGTAATTCTCTGATT


TAGATCTGGCTGCTCAGCCAGCTGCGGAACCTGCTTCCTGCGAGTGGAGGAAGGAGTTATCCCAAGTGTGACTGATGAAGTTATGCA


GAGGGGAGTGCTTAGCAAGCACCCTTCCACAGGCAAAGGCCAGCTGCTGCTCACCTGTTGCGAAGCAGGCAGGGCAGGGGGTGGCTG


CCGCATCTCCCCTTTGGGTGATGTCAGGACCTTTGCTAGGAATCTGCTCACAGCTTTCCTCATCCACAGTGGTTCCTGATCACCTAG


CTAAATTTTAGCAGGGACCAGATGATCATGTCCCCGTCTTCCCCAGCCTTGCCCCAGAAGCTCACACCCAGGACCCAGGCCCTGCCC


AGCACACATGTGAGGCTGGGGGAGTACCTTTTAGAACAGTATTCTTACTTGTTCATTTAGATGGCTTGAGTTTTTCAGGAAGAAGAA


TTCTAAAACACTGTTGGGTAACTCTCACCCAAGCTGGGTAATTTATAAGGAACATAAATGTATTTCTCACAGTTCTGGAGATCGGGA


AGTCCAACATTAGGGTGCCAGCAGCTTCAGTTGTCTGGTGAGGGCTGCTCTCTGCTTCCAAGACGGCGCTACGTTGCTGCATCCTCA


GGCAGGGAAGGCAGGAGGCTGAGGGACTGAACACTGCATGGGGCCTCTTTGATACAGGCCTCAATCCCATTCACAAGGGAGGAGCCC


TCATGGCCTCAACATCTCTGAAAGGCCCCATCTCTTGGCACTACCACATTGGCAACATCTGAATTTTGGAGGGGACACGTTTAAACT


GTAGTGTCCACCTAGTGCAGGAACCCCAGGGCCTCTGTGTGTGCTACTGTGACGGAGCTGCTGGCCCCCCTGGGAGAGGCTGCCCTA


CCAATGTCTTTAGAAAGCCCGCCCTTCTGCCGAGAAGAGGCAGCCTCCCTGGAACTTGCCCCCTGGCCTGGTTCTGCTTCTGGAGCA


GGGAAAAGAAGGGGTTGGTTTCCCGCATGGTAGCCTCCATTGTTGGAAGATGGCACCCCACCCCATCTCTCCTCAGTCTCCCTCTCT


GTTGGCGTTTTGGAGCACGGACCTTTCAAAGACTCAGGCACCTCTTTTCCTCAGGCCAGTGTGTCCGGGAGAGAAATGAAAACACAA


GAAGCAATGCATTTTGTTTATTTACCAAAACTCTGACTGAAAACCATGCTCTCCCTTGGAGAGTCCATTTACTTCTGTGGTTTAGCT


CTCACCAACAGCTCTCAGACCGTGCTAATCCCCTCCCCAGGCTGCAGGCTCACGTTTTACATGCCACCGGCAGCCCCTGGCTCCACA


CACAAAACACTGAACTCCTCTTGCTCCCCAGTATCCTCTCCTCCTTTGCCCTTGATGACCCACCAAGTGCAGTCATTGGTTCAGCAT


CTATTTAATAATGTTCTTCTAGGTGCAGAGCCCAGGACAGGAGCCCAGTTCTCTAGATGAGAAACTCAGAATTCACCATTGCTTCTC


CCAGGGGTCATCAGCCTTGAGTGAATCTATGGCTCTAATGAATGGCCCTGGTGCCATCCTGGAAGGCAGGCTAGCAGGCAGAATCAT


AAAACTCAGTTATGACCCAGGCTTGAGGAACGTTCTCTACTGAGAATGTAGACTTCAGAGCAGCCCAGCTTGGCGCAAATCATGCTG


TTTGTCACATTTAGTGTGTAGGTGGCCTTTAGCAAGTTACTTAATCCTTCTTAGTCTATTTCCTTTCTGTAAAATAGGACTAATAAC


CATACTGTGGAGGCCACAGCAACTCCATCTTGGATGCTGATCCTCCATATTGACTTCCGATTAACCCAGTTTCGGGAAAGCCTCTAA


GATTTCTCCTTTATCTACTGTTTACTGTAAGTCCTGCCCTTAGGCAAATTGCTTCTGAAGCACATATACCCCTTTCCTCTGGTATTT


AATCCCTGGGACTAGGGGGTCGTGGTGCAGGATCCACCATCTTGTCTTACTGCTGCCAGAGACTGTGGCTTTTGTTCATAAGTCCCT


ATTAAATGCTTCTTTCTGAGAAACTGGATATGTCAGCCCCTTTCTTCAGCCTTTCAGCTTCCTCAGCCTTTGGGGGTAGGTTTGAAT


ATGCCTACCCACCCGGAACCAGTACCTACCAGAAAGGGTTATTGTACAGATTAAATTAGATAATATATGCAGAACTCCTTAGCTTAA


GTAAGAATGTGTTTGTCTGGCTGACAGAGTGGAAAGGATACCCCAGACAGAGGTCTCAGAGTAAACAAAGGCTCTGAGATGGGGAAC


TGCAGAGCACACTGGGAATGTCTCAAGGACAGGGTCCTGGGTAGAGGGGCAAGTTCACTATGGAGGGTGGGAAGGACCCGTAGGGAC


TTGTTTGCCTTGCTGAAGGGTTTTGGAATGTCCTGTAGGCAGCAGCAGAAACTATGAGAAGGTTTCAAGCTGGGGACAGAGATGATC


AGATTTACATTTTAGACAGCACTCTTCATCTGCAGCATGCAAATATAGGAAAGGCCAATTTCAGAGGCAGGAGGACAGTGGGAAGCA


CGTCATCATGGGCCAGGTGAGGGGTGTTGATGCCCAGAGCTGGGGCAGGAGTGAGGAAGGGAGGATGGGAGGGATCCAGTACCCCTG


GGAGGAAGTGCCTGGCTCAGAGCCCCAGGCATGGAATAAGGGGTGGGGTGCAGACACATTCACATCCGGAGGCGTGGAGCAGAGCCT


GGCATCCTTAATAAAGTTGCAGGGATGGGAGGTGCCGTCCCTACATCCAGGCCAATGCCCGGCACGTAGCAGGTAGTCAGTGAATGT


TTATTGAATTAAACTGAAGAGACTACTGTGACCCAGCATGGGATACAGAGCAGTGGCAGAGTTCATATAATCCAGTCCCAGAATGGG


AGCTTCAGAGATCATTAATTTCAAATTGTGGTTCTTGGCCATATTCAAAGTAAAAGGCATCAATCAGATCAATGGGGTGGAGATCCA


CTCTTGCCTGGGGATATCAATCCCCTCAAGATCTAGCGTTGGTCTCAGATGTTTCCAGTCTTTTTCAAACTCAACAGAAACGTAACG


GTAGTAACAAACTATGGGCCTTCAACCTCATGAATTTGAAATACAAGGGACCAAAAAAAGGGGAGGCTTTTAATTTATTAGGTATAT


AAAAGTGGATATTTTCATTAAATACCAATAGAGTTCTGAGCAGACAGGAAAATTACTTGAAATTACAGGACATAAATTATAGGAAGC


CTCACTTCCTGTGGCATAATTGCTCTGTGGATGGGAGTGTCCTCCTGGGTGCGTGTAATGTGCTGTCACAGGGACATGGGTGTCTGT


AATGCAGGAGGTGTTGCTGGCCCAGGTGCTTTGGGGTCCCACCGCTAAATGAGTTAGTGGTGTCTTCCCCTGAAAGAACAGACAGGA


CAACTCACCTTGCGTCTTGCTCTGTGCCCTCACCCTCCCTTCTCCCTGTAAAAGAAAGCAGGCTCAAGTCACATCCTGAATGTAACC


TGTAAGGTGTCCTGGCACTGAGAGACAAGGTATAATAGCAGAGCACGTACTGACCTCTCTAAATTTTCCAACCCTAGTACAGTCTAT


AAAAATGGTGAGTCCATTCATTCGTTTACTTATTCAACAAACATTTATTGTAGGACTACTTTGTGCTAGGCATTGAGAATCCAGAAA


TAAAGCAGACCTGATTCCTGCCTTTGGAAATTGGTTTGTCCTAGACCTTTATCCACTGTGACCCAGGGTCATAAGTGCCATAATATG


AGGGTCTGTGAAACACCAAGTGGCCACGGAGGAGGGAGTGATGCATTTCTCCCAGAGAGGCTGGGCAGGTTTCACGCGGAGATGATG


CTGTGCCCTGCATTCGCCAGGAGCAGAGACCTTGTATGCTCAGGACAAAGCTGGCCCAGAGCGTTTCAGGAGAGGAAAAAAAAAGAG


AAGGAAGCTGTGCCTGTCCTCCGAAGGGAGGTGGAGGCTGCCCAAACCCCCCAGGTAGGGGCTAGAGTCCCCATCCTTCTTCAGACA


CCTGGTAGAGGTTTCCTAAGGGTGTCTCTGGCTGGTTGGTTGATGAATTAGAAATACCTTCATTGAACCTCCGAGATCTTGACACCC


CCAGACAGACTTCTCAGCCTGGCTAGGTTTGAGCATGTCAGCTCCTTAACTCAGGTGTGATGAGCAGATGGAAGGAGGGAGCTCGGG


CCACTCGTACTGAAGGGGAGGAGACCTTGACAAGGAAATTCCAGATGGGGGCCTCCTCTGCCAGGTTTACATCCCTCTCCTGTCCCA


CTTTCATGAGTGTGCCCCTGGATGATCACAGCACACAAGGGAAATTGAAAATGGGGAATGTGTTCCAGAGAACAGCGACTGGTGATG


GGGATTCACTGGAGCGCTGCTCTTCTTTGGGCCTCGGCCTCCTGCCTGGCCCAGCTGTGCACAGTGGGGCTAGAAAGAAAGGGAGAA


ATAGAGAGAGGAGCTACACCACCAACTGGGCCCGAGAAGTCAGAACACCATGGAATAAATCCTCGTCAGACTACACTTTGAAGACAG


AAAGCTCAGAGCTGATACATTAGCAAGCGCCTCAGAGACGATGGTGTGGCCACGTCTTGTCTAGCGCTTTGTATTTTTTAGAGGGTT


TTCACATCTATGAGGCCTTGGGCCTGGCCGCCTTCACCTTTTTGCCTTTTAGGTTTCAGCATAGATATTTCCTCCTCCAGGAACTCT


CTCTGGCCATCGTCCCCCTTCCCTGACCCCAGGGTGCCCCTTCTAGGAGTGGACCTAGCACCAGCTCTTATAGCAGCGGCTCTTACT


TGTCCCTGCGTGTCTTATGTTGGTTGTGAATACTATTTCTTGCCTGCAACTCCCTTCTCTGACTGTGGGCTCCATGGCAGTGGGGAC


TGTATTGGTTTCACTGTTGGACCCCCAAAGGCATGAGAGTGCCTAGCACATAGTAGGTGCTATTCAATGAGTGTAGGCTGAATAAAT


GAATGAATGAATGACAAAACTGGGGTAGGCATGGCAGATTTACTCCCTCCTCATTCTAAGGAGAAAGTAGAGCCTCTAACAGGCTGA


GAGCCTGACCTGAAGCCCACAGACCTGGCATCTGGCCCGTGCTTTCTGCATCCTAAGGGGCTGCGGGTCCCAGCAGGTTGCCCAGTG


AGCTGGCCATGCCCACCATGGCCCTCCCTGCCACTCTCTGGGAGGCCCACCTCGATCCCAGCACCTTTTCACTTGGATCGGCCGCTG


GCCATGGATTGCCATGGTTACTACACCAGCCCTGGCAGTCTCTGTGTGACATTTTGGTTTTATTTGCTAAACATTTAAACACTTGGG


CTTAACCCTTTCTGCCTCAGAGGGGGCTTTCCTGCCCCTGCTCCCTGTCCCTCAGGTGTGAGGGCCCCCGGCTGCTCTCCCTGGCCC


TGGCTGGCGTCTCCGATGGGGTGGGTGTGCTCGTGGTGGCAGCAAGGCTTGTTTCTCGGCTGCCTGTATTGACTTTCTGTTTTGTCT


CTGGGGAATGTCATCCTGGATCATGCTCTCACTGGGTGGTGCTGTGTCCATTAACAGGTGTGAAAAGCCCTGCTCCGGGCATGTTAA


GGCTTGACCTCCCCGTCAGCTGGGGTTCTGTTGACTTCCAGGCAAACGCCTCTTGCCAAGTCCTCCAGGAGCTTCCTTAGCTCCAGG


AGTTCAGGACGGGGTGGGGAGGGGTCATCTGCCCTTGAACCCTGGCAGGAGGACAGAGGGGAGACTGGTTTCGGGAAGAGTCCGTGT


TTGTGAATGGGAAGGCGGTGCGTCGCCTGGCCTCCCACGCCTCCTCCCCTGCGGGCTTAAGATGAAGCCTCCCAGGAAGAGGAGGCG


GCCCGGGAGGCTGAATCCACCCAGCTATGTGTTACCTTGGAAACCACACACTTGTCCTCGCCCTAGGCCATGTGAAGTGAGGGGGCC


GTGGACACGCTTCTCAGGAAGCTTCCAGTGTAACTCAGGATACAAAAAATCACAGTCCCAGCATGGGCAGCTGAGAGAATGAAAATG


TTCAAAAAAAAAAAAAAAAAAAAAAGCAGCCTAACAACTGCCCTGCCCAAGGGGCTCCCACCCCAGCAACCCTCTGCCCATTCTACA


TGGGACGAGAGGCCAGGGCCAGTTTGTCTGGGATGCTGATCACTTGTGAGCTTGGACAAGCTACTTGTTCTAGCTCAATCTCAGTTG


TGTTGTCTGTAAAGTGGGCAGATTAGGCCAGAGGATCTCTGAGAACTCTGATTGTAGCCAGAATTCCATGTCTGAGGGGCACTGCCT


GACAAGGAGAGGAAAATGTCGGGAGAGTGGCTGTGAGCGGTTTTTGGTAACAATGACTGACCTGGTTTGTGTTCAGGAGGCCCTTTG


TGGGACTGTCCGAACAACTTCTGTCCCTTCTCTTAATAGCCTTGCCTCTGCCCAGTCACAGAGCTGGCTGTCCCCTAAACACAGCCT


CAAACTTGACATAGAAAACAATAATAAAGACAGCTCTTTGGCTCCAACATCTTAAAGTTTAAAGGTGACTCCTCTTGAGTCTCTTAC


ACACAGGAGCTGGTCAGACAGCTTAAAGTTTTCAGGATAATAGAGTAAGTGGCCAAGTCCCCTGCCTTAACAATCCATTCCAAACTC


CTTCCATGAACGCGCACTCCCACTTCTCCAAAGTCATGGGGAACAAGTGCTCAGCTTAATAGAATATTCTGTTTCTCCATCATTCTC


AGCAAACTATCGCAAGGACAAAAAACCAAACACCGCATGTTCTCACTCACAGGTGGGATTGAACAATGAGAACACATGGACACAGGA


AGGGGAACATCACACACCGGGGCCTGTTGTGGGGTGGGGGGATGGGGGAGGGATAGCGTTAGGAGATATACCTAATGTAAATGACGA


GTTAATGGGTGCAGCACACCAACATGGCACATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAAAACTTAAAGT


ATAAAAAAAAAGAAAAAAAAAGAATATTCTGTTTCTCTGAGAGTGCCAAGGTGTGTCATCCCTGACTTTTTCAAAGTTAATCCGTTC


TATTTGGTTTTGTTGTTACCATTTTTCAATGATGATCATTTCCCCCGTGGCAGCGGTTCTCAATCAGGGGTCTGCCTCAGATCCCCC


GTGTCATATCTGGGTCCTGCATAGGCAGGTGAACCCCACTGCCTGGGAATGTGTGTTTTGACAGCACCGCAGGGGGGCCAGTGCACA


CTCTTATTAAGAAACATGGCACTCAATTAAGCTCAGGGAGGCCAGCGTCTTCCCAATCATCCCTGCAGCCACCCCTGCTGTGCCTAA


CGAAGAGCACTGTGCATAGTAGGACTCAGTGACTCCTGGGGTAAGGATCATTGACTCTCTGAGAATTTGTAAAGTTGGAAGGCACTG


TTGAATCTTTAGTGTTTGGAGGCTTCTATACAAGTGTTGTTGCATTGTGCTATCAAGAAAATTCTGATAATTCTAGTTTCCTGTTGA


GTACAAATCTAGTAAAATGACATTTTCCTGTTTTTAAGAGAAAAAATGGCAAAATCACCACTGCTCAAATTCTCCAAAACCCAACAA


TTGGACGAGGAAAAGAGATGAACTGCCCCGATTTACCTTTGAATTAAAGAATTCGATGCAATTCAATTGAGCAGTTTTGTTTCCTCC


AAAGGCATCTCCCATACAAACCTGTCCTGTTAGCATGATGGTGGGAGAGACACTGAGCCTGCGGTCCGTAGACCTGGGTCCAAGTTG


AGACTTGTTCATTTAAAACACTTTTTAAACTTGTGGTAAAATATACATAACCTATAATTTAGCATTTTAACCATTTTTAAGTATATG


GTTCAGTGACGTTAATTGTCTAATTATATTCTTATATATATATTTGTATCCTTATTATTGTATATTTGTCACCACCATCCATCTCCA


GAACTGACTTTTGTCATTTTCTGTGTGGCCTTGTGTGCCTCCACCAAGGCTTGTGGTGAGCTCTCTTCGCACATCATCTCCACAAGC


ATCTCCCACTTTGTCAGCCCCTAAACTTACCTTTACCCTGTCCCATCGCCCTAACGTCACGGGCCGGGGTTCTGATTCCAAGTTTCG


ATTGGGGAAGTGGTTGGTAATCCCACAGGTGGTAATAGTGTCGCCTCCATCTGTTGATCTCTTGTGTGCTGGAGACTGTGCCTTTAC


TTTATCATCTCAGTGATTCTTGGCGACAGTCCCGTAGTTAGGCTCTGTATTCATACCCCCTTTATAGATAAAGCAACTGAAGCAGAG


AAGGTAAGAGATGTGTCCACAGTCATGTGGCTGGTGAGGGCAGAGGGTTTTGAGGTCAACTGTTTGAGTTGACCATCTCCAAAGCTA


GCCAGGTTGCCCTGCCTGGGGGAGAGAGGCCCGTCCTCAAATTAACTCTTCTACCCCTGGTTCCTACAATGGCTAGAAGCAGCCTAG


AAGGTGGGCTGAGTCATGGGGACTTCCCTCCAACAAGGGTGAATATTAGGAAGCCTAGGGCTGAACAGTAACCCAGTGTTGGTCCAA


CCTTGCAGCAGCTCTGGAGGCCCTCATCCCAGCCACACCCCCACCTTGGCTGTGCCTTGTGGTGGCTCCTCTGCCTATTAAAATCCC


TTCCTTCTCCTGGTTTCCCTATTGTCCTCCCCTTGGGTCCAAGGCTTGCCTCAAGGATGAGGCCCAGCACCCTTGGGGAGGTAGAAG


GGCAGCCATCTCAGGGTAACCTGCCCAGCCATCAGAACTGGGACCCGCTTCAGTTTCTCTGCCTTGCCTTCTGATCCCAAGGAAGGC


TAGGGTCTTCCTTGAAGCCTCACTGAGCCCCATACTGGGTCTTGTTCTTTCTTGCCTCCCTGCCTTCTGAGGGGCTGACTTCTACTT


CTGCTCGCCTGGAGTCACAGTGTCCCTGATAGTCCCCAGGCCCTCAGGATCAGACCTGCCTCTAACCCCAAGCCATCATCTGCCTGG


GCTGAGTCTGGTCTTTCCCTTAGACACTGTGCCTTGGGCTGCCAGTGGCCTGGGTGAGTCAGGCTTCAGCAGCTCTTCCTGTTTCCC


CGCCCATATTCTCCCCTCCTTCTGCCCGTTCCTATGGTAAGGTGCCAGCAGCCTTCCACCCAAACTCCCCTAAGCTGGACCCAGGAC


TTCCCTAGATTAAATGCCCCCACTTCCCTGCCATAATCATGTCAATAATCCTGTTTCCACCCTGATCTTGCTACTCTGAACAGGATC


TGCTTGGTCCACAGCAGCCCAGGGATCTGGTGACACACTGACCCTTACACACCACTGGGATCAGGTCAGTACAGAAGGCACCGACCT


GCTTTCTCACTTTGTTACTGCAGCCAAAGACAGCCAGTGACTTTTAGCTTTCATGGTAGCCTGTTAGTTTATATTGAATTGAATATT


TACTAAAACCCCTCTGTCTTCTCATGAGCTGCTAAGCAGCTCCCCACCCTCTGCCCCCTCAATCTCCCATCCTTCCTAATACCGTTG


GCTTTTTAGGTGAGAACTGTACCTTTCATTTTCTTCTGTTACGTTTCCCTGCAGCTGTTTCAGCCCTTCATTCTAGTCTGTCCAGGC


CTTTTAGCATCTCACTCAGCAACATGTATTTGGGGGCCTCCCAGCTTCCTGCCCTCCCACATGTGATGAGCCTGAGTATAATAGCTT


CATCTAAACCATTGATACAAATGTCGAACCAGAAGTCAAATCTGGGAGGTAAACTTTCTTTGGTTGGACTAAAGACAGGAGAAGTAA


AGAAGAAACTTCAAGGATTTGCAAATCTTTTTCATCTTAAAAGTTTTGTGGCCTCCTGTGAGGTTGTAGTTTTATGTGCCCTCCCAC


CCCAGCCCCCAAATAAGCCTGCTCTGCATTCATAGAACACGTGTTTATTGAGCCATGCTCTGTGAGGGGCACGGTGCCTGGTATGGG


ACAGAGCTGTGAACTACAGACTGGACCCGGTCTCGTGTTACTCACAGTCTGTGAAATGAAAGCGTGGCTGCTGGTGCTGGGGCTTGG


CTGCTGGGGCTGAGTGTTGAGTCTGTGAAATGGACGGGTGAAGCCGTACACCTGGTCACTCGGTGAGATCACGTTGTGTCACAGGAG


AGTGCTGAGGCATGGCCACCGTGGCTGGACGTTCTCAGAGACACTGCTCAGCCACAGCAGCTGGGCCTGGCTATGACCACTGACCTG


TGACTACATCAGGCACAGCCACAAACCAGAGATCAGTAACCAGACACGGCGGAGCCATCCAGTGGGCGCAGAGCAGCCACCGCCTCT


GAACTCAGAGCCACGAGGCGGCTCTGCGGGAGCCGCCCGACACCTGCCTGCTGTGTGATCGCCAGCAGACCCTGCCCCTCACTGCCC


TCAGATCCCTCACTTGTGCATCTGGGGAGGAAGCTAAGCGCTCTCCAAGGTCCCTATCAGCTCTTTATGGTGCTTCTTGCTAGAATG


TGCTAGAAACCATATCGATTTGAGAGCAAAGAGAAATTGCCACCAGTGGGTGTGTATGTGTGGAATGGGAGGCGGGGGAGTGGGCAG


GGCGATATTTGTCTTCCTGCTGCTGTTAGAAATAGCAACTATTCTCTCCCCTGAGGACTGGACAAAAGGTGATTAATTCATTCAGCA


CAGAGCTATTGAAGGGCTGTTCTGAGCCAGGCACCGTGGGGACAGCAAGGTCCCTGCCCTAAACAGGCTTGTGATCTAATGGAGAGA


TAAGCACGCAGACACACACGCCTTGGCTGCTGGTGCTGAGGACAAGGGTGTGGAGGGCACGGCGCACAGTTCCACCTAGATGGGAAT


GAGGACGCTGCTGTGCAGGGCATCTGAGATGGTCATGGGGTCAGTTCTAGCAGGTGCAGGTGGGTCGAGGGTCCTCTAGGGGAAGGG


ACCAGCTCCAGCAGCTCTGAAGAATGCAGAAGCTCAGGGCTCTGCGGAATGGGAGGCATGCAGCTGATCGTAAAGGGAATGTTGAAA


GGTGAGAATAGAAAGAAGGGCTGGAGCCAGATCCTGGTGAGCAGCAGCTGGAGCGATGAGGCACCCAGGTCTAAAATGGTAGTAGCC


CCATTCTATCTATGAGAAGGGGTTGGGGGATGGCGATCTGATGGCGGGAGAGGGAAGCCAGGGAATTTGTCTTCAGGTTGCACCTGC


AAAGCATTTTATGTAAGATGGAGAGAATGTCAATAGTCTGTATCAAAGACTGAGAGGTAAGAATGGGGATGGGAGACGGGTGTAGAT


TATGGTACAGGTTGAACCCCCCTCAATCACTGGGACCTGCTCTGACCTTAGAGTACAGGGTTGGGCTAGAGGAATGGTGGATGAATC


TCCCTCCTTGGGAGATTGTTAGGATTAAAGATGAGAGCCACCTGGTACACTCTTGTTTAAGAGTCAGAGGAATGGAAAAACACCCCT


CCCACCCCAAAACGCTGAGGTTCTGATCTCACTGACTGAACACCACCCAACCAGGAGCCAGGGCTTGAGGGCAGCCCGAGTTTGTCT


TGCTCTGTCGGATCTTTTTGGATGTTTAGCAGGAGCGACACTGATCAGACTTCACAAGAACCTTAGGATTTTACAATTTTGCTCTTC


CCTTATTGTTCACAAATCAAGCCTATGCCTAAAAATACACTCTTCTCCAGCAGCCTCGGGGACTTAGCTTCTCCCCCAGGCAGGGAG


TTTACATCCTTCCTTTGCCTGCAGAATTCAACCTTGCAGGTTTGGTGGGGTGGCTGGAAACCGCCACCATCCCAGAGCAGGCTTCTA


TCCCCAGGGCCTGGCTGTCACCCGCAGCAGCAGTGACATCACCCAAAGCCGACTTTGTGCGGGGGGCTTCTGAGTGTTAAGTGGGCT


CAAAAGGTTGAAGTGCGGGGGCAGGTAGGAGGAGCTGCGTGGCTTGGGAAGGAGCAGCTGGCGCTGTAGAGGGAATGACTTGCCCCA


GCTGCTGTTGGGTTACGGGCTCGAGTTGTCCACAGCCACCAGGGGACATTTTTTCCTCTTCTCAGTTCCTCTTTGACCCTGCGCTCA


GCTTCACCAAAACCACCTTGTCTCACCTTCTCTGTGTGTCCTCGGCCTCTCCTTTCCTGCTTGCCTCAGTCTTTCCCATCTTTCAAA


TCTAAACATGTGGTGTCTGTTGCTGCGGGTTGACTGCATGTGTATGTGTGGTTTTCAAGCTGAATTGACAGGGCTGAGTTTTACAGC


CAATACTGCCTGGCTCTGGAAGAAGAGAAAGAGGAGGACAATGAGGGACAGGATCTCTTGTAGCAGAGAACATTCTGATCCAAATGT


CCTTTCAGGATAAATTTAGTTCCCGGGGCTGGGACCACATTCTAATTTGGTGGGAGTCCTTGGGCACCCTGGTGGGGAATGGCTGCT


TCCTTCCTCACCTCCCTGGTCGATTTCAGGGACCGCAGGAAACCCAAGCCTTATGAACATTATACAGAACTGCAATTACAACAATCC


TGAGCTGACATAAGATTTATTCATTGGGCACCAAATTTCCTTTAGGCCCCTTTCTAGTTTGTAGTTTTTGAAGCTGCTACATTTTTT


ATGGCTGGCACATCTCAAGGAGGAAATGCAGATTAATAGTCTGTACTGGCTGTGTTCTCATGCTCTCAGGATTGAATCAATAATGAC


TGCAGTATTAATTAGGCCTTTATGAAAAGAAAATGAAATATGGTATGACATGGAAGATTCTAGATTTAGAATCAAGAGTTCTAATCT


CAGCTCTGCTGCCGTCTAATGGGTGACCTCGGGCAAATCACTGAATTTCCCTGAGTCTGTTTCCTCCTCTGTATAAACAGGTCATAA


TGCTGGCCACATGCTGATGTTGTGAGCATCAGCTGAGAGAGCTGGGTTAAAGGGCCCACCAGGGCCTGGCACAAACAAGAGACTTCG


GTGACTTTAATTTTGGACTCTCCTTGCTAAGGAGATCACCACTGCAAATCCAGCCCTTTGCTGGTGCACAGTGGTGCAGCTCTTGCC


TGTTCTTGGCAGCAGGTGGGGTACCCAACACCTTGAGATGAACTCTCCAAAGTCCTTGCTGACAATGTCCACGGTCCCTTCTTAGCT


GGTGACCAGGAACACTCCCTAGGGGCCTCCCTTCTCAACCTTCCACTTCTCCTACCCATACCCCACAACGGCCCCATTTCCTGTTGT


TTCTCATGAATAGAGTCTGGAAGTAGAAACACTAGTTCGTGCAGTGTTCACGGACATCACGGGGCTCTAGGAAGCCTCACATCACAT


CACTCTGACACTGACTCTCCTGCTTCTCTTTTCCATATTTAAGGATCCCTGTCATTATGTTGTGCCCATCTAGATAATCCAGGATAA


TCTCCCTATTTTAAAGTCAACTGATTAGCGGCCTTAATTCTATCTGCATCCTTAATTCCTGCTTATAACATAGTCACAGGTTCTGGT


GATTTGGACACAGACATTTTGGGGGGCCATTATTCTGCCTACCACAATCCTCTATTTGTAGATGAGGAAACTGAGGCTAGGGTATTA


GATCACATACCCAAAGTCACACAGCCGGTAAGTGGCAAGGTTGGAATTTGAACTGGAGCTGCACAATCTGAAGTCTACTACTACCCT


AAAGGGCCCCCTAGAAACCCAGAGAAAGCTCATTCCCACAGAATGGCCCCAAACAGCCGACCACAGCGGGAGAAGTAGAGATCAAAA


GAGCCCACCCATTGGAATCCCCACACACCGTTTTAGTTCATAATGCAGAGAAGAGACTGGTGAATAATACTGCATAAACTCTGAACC


AGTGCTTCTCACATTTGGATTGAGAAAAAGTAGTTTGTAATTGCCCTGGGAGCTTTAAAATAATACTGGTGCCTGAGTCCCACCCCT


AGGGATTCTGATTTAATTGCTCAATTGCTCAATTGCTCAGGGGAGGCATTGAATAGAGGCGATTTTTCCAAGCTCCCCAGGTGATTT


GAAAGTGCATCAGAATGTGAGAATCATTGCCCTGAACTAACCCATGGCCACAGCCATTCCCCCTACCTGACAATTGTGTCCATAGTC


TGATTAGACCATGCCCAGAACACACCCCTCCCACCTTTTGGGCCTTTTCCCTGAACGCCCAGGTCCCCCTGTTTCCTCTTCACCCCC


TCACTCGAACCCTGACTGTGTGCCGAGCAGCATTAGATGTGTAGAGAGGACCCTCCCATGGGAAATGGGGCATATTCTCTCCTCTGG


CATCTCTCACGCCCCTCTTGCATGGCTGTCTGCAGAATAGAATTGTTTTAATGTCCTCTTTGTATATGCTATATTTCTATAGAGTCT


TTCCTTGAAAATGTAATTCACTATGTTTTCGGTGTCTGCATCAGTTCAGCTTGAAAGGCAGTGTGTGCAGAGGGTTGGAGGTCTGAC


TCTGGAGCCAGACTGCCTGGGTGCAAAGCCGAACCCTGCCAGTTCCTGACTGAGCTTGGGGTGAACGATTCTAGCTTTCTGTGCCTC


AGTTTCCTCATCTATAAAATAGGGATCAGAATAGCCGTTACCTAGGGTTGGTGTGAGAACTAATGCTTTCATATATGTAAAAGGGAT


TAGGACTATGTATTTGCTCATGTTACCAGTATTGCTACTACTCTTGTCTTCACCGAGATCTGTGGGATTCAGTTAATTTCAGCAGAT


ACCGATTCCCTACTCAGTGCCAGGATGGGAAAGAATAAGATGTGTTCTCTGCCTTCAAATAGTTCATGGTCTTGGGAGGGAGAGGGC


TGGTAAGGAGAAGGGAAGGAGTCAAATAGGTGAACAGCTAATTAATGATATAATACAGTGTTGACTTGGAACCACGTTGCTGTGGAA


TAATAAAGATGGGGACATCATGATGTGGGGATTCACCATGGTCGTGAAGGCATATCATGAATTCTAAGCACTAATAAAAAACTCTTA


GTGCGTTTTGTCCTGCCATCCATCCGCATTTGCGAAGCTGTGGGCTGTAACACCCTGTTAAGCCCCTTAGACTCATTTCATGAGTTG


TGAATTCGAGCCAATTGTGTTAGTGTTTGTGAGTGAACGCATTAATCTGAAAGGTGTCAGTGGCATCCCAGTTCCTGCTGCAAATGC


CCCTCACAGGGAGAGGAACGGGGTGGCTTTCTCCAAGAAAACAGCCAGTCTCTTCAAATCCTAGCCCTACCCTCCTTTCAAGGTGCA


TCCCAGAGAGCGGCTGGAGTCCACTGCAGAGGGTGGTAAAGGAGGACGTGTCATGCCAACAAGGGAGCAATGACAGCAATCAAAAGG


GACATCCAAGGAAAATGCAGAGTTGCACGGGGAGACGGGGTCTTAAAAGCCCACACAGGCAGGGATTGGAAAATGCTCCTCTGGGAA


TGCTCATGTGGTAAGGTGGCCATGGGTGAGTGGGAAAGGAGGGAGGGGTGAATCCTTGGTGTGTGAGGCTCTGTAGAGAGAATGGTT


GCTGCCTGGGCAGATGCCTCCTTCCTGTCCCCTCCAGCCAAATGGTCACACATCTCTCGCTCAGATTAACAGCTTGCTGGCCGGTGT


GGCGCGCAACTGTAGGAATCTCCGTCAGCTGTGGGAACAGCTGTACACTGCCCAGGGCCACATCACACCCTGGCATGTTTCCCATTC


CCTCTTGGTCAAACACACTTAAAAACAGGACTCAACGCTCCTTGGTTTCTAACTGTAAAATATGCCACGTGAAGGATGCAAACTCAT


GTCTGCCTGGGGACTACAGTGGGGCAGGCAAATGTTTGATGGGCTTGTGAGTTTTTGTGTTTTGAAGAAAAACAACTGTCTCAAGGC


AGACAGATGTTGATGAACGTGTTTATTTATAAAGGGCTTACTGAGCTAATAATGACACCAGATCATCCCCAAATGACAGGTGTCACT


GCTGACCTATAGCTCAGAGTGTCACTGCCTCTGTTGGAGCAACCTGCTCCATACTGCTGGCCTTTTTCATCTGCAGCCCAGTGTTGC


TTGTGGCAAAATGTTTACAGTAGCCTGGGGCTTGCGTGAAAGCCTTGCTAACCCATCCCTGTGCCCTGCTAGTGGTCAGAAATGTCT


GTTTTTGTTTCTAGGCTTCCAGAGTCACTAGGACTCTGGGCAGGGAAGGAGGGCCCTCAGGCTCATTGGTGTCTAGGGCCTGGGGGC


ATTTTTGAGCCACTTCACAAAGCCTGGCCACAGTCTGAAGTCCAGTACATACAGCTGCAGCCCAGGTGACTCCATGGTGAATTGCTC


CATCCCTAACATAAGGCACTTGGCACAGCCTCAGTGAGCTATGAGAGAGGCCAGAGTGGGAAGGTGTCATGCACGGCGTGAAAAGGG


CCCTCACAAAGACAGAGAGCCTCTCCCCTCCAACCAGGCAGAACAACTAAGTAGAAAGGCTGGTGCAGCTGGAGAATATGGCCACGA


AAGGAGCCTAACAGTGACAGCCAGAGGAAACCCAGGCCGAAGCCACTGGGCCTGTGTGGGTCTGCCTCTTGGATGGGGCTCCATGCA


CACCCATGTTAGTAGGTGGAGCTGTGTGGGAACATTCAGGTCCCTGGGGTTAAGTCTCATGCCTAGCCCTGGCTGGAGGGTTTTGAT


GAATGGATCTTTTTTTTTTCTTTAATAGTGTAGAAATTGTATTTTGCCTCATATTCTTGGGTTATCCATATTAGTCTGCAGCTGTTG


GTCTTCCTAAACCATGACTGAGTAGGTCATCCTCTGTTCACCACTCGTGATTTCTTACCATCTGGTGATTTCTGGATAATGCTGAGC


CCCTGAGCTTGGACATCAGGCTCTACAGCAGGGCTGGGCTCCATACTTCCCGGGCCCTGCCCCTGGCCAGCTGCCCTGAGGTCACTG


AACACCTGGGGTGAGAATAGATCTTACCCACCCCTGCTCCCTGTGTTTTTTCAAACTCCCCTCCTTCCTGGCTCTGGAGTGAGCTCC


TGGGTGCGGGGTAGTGGCTTGAGCTCCATGCAGGTTTGGTGCCTTGCTCATACTGAGAAGCTCAGTAAGCCCACATCAACCATTTGT


CTTTCTCTAGCCAAGAGTCAAATAGATCCACGTTTAAATCCCAGCTCTGCCTTTTATTAGCTGTTGGACTAGTTGTTTAAACCTCTC


TGCCTCACTTTCTTCATCTAATATCAGTACCTTCCTAAAGGGGTTGCTGTGCCCATTACATGAAATAATGCTCAGAAAGCAGTGGTA


CAGGGTAGGAATTCAGTATGGTAGCTGCTATTGTTTTTGTTACTATTATTATTTCATCTCACCCCTACTGCCAGTGCCCCGCATGCA


GTAAGTGCTAATAATTGTCCAATCAAGAAACAAGTGAACAAAGGCCATGTTCTTATTCCCTTGCTCTTGTGGGTTGGCCCCTTCCTC


TTCTGCTGCCTGCATGCCCACTCCCATCAGACTGCTGAGAGCGTTCCTGGCGCGCCCCGACTTGGTGCTGACATCAGCAAACAGAGC


CCCGGAGGCCGAGTCTTTCACTCCGGGGTTGTGCATCCTCCGGGGGTGTCAGCTCTTCAAGCTCTTCCAGGTCCTGCAGCTGTTGGC


TAGAGATGCCAGCTATGGAAACAGCTGTGCCTCCACCATCTTGCCTCTTCCTCCCCCTGGATTCCTGCTATCCCTTTGGCAGGCAAG


CGCACTTAAAAATAAGTGGCAAAAGTTGCACTTGTTTGAAGTGTAAGATATGTCACTCTCAGAAAGAGATTTTGTTCTTACTGAATA


AAGGATAAGAAATAGATTCCTAGTTAAAGAACTTTTTTGGCTAACTCTTCTTTCAGGGGGTGGGAGCGAGCATCCTTTGTCCTTTTG


GCGTAGGCTCTTGGGGAAGAATGGATGTTCTTGCTTCAGAGCCGCCAGCACAGGCTCTCTGGGCTCTGGCTTTCTCATTGATCTATT


TCCCTCTAGTGAATGGGTTTTACAGAAGCTGCAGAGAGATTTTCCCCTAATGATTGTGGATAGAAAAGAATAAAAAGTGACTCCGGG


GGTATCTTGGGACCTTAACTGTCATTGCACGCTGATGCTTCATTTCAGAATGCAAACGGCCTTCTTCTACTTTGCCGGGATAAATGG


TTCCCTTTAGCTGGGGACAGTGAGAAAAGAAGCAGGGCTTTCCAGGTAAAATTGAACGGCCTCCTGTGTTGGGGGTGAGGCTCTCCC


CCCCACCTCCTTTCCTCATCTCCCCCAGAATCCTAAAGAAAGGAGGACGGAGGCTGGAGTCCACTGGCCAGCTTGGTGTATAGAATC


TTTTTCTTTCTCTTTTTGAGCGGGGGATAAGGTCTGGTTGGAGGGAAGTGGCACCATCTTGGCTCACTGCAACCTCCACCTCCCAGG


CTCAAGCCATCTTCCGACTTCAGCTTCCCAAGCAGCTGGGACTACAGGCGCGCACAATCATGCCCGGCTAATCTTTGTTCTTTGTAT


TTTTTGTAGAGATGGGGTTTTGCTATGTTGCCCAGCCTGGTCTCAAACTCGTGAGCTCAAGCCATCTGCCTGACTTGGCCTCCCAAA


GTGCTGGGATTACAGGCGTGAGGTACCATACCTGGTGATGGATACAGTCCTAATCTGTTTCCTCCTAACAGGCATCTCCCGGTGAAG


CCTGGAGTCTAGGGAAGGAACTCCTGCTTAATGGGCCCCCAGGAAGTCACTTTCTCAGGCTGGCTGGCATCAGAACTGGTGCCCAGG


TAGGAGGTGCCAGTGTCAGTCTTCTCAGGGTGGGGTGGTGTCTGCTTTTCCTGTGGGTCTAGCATCCTCACCAGGTTATAACAAGGC


CAGCTCGGAGCTCTGTACTGGGATCTCTTAACAATCACCGGCCCTGAGCACCCATCTCCTGGGTGAGGGTTTGGGCCAGAAAGATCC


TCTGAGCCAATTCTGGACTCCTTATCTGTGTCCTGTGGTAGAGCAACAGCTCTGTGAGGACAGAGCAAAGCTAGGGGGCCACCGCCG


TGTACCAATATCAGCACAGGAGCTTGGCCCTGGTGGGAAAGCAATGGAAATCCATCTGCGATAGAATGGATGGGTGAAGGAAGAAAC


TTACACCTTCTCAAGCAGGGGCAGGTGGCCCTCATGATTCCAGACTGTGGCTGTGATCTGGGACAAGCTCTCCCCTTTATTTCCAAG


TGAGCTGCTTATATGTCCCATTCTGTAAGAACACAGCCAATGAATCATCACAACAGCACAATGACAATGATGACTTTGGGATCCAAA


ATAAGAAAATCAAACTCCCTTACATTCGTTCAGGAATCTACAGTTCAACGAGGCTGTTTCCCATGCATACGTCACACCCTTCGCCTG


CATGTGAGTGGATGAATGTGGCCTCCGTTTACAGGTGAGGCAGCTGAGGTGCTGCCAGGTCAAGGGACCTGCCCAGGACCATGCAGG


CAGCAAAAGGTGGGGTGGCTGCCTCCCAACGTGGGATGCAGAGCTGCAGTTGCCCCAGCACAAAGTCAGTTTCATGCTCAGCTACAG


AACTAATCTCAGTGACCTTTCCTGGGTCCCATGCTCTGCTGCCAGATCTCTTGTGGGATGAGGCCACCATGCTGACCAAGAAGCTCC


AGACCACGATCAGCTGGCTGTCCGCTGTAGGGGCACAGGTCTCCCCACCCCAGGGCACTTGCGGATTCAGGAAGGAGGCAGTGGAGG


CTCTCCTTGCTTTCAGTAGGAGCTAAGCCTTTTCAACTGCACTCTAGGGCATTTCCAGCAAATTCCTACATGACCCTATGCAGGGGA


GGGGACACAACCCTGGTGGCTTCACTTTATGGGTTGAAAGTCTCTGTGGGCTCCAAAAGCGGGTCAGCCTGCCCTCGTTTTCTGGAG


ACTCTGGCTACGCTCTTTGGACAGTTCACAGGGATAATCTCTAGAGGTGCCCTGGCTAGAACACGGAGATGCCTGGCACTGCTGTGC


ATTCATCCAATGAGTGACAGTGATCTTGAGCCCTTGACCTAATCCGACAGTGTGACCTAATCCCACAGTATGACCCAATCCATTTGG


CATTAATGCTGGCTGAGACTGGAGACCACTGACCTCTTTTCCTTTCAGTTTGATCATATAATAAGAACTGTGTTAGTATAAATCATT


ATTTAAAGTGTGCTTTAGGCCAGGCATGGTGGCACATGCCTGTAATCCCAGCACTTTGGGAGACTGAGGCAGGCAGATCACTTGAAG


TCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTTGTGCATAC


CTATAAACCCAGCTACTTGGGAGGCTGAGTCAGGAGAATGGCTTGAACCCAAGAGGCAGAGGTTGCAGTGAGCCAAGATTGTGCCAC


TGCACTCCAGCCTGGGTGACAGAGTGGACTCTGTCTCAAAAAAAAAAAAAAAATGCAATAAGTGTCAGTGTTGTGTAATTGACTGTT


AGTTCATAGCAATGGTCTCACCAGTCTGCCCACAGTATAGTGAGGTGGTAGGATGGAAGGCCTGGAACTAGAGACTAGGATTTGAAT


TTTGGCTCCACCACTTCTTAGTTGTGTAACTTCACACACTCTGTAAGTCTCGTGCCCCTAATCTGCAAAGTAGGTACAGTGTCAGTG


CCTACTCATTGAGTTTTTGTGGGGACAAAACCAGAGAATGCTTGTGATGTGTTTGTCACTGTGGTCCCCATTACCCTTAAGAAATGT


CAGCTCTTTTCTTTGCTCTTATTACTACATTAGTTTAAACAATGTCTCCCATAGAGGCTGCTCCTGAATTAGTAGTGTATTCTTGCC


ATAAATTACACTTGGGAATAGCCTGATTAATAGTCAGAGATAAGAGGCCTAGGGTGTAAACTCCACCAAATTGTTCAATGTGTGAGA


CTTTGAGTTAGAAGGCTTGGCGAATGTCCTGCCTCGCTATTTGCTGCCTTCATGGGTATAACTAATGTACCTTCTCCTCATCTGTGA


ATGGGGATAATGATGTTCCTGAGCTATGGAGAGGACCAGGCAAGCACTGTGCGTCAGAGCACCTGGCATAGGGCCTGGTACAGGTCA


ATGCCCACCTATTTTCTGTCCTTCCTTTCTTCCTGTTTGTTCAAACCAGGTCTGAGGCTAACAGATGTGTCTTGGTGAGTCCAAGAG


GGTGGCTGGGCCATAAGGGTTGGGGGAGTGGAGAAGTGGGGCTACCAGTTGCTGCTGGCAATTTGCAATATCTACCCTGTCCCAGGA


ATTGTACCCTGGCCTCTCGGGATGATTTAGTATGGCAGTCATGGAGCTGAAAGTTACAAATGGAGGCTCCAGTGATGGAGCTGGATT


TCCTGTTCTATTTAGTCCAGAGCCCATGTGGAGGATCCAAGACAATTAGAGCCAGAGAGTGCTGGAGAAGGCCTCAGTGATCATCAT


CAGACCATCCTTCTTATTGAACAGATGAGGAAACTGAGGCCTAGAGAGAGAAGACACCTAAAAGTCCACACAGCAAGTTACAGAGAC


TTGCTCAGGCAGAGCCACACCCCTGTGTCCACGCCTCTGGTCCTTCTAGGTCTCTGGGGTCACACTGATCAGAATTCCTCCAGCATC


TGCTATATGCCAAGCTTTGTGTTTCTCATTCAATTCATTTACCAAAAATTGAAAGAGTGCTTACACTGTTCCTGGCACTGGGGACAC


AATAATGAACAGGACAGATATGATCCCTGCCCTCATAGAGCTTCCAGGCTAGTGGGAAGGCACAGGGACAGGCAATAACAAGGAATC


AATCAAATAAGTCCGTGTAAATTCAGATGCAGACAAAGAACGGAATGTGGCAGTGATGGGGGGTCATGGAGGAAGAAATGAATTAGG


GTTGTAGCTTCAAGGGCGACCTCTGAAAGTTACTTTGGTATTGTGAGATTTATTTCTATTAATACTTCCTTTCGCTATGTACTACAG


TATTATCTCCTCAGGAAAGTGAGGCTCAGAGAGGTTAATTAACTTGCCCAAAATCACACAGCCAGTCAGTGGAGGAGTCAGAATTCG


AACCCTACTCTGCCTGACTCCGAAGTCCAGGTTTTTTCCACCATCCTTGATTATCTACAGAAATTAGGACAACCTACTACAGAATGT


CAGGTAATATGGTAACCATTAGTATGAGCATTAAGGGACCCCAAGGCCAGACCTGTGAGCCCAGCCTCACTGCTGTCTCTGTCTCCT


GTTCTAGGGGGAGGGACGAGGTGGATATTCTAGATGGTCTTACCCTCTCCTCTCCTTCGGAGACTGGCTTCATTGGGAGTGAGATGA


CACTGTCGCAGGGCTAGCTTTTTGTAGGCCACTACTTGTCGCAGGCTGCTGATGAAGCCAAGCAGATCACCCCCATGTCCACAAGCA


CACCGGGATTAGATACATTTAAGTCCTAGATCCCAAACGCCTTTTTCATTTCTGGTTTTGCATTTGTTTCCATTCTACTATCTTCAT


TTGGAAAACCCTTTCATTCCTCAAGAAAACAAGCCACACAATCAAAAAAAGATGTGTCTTATCCTCTGGGCGCTGCCTCATTGCCTG


CCCCATTATTGACCAATGCCACCGGAGTGCCTTGCACAGCTTGGCCAGCGTTCGCTGTGCACATCGACCAGTGAGCTGGCATGCTGA


CAGCGGCAGGGGCCCCCAGCTTCAGACACTTCTGAACCCAGCTGCTTTACGGACACAATCGGTTGAATCGGTTGAATCATGACTTGT


CTCCCAAACCACAAATTTGTAACTAGTTCACCGTGAGCCTATGCAGCCAGATGAATTGTAACTTGGGCAGTCCCTGCACCTAAATTT


TTTTTTTACCCAATAAAAAATGATATCTAGACATCTCTGTGTGCATGAAAGCATGTCTGTACGTGCGTGTGTATGTTTGGCACCAAT


GGGAAATACAGAGACGTGGAATGCCAGCTCTGCCCTCAACCTCTTCCCAGACGGGTGGGAGATGATATTCTGTGGACTGTAATTCAA


AGAAGACAGACTAATAACAAAGAGCTATGGAGACCAGGGGAGGGGCAAGAATTCAGATCTGGAGTGGAGACCAGGAAAATGGTCCTG


GGAGGCCAGACTCTTGGAGAAATGTGGACCTGGCAATAAGAATTTATGAGCTCTTTCTCAGTCACTGCTGAGTGTATATCTTCCAAG


GTATTTTCCAGTGGGCATAAATTACCTTTCGATTGCAGTATTCGCCACCTCCACTCATCCCCCAACACCAGGTCTTATGTGGACTGT


TAGGGAAGCCTCTAACTTGTACCCTGCCTCCTCACCCTTTCTGCACCACCTCACCTCATCGTCACAGCTGTGAGGAATCCAACAGAC


ACACACACTGGACCTTGTCCTTGTCTGAAAACTTTTGGCTGCTCCTCCTTGTCCTTAGAATACAGTCTAGACTCCCCAGGGGGGCAG


ATAGAGCCCTCCAGAATTGGCCCTGCCCTGCTCTGCGGCCACATCTGTGCCATTTCCTCCTGGAACACTGTGCCAGTCAACCTGGAG


TCCCCTGTGCCCATTACCCTGGAGTCCCCTGTGCCCCACAGGTCCACGTCTCTGGGCCTCTGCATGTACTGCTCCTCCTTCCAAGTG


CTGTTCTCATCTCTTAAGCCTGAGCTGTCCTCCCTGACCCACCCCCACCAACTTTCAGTGCCCCCACGGAGCCTCATGCATACAGAC


GTCTCTTGCTGCACCTCTTATATGCAATATATTCCTCTGTTTACATCACTGCTCATTTACTGAGTTATATGAGGGTGGTCCAGGCCC


GTGCCTCTTTGAGTCCCCATGCCTTATACAGCATCTGACAGAAGGGTGGCTCAGGGAATGTGTGGCACAGCAGTGAATGATGTGCAG


CTTCCACCGTACTTCCAGACATGAATTGATGGTCCTGGAACCTTCAGAGAAGCCTTACCACGTTGTGATCAGTAGGTGGGGGACTCG


ACACTACCACTGCAGAGGTGGCTTTGTGGGGTGGCCCCTGTGTGCGCTCTTATGTTTGCAAAGTGCGTTCTTTCACGCAGTCAGCCT


ACCAATGGGTGACCAGATTCTTTCTTCAGAAGCCAGTCAGAAAAGGGACTTGGCTTCCCAGATTACGCAAAGGCAATCTAATCCCAG


ACCTTCAGTTTTTGGTTAGCCAGCGGCTGCACAAGTGTCACAGACCACAGGGGCTGGGCGACGGGCATGGTGGTCCCTCTGCTTTCC


TGGGCACGTTAGGATGTCATTCTCTCACAGGACTCGTTTCAGAGAATTTTCCGTGTAAATGTGAAAGACCTAAATTTATGCCTGTCT


CAGTAACTAAGTATAGGCTACTTATGGAACCACCCAGCTATGGGAAATCCAGCCATGACAACTAACTGTGAAGAAATAGCCCCCCTT


ATTACACAGAGCAGACATCCTCAGGGATTGGATGAAAAAGAGCTCTCTAGGAAGTCAGTGAAAACGAGCTCCCTGCCTCCTCAGAGT


ATGCCTGGTCAATGTGTGACAGGCTCGCTACTGGGTTCCCATGCTGCATCCATAACAGACATAACCAATCGATCCCAGCATTCTTTC


TAGATGGGCTCAAAGTCCTTCCTCCCTCCAGTGCCACCTCCATGCACAATGCCTAGCCTCAGGCATACTGCTGCTCCTGCACCTCTG


TGAATGAGCCCTCCACAGAGGTCCACCTTTGGTCCATGGTTGATCCATGGACCAAAATGCCTGTTCCTTGTGGGCCTCAAGACAGCT


GAATAATCTACTAATTCAAAGGGAGACCAGAAAGGCAATAGTCAAAGATAATAAAGAGCATAACAATAGTCTACCCTCTATAATGCA


AGTTTTTTCTCCTCTCAGAGGGTCCCTGATCCCATCAGAGGACTCAGTTCTTCACAAGCAAGACTGATCTTGCAGCAGAGGGCTGAT


GGAGTCATTTACATGGAGAGCCAAAGAGAGTCTCTCCCACCAGGACCTTGAGCTCCTTTGAGGTGTGCCTCATTTTTTCATTCATCA


AGTGTTTATTAAGCATCTATGTTTAAGGGCAAGCTCTGGGGAAAACATGGACATAGAAACAGACATGGTCTCTGTCCTCAAGCAGCT


TATAGCCTCAGAACAGGCCAGACATTAGTCAGATAATTGCACAAATGACTGTAAAATTACAACTGTGGTAAGTACTCCAAGGAGCCT


AGATTGATCCAGTCAGAGGATGAATAGGATTAACTTGACATAGAGTGAAGGGAAGAACATTCTAGGCAGAGGGAACAGCATTCGGAA


AGATTGTGTGTCAAGAAGGAGATGAGCACAACAGCCTTGGTGGTCCTGGGAAGAGGATTTGTCTACATTCTACGCACAACAGGAAAC


CACCAGGCAGAACCTCTAGCCCTGGGACAGTGCTGTGCACATTCGAGGGCTGGATGCATCAGTGAGGAACAAAGGCATGCATGGGGG


AAAGGATCCAGTGTGATGGAATGACGGATGCTCTCCCACCCAGATTATGTGCAAACCCTGGAATGAATCCGCCTCCACACTGACTTT


GGAGATCTGGGGCAGGTCGGGTTTCCAACTGCAGGTCTTTAGTATTCCTTGACTAAGTCAGCTTAGTCAACTACGTTAACGAGGTCA


AGTCAAGCTAAGTTAACTACTCCAGCCATTCTTAGAGGTATTTCACTGCAGGCTTTTTGTGTTCTATTTCTGCCTTTCCCCCCACAA


CAGTTGGGTAACAGTCCCCAGCATAGTGAATAAGTTCTGTAAGATTTAATATTGATTTGTTGGAGTTTTTAAAAATTGAAAGTATAA


TTAATGATTTATTGCTACTTTGCAGTTTGCATTAATCACTGTCATTAATGGTAATCCTTTTAGGTGGTTTATAACTTTTAAATGGAG


TCTGTTAATTCCCAAGCCTGGTGGCTTTGTCTCTAGGCTGCATTGGGGTCTGCCACCCTCCCATGCCCCCGACATCCCTCCCCATCA


CCCCATTTGCTTTAAGATACAGGGATGAAACTCCAGGTGTAAACTTTTCAGGGTCAGCCTCTTACCAAGGAACAGACATTTGGGTAC


CTTCCTGGCCAAGAGGAGGGGTGGTGCACAAGCTGGCTCTGGGCCTTTGCTGTGGGCAGAGAGAACCAGGCCACTGCTAGCTCTTCA


ACCCACTACTTCATTTACAACTCTCTGACTTTGTATTCCCTGGTTTGCATGTCTGACACCTCACTTGGCACATGATTTATTACAGCT


TTTCAATAGCCCGTTCTTTCTGATTGACCTGTCCATCTCCATTTGGAGTGGAAAGATTGGCTTCTAGGTGTTTGTGGTGAGAATATT


CCTGAGTGCGATGGTTTGGGGTTAGGAGCTTCCTGCTCTTGGTACAGAACCGAGGACCACAACTAAAGGAACTCCCCTTTCTCTGGC


TGGGAAATGAAAAGGGTGGGGAAATACACACTAGAAGTTGCCTGAGACCTGGCTGAAGGAGAGAAACTTTCTGTTTTGCCAACACCT


TCAGGGATAGAAAAAAAATCAAACTTCTGCCTGCATCACAGGCAAGGGAAGGCAGCTCAATGGAAACAGCATGAAAAGAACTTCGGA


GCCCATATAGGTCAATCCCCTGCTTCTGGGGTGGGCATTCTCTCCCACATGAATAGGTCCAGATTTCATTTTGAAAACATTTCCCTG


GGAGGAATCTTCCCTCAAATTCTCTCTCTTTCCGTCTCTACCCTTCTTCAAGGTTTGACAATCTCTCTAACCAAAATCCCTCTTGCT


GTAGTTAGAGCCTCTTAGGGACCAGTTAAACTGGAATAAGGGATGGCCATAACAAAACATGCAAATTCCTTTTCCTTTTAAAGAGAA


ATATGTCTCCTGGATATTACCTGAATAAACCCATCAGCTTGCTGTTACTTTTCTGGGATTATACTTGATGAGGATGGTTGCAGAAAG


TCCTGTAAACATCTTCTATAGTCTGTATGGGGAGGACAAGTCCCACCTGTTTCCAGTGGAACATTCTGATTCCTGTTGTTACTCTAT


ATTTACAGAGTGGGCTCCACTAAGAGCCCACCTCCTTCTGTCACTGGTGGAAAGGCTATTTAATATGATCCCAATTAGAGGGAGGAG


GATCTGGGATGGTTGTTGGAACATGGCAGACGGGGGAGACCCGGAGGGAATAAACCACCCCAGGATGCTGTGTGACCACCTGACCCT


CTGCAAAGCAGCATCGTGGCACTCTGTTCCCTTTCAAGGTTCCCACAGTGAGTGCCACCCATTTTTACCACAATGGCAACAGGATTT


ATGCTCCCACCCACTCTCAGTTCTGAACTTTCTATGGCTTTGCCCCTCATTGGTCATAAAACACGTGTCACCTGCCTCTCTGACTTG


GCTTTTCTTGCAATTACATGGTTTCCTTTGCGATCTTCCTGGCCAGTGGAAGCAGAAGGATGCTTTTACAGACAGGGTATTATAGAT


GGGTTGGCAGATGAGGTGATTTCTGAGGGCCTGGCACAATGCCCAAAGGGACGTGAGTCAGCTCTCAGAGGAGGTTTGGTTTTTCCT


TCCAAATTCATACAAACAGCAGTGAAGTTTAAAAGATCCTCAAGTGGATTACAACCCCCATTCATTTGGCAGCAGAGGAGCACAACT


GTCAAAAAGTCCAGGTACTTTAAGCTGTGGAAGAGGCACAGAGTCACTCTCAAGTTGGACAGGGCTTCAAGCTATTTCTAAAATTAA


CATCGGGGCCTTTCGTTCCCTTTCGAGGTTCCTTTGAGGAATGGGTGAAAGCCACCTCTTCTTGACCACAGCAGTGACTGGATTTAT


TTTTGTCCTGTCTTCCTCCTCCACATTCTCAGTTCTCGAGGCTTTTTATTGTTTTTGGTTTTAGCCAGGCTTGCGCTGGTTGCTTAC


TCTCCGGTGTGCAGGGCTTCTAGAAGTGTTAGCCACAGCCAGCGGGAGGCAGCCGATCACCCATCCCACCTGCTGAGCTGTCGCGGG


CAGACATCTGTTGAGCTCCTCCCCAGCACCAGCCGCAAGAATGTACCTGATGTGGTCTTTGCTCTGCAAGAGCTCTCAGTTTAGAGC


AGTCTTTTTGAGAAAAAAAAAAAAAAAGTGGTATGATACACGTAATATAAAATACCATCCTAACTTGTTTTTTTTTTTTTTTTTTGA


GATGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGACTCGCTGCAACCTCTGCCTCCCAGGTTCAAGTGATT


CTCCTGCCTCAGCCTCCCTAGTAGCTGGGATTACAGACATGCACCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGT


TTTACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACTCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCG


TGAGCCACCACACTTGGCCTCATCCTAACCATTTTTAAGTATATAGTTCAGTGATGTTATGTTTACTCATATTGATGTGCAAACAAT


CTCCAGAACTCTTGTCTCCTGCAAACCTGAAATTCTGTACAGTATATACATGGGGGATGTGTTCCAAGATCCCTGGTGGATGTCTAA


AACTGCAGATAGTACCGAATCCTACAGAGAGAGATAGTCCCAGATTTAACGATGATTTGACTTAAGATTTGTCGACTTTATGATGGT


GTGAAAGCAACACACATTCAGCAGGAACTGTACTTTGAATTTTGAATTTTGATCTTTTCCTGGGCTAGTGGTATGCGGCATGATATT


CTCTTGTGATGTTGGGCAGCGGCAGAGAGCCCCGGTCAGCCCTGTGATCACGAGGGTCAGCAACTGATACAGTACTCTACCGTTTAC


AGTGTTCAGTAAATCACATGAGATATTCAATGCTTTATTATAAAATAGGCTTTGTGATAGATGATTTTGCTCAAATGTAGGCTAATG


TAAGTGTTCTGAGCACACAAGGCAGGCTAGGTTAAGCTGTGACATTCGGTAGGTTAGGTGTATTAAATGCATTTTCTACTTACAATA


TTTTCAATTTACAACGGGCTCATCAGGACGTGACCCATCATAAGTTAAGGAGTATCTGTAATGCTGCAATGAACATGGGTGTGCAAA


CATCCCTTTGATACTCTGCTTTTAAAAGCAAGTGTTCTTGGCTGGGCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCC


GAGGCGGGCAGATCACCTGAGATCAGGAGTTCGAGACCAGCCTGGCCAACATATATGTTGCCATATATGTAGCGAATCCTCATTTCT


CTACTAAAAAATGCAAAAAATTAGCTGGGCATTGTAGTGCATGCCTGTAGTCCCAGCCACTTGGGAAGCTGAGGCAGGAGAATTGCT


TGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATCGCACCACTGCACTCCTCCAGCCTGGGCGACAGAGCGAGACTCTGTCTCTC


AAAACAAACAAACAAACAAACAAACAAACAAAAAAAGCAAGCATTCCTAACCTGGGGCCCGTGAACTCCCAGAAACTAGCTGCAATA


CATGGTGTGTTTCTGTAAATGCTTCTTGTTCTAGGGAAAGCAAATTCATAGCTCGCATCAGGTTTTCAGTGGGCTTAGGATGTCAGG


AGGGCTCAGTCTAGAGAGTAACAAAAGCAGCACCTCCTTCGGAATCCCCCAAGGCCCTGCCTGTCCTGAGTGCCGCCTCTCCGATGG


CAGGGCAGGTGTGAAGGAGCAAGTCATTCACTTCTTGGTTCCTGTCCCAGCTGTGCCATTTACTACCTGGGTGACACTTGGCAGTTC


AGCTGACGTCTTGGACCCCTAGTCTTCAAATCTGTAAAATAGAAATAATGACAACGTCTTCCTAGGATTGTTAGGAAGATTAAACTA


GATTTAGCACAATGGTCAAAAGCATAATGTGGTAGGCTGAATCATAATGCCCCCCCCTGCCCCACCGACCACCACCCTGCCAAAATA


TCCAGCTCCTAATCCCTGGATATCCTGGCAAAAGGGACTTTGCAGGATGTGGTTAAATGAAGGATCTTGAGATGGAGGAGAGTATCC


TGGGTTATCCAGGTGCGATCTAAACGTAATCACAAGTGTCTTTGTGAAAAGGGAGGCAGAGGAAGCTACCGAAGAGGAAGCAGGACG


AGTGATGGTGAAGCAGGAGGCTGGAGTGGTGGGAGAAGAGGCTACGAGGCAGGGAAGGCAGGCCCTCTCTGGAAGCTGGAAAAGCAA


GGAAACGGATTCCCCCGCCTGATCTTCGGGAAGGAGCCAGCCCTGCGGACAACCTCCACGTTAGTCTAGTGAAACTGATTCCACACA


TCTGGCCTCCGGAGCTGTAATATAATAAATCTGTGTTGTTTTAAGTAATGTGTTACAGCAGCAATAAGAAATGAGTGTACGTGGACT


CTGGGGCCAGACTGCCTGGGTCTGAGTAAACCACTTACCAGCTGTGTGACCTTGGGCATGTCACTTAATCTCTTCATGCCTCAGTTT


CCTCATCTTTCAATAATAAGGCCCACCACAAAAGGGCTGCTATGAGGAGTAAAGAAGCTAGTATGTGTAAGTCATTGAGACTAGCAC


CCGGAACCTAGTAAACGCTGTGTTAAGTATTTGTTAAATAAAATAACTAAAAAGCACGTGAAGGTGGCTGGCTCACAGGAGGCTGTG


GGGTGATGCGAGTGGATGCTGACGGGTTTGGCGGCGTGGGCTGTGCTCCGTGGAGTCAGTTCAGGAAGGCAGGGGAGTATTTGGTGC


CTCTCAGGAAGACTATGGTAATCTTCATGAAAATGAACCATGGATGCTTGAAGGAATGAACCCTCCATTGTCTGTTACACTGAATGC


CTCACACCCTGCATTTCCCAGTGTTCCTTGAAATATTAATAGCTGTTACTTCAAAACAAGAGTCAAGGTCAAATAAGTTTGAGAAAC


TGCATTTCAAAGCCGACTTGTTTTCTTTTCTTTAGAAGTCTCAGAAGCTTTAATATGCTAATGAGCCTGATGAATCTCTGAGAAGCA


TTTTTCAAACATTTGGCCACTCAACCACTTTGTATGGTGCTTCCAACATGGCCAGCACTCGGCAGAAGGCGCCTCAGAGCAAGCCTG


TATACCTGTGCCTGCTACAGAGGTGTGTGAAGGTGGGACAACCCATCTGAGAGGCAGTGTCAGGGGCCTGTTTGCCTGACCTCAGAA


CTAACTAGAAAATGCAGCTGCTGCTGCTCCTGTCATTCATATCCCAGACAGTCAGAAAGGGTTACCGACAGGCCCATCCATCCCTGT


TTCCTTCAGGGCCTGGGCCAGCCTCCAGTGGAGGCGCCTAGACCCTGAGGCCCCAGACCCTAGCATGCCCCTCTCTTGCCTCCCTCC


TGACCCAATCTAAGACCCTGAGGGCACTGTGGATGCCACAGCCCTCAGATCTAAACTTCATCCTGCCCCCTCCTCCAGCTACCCCTT


GGCTGCTTCTCAGGCTTAGGGATGTACCTACCAGCAGCCAGCGTCAGCCTATGGGAGGACAGAGAAAGTGGCAGCGTGGGCCCTGGA


AGCAGGCCTGGGGCCTTTTTGGACAGGGGACTCTGGGCGTCTGGATATCCAAACGGGGGTTTAGAAGGTGGAGGCAGACAAGGCCTC


TTGGCCCTGTGGGCTTCTGACTCCACGGGGTGTGGTGTGACTTAAGGAGGGGTCAAGCAGGGCCCTCTAGTGTGGGGGACCCAGAGC


CAGAGCTCCAGGTGTCTGGATCCAGGGCAGTACCTGTGGGCATTGAACACACAGCAGCACAGACCCCGAATTGCAAATAGTGCCCCC


AGTCACCAAACTGGCCCTCTCCATAGCCATATCTTTGTTTGCTTCTGCGCATCTCTAGCAGACACGCAGTTCTAAGCTCCTGGTTCA


TCACGAACTTGCATCCTGATCTCCGCTGTACCCCACGGGTCTTGGCATTGTACCTGGCACGCTGAGGCCAGATCCGCAGTGACCTCT


CACCAGCAGCAGTCGCTGTGGTGATGGTGGCTGCCGCATGCCCTGGCCCTGGCCCTGGCCCTGGCCCTGGTCCCTCCCTCCCAAATG


GAGGGAATGGTGGAGCAGGTTTCCTTTCTCAACCGTGGGGAGGGCCACCACTTCCCACAGGGAGCCTAGGCCTCTGCCCTCAGTGGG


GGAGCGGAGTGGGCCACTGACTAACGCGGCTTTCAGTGCCTACGATAGGAATTCACATGGAGAGGTGGCCTTGAAATAAGTGCCTTG


TTTAATCTTCATGCCCTGGAAGTATTTTTCACAAGGTGGCTTAGTTAGAGGGGCTGTGGATCTGGTAATGAGGCTGGCCTTGGAGGG


GGAGACTTGTGAGAGGAGCTCAGCTATGAACACTTCTAGCAGGGCTGTATTCATAAAATCCTGGGGGCTCCCAGGGGATTTGAAGCT


CTACACAGAAAATTACAGGGCAGGAAAGGACCTGGGCAATTATTTTTCCTCCAAGAATGGCCATGCTTAAAACATCACCATTAGGCG


CCACAAGTGGCTTTCTCCATGACAGCTCTTTTAAAAAATACTTTATTGGGTTTTTTTAAATTACAAAAGCAATATAGGCTTCTTTTA


ACACAGAGGTGTGTTCTCATTATCAAAAGGAAAAAAATCAATAGGTTCCCTGATTCCCATCTCCCTGCGTCCCCAGTAGTACCAGTG


TTAACAATTTAGTGTTTAGCCAGAGGTGATTAATGCACCTTTTGTGTGTGCTTATACAAAAATGTACCAACATGCATACACATATAT


GGGCATTTTTGTTTTTATGTGTTGGTGTTTGCTTTTTTAAAAAAGAGGAATCACACTATACCCATTATGCTGTAAGTTTCTCTTTTT


ACTTAGCAATATATCATGAACATTTTCTAAGTCAATACATATAGATCCACTTCATTTTTAAAAACAGCTACATAATGTTCCCCAGTA


TGAGTACCATAATATATTCAGCTGTTTCCCTATTGATGTGTATTCAGGTTGTTTCCAGGGTTTTTTAAAAAATTATAATAAGCAGTT


CTTTTAAAATATTCTTTGATTTCTTTTTCTATCTTGTGCATATGTTACAAAAGACTCTTTTGCCTTAGGAGGATTATAAAAATGGTG


AACAATTAAAATATTTCTTTACAGTCACATTGATATAGTTTTGACACCTTAAACCCTTTATGTATTCATTTGGGTGGCCCTGGGCGC


TGTGCCTGGCACTGTGGAGGACAGTGACCAAGGAGATGTCTGTCCTCAAGGACCCCTGCTTTAGTGAGGGTGCTGACAAGCAGGTGG


ACAGGAATGCGGCTCAGATGGACGATCAAGAAGGAGGTTTCGGCCAGAATGGAAACTTAATAGATGAGAGTGTGGCCTCTTGGTTTA


AATCCTGTCTCCACCACTTAGTTGCTATGAGGTCTGGGGGATGTTCACTTTTCTTATGGGGCTATTGTGAGACTCAAAGAGTTGATG


TAAAGAAAAGTGCTTAGGAGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGAAGGCCGAGGATGGCTGATCATATGA


GGCTAGGAGTTTGAGACCAGCCTGGCCAACATCGCAAAACCCCACCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGCAC


AGCTACTCGTGGTAGCTGGGTACTAATCCCAGCTACTCGGGAGGCTGAGGCAGGATAATTGCTTGAACCCAGGAGGCAGAGGTTGTA


GTGAGCCATAATCGTGCCACTGTACTCTAGCCTGGAAGACAGAGTGAGACTCTTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAGA


AAAAGAAAAGTGCTTAGGCCCCAGCCAACAAGTTGGACTCACCAAATGGCTTGTTGCTGTTTGAAGTGCTGCCCCCGCCACTGGGAG


ATCAGGAAAAGCTCCCCCTGAAGGGGTGACAGTGCAGCTGGCCCTTGGGAAGGAGGTGAAGGGCCTTTTAGTCAGTTGGGGAAAAAA


CAAACACTCCCTGCCCACCACCACCACCTGGTCCTGACCTCAGTTCTTCAGCTCCCTAGGCTGTTCAAAGATCCAAAAACCTATTTA


TTTTTAGTTGCTAAAAATATCCCCTAAGCCAGGGTTAAAGAATTTCTCCCTTAGTGGTAAACAGGTGACTTAGAACCAATCAGGGCC


CAGCAGCCCCAGTGATGATGCTGTTCCTCCCCTACCCCCAAACATTCAGCAGGATCCTTTCATGTGTCAAAAGGAAAGAAACTTATC


AGAAACTTCCTGTTGAGAAAACGATACCTCTTACCCCAGACTTAGCAGATGCACAGAAACCTTTGACTCCTGGATCTGCCAAGGCAC


ACAAAGAACCAGAAACACCTATTGGCCTGGCCTGGGATAGGCAAACACTGGGGCTCAGCCCAACAAGCCTTCCTAGCACAGCCTGGG


GCAGCACACACAGTAGTCAAGAGAGCTGCCTGCCCTGGCTGTAGAGCCTAGGTCTGCCCCTTATTAACTGTATGACCTGTAGTAAAT


TATTTAGCCTCTCCGAGCCTCAGTTTCCCTGTCTGTAAAATAGAAATAAGAATACCTGTCTCAAAACCCTGTTAAGGACTAAATGAG


ATGGTGCCTGTAAGGCACACAGCACAGGACCTGGTGCACAGTGAGGCTGCAATACATGGCCCCTGCTGTTACCATTGTTAATGGAGA


CCGCCGCCCTGCTCCCTCCGCCCCCTGAAACGGGGGCTAGCACTCCCCAACTGTCTGGCCATCCTTCTCCAGCTGCCATTTGGGGAT


TGGCTCTGTGACAAGCAGGGGGCACAGGGCCTGGGGAATACTGGAGGAAGGCACCCAGCCCCACCTGGGAGTCAGAAGGGACCAGCT


TAGGCCTGTGGAAGGGTGGGACGCTGGATCTGGAGGTCTCTGGTGAAGAAGCTGAGAAGAGGGAGTGCTTGTACAGAAGATGGAAGG


GCGCAAGCTTAGGGGTTACTGGTAACTTGGTTTAGCTGGGATGAGACACCGGGTGTGGCAGGTGATGGGGATAGAGGGGCCAGCTGG


TGCCAGGTGGGAAAAGGCCCTTTTGGCCAAGTGCAGCTAGGAGGGTGGACACTCTGGGTTGCCACGGAAAGGTTCTAGAAGGGGAGG


TGACATGATTTGGTTTGTATTTTAGAACATTTGCTCTGGCAGCAATGTAAAGATGGCTGGGGTGGAGCACATGATGAGACCAAGGTG


TGGCCACAGCAACCCAAGGATTGGCCGGGGTCACTTGGCCTTACTGCTTCAAATATAATTGGTTACAAACTCCCACCCCACACAGGA


GGGGACCCGGTGTCTTTCCACTGGTCTCTGGGGGCTTGGAAACTTCCATTTCTCTCTTGACAGCTCATCTGATGCCAAACTCTTTCT


GCTGAATTCTCCACCTCCATCCTGTACTTAGTAACCGCTTTAGGCACCCTTCCTGTTCCTGTTGCTCCTCGAGGGACCCATGACCAA


GGCCTCTAGGTTAGCTGACATTTCCATGGATCTGGAGCAAGGGGAAGGGGTGAGGTGGTGGTGGCACAACAGATAAGACAGCGCTGA


ACGCCACATGCTCCTGATCTTACAGTCTCAGCACTGTCCCTGTCTCATGGGTGGTCAAGTCCTCAGTGGGCTCCGGCCTCCCCCTCT


CATGGGACTGGCCCAAGGTGCTGCTTAGCCAGCTCCCCTCTCCTTCCAGTCCCACAGCTCACAATCCCCCATCTCCAGTGTTCCTGT


TCATTTCTAGGGCACATATATTAAGCCCTGTGTTGGTCTCCTCTGACCCCACCCCAAGCCTGTCCAGAGGAATCTTCTTCATTAGCA


AACATGCTGGGGTGCATAAGTGGGCTCCTAAACTAAGATGGTCTCTTCCTCGCTAGGGACCCCATCACCAGGTCTCCATAGAGGCCT


GTTCACTGGCGGGAAGAGGAGGAAGGGAAAGATGATAAATGGATATTGTATCTGTGGAAATGAAAGCCGTGGTCTTAGTTCCACAAA


CATAGCCCAGTCTAGATTACAGATAACGATGTGGGTTTCCCAGGTGGTGTGGACACCAGGGATAGAACCCAGTTTATTTTAATCATA


TATTGATTCTCTGGTCAGCAAAGATTCTTCTGAGAATGAGCATTTAAAGGGTGGGCTTGAGTTTTCTTTCTTTTCTTTTTTCTTTTT


TTTTTTTTTGAGATGGAGTCTCGTTCTGTCACCCAGGCTGGAGTACAGTGGTGCGATCTCGACTCACTGCAAGCTCTGCCTCCCGGG


TTCAGGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCACCACCACGCCCGGCTAGTTTTTTTGTATTTTTA


GTAGAGATGGGGTTTCACCGTGTTAGCCAGGATGTTCTCAATCTCCTGACCTCATGATCCGCCCGCCTCGGCCTGCCAAAGCGCTGG


GATTACAGGCGTGAGCCTCCGCGCCCAGCCGAGTTTTCTTTAGAAGACAAAGTAAAGCCCAAACTGGCCAGCCCCCAAATAGAGTGC


CTGCTTAGCAGGCTGGCAGGTGAAAGGGCGTGGGACTTGGAAGACACAGAATGCTGCAAGCCCCAGGCAATTGATTGAACCTGTCTT


GGTTTGGGTTTCTTCATCTGCTAAATGGATGTATGACTCCCTTACAGGGACATTATGAGATGGCAATGAAATGGTATGTGCAGAATC


ACCTGGCTCGGCCCACAGTCTGGCTTTTGGGTAATTTTGACACAAAAGGAAATAGCTATGAACTGAATTGTGTCTCCCCAAAACGCA


TTTGTTGAGGCCCTAACCTCCAATGTAACTGCCTTGGAGAAAGGGTCTGTGGGAGGTAATTAAGTTTAAATAAGGTCATAAGGATGA


GGTCTAGTCCTATAGGACTGCAGCTCTAGGAGAAGAGAAAAAGAGAGATCCCTCTCCCTTTCTCTGCCATGTGAGGACACAGTGAGA


TGGCAGCCACCTGCAAGCCGGGAAGAGAGCCTGACCGTGTTGGCACCCTGATCTCAGACTTCCAGCCTCCAGAACTGTGAAAAAATA


CATTTCTGTTTTTTGAGTTACCCAGTCTATGATATTTTGTTTCGGAGGCCCGAGCTGTGGTGCATATTTAACCTGTGGGCAGTGTGT


TTTCAGAAAGTGGTGACATGGTGCACATGGCCCTGGTGGGAGTGGGTCTGTGGTCTCCTGTCCTTTGAGGAAGCTCCTTCTGTGACA


TCCAAGGTCCCAATGATCTGGGTCCTGCTACCTTCTTGGTCTCACCTGGTATCATCCCTCACTTCTTTCTCACATTGGTCTTCTTTC


TTTTATCTCTCCAACTCTCTAAGCTCCATCCTGCCTTGGGGTTTTTGCACATGCTGTCCCCTCTGTAATGCATACCTTTGCAAGGCT


CACTTTGGATTCAGAGGTCCCTTCCATAGAGAGCCCTCCCTGTCCTGGCTGTCTGGGACTTCTCTCATTTCCTTTGCCCTGTCTTAT


TCTCTTCCTGGCAGGCATCACTCTCTAAAATTAAATGGTTTACCTGTTTAATATCTGTTTTCCTCCCCTGAAATGTAAGCTCTGTGG


GGACAGGGGCCTTGTCTACTTGTCTTGCTATATCCCTAGAGCTTACCAAGGACTGTCACATAATGGGGGCTCAACTCATGCTCAATG


AATGAATGAGTGAATAAGCTGATCGGGGCAAAGCTCCCTGCCTGTGCATCGAGCACCTCTTGAACCAGACCCCAAACACTTGATTTC


CAGCATCACACCTTGTCTCTCCTTACAACTAGAGACCAGCTGGTCCATCCAAAGGATTTCCAGTCAAAGGGTTCTATGGAGAGCATG


GGGTCCACTACAGAGACCTAGGCTGGAGGAGGAGGTGAGTGAGTTGATCTTTGAATGTTCTTCTCTACCCTTTCAACTACAACAGCT


CTGAATTTGTCTGTTTCCCATGTTGGGCGTACATGAAAAATCTTATGAAAGAAATGGCCCCACAGCCCAGAGAAAATGGAAAACCAC


AAATTGCATCCAAGTCTTCACATTACACTGAGGAATCTGAGGTCCAGAGACTTGCCACACACAGATGGCCAGAGGTGGGATGCTCTA


TCCCTAGTCCTGACGTGCTCAGGGATCAAGAAATTCCTGCTACGTGAGTAAAAAATAGTGGCTCGCTCAAATGCCGAAACTTGGCTT


TCTTTCTCTGAGAACTGAGGACAGGGGAAAGGATTTATGATCACCACTGGTCTCTGTTAGTCCCAAACAAACTTCAGACTCCATAAC


CCCCATGAGTGGTCATTACACACTGCAAGAGACCAAAAGTGAGCTCTGGCGAAGCGCTCAGGAGAAGCCTATCCTGGCCGGACCAAA


GAGCCACTGTGGGACATCACACATGGCCCAGGGAGTGGGATGGTTTCAGATGAGGACAATTTCTTCTTAGACACAGAGCGGGGTAGC


GTGGACCCCAACGCCCTAAGCATCTTGTTTATGGTAGAATCATAGACTTCCCTGACAAGGCCTGTTCACTGGCTGGCCTCTTTTAGA


GCCACCATTTTTCCACCTTTGCTTCCCAACCCCCACCCGCCTCCCTTTCTTCCTCTAGTTCCATGGAGCATTTGCTGACTGGTAATT


TTACCAACCATTGCTGCAAACCCAGAAGTTCATTTCGTCACTGGCAATCAGCTCCTGTCCGCAGGGAAACCTAATTAGGTACTACAG


GATTTTTGATGTTGCTTCCATGGTAACCCCCGTAGTAATGGTGTACATGCAGAATATATGCTCCAGGGTGTTTAAATTTATATATGT


ATATATATATATATAAAATATAAAACATATTGTATATATAAATAATATATCTTAAGAAAATCTGTAATTTTTTCTTCTTGCTTTGTT


TCTGTGTCGTTTTTTTAAATGATCGAAATTTTCCCGGAAGTTCTTCTCCCCACAGAGAGAGAACAGTACACAAAAAGGCTTTTTCCA


TTTTCTCTCCCTTAATTTAGAGAAATTCACAGTTGTGCAAGAGTGAAAGTTTTTCAGGTTGGTCAGAAAGTGTCTAAGCAGGAATAC


GCTCTCCTCCCTGATAGCTGAGAACATTTTAATGACAGATTTTGCTTAAATAAAAAATCAGAAAGGTCTCAAGTCTTTCAAAATAGA


ATGGGGGGGAAAACGAGTGAATCCAATGAATCGACTCTAAACTTATCCTAAAAAAAAAAAAAAAAAAAAAAAAAGGAAAAAAAGAAA


AAAGGCAAGCTTCCCTGCATGCCTACCCCTTTGCAGGAAATGTGGGGAGGCCTCGCAAGTCTGAAGCTCGGGCTGTGCCATGTGGCT


GCTGGAGGCACTGGGTAGTGTCCTTGTCTCCTTGTCAAGGCAGCCTGTCCCAGGCCCTGCAGAGATTGCAGCTGAACGGCCCTGTCC


TGAGGTGTCCAGATGGCCTTCAGCGTTGGCCTTGTGGTGAGCTGGTGATGACATCTTTGCTTGGCGAGACACTCTAACCAGGGAAAG


GTCAGACCTGGACTCCCTGAGGTGCAGGTGACAAGGGAGAGGGCCTGTGACACACCCACAGCTGAAAGCCAAGGGCTTCTGAAGAAT


CCCTGAATAACTGAAAGTGCTTTCTGTACTATCCCTCGCTGGCCGTCCAAGGATGGAATGCCATGCTGACCTCTTTGTTAGCTGCCA


GCGAATCCATTTACCCTCAGCATTTGCCAACAAGGTCCACTGCTCCCAGACTCCCTGCTGTTTTTCTCCAGCGGCCCCCCTGCCCAT


TAATTCTGTTGTGCCCTTGTTCCCTGATTCAGTCTACCAGCTGACTTCCTCACATCTGAGAAAACACTTTGTATGCAAAACAACTAA


ACTGCTTGCAAAATAACTTTTTAAATGCTCTGAGTTATTCTTTGATATCTCAAATCATGTGTCCATGGGGAGAGTGGGGATGGGGGA


ATGGCCATCAAGGAATGGCCCTTGACCCTGATCTCCTCCCCATCCAGTCACCCAGTTACTTGAGAAGGACTGGCCAGCAAATATAAC


TGAGTGGAGTGGGAAGGTGGGGACGGGTGAGGGTTCCTGCTAGGGGCTGTGGCATAAGAATCTAAAAGGAAAATGTTGGGCACAGTA


GGCACATGACCTGGCTTTTCTAATATGTGCCAAATATAAGAATTAGTTTTGTTATATATTAGTTTTGTTGCATAACAAAGCACCTCA


AAACATAATGGCTTAAAATAATAATTTAGGTCACGTTTCTGTGGGTCAGTCATTTGGGCTGGGCTCAGCTTGGTGGTTCTTCTGCTG


GTCTCACCTTGGGTGAGCTTCTGTCATGCAGCTGGTCTAGGACGGCTTCTGATGGCTGGCAGCTGGTACTGGCTGCAGGCTGGGGTG


AAAGGGATAGTGAGGCCATGTGTCTATAGTGAGCCTCATGGCGATGACATTTTTTAAACCTCTGCTGTATCACACTTTTTAATGTTC


CACTGGCCAAAGCAAGGTACATGGCTAAGTTCAGACGGAAGGGATTGAGAAATAGGCTGTACTGGCCAGGCGTGGTGGCTCATACGT


GTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACTGGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCC


ATCTCTACTAAAAATACAAAAATTAGCCAAGTGTGGTTGTGGGTGCCTGTTATCCCAGTTACTCAGGAGGCTGAGGCAGGAGAATCG


CTTGAACCCGGGAGGCAGATGGTGCCATTGCACTCCAGCCTGGGTGACAGGAGTGAACTCTGTCTCAAAAAAAAAAAAAAAAAAAAA


AAAAAGAGACAGAGAGAGAGGGAGAGAGAAATAGGCTGTACTTCTTGATTGGAAGAGAGGCAAAGTCACATGTACAGAAGTAAGTGA


ATGGGATGGGAGGAATCTGTGGCCTTTTCTGCAAGCTGCCCCCTCTGGTGTGTCTGATGCATGCCTTCCGGGCGCTGCTGAAGCCCT


ATGTAACCCAAGAAGCTTTTCAAATTGCATCCTAATCATGCATGTCTTTTGCTAGAACTACTTGAGATTGTGCACTGATTCATGGGA


CATGTGTTTGATTCAGATTTATATACCCACAATGGCCTAACCTTGTTGATTCTTAATAATTATTATATTGAACTGAGTTGGGTTAGT


TCTCCTTTTTCTCTAATTACAAGCTCCTTAAAGGAAAGTTTGGAATCACTGTTGCATAAAATCTCCCTCCCAGAGCTCTCAGAATTA


TACTAACGGCTGAAAATCCGGCAAGTTCTCAGAACCACCAGTTAAGTGGTAGAGGGATTAGGCCTAGAGCCACCTCTGGACAGAGCA


ACTATCTGAGGAAAGAATGGAATTTTCAGGAAACCAGAGACTGTGGTACTGACACATTGCATCTTCAGGTCAGTCATACCCTCAATG


AGTGAAATCACTTTTTTAGGCTTAGGAGGCAGAAAGAGTCAGTGACTCGAAGAATGTGGCTTTCCTTTTCCCATTCAGGGAAGCCAG


AGTACAAGGAGCAAACCTATGCCTCATCAGGAAGAGACTCGTTTGTCAGCCCTGGGCCTCTGTGGCTTCTCCTGCTCTGGAACAGGC


CAGAACAGACCACTTGAGGGCCCACGGTACTCCCTGCCCCATGCCACACTCTGTCCACATCACCTCAGTACTTCTCCAGAATCCATC


AGAGGCCAACAGTCAAGCTGGTCTAGAATCAGGGCTGGATGACTGAGACTAAGCCCTAGGGGAGGATAGTCCTTTGTGGAGCCACAT


ACACACTCCCCGAGCCCCTCTGGTCCAGTGCTACTCAAGATCCTGGTTCCAGACTTGCTCTAGAACTTTCTAAGGCTTGGAGGTCAC


CTGGGACAGTTTATTCCAGGTTGAACCACCCTTTGGGAATAAGAGGGTGTCCCTTCCCATGGTGTGAGATGAATTGTCAGGTCCTTT


GTGAGTCACAGGCTTAGGAATGGATTTTCAACAGGAATTTCCATTCTGGGTGGTTAACAAGGGCCACAGGCAATCTGTCCTTTTCTT


CATATGACACAGTCATCCGCCTACACACCCCTTTATTCACCAAGATTCTACTGACTGCCCACTCTGTGCCAGGCAACGTCTCAGGCA


TGGGAGTGGGGTGAGATGAGCCAGGCACGGTTCCTGTCCCTGGAGAGCTCAGGTGCACCGAGAACACAGATGAGGCAGGAGGTGCGA


GCAAGAGGGTCTGTGTAGAACCACAGAATTATGGCTTCTTAGAGCAGGAGGTACCTTGGGGATTGTCTAGTCTATTCCCTCATTCCT


CAGAGGAGGACGCTGAGCCCAAGAGAGGGAAGATTAGTCCAGGGGCACGCAGTAAGTGGGAGTTACTAATTCACTAAATAAGCATTT


ATTGAACACCTACTAAGTGCTAAGATCTGGGCTAGGCTCTGGAGATGCCACAGGGAACAAGGAAGACACAGCGCTTGTCTCTTTGGA


GCTCCAACTGTGACTGGTTGGGGGGTCCCAACCCTGGTTACATTTTAGACTCACCTGGGAGCCTTAAGAAGAACACCCGTGCCAGGG


CTCCACCCCCAGAGATTCTGATTACTTGGCCTGGGGTGGGCCTGGGCCTGGGCATGGGTATTTTTGAACAAGCCCTCCAAGTCATTC


TAATGTGCGACGCAAGTAGGTTGAGAACCATGTCTAAGGGGAGAGACAGCAAAACCTCACACATGCAAATCAATAATTGGGATTGTG


CTTTGTTAGGAATGAATGGGACCCAGAGTGAGGAAACAGCAGGGTTGGGGTATCTGCTACTTGCTCTGAATCGGGAGGGAGCGAGGC


CACACTTGGAGAGCTGTGATTCCAAGGGTCAGAAGGAAGGAAGCATAGAGTGTCCTCACGTGGGACAGCAATGGGATCTTCTGGGAC


ACATCCCACCCTGCAGATGCAGAAAACCTTGCAGCGGAGCCCTGTCTAGCAGAAGCTTTTAACCTGCAGCCTGAAAACTCTCCCCCA


CCCCCTACTCAAAACACCCGCTCTTTACACACACTGTTTACGAGTGCCCCCAGGCCAGCCAGCTTAATAATCCCTCACATTTTTAGA


GCAGTGAGTAAAGCACTGTCCAACTTTTTATCTGTATTATTGGATCCTAACACTAACCCCAGGAGGCAGGCAGGGCCAAGGTCAGTC


AGTGTTCCCCTGTTGGAGATGTGGAAACAAGCTCGGAGAAGTCACGCACGGCCTGAGATCACATGGCTAATACCTGGATGTGGGGGA


CTTCAGGCTAGCTCTCCCACCTCCAGCTCCACTACCCCATGTGGCCCCCACCTTCCCTGCACCAGCAAGCCACAACCAAGGCGGGGC


ACCTGAGAGGCAGCTGGGGACCAGCACCCTCCCGTCTCGCTGGGCAGAGCTGCCGGTGCATTCTCCCCTTCAGCTCTTACTTACAAT


CCCACTCCTCATCAGGCAATCAAAGGAATCTGTTACTCGTTGCTTCCATTCCTGCCCAGAGTGAACCCAGTTACTATAGTAACCAGA


TGCGATTCTTTATTACGGAGTAGATGGTTTTAATTTTGTATTTGAAGAGTTTGGCCAGGCAGTCACGTTGCCATGGCTTGGCCTGTC


GGGCGGCAGTTAGAAGCAGAGGGAACCCTTTGAGCAGCCATTAGGGCTTTCTAATTGCTGGGGAAAACCTATGTCTGGAAAAACCCA


GGCTCAGCTGCACTGGGGAAGGAGGAGGGTGAGTCTCCAGCTGGTGCTGTGCTGGGTACTGTCTCCTGTTCAGAGATGACAGCTCCC


TGATTAGAGCCACCAGGTGAGCCTCTCAGCCAGTTGCTCCCATAGTGCCCTGTAGTTTCCCTTCAGGATCCTCATGGGTGGGTGGGT


GGGGGGCTGGCTGCTCAGAGGGCCATCAACACATTTTTGTTGAATGAATGAATGAATGAACAAATGATCCTTTGTAGTTTATTAAAC


CCTTTCAATCCATTGTCTCCTCTGCTCTCCAGTATGGCTCTGTAAGGGTACGGAGCAGGGAGAAAGAGAAACTGAGGCTCGGCAAGG


TAAGAGACTTGCCTCCTAGTGCTGCCTCCCCTGTCTGTGCCTCTCAGGGCCCATGAATTGCCTGGAATGTTCCCCTTGCTGCAGAAA


CATATCACAGGTAGATGCTAAAAGCAAGGCAAGCATCGCCCGCCCACACCACACCAGGCCTGGTACCATAGGTCCTCTCCTGGGTCC


TCAGTTCTTGCTGAACTGTAAGGAAGGCAGCAAAGTGGAGTGAGAAAGCTGCTTGGTGACTAACTTTGAAGCAGAGCAGAAGCTTCC


TTTGGCCCAGACCATCAAGGAGACAGTTGGGTGGACAGAATAAAGGGCTCCTCATTCCCTGATCTCCCTGTGCAAGGGAGGAAAGGA


AGGCTTCACTCGGCTTTCAGCCAGCCCCCGCAAATCCACGCTGATCCAGTCTCTCTGTTACGCTTTCTGTGCTGAGGGTGTATTTCC


AGGTTAAATAAAACCTCCACCCAACCCTGGCCCCAACATTAATTTCTCCTAACCCAGCCTAGTTTCTTCCGGCCTTGCAGCTCAGGC


CTTCCCAGGATGCATGCATCGCCTGCTCTCCCAGCCAGGAGGTGCTGATGCTGGTACCCTTCATCCTGAGCTCATGTTAGGCCACAG


GACCCTGCTAGCTCCTCCTTAAAGGCAATCATAACCAGCTTTGGAGAGCAGCAGCTCTCTGTGGCTGTTGGTGGAGCAGGCAGCATG


TGAGGCTGGAGTCTTGAGTGGGATGTGTTCGTGGATGAGCTGGGACAGGCAACAGCCAGATCTGCTGGAGGGCCAAGGACCCAGTAA


AGAGAGGGCATAGTGTGATGATAAACATTCCACTACCTCCCAGAAGTGAGGTGCCTGCACAGGAGGCCCACACCGAACATATGCCCG


GATCTCAGGCCTCACCCTCCAAGAATCAAATCATCGGAGCTGGATGAGACTTTAGAGGCTTCTCATTTCAGTCTCAGATGAAGACTG


AGGCCCCAGAGGGGAAGGATGTGAAGTCCCTTTCACAGTCATCAAATATGGTGGGACTCCACAGTGGGACTTACCGGAAGACAAAGG


CTGGACACACAGCAGGTGCTCAGTCAATTCTTGTGAGAACAGCCATCCTCATGAGGTGACAGCAGGAAGCATCTTCGTGAAAGTTTA


GGGCCAGAAGGAAGTTTAGACATCACTGAGCCCAACTGTCATTTTACAGAAAGACCGAGACCAGATCCATTAATAATGCTACAAATA


AGAATAGCTAATAGTTACATAGTGTGCTGGGTGCTAGGCAGGATTCCATGCATGTTGCATATACGAACCCACTGCAGCCTCACAGTG


ACCTCTATGCAGCAGTTATTATCATCATCCCCAGATGAGGTAACTGAGGCACAGGGTGGTTCGGTAATTTGCCCAGGATCATGGAGC


CAGTAGTGTTAGGATCAGGCAATCTGGCTCCAGAGTCCGTGCCGTGAACACTTCACTGCACTGTCTGAGAGCACAGTGCTGCCAGCA


AACACTTGCTGCCCCCTTCTCTGAGTGGGGAGAAGGAATCTGTGCCAGCCCTTGTGAGTTCACTCATGCAGGAAACATGACTTTTTC


ATCTTTACATCCCCTTACAGGGCTCAGCTCAGGTCTGGCAGGGGCTCAGGGATGTGTTTCTAATATAAATGAGTTGATCTTTCTCAC


CATCGTGAAACAGCCAATTTGGCACCTGTGTGCTGGAAGGGACCTTGGGAAGTGGCTCAACATAGAACACTTGTGGTCAGCAAAAAG


GAGGGGGTGGTTCCCACACACCAAGCAATTCTCCAATGGACACTGGCTGAGTGTCCTGCAATATAACTCAAGCCTGATTGTCCGCCT


GGAGTTAGTGTTGGCTCCCACAGGTTGAGGGCTCAGTCCCACCACATTTACCTGACTTCCGATGCTAGTCACCAGCCCCAGGTTGTT


TTATCTGAGCCTCTGACCAAGTGGCTATAAATCAGGGATTCCCAGGACGCCCTTCTCAGGTTTTCATTAATTTTCTAGAGCAGCTCA


CAGAACTCAGGGAAACACATTTACTGGTTTATTATAAAGGACCTTACAAAGGATTCAGATGAGCAGCCATATGGGAGCGAAGCAAAG


GGCAGGGCGCATGGGAAGGGGTGGAGCTTCCATGCCCTCTCTGGGCACGCAACACTCCACGTGTCCAGGGACCTCCATGTGTGCAGC


TATCTGGAAGCTCATCGAAACACAAAGAGGGGAACGACAGACACTGAGGGTGGAGAGTGGGAGGGAGAGGATCAGAAAAAATAACTA


TTGGGTACTGTACCCAATAGTACCTGGGTGACGAAATCATCTGCACAACAAATCTCTGTAACACGAGTTTACCTATATAGCAAACTT


GCACATGTACCCCTGAACCTAAAATAAAAGTTAAAAAAACAAAACAAAACACTGTCTTTTTGGGATTTTGTGGAGGTTTCATTACAC


CGACATAATTGATGACATCATTGGCCATTGGTGATCAACTCAACCTTCGGGCCCCTCTTCCTTCTCAGGAGGTGGTGGGGTGGGGCT


GAAAGTTCCAACCCTCTCATCACCAGATTGGTTCCCCTGGCAACCAGCGCCATCCTGAGGCCACCCTGGATCCCCACCCCGACCGAC


CCCAGCCACTAGTCATCTCATTAGCATACAAATGACACTTATCACTTTGGAAATTCCGAGCGTTTTGGGAACTGTGCCTAAACCAGG


ATAAAGACCAAGTACATTATTTCTTATTATAAATCACTATATCTCAGGCAGCGATTTGCAGAGGAGGAAAGTGAGGCCAAGAGAGTC


AAAGTGTCTTAGCCAGGGCTTCCCAGGTAGACTGAATCCAGCTCTCCCTACTCCACATACAGGGCTCTTGCCACATAGCAAGGCCCC


TAAAGAGCATGCTGAGGTGGTCAGGCTGACCTGAGCCCAGCAGCCTGCCCCAGCCTGCCCCACCTGTCCTGCCTGGACCCTGCTGTG


GGCTTCCTGGTCCTGGCCACACTAATGGACTTTCTGCTCCCACCAGCTCTTCGTGATCGACAACGGCGCGCATGACTGGCGGATAGC


CATGACCTACGAGCGCATCCTCTACATCAGCCTGGAGATGCTGGTGTGCGCCATCCACCCCATTCCTGGCGAGTACAAGTTCTTCTG


GACGGCACGCCTGGCCTTCTCCTACACACCCTCCCGGGCGGAGGCCGATGTGGACATCATCCTGTCTATCCCCATGTTCCTGCGCCT


GTACCTGATCGCCCGAGTCATGCTGCTGCACAGCAAGCTCTTCACCGATGCCTCGTCCCGCAGCATCGGGGCCCTCAACAAGATCAA


CTTCAACACCCGCTTTGTCATGAAGACGCTCATGACCATCTGCCCTGGCACTGTGCTGCTCGTGTTCAGCATCTCTCTGTGGATCAT


TGCTGCCTGGACCGTCCGTGTCTGTGAAACGTATTCCACATGGGGCTTTCTGAGTACAGAGCCTGTGCTGGGACAGGGAAGGGAGGA


GGAGTAGGGGTGCCAGGAAGTATGTGGTCTGATGGAGGAGACAGGCATGTACCCAGACACCTGAAAGGAGACAATGGGAAAGAGGGG


AGTGCTGAGTTGGGGTTCAGTATGAGCTAGAATTGCAGCATTGGAACCAAAGTAAGGTGGGAAAAAGGCACAGAATTTTCCTGATTT


TCTGTTCCTTCTTTGCAAACCAATATATCAAAGCATTCTGGTTACATCAGTAACTCACATATAACACATTGCAACTTACTCCTCTTG


GGTATTAATAATGCTTATTAGCATTTTAAAGGCTCTGAGAAGTCCTGAAGTAATGAAACCATTTATTTTTGTTTGGTTCAGCCTTTC


TTAATTGTATTTGCCTGCAAATCCTTTTTATTATAAAGCACTATTGGTACCTTGCTACTCAAAGTTTGGTTCACAGACCAGCAGCAC


TGGCATCACTGGGAACTTGTTAGAGTTCCCAGAATCTCAGGCCTTAGCCCAGAATGAATGAATCAGAATTTGCATTTAACAAGGTCA


CCTGGTGATTCATATGCACCTTAGTTTGAGAAGCACTGTACTGATGGAACATACTTTGGGAAACATTGTTTTAGGAGGCTGGTGGTT


GGGAGTCATTCAGAGAAGCTACTCATGGGAAAGAAGGGAGATGTGGCCTGACACAGATCCAGGGCTGTAGAACAAAATGCCAACTCC


TTGGAACAGCCATCAACAAGGCTCAAGGGCAGGACTGAAGCCACCTCCTTCCACCACCCTCGAGCTGCCTTTAATGACTCTTCTCCT


TGCAAGGGGTCCTGGATTTTCATTTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATCTGAGATGGAGTCTC


GCTCTCTCGCCCAGGCTGGAGTGCAGTGGCATAGTCTCTGCTCACTGCAACCTCTGCCTCCTGTGTTCAAGCAATTCTCCTGCCTCA


GCCTCCCATGTAGCTGAGATTACAGGCATGCGCCACCATACCAGGCTAATTTTTGTGTTTTTAGTAGAGATGGGGTTTCACCATGTT


GGCCAGGCTGGTCTTGAACTCCTGGCTTCAAGTGATCCTCCTACCTTGGCCTCCCAAAATTCTGGGATTACAGGCGTGAGCCAGCTG


CACCCAGCCCTGGATATTCATTTTAATCTATTTGACATGTGGAGTCTAAATCTAGGTTAGAAACCGTGATTCTGCTCCTAAGTAGCT


GTGAGACCTAGGGCAAGTTACTTAACCTCTCTGGGCTACAGTTTCCTCATTTTAAAATGAGGATCACTTGAGATAGAATGAAGCTAT


GTTTGCTTGAGATAGATTATTTTTATTATGTTGGGAGGTATGGTGAAGCATCCTGTGTAATTTACACAAATCCTGGTAGTCGCCCTT


AATTTGTCAACACTTACGATTATATTGCCAAATCTTCCATGCACCAGTGTCCTAGCAGAGATCAAACAAGACAAAGAAGTCTGGAGA


GGAGTTAGCCTCAACACACCCTACATGGGTGCCTTGAATCGTATCTCCTACCTATTTTTGAGACATTCTGTTTGCAGACATTTCTTT


CAGCGTTTTGGCCAACAGACACACGGTCAAACTGAGAGGGCATTCTGCTGCCGCAGAACAAGGGTTCAGGCTCCAGGATGCAGGTTC


AGGTTCTGAGAGCCAGTGCAGTGTTGGAAGACCTTTCTCACACACAGAGCCCCAGGGACACACCATGCTCACCTATTCAGAACCTCG


CCATTACTCAGCAGCTGACATTGCAACATCTGCTCTGAGTGGGACCACACTGCACAGGGCTTCATGAGCCTTCTCTGGTAAGCAGAC


ACTCTTCCCCCAATGGAGAAAGCATGTGCTTGGGTTCCGACCCCAAACTCTTCATGGTACTGTTAGCTGAGCAACATTGTGCTGGTC


GCTTCACCTCTCTGGACCTCAATTTTCTTATCTGAAAGCTGGACACAGGATTTATTGTTAGAGTCAAACAAGGTGTATATATGCACT


ATGTACTGCAATCCAATGATGGTGAAAGTTAATAATAATAGTGCAGATCCCTTGATAACTCTTGGGAATTTTGTGCTGCCTTCTTTT


AATTAGAACAGCCCAACTTGTACCATACATGGGCCTATACTCTTCCTGTTTTCCTTTCTAAATGATGGAAGCCATGTTGTCTATTAA


CATAGTAATTGAATTTGCGTAGCCCTTTAAGCTATTTGAAGTCTTTCACTTCCTCAGATGCTCTCTGGCATGTATTTCAGATGGCTG


AACATGCAACAAAGTACCTGCAAGTGAGTTTCGTAGTTTATTGAACCTATCACAAGAAGGGGTGACTATTTTTCACTGGAAAATAAG


CTTGTTTTAAAGAATGTAGTTTGCAAAGTACTTAGATGATGCACCTTATTTGATATTGCATGGCCTTCCATAGCTTCCAAGCTGAGG


CTGGGTTAGTTTGGTCCCTGGTGGGCCACTGGGTCTCTCTCTCTCTCTCTGCAGACATGGGTCACAAGCCCCCGCTAAGACCAAGGC


ACAGAGGAACAATGAGCAAATCGGAAATTCTCTGAAAGTTCCCTTCTCTTGCGAAAAGGCCATTTGACCAAAGACTTAGGTATAACA


TGAGGTGTATTAAAGCATGGTGGATGTTATTGTTGCACCCCTGTCCTAGTTCTGTGTAAAATCCATATGTCATCCCAGCTTGCCCTC


ACAATAGATCTATGAGAGAGGTACCTTGCCTGAGGGAAGGAGAGCCCGGGTCCTGGAGGGGCATTTGGGTGAAGCAACATGTCATCC


ACTACATGGATGTGTTTGAATTGGACATGAAGGCTCATGGGAGAGTTGAGGAAACTCATAGAAAGTAACTGGCCCGAGGTCACAGAG


CTATTAATAATAAGCGTGGAGCCAAAATCTGAACTGGTTTCTGACTCTGAACTTCCATGTGTGTGTCACCAACCCAGGCTGAATCCT


GCACATACGAGGAAATCTTGGCCTCTACTCTACTGGCAACTTTCCCAATCTCAGAGTCTTAAGGCCACTGAGACTAACATGTGAATC


CCAGTCTTGCTGTTTTCTCTGCCTCTGCTGCCTATGGTCTTGACCATGTTATCATACTAGCCTCCTGGGCTGCCTTCATGTCCAATT


CAAACACATCCATGTAGTGGATGACATGTTGCTTCATGTCAACATGAAGGGGACAGATGCCCCCTCCAGGACCCGGGCTCTCCTTCC


CTTAGCTGGGGTTGTGACTGAGTCCCTCTCTTCAGGTCAAACCCCTTGCCTGGGGGCAGCAAGCTCCCGAGGGGATTTGTCAGTGTG


GGAGTTCAAAGGCCTAACCCCGTTTGCTTCTAGTAGGACACTCAGCCAGGCTCCAGGGTCCCTGAGGGATCGCCTAAGGCCTCTGTT


ACCACTGCATCCGGGAACTTCCTCTATACCCCAGAGGTATTGATCCTGAGAGCAGCCCCAGTAAAACTCCCACCCCCAAATCTCAGC


ATCTCACAGACTGTTTCCCAGGAATCTGCCCCGTTAATATATTGTTTCCTAAACAGGCAAAGCACTTCTCTTACCAAGACTAAGCAC


TATTTTTAGAATCAAGCTTAAATGATCATTCTGTTTCCCAATGTCAAATAATAAGTAAGATTGGCAGAGGCCTTCAGCCAGGACTTA


TTCAGCCAGAGACTGGACAGAAGCTGGAAGCAGGGGAAGCTTTGGGGAACTGAAGCGTCAGACCAGGGTAGTGTGGACAGGATGCCT


TGATCTCTCTCAGCCTGATCTAATGATGATTCTATCACCTTAGGCATCAGAGAGGGTAAGTGACTTGCCCAGGGTCACACAGCAGCA


TGACAGGTTCTAGAAAAATCCACAGCTGCTGATGCCCAGAGCCTGTTCACATTCCAGGTAGCTTTCATCAGCCTGGACTTATCTCTA


GTTGTATACACACACTTCTGAAGTTGCTATGGAAATCTCTCTACAGCAAGATGTATTTTAAAAGACAGTTCTCATATCTTGGGTTGG


TTTTTATGTGACAACAAAGGTTTTTCATATTTCCTCCTCCCAAGGAGAGAAAGTGGGATCATAATTACGCAGAACAGCCGTGCCATG


GGGAGGGCAGCGCCTGGTTGCTGGGAGGGCAGTGACAACAGTGGGCTTGTTTTCCTTGGCCCCCAGAGAGGCATTACATCATGGGTT


CCGAGGCCTGACAGTTGTGGCACTCTGCATTCTCTGGGATTCTCCTGGCTGCCTGCCCACCTCCCTCAGGGAGGAACCTCCTGATTT


TACACTGTCAAGTGCCAAGCAGCTTTACTGGTGGAGAGACCATCTGAGGCCCCGGGTCCTCACTGCGGCAGCAGGTTGGAGAGCCAG


CCTTCCTAGCGTGCCTTGAGCAGTGCAGTGGCCTGCCAGCTCACCTTTGTATGTTTATCTCCTTGGGAGGAGCAACAAGGCCTCCCA


TAACATTGATGAAGTGGGGTGAGCCTTGCTGTCACAGCCATGCTTTATAAATGACCTTACTGTCCTCTTGAGTGGATTCCCTTCGGA


CCCTTTGGACCCTTCACTTTGGTCCCTCCTGAGGCTCCAAATTCTGCAACAGGCTGTCTCAGTGTCCCAGGCCTTCCAGTCTGTCAA


CAGGTTTTTTATTTTGCTGGTTAACTTTTGGCATACTGATATTTTAATGAGAAATTTTATTCTGGAGATCTGGCTCCTAAAGCAGGA


GAAAAACAATTTGTGGCCCATTCTTTCTCTCATTAAGAGAGCCACCACTCCCATTGTAAGGAGATAAAAAGAGGCTTCCTTGCTGTA


CTCTCTTCTGCCCCTGCCTCAGACACCCAGGCCTGCACTTGCCAGCAGCAGGAAGCAAGACCACAGCTCCCTCCTCCTCCCATCTCC


TTCCCACAACCTCCTACCCCCTCCAAGAAGGGGTACTTCCACTCCAAGAAAACAGTAGGAATGGCCAGGCTCGGTGGCTCACGCCTG


TAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCCGT


CTCTACTAAAAATACAAAAAAATTAGCCGGGCATGGTGGCACACACCTGTAGTCCCAGCTACTCGGGAGGCTGGGACAGGAGAATGG


CGTGAACCCAGGAGGCGGAGCTTGCAGTGAGCCGAGATCACGCCACTGCACTCCAGCCTGGGTGACAGAGCCAGACTCCATCTCAAA


AAAAAAAAAACAAACCCCAAAACAAAACAGTAGGAAAGTGGTCATTACAGGGATGAAGCACCCTACATGGGGTTGATGGAAGCCTGC


AAGCTAAACCCTGTAGGCTGAGCAGAACTGAGCAGAGCCTGGGAACAGTGGGGCCAGGCACTGTGGTTCCTCATGGACTGCTTTGGT


TTGAGTTATAACCTCCAATGTGGGGCACACGCACAGTGATCCATGGGACTATTGGGACAAATGATCAGAACTTCTACATATATATAT


ATATATATATATATATATAAAGCCTGGCTAGTATTTAATAAATGCATAGAGAGCAATACATGTCTGTAATTTATAATAAATATATGT


ATAATGGAGGAGGGCATGCTCAAAAAATTTTTAATTGGTAGGAGCCCATGATTTTAAAAGTTTGCAAACCACTGGTTTATGATATCA


GAGGACTAGTTAGAGAGGATAGGAAAGTAGCCTACCACATGGGATGAAGCCTGCTAGACCCAGGAACCCTGCCCTCTAGCTGGAGAA


GTGAGAAGTTAGCCTCCTGTAGGGAAGGAGCAGCCTGTAGCGATCCCCTTCTGGTGCCAGGCGGAGAGATAGATGGCTGGGGAGGGG


GAAGGTGGGGAGGCGACAGGGATCCTGCTGGAGGCCTTTGAGAAAAACCTGCAGCATTAAGGAAGAGGAAAATAATCCTGAAGATTC


CTGAAAAATGTTTAATTATGAAAAACAAAAAGCAACATTAGAAGAGTCTTGGGTGGCCAGGCACAGTGGCTCACGCCTGTAATCCCA


ACACTTTGGGAGGTCAAAGCAGGTGGATCGCTTGAGGTCAGGAGTTGGAGACCAGCCTGACCAACACAGCAAAAACCCATCTCTGCC


AAAAACAAAACAAAACAAAACAAAAAAAAACCAAAAAAAACATTAGCCGGGAGTGGTGGTGCATCTGTAGACTCAGGAGGCTGAGGT


GGGGGGATCACCTAACCTGGGAGGTCAAGAGTGCAGCGAGCAGAGATTGCGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACCC


TGTCTCAAAAAAAAAAAAAAAAAAGGAAAAAGAAAGAAGAGTCTTGGGCATCTCTAATAGGGTGCCAGAATATATATGATCCTTATG


ATAGACAAGAGTGGGCAGATGTGAAATGAAAATGTATCTCGTTCACATAAGCACAGAGTTCCAGAAAACTAAAATTGTTTTAGCAAA


ATGAAAATCCACATTGATGGCACTACATTTTTAAAAATGTGGAATGTGGAGACAAACTTAAAAAATTTAAAGCTCTCTCAGAATGCA


GAAGAGATAAGAGAAAGGATGAATAGGACAGAACTGGAGGCTATAGGATCCAGGTGAAATCTAAGAATTAGAGTTATTTCAGAGGAA


GAAATGATAATAATTTGGATAAAAGCATAATCAGAAATATACGCACAGTAAACATTTTCAGAATTGGCCTAGGTAAGGGGATGTTGT


GTGTGGGGATGGTAGATCAGAGTAGGCAGATCGAAACGGATTCCTCTTTTCCAGTTAGAATGTGGGGGACAGGAGGAGCCACCCCTA


GACATACCCCAATACATTCTTTTTCTGGAAAATTTATTGAATCATAAGGTGAAACAATCCTAGAGGCACACAGGCATCCCAGAGCTG


ACTCTCCCTCAGGAACCCTAAATTCAGAGTCATTAGAACAGTTCCACAGTATTTTAAATTTGGATCCACCCTGTCATTTGAATGAGG


CAACCAAAGGGGAACAAAAGTCATTCTTGGAGTTTACTTTTGGGGGGAACTCGTTTGCCACTTGACCAAAGACTGAATCACAATTAA


GATCTTAATAATGAAATGTTGTAAAGAAAGGCAGACATTGGTTCACACAGGCAAACATGAAATCAAGACTAAACTTACGCGTAGTTG


CAAAACTCCAAATTCTAATGTCAAAGAAAAAGTAGATTCTGGAAAGAGTGGATGTATGAAATTAAAGCAATAATTCAATAATAATTA


GACGGTTGCAAATCCTCAGATTAAAAATTTGAGAGGAGAAGGCTAGAAGGGATTAGTAAAAGCATGCCAGATGCGTTGTCCTATGTA


GAGGAGAATTTTAAAATAAAGCCCTATTACTCAGTTTTAGCAATCAGAGAAATATTTTTTTTAAAACCTAAAGGAACCACAGGCAAA


ATTTTATGAGTATAACAAGAATAACAGTAGCATCAGCCATATATTGTTTCACTTAATCCATACCATAGTTCTATGAGACTGTATCTG


CATTCTGTATATGAGGATGTTGAGACACAGAGAGGTTGAGCGATGTGCCTCAGGCCACAGAGCCAGCAGACTTGAGACTCCAACACC


AGCCTGAGAGCCTTTTCCCTACCCTGAAAACATATACCTCCCATGCCACATCAGAGCCCACATAGCTAAGACAGAAAAAATAAAGGA


AGCAGGAAGGAAGAATTTCAATACAAAGTATGAAAGAAGATCAGAGAAAAACAAACTTAAAATTTATAACAATCAACATAATTGTGT


TTACCTCCTTGTTAAAAGTAAATGTCTCTTAGATGAGATTTAAAAGCAAAATTTAATTGCATGCAATTTACAAAAGAAGTACCTAGA


ACAGAAGGACCCAAAAATAAATGAAGAGCAAAGATTTATTAGGTAAGTACAAATCAGATGGCAAACGAATAGAAATTCTCATTTTAA


ACCAAAATGAATTCAAAACAGAAATCATTAAATTGTCCAAAAGAACCATTTAATATGGATAAAAGTGCTATATACAGTAAAACTGTG


AATTTTATACAAAAAATGAGATTGATAATCTGAATTTTTAAATGTTTAAATTAATTGAGCACTTTGTAGCCTATAAACAAACATCTT


CTTTTTAAGCATCCAGGGAACACTTTAAAAAATTGATCAACTTCTTGGTCACACATTTCAAAACATCAGAAAAGTTGCTCGGGCTGT


ATTCTCTGACCACAAGCCTATAAAACTCCAATTAAAGGACAACTTTTTGGTGGGACTTTTAAAGCAATCTCCTCAATTACAACAGAG


AATTCAAAACTACCGTTAAAGGCTATTAGAAAATTACAACAATGATGACCCTGTACGTAAAAACTCAGGATGTGACCAAAGGTGTAC


TCAGATGAAAAACATCCTTAAAGTTTTTCAGGCACAATGGTGTGCACTGATAGCCCCAGCTACTTGGGAGGCTGAGGTGGGAGGATC


ACTTGAGCCTAGGAGTTCGAGCCAGTAGTGGACTATGATTGTGCCTGTGGATAGCCACTGCCTCAGCCTGGGCAACATAGGGAGACC


CCATTTTTAATAACAAAAACAGAAAAAAATGAACAGAGAAAATAACTGAATCCATTAGAAGAACAAAACAAACCTCAGGAGGGAAGA


TTAAGTTTATAACAAAGGCAAAGATAGGAATTAATGAATTTAAAAACCAGAAAAACATAATTTATAAATCCAAAAGATACCAACTTC


TAAAATATAAATTTAATTGGAGAAAAAGAAACACAAAATTAGAAATTTTAATGGAGAATAACTACTGATTCTTAGGATGTTTTAATA


AATAAGTGAGAATAGCTTAACTTTTTTTGAAAGAGAAGACCATTGAGGGGCTTTCTCTACTAGATATTAAAATGTATTATAAAACTG


AAAGTAATTAAGTCCCTCTGGCATTACTGAAAAATCAATAATGACAGATCAATGAAACCTAATGGAAAACACTGAAATAAACCCTAC


TATGTTAGAACCCAATATACGAGAAAGAAAACCAACTGGGAAGCGATAGATTATTCAATAAATGGTAATGGAGAAATTGGAAGCTTG


GATGAAAAATCAAATTGGAACCCTAGCTCTCACCAGCCACCAAAATAAATTCCAGGTGGATTAAAAAGTCAGATGTAAAAGAAGAAA


CCATGAGCAAGCTCCAGAAAACAAAGTGAATATTTAATCAGCCCTGAGAGGAGAAAGAACTGTTAAGCATAAAATCTCAGAAGAAAC


ATGAAGGAAAAAACTGGTGTGTTTGATTACATCATACACACAATTTTAGATTTCAGTCCCTCAAAAAATATGAACTTATTTAAAGAG


CAAATGTTATGCTAGAAAAAGTATTTGCAGCAAACATGACAAGAGGTAAATATCCCTATTATACAAAGCAGTCTTAGAAACTAATCA


GAAGAACTTATCTCCCCAGTCAAAAAAATAGGCTGAAGATAAGGCCAACTACAAAGGAAGAAATACAAAAAGCCAATAAAATAAAAC


ACACAACACATATTCAGTCCCTCTAATCAAAGAACTGCAAATTATAACTACAAGGAGAATTACTTTTTCCCCTCTGGAGTTGACAAA


ATTTTAAATAAATATAACTCAGTGCTGGAGAATCTTCTTATTGTTGGCGGTGGGCGGGCATGGGGTTGTCTTACGCTGAGGGCAAGA


AGGAAATTAGACCATCTTTCTGGAAAACAATTTAACAATTTGTCACAGGAGCCTTGAGTTTGTAACTTTGATCCAGGAATTCTCTTT


CTAGGAAGCTATTTTAATAGAATAATCAATTTACATCAAACCTCTTCTGCATGGTGCAGTTTATAATAGAAAAGAATGAGAAACCAA


GTAAACATCTAGGATTTCAATGGCTAAACAAGTATGGCACATCCATATGATGGGTAGTTAGCAAGAATTTTAAAAAATCAAATCAAC


GTGTTTGTTTTCGTTTTTGTTTGTTTGTTTGTTTGTTTGTTACTTCGTTGTTTGTTTTTGATGCGGAGTCTCATTCTGTCGCCCGGG


CTGGAGTGCAGTGGCGCCATCTCGGCTCACTGCAGCCACCACCTCCCGGGTTCAAGCAATTATCTTGCCTCAGCCTCCCGAGTAGCT


GAAATTACAGGCACCTGCCACAACGCCTGGCTAAGTTTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATATTGGCCAGGCTGGTCT


TGAACTCCTGGCCTCAAGTGATCCACCTGCCTCGGCCTCTCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCTAAAAA


TCAATCTTTTGAAAATTACAGTAAGGTAGGAAAATATTCATGATGTAATATTTGAAAAAGGAGCGTACAAAATAGCATTATGTAGGA


TATTACCGATTTATAGATAGGTGCAGAAATACCTGGAAAATACATAGAAACATTAAGTTGATTTCTTTGTGTTACATGTAATATTTA


TTTATTTATGAGATAGAGTCTCGCTCTGTCATCCGGGCTGTAGTGCAGTGGCGCAATCTTGGCTCACTGCAACCTCTGCCTCCTGGG


TTCAAACTATTCTCATGCCTCACCCTCCTGAGTAGCTGGGATTACAGGCGTGCGCCACCATGCCCGGCTAATTTTTGTATTTTTAGT


AGAGATGGGTTTTCGCCATGTTGGCCTGGCTGGTGGTCTGCAGCTCCTGGTCTCAGGTGATCCGCCCGCCTCAGCTTCCCAAGGTGT


ACATGTGATTTTCATACATGTAAACATTAAGTTGATTTCTTATGACGTTACATGTGATTTTTTATTACTTTTTATTGTATTTTCAAC


AATGAGAATGAATATACATATATAAATTTTTAATGGAAAGAGGTAGCATTTGTTTTTACACACTTGACGAAGCCCCTCATCTTCCAT


AGGAACTCATGTTTTACATCAACGCGGGGTGGAAAGTAAAGCTGAATGGCTCAGTTTTTACACATAATTTTCTCTAACAAGCGCAAT


GCAAGTTCCGTCTTGAAGGGCTCTCTTCCGACCCGTCGGCCAGTGGCCTTGGTGGACAGGGCCGCGGGGCGCCTTTGCGGGGCCGGA


GTGCTTCTTCGCGGGCGCGCGCCTCCCTTGGAGCCCCTCTGCGGCCGGCCGCTTATGGGAGCGCCCGAGCCGGCGTGCGGGCAGGTG


GAGCTCCACAGGGGACGTGTGATCGAGGCAGGCTCCACTGGCTCTTCAGTAGCCTCCCGGGCGTCCCCGCGGTGTTGCGGGGTCCGG


TGGGGAGAGGCCGCGAGTCCGCGGGTGGTTCCCGCGCGGCCAGGCGGTCGTGGAGAGGCCGGGGCCCGGGAGAGGCCGAGGCTCGCT


CCGCCAGGGGGCGCAGGGAGGGCCAGGTGGGCGGTGTCCCCACCTGCAGGGACTCGCTGTGGAGGAGCAGAGCGTTCAGGTTTCCTC


TCGCTGTGGCGACAGCCGGAGCGGCTTCAGGGCTGGGCCGGCGGCTCCAGGGCTGCTGCTAGCTCCTGGCTCCTGTCTCGAGTGGGA


TCCCATTCTGATTTCACCTGCGTGATTCACAGTCTCCAGTCCCACTCCGCGGCCGCTTTCTCGTTCTGTGATCTCGTATTCAGCCGT


TCTTTCCTCTTCCTCATTGGCAGTATTTTTGTGCCCTTTGACACTTAAACTGCTCATTCGTGGCTAGTTTTTTTCGTACTTTTATAT


TAAATAATTATACATGACTTAGCTATTATAAGTAATGGCTGATATCTCTTAGAAAGGAGAATCAAGAAATAGGGAAATTATTAGCCA


GCGTGGTGGCGCGCACCTGTAATCCCAGCTACTCGGGAGACTGAGGCAGGAGAATCGCTTGAACCTGAGAGGCGGAGGTTGCAGTGA


GCCAAGATCGCACCATTGCACTCCAGCTTGGGAGACAAGAGTGAGACTCCGTCTCAAAAAGAAAGAAAGAAGGAAAAGAAAGAGAGG


AGAAAGAAAGTGGGAGAGAGAGAGAAAATAAAATAAAAAAGAAACTGGTAAAGCAAGGAAAATTTCCATAAAATTTGCATTCTGAAG


CACTAAGTTTGGGACTGTGGGTGCAAAGTGAAATCCATATTGCATTGAGAAACCATTCCATTTTTTCAGTCAAGTCAACCCCCAAAT


TATTCCAAATTATTTGCTGCATTACACCAAACCTGGGTTTCCCTTCACTCTCTTCTGCTGGGAAGTCACCAGTGTCTTTTGTCTCCA


GGATTTTTGCCTTAGGGAGACCCAGTTAAATGCCAGGGTTCCTTCTTTAACTGGGGAGGACTATCTGACCTTTGTCACTGGAATGAA


TTCCTTCCCAAGTCTGCCAAAGATGGTACACAGTGACAGTTAGTGCCATGCTGGGTGTGTAGGAGAGAAGTGACTTCCTTTCCTACA


GCGGATGCCTAAGGGCATGGGGCTTCATTCTCACCCGCTCCCCCACCCACCTCCTTGGAGGGGCTGAGGTAAGGAAAAGGAAGGGGT


TCCTGTAAGTGACGTCAGCCACATCTATTTGTGGGCTGACATTAGTCAAGCAGGAAATCCATATTCTGTCAGCTTTTCCATCCTTCA


ACTTTGGGGTTGTTTTGTTTGCCCCTCGTGATCCCATTGTGCCCTACATTTCCGGTGCAGACCCCTCCCTCAAAGGACGGGCACCTC


AGCTCCACAGGGCCCCTTCTCCATGAGTTTGGTGTCCTAGGCTGGCTCTCAGGAGCGCAGCTCTTCACCCCCCTGTGTTTCCCCTGC


CCTCCACTGCCAGCTTGGGGCCCCCGCGCCAGGCTGGGGTAAAGCCCTGCATTCCTGGCTCACATAGCGCAGCTGCTAGAAGGGTTT


TTAAAAATGTGATTTTTTTTGGCCGGGCATGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCAGATCACCTG


AGGTCAGGAGTTCCATACCACCCTGGCCAACATGGCGAAACGCTGTCTCTATTAAAAATACAAAAATTAGCCCAGTGTGGTGGTGAG


CGCCTGTAATCCCAGCTACTCACGAGGCCGAGGCAAGAGAATCGCTTGAACTCAGGAGGTGGAGGATGCAGTGAGCCGAGATCACAC


CATTGCACTCCAGCCTGGGCAACAGAGCAAGACTCCATCTCAAAAACAAAAACAAAAACAAAAACAAAAACAAAACGATGTTCTCCT


TCCATTTAATACAGACTCCTCTGTTCCCTGAGACTTGGCCCCAGTCCCCCAGAGGCTGAGCTGAGAGGGAATATGGGTGAGACATGC


CATATTCCTTGAGTACCCCACCTCGTTCCATTCGGTCTGGATGCCTGCTTGCCCCCCACTGCACAGAGAGTTTAAGGGCAGCCAAAG


TCCCCTGGCTGCCTTTGAGTAGTGGCCCTGGAAGCCTGCTGGCCCTAACACACCTGGTCATTTTGTTTTCCCAAAAGGCGCCTGGGA


GCCGCCTGGTAACACAGCCCCTGCGGGCCCTCTCAGACAGGGCCAGACATGCTGCAACGGCCCCAGATGGGCTCTGACACTCCCACA


ATAGAGGGGGCACAGAACTTAGTAAAACTCCTTTTAAATATCTTAAACATGTTTCAGCTGAGCCAAGGGGAAAACACCTAGTACACA


GTGGCAATCGCACCAGCACAGGATCCATCCTGTGATCAGGACTGCCTGAACTCAGGGTGGAAAAACTCGGTTTGACCCCTGGTTCTA


CCATTAACCTTGCACTTGTACTTAACCTGACCAGAGTCATGCAGCCTCTTTTGAACACCCTCTGGGACACTACTTTAAAAGACTATC


CAATCCATTTGCAGACAGCTCTGACTTAGAAATCTCTTCCTATTATTGGTTAATATTGGTTAAAACGTGTAGTTTCTGTCTTGGGTC


CTAACTCAGTTCTCTGGGTCCGCACGAAAGAAGTTCAAGTACCATAGGCTGGCGGTTAAGCCATTGACCTCTGGGAAGATGTGAGCG


TGGAGCCTTGCTTATGCTCTTACTAGCAGGTGACGTTGGGCCAGGAAAGGGGATAATTCACAAAAAGCCCTTAGCACAGTGTAGAAC


ATTTAGCACACGGTGAGTACCCAGTGAAGCAGCCAGGTATTTCTTTTTCTACTGAAGGTCCCTTGAGTATCCAAAGTCAGGTTGAAT


CTTCTCTGCTCCAACCCAGTGGTCTCCAGTCCCCTCAACCATTGTCACAGGACTTCTGGTCAGACTCCACCCTCTCGCTCACTCTCC


TCCCCTGGTCATCAGTGTCCTCATGAAGCGAAGGCCCCAGAACGAACATAGTGCCCCAAGTGTTAGGCATCCTCCCATTTCCTCGGC


ATTATTTTCCTTTTAATGCAGCCTGAGAGTGGCCCATATTCTTAGGGCAAAGGGCTCCCAGGCATAATGGCCTGGGAATTAGGGAGC


GAGACCCAGGGCCCATCTCTGTTTAGATTGGGCACTCTTGACAGTTCCATTCTATAGCCCCATGCTCTATTGTTAACTTTTCTTCAA


TACAATTGTAAGGGCCTTGTTTAGCCTGAATCCTGCAGGGAGCAACTTGCACCCTTGTTCCACATGGCCACTACCAGATAAGAGCCA


CAGCTCAGTAAGGCCAGAGGAGTGGTTCAGCCACGTGGGAACCAGCCAGGACTCAAAGAGACAAGAGGCTCCTGTCCTGTTTCCAGC


TTTAGCAAGGGAGTTGAGGGCTGGCCTGAAGTCCATTTCTCTCTGCCTTAGTTTTCCTGCTGATAAAAGCAATAGTTAGTTTCTCAG


GCTCCCGCAGATTTCTCAACAGATTGTTTGAGCACTGAAGTTGAGATCTCTCCTGCTCTCTGGACACATCTCATACTGATTCCCCCC


ATACCCTATTTCCTACACAGGTCTGTCCTTTACCTGGACATTCTCCCTCCTCTGCCGTTTCCCTTCATCATGCTTGCTCCCGGAGAA


TGCAGGCACTCTCACAGGAATGCATCCATGCATCCCAAGTGGAGCATTGAGCCACGCCTCTCTCTGAGCTGCAGTGCTCTCATGAGA


GACTTGCTAAATAATAATACTGTTATGTATAGGTATGGAGCTCTGCTATTCACCAGGCACTGTGCTAGGAATTAAATATATCTTAAA


GCATAAAACACACATGATTTTTTCCCTCATGGGCTTACAGTCTACCAGGGAAGACAGGTAACAAGTAAGGAAACAAAAAGTAGATAA


TTTCAAATCTATGACATATACTGTGAAAGTGGAAAAAAGAAGTTTGCAATGATTCTTTTTTAAAAAAAAATTTATGGCATTGGATTG


GGATCCTACTCATCTGGGGCCTGCTTGGAGGTGTCTCTGGGGAGGTGATGCTTCAGCTGAGGTCTGAAGGATGAGAGGAAATGAGCC


CTTCACAGACCAAGAGGGTGAGCCTTCTGAGAAGAATGAGAAGACTGCACCAAGGCCCTGAGCTGGCAAGGAGCCGCGGGGAAGGAG


TCACTGGAAGGAGAGTAAACAGATGAAGGGGGGTGTGGCAGGGACTGAGCCGCAGAAGGGGGCAGGAGGCTGAAAGTGAAGGGCCCT


GAGTGCCATGTTGTGGGGTTGAACCTAAGTGCAGTGGAAAGCCTTTAAAGAGTTTTATCTTTTTATTTACTTGTTGTTTCTTCTTCT


TCCTCCTCCTCTTCTTCTTTTTCTTCTTCTTCCTCTTCCTCTTCCTCCTCCTCCTCCTTTTCATCGTCGTCGTCTTCTTCTTCTTTG


CCTTTGCCTTCTTGTTCTTCTTGCTCTTCCTCCTCCTCTACCTCCCCAACCCCTCCTCCTCCCCTCCCCATCCTCCACCTCTTCTTC


TCTTCTTCTTCTCCTCCTTCTTCTTCCTCCTCTTCCTCCTCCTCATCTTCCTCTTCCTTCTTCTTCCTTCTTCCTTCTTTCCCCCTC


CTCCTCCTCCTTCTTCTTCCTCTTCCTCTTCCTCCTCCTCCTCCTTTTCATCATCGTCTTCTTCTTCTTTGCCTTTGGCTTCTTGTT


CTTCTTGCTCTTCCTCCTCCTCCACCTCCCCAACCCCTCCTCCTCCTCCCCTCCCCATCCTCCACCTCTTCTTCTTCTCTTCTTCTT


CTCCTCCTTCTTCTTCCTCCTCTTCCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNCCCTTCTTTCTTTCTTTCTCTCTCTCTCTTTCTTTCTTTCTTCCTTCCTTCCTTTCCT


TTCTTCTTCTTTCTTTCTTTCTTTCTTTCTTCCTTTCTTTCTCCCTTTCTTCCTTCCTTTCTTCCTTTCTTTCTTGTCTCACTTTGT


CACCCAGACTGGAATGCAATAGCATGATGACAGCTCACTGCAGGCTTTAACTCCTGGGCTCAAGCAATCTTCCCACTTCAGCCCTCT


GAGTAGCTGGGACTACAGGCATAAGCCACCATGCCTGGCTAAATACAAAAATTTTTTGGCGACAGAGTCTCTCTATGTTGCCCAGGC


TGGTCTTAAACTCCCAGCCTCAAGCAATACTCCCACTTCAGGTTCCCAAGTATTAGGATTATAGGTGTGAGCCACCATGCCTGGTGC


TTTTGAAGGGTTTTAAATAGGAGAGTAATACAATATGGTTGCTTCTAAAAATATTACTTTGGCATCTTTGTGAGTAAATTGGAGGTG


GCAAGAAAACTACTAGGAGGACTAAAAAGGCTACTGCAGCAGGCCAGGCAACAGACAAAAGTGACTTAGAAGGGCGGTGGTGGCGGT


GTAGAGTTCTTGAATACATCCCTGCACCATGCCAAGTTTTATATACATCTTCTCCTGTACTGATGTCCCACGCATCAAATCTGTGAT


CAAACTCATCATGTTGCCCCTAAATTCTCTCTCTGCTTCTCTGTTTGTGTCTTCTTTTTCTCAGGAACTTTACCCGTTAGTATTCGT


TTTAGGCTGCAAGTGATAGGAAACCCAAAACAACAATAGCTTAAACAAAACAGAAGTTCTGTCTGACGCCAAAGAAGTCCGGAAAGG


TGTCTATAGCAGGTATGCTGCTCTATGGCATCATCAGGGACGCAGGCTCCTTCTCCCTTGTTGCCCTGCCATCGTTGGTACGTGGCT


TCTTCCTCATACTTCAAGAAAGCTGCTGGAGCTCCAGCCATCCCACCTACCTTTTAGCCATCAGGAAAGAGAAATGGACAAAATAAG


GTTGTTTCTTTCTTGTTAAGGACATTTCCTCGAAGTAACACATGTCACTTTCATTTACATCCGTTGGTCATTCACATGGCGGGAAAA


TGTAGTCTTTATTATTGGTAATCATTGCTCCTTCCTGGGCGCTCTTACTAATGAAGAAGAGGAGACGTGCTGTTGGGCTGCAACCAT


CTCTCAGGCTCAAATCGTTCCCCATCCTTATGCCACTCCCAGCCCCATTTCCAGCCCTCTATTTAGGCACCAAGCTCTATGGTTCTT


ATTCTGCGGTGTCGCTTGAAGTCATCTCTTCCTGCTACCTCCCTGACACAGATCCCTGTCATCTTACACCAGTTTACAGAAGTAGCT


TTTCTGGCTTCCAGTTACCGTTCCTACTATTACCCCTCAAAAACCTTCAATTGCTCCCTCTAGAAGATTAAGTCCATATTTTTAAAT


TTAGTGACCAAGGCCCTCCATCATGCAATTCCAGTCAACCCATGATAAAACCGGTTTGGTTCAATTTTAGTAACATCAGCAACAATG


GTAATAATGATACTTTGCATTCCTACATGGAAGGTTTTATTGCTCACAGAAGGGACAGCACATGGCCCCTGGAGTCAGAAACGTGCG


CTCATAGCCTGGCTTGACAACGGACCAGCTGTGCGATCCTGGGCAAGTCACCTGCCCTCTATTAAATAAGCACCTGCGACTGGCTGG


TTCCTGATAAACCCTGAGCCCTTTCCTTTCCTGGGCCTCTTTCTTGGGATCTGTAGATAGGAAGTAAGCCTGGTCTACCTGCTTCCC


AGGGGATTAGGAAGTTCAAACAAGAGGAGACCTGAACAGCTGGGGGAAACATAAAACACTGGACATCCTCTTCTGTTTTTCACCACG


ACCCTATGAAGTGAGCAGGCAGGACGGGGAACCCACGGTCCCTATTTCGTGGATGAGGATGTGGTGGCTCAAGGAGGCTCATGATCT


GCCCTGGCCCTGACTTGTAGGGCAGTGGAGGAGGCCTGGGCCCTTGGGACCCCGATCGCCTGTGGCAGGGCTTTTGGGGTATGTGTT


CCACTGCGGAGGTGTGTTACAGAGTGAGTCTGTGTTGAGACAAAAGGAGAAAGAACATAAGACGCAAAGTTTTTCTTTCAGCTTGGA


CTGTGCAGTCATTTTCTAATTTCTTTGAGGTCATGCTGTTTGGTACCTAGGAAAGGAATTGTGATTGGTGTTCTAGAAAAACAGTGA


TTTTTAGGGGGAAGCCACTGCCTATTAGTAAGTACAGGCAGAAGCGGCTCATTGTCCTTGAATGCCATGATGTCTGTTTTCGAGGGG


TGGGGTGGGGTCTGGTGACTGGCTAGACTTTTTTGGAGAAAATGTATAACAAACTTAATAAAGTAAACATCTATGTTGTCAAACTTA


CTGAGTTAAGTAGATGTGAATATAGTTAACTGAGTAGTAGCTTTAGAATTATTTTGTCAAGTTTAACATGTGAAATTGTTCCCACTT


AGTTACCAGTATTCTTAAATTGTCTTGTTTATAATTTAAACTGTGCATTTTATTTAGAGAGTAAATGTGTCTGGAGGCTTTTCATTA


TTTCAGAAATTAGAGGATAGATTCCTGAGGTGCCCGGCCTGTCCCTGAGGCCACGTGATGCAGAACTGGAGGCAGGTGAGTCTGAGC


CGGGTGCTCGGAGCCTAGTCAAGGGTGACCACAGGCCGAGGGAGGAGAAACTTCTGACATGCAGTGTCCTCATAGGAATGCTTTGTG


GTGTTATCTCCATTTCCCTGATGGAAAAACTGAGGCCAAGAGCAGTGGGGTAACTCCCCCACCATAGTGTGCAGTTGCTTAATTGCC


TCGCCCCCAGCAGGGGGCATGTCTGTGTGATAATGTCTGCTACAGTGCCCAGCCTCTGTAGGAGGCTAGGAATTGTTTTTTAATAAA


TAAGGAGCACTATCTTCGTTCATGGCCATTCATTCTACACAGGTTCTCCTCTGTGGCCCAGCACTCTGTGAAGTAAGCAGGGCAGGA


GCAATTTTCCCATTTTAGAAATTAGGAAATGGAGGCTTTGGGAGGTAAGCGAGCCAGGGTCTCACTGCTGGCCCGGGGCTGCTGCCC


GCAGAGTCCTCCACCTGGAGCACTCCCATTCTCCGAGGTTCCCTTGCCAGCTGGGCATGGCTGTCCAGACTGAACATCACTCCTTCC


TTCCTTCATCTGCTCAGTGCTTGAAGATCCCAGAGCCCAAGGTCACTTCAGCTAACAAGCTGATGTCCCTATATTTGGGTGAGCTGA


TGGTGCTAATGGCAGTGTAGATCTTCGTTTTAGAGGATAATTATGTTTTCTGAAAGTCTGTGGAGAATTGTGCCATTGCTTGAGGGA


TATCTAATAAAAATCACCCACTGGATAAAAGCAGACCAGAGTTCACCTAAGGAATCATCATCGTCATCATTGTCATCATCTTCCTTA


TCAACAGCCTCATCTCTACTCATGACAGATTTGGCCAAAAAGAAAAAAAATAAAGGAGGCCTTTCGAGGACTTAACACCCGGAGGAC


TTTCCTCCATGCCTCCTCTCTCTGTCTGTCTTCCTAATTTCAGTGAGTCAGTTTTTCCTCCCCATCTGTTTGCTTTCTGGCACTTTA


CACAACTGTCTGGGCTCTTTCATTTTGCCTTCTGTGGTTGCTCAACTCCATCATTTCCCTCTCGATGCTTCTCCTTTGTTCCCTGGC


AGGCTCCTCTCATCTGCCAGTTTCCAGTCCTATGAAGAGTCAGAGGTGGGTTTTAGTTTTCAGGCAGCATTTTTGTTGCCTGGCAAC


GTGTAACAAGCATCTTCTGTGGTGGCTGCTTCCCTTAAAACAGAGCCAGGCTGGGGATGCAGTGCACGAAGGAGTCTCTGGGAGCTT


CTCTGGGGTCATGGGGAGGAGTCAGGGGAGGGGGACAGACAGACAGGTTGGCTTCCATGGTGACTCTGAGTGTTGCCATTCTTACTC


TTTTATAATAGCCTTGGCACTGGCACGCCCTCTCCTGCCCCATTTCAGGCACCCCAGGTGTCCAGTGGTGAAAAGCCTTGGGTTAGG


AGCCATCAGAAGTTCTGTGTAACTTGAGAGGCACCTGCTGCAGCTCCCTGAGGCATGGCCAGCCTGGATGAAGGCTGCTAGGTGGTT


TCCACTGGTGCTGACTCTTGCTTCATCTTGTCTGCACGGGATGCCACAGGCCTCCTGTCTGGAAAGACACCTGGCTTTTGCCTCTGC


AGTCAGCCCAGCTGCTAGTTGTCCCGAGAATGGGAGTGGGAGAGAGAAGGGGGACAGAATGTGATCCAAAAAAACACCTGACTTAGA


GCTGGAGGGGGCTTTAGAGCTTCTTTAGCCAAATCCTCATATTGTACACACGAGGAAACCAAAGCCCAAAGAAGGGAAGCAACTTGT


CCAGACTCACACCGCGAGTTGGGCGGGTCTGAGCTCCCAGCCAAGGGTCTCTCTCCTGGGACTGGACTCTGCCGAGCTCACACATCT


GATGCCCTGTGGCTAGAAAGAGGCAGCATGTGGTGAGAAGTGCACCAGATGCCCAGTTCTCCGCTTTCTGGCCTCCATTTGCTTATC


TAAAAAGAATGAGGTGAACTGGGCTAGAGGGAGCCCCAAGACTCAGTGACTCTGATGGTAAAGCTGACACAGCAGGCAGGCCCCTGC


TGCCCAGGCCTTCAGCCACGTGTCCAGGGCTGCTCTCACCGCCCCAGGAAAGCTCAGAAGCTGAGGGGGTCCTGGGCCTCTGAGCTG


ATGCTCCCCAGGAGAATCCCACTGTATGCAGAGACCCCGAGCACAGCCACGACACTTGTCACCATGAGGCTGATTTAGGGCAAGCCT


CCTGGGCATCTGTGTCTTCAAAGATGGTCTCTTAAGACCCTTATCAAGGATCAGGGCTGCAGCTGCCCACTCCCCTACCTAACCAGC


TCTCCATCTAGTGTGGGAAACGGGTAAGAAAACATTCTCTGAGAATTACAGCTCCTTAGAGCTGGAAGGGGCCCTAATGCACATGGA


CCCAGCCCCCCACCCTTCCCAGATGAAGAGAGGGAGGCCCAGAGCTGTGAGAGTTGATGCGAAGGGGGTTTTGCTCTATTCCCTTCA


GACCCCACAGGTGAGAAGGCATCTCCAGATGGGTCATCTCTTTATCCTGCTCCTTCCTTTCCTTAAGTAAGAATCTCTCAGTTCAAG


AGGCAGAGAAAAGGATTGCTGAAGGCAATCTGTCTCTTCATATCTCTTTCATTCTGCTCCTGGGGCCGAGGAAATGGGTGAGGAGGG


GTGCAGGAGGCCCTTGGCCTGAGCACCAGGCCTGGAGCCTTCCCTTCCAGCCGCTGCTCTCCAGAGCTTGGGGTGCACCAGCTTCGA


GGCTTTAGAAGCTTCTCCAGCAAGAAAGGCCCTTCTGAGGGAAAAGTGTGTGCGACTGGCTGTCTCCATTCCTTTCTCCATATAGTG


TTGACCTTCGGAATTAGCTTTATTCCTGACGTGTACCAGAATTTTCAGTTAATCATGTAAACCAAGGCTCAGGTGACTTGGCTGTGG


GCAGTTGGGGCCGGACCAGCCCCTGAGAAACTACTCCCATCCCAGACTTCGTGACGCTTCACTTGGCCAGAGCCCACTCCCAGAAAG


CAGGGAAATGTGCCTTTCTGCGTAGCCCAGGCCTATGGAAAGAGGCGAGAGGTCAGGGACAGCTGCACTCCCTGGGCAGGCTGCTTG


TGGTCCGGGAGCATCCCGTAGTCTCCCCAAGCCCCACGGCCGTGGGGACCCCGGGTCAGGGCATTATTGTGCATATCCCTGTCCTCA


GGCCCCTCATGCTCAGGCCAGACCCTCACCCAGGTGCCCTTGCCCTCAGACTCCTCCCCTTCCAGCCATTGTCTCTGTCTCCATCCC


TGTCCCTCTCTTTCTCTATCTTCCTCTCTCTCTGATTCCCTGGGGGCTACTTTGCAACCTCTGCTGAGTCAGAATTCTTCCCACTCG


CCCTGACGTCCCAGGCTCCTCCTTGGCACCCTGTCTTCTCTGTGGCAGGGAAAGACGCCCAACCAGAGCTCCCACGTCCTGCCCTGG


GAACCCCACTGCTCTGGGAAACAAAAACAAGAAAATTCCTTCCCAGGGTACTTGTTCTGTGCTGTTCCTCTTTGTTCTTGGTCACAG


GGTGATTCCCACGTCCTTCCCACACTAACCCTGCCTAGGTGAGGCTGCAGCTTTGTGTGCCTTCCACAACATTTGCTTGCCTGGGGA


GCTGCCTGCCTTTAATTATCTTTGGAAAGCATAACTGAGAAGAGCAAGACACCCGTCTTTTCTTTAGGGCTCTTGCCAGGAGCACTG


CCTATGCAGCACTTCCCTCCAGGGGGTGCCATTCACATTGAAGTCTTCGTGACTGGCACTCCTTGGAGTTGCACAGTGCGCAACCTA


TGCTGCTGAACAGGGCAGCCCTGGCTCTGTCTTACTCTCCTGGGAAGCATGGCTCATTATAACACAGATCCAGGATGAGATACCTGA


GAGAGAGAGAATCCCCACCAGTCTCTCCACTCATCTCACCTCCCTTTTTAGGTCTCCACCTCCTCCAAGGTGTAATATGGTCAAAGA


CAGGGCTCCTCCAAGGTGCAATATGGTCAAAGACAGGGCTGTGGATGCAGGCAAGTCCAAGCACACACTCGGGCCCTGCCACTCAAT


TGATGTTTTATTTTGTGCIAGTTTCCTAATCTAGTAATTAATCAAGTGATCCTCCCACCTCAGCCTCCAGAATAGCTGGGACTATAG


ACACGTACCACCATGCCCTGCTAATTTTATTCATTTTTTGTAGAGACAGCATCTCACTATGTTGCCCAGTCTGGTCTTGAAATCCTG


GGCTCAAGGGATCCTTCTGTCTCAGCCTCCCAAAGTGCTTGGATTACAGGCATGAGCCACTGCACCTGGTCTAATTTTCCAATTCAG


TAAAATAGGAAGTGACAGTTATGAGTCTTGTTTTTTGAGGATTAAATTCAGTAATGCGCATAAAGCTTTGGCCCACATGGCACGTGA


TTGGCACTTGAGAAATGATAGTGATTATTGTTATCTCTTCAAATAAGATTAGCATCCAGTCTTACCTACCACACAGAGATAGCCCCA


GAAATAAAATGAAATGAGAAGTAGATCATCTCTAAGATCTTTGAGGAAGTATTTTGCAAGAATCCCAACTACTGTTGTTCTTCTCTC


TGTATATAAAAAACGATGAACTGTGAAGCCCCTTTGCTTCCAAGTCACGCTCTGTGACTGATGGCAGATGTCGGGAAAGGCTCAACC


AGGAGAGAGAAAGCTTGCAGGCGCGGGCGGCAGACTGAGGGCCCCGGGCGGGTGGAGCTCAATGAAAACCACAGACAGACAGCAGCT


GTGAGAGCAAGCAGAGACCCAGAATGGCTTTAAACAGAAAGCAGAGGCCCACAGCACGGAGTGAGATGAGACCAGGTTTAAACGTCA


CTTTCCCCTAAGTCCTTGTTCATTCACAGCTTCCTTCAGTAGCTCTGACCAGCTTTCTCAGCACCTGCCGACCGACAAACCAACCAA


CCAATGGAGGCTGGTGCTGGGGGTGGAGATGGCCAAGAGCCGGTGGTGAGAAGTGAGGGAGAATGGGGAAGAAGGGGCTCCACAGAG


GGCACTTGATCCGGGACGGCTTTCCGGAGGAGGTGATTTCCTAGGCCTAAGGGGCCTCCGGGCAGAGGGGCCAGCATGAGGGAAGCT


CGGAGGTGGGGGAGCATGGATTGGAGGAGAGAATAAGCAGTTGCTTGCTGGGGTGTCATAAGATGCGGCAGTGCACTCAACGCTACA


GGAGCAGGCACGGGCCTTTTTCACCAGCCTAAGGATTTTGGAATGACTCTTCTATCAGCCAACAGTTTCCAACCTTATTTATGTACT


TGTTTCTTTGATTCCAGCGATGCAGGAGAGATGATATTCAGACAGCCGACTTCTGCTGTGGGTGTGCCCCAGGTTATAAATCATTTC


CATCAGGCTAGCTGGAGTCCCGGCCCTTCCTTTCCACTGAAGAAAGCAAATCAGAGTACCAGATAGCGAGAGTGATATTATCACAGG


ATAGCCTTGAAACTGCCATAACAAAAAAAATAAATCGTTCACAAATGTCAATCCTTCAACTACTATTAGCCCCAGAGAGACTGTTTG


TCTACCCCAGTGTGTCGCTGTGCAGAGGCTGAGAACGTCCCCTCTCCTCTTCCCACACCTAGGAGAGGGGGAGCCACTGGTAGATTG


GGAGCAGGGGAGGGTCTGGAGTTTCAGAAAGATTTCCCTGGCTGCAGTGTGGAAGGGGGATTTGAGGGGAAGACGGGACACCAGCTG


GGGAGGCTGCTGTAGTAACAGAATGCTGCCCCCACCACCCCTGGGTACAGTGGTGGCTGGGATGAAGAGCAAGGGCAGTTTTGAGAG


AGCTAGAGGAGCCAACCTCCACCGGACTGACTCACTGGATGTGGAGTGATGGGGAGGAAGCTCAGGAACAGTGTCTGGTGTCCTAGT


GTGGCTGGCTGGATAGCTGGTGGGACTGCCCACGAATAGGAGGTGCAGGAGGAAGAGGGCCGGGGTTGCAGGGGACCTGGGCAGCAG


GGAGAGGGCAGGTAATGAGCAGAGTTGGGGATCGGTTGAGCTTAGTTTACCTGCCACCCCTCCAGAGATGTCCCACGTTGGGGGGAC


CCATGCACCTACTCCAGATGTTACCCTCCCCACTTTACAGCACAGGATTCTGCCTGGTGACATTTGATGCCATCTGTATCTGGCCAC


CCAGTGGGTGCAAAATGCAAGTTTGCTGATTAAGCAAAATCAACCTGAAGCAAACAAAGACTGATGTCCCCAAGGGATAGCCACCTC


CTTGGAGGCAGAAACCCTTTCCCTCTAGGGCAGAGCTTCCTCTGTGGGTCCTCACAGGGGAGGGTGGGAGAGAGACTGAACAAGTGA


AAGGGAAAACAAGAGAGGAGAGATGAGAGGGAGGTGGAGACAGTGCTTCAAAGGAGAAAAAAAGAAAAAGAAGCATGAAAGACAAGA


AGAAAGAACAGAGAGGGGCAAAGGCAGGAAAAATAGAGGAGAAGGAGGAAGAAGATGGAGGGGTTTGGGGCAAGAGTAACAGTGCAG


GCCAGCTGTGCCTGTGAGTTCACGGGGTTCTGCTTATTAAACCCCAGCACTGGCAACTTTGACAAGATGCTCAGAGTTCTTTCCCCG


CCCTGCTTCTCCCTCCAACTCACCTCAGCCTTCTCCTGAGCCTGCCACTCCACCCGCAGCACTGTCATCCCAACCCATACCTGCTCC


TCTGAGATAGCTGTGTGTCCCCTGCGCAGTGGCCCCGTGCCCCAACTTGGCGTCACTTGTCTCCATTGTAACGCGGCCCTTTTTTGC


CTTGGTGTTGCTTGGTGTCTGCCTTCTTCCTAGAACTCTAAGTTCCCAAGTAGGCACCAAGCCAGGCACACAGGAGGGGGCTCATTC


CTATTGCTGACCAAATGAACTCATTTACTAAGTTCCAAAATTTGTGTCAGGCACTATGCAGAGTTTTATATTTTTCACTAGTCCCGT


GCAAGGTTTTACTGCTTCATTTTACAGAAGTGAAGCCCAAGACACAGAGAGGTAAGCGCCTTCCCTAGGCCACACAGCTAACAGGTG


GCAGGGCTGGGATCCAAACCCCCGTCTGTTGGACTCTCTGCCCATGCCATCTCTGCCACGCCATCTCCAGATACCGTGGAAGACATG


CTTCCCATGGGAACAGTGCTTCTTCCAAGCATATTATTTTTCTCCATTTTCATGCATTTTATTAAACATTTCCAAATCAGGAAACAT


GGAAATATTTTTTTAATAAGAAGAAAGAAAACATTGCAAATTGAGAAACTGACTCAGAAGGATTTGCCAGATGAGCCATCTGGTTTT


TAATTTCAAAGAGGTTGACAGTGCTTCCCTCTAAGAAGAAAATGGACTGTGGAAGGAATGCCAGCTGGCTTCCCTCAAATGGTGCAT


CCATTTGCAAGGTGGAGAAGTTGAGCAAGACCAAGAGACCCAAGAGAACAGAAACACACTCCAAGAAAAGCTTGGCCAGTGCTGGTG


TTGAAGCTTCCCCGCTGAGGCCTGCAGAGGTTGCATCCAGCTGTGTGACACCAGCCAGCTGTCCCACCTCTTCCAGAGTTTCTCAGA


AGCTTCTACAGGAAACCACTAATGGAGACAGAGATGCCACCACCTCGGTGAGAAAAAGCCACACCAACCAAACTCTCGTTTTCACAG


AGCAAGAACAAGCTGTGGTTGTTTGGCGGCAAGTCGCATTTGTTTGTTGGAGCCATTGTGCTCTGGTGGTGCTGGTTTTCTCTCCTT


TTAAAAATAACTGGAGGCCTTGCACCATGCTGTTAGTTCTTAGGGCTGGAAATAAAAGACTAGATTTAGAGTTGCCTTGGAAAGATC


CAGGGCTGTTACCTTGAATTACCTGGTAGAGGAAAACGTCGTTATTTTCCTAAATTCAAAGCCAACTCTTGAAAAATAGGACACAGA


GGTGAAGTGGATGGAGGGGTGGCTTTATACATGCATGTGGTGTCCTGGGCACGTGGTTTGATAGGCTTGTGATCAGCCCTGAGTCTT


CAAAGCCATTTATTTTACATTTTAAGATGTTTATAAGGGAAATTGTTTTTGAGAAAAGAACGAACTATTTTTTTTTTTTTTTTGCCT


TAATCTGAATTCACCCACTGGCACAAGCAGTAATAGCCCTGAAGTCACCCTAGGCCATTTATTCCTCAGCTGCCTTTGAATTTCAAT


GGGATTCTTTCACACGCCTCAAGCATTTCTGAAATGCTCCTAAACTAAAGGAACTCATAATACCCTTAAGAAATGATGATTTCACCC


CATTTTCTCCATAAAGCTGGAATCACATGCCCTAGCATGCTGAAGGTACTTGATAATTAGAAGTTGATTATATTGGGGACCTGGACA


AAGGCAGAGCTGGGAATGGGAATAAAACCCAGGACTCCATGAAAGTCTCTTTCCTTTCATAATAGCTTCTAATTCAGGCTTCTAATA


GCTTCGAATGCCAGTCACATACAGAGCCTCCCGGCCATCACCTACTGGCAGTGGCTGAGCGGGTATTTTGCCAAGCTACAATGGTTC


CTGCCCAGGCACACGGGTGCTGCCTCCACCCCCCACCCTGTGCCCAGCTCACTACAATTGCCATCTTTAGCAGCCGAAAAAATACAG


GTTTCAGTCCCAGTCTTTTCGCTTAGTTGCTGTGAGAAGTTAGTTAGGTCAGTTACGCACTGGAGCTTTGCATTGATTCACTGTAAA


ATCAGGTAACAGCTCTTATCCTGCTGGTCTTGTCCCACTGGCTTGTGAGAAAGACGAAGTGGAGCCATTCATTCATTCATTCATTCA


TTGGACAAGTATTTATTGAGTACTAGGGATACAGCAGTAAAGAAAACAGAAAAAGTCCTTTCCTCCATGAACCTTATATTGTAATAG


GGGTTGTCAGTCAATAAATACAAAAATAGGCCACATATCTATTATGTCAGGTGGTGATAAGCGCTGTGGAGAAGAATGACTCGGGAG


AAGCTGGCCTGCTGGGTGTGGGGCAGTAGTGCACTTGGAGACAGGGTGGGCGGGTAACACCTTACTGAGAAGCTGACATTTGTGCAA


AGGCCTGAAATTATCTGGGATAAGAGCCTTCTAAGTAGAGATGTCCCGTGACTTATGATGGGATTACTTCACAATAAACCCACAGTA


AGTGGAAAATATCATAAGTTGAAAATGCACTGAACGTACCTAACCTACTGAGCATCATAGCTTAGCCCAGCCTACCTTAAACGTGCT


GGGAACACTTATGTCAGCCTGCCGCTGAGCAAAATCACCCGGCAGCACAGTGCCCTGTAGAGGACCTTGTAGAGTACTCATGATCAC


CTGGTTAACTGCGAGCTGCCCAGCATCAGGAGAGAGAATTGCATCACAGATCCCTAGGAAAAGATCAACATTCAGAATTTGAAGTAC


GCTTTCCACCGACTGTGTATTGCTTTTGCACCATTGTAAAGTGGCACCATTGTAAGTCAGGGCCATCTCTGAAAAGAACAGCAGGTC


AGGGGCTCTGAGGCAGGAGTAAAGCTGGCTGGGTGAAGGAGCTGCAGAAACCCCAGGTGGCAGGGCCAATGGGCGAAGGTGAGATGG


GCTCAGAGAGGCCCCCAGGTTGGGGGCCCCAGGGGACTTCGGCTTTTTTTCTGAGGGATACAGGAACTTTTGTCTTACTTTTTTTAG


AGGGCCTCTCTGACTACTGTAACAGGACTAGCCTGAGGCAAGCGTCGCCCAGGCAGAAGCAGGGAGGCCAGTGAGGCAACTACTGCA


GTGGTCCAGGTGAGAGGGCGGTGCTGATCCAGGTGAGAGGGTGGGGCTGGAGCAGGTAAGAGGATGGGACTGGAGCAGGTAAGAGAG


TGGGGCTGGTCCAGGTGAGAGGATGGGGCTGGTCCAGGTGAGAGGGTGGGGCTGGACAAGGTGAGAGGGTGGGGCTGGTCCAGGGTG


GCCACAGACCAGGGATGACAGGCGCTCCGATTCTGGAGATATTTTGAAAGCAGAGGTGACAGAATTTGATGGAGATAAGGGGTTTAA


GCTGCAAGTCACCAAATGAAGAGAAGGGGCTGCAGCCACCCAGAAGAACAGCGAAGATTAAAAGGAGAAGCTGGGAGGAGTTTCTGT


TTTCCTACACAGCAGCATCTGCTGCCTGTTCTTTCTCCACATCCGTGCAGCTGCCCTTGTCACTAGGACGAAGCCCCAGGTGAGAGG


CTCCTGCAGAGGCTGTGACATACCTCTATCTGTATCACTTGCTGAAGGCTGATGGAGCCCGTGCACATTCACTCCTCACCGCGGCCT


CGCGAGGCAGGCAGGACGGCATCATTACACCCTGCTTCCCCGAAGAAGCAGCAGGCCCTGAGTCCGTGGAGTGATCTGCTCAAGGTC


ACAGAGCCATTTGGCATGAAAGGCAGTCTCTGGGCTCCAGATCTTGTGTTCTTTCTGCTATGCCAAGGCTAACCATAGACACACGAG


ATGAAAATAGCACTTTTTTTTAGTGCACCTATGTGCCCGGCACTGCTCTAATCATTTTAGACATATCAGCTCCTTTAACCCTCACAG


TAACTCTCTGTGAGGTGGTACAAGTATTATCCTCTTTTACAGGTGGGAAGACTGAGGATAAGTTCATGCAGACATTAAGGTGCAAAG


CCCGGATTCAAACATAGGTGTTCTGGCCCTGGAACCTGTAGGTTCAGCTATACCCCAGCCAGCTTTGCGGCCTTTCTGCAAGCCAGT


GTGTGGGCAGTAGGTGGATGGTGCTGATGCCACGTGTGGGAGACACAGGCAAAGAGCTGGGGTTGGCTGGGTGGGTCAGGATGGGAT


TTGAAGTGGGTCCTGAAGGGCCAGTTAGAAGGCATCAGGGAGGACAGGGCAGGAGTGACAGGAGCAAGAGAGCCATGTGTGCAAGGC


AAGCTTGGAGCACAGCAACCCTGAAGCGGTGGTCAGAGCATGAAGCCAAGGAGGCACAGTCGAAGGCGGGAGGAAAGCAGGCCAGTG


AGCCGCTGCAGATGCCAGAGGAGGGCAGTGTTCCGAGGAGAGAGGCACCGGTGCGGTCAGAGGCCGCCAGGGGGCCAAGCCAGGTAC


GTGTTGTTGGCTTCCTCATTGGAGAAATTCGCAAGCACAGGGTTCACAGCTCAGTGGGCAGGTCTGACTGTGTGACTCTGAAGATTG


ACCGGAAGGCAAGGACGAAGCAGTCCATTTGGCTGCTTTGGAGTTCTGCAGAGGATCTGGCTCAATGCCTGCAAATTTCCAACAAAC


AAATCAGACCCAGGACAAATGGCTAGAGCCGTCATATCATGTAGATCCATGTCAAAAGAATCCTTTTTTTTTTTTTTTTACAAAACT


AGTTTTAAAAAGTATTCAAATTCTTTTGGAGAATAAGGAAGAAGAGGCAGTCATTTCACTTTGGCTTATTTTCTGTCACCCTAGTGC


TGTAACAGATCACAGCTAGTGTCATGAAGCTGAGTTCTTATTAATAGTGAGAACTGACTCCAAGCTCAAGGAATTTGGCAGCCACCT


TGACAAAGGTTTAATCTGCTGAAGAGAACAGCTGAAATCATTTTAACATGATTCACTGAATTACTGAAGCAAGCCTCACTTTTGTAG


AGGGACAGGAAAAGCAGCATGCAGGCCTTAGTCAGTCCACAAGTATTTTAGTGAGCCCCTATTATGTGCTAGACCCTCAGAAGGTAC


CAAGGAAAGGCTACAGAGAATACTGTAATATAACTTCAGGGTTAGACAAATAGACCAATGGAACAGAATAGAGAACCAAGAAATAGT


ACCACTTCCACATATAATTTATGAGACAGAGGGAGCATTGAAACCTAGTAGGAGAAAGGATGGTCTGCACATTAAGTGAAACTGAGA


TAATTGCTTACCCATGTGAAAAAAATGAAGTTGTATCCCTGCCTCACACCATATGCAAAATCAATTCCAGGCAAATTGAAGACTTAG


AAAGGCAACATTTTAAAATATGTAAAAATGTTACAATCTCAGGGAGGGAATGATTTCTGCAAAAACCAAATAACTGCTAATTATAAA


TTAAAGGATGATAAAGTCACCTACAGTAAAATTTAAAACTTCTATTCATCAAAAATACTGTAGAGAAAAAGGCAAGGCACACACTGG


AAGAAGATATTTGCAACACACAAACTGACAAAATTCTTATTATCTAGAATATATAAATAACTTTTAGAATCAATGAGAAAAAACAAA


AACAAGCCAATAGAAAAGTGGACAAAAGTCATGAATGACACGCCACAGAAGAGAAAGTATGAATGACAAAGAAACATATGAAAGGCT


ACTTAAGCTTTTATCATGGAAACGTAAAGTCAAGTCTTGATGAGATCCCAATTCACCCACTAGTGTGGCAGAGATTAAAGTCAGACA


ATGGCAAGTGTTAATGAGGATATGGAGAAACAGGAACTCTTATCCACCTCTGGTGGAAGCCTAATTGGCACTGGCATCTTAGAAAAC


AACTTGACATTTCCTAATGAAGTGAAATATGTACATATCCTACAAACCAGCAAACCCAGTCTTAGGTATGTGTCCTAGAGAAACTCT


TATGCAGTGTACCAGGAGCTATGATTAAGAATGTTTGGGCTGGGTGAGGTGGCTCATGCCTGTAATCCCAACATTTCAGGAGGTCAA


GGCAGGAGAATCTCTTGAGCCCAGGAGTTTGAGGCTACAGTAAGCTATGATTGTGCCACTGCAGTCCAGCCTGGGCAACAGAGTAAG


ACCCTGTCTCTAAAAATACAATAACAATAAGTCAATAAAAAATAATGTTTGTAGCAGTATTTCTCATTAGAGGAAAAACCCGTAAGC


TATCCCACTGTCCATCAACAGGTGAATGAATAAATAAATCATGCCATATTCATATGATGAAATACAATACAGGAATAAAAATAGACT


ATAGCTACATATGTCAATATAATATATATGTTGAACAGAAAAGAAGCAATTCATAGAAGAGTTCACTGTATTAGTTATCTGTTGCTA


CATAACAACTTGCTCCAAAATTTAGCAGCTAAAAACAGCAGACATTTACCATCTCAGGGTTGCTGTGGGTCAGGAATTCAGGTGCAG


CTTAAATGGGTACCTCTGCCTCAAGTTCTCTCATGAGATTGTCAGGCTGTCAGCCAGGGCTGTGGTCTCACCTCAAGGCTTGACTTA


AAGAACACCTGCTTCTAAGCTACTCATGTGGTGGTTGGCAGGCTGTGTCCCTTGCCATGTGGCACTCCACGGGCTTGCCTCCCGACA


TGGCCTGTGGATTCTCCCAGGGAGAGTGATCCAAAAGATAACTAGTGAGAGATCACCCAAGACAGAAGCCATGATCTTACCATAACC


TAACTTCAGAAATGAAAGTCTATCACTTCTGCCATACTCTATGTGTTAGAAACCAGTTACTTGGTCCAGCCCACACTCAAAAGGAAA


GGATTGCAAAAGTGTGTGAAGACCTCAAGAGGAGGGGGGATATCGAGGTCATTTTAGAAGCTTCCTACCATACTCTTGTGGTATGAT


TTCATCCTTATGAAGGTCGGAAATAGGAAAAATGAAATTACATATTGCTTAGGTAATCCTGCCTACATGGAAGCACTATGAAGAAAA


ACGAGGAAATGATAAACATGACATTCAGGGTAATGATGATCCTGGGGTGGGGGGCACTAAGAATGCAGAGAACATACAAGTAGATCC


CACAGGTTGGAGCTGGATGGTGAGTTCATGGTGCTTATTTTCTTTCTGTGTTTCTTGATGTCATTTAATGTTGCATGTAGTTTTGTT


TTTTCTCTTTGGTTTGGTGTTCTGTTGATATGATCAAAGTTACATGTGCATACACTGTAGAGTCAATCCTTCCGTGGTATTTGCTGT


CTTCCACCAGCTCTTCCCATTTACTGTTCTCCAGAGGCAGCTACTTTTACCTTCTTTTGCTAATTAATTTTAGTATTTACCTCCATG


TCTGTAAGTAATATGTGTGTATTGCTACCTTTTGATGCTTTGGTTTATTTAGGTATTATCTATTCCCTTCCCACTCTGGGAGATGAA


AATTTAGCTCCCTTTCCTCTCCTCCAACTCTTCCTCTCCCTTCATCTTCCTTTTATAATTACATCATAATTTTGGTTAAAGCAGTAA


TCAGTGTTTACATTACTCAGTCAACACTAATTTGACTCTATTCATAGTTGAGCCTTGTAGTAAAAAATATGATAACTTTTCCCTTCC


TGCAGAACTTTTCATTTTTCCTGGAGTTGTTAATGATCGTGTTTGTTTGTTTGCTTAGTTTTCTATGTATTCGTCATTAATGCAAGT


GCAAACTCTGGCACTTGTCTAAACCTCTTTTCAGGATGTTCAGGCACATTAAGTTTCCTATCAATTTCATCTCCTTGGAAGTGTCTC


CCAGAGCCTCTTGACCTGCTCCAGCCCGGACGGGTTGTCCTCCGCACCTGGTGTGCACCTGTCCTATGAGGGCCTCCCTGTAGCATC


ACCCTGAGCTCGTTACCTTTATTCCTTGTCTTCCTCCTTGGTTTACTTCTTTGTTTTGGTGAAGCATACCTCCTGTGTCTTCCTGAG


AGAGGGTGCATGGGAGGCAAACCCGTGACAACCTTACGTATCTGAAAATGTCTTCGTTCCACCCTCAGACTGAACTAATACTTTGGC


CAATTCAGATTTCTGGTCTCTGGTTTGGAATTCTGATTTGGAAATAATTTTCCTCCAGAATTTTGAAGGCTTTATTCCATGGCCTTC


TAGCTTCCAGTGTTGCTGTCAAAAAGTCCGAAGCTGTTGTAATTTCTGGTTCTTTGTATTTGGCCTCTTTTATACCCTCCCCCAAAA


CCCCTAAAGCTCTGTAGGATTGTCTCCTTTCCCCTGGTGTTCTGAAATTTCACAATAATGTGCCTTGGTGTGCATCTATTTTCATCC


ACTGTGCTGGGGACAGTGAGCCTTTGATCTAGAAACTCATGCCCTTAAGTTCTGGGGATTTTTGTTTTTGAATGATTTTTAAAATAA


TTACTTCTCTCCTTCTTTCTCCTTCTTTTCCCCCCAGTTGTTTCTTTCTGTAACTTCTACTGTTTGAATTGGGAGACTGATTCACTA


ATTTTCTCATATTTTCTTTCCCTCTCTCTCCTTTTAAGAGATGATGGGGGTCTTGCTCTGTCCCCAGGCTGAAGTGCAGGGGCACAA


TCATAGCTCACTGCAGCCTCAACCTCCTGGGCACGAGCAATCCTCCTGCCTCAGCCTCCGAGCAGCTGGGGGATACAGGCACACACC


ACAATGCCTAACTTCATATTTTCTTTCATTTTCATTCTTTGTCTTTTTCTGCTTTTTGGGAGAATTCCTCGATTTATCATCTTCCAG


CCCCTCTAGGAAGACTTTTTTCATACAGCATTCCATTCTTGTCTCGTGGGTCCAGTATCTTATTTTCTCTCTCTTACGTTAATTATA


GGATTTTTCCTTCAAGAGTTCTCTCTGTGAATGGTCTGTATTTGATCCAGAGTTCCTTCTTTTTGTTTGTTTAATTGACTGGTTTGA


TCTGTGTCTTTCATGTTAGAGACTCCTGACTGTCTGGGGATTCCTGGTTGCCTGTTTATTTTTAAAAGTAGGAGACTAACAACTTTG


AGCTGTAAGGGATTTGAGTGAGCAAAAGTAGACATATGTCTCTACCATCTTTGCCAAGTCATACAGTCTTTTGTATCTCTCATTTAT


TTCATGTTAAGAAGTGAAAAAAAATCCATAGTCCACACCCTGAAAGATAAATCAGTAACTGTAATAACTACCCTTGAGCTCAAAGAA


AAATTACATCTTTTCCTCCTCAGCCTTTAAAGAAAAACATGGAGCTATCCCCCCCCCCAAATTTTCTATTGCAAAAAATAGCACAAG


ATTAGTATGTGAGTTTGTGACATGTGTAAACCGCTCTAAAATTGTGAATAGGTTTAGAAACCTTTTCTCCCTCCTCTCTACTCCCAC


AGTCCTGAATCACCAGCCCAGCCTTCTGGCTCATCACTTCCTGCTTGGTGAGTTGCATGTATGTCTTATCTCCATGACGAAGCTCCA


AGCCACTGGAGAGCAGGGTGCATGTCCAATTCATCTCAGCATCTTCCGTAGCCCCCACCAGAGAAGCGATCACTGAAGGCTGACAAA


CAACGAAGGACACTCTCAAGATCTTCACTCCTCTCCTCAGCACACACAGTTAGCACGCACAGGAGTTTATTATGGTGAATGAAAAAA


GAAACCCACAAGAACATAATTTATATGTAATTCCACTTTGATCTCTAATCTCTTTACCTTGGCATCCTCCCACATATGAATAGGATG


GTCCATGATCCTAAGGGCAGCCAAACAGCCAGGGAGCACGAGTTTAATCCTCAGGGTTTGCAGGGAAAGGAGGACTGTGGAGACCCA


CGTGCACAAGAAAATCCATGATGTGCACAGAGGGCAGGCTACAAATTAATCCTAACTTCATGGTTCGGTATTCAAGGCTCTCCATTG


CTTCTCCCTGGACACCTGCAAAGCTTCTAGCAGCACTGCTTATCTGGGGCCTGACCCCTTTAGTCAGTCTTTCATGTAGAAGAATCA


TTTTCAGATACTAAGTATCTCATGTCTTTTCTTTGTCCAAGAACTTACAGTTGATTTCTTTTGTGTCTGTATCAAATAGTTCTCCAG


CCTAAACTTCAAGACATCTTCATGAATGCCTCACCACTCCACTGCACGTGTAAATCCATGCCCCTGTATTTTTCTGTCTATTGTTTC


TCAGACTGATAACACCTGCGCCCTCTCAGCAACAATAATGGCTGACATTTAGTGAGCACTTAATTTGGGTCACTGTGCTGGTATTGC


TTGTGGGTTATTTTACTTAATCCTCCCATCATTGGATAAGGAAATTGATTGACAGAGAGGGCACGTCACTTGCCCACAGCCATGGAG


CTACTTAACTCTGGAGCTGGAGCTCCAAGCCAGGCAAGCCCAGCCCAGCCCAAGATCACTGGCTCAGCTCAACTCCTCACTGCTAAA


CTGCCTCAACCACATTTCTTCAGACCTTACCCAAGACTTATCTTCCAGGAAATGTTTTTCGGAAGAACTGAGGACCCTGGCTGTGAC


TGTATTACATTTATGTGTTGCAGGCTTGTGGCGTGGAGCTGCCTTTACGTCTTCTCCCTTCTGTGTCCCCTCCCACAGTCACTGAGT


CTTGCTGCTTTAGAGAAGCTAAAGTCTGATTTTCCACCACTGCCTCAGCACAGGGCCTGAGGATAGGGTCTGCCACCATCCCTCCAG


CCAGAAAGCAACCTGCTGGGAAGGGAGGGGTTGCATTGACCTGAGGGCCTAGCAGGGCAGAGTGAGCAGGCCAGGGAGACAGCTGCC


TTTCCAAGGCCACAGCAGAACTGGGAGGGGGCTGATGCGCTGGGTCACGGTCAGGGGTAGACGCAATCCTGGGAATCAGAGTTGGGA


GCCACCAGCCTGTGCTACTCAAGGATAGCCAGGGGAGCAAAGGCAGGCCCAGCCCAGGGAAATGAGGCCCACGCAGCCAGCCAGGGG


CCCCTAGGGTGGTAACAGAGCATCCCTGGGGAGCAAGTATAGCAGATGGAGTGGGCAGGCAAGGCCATCTCATTAGCAGAGCTTTGG


GGAGGGGGTATCTTTTCTTCAGATGTCCCCAGAAGTACCAGACACCCATGTCCTTGTGCAGACAGCCACAAAAAGGCTAATGCTGTG


CCACCCACTGGGTCTCCAGTTGCTGGCCAAGGACTCAAGTGGGGCTGGAGAGCCCACCATTGATGTGCTCGCGGGAATCTGCTAGGG


CCGGGCTCCGGTGGGTGAGAAAGGCTGTGGCCTGCGTCTCTGTCCCAGCTTTGCACACCTGTTTCTTGCCTGGTCACCCCACCTCTG


TGTCCTGTCTCTTCAGATACCCTGCTCGCCACCCGCCGACCATTCTTCCCAGCAAGCTGTGTTATCTTGTCATTCCTGTGCTCAAGA


ACCCAGAATCTCTTCTAAGGCCTCTAAGACAAGATCCAAGCTTCTTCTCCCAGAATTCCAGGCCTTCCTAAATCTGACCCCTGGTCT


CTGAAGCCCCCTGGTCACCTGCTACTGGAGCCCAGGTGCTCTCCTCTCACTGAAGCTTCCTCATTATTCCCAAGACACACGCCAGTC


GCTTTTGCCTCTCTGATGTTGAGTGAAACAGTGAAAGGAGCATGGGCTTTGCTTCCTGTGTGTCCTTAGGCAAGTCACCCAGTGTCT


CCGTGCCTCCTGCTGCTTACCTGGGAAATACTTTAAAGACTGTTGTGAGATGAGAATGTTTGCGTACAAAGTGCCAGCCACACAGTA


GGTGCTCAATACATGCACAGTATCCGTCATACCATGCTCTTGCTGCTCCCTGACTTGATGGCCCTGTCCCTTTCTGACTGGCTGAGC


TCCTGTCTCCTTCCAGGCCCATCTCTAGATGCATCTACACATGCAGCCTGCCCTGCACGCCTCACTTAAGGCGCCAAGGGAAGGAAA


AGCAGCATTTGCCTATCACTCGCTGGGCACAGACCCTGTGGGGGCATGGAGATTCCTGATGACGGCAGCGAATCCTTCCAGGGGGCT


TCCTTGTACTAGGCCTGTCCCGGCACGTTGTGTGCATTAACTCACGGAAGCCCCAATGGTAACTGACTTCCATAGATTAAGGTTCCT


AAATGGCTTTTCTGCTCTATCCAGCCTAGTAGGTTTGGTCTCCCTGGCCCTTTGTTCTTAGCTTTCCCCATCCAGTGGCCTCCAAGT


GGTTAAGAGGAGATTTTATCAAGAGGTGAAGCCCTACAGTATAAAATACAGAGTCTATTGTGTGTTGTTCAGGCTGATCCCATTAGA


GAACGGTTTGGAAGAGGACTCACCTTCACCAGCCCTGCCACCCAGCCTGCAACCAGCTCCCTTGCTGCACTTTGTATAAGCCCTGGG


CTTTCATTAGGGTTCTCTGCCCAGAGCACCCGTTCCTCTGGGCCTGCCTGGAAAATGCAAGCCTTGCTCCTCTGTGGCACCTCTGTG


GACCCTCATGTGTTTGGGTCAAGGTCATTGCCCTCTGCCTCCATCCCCAGGGCACCTTGTCCACCCCCTGATTGCACCCCTCTGCAG


ATGTCTGCCTCCTTGGCAAACCCCTCTCTTGGGCTGGGTCCCTGAGGGCAGGGGCTGTGTGGTATTCATCTCTGTATTTCAGTACTT


GGCACAGAGCCTGGCATGCAGCAGGTCTTGGTGTTGGGGATGAAGGGAGGGAGGAAGGGGATGGGGTGGAATAGGCATCCGGGCAGA


GGAAATGGTGCTGATGTTTCCAGTTGGTTCCTCCCAGGGCGGGGCAGCTACAAGCCCCTGTCTGACTCAGAAAGGGAGGCCTCTGTG


GACACCCCAGAGCCCCCTCTAGAGACAGCTCCACGAGAGCCCCAACCACCACAGCTTCCCTCCAGACCCCCGGGAGATGCCAGTCTT


TGAGATGCTTCAACTTTCTTAGAGGAAATCGCTGAATATGTTTGGTAATTTTTTTTTGACATTTTCCCTGTTCAGGAGCTTGTGATT


TCAGATTAATCACATCCACATACATTTAGACTGTCGGCTTGGAAGGGAAAATTTGAATTTTATTACTGCATGATTTCATCCAAAGCT


ATCTTACCAACACTAAAAGGATGTCTACAATGAGGTGCAAATCATGACAAAACATTTTATCTCTGGGACCAAGCTCATGGCGGGAGG


CCAACGGGACGGGGGGCTGCAGGTGGGACCTGGGTGGGCACAGTTGCAGCCCCTTCAGTAGCCTAAAGAGATCTGTGTGAGCCACCG


TCACTGCTGCCTCTTCCTCAGCAAAATATCTCATTTCCTTCCCCGCTCTAGGTTTGCCCACAGCCCTTACTCCCAGGAATGGCTGTT


CATCGACTAACTCCTGTCTTCCCATTGGCAGGTACCATGACCAGCAGGACGTAACTAGTAACTTTCTGGGTGCCATGTGGCTCATCT


CCATCACATTCCTTTCCATTGGTTATGGGGACATGGTGCCCCACACATACTGTGGGAAAGGTGTCTGTCTCCTCACTGGCATCATGG


TGAGTACCCGCCTCTCCCCATTCCCTACCCTTAAAATGTGGCAAAGAGCTGAACTCTTTCTTGCAAGCACATAGGGGCCTTCCTAGC


CGCAGAGCGGGGGGTGGCTGTTAGTTAACCGACCTGCATGTGTGTCCCCTACACATAAAATGTCAGGTGGGAAATCTGCAATGGTTT


CTCACTTTTCAGTTAACTTTTCTAAGGTAAGAATGAGACCTGGACTCCTGGCAGTTAATGGTCTATTCACAGCTCCCTCAAAATGGG


CTGGGTGAAGCTGGTCCTGGCCCAATGCTCTGATGCCCACCCCACTGCTGTGCAGCCACCCAGTTTGCTCACCTCCAGTGAGCACTG


GAGCTTGCAGTTTATTGTCCTCCTTCCTGTTGCCTTGGTCCCACTGACCTTGGCACCATTTCTGATCATGTTTAGCTGGAACTCACA


GAAGCAGGGACTGGGGAAAGAGCACTGAGTCGGCCTTTGGGACCTGAGTCCTGGACGGGGCTGTCCACATGGCCCTGGGCTGGCTCT


TGCCTTTCCCAGGCTTCTGCTTCCACCTCTGCCTATGGAGGGGCTGGGCTCTGAGTGCCAAGTGCTTTGCAGCACTGGCATTTGGCA


AGGCTGTGATCCCATCTCCAGGTGCCCAGCAGGTGTGCCGTGCCCTTTCAAGGTGTATCTCTCCTGCCCAGTGCCCTACCACCCACA


CTCGACACTCTCGCGGAGGCACACACTCTCACCTGTCACATGGCCATCACAGTGTGGCTTATGAGAGGGATGTGGGGTCTGAGTTTC


TGCTCACTGTGGACCCTGGGCCAGGCACTCTGCATATTGGACCTGAGCATCCTCCAGGGGAAAGTGGAGATGGAGGGCCTGCCCTGC


CCTCCCCATTGGTTTGTGCAAGGACCAAATGCAATGATTTATGTTAAAGTGCTTTGAAAACGAGAAGCGGCCACACACAGGTCAGTG


TTGGTGGTGTCCTCAGTGTCCTTCAGTTGCAAATTGGTGAAGTGTTCCCTGGGCCTCATTGCACTTTGGGTCCAGGACAGGCAGCTG


CTGCTCTTTGGCCTTCGTCCTGGAATCCTAGAACAGTGTCAGACCAGGGTTGGACACTTTTTTCAGAGGAGGAAACTGAGGCTGAAA


GAGGAAAGCACATCTAAGCCTGGGTAGTGTTGGGGGAGGTGGCGGGGTGAGAAGTGGTCAGGCTGCTTGTGGTGTGGCTCTGGGTCT


CCATGGCTGGAGACCGCAACCCTCCCAAGGACAGCCCCCCGTCCACAGCCCCCCTCACACCTTTGTGAAAATCCTTCCTTGCAGTGA


TCCCTCAGATTCCATTTGTCACCCCCGTTGCCTCCAGAAGAGATGAAGACCCTCTTTCTGGAAGGGCAGTGACCCCTTTCTGCAGTG


CAAAGGGAGGGCCGCAGGTCTTCCTGCAGGGTCTGAGTGAACGCCTCACAGCGGCTGGGGGCTGCCCCCACTCCCCACCCCACTCCG


TCTTGTTGGCTTCCTGGGGCTGATATTGGTGGACCAGACGGTCAGACCCAGGCTTGGGGCAGTCAGCCTGCTGAGCAGGAGGGGCCA


GGCTCTCTCCTCCTTTCTGACTCCAGTCCAGGGCAGGTCCCTATTAGCAGGCAGGTCCTACGACAGCAGCTAATGACAAAAAGCTTA


GCGCTGGGGTTGTGATAAATCACGGGTAAGTGCAAGGCTTTAGAACAAATACCTCCCATCGGTTAGTAGGAGTCTGTCTTGGCATAG


CACCAACTGTCACGAGGAAACCGGGGAAAGACGCTTCTTACCAGAAAGGAATGAAATGCCACTGAAGGCCAAATCTTTCCTTCTTAG


AGTCACTCCTGGGGCTTTGTGCCTCAGAACCAGCTCTCAGCCAGCGCTGGCACAGAGCAGGGTTGCCAGTAGGTGGATGGGCCCTGC


CGGGAGCCTCTGTTATTTTAAAATACCGACCTTTTCCCCTCTCAGCACATAGCTGTCCCCATCCAAGAAGCAGCACCCCAAAGACCT


GGCTTCCTGGTTCCTGGACTCCGCATCTCCTGGCTCTACTCTGGCACAGCTGAGCGGAACAGGCGAGACCCTGGCCCCACCCCTGCC


TCTCTTTGGGGTCCGGAGGCTGTTTGTCTTTCAGCACCCCCTTTTGCTGTCTGGGTGTGCAGTGCTCCCCCAGAGAGAGCGTTCTCT


TCCCTGTGGATTGAGGTGTGATCAAAGTGGAAAGAAGAAACGGACGATGAGGAGCCAATTCCCACCTTCCATATGAAAAATACAGCC


CAGGCCTTTCATCTCTTTTTGTACAAAACCCTGTGCATAAATATACACCTTTCTATATACAGGAACAGGGAGGTTTCCTCTATTTAT


TGTCAGTGTTTTTCACCCAAATTAAAGTCAGTCGCCTCACTCTGGGGTCAGCCACAGTGAGGAACCCTGGTGGCATTTTTCTAACAA


ATGTGATTTTTCTAGCTGAGTCACTCCTAGCCAGGGTTTCACTTTGCTGAGGATCCTTTCCCCTCCTCCTCCCAACCTCCCAACACT


ATGTATAGCTCCCAATTATTATTGCAAGTGCCTTTACTAAAGGTAGGGCTTCCTGTTTGGTTACCATGGACACCAGGAAGGCCAAGG


CAAGGCCTGCTTGGGAAGGGAAAGGAAGGATTTGTGTGTGTGTGGCCTGTAAATAGTCTTAATCATTGTTTTCTCTTGGCAATCCCA


GTAACAATGTAATTATCAACCATTAAGCAGGGTATATAATTGTCTGAACAACTTGCCATGGCTGGCACAGACCTGGTGTGTTTGAGA


GATTTCACCCACAAAAGCAGCTACATTAAAGTCCAGCATCTTTCCATAAGGATTTTTCATGATCATGGTGACAACACAGTAGAGAGA


AAGCTGTCAATATTTAGTATCCAGAATTGGAAATGACAGTGCAACCTAAAAGATGTGCAATGCTGACCTTCTGATTCTGTAGGCATC


TGGAAGACCCCAAAGCCCCCAAGGCTGCTTGGCATAACTTTGTTTCAATCTAGCCTCTTTCTAAAGCTGGACTCTCTCTGTAGACCC


TTCATCAGTTATGGACAAACAGGCAAAAGCTTCTGGATATCTGCAGGGACGCTGAGCTTTTCCCCAATGGCCTCATGAGAGATGCCT


CTGAACTGCCAAGGGAAAGTGATGATGAAGTAAAAGGTAGCACAAATTGAGTCATTTCGGGAGGAGGCAAAAAGAGGGCTCAGCAAG


ACATCTGCTTAATGTCAGTTTTAGAAGATGAGCTTCTCCCGAAACACCTTGGTTTCAAACCAATTGATGTTATTTTAGTTGTTGCAT


GGAATCTGTTGCAGAAACAGAATCCAACTGTAAATCCTCCAGGCTTCCCTCCTCCATTTGTCACTTTCATTTGTGTTTTATTTTATT


TTATGCTTCTTTAGTTAAGAACACCTCATACTTTTCCCCTTGGGATACTTGTTTTTCCAGCTTCTAAGGTTTTCCAGCTGGAAAATG


TTTCTTGAAAACAAGAGGTGGGAGGACTGGTGTGGAGGAGTCTCGGTCCAGATTTGGGTCCGAATCTCTAGAGTTAGGCGTGTTCAC


CCCGTCCCAGCCACCCTCTCTCCATGCACTCGGTGCTCCCTCTCGCCCACGTGCCTTGGGAAGTTCCAGCTCATCAGAAGTGGACCC


CATCCACTCCCCTCGCCCCATGGAACTGGAAGTTGGACAGAGCACATCCAGGGACTCCAGTTGATGTCCCCTGTGGTTCAGGACTTG


GCATATCTGAAAGCAAAAGGCTGAGTCATGGCTCTTCCCCCCAGTCTGACCCCAGGGAAGTCATAGCAGCAGCTGTTTACCCTTTCC


CATCCTGCTTCCTCCCTCCTCACACACCCCCTCTACCCACCAGCCATTTCAAAGATTCCACAGTTAGCCAGGCCCTCGGTGATTTGT


CTCTTAAAACTAACCTGCATCACTGCCATGTGACACAGCACTGCCAGGCTGCCACTGTGGCCTGTCAGACTATTAACTCACCTAAGT


GAAAGGGCCCAGCATCCCAAAGGGGACCCAGGGGACAGGCAATCCTTATACCACTTGAAGATGGACACAGCAGGGTGGGATCCCTTG


GCACTTCCTTCATGTCCTCTAAAGGGCCAAAATGGACCATTGACTTCTGGCTCAAGCCTTAGGCTCCTTGTTCTTCCTTCCTCTCTC


AATCCCATCAGCCCATCATTTTTTCTTATTCTTCAGCCTCCTCCTTCTCTCTTTCCCCCCTTGACCCTTGCTGTTTAGGATGCAACG


CAACTTGTTCCCCATCTCATTTTCTGCCCAGCTTTACCTCTCCCTGCACCCACCTTCTCTTCTCTTCTCTTCTCTTTTCTCCTCTTC


TCTTCTCTTTTCTCCTCTCTCCTCCCCTCCCCTCCTGTTCTATTGTCTTCTCTCCCTTCTTCATTTTCCCGCCCCGCACCCCGCACA


GTCTGCAGAGGCTCAGCAGTCTAGGCTTCAGGATTCCTCCACCACTTTATGAAGGCTGCTGATGTCTGGCCCCATCTTTATTAGGTT


GCCTCTTAATGGAAAAGACCAGGTTAGGTGTCATTACTGGTGACTGCCCTAATTACATCCAGTCAATGGAAAAATGAAGCTGAGAGC


ATCCATTTAAGTTGGAATTAAGGGTTAAGAATGCAGCATCCTCTAGAGGAATACTCACAAGGGAGTCATAACATCTCTATGTTGAAA


GAAACTGGGAAGTGTCATCTAGTCCACTGTCCTGCCTCCAGAGAGAAATTTATCTTCATCATGTGAGACAGGTGGTTCATTAGATAA


AACACTCTAGCTTCTCATTAAAAGCCCCCCCTGCAATCAGCCAACTAAAATGTGGGCCATGGCAAGCGCTGTGAAACACCCCATCTA


GACCCTGGAAATTTGGAATGGTGGATGATTGATTGTTGTGATTACATTCCCAAAATAGCATGGAACAGGGAAGCTCCCTCTTCAGGC


CTATTGGACCCCAGCTTTCAGGGATGATTTAAGTAGAGTTTTGCCTGGGCCTAGCGAGAGGAGGGAGAATGGAACCTGGGGAGAACC


CTCTCCATCTGATGTTCCATTTTTAACGCTATGATATAGCCCTCTTTTTGGGCTTTCAGCCCAAAGTACTTTTGGAACTCCATATAA


AGGAGAGGGATGATACTCCGTCCGGTCGAGGGGAAGGGAGCACACATCTTCCCTCTAGGATGGCTTCTTTTAAGCTATTTTTTGCTT


TTGGAGGCATGGCTAAATTGATTACAGCTACAGACCAGGCTGTGCAACTGCCCAGATCCTTTGAAAATTGGGCACAGAGTCTCCTGT


AAGTCACAGAAGCTGAAAAAACACAGCCGTCCTCGAACAAAAGAGGAAAATGAGGTCAGAAAAGGAAAGTTCACACAGACTTCGTTC


TTTTCACTTTGTGACAAGGCCAACAAATGTACTGAGAAACACTAGATTGTTTTAATGGGGACCCTTGTGGGAAACGAGGAGAAAGCA


TTGTCAACTTCAACCACATTGAAACTTCACACAGGCTAGCCTTTGTCAGCCTGTGGGATAAAGAGAGAAATAGCTTCTAAAAGAGAG


AGTAGGGAATGGATCCACCCATATGCATTCCTTCCAAGTCGGTTATAGATTATAGTACCTTTGAAAAACATTCTTTTCTGCTTCTCA


CACATTTTGTAAGACCTGATGAGCCAAAAATGTTACTGACAGATTCCTTCCATTCTGGGACCTCAACTGCTAGACTGGGTTCTGTGG


CAACTAGAATTACTGTTTGACATACAGGATTCGGTTGTTGGCTTTAATAAGTTCATCATCTCTTTCCATGAGTGGTGGTCAGGGCGG


CGCAGGGCACAGCATGCAGGCAGAGGGCGATGGTCTCTGACGGGAGTCCGCTTGCAGAAGGATGGAGCTGACTCCCGCTGCCTGCCG


AAGAGCCAGGGGAGTAGTGAGTCTCTGAATTCCCCCTATGCTCACAAGCCAACCAAGAAGCCTAGCGAAGAGGATTTTAAAATGCAT


TGGGAGAATGTTGGAATGTGCAGGGAATTCCCTGCTTATTTCCCAGACAGTCAAGTATGCACCCAGAGGATTAGGAGAGAGAAAGTG


AGTCCCACCATTCTGGGGGCTCAGCAGAGCCTGCTTCCTTGCCCACCCTCCCCCGGGCTCCCCTGGCACGGACCTACCGAGCAGACT


AGGATCGCTGTTCCAGAAAATCCCAAGGGTCTGCTGCGGGCTCACTTAAAATCCCGGTTTTGATCCAGCAGAAGTGGTGTTGTCTTT


AAAATCTCTGCATGACGGTGAATTCATGAGCCTCCTGGTGAAGGCAGGAAGGAACCGATTCCTTGTGCTGAGTCATAGCGTAAACCT


TGAGGTGAAAAAGCCCAAGTGTAGAGCAGGCACAGTCACTGAGTGCACGTGTTCGTGCCAACCTGGGTGCCCTCTGTGAAACAAGCC


CTGGGGAAAGGTATTGCCTCTTCATTCGATTATTTTCAGGAACACTCTCAGCCACTGGCAGGTGTTCCATCTGCACCCCAGCTGATG


GCCTACCTTCTTTCCTCCCAGGCCTGCTGGTCTAGAGCTGGCAGTGGGATGGAGACCTGCCTGAGGGAGAGAGGGCCCGTGTGTGCT


GGCCCCTCTGTCTTCCGCTGCACAGCTTGGCAGCTGACCAGGTGCTTAGTTGTTGGTTAAACCCCCCAAAGCCTCGGCGCCACCCAG


CATCCTTCTCCATTGAAACTGGCTAGCTCAGCCTCCCAGAGGTCAGCTGCAGAGCACAACCCAAGAGGCACTGCAGACCCCTCTGTG


GGTCAGGACATCAGAGTCCTGACAGATTTCAACAGATTTTTGTGGCTTGGTCGTGACCAGCCAGAGAGCTCAAGTTCCCACTCCACT


CCCAGGAAATTACCCCCGTGGCCGCCAGGCGTGTTGAGTCTCTCATCTTGCCTCTTAATGATATGTTCTTTCCCCTCTGGTCCTCTT


GATGTCCCCCCGCAGGGTGCAGGCTGCACTGCCCTTGTGGTGGCCGTGGTGGCCCGAAAGCTGGAACTCACCAAAGCGGAGAAGCAC


GTTCATAACTTCATGATGGACACTCAGCTCACCAAGCGGGTAAGATGCCACACAGCCATGTCTTATGGGGGACTTAAGGCCACAGTG


GAAGCCAATCAGAAAGCAAATGGTCCAACGGGTGCAGTGGCTCACGCCTGTAATCCCAACACTTTAGGAGGCTGAGGAGGGTCGATC


ACAAGGTCAGGAGATCAAGACCATCCTGGCTAATACGTTGAAACCCCATCTCTACTAAAAATACAGAAAATTAGCTGGGCATGGTGG


CACACACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAAGAGAATTGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATC


GCACTACTGCACTCCAGCCTGGGTGACAGAGAGAGATTCCATCTCAAAAAAAAAAAAAAAAGAAGGAAGGAAGGAAGCAAATGGTCA


TGTCGTATGGGTTTGCACCAGGCTTTTAAAGGGTGTGTTTGAGGGAACCCCAGACACAAAATGGAAACAGCACCTTCATACGCCGGG


TTCCTGTCTTCTGTTCGATCACTGTGCATGGTTCAGGCCAGCCAAATATTTTCCTGGTAATTTAATTAATAGCCTACAATGGTATAA


CCTGCCCCTTTGCCTGATGATACCAAATAAATCACGGTATGAGGCAATGTTTTTTGTTTATGCTCAAATATTTTCAGGATTCTCATT


AGGAAGGGCAAAACTATATTGAAAATATACCTAAAACTATAAAAGTATATTGAAAATGTACCTAAGTCTAATCCTTTAAAAAAAATC


ATTTAAAGAATCATTCTATGCTGGGAGCGGCGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGAGCATGAGGT


CAAGAGATCGAGACCATCCTGGCCAACATGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGCAGTCACCT


GTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAAGCGGAGGTTGCAGTGAACCGAGATCGCGCCACTG


CACTCCAGCCTGGGCGACAGAGCAAGACTCCATCTCAAAAAAAAAAAAAAAGAATCATTCTAGTAGAGCCCACATCCCTAAATAAAA


TTGTTCATCAAAACATCATCATCCAATTTTTCCCTTTTGGGTTTTCCGGGTAATGTTTCTCACTTGAACCATTATGGAAGTGGTTAT


GGAAGATGAAAATCTGAAAATATGCAGGAATGGGTAGACCATTTAGCTGCTGAAAGTTGGACACCCCACTGAATTGTCTGAGATGAA


AAGACCCATTTAGAATAGACAGATACAAGCCTTCCAGAATAACAGCAGGCCAAATGGGCAAGGCAGGAGCTGTTTATTCAAGGACAG


CTTTTATCGAAAATTCTTTAGAACTACAGCCTGAAGGAAGGTCAGTAAGATGATTTCCTGCAAGACTGTCCTCTTTCTGAGACGAGA


CAGAATTAAAACCCTGTGCCCGTGTCTCGGCCTCCATAGTCTTTTTCATTTAGGACTGAAGTAGGTTAAGGGACCCATGAGCAACCA


AATTTTGATTTGGGTTTTTGAAAGCTAGAGAAAATATTCAGTGATTAATGTTGCACAGCAGCAAAAATGTGTTAGAAATAGAGACAA


CGGCAGGAAGGAAGAACAAAAAGAGAGAGAGAGAGAATGACAGAGGGAGCTGCGAGCGAGCTCTTGGGGAAGGCAGTGGGAGAGTGT


GCAGCGGCCAAGGCCTCTCCAGTTTCTCAGCAGAATTATTTATGGTGTTTGATTGTTTGGTCTTTGATTACATTTATTGGATTCTGT


AAAGAGCCTTAACAGACATTAAAAGGAACTGGTACGGGCAAATATTCTTATGTTGTTGACATTCAAGTGTTTGTACTTGATACATCA


TGGCCCTGAGCTATCAGCTGCACCAAAAAAAGCCATGATTTGTCACATCACGATGGCAGTGATTGAAGGCTGTTATCACAGTAAGGC


CTGCCGGGAACCCTGCCACTTGGCCACTCTCTTTCAGCCCCCTCTAATAATGGGTGCAAAAGTCATGCTCAGTATTGAGGAAATTAT


TCAAGTTATTGAAACACCTAAATGCAAATCCACTTGCATCTATTTTCCTGAAGCAATTTACTGAGGTTTCACTGGATTGAAACTACG


TGCCGGAGTGAGGGCAGGGAGATGTTTTGCCTCCAAAGCCTTCTCATAAGCTGTTTACCAAGAGTAGAGACATTAGCAGTCTCTCTG


TTTATTCTGGTTTTCTTTTTTAAGCCAAGAATATTCTTTGTATTTGGTGTTATTCCTTTGTCCTCTCCATTTTTCACCAAGTAGATC


AGACGCTAGAGGAAAATAAAGCTGAGGAAAGCCAGCTCCTTTGTATGCCAGGAAAATAAACAATTTTTCTGCAATATAATTGTAGAA


GATGAGACTGTGGTTGCTAATTTTAATCTTTCAAAAATGATTCCCTAACATCCTCCTCAATTCCACTTCTTGAAAAGTAGGACTGAA


AATCAAATCAACAAATATTTATTGCTCACCCATGAATCTAAGGTAGCTTTTTAATCGAATAACATCTCACTTTTCTGAGAACACTTA


AATCTGTTGAAATGTCTCTTTAATATCTAATATCTTTTCTCAAGGAAATAAACAACACAGAAGGGATGGTTCTTACAGAGAGAAGGT


TTTCAAAGCTGGCAGGACTAGAACTTCTGAAGGTTCTTTTACATAACCTTAATTGAAATGAAACTGGATGTGTGCATCCTTGGCCTG


CTCTGGTTTGAGCTGACTTTGACCTGCTCACAAGAGAACCCCACCTCTCTTCCCCTGGGGATGCCTGGCCTGCCTTCTGTCCTCTTG


AAATGGTCCATTGTATCAAGCTGGAGTGGCTCATTGGTCAAGAAGATGCTAAGCAGCCGGGTGCGGTGGCTCACGCCTGTAATCCCA


TCACTTTGGGAGGCCGAGGTGGGTGGATCATGAGGTCAGGAGTTCGAGACTAGCCTGACCAACATGGTGAAACCCTGACTCTACTAA


AAATACAAAAATTAGTGGGGCGTGGTGGCACACACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAATCTGG


GAGGCAGAGTTTACAGTGAGCCGAGATCCCACCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCTGTCAAAAAAAAGAAAAAAA


AAAAAAGAAATACTCACTCTCAGACATGATCCTTAGAAGCTCTTGGCCGGGCGCGGTGGCTCATGCCTGTAATGCCAGCACTCTGGG


AGGCCGAGGCAGATGGCTCAGGAGGTCAGGAGATTGAGACCTTCCTGGCTAACACAGTGAAACGCTGTCTCTACTAAAAAAAAATCC


AAAAAAATTAGCCGGGCGTAGTGGCACGTGCCTGTAGCCCCAGGTACTCGGGAGACTGAGGCAGGAGAATCGCTTCAACCTGGGAGG


CGAAAGTTGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGGCAACTGAGCGAGACTCCATCTCAAAAAAAAAAAAAAAAAA


ATGCTAAGCTCAGTCTATTCATAACATCTCAGTGAATTCTCAGAGAAAGATCCAACATGAAGGAGTTGACTGTGGCATAATTGCAAC


CTCTTCGGAGTGGGCAATTAGTAGATTTGACAGATAAAAGCAGTCTCTTACCGGTATATGCAACCTTGATGCTTCAAAGACCTACGC


AAAACGAAAAAAGGAATTGTAGCTATTAATCATAGAAAATACTCAAATTGTTCTAGTATTTATTCATCCTGTCTTGCTCTAAAGACT


GCAGCCTAGCCTTTGCCATGAGAGCCAGCACTATTTTTATTTATTTGTTTGTAGGGAGGGAAGAGGGTCTGATAGCACTGGGTAAGA


ACTCAATTTCTGCTTTTCTTGAGTCCCATGCTTATCTTCTTTCCTCGTATGACTTATCAACTCTGGTGGCAACGTCATTTCTGTATT


TAATTCAATCAGATCTTCCCACACTGACTTCGCAGTGTCACTGCCATTGTTATTCTGTAATTATAACTTATTGCTAATCTCTGGGCT


ACTAGATAATATTTAAGTACATGATTCACAGAGGGACTGGAAGAAAGATACTAGAGCCCCATCTTTTCTGCCACTTAGTGTTTTCAT


GTCCCCATCTTTCTGTTTTATGTAGCTAAACAGATCCATCACAGAGGCCACTCCCTGGGTGCCACACTCTGTACTCTGGGGGCACCA


AGATGGGTAAGAGGTGGTCCTCACCTCCATCCCTAACCTCTGGTGGCTGACTGCCCTCAGAGAGCACTTCTTCTTATAAGAGGTAGA


CTGGGCCGGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGCGAGGCCGACGTGGGCGGATCACTTGAGGTCAGGAGTTCAAGA


CTAGCCTGGCGAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCATGGTGGTGGGTGCCTGTAATCCCAGC


TTCTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGGCGGAGGTTACAGTGAGCTGAGATCGTGCCACTGCACTCCAGCCT


GGGTGACAGAGTGAGACTCCATCTCAAAAAAAAAAAAAAAAGGAAAGAAAAAGAAAAAAAAGGCAGAGTGGGCTGCTATGGACACAC


TTGGCTTGGGAGGCACCATGGACCGGAGATATTTTCTTTGCGGTACCTACTCTCCACATCAAGCCACAGTGAGCAGAACCTTCAGAC


AGCACAGTGTGCTAAGGATCCTATCTCCTTCTTGCTGCAGGGGTTTCTTGCCCCAAGTAGCTCACCCAAGTACACTTCCCCATGAAT


TCAATGAATAAGACCAAAATTAAACCCACAACTTCCCTAAACTATTTCCTTCTCCTAACTTCCCTGGTGTGCTCCTGACATCGTGTT


CTTCCAGACGCCAGGCCTAAAGACTTAGCCCCATTTCTGACTCCTCTGGACCCTGGACCCCACGAGGGTCTGAGCACTTTCTGTGTC


TGATTTCACCTTGCCGTGGCTGTTCACGCATGCCCGCCTCTCCAGGGCCTCGGCCCCGCCACTCTTGAAGCCGCCATCTTCTGTCTC


GCACTATCACAGCAGCCTGCTACCTGCTCTCCTCACTTCGGCGTCCCTTACCCCAGTCATCCTGCACTCTGCTTCCCCATGGATCTC


CTTAGACTCTCAGGCTTAGCTCTGAACAAATTACTTCCTGCTCAAAAACCTTTAAGTAGTTTCCCCACCTACTATCTCCTGAATGAC


ACTGAAGAAAACTTTTCTTTAATTACAAGCATATGCCAAAGTTTGATCATAATCTTGCTAGAAGAAAATTTTCTTCAGCAGGCTAAT


TCAAAGATTACTCTTAGTAGTGGTATTTCGTAGGAAAAACAATGGTAGTCATTGTTATGCCAGATTATAGAAGGTTTAGCTAAAGAC


TGCTAATGGACAGCTGGTTGGGCTCAACAGTGGATTTCCAGAACAAGTCTTCAAGTCTTTACAATGGATCAGATAATCAATAGGGCA


GTTATCAGGAATGCTAATTCTCCCCAGAAGAGGATTATAAATTACATCACGCACAAGGTTCTGTCCCAGACAGATTGGGTGCAGGTT


TTCTTTAGCAATAGTCACAGAAACAATGTGCGTTTAAGCTGGAAGGACCCTTAGGGAAGAGCCACTCCAACCCACATGAGAAGACGA


AGGCCCAGAAAGGGGCGAGGGTGGGCCCCCGGCCTATGCAAGATCCACTTTGCTCTCAGACCATCAGGCAGGCAGCTTTAGGGCGGT


CAGTTCCTTGGAACTCAGCATGGGGTTAGGGTCCCAGACCTGCTGAAAAGAAAAGCCAGCTTAACTCCACCCTAACTGAGTATCACA


TAAATAGCATTATAGAATTATCCACCACCCATTACCATATTGCTACAGGGAGAACCTCAAGCTCCAACTCTGAACAACGGAAATACA


CCTCCTCTCTCTCTACCCAATTTCCTGCCAGCCAGAGAGGTGGAGCTCCCAGTTCTAAGTGGTCAGTGAGGGCCTCTGGGTGAGGCA


GGCAGAGAAGCCTGTAAAGGGAGTGTGGAATAGAACAGGGGGAGGAAAAAGAGGAGGTGCAAGCAGGGTGATGAAAGAGAGGGCAGC


CGGGGAAGCCAGAGCAAGTCTGCAGGGTGGTGATGAGGGGAGAGTGGGCTTGGCAAATGGGAAAGAGGAACCAGCCCCCTTCTCTAG


TCCTGTGTGTAATGGACACCTTCAGTCAAGGGCTGGCTTGCAGGTTCTCCGATAGTGATCTGATCATCACTCAGCCTAATTTCAACC


TGTGTAACTCCTTGAAGTTACAGTCATGCACTGCATAACAAGTTTCAGTCAATGATGGTGCACATATACCAAGGTGGTCTCAGAAGG


CTATAACAGAGCTGAAAAATTCCTCTCCCCTAGTGATTTGTGTTACAGTGGCCTACAGTACAGGAATGTGCCATACAGGCTTGTAGC


CTAGGAGCGATAGGCTATACCATACAGCCTAGCTGTGTAGTAGGCTGTCCCATCTAGGTTTGTTTAAGTACACTCTGTGATGTTCAC


ACACTGAAGAAATTGTCCAAGATGTGTGTATTTAAATCACACCCACCGGCCAGGCCTCCCTTTCCCCGTCTCCAACCTCCAAGTAGA


ATACTTCCCTGGCAAGGGTTCCTGGCAGCATAATGGGCATGCTAGTGATTTCTTCTCTGGGGGGCTCTGCTAATGCGACCCCTGGAA


TTTCCCAGGGCTCCTGGGGCTGCTGGAGGCTTAGGGTGCCCAAGAAAGGTGCTCCTTTCATCCCCCTTGTACTCCTGCCCCAAGCAT


TCTTGCCGCAACCGACAGCCCCTCTGTAATAGCAAGTAGCAGGTTACCTGGGCAGAGAGGTGGCCAGAGCAAGTCATTGACATGGGA


TGCTGCGGCCAAGAGCTCAAGGAAGAGGTGTGTGTTCTGTTGTATGTTTTCTTGCTGGCTGGGGAAGTTAGAGGGAAGGAAGCTGAC


ATTTATTGGAAGGAGAGAATATTAACAAAGGTACCATGTATTGAGGCATATGGCCAGGATCTGTGCTAATGTTTTAAGTATATTCTC


ATTTAATCAACACAGTAATCCCATTTCACAGATGCAGGTAGTACTTGCATCACTCTCTAGCCCTGGACCCTGCTTTGTTGTTGTGGT


TTTTTAAGCGCTTGTTACCTGATGCTATCATACAAACTGCATACCGTCTTCTCCGCAGGATTGTAAGTTCCGTAAGCGCAGCAATGT


TATTGATTTGTTCACTGTGGTACCGTCACTTGCTACAACAATGTCTGGCCCATCATAGGTGCTCATTAATTGTTCCTCAAATGTATG


AACAAAGAGAGTCTCAGAGAGTTCAGCAGTGGGTCCAAGGTGGAGCTGATGATCACGTCTATTTATCAAGTTTTTCTGAGGGTTAAT


GAACCAGTGCAGACATATGTGCTTAGCACAAAGCCTGGCACGTAGTAAGCACTCAGTATATGTTAGCTGTCACCATAATTTGCAAGG


TCTTCATTGGACCACTTTCTTGCCCAGGCCCATTAATCTTAGAGCCTTTCCTAAAGTAGATCATAGAGCCCATTGTCTGGCCCCAAT


CAGAGTGAAAGCAATTTTTTGGTAGAGAGTTTTTGGGCTTGCAGAAAACAATCAGCCAATTTGTTTATGGGTTTTGGAGGCAGGACA


GCTGGACTTCCATTCACAAAGGGTCCTCTCCTAACCATCCCCAAACCCATCCGATTGTGGCCAACCTTGAGCCACTCTTTCTGGCTT


GCTGCTTTCATCTTAAGCCCTGCCCTCTCGCACTGCTGCACCCTGAGAGCATCTTTTGGCCCTGGTGCCTCTGCCCACCAGGAGAGG


TCAGGTGGTACCCAAGCCTCCCTCAAGGAAGGGTGCATGGAGCCCTTTGGAGGCTCGGCAAATCTGAGGAAGGGCACATGACCTCAT


GTGCTCCCGACCCCAACAATGCTTAGATCAATCAGCCAGGTGAACTGGAGGGAGACCCTGGCCACAATAGCATTTACTGTCCACCTG


GGAAAGCACAGTGCAGTTAAAAGCCTATTTCTTTTTCTCTCGCAGATATTGATCTACTTAGCTTTGTGCCAGGCTGTTTGCTGGTAA


TTAATTTCAGAGTCAGTGCAAGGGCTGGCAGTTAACATCACTTTCCCGAATGCACGGAGGCCTCCCTCCAAACTCATAAAGATGATG


TGACTGCCTCTCTCAGCTACCCGGGCCGTGCTGTGACTTCAGTATCTTACATTTGGGCTGACGTTAAGTGCAGGACCTGGACTCCGT


GTTCTGTCACATTGCTAAGTGAGGGCCATGATGATTTAAAAAAAAAAAAAATCCAGTGCTCTTTCCAGTTCCTTGATCCTGGAAAAC


AGGAAATGATTTTGTTTGTCTTTCCTTCAGTCCACATGAAAACCTTCTGCTCTTCCTGGACGTGGCTCTTGTTTTGACTTTGCCATT


AGCTAGCTGTGTGATTCTGGCTCTCACATCCCATCTCTGAAGTGGTTTCCTCGTATGTTCAATGAGGGGTTTGAGCTAGATAATATT


AACTAATATCTGTATGGTACTTTACATTTTATGTAGCATTCACACCCACACTGACTCAGTTTGCCATTAATAATTGTCTAGTCTTGG


TCTGTGTCTTGGTTTCTTCATCTGTAAAATGTGGATAATGTTAGCACCTCCCTGATGGGGTTGTGGTGAGGATTAAAGGAGCTTAGA


CATATGAAGTACTCAGACCTGTGGCTGCACCTGGTAGATGTTAAGTGTTGCCCCCAGCACCATCATCACTGCCTCATAGCAGCCCTC


TTTATTTTTCCCATCTTACAGATAATGAAGCATTTGCTCCTAAACTGCTTAATAATTGACAGAGCAGGGATTCACCTGCAGACTTTC


CAGTTTCCTTGAGGCTTTCCTAAGAGGCTAAGTGCGTAGGGAAACTGAAGAAATGACACATCCAATTGCCTCCTCTCCCTGCAAGAG


GAGGGCAGTAGTATTAAATGTGTGCTCTGCAGAGAGCAAGGCTTCCCTTCCGTGCCGCCTTTTTTGCCAGGAGGCTGCTGTTCACTC


TAGTTCCCTGAGCAGAAGCCCAGAGACCACAGTGTCCTCTCCTGGACATCCACCGTTTCCAACTTTCCACCACAACCTGCTTCCTTT


CAGGCAAGAAAGTACTAGAGGTGGGCAGTTAAGTCATTTAAAACTATTTTCACAGCAGATCTTTACTGAATTTTTAAAAAGCAATAT


TTATGTCCCTTAGACATTTCTGAGAAGACTTAGCTGTTCTTTTAAAAACATCACTTCAGCGCCAATGAAAAATATAATCCAGCCTTA


GTAATAAATTTTTAAAACATACACACACAAAAGTTATCAGCCTGCAAAACAATGTTTCCTAGGCTTCCCACACATCTCAGTATTTTA


ACAACATCCCATCTGTTGATGTCAGTCTGAAGAAGCAGGTCTATATTCTCTAATTTTATTAAAATCCTTTCTGGCTAGTAACCTGAT


TTCTATTAGGCTGGCCTACTTATTTCCAGGCCCCAGGCCTGTGGACACATGCCAGTCTGCATGGCTGACAGAAATGGGGATGGTTAA


TCAAAAATCTGCTTAGCATGTGCTTAATAAGGAATGTTTTCTGTTGCTCTTGTTACTAATTGCTGAAGATGTCTGTGTTTGGATTAA


AACTTTGTCCCCTGCCATCTGGATGCCATTGATATGTCTCAGCTCAGTCATGAGCCTGGTGATATCAGTGGTTTCCATGTCAATGGA


TGACAGCGTCATATGTTGAAACGTGTGATTGCAGTGCACAGTGAAGGAGCCAGCCCTGGGGAAGAGGAAGCTCTGGTTTCACACCTA


AATATCTTCACTGATTTTCAGACATTGCTCTGAAATTATTTCTTTTTTGTGCCAATTACATTTACATGTACAATTGCAGTGCAAATG


TTTTTGGCCATTTGGGAAAGGAGACAATGGGCTCGTTGGTACCTATAGTTCCAATCAGTGGGAAAGACATTTTCTCAAAGAAGTCTT


TTAAAATCTCCAGCTGATAGGAAATCTGTTTACTCTCTGAACCCAAGCAATGTACCGTATACACGAAGTGGCAATCTCAGGCAAAGC


TCGGAAGTCTGCATGTAAGGGCAGCAATGGTATATCGCTAGCTATTTTCCAAGGGGACCCCGGGACTCAAGGTCTCGCTCATGCAGC


CTGTCTAAATATAGCATCAGCAACAGCAGTCAAGAGATAGTATTGAAATAATCAAGAAGGAAGAAAGAAAGAAGGAAGGAAGGAAGG


AGAAAGAAAGAGAGAAAGAAAGAAAAAGAAAGAAAGAAAGGAAGAAAGAAAGAGAAAGAAAGAAAGAAAGACCCTCCAACTTCAAGC


TCTGGTCTGCAGTGTCCAACACAAGATTAAGAACAGATGAATTTTAATCACCTTTTTTTTTCCTTTTTTTTTTTTTTTTTGAGATGG


AGTTTCACTCTTGTTGCCAAGGCTGGAGTATGGCGTGATCTCAGCTCACAGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCTTGC


CTCAGTCTCCAAAGTAGCTGGTACTACAGGCATGTGCCACCATACCTGGCTAAGTTTGTATTTTTTGTAGAGACGGGTTTCACCATG


TTGTCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCGGCCTCCCAAAGTTCTGAGATTACAGGCGGGAGCCACC


GTGCCCGGCCTTAATCATCTTTTCTAGGAGTTCCGTGATTTTCGTTAAGAAAATAGATCATTGCAAAATCGTTTCCTTATGAGGTAG


ACTACAGTAGCAACCACAAAAATGAACCTAAGAAAATGAACCTGATAGCAGCCTACTTTATTTATTCTTCCTTAGATCAAGAATGCT


GCAGCCAATGTCCTTCGGGAAACATGGTTAATCTATAAACACACAAAGCTGCTAAAGAAGATTGACCATGCCAAAGTGAGGAAACAC


CAGAGGAAGTTCCTCCAAGCTATCCACCAGTGAGTATGCCAGAGCGGTTCAGCCATCAGATGACCAGACTGGGAGTGGCGGGACTCC


TACAACTCTGTCAGTAGCACAGAAGAAATCCATTCTGTTCCACTCAACAAGTGGAGTGGTGAACTGGGTCTGATCACTCACTGACTG


CACCAGCCACATGCCAGGAATTGGGCAGGCTGCTATGGAAGGTAAAAACTAGAGTAACAACCTCTAAGAGCTTTCACATTCTACACA


CACACACACACACACACACACACACACACACACACACCATGCATTGCAACTCAAATCAAAACAAACCGTGGCTGATGCTTTCTGTGA


TGGAGGAGTTTTTAAAAGTATAGTGGAAAAGCAAAGGATGAAAACATTCATTCTGATGGAGAGGTTTGGGGAATCCCTGAAAAGTTG


AGAATAAGGCACTCAACATGGAAGGTGCAGCCCAGGCATAGAGGCAGGGAAATGATCTGGGAATAGCAAGAAACCAGTGACTGAAGG


TGAGCATGCGTGGAGACAAGAGTTTGCTTTCTGGGGGGATGTGACAAGCCCCTGGAAAGTAAAAGCCTCAGTTGTTCCCCAGGTTCA


CGGTCCCCATGCTGGGTTCCAAAATCAGAGGCAGTGGTAGGGCTGGAGGATCTGCTGGTGGGGCTAAACCTTTGCATGGACTTGAAG


GGCTTGCCTGTTACCATTCTTCCCCACAGGTTGAGGAGCGTCAAGATGGAACAGAGGAAGCTGAGTGACCAAGCCAACACTCTGGTG


GACCTTTCCAAGGTGAGTGGCAGTGTCTGGAGACATCCCCTAGAACACGCAGACACTGAGTCTTCTCAGGCTCACCTGTGAGTCCTG


GCTGGGTTCGCACTGGACAGCGCGGGACCAGGCAAGCAAAGAAAAATTTCTGCTTGGTTCAAAAATACCTAGGCTCAAGTTTGTTTC


ATTTGCAATCTACCGGTATGTCTTGTGGGCTTTTGAAACTTGGTGTTTGTTTCTTAAGTGAAATCGCTCAGGTGTGTCTCTGCGTGA


AATTAATGAGCTGACTAAACCTTTTCCGTGTCATTTTATGAGCTGCACATTGAGGGACTCCTGAGGTTGGGCTTGAGTTTGCACGGC


TGTGAAGCATGCTAGCAAGGACCAGACGGTAACGATGGCCATGGTAACTGCCCAGGTCACACCGGTTTGCTGTAATACTTGGAAGTT


CATTTTTGTACATCCTCCAGTCCTTAACCAACTAGTTTTGCTGGCCTCAAATTGGCGGCAGTGGTGTGTGTGGGGGGGTGCATTTCT


TTACTTCTCAAGAGGCAGATAGCCTACAAGGAACATGAAGATACCCAAAAAGAGAGCCCTCTTTTGAGAGCCCTAGGGTGTAAGGCT


CGCCATCACTCTGCCACTCTGTTTCTGGCCCTGAGCTGCCATAAATACTGTAAGGAAACTCCTCTTGCAAATCACCCAGGTGAGGGA


GCCGAAGGCCACACTGCTGGCAGAGCTGAGAGTCGGTGCCACTGAAGAAAGGGCCTCCCCCTCCTCAGCCCCCTCTCCTCATTGCCT


CTTGATAGGAATTGTATATTAAGTGTACAGCCCAGGGCCAGGCTGGCAGAACATTCCAGCAGATGTCAATTATCATAATGGAACACA


TTCCCTGGGTAAGCAAGAGAAACTCCCTCAGGCACATTAAGCACCCTTTGAAAAGAGTGCAATCAGAGAAATCACTAGTTGTCGGGC


CACGTGCAGGTGCCTTGTTTAATAAAGGGATTGAACCAAAGAAAGGGCCTTCTAAACCTGTGAGGACTTCAATCGGGGAGTAAGTGG


CTTGGCACATTTGGGGAGAAGCCTCCAGGCCCGCGTGCCTTTGGAGGAGGGCGTTCACGTGGAGTGCAGGGTGGTTCCTAGGAGCCT


GGGGTGGGAGTGGAACGTGGGCATGCAGGAGAGAACTCCCTCAGGTTTTTGGGTGTGTTGGTTTTAATATCAGAAACCCGCTGGGAC


TAGGTTTAAAAATGGAGAAATCTATTCTAAGGATATAAGGGAGTCTCATTCCAGGCAAAACCTCAAAGGAGACATGTGGCCAGACTG


CAGGAAGGAACTGACTCGAACTAGACCTGGGAAGCCCCCACAACCAGGAGGTCTCTCACCATTTCTTCTCTGTCCTTCTGTTTAAGT


GACTGCTTCAGTTCTCTCTCCCTCTCCCTGTCTCTCTCTTCCTCTCCCTTTCCCTGTCTCTCTCTTCCTCTCCGTCTCCCTGTCTCT


CTTCCTCTCCGTCTCCCTGTCTCTCTCTTCCTCTCCCTTTCCCTGTCTCTCTCTTCCTCTCCCTTTCCCTGTCTCTCTCTTCCTCTC


CCTCTCTCTTCCTCTCTTTCTCTCCCTCTCTGCCTCCTGTCCCCGCGACAGACTGTAACAGGCTCCAATTCAGAGAGTACATATAAT


AGTTTTAGCCACAGGTAAAGACTAATTGGCCCCCTACTAGTCTTAATTCTAAATTCTCAGAATAGAAGAAATGATTGGCCAATTTGG


GCCACGTATCCACCCTGGGACCAATCAGCATTGGCCAGGAAGAGGGTCATATGGAGCAAACAGGGCTAGGGGCCCACCTGTGAGCTT


CAGGAATAGCCCAACAAACTGCCCCAGGATGTTTCTTCCATGAGTAGCAGTATTTCCTGTTTCTCCTCTCACCTTGCAGGACATGCT


GTGACTGATGTTCCCTGGGGACATGAGGCAAACCAAACTTTCTTTTTTTTTTTTTTAGTTTTATTATTATTACACTTTAAGTTTTAG


GGTACATGTGCACAATGTGCAGGTTTGTTACATATGTATACATGTGCCATGTTGGTGTGCTGCACCCATTAACTCGTCATTTAACAT


TAGGTATATCTCCTAATGCTATCCCTCCCCCCTCCCCCCACCCCACAACAGTCCCTGGAGTGTGATGTTCCCCTTCCTGTGTCCATG


TGTTCTCATTGTTCAATTCCCACCTATGAGTGAGAACATGCGGTGTTTGGTTTTTTGTCCTTGCGATAGTTTGCTGAGAATGATGGT


TTCCAGTTTCATCCATGTCCCTACAAAGGACATGAACTCATCATTTTTTATGGCTGCATAGTATTCCATGGTGTATATGTGCCACAT


TTTCTTAATCCAGTCTATCATTGTCAGACATTTGGGTTGGTTCCAAGTCTTTGCTATTGTGAATAGTGCCACAATAAACATACGTGT


GCATGTGTCTTTACAGCAGCATGATTTATAATCCTCTGGGTATATACCCAGTAATGGGATGGCTGGGTCAAATGGTGTTTCTAGTTC


TAGATCCCTGAGGAATCTCCACACTGACTTCCACAATGGTTGAACTAGTTTACAGTCCCACCAACAGTGTAAAAGTGTTCCTATTTC


TCCACATCCTCTCCAGCACCTGTTGTTTCCTGACTTTTTAATGATTGCCATTCTAACTGGTATGAGATGGTATCTCATTGTGGTTTT


GATTTGCATTTCTCTGATGGCCAGTGATCATGAGCATTTTTTCATGTGTTTTTTGGCTGCATAAATGTCTTCTTTTGAGAAGTGTCT


GTTCATATCCTTCGCCCACTTTTGGGCAAACCAAACTTTCAAGCCTGCATTTCTGCAGTGCCACCCACGGCCTCTTGGAGAGATGGG


GCCCACGGAGCAGACCGGGTGAAGCGAACCCCTCAGTGAACTGGAAAGACACTCCTGTGAATTGGGTGGGGGAACTAAGCCGTAAAT


AACCCAGGAGCAAGTTACCTGGAAAGAAAGAGTGTGCAGGAAAGGGTTAAGGGAAAAATCTGCAGAACCCCCGTGGGGACATCTGGG


GAGGAGATGAACTCTGACATTCGCCCAGTCTTTGTCTTTTCCTCCCAGGAGACTCACCCAAGGTCCTGGCAGCAGCTTAGCACACTT


CACACTGGTCCATATTCCCCCTGGCATCCTGTCACCAAGCAACGGAACAGGGGGAGACAATAACGCTGTGTTCTCTCTCTTTTCTGT


CTTTGTGCTGTAGCCTCCCAAGTCAGCGCCTTCCCACTCCTGCCCTTTGGTCCTCTCTAAATTAAGAATATGGCATGTGGCCTCCAC


ATATTACGTCTGTATTGAATTGCTGTCCTATAGGCTGGCAGAGCTGGGAGGGCTTGGAGTCTTTCCCCGATTGCTTCAATTACTTCA


ATTCAAATATAAAAATAATTCCTACCATCGGAGGCTCAGGTGATCGAATAAGATGATATCTGTGAAAATGCTTTGTAAACTATAAAG


GTTTTGCAATTGGTAGTTCTGATTATCAATATAGATGAGGAAACCAAGATCCAAGGGAACAAAGTGACCATCCCACGGTCAGGCAGT


TGGTGAGCACCAGCGTGGGGGCCACAACCCAGGGGCCTGGACTCTGAGTCCAGAGCTCATCAGGGTGCCCCTGCGGTCAAATGAAAT


GGGTGATTTTGCACATTCCGGGAAGAATGTTTGCCTCGAGGAGGTTCTGTCATGTTGATTAATAAAGGGAGTACTTTCACTTCTAAA


GTCACCCTGTCCTCCAAGGGCATCCACGACACGGTGTCCTGCTCTGGCAACAGCAGAGCTCATGGGAGCGGGGCCATCTCCATGCCA


CCTTGTGACCTTTCCTTATGCTGCCCCAGTGAATTTCCTCATGGGGCCTGTAGTCTGCTGGGGAGGCCTCACTGCATTTTGTGCCCC


TGCTCCCCTTCATTCTTCTCTGGCTTCTCACATCTTCTTTTACTCTTCTTTTTTCCTCTCACCTTACTTGCTGCTGCTTTGGTCCCT


GGGGCATAAATCATGTCCATATCTTCCTAGAGTAACCTGAAATTTCACGTGAAATAGGATCGGGGTGTCACTGGCAGATCATCAGAA


ACCCAAAGAGCCACAGTACCTCAGGGATGACCAAGCAACCACCGGCCTGGCCCTCTGCATTGCCGCCCCAGGAGCCTCACTCCCTGA


CACGTGGGAGGCTGAAGATGCTTGTGAATCTTGTTCCCAAGTCTGATGTACACAGCCAAGATGGCATTTGCTAATTTGCTGGGAGAA


AAATATCTGTTGCATAGACTGGGACTCTGCAGACCAACAAGGGGGCCACAGGATGTTGGGGAAGGAGCACTGGTAATCGGCCGGCAC


CCCTGGAACACGGGGAGTCAGTGCTGAGTGCAGGAGGGGTACTGGGGAGCTCTCAGGGGAGCACCCTCAGGACCCCTGCCAAGGAGT


GAGGGAAGCAGGATTGGTCAGTGGGAGGGTTTGAACTGTGATACAGTCAACAAAGACCTCAGCCCTTCAGAGTGGCCCTTCAGGGAT


GTCCCACCCTGAGGCATTGTGGATCAGGCAGGCGAAGGGCCACACCTCAGCAAGGCAGCCTCCTTTGGCTAAGCACTGTGCCTGAGA


GTTAATTCACTTTACATCCTGTCTGCTGGGTTAAAATAGAGGTTGGGAGATGTGCAATAACTCCTAACTGTGTACAGTTATTATTAA


CTCCAATTTTATAAGGCAACCGAGATTGAGAGAGGCCAGGCGCCTGGCAGAGGGCACACTGTTAGTGAGCTGCAGATGTGTACTTGA


GCCCTGGCCTACTAATTATACACCCACTGCACTGTCCATTCCCCACCAGCGTCTTCTCTGGAATCATTAGATGCCAGCAGCCATGTG


AGCTGAGAGGTTGTGGCCCTGTGAGAACATGAGACAGTTTAGAGACTCACTTTATTTAAGAAAAAAAAAAGGGCCATTTTTTTCCCC


TTGGTGCATATTTTCTAATAAAATGCTGTCATTAATACTCATTACTTTTGTAATAAGAAAACAAAAATGTGCACACTTCAGCATCCC


CATCCCCAGGAAAGAAGCCTGTATCCTTCCTTGACCAGATCAGCTGGTGTGGAAGTGGCTCCTGTCATACTGTGGAGGGCGTTTCAT


TTCTCCCATTGCAGATTCCTCTGTGATGACCTGTCATCTCCCTGTCTCTCGCCTCTCTCTCTCCACACAGATGCAGAATGTCATGTA


TGACTTAATCACAGAACTCAATGACCGGAGCGAAGACCTGGAGAAGCAGATTGGCAGCCTGGAGTCGAAGCTGGAGCATCTCACCGC


CAGCTTCAACTCCCTGCCGCTGCTCATCGCCGACACCCTGCGCCAGCAGCAGCAGCAGCTCCTGTCTGCCATCATCGAGGCCCGGGG


TGTCAGCGTGGCAGTGGGCACCACCCACACCCCAATCTCCGATAGCCCCATTCGGGTCAGCTCCACCTCCTTCCCGACCCCGTACAC


AAGTTCAAGCAGTTGCTAAATAAATCTCCCCACTCCAGAAGCATTACCCATAGGTCTTAAGATGCAAATCAACTCTCTCCTGGTCGC


TTTGCCATCAAGAAACATTCAGACCAGGGAACGGAAAGAAGAGAGACCGAGCTAATTAACTAACTCATGTTCATTCAGCGTGCTTGG


TCCGACATGCCTTGAAACCAGAAATCTAATCTCTGTTTAGGTGCCTCTACTTGGGAGCGGGAAGAGGAGATGACAGGAAGCGACGCC


TCTGGCAGGGCCCTTGCTGCAGAGTTGGTGGAGAACAGAAATCCACGCTCAATCTCAGGTCTTCACGCGGGGGGTGGGGGTCAGATG


CACTGAAGTAGCCAACAGCGAAGCCAGTCCAGAAGAGGGGTCCGCTGGGAGGGAGGGTTGTGTCAGGCTTGGGGGATGGGCTCTTCG


CCATGGGGGTCTTTGAACACACCTCTCTCCTTTCCTTTTGTCTACGGAAGCCTCTGGGTGACAAAAGTAAAAGAGAGCTGCCCACAA


CTTGCCAAAACAGATATACTCGACTCAGACTGAAAAAAAAAAAAAAA





HUMAN mRNA SEQUENCE:hR27-009.1 (Seq ID NO: 27)


CTTACAATGTAACAGTGGCAGGAGGAGGCGAGCGAAGCTATTGAGCCAGCGAGGAGTGAAGCTGAGCCTGGCCTCACACGCTCCTAG


AGGACCACCTCCTGAGAGAGTTCTTTCACCCCCTCTTCTTTCTCCAAGCTCCCCTCCTGCTCTCCCTCCCTGCCCAATACAATGCAT


TCTTGAGTGGCAGCGTCTGGACTCCAGGCAGCCCCAGAGAACCGAAGCAAGCCAAAGAGAGGACTGGAGCCAAGATACTGGTGGGGG


AGATTGGATGCCTGGCTTTCTTTGAGGACATCTTTGGAGCGAGGGTGGCTTTGGGGTGGGGGCTTGTGCTGCAGGGAATACAGCCAG


GCCCCAAGATGGACACTTCTGGGCACTTCCATGACTCGGGGGTGGGGGACTTGGATGAAGACCCCAAGTGCCCCTGTCCATCCTCTG


GGGATGAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCCACCACCGCCAGCGCCACCAGCAGCCCCCCAGCAGCCCCTGG


GACCCTCGCTGCAGCCTCAGCCTCCGCAGCTTCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGC


CACCGCATCCCCTGTCTCAGCTCGCCCAACTCCAGAGCCAGCCCGTCCACCCTGGCCTGCTGCACTCCTCTCCCACCGCTTTCAGGG


CCCCCCCTTCGTCCAACTCCACCGCCATCCTCCACCCTTCCTCCAGGCAAGGCAGCCAGCTCAATCTCAATGACCACTTGCTTGGCC


ACTCTCCAAGTTCCACAGCTACAAGTGGGCCTGGCGGAGGCAGCCGGCACCGACAGGCCAGCCCCCTGGTGCACCGGCGGGACAGCA


ACCCCTTCACGGAGATCGCCATGAGCTCCTGCAAGTATAGCGGTGGGGTCATGAAGCCCCTCAGCCGCCTCAGCGCCTCCCGGAGGA


ACCTCATCGAGGCCGAGACTGAGGGCCAACCCCTCCAGCTTTTCAGCCCTAGCAACCCCCCGGAGATCGTCATCTCCTCCCGGGAGG


ACAACCATGCCCACCAGACCCTGCTCCATCACCCTAATGCCACCCACAACCACCAGCATGCCGGCACCACCGCCAGCAGCACCACCT


TCCCCAAAGCCAACAAGCGGAAAAACCAAAACATTGGCTATAAGCTGGGACACAGCAGGGCCCTGTTTGAAAAGAGAAAGCGACTGA


GTGACTATGCTCTGATTTTTGGGATGTTTGGAATTGTTGTTATGGTGATAGAGACCGAGCTCTCTTGGGGTTTGTACTCAAAGGTAG


GGGCTGTGGTTTCTCTTTATACCTTGAACAAAAGGAATATGTAGGTAGCAAGAGAGGGATTGAGAGAGGGGGATTGTGAGAGAGAGA


GATTGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGGAGACTGGGAGAGAGAGGTGGTGGTGGTGGTGAGAGGCGCTTGCTCAGTTAT


ATTCAACACTCTAACTTCCCGTGGTTTTCCTTCTTGATCCCGGGAGAATTCATTCCTAGCTTCCTCTGGGGGGTAGGGGACATCCCC


ACACACTGTGTCTAATTTGCAGACTCTCTGTTAGGGAGGATTCAATAATCCCTTCTGAGAAATCGCTTTTCCTCCTGGCTCACTCGT


ACTAAAGCATAACCCAGCAGCTTAACGCACCAATTAATTACACTCCGCCTTCATGTGTTTGCCACTTCCTGCGACTTCCCCTTCTTT


CCTCCCCTCCCTGCTCCACTCCATTTTCCTGAGGATAAAAAAGAAATAAATGTCTGGGTGGGGGGTGGGGATTCCGTACCATTGCCC


AAGTCCCTTCTCTCCCTGTCTTCTCCATCTCTTCCCAAGTTTCTGTTTCCCTCCTCTTCTCAGAGAGTCTCGGGCAAAATAGAAAAC


CATCCATGACCTGGGTCTCCTGAGGGCATGGGGTAAAAATATAGGTGGAGGAAATCAGTGGTCCTTTCCCTCAGGAGAGAGGACTCA


GAATAAACCTGCTGCTGCTTCGT





HUMAN PROTEIN SEQUENCE:hP27-009.1 (Seq ID No: 28)


MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQQQQQPPH


PLSQLAQLQSQPVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPF


TEIAMSSCKYSGGVMKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTASSTTFPK


ANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKVGAVVSLYTLNKRNM*





HUMAN mRNA SEQUENCE:hR27-009.2 (Seq ID No: 29)


GCCTCACACGCTCCTAGAGGACCACCTCCTGAGAGAGTTCTTTCACCCCCTCTTCTTTCTCCAAGCTCCCCTCCTGCTCTCCCTCCC


TGCCCAATACAATGCATTCTTGAGTGGCAGCGTCTGGACTCCAGGCAGCCCCAGAGAACCGAAGCAAGCCAAAGAGAGGACTGGAGC


CAAGATACTGGTGGGGGAGATTGGATGCCTGGCTTTCTTTGAGGACATCTTTGGAGCGAGGGTGGCTTTGGGGTGGGGGCTTGTGCT


GCAGCGAATACAGCCAGGCCCCAAGATGGACACTTCTGGGCACTTCCATGACTCGGGGGTGGGGGACTTGGATGAAGACCCCAAGTG


CCCCTGTCCATCCTCTGGGGATGAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCCACCACCGCCAGCGCCACCAGCAGC


CCCCCAGCAGCCCCTGGGACCCTCGCTGCAGCCTCAGCCTCCGCAGCTTCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCA


GCAGCAGCAGCAGCAGCCACCGCATCCCCTGTCTCAGCTCGCCCAACTCCAGAGCCAGCCCGTCCACCCTGGCCTGCTGCACTCCTC


TCCCACCGCTTTCAGGGCCCCCCCTTCGTCCAACTCCACCGCCATCCTCCACCCTTCCTCCAGGCAAGGCAGCCAGCTCAATCTCAA


TGACCACTTGCTTGGCCACTCTCCAAGTTCCACAGCTACAAGTGGGCCTGGCGGAGGCAGCCGGCACCGACAGGCCAGCCCCCTGGT


GCACCGGCGGGACAGCAACCCCTTCACGGAGATCGCCATGAGCTCCTGCAAGTATAGCGGTGGGGTCATGAAGCCCCTCAGCCGCCT


CAGCGCCTCCCGGAGGAACCTCATCGAGGCCGAGACTGAGGGCCAACCCCTCCAGCTTTTCAGCCCTAGCAACCCCCCGGAGATCGT


CATCTCCTCCCGGGAGGACAACCATGCCCACCAGACCCTGCTCCATCACCCTAATGCCACCCACAACCACCAGCATGCCGGCACCAC


CGCCAGCAGCACCACCTTCCCCAAAGCCAACAAGCGGAAAAACCAAAACATTGGCTATAAGCTGGGACACAGGAGGGCCCTGTTTGA


AAAGAGAAAGCGACTGAGTGACTATGCTCTGATTTTTGGGATGTTTGGAATTGTTGTTATGGTGATAGAGACCGAGCTCTCTTGGGG


TTTGTACTCAAAGGACTCCATGTTTTCGTTGGCCCTGAAATGCCTTATCAGTCTGTCCACCATCATCCTTTTGGGCTTGATCATCGC


CTACCACACACGTGAAGTCCAGCTCTTCGTGATCGACAACGGCGCGGATGACTGGCGGATAGCCATGACCTACGAGCGCATCCTCTA


CATCAGCCTGGAGATGCTGGTGTGCGCCATCCACCCCATTCCTGGCGAGTACAAGTTCTTCTGGACGGCACGCCTGGCCTTCTCCTA


CACACCCTCCCGGGCGGAGGCCGATGTGGACATCATCCTGTCTATCCCCATGTTCCTGCGCCTGTACCTGATCGCCCGAGTCATGCT


GCTGCACAGCAAGCTCTTCACCGATGCCTCGTCCCGCAGCATCGGGGCCCTCAACAAGATCAACTTCAACACCCGCTTTGTCATGAA


GACGCTCATGACCATCTGCCCTGGCACTGTGCTGCTCGTGTTCAGCATCTCTCTGTGGATCATTGCTGCCTGGACCGTCCGTGTCTG


TGAAAGGTACCATGACCAGCAGGACGTAACTAGTAACTTTCTGGGTGCCATGTGGCTCATCTCCATCACATTCCTTTCCATTGGTTA


TGGGGACATGGTGCCCCACACATACTGTGGGAAAGGTGTCTGTCTCCTCACTGGCATCATGGGTGCAGGCTGCACTGCCCTTGTGGT


GGCCGTGGTGGCCCGAAAGCTGGAACTCACCAAAGCGGAGAAGCACGTTCATAACTTCATGATGGACACTCAGCTCACCAAGCGGAT


CAAGAATGCTGCAGCCAATGTCCTTCGGGAAACATGGTTAATCTATAAACACACAAAGCTGCTAAAGAAGATTGACCATGCCAAAGT


GAGGAAACACCAGAGGAAGTTCCTCCAAGCTATCCACCAGTTGAGGAGCGTCAAGATGGAACAGAGGAAGCTGAGTGACCAAGCCAA


CACTCTGGTGGACCTTTCCAAGATGCAGAATGTCATGTATGACTTAATCACAGAACTCAATGACCGGAGCGAAGACCTGGAGAAGCA


GATTGGCAGCCTGGAGTCGAAGCTGGAGCATCTCACCGCCAGCTTCAACTCCCTGCCGCTGCTCATCGCCGACACCCTGCGCCAGCA


GCAGCAGCAGCTCCTGTCTGCCATCATCGAGGCCCGGGGTGTCAGCGTGGCAGTGGGCACCACCCACACCCCAATCTCCGATACCCC


CATTGGGGTCAGCTCCACCTCCTTCCCGACCCCGTACACAAGTTCAAGCAGTTGCTAAATAAATCTCCCCACTCCAGAAGCATTACC


CATAGGTCTTAAGATGCAAATCAACTCTCTCCTGGTCGCTTTGCCATCAAGAAACATTCAGACCAGGGAACGGAAAGAAGAGAGACC


GAGCTAATTAACTAACTCATGTTCATTCAGCGTGCTTGGTCCGACATGCCTTGAAACCAGAAATCTAATCTCTGTTTAGGTGCCTCT


ACTTGGGAGCGGGAAGAGGAGATGACAGGAAGCGACGCCTCTGGCAGGGCCCTTGCTGCAGAGTTGGTGGAGAACAGAAATCCACGC


TCAATCTCAGGTCTTCACGCGGGGGGTGGGGGTCAGATGCACTGAAGTAGCCAACAGCGAAGCCAGTCCAGAAGAGGGGTCCGCTGG


GAGGGAGGGTTGTGTCAGGCTTGGGGGATGGGCTCTTCGCCATGGGGGTCTTTGAACACACCTCTCTCCTTTCCTTTTGTCTACGGA


AGCCTCTGGGTGACAAAGTAAAGAGAGCTGCCCACAACTTGCCAAACAGATATACTCGAATCAGACTGAAAAAAAAAAAAAAAAAA





HUMAN PROTEIN SEQUENCE:hP27-009.2 (Seq ID No: 30)


               MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQ


QQQQQQQQQQQQPPHPLSQLAQLQSQPVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRH


RQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHN


HQHAGTTASSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTII


LLGLIIAYHTREVQLFVIDNGADDWRIANTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLY


LIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISI


TFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLK


KIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLI


ADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIGVSSTSFPTPYTSSSSC*

















TABLE 4










MOUSE GENOMIC SEQUENCE: mD27-014 (Seq ID No: 31)



AGCTCGGCCAGGGGAAAGTGAAAGTTTGCCTCGGTGCTCTCGGTGTCGCTGCGGCTCTCTGCATCCCAGGACAGCGGCGTGGCCCTC


GACCGGGGCGCGGGCTCTTCAGCCACTAGCGAGCAAGGGAGCGAGCGAACCAGGGCGGCCAACACGCCGTGCCGGGACCCAGCTGCC


CGTATGACCGCGCGGGGCGCCGCGGGGCGCTGCCCTTCTTCGGTAAGCTGCAACCGTGCCGCGCGGGGCCCGGGCCGGGCTGGGGCA


GGAGCTCTGCAGCAAGCAGCAGGCGGCTCTGCGGGGCCACTTGGAGCGGACAGCCCCTTCTCGCCAGCTGCCCAGGCTTCTCGGCCC


TGGGTTCTGGCTTCCTTACTGCTTCTAAGCTACGGCTGAGGCCCGCGGTATTTCAATAGCTGCTCCTGGGGCTGCAGCGCTTTGCGA


GGTAAAGAGAAGGCTGCTCATCCCATTGCACGGAGGAGAACACTGAGCTACCCACAGGCTGGAGAGAGAGATGGGGGTCTGGGGGGG


GGGGGTATCGCAGGGATTGGCACAGGCCCAATGTCTGCCAGAATGGTCAACCAGGTCTCCAGGTTCCGAGTGACACAAGATCCGAGT


GTGGCATCATCCCCAGTAGATATCTTTCTTTGGTTGTTGCACATGTTTTAGGCCCCAGTTGGGAGTGGGCCTTCAGGGTAGGGAAAA


TTCAGGCTCACTCAGCTTTACACCAGGACCTGTGCTGAGCAACCTGTTGGCAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAG


ATGGGCATGCTGCTACTTGTTCAATGGATGTGTAGGAACTATTAGGGACTTGGGTGGCTCTTTGAGGGGAGCTGGACCCGAATCTTT


TCTTGAAGAAAATGAGATGGGGCTATTCTAGACTCTGCGGCTGACTGAGGAAAGAAAGTGCAAGGAGAGTTCAGAGCTGCAGCTGAT


AATGGGCTGCTCAGAAGCTGTCTCCAGTAATGGCAGCAGATGATAGCATGGCTCTTACAGAGTGAAGGATGGTACTTTCAATCCACA


GCAAGTGGGTTTGCTTCAGAAGAGAATGAGAGGGAAAACCTGGAGGGTAGGAACCGAACTTGTGATGGGCAGCGCGTTGCAGGTGTC


TGGGAGGAGAGAAAAGTAGAACAGCAGAGAGAGGGGCTCAGTGAGAGGCAGAAGGTGGGGTTAGGAGGAGGGGAAGGGAGGAAGTTA


TCCCACATGCAACAAGCATAAAGAGAGAAGAGGGAAGAAAAGAAAGACTACAAGGAGACATAAGAGGAAAGAGAGGAGGCCGAGGTT


CAGCCAGGCAGTCAGGCCGGGTCTCTGTCTGCAGACTGTACTGATTGGAAAATGGAACATGATGTCTTGAAGTGCTCAGAGACTGCC


GCAGTTTCCAGGCTGCTCTCATAGTCAGAGGCTGAGGCAGTGGGTGGGAGGAAGAAGCAAGCCAGGAAGAGCCTGTCCAGCCAGATG


CAGGCTAGAGTATTAACCCTTGGGTGTCCATCTGTATCCCTGTCTATGGCAGCATTGGGGTTACAGAGCCAGATCCAGGAGTGGCTG


GTCATCTTTGAAGCCAGCAGCTGTGCATTATTTCTGTGCATGCTTGAAATGCCACCAAAAGCCAGGTAGCCCTGAAGTAATGTCTTT


ATCTTGCTATCTCCAAACATCAATGGCTTGAAATTCCTGGGTTGAGATATTTCTGAACATCTCCATTCCCGGGTCCTTTCCTTCATA


CCATACACACATGGACTGACAGGCTGAGTGATACCAGCCTGGGCCAGAGTCATCTTCTGCAGTCATTTCCTTTAACAGGTTCTGAGA


CTGGGGTTCAGGAGACCCGGGCTGCCACTCCCACTCAGGACTAACTTTCCAATTGCCCAACCATGCCCAATGCAGTTTATCAACCCA


TAGCTGGCTGCACCCTCTCCCCCACCTCTTTCTCCCTGTCTCTCTGTGTCTGTCACTCTGTGTCTCTGACTGTCTGTCTCTGACTGT


CTGTCTCTGACTCTCTGTCTCTCTCTCTCTCTAAGGTCAGGCAAGGAACCTAACAGGTCCTGTGCGTAATGGCATTAGGCAACCCTG


TGCCTTAACACCCATCAGCATCTTCCACCCTTTAAGGCCTCACTCTTCCCTCCGCATGGCCCAGCCAAAGCTGCCTTTCCTCCCTGG


TACTCACTGGCAAGGCTTTGGGCTTTTAGATGTAACCCAGTGTTGTTATGGACTGTTTCATAGCCTCCCTGTGTTTTTCCAATGCGC


TCCTATTTGCAACATTTGTCTCATCATCTGGACTATTGGGGCAGAGCCAGATCCAAGAAGGTGCCAGTCATCACTCCACCCTGCCAG


CATTTCCCTGAATTGGGGGATATCAGCAGCCAGAATGCTCAGAATGGCAGCATCAGGCCAGGGAAAGAAAGCCCAAGAGTCCCTCTG


ACCCCAGGCTGGCATCTCCCGGGATACCCTATTGGAGCCCGAGGGATGGAAGGATTTTAGAGTAGAGGAGGAGGAAGGAAGAAAGGA


GAAAGGAAGGACCCAGTCAGGTGTCAGGAGCCAGACCTAGGACTCTAGGGATGAGCAGCTGCAGGGCCAGGTGGGTGCTGACGGAAA


GGAGAGAACTTTCTTGCTGTGGCAAGAGTTTGCTGACTAGATGAAGGGCCTGATGGGTCTCAGATAAACAGATGCCAGCAGGGAAAC


ACAGCATTGTCCTTGATTAGTCAGCTGGACTCCTCTTGAAATGCAAGTCCAAGGCTCTAGGAGGTCTCCCACTGGAGCTGAGTTCCC


AGTGTTGCATCCTGGTATTTTCCCCTGTAGAACCAGACCTGTGTAACCAGGTGGGAAGGAAGGAATGAAGGAAGGAAGGAAGGTGCC


AGGGGTAATGAGTGTTTCTGGCTTGCAATCTGAAAGCTAGTGACTGACCACAAGTTTGAAGGCAGCTTACAAGGTATCTATTTGTCT


CAGTGTTAAAAGTTAAAAGGATAGAAAATCTTACCCTTGAGTCTCTCAGTCACTAAAACTTATACTGGTTGGCACACCACCAGTATT


ATCATTAGACATTCTCTGTAAGATGGAAAGGTGGCTCATCATTTAAAAACACTTGTTGCTCTTGCAGTGGATCCAGGTTCAAATCCC


AGAATCTAGATGATGGTTCACAACCATTCATACCTCCAGGTCCAGGAGATTCCAAGAAGGAAGCACATAGAGTGTGTGCATGCAAGC


AGGCAAAATATTCATAAACACAAAACAAAAACAGTAAGCCTTTTAAAATTGTCTTTTAAAGTACTCTGTATTGTTGAGCTGCTCTGG


GTTAACCTCAGAAGAGTTCTTGGAGAAGATGGCATTTGGGCTATTACCAAGGGAAGAGTGAGGTGGTGCCCTGGCTGATAAGAATCT


AATGGTGCTGCAGCATGGGAATGGGGCGTTGTTTCTTTGCCCTTAGTGGGACATGGGGGTAGCTAGGGAGAGGAAGTGCTGGAAAGA


CATGACTCCCTTCTGTTATAGACATGGCTGGGCTCCCGGCTGCTGCTGGTCTGTCTCCTCATGAGCAGGAGTATTGCCAAGGAGGTG


TCAGAACACTGTAGCCACATGATTGGGAATGGACACCTGAAGGTCCTGCAGCAGTTGGTGAGTATGAGACCATGCCTTCTCCTCACT


GAGGAAACTGAGGTAGCAAGCCAGAAGGCAGAGTCAAAGAGAGGCTTCCAGAAAACAGTCAAGTGGATAATGGCTCTCCTGGTACTT


CTCTCATTGATCTTTTTAGGTCCTCCCAACCCCTTAGTCTGGGTCACCTGTAGTGACTAGGGTGCGCTTCTAACTGCTGCCTGGGTT


AATGGTTGTCCAGGAATGTCCACTATGGATTCTAAACTGCTCCTTGACCCTGCTCTGACTCAGACAATGCCTCCTTTGGGAAGTCAG


CCCAGTCTGCCTGCTGGGTCCAGATGGTTCATCCTGCTCCTGGATAGCCAGATCCCTGAGCGCCTGGCACCAGGGCCCCACCCAAAT


TTAGATGGGAGGCTCTAGCCTAACTCTGCGCCTTCTGCCTTCATTCCCCTGATCCTTGCCCCTGAGGTTGGAATGCCCTGCTCATCT


GGGCCAGGAAGGAACCCAGGTCCCATTCTAATAGGCTTAATGCAATCTTCAACAATTCTAAATGTCATCTAGCCAGGCAGGATCCAG


TTGTTGTCATGGTTCCTGCTCCTCTCACTAAAGAATTTATTCCACAAGCCCGGCAGGGTGGGGCACCAGTGGGTAAGGCCATGTGCA


GAGCCTGAACTTGGGCCCCCGAGCTGACCTTCCCAATCTCCCTTCTTAACAGCACCCTATGCATGCAGCTTCCATGGCAGGCCCAAG


GCCATGAGTGCTGTCGTGGTCTCTGCTCCAGGGAGAGGCAAGGGCTAGAGACCCAGACTCCCCAGAGCTCAGCCAGCCTCTCCCTGA


GCCTTTTCATGATAGAGTGCTTACCACCTTCCAGAAAAGATTACATCCTATATTTTCCTAGAGATAATTCTTCCATATACAGACTAG


ATTGTGCAATTTCATAGGTCAAAGTAGAAGTGTCTGTTGTTGGCTTTTAAGTACTCTGGGTATTTGGAAGATACAGCTTTTCCCCAG


CTGTGGCTCTGTCATTTTGGCATTGTTTTAGGGAGGTAAAATTAAAACATCATTCACCCCAAAACCTGGGTTCCCCATCCTGAAGCT


GAGTGGACCTGTAGGTACTATGTAACCACTGGCCTGTTCTATCTCACAGATCGACAGTCAAATGGAGACTTCATGCCAGATTGCCTT


TGAATTTGTAGACCAGGAACAGCTGGTGAGTAGCAAGTGTCTGTAAGGTGCTTAAGTGAATATTCACGGCCCGCTCTGTGTTGGCAT


GGAACAGTATGAAGGCAGCAGAAAACCTAGAGCAGACAGGATGAGGGTCCCTGGGTGCTCAAGTGTCAAGTTCCAGCTTGCAGGGCT


GGGTAGGGTCCAGAGCTTAAGTCCTTCTGTTTCCTTACTTTGACCTGGTATAAATCAGGTACTTGCTAAATGCTAGGCACATTCCCC


AATTAATCCTAACAATACAATTCTGAGGTCCACAAATATTGCTTGTTACCCATGCAGAGATTAAGGAGCATGCTTAGCCAAGTGATA


GAGGCCTAATTTGAGCCCAGGAATGTTATACCTTGTAAAGTAAAAAATGTGCTTTATTTTTTAGATCACATCTTCTCCAATCCACTG


GCCAGAGACAGGAAGGCAGTCTAGCCTGGCTTTCTACCCCACACCTAACTGACCAGCCACCCAATGCAGCCAATACTCCCTCTCTGC


ACCTTAGGGTGCTGTCCCTCTCTCCTCCCCAGTCCCTTGGAAATTTTCAGGGGCTTCTTGACTTCCCTGATTCTAGGGCACTCTCCA


TCTTACCACTAGGGGGAGCCCTCTGAAACCCCAAAGCCTTCACTTATTTCGCCTTACTTGTCAGGAGCCCCATGGCTCCAGGAGAAA


GCACAGTCTAGTTCCAAGTCTGCAGTACCTACCACACCCTACGTTCATTTCCCTCCTCTGCTTCATTCTGCTCCCCAGCTTTTGCAT


CAGCTCTTTGTGATGTCTTTCCATCCTTTCCATGTGCCCCGCTGATCCCTGTGCTACACACCTCCCTATCTTCAAGCCTCAAGAGAA


CAGTCAGGCTACCCAGAATTCCTTCTATCTCTGAGCTCTCATGCACTAGACCCATGCATCTCTGTGAACATGCCATGGCCTGCATAG


TCTCAGGGTTTCTTCCATCCATTCTATTGCTCCTTCACTTGCACCATGGCACCTATTTATTGGATCAGGCACTAGAGATACAGAGAT


AAAAGTAGTTTCTGTCTTTGAACCAACTACTGTATCCTTGGAGACAAAACCCAAGGCTACACTTTTGACAATGAGGTAGTCCTCCCT


CAGTATTTTTATATTTTGGAGGTTTTGAGGGGGCCATATGGCAAAAATAAAAAGTGGAAGTAAGCTGAAAAGGAGAGAGGAGAGAGA


GAGAGAGAGAGAAAATGCTAAGGGGCAGCAAGGCTGAAACCCACCCTCCCCTGTGTCTCCTGAATAAAGCTGCATTGCAGAAAAGCT


CTCTCCAACCAGAATCCACCTTTCCTTCACGCCAGCCCAACTCTCCATCATGGTTGATTTAAAGAAAGAAAACAAAACACAGGCCAA


GGGTATCACCATCCTCATCACCAGGGTGGTGTGTCCCTTCCTCAGATTACAGGGTGACAGGCTACAGCCCTCTGTCTGCCTAGGGTG


TGATCGTCTCATATAAAGCCTGGGTTTCCAGGCCACCATGGCCAGGTGCTAACCTCCTGGTTCCTGTATTCCAGGATGATCCTGTTT


GCTACCTAAAGAAGGCCTTTTTTCTGGTACAAGACATAATAGATGAGACCATGCGCTTTAAAGACAACACCCCCAATGCTAACGCCA


CCGAGAGGCTCCAGGAACTCTCCAATAACCTGAACAGCTGCTTCACCAAGGACTATGAGGAGCAGAACAAGGTAGGGTGGATTCTGG


GGCTGGAGCACCAGAGAAGGGCAGAGGGAGGCTACAGAGGTCCCACCCTGCCTCATATGCTCACCGAGCCTGAACCTTACTAACTTA


CTCCCTTGCCCATTCATTTCTTATGCCATCCGCCTTTATCAAGCATTCATTAGACAGAAGGCACAGTGCTGGACCCTGAGGATATCC


TTGGAACAAGAAATTCCCCTTCCCACCCTTACAGGGCTTATAGCCAAGTGAGGTAGACAGCTGTTAAATGATGACACCTATAAATAT


GATCAGAAGGGCTCTTCATTCATTCAGTAAAACCTTACTGAGTGACCATCAAGGGATGTTCTGAACACCAGAAATGAGCTGTGATTT


TAAAAAGGGGGGGGGCAAAAATCCCCACAATCATGACGAGAGGAGGGGTGCTGAGGCAGCTAAAATGAGCAAGTATGTGAATGGACA


ATGATGCTAACAGCATTGGAGAAGTGTAGAGCAGCAGGTGAGGGGCGCCCTGGGTGACAGTGAGAGGAACAGGAACCCGAGACTCTG


AGTGTGCGGTGAGGAGCTAATGTAATGAGGATGCAGAGGGGAAGAGGCAAAGGCAGCTTCTAAGCAAGAAAACTTTAGCCGGCCCTC


CAGCGTGAGGAAGAGCAGTAAGAGCCACAGACAGAGAAACAGAGTGGGGAGTGCTATGCTCAAGCCCTAGGGTAACCAGAAAGGTTT


GCATTCAGAAATCCAAAGCGGCTCACCATGGCCCAGGCATGGGGTGTGGACAGGAGGAAGCAAAGTCAGGAAGCACTGCATTCATGC


ATGGTGTCAAAGAGGTGGGCTTTTTGTCTAAATTTGAAAGAAGCCACCATAAGCTAGTGAATGACACGATGTCATATATGATGGAAG


ACCATCTGGTGGTGAGGACGCTGTGGAGAGCAGGAATGAAGGGCAGGAGGCCAGCAGGAGGTTCAGCCAAGCTGGGCATGGTGGTGA


GTTGAATCCGAGGGGAGCAGGGGAAATGGAGGTGAGTGGGTGTGATCCCTCCAGACAGACAGGACTCCATGCTTCCTGGCAGAAGGG


GAAGGGTGAGTGAGGATGCTCTCATTTTGAGTCCCTGGAGTTCTCACTGATGTCAAAATAAGGATGACCTCAGGCAGAGTAGGTTTG


AGAGAAGAGCTCATTTTGGTGTGAGGCACATCTGACAGCTGCAGGCGCGGCTCATGACTGTGAATGCTGGACATACAGATGCTGTTT


GCAGAGCCACAGAACTGCACAGCCCTGCCCATCCTTCTCACCCTGGTGAGAAGAGAAGGGGATCCAGGATCCTGAATCCTGAATGCA


ATGCAGCCTGAGGTAGGAGGAAAACCTAGAGAGGGCAGGGCTTCCAAATGGAAGGAGCCAGAAGCTTTATCAAAGGAGGCTGAGAAG


TCAATTAAGGTAGTGTCCATTGGTCTGTCTCACTTGGCAGCATGGAGATTGCTGTTGGAGGCAGGTGGGGAGAAAAGAAAGAGAGGA


AACAGAGACCACAAAGTAGAGGAGCTTCGCTCCAAAGGGGACAGAGAAGCAGATGTTCTGGGGTGGCTTTCTGGTGGAGGAAAGGCT


GGTTCTTTACCATGCAGAGATTCACCCGGAGAGCTTATTTAAAATGCAGAGTCCCAGCATCACTGCTACGGACTCTACTTTCCTGAG


CTCATAGGTGAGCCTGGGAATCTGCATTTTGCGAAGCTGCCCCATCAGTGGTTGAGATAGAAGCCCCTCAGTCTTTCCTGGGCCGGT


GACCATTCACTCAGTCCATGCTGTGGGGTGGCTCAGGGGAAAGACAGTGTAAGCCCAAGGAGCCAAGTCTAGTCACATGGCTCAGAA


AAGGAGTATGAGCTCCGGAACCAGCAGGCTCCACACTGAGAAAGCTTGGGTGTCAGGTTCTAGGGGAGGATGCCTGGTTTCTTCTAC


AGCATATAAGGCAGGTTTGAGGGAAACAGCTTTATAAAGACACATGCAGGACAGAGCCAGCTGGCCTGACTTAACAGCTCCTGGGAA


AGGCTGGCTGCTGTTGCTCTAACATCACAAACAAGGAGATGAATCCACAGAAAGCCGGTCTATTCTCACCTAGCTGCTGAGTGATGA


ATCCAAGCCCAGGTCATTTCATTCATTATTTGCCTAGTAAGTGTTTATGAGCCTGCTATGGGCGGGCCAGAGAGATGCAGTGATGTA


ATCAAGGGAGCTATAGTAGCCGTAGAAAACCTATTGTTCTTCCCAGAACAGCTCAACTTCAAGGGGGAAAGTTGGCATTCTGGAAAT


AAGCCGTAACACATATAGCTTGCTGTGAAAGGTGAGGTGGACCTAGGGCAGAACCCTGCAGCACTGCAGTATTTAGAAGGAACTCTC


TGGCACAGAGCCTGAAGGAGCAGCTGGTGAGGAAGGAAGAACTCTGGAGAGCCTGGCTTCTCCGAGCTGCATGGGGTGTGAGTGTGA


GCACCTGGGCCCAAGGCAGAGGAGAAAAACCACTCAACAGGCAGGCCAGGGAGTCCTCAGCTCTTCCTCCAAAATGTGGCACCAGCC


AAAGACCTCATCTCCTCTGATCTCCCCAGGTCTGCTCTCTACACCGTACCAAGATGATTTTCCTAAAATACAGGTTTTATACCATGG


TTTTAAACCTCCCCAGCAGGTTTTCAGTTTCCGGTTGGCTCTGTGAATTACAAGTTCCTGGCAGAGTCAACAAGTCCTTGGCCTTGG


CAAAGCCCTTTCAGCTGCCACTTTCTTCCCACGTGGCAAAGCTGCACCCGCTCCAGCCTTCTTTCACTCTTTTGCTGACTCATGCTT


TCCTGCCCCAGGGCCCTTGCATCCTCTATCATCTCTGGCCCCACTTCCTTCTCTTCCCTCGCTCATCTTTTAGCTGTTCCTTTGGAG


ATCTTCTCCCTGGGCCCTCATCTATCGCCCATTTGTTACACACCTTCTGATGGTTCAGGACACTCTCTTGAGAGTCACTGTGACTTG


TAACAATGTGTCTGCTGGACTCAGTGCCCAGCTTGGCCAGGAACCACTTCTCTTTTGTTCATTGCATGATGCCCAGGTAAGTTACCA


TATATCTGGCACTTAAACGTGTGTTAGATGGATCTCTGACTAAATGACGCATCTCTCAACCTCAAGACTGATGCTGCTGCAAAGCAG


AGAAGGAAGGAAACAAAAGGGGGAAAGGAAATGCCTGTGAGAAACCCCAAGAGAGTTTGACAAAAATACCAGTGAGAGGTAGCCCAA


TGTTCATGCTTACCAAAGGGGGCTCCACTCTCCTCCAGGCCTGTGTCCGAACTTTCCATGAGACTCCTCTCCAGCTGCTCGAGAAGA


TCAAGAACTTCTTTAATGAAACAAAGAATCTCCTTGAAAAGGACTGGAACATTTTTACCAAGAACTGCAACAACAGCTTTGCTAAGT


GCTCTAGCCGAGGTAAGCACAGAAGGGGTCAGCTACAGGGAGGGTGTGTGCAAGGTGAGACGGGGCTAGGGGAATCCCAGAGGCAGC


CTGGGTGCTAAGTGTGTTTCTGTGTTTTGTGTACTCGTGTGGCTTCATGTACCTTAAGGTCCTGGGCACATGTCTCTGCTGACATGT


GTGTGCATGTACACTGACTTATGCCTGCATGTACTGTCTCACTGCCAAACTTCATGTGGCAGCATCAAGAAGGCCCCTGCTGGTAAC


TGTGATGGAAGTGAATGGGTAAGGGGACCTTTCTTAGAAAGCCATATAGGCATGGTGGCGTCCCCCGGGCTCTGCAGGCTGGCTGAA


TAAATGGGGGTTCCGGAAAGAGCAGGTGCTCCACCTGGCAATCAGGGTCCTTGCTCCAGGAGCTCTGCTGCAAAACACCAGGATAAC


CTGGCTCCAGAAGTCCCCAGGATGCCTTGGATGTTCCCTCAAGGGATAAGGCTGGATTTGAAGTCTGAACATCATTCAAACTCTCTC


TACCTGTGCACTCTGAGTGTACTCGTCTCTGCATCCTGTGCCACGTGTGTCCTGCGTTCAGCCTCGCTCCCCAAGGCAGGGGCTGAG


GTCCTGCAACCAGACAATAGCCACATCCAGCCTTAGTGCTTCAATTCCAAAACCCTGAACTTTGGCTGCTTTCCAGCCCTGCCTTGC


CCTGCCTGTGGCAGTGGCTGAGGTGGTTCCACTCCTGGCTGTGCATGAAACCAGTGTCTTGGAGGCTTCTGAGTGTCTTGTGTTAAT


CCAGGAGCTATTGCTCAGCCCTGTGGCCTGGGTGCTGCTAACCCCTGGCTTGGCTTCTGGCCAGCTAGAGCCCCAGTACACTGTCCT


GTGGTCTTCCTCACCTCAGTCCTTCTCTGTCTGTCTGTACCTTGCTTTTGGTTCCTAGTCCATATCCCCTGCGTATTGATCCCTCCT


GCCTGAGTTCTGTGTCATGATCGTTTATTACTGTCCTGCCCTCTCCACCGCCCCAGGGCTGTGTTAGAAGAGGGACCCCCTTCCCAT


GCCCCAGGGCCATATGCCCCTCTTAGCCCCTCTGGGGGAGCTGTGCTGGAGGCTGGTGACTCTATCTCCTCCCCATCTTTCTCTCTC


CCCCTCTCTGTGGTTCTTTCAGATGTGGTGACCAAGCCTGATTGCAACTGCCTGTACCCTAAAGCCACCCCTAGCAGTGACCCGGCC


TCTGCCTCCCCTCACCAGCCCCCCGCCCCCTCCATGGCCCCTCTGGCTGGCTTGGCTTGGGATGATTCTCAGAGGACAGAGGGCAGC


TCCCTCTTGCCCAGTGAGCTTCCCCTTCGCATAGAGGACCCAGGCAGTGCCAAGCAGCGACCACCCAGGAGTACCTGCCAGACCCTC


GAGTCAACAGAGCAACCAAACCATGGGGACAGACTCACTGAGGACTCACAACCTCATCCTTCTGCGGGGGGGCCCGTCCCTGGGGTG


GAAGACATTCTTGAATCTTCACTGGGCACTAACTGGGTCCTAGAAGAAGCTTCTGGAGAGGCTAGTGAGGGATTTTTGACCCAGGAA


GCAAAGTTTTCCCCCTCCACGCCTGTAGGGGGCAGCATCCAGGCAGAGACTGACAGACCCAGGGCCCTCTCAGCATCTCCATTCCCT


AAATCAACAGAGGACCAAAAGCCAGTGGATATAACAGACAGGCCGTTGACAGAGGTGAACCCTATGAGACCCATTGGCCAGACACAG


AATAATACTCCTGAGAAGACTGATGGTACATCCACGCTGCGTGAAGACCACCAGGAGCCAGGCTCTCCCCATATTGCGACACCGAAT


CCCCAACGAGTCAGCAACTCAGCCACCCCCGTTGCTCAGTTACTGCTTCCCAAAAGCCACTCTTGGGGCATTGTGCTGCCCCTTGGG


GAGCTTGAGGGCAAGAGAAGTACCAGGGATCGAAGGAGCCCCGCAGAGCTGGAAGGAGGATCAGCAAGTGAGGGGGCAGCCAGGCCT


GTGGCCCGTTTTAATTCCATTCCTTTGACTGACACAGGCCATGTGGAGCAGCATGAGGGATCCTCTGACCCCCAGATCCCTGAGTCT


GTCTTCCACCTGCTGGTGCCGGGCATCATCCTAGTCTTGCTGACTGTTGGGGGCCTCCTGTTCTACAAGTGGAAGTGGAGGGTAAGG


AGGACCCCAAGAGAGGAAGACATCCTATGGGGCAGAACAAAGGCTGGGTAGGGTACAGGCTGGAGGCTAACCAGGTTCCAATACGTT


ATGCAGTTGCTGGAAGGTGGGGATGACAGCCCGAACGGTAGACGGTAGTGATGGAGTGTGGCTTCACACAGGAGCTGCCAGGTTTGG


TGGTGTGCATTTAACCCTAGCAATCCAGAGGTACAGGCAGGCCTCTGATCTACTGGTCAACAAAGCAAGTTCTAGGCTAGCCGAAGC


TACATAGATCCTGTCTGAGAAAGTAATTAATCAATTAATTAATGAGGTCTCCAGCCTCAAGATCATTAAGAAAGGATGAGTTCTAGG


CTAGTCAGAGCTTCATAGAGAGATTCTGTCAAATAAATAAATATATAAATAAATAAATTTAAGAAGTTTCCAGACTCCTTGAGATTA


TTGAGAAAGGATGAGAACAGAATCCTGTAGAAAGGAGAATTCTTGGCTGGGAACTCAGGAGGCAGAGAGGCAGAGAGAGAGGCAGAG


AGAGAGGCAGAGAGGCAGAGAGGCAGAGAGGCAGAGAAGCAGAAAGGCAGAGAGGCAGAGGCAGGTGGATCTCTGTGAGTTTGAGGT


CAGCATGATCTACAGAGTACCAGGGCAGCCAGGGTTGTTATGCAAAGAAACCCTGTCTTGAAAAAAATGAGAGAGAGGGAGAGGGAG


AAGGGATGGGAGACGGAGAGGGAGAGAGGGAGAGAGAGGGGGGATATTCTTAAACAACCAAGTGGGAGAGGGAAGGAAAGGGGAAGA


GCTTGAGGGAGCTCTGGGAGCTTGAGGGCCTATAGGTGGTATTCTACATGGGAGGGGACAGGAGAAGGCGCACCCATCCTCAGAGGC


CCAGGAATCTCCCCCAGCTGTGCATGCTTTGGGGTAGTGGGAGGAATTCTAGCAAGTCTCTCAGTGATGCTCAGGGGCATGCCAGCG


CCTCAGTGAGATAAATCTTTCTTGTTCTCAGAGCCATCGAGACCCTCAGACATTGGATTCTTCTGTGGGGCGACCAGAGGACAGGTG


AGCAGTTGGAGTGGGGCTATAGGAATCACTGGATGTCTGTCTTGGGACCTGCTTCCCCTCAAGACTGAAAGAGAGGCTTCTCCCCCC


TTGCCCTAGGAGATAAGCTGCAGAGCAGGGTGGGTACCAAGAAAGAAGGGCCCCTCTTCTTCCCATGAAACAGTGGAGCTTTCTCCT


GATTTCTTCCTGGAGTTGGGCAGTTCTGGGTCTTCTAAATCTCACATAGATGGAATCCACGTGCAGGGTTGGGGGTAAGCTAGGAGG


TCCCCTCAGTCCCATGCTCCTGCTGAAGTCTTATGTCAGCCCTGTGTTCTGCCTGCAGCTCCCTGACCCAGGATGAGGACAGACAGG


TGGAACTGCCAGTATAGAAAGGATTCTATGGTAAGGTTCTGATTTTGATATCTCTCTATCCCTTAAAAAGAACTATCTCCAGGTACC


CAGTCCTGTTGTAGAAACCACCTGATGCCCAAGAGGCCCACACATTTCAACTTCCTCTCCCCGTCCCACTCCCAAGCCCATACATTC


ATCATCACGTCTAGCTAGGCTCCTCTCTTCCAGGCCTCAGGTCTCCTCTTGCTCCTGAATCCCTGCCCTGGACCAGTTACTGCAACC


TCTGCATTATGTTTCTATTCTTGCTGTTGCTACATCTGATCCCAAAGCAACCACATTCTTCCTCCTCTAATGAGGCTTTTTACAAGG


TCTTTACCACCCTGGAGAATTTTCATTAGCCTTTGCATGGCCGCCAGCCCCCTTCAAATACGTGCATTTCCAGCTTGGTGCTGAGCC


CTGACCTCCTCAGCATCCTCTTCTTGCCAAATTGTGCCTTATCTGGTCCTACTCCCAAGCCAAGGTTATTGCTGCCTCCCTGATTTA


GGATCATTGTGCCATAGAAATTTAGTCTTAGGAGAGCTGTCGAGAGGTCATTTGGCCCAGTGTCCCAGCCTAAAAGGGTTACTCTGC


ATCCCCCACAGGGAGTCAGCCAGCTTCCTGCACACACACACACACACTCCCAGTTCCAGGCAAGTTCTCTGCATGCCAGTCTGCTCA


ACTGGGGTCACAACATTGGGGTCACAACACACAACACTGGGGGAGTTCCTTCCTTATGTAGGCAAAGCTGCCTTCCTTTCTTCCCTT


CCCAGACCAATCCTCTCTCATCTTCTCATGAGGCCTGATATTTAAAGTCAGCTATTCATGTCACCTTTTAAAATTCTCTGTGTTAAG


TGTGGCCAAGCCCCTCAAACATTCCTTATATGATATGGTTTTCAGACCCCTCACCATCCTGGACACACTCGTTTGTCAATGTCCCTC


TGAAAATGTGGCGCCCAGCCCTGGACACAGTACTCCAGATGTTGTCTGACCAGCTCAGAGTACAGTGGGACGGTTGTCTTCCTTGAT


CTGGACAGTACTCTTCTACTCGTGCAGATTAAGATCACATTAGTTTTAACACCTGCATCATATATTGTCATATGTTGAGCTTGTAGT


CTATTAAAAACCCCAGTTCTATTTCCTGTGAACCTTTGTCCAGTAGACCGTCGCCATCCCATACTCCCATACTTGGACACAACCGTT


TTAGCCAAAGTGTAGCTGGTGCTCACCTTTGTTAAAACTCCTTGTTGTTTTCTGCCCATCCCCTGAGCCTACTGAAAGTGTTTTAGT


TCCTAATTTGGTCACTTTATAACTCCTGGTTGGGTCCCCTGCACATTAATGCGTGTCTTTTGTTGTCCTTGCCCACGCTATTGGTGG


AGATCTGACCTGTATTCTTCCTCTACACCCACCCACACCAGCCTATCCAGAAGCCTTCCCTTCCTAAAATATTCCACATCCCTCTGG


TTGATCTTTTAATTCATTCTGCTCTGTTGTATATGGCTGATGCTATATTAATCCACATACATTTGGATGTTGTTTTATGTATTTTAA


ATCATATTTTATGTATATATGTAAATTTTGAACTACTAAGAAGATTGTAAGCCCCTAGAGGGCAGGGACTATCTTCCTTTTTATTTT


TTTTCCCCTTCACTTCATTAATTCTAGTACAGACAGTGCCCCCTCTATCCTTGTCAAAAACTTAGTAAATGGTGGTAGCTGTTTTCA


GGTCTGAATCACCAACTAACCCCGGCCAGATTTCTCTAACTGACCAGCCTTCTGGCTGACCAATTAACTAGCCAACTAATCAACTCA


TCTTACCAGCTAGTTGGCTAACTGACTACTTGGCCAACTAGCTGGTAACTACTTAACTGACTAGTTCTTGATTGATGAGCTGATTGG


CTAACTAGCTGGCAGAGTGCTTAGTTGATTTGCTGACTGACTGGATGGCAAACTAGCTGTGTGATCGGTTGAAGTTTCCAGTTATAC


CCCTTGCCACATGTAAGCAAACTGTCCCATGTGTAGGATGATGTGTCTAAGCCCCTTTCCCAAAGGAAATATCACAGATGCTCAGAG


AGCCAGGGAGATTTATTTGAATTAAAGCAAGCAGCAACCCATATCTAGAATCCCGGGGACCCACTCAGCAGTAATGTGGGTCGAGAC


GGGTGAAATGAATTAGCTGGCTCACTGGAACAGCTACAAGGACACAGAGTCCCTCTGACCTGAATCAGAGAGCAAAGGTTGCTGGGG


ATTTGGGGGCTCAGTGCTGTGTCACCTTACCAAGGGCTACCAGGGTTCTTCCTCCCTGCCACCTGTATGACCTTGTCCTCGGCCCTG


GTTTCTCTGTACCCAGTTGTCCTTCCCATGCCTCCTAACTCTCAGACCTGCCCAAGATTTTACGTTCCTCACCTAAGGATTTCAAGA


TTTCACTCAGTCAGCGCAGATCTAACCTGATCCCCATTCCAGGCTCAAGGAGCCTATGGGAACTGAATGTCTGTGTCCTGATTGACC


AATACTCTGACAAGGAGATGAGTGGGGCACACAGAAGTGGGGACTAAGAAAAGGTCACCAAGTTGTAGAAAACTCAGGCCCTCGGCC


CCAGGAAACTGGGAGTTGGGTTAGAGGCTAAGGTCATGCCCTCTGGGGCCTTCTTCCCGATGGGCCCTGCCAGAGCCTGTGGCCTGG


TTGTACCAGTATGGCTCATGCCCAGTTTATAGTTTCTTCTTGTTTCCTATCCAAAGCATGGGAATAGGCTGGTGGCCAAAGGCTGTA


GGTCTCATTTTCTTTCATACCCATCACAGGCTTGACCAGTGGGGCTATGGACATTACTGGGGAGGCGCCATACAGGGTCCAAAGTCA


AACTGTTGGCTGAAGTCCAGGGGATTTCTGCTATGGAACAAAGAGTTCTGAGGATACTGGACAAGGGGACAAAGATGGGGGTGGGGT


GGGGAGAGGGCAGGGCCCTGGCTCCCATGGATGACAAGAGGCAAGTCCCTCATCCCATCTGGGAGGAGGCTAGGCTGCTTGGGGTGA


GCATGCCTGTTGACAGGGCAAGCCCTCCCTTTTCCTGGCATTGTCTCTACCCTCTGCCCCTCAAGCCTGAGTTCTTTCTATTCAAAT


GCCTTTGCCCAAGTGTCTTCTGTGCAGATACCCTCTAAGGGATGGTATGAGAGTTGGCAGAGATCACCTTAGGTCATTGGTCTAAGA


CTACTGAGATGGCCTTACCTGAGAACTAGCCTAGTAGGGGCATTCAAGAGCTTGTTCCCTGCTCCCATCTGCTAGAGCAATAGCCCT


CTCTCTCTCTTGGCCTCGACCTCCTCCAGTCTTAGTCCCTCATTTTGTGGTCACTACTCCCCCAGGAGCAGAGGTAGGAGGTGAGGC


CAGGCTATCCAAAGGCTTGGACTGCTGCCAGGCAAAGCTGCCTGGTCTCTCTGTGGTGTCTGGGGTCGCCTAGAGGGCCAGGAAAAT


GACCAGAGGAAGTCTTGCCTTAAGTCAGCCAACAACCCACAGGAATGTCACACCTCCCCCAACTATGTCCTTAGCGACCCTCCCCCA


CACTCCCCTGCTGACCAGCCTTCTTCCCTTCTTTCCCCTACAGCTGGGCACACAGGACTATCTCTTTATGGAAGGAGACATATGGGA


ACATCCACCACTACCCTCTCCTACCATCTTCCTGGGAATGTGGCCTACCACTACCAGAGCTCCTGCCTACCAAGACTGGATGAAAGA


AGCAGCTTTGATGGCGTCTTTCCATCCTCACCCTTAGACTCTCAACCAAAGAGAAAGGGCTGGAGGATGCCCCCCACATACTGCCAC


TATTTATTGTGGGCCCTGGAGGCTCCCTGCATTGGAGGAAGGGCAGCTCAGCAGCTCAGGACCCTTTCCCTTAGGGGCTGCTTCCTC


CCCTCAAAACCAGAACCTGGCAAGGGACTCACTAGCCTGGATGGCCCATGGGAGACCAGGACAGATGAGAAGGAGCAGAAGAGCCCT


GTGCCCAGAAGACCCAACTGGTGCCAAGGAATCCCAGCATGGACAGGCAGGGACCTGTTTCCCAAGAAGAGAGCCTGATATTCAAAG


GGTGGGACAGCATCTGCCCGACTTCCCGTAAAGGCATAAAGGCACGCAGCCCAAAAGACGGGAAGAGGAGGCCTTTGGCTGCTTGTG


TTGACAGCTTAAAGGGGTCTACACCCTCAACTTGCTTAAGTGCCCTCTGCTGATAGCCAGGAAGGAGGGAGACCAGCCCTGCCCCTC


AGGACCTGACCTGGCTCATGATGCCAAGAGGAAGACAGAGCTCTAGCCTCGTCTTCTCCTGCCCACAGCCCCTGCCAGAGTTCTTTT


GCCCAGCAGAGGCACCCCTCATGAAGGAAGCCATTGCACTGTGAATACTGAACCTGCCTGCTGAACAGCCTGTCCCATCCATCCCTA


TGAGTGACCATCCGTCCGAATGTTCTCCCACTTCCTTCAGCCTCTCCTCGGCTTCTTGCACTGAGCTGGCCTCACGTGTTGACTGAG


GGAGCCCCTGAGCCCCAACCTTCCCCTGCCTCAGCCTTTGATTGTCCAGGGTGAAGCTGTGGGAGAACCGCCTGGGCTACCAGTCAG


AGCTGGTCTTTGGGCTGTGTTCCTTGCCCAGGTTTCTGCATCTTGCACTTTGACATTCCCAGGAGGCAAGTGACTAGTGGAAGGGAG


AGAGGAAGGGGAGGCAGAGACAAAGGCCACAGGCAGAGCTATGAATGAGAATGGGTCTTGAAAATATGTGTGCACCCCTAAGCTTGA


AATTGATCTCTATACTCTAGCCCCTCAGCCAGCCTCCTTCCTGTTGTCTGAAACCTGGAGCTAAGCAGGTTGTCCTGTCACAAGCTC


TGGGGACTGAGCTCCATGCTCCAACCCCACCCTCTTCTGACCTTTGTTCTCCAGACCTGACCCAGGTAGGCAAGGGTACCCTCCCAG


TCTCACCTACCATACTGTGCCATCTCTAGCCAAGCAAGCCAGGTTTAGAGAAGGGTCAAAAAAAAAAAAAAGGGTTGTTTACTTCCA


ACTTGTTCTGATGCCCTCTGTTTCCCAGGCCAGGCTTGTCTGTGGTGACCTGGGCATGGGTGACAGGGCTCTCATTTGCCCCTTGGT


CTCTTTATGCTGCTGAGTCCCCCTTTCCTGCCCTCCCTGGCTACTGGGTCAATAATCTTTCAGGCCATGAATCTGGGAGGAGAGTGG


TCTGTAAGCTCCATCAGCCCTGTCCTGAGACAGCAGGGGGGAAGGACACTGGAGACTTTCTTGTGGGGCTTACTTAGCCTTCTGGTT


ACAGACTATTTCCATGCTAGAAAATACATATTTTAAAATAGAAGGAAAAACACAGAAACAAAACAAAACAAGGCATTCTCTACCCCT


CCACCTTAAACATATATTATTAAAGACAGAAGAGAAAATCCAACCCATTGCAAGAAGCTCTTTGTGGGTGCCTGGTTACATCGGAGC


AGGGGAGCCTCAAATCCACCTTTGGAGCCGCCCCTGTGTGCATTAGGAACCCTTCTCTCCTCTGAGAAAGCTCAGAGGGAGCACTGC


CTCACAAACTGTGAGACTGCGTTTTTTATACTTGGAAGTGGTGAATTATTTTATATAAGGTCATTTAAATATCTATTTAAAAAATAG


GAAGCTGCTTTTATATTTAATAATAAAAGAAGTGCACAAGCTGC





MOUSE mRNA SEQUENCE: mR27-014.1 (Seq ID No: 32)


GGGAAAGTGAAAGTTTGCCTCGGTGCTCTCGGTGTCGCTGCGGCTCTCTGCATCCCAGGACAGCGGCGTGGCCCTCGACCGGGGCGC


GGGCTCTTCAGCCACTAGCGAGCAAGGGAGCGAGCGAACCAGGGCGGCCAACACGCCGTGCCGGGACCCAGCTGCCCGTATGACCGC


GCGGGGCGCCGCGGGGCGCTGCCCTTCTTCGACATGGCTGGGCTCCCGGCTGCTGCTGGTCTCCCTCCCTGGCTACTGGGTCAATAA


TCTTTCAGGCCATGAATCTGGGAGGAGAGTGGTCTGTAAGCTCCATCAGCCCTGTCCTGAGACAGCAGGGGGGAAGGACACTGGAGA


CTTTCTTGTGGGGCTTACTTAGCCTTCTGGTTACAGACTATTTCCATGCTAGAAAATACATATTTTAAAATAGAAGGAAAAACACAG


AAACAAAACAAAACAAGGCATTCTCTACCCCTCCACCTTAAACATATATTATTAAAGACAGAAGAGAAAATCCAACCCATTGCAAGA


AGCTCTTTGTGGGTGCCTGGTTACATCGGAGCAGGGGAGCCTCAAATCCACCTTTGGAGCCGCC





MOUSE PROTEIN SEQUENCE: mP27-014.1 (Seq ID No: 33)


MTARGAAGRCPSSTWLGSRLLLVSLPGYNVNNLSGHESGRRVVCKLHQPCPETAGGKDTGDFLVGLT*





MOUSE PANTHER CLASSIFICATIONS


FAMILY (SUBFAMILY)


MACROPHAGE COLONY STIMULATING FACTOR-1 (MACROPRAGE COLONY STIMULATING FACTOR-1)





BIOLOGICAL PROCESS


Immunity and defense (2.16.00.00.00) > Macrophage-mediated immunity(2.16.05.00.00)


Immunity and defense (2.16.00.00.00) > Granulocyte-mediated immunity(2.16.04.00.00)


Developmental processes (2.23.00.00.00) > Mesoderm development (2.23.10.00.00) >


Hematopoesis (2.23.10.06.00)





MOLECULAR FUNCTIONS


Signaling molecule (1.02.00.00.00) Cytokine (1.02.01.00.00) > Other


cytokine (1.02.01.99.00)





MOUSE GENE ONTOLOGY


No Gene Ontology





MOUSE PROTEIN DOMAINS (INTERPRO SIGNATURES)


No Domain Hit





MOUSE mRNA SEQUENCE: mR27-014.2 (Seq ID No: 34)


AGCTCGGCCAGGGGAAAGTGAAAGTTTGCCTCGGTGCTCTCGGTGTCGCTGCGGCTCTCTGCATCCCAGGACAGCGGCGTGGCCCTC


GACCGGGGCGCGGGCTCTTCAGCCACTAGCGAGCAAGGGAGCGAGCGAACCAGGGCGGCCAACACGCCGTGCCGGGACCCAGCTGCC


CGTATGACCGCGCGGGGCGCCGCGGGGCGCTGCCCTTCTTCGACATGGCTGGGCTCCCGCCTGCTGCTGGTCTGTCTCCTCATGAGC


AGGAGTATTGCCAAGGAGGTGTCAGAACACTGTAGCCACATGATTGGGAATGGACACCTGAAGGTCCTGCAGCAGTTGATCGACAGT


CAAATGGAGACTTCATGCCAGATTGCCTTTGAATTTGTAGACCAGGAACAGCTGGATGATCCTGTTTGCTACCTAAAGAAGGCCTTT


TTTCTGGTACAAGACATAATAGATGAGACCATGCGCTTTAAAGACAACACCCCCAATGCTAACGCCACCGAGAGGCTCCAGGAACTC


TCCAATAACCTGAACAGCTGCTTCACCAAGGACTATGAGGAGCAGAACAAGGCCTGTGTCCGAACTTTCCATGAGACTCCTCTCCAG


CTGCTGGAGAAGATCAAGAACTTCTTTAATGAAACAAAGAATCTCCTTGAAAAGGACTGGAACATTTTTACCAAGAACTGCAACAAC


AGCTTTGCTAAGTGCTCTAGCCGAGATGTGGTGACCAAGCCTGATTGCAACTGCCTGTACCCTAAAGCCACCCCTAGCAGTGACCCG


GCCTCTGCCTCCCCTCACCAGCCCCCCCCCCCCTCCATGGCCCCTCTGGCTGGCTTGGCTTGGGATGATTCTCAGAGGACAGAGGGC


AGCTCCCTCTTGCCCAGTGAGCTTCCCCTTCGCATAGAGGACCCAGGCAGTGCCAAGCAGCGACCACCCAGGAGTACCTGCCAGACC


CTCGAGTCAACAGAGCAACCAAACCATGGGGACAGACTCACTGAGGACTCACAACCTCATCCTTCTGCGCGGGGGCCCGTCCCTGGG


GTGGAAGACATTCTTGAATCTTCACTGGGCACTAACTGGGTCCTAGAAGAAGCTTCTGGAGAGGCTAGTGAGGGATTTTTGACCCAG


GAAGCAAAGTTTTCCCCCTCCACGCCTGTAGGGGGCAGCATCCAGGCAGAGACTGACAGACCCAGGGCCCTCTCAGCATCTCCATTC


CCTAAATCAACAGAGGACCAAAAGCCAGTGGATATAACAGACAGGCCGTTGACAGAGGTGAACCCTATGAGACCCATTGGCCAGACA


CAGAATAATACTCCTGAGAAGACTGATGGTACATCCACGCTGCGTGAAGACCACCAGGAGCCAGGCTCTCCCCATATTGCGACACCG


AATCCCCAACGAGTCAGCAACTCAGCCACCCCCGTTGCTCAGTTACTGCTTCCCAAAAGCCACTCTTGGGGCATTGTGCTGCCCCTT


GGGGAGCTTGAGGGCAAGAGAAGTACCAGGGATCGAAGGAGCCCCGCAGAGCTGGAAGGAGGATCAGCAAGTGAGGGGGCAGCCAGG


CCTGTGGCCCGTTTTAATTCCATTCCTTTGACTGACACAGGCCATGTGGAGCAGCATGAGGGATCCTCTGACCCCCAGATCCCTGAG


TCTGTCTTCCACCTGCTGGTGCCGGGCATCATCCTAGTCTTGCTGACTGTTGGGGGCCTCCTGTTCTACAAGTGGAAGTGGAGGAGC


CATCGAGACCCTCAGACATTGGATTCTTCTGTGGGGCGACCAGAGGACAGCTCCCTGACCCAGGATGAGGACAGACAGGTGGAACTG


CCAGTATAGAAAGGATTCTATGACCCCTCACCATCCTGGACACACTCGTTTGTCAATGTCCCTCTGAAAATGTGGCGCCCAGCCCTG


GACACAGTACTCCAGATGTTGTCTGACCAGCTCAGAGTACAGTGGGACGGTTGTCTTCCTTGATCTGGACAGTACTCTTCTACTCGT


GCAGATTAAGATCACATTAGTTTTAACAGCTGCATCATATATTGTCATATGTTGAGCTTGTAGTCTATTAAAAACCCCAGTTCTATT


TCCTGTG





MOUSE PROTEIN SEQUENCE : mP27-014.2 (Seq ID No: 35)


MTARGAAGRCPSSTWLGSRLLLVCLLMSRSIAKEVSEHCSHTHGNGHLKVLQQLIDSQMETSCQIAFEFVDQEQLDDPVCYLKKAFF


LVQDIIDETMRFKDNTPNMJATERLQELSNNLNSCFTKDYEEQNKACVRTFHETPLQLLEKIKNFFNETKNLLEKDWNIFTKNCNNS


FAKCSSRDVVTKPDCNCLYPKATPSSDPASASPHQPPAPSMAPLAGLAWDDSQRTEGSSLLPSELPLRIEDPGSAKQRPPRSTCQTL


ESTEQPNHGDRLTEDSQPHPSAGGPVPGVEDILESSLGTNWVLEEASGEASEGFLTQEAKFSPSTPVGGSIQAETDRPRALSASPFP


KSTEDQKPVDITDRPLTEVNPMRPIGQTQNNTPEKTDGTSTLREDHQEPGSPHIATPNPQRVSNSATPVAQLLLPKSHSWGIVLPLG


ELEGKRSTRNRRSPAELEGGSASEGAARPVARFNSIPLTDTGHVEQHEGSSDPQIPESVFHLLVPGIILVLLTVGGLLFYKWKWRSH


RDPQTLDSSVGRPEDSSLTQDEDRQVELPV*





MOUSE PANTHER CLASSIFICATIONS


FAMILY (SUBFAMILY)


MACROPHAGE COLONY STIMULATING FACTOR-1 (MACROPHAGE COLONY STIMULATING FACTOR-1)





BIOLOGICAL PROCESS


Immunity and defense (2.16.00.00.00) > Macrophage-mediated immunity (2.16.05.00.00)


Immunity and defense (2.16.00.00.00) > Granulocyte-mediated immunity (2.16.04.00.00)


Developmental processes (2.23.00.00.00) > Mesoderm developmemt (2.23.10.00.00) >


Hematopoesis (2.23.10.06.00)





MOLECULAR FUNCTIONS


Signaling molecule (1.02.00.00.00) Cytokine (1.02.01.00.00) > Other cytokine


(1.02.01.99.00)





MOUSE GENE ONTOLOGY


No Gene Ontology





MOUSE PROTEIN DOMAINS (INTERPRO SIGNATURES)


No Domain Hit





MOUSE mRNA SEQUENCE: mR27-014.3 (Seq ID No: 36)


GAAAGTTTGCCTCGGTGCTCTCGGTGTCGCTGCGGCTCTCTGCATCCCAGGACAGCGGCGTGGCCCTCGACCGGGGCGCGGGCTCTT


CAGCCACTAGCGAGCAAGGGAGCGAGCGAACCAGGGCGGCCAACACGCCGTGCCGGGACCCAGCTGCCCGTATGACCGCGCGGGGCG


CCGCGGGGCGCTGCCCTTCTTCGTGGATCCAGGTTCAAATCCCAGAATCTAGATGATGGTTCACAACCATTCATACCTCCAGGTCCA


GGAGATTCCAAGAAGGAAGCACATAGAGTGTGTGCATGCAAGCAGGCAAAATATTCATAAACACAAAACAAAAACAACATGGCTGGG


CTCCCGGCTGCTGCTGGTCTGTCTCCTCATGAGCAGGAGTATTGCCAAGGAGGTGTCAGAACACTGTAGCCACATGATTGGGAATGG


ACACCTGAAGGTCCTGCAGCAGTTGATCGACAGTCAAATGGAGACTTCATGCCAGATTGCCTTTGAATTTGTAGACCAGGAACAGCT


GGATGATCCTGTTTGCTACCTAAAGAAGGCCTTTTTTCTGGTACAAGACATAATAGATGAGACCATGCGCTTTAAAGACAACACCCC


CAATGCTARCGCCACCGAGAGGCTCCAGGAACTCTCCAATAACCTGAACAGCTGCTTCACCAAGGACTATGAGGAGCAGAACAAGGC


CTGTGTCCGAACTTTCCATGAGACTCCTCTCCAGCTGCTGGAGAAGATCAAGAACTTCTTTAATGAAACAAAGAATCTCCTTGAAAA


GGACTGGAACATTTTTACCAAGAACTGCAACAACAGCTTTGCTAAGTGCTCTAGCCGAGGCCATGTGGAGCAGCATGAGGGATCCTC


TGACCCCCAGATCCCTGAGTCTGTCTTCCACCTGCTGGTGCCGGGCATCATCCTAGTCTTGCTGACTGTTGGGGGCCTCCTGTTCTA


CAAGTGGAAGTGGAGGAGCCATCGAGACCCTCAGACATTGGATTCTTCTGTGGGGCGACCAGAGGACAGCTCCCTGACCCAGGATGA


GGACAGACAGGTGGAACTGCCAGTATAGAAAGGATTCTATGCTGGGCACACAGGACTATCTCTTTATGGAAGGAGACATATGGGAAC


ATCCACCACTACCCTCTCCTACCATCTTCCTGGGAATGTGGCCTACCACTACCAGAGCTCCTGCCTACCAAGACTGGATGAAAGAAG


CAGCTTTGATGGGGTCTTTCCATCCTCACCCTTAGACTCTCAACCAAAGAGAAAGGGCTGGAGGATGCCCCCCACATACTGCCACTA


TTTATTGTGGGCCCTGGAGGCTCCCTGCATTGGAGGAAGGGCAGCTCAGCAGCTCAGGACCCTTTCCCTTAGGGGCTGCTTCCTCCC


CTCAAAACCAGAACCTGGCAAGGGACTCACTAGCCTGGATGGCCCATGGGAGACCAGGACAGATGAGAAGGAGCAGAAGAGCCCTGT


GCCCAGAAGACCCAACTGGTGCCAAGGAATCCCAGCATGGACAGGCAGGGACCTGTTTCCCAAGAAGAGAGCCTGATATTCAAAGGG


TGGGACAGCATCTGC





MOUSE PROTEIN SEQUENCE: mP27-014.3 (Seq ID No: 37)


MMVHNHSYLQVQEIPRRKXIECVHASRQNIHKHKTKTTWLGSRLLLVCLLMSRSIAKEVSEHCSHMIGNGHLKVLQQLIDSQMETSC


QIAFEFVDQEQLDDPVCYLKKAFFLVQDIIDETMRFKDNTPNANATERLQELSNNLNSCFTKDYEEQNKACVRTFHETPLQLLEKIK


NFFNETKNLLEKDWNIFTKNCNNSFAKCSSRGHVEQHEGSSDPQIPESVFHLLVPGIILVLLTVGGLLFYKWKWRSHRDPQTLDSSV


GRPEDSSLTQDEDRQVELPV*





MOUSE PANTHER CLASSIFICATIONS


FAMILY (SUBFAMILY)


MACROPHAGE COLONY STIMULATING FACTOR-1 (MACROPHAGE COLONY STIMULATING FACTOR-1)





BIOLOGICAL PROCESS


Immunity and defense (2.16.00.00.00) > Macrophage-mediated immunity (2.16.05.00.00)


Immunity and defense (2.16.00.00.00) > Granulocyte-mediated immunity (2.16.04.00.00)


Developmental processes (2.23.00.00.00) > Mesoderm development (2.23.10.00.00) >


Hematopoesis (2.23.10.06.00)





MOLECULAR FUNCTIONS


Signaling molecule (1.02.00.00.00) > Cytokine (1.02.01.00.00) Other cytokine


(1.02.01.99.00)





MOUSE GENE ONTOLOGY


No Gene Ontology





MOUSE PROTEIN DOMAINS (INTERPRO SIGNATURES)


No Domain Hit





MOUSE mRNA SEQUENCE: mR27-014.4 (Seq ID No: 38)


TGAAAGTTTGCCTCGGTGCTCTCGGTGTCGCTGCGGCTCTCTGCATCCCAGGACAGCGGCGTGGCCCTCGACCGGGGCGCGGGCTCT


TCAGCCACTAGCGAGCAAGGGAGCGAGCGAACCAGGGCGGCCAACACGCCGTGCCGGGACCCAGCTGCCCGTATGACCGCGCGGGGC


GCCGCGGGGCGCTGCCCTTCTTCGACATGGCTGGGCTCCCGGCTGCTGCTGGTCTGTCTCCTCATGAGCAGGAGTATTGCCAAGGAG


GTGTCAGAACACTGTAGCCACATGATTGGGAATGGACACCTGAAGGTCCTGCAGCAGTTGATCGACAGTCAAATGGAGACTTCATGC


CAGATTGCCTTTGAATTTGTAGACCAGGAACAGCTGGATGATCCTGTTTGCTACCTAAAGAAGGCCTTTTTTCTGGTACAAGACATA


ATAGATGAGACCATGCGCTTTAAAGACAACACCCCCAATGCTAACGCCACCGAGAGGCTCCAGGAACTCTCCAATAACCTGAACAGC


TGCTTCACCAAGGACTATGAGGAGCAGAACAAGGCCTGTGTCCGAACTTTCCATGAGACTCCTCTCCAGCTGCTGGAGAAGATCAAG


AACTTCTTTAATGAAACAAAGAATCTCCTTGAAAAGGACTGGAACATTTTTACCAAGAACTGCAACAACAGCTTTGCTAAGTGCTCT


AGCCGAGATGTGGTGACCAAGCCTGATTGCAACTGCCTGTACCCTAAAGCCACCCCTAGCAGTGACCCGGCCTCTGCCTCCCCTCAC


CAGCCCCCCGCCCCCTCCATGGCCCCTCTGGCTGGCTTGGCTTGGGATGATTCTCAGAGGACAGAGGGCAGCTCCCTCTTGCCCAGT


GAGCTTCCCCTTCGCATAGAGGACCCAGGCAGTGCCAAGCAGCGACCACCCAGGAGTACCTGCCAGACCCTCGAGTCAACAGAGCAA


CCAAACCATGGGGACAGACTCACTGAGGACTCACAACCTCATCCTTCTGCGGGGGGGCCCGTCCCTGGGGTGGAAGACATTCTTGAA


TCTTCACTGGGCACTAACTGGGTCCTAGAAGAAGCTTCTGGAGAGGCTAGTGAGGGATTTTTGACCCAGGAAGCAAAGTTTTCCCCC


TCCACGCCTGTAGGGGGCAGCATCCAGGCAGAGACTGACAGACCCAGGGCCCTCTCAGCATCTCCATTCCCTAAATCAACAGAGGAC


CAAAAGCCAGTGGATATAACAGACAGGCCGTTGACAGAGGTGAACCCTATGAGACCCATTGGCCAGACACAGAATAATACTCCTGAG


AAGACTGATGGTACATCCACGCTGCGTGAAGACCACCAGGAGCCAGGCTCTCCCCATATTGCGACACCGAATCCCCAACGAGTCAGC


AACTCAGCCACCCCCGTTGCTCAGTTACTGCTTCCCAAAAGCCACTCTTGGGGCATTGTGCTGCCCCTTGGGGAGCTTGAGGGCAAG


AGAAGTACCAGGGATCGAAGGAGCCCCGCAGAGCTGGAAGGAGGATCAGCAAGTGAGGGGGCAGCCAGGCCTGTGGCCCGTTTTART


TCCATTCCTTTGACTGACACAGGCCATGTGGAGCAGCATGAGGGATCCTCTGACCCCCAGATCCCTGAGTCTGTCTTCCACCTGCTG


GTGCCGGGCATCATCCTAGTCTTGCTGACTGTTGGGGGCCTCCTGTTCTACARGTGGARGTGGAGGAGCCATCGAGACCCTCAGACA


TTGGATTCTTCTGTGGGGCGACCAGAGGACAGCTCCCTGACCCAGGATGAGGACAGACAGGTGGAACTGCCAGTATAGAAAGGATTC


TATGCTGGGCACACAGGACTATCTCTTTATGGAAGGAGACATATGGGARCATCCACCACTACCCTCTCCTACCATCTTCCTGGGAAT


GTGGCCTACCACTACCAGAGCTCCTGCCTACCAAGACTGGATGAAAGAAGCAGCTTTGATGGGGTCTTTCCATCCTCACCCTTAGAC


TCTCAACCAAAGAGAAAGGGCTGGAGGATGCCCCCCACATACTGCCACTATTTATTGTGGGCCCTGGAGGCTCCCTGCATTGGAGGA


AGGGCAGCTCAGCAGCTCAGGACCCTTTCCCTTAGGGGCTGCTTCCTCCCCTCAAAACCAGAACCTGGCAAGGGACTCACTAGCCTG


GATGGCCCATGGGAGACCAGGACAGATGAGAAGGAGCAGARGAGCCCTGTGCCCAGAAGACCCAACTGGTGCCAAGGAATCCCAGCA


TGGACAGGCAGGGACCTGTTTCCCAAGAAGAGAGCCTGATATTCAAAGGGTGGGACAGCATCTGCCCGACTTCCCGTAAAGGCATAA


AGGCACGCAGCCCAAAAGACGGGAAGAGGAGGCCTTTGGCTGCTTGTGTTGACAGCTTAAAGGGGTCTACACCCTCAACTTGCTTAA


GTGCCCTCTGCTGATAGCCAGGAAGGAGGGAGACCAGCCCTGCCCCTCAGGACCTGACCTGGCTCATGATGCCAAGAGGAAGACAGA


GCTCTAGCCTCGTCTTCTCCTGCCCACAGCCCCTGCCAGAGTTCTTTTGCCCAGCAGAGGCACCCCTCATGAAGGAAGCCATTGCAC


TGTGAATACTGAACCTGCCTGCTGAACAGCCTGTCCCATCCATCCCTATGAGTGACCATCCGTCCGAATGTTCTCCCACTTCCTTCA


GCCTCTCCTCGGCTTCTTGCACTGAGCTGGCCTCACGTGTTGACTGAGGGAGCCCCTGAGCCCCAACCTTCCCCTGCCTCAGCCTTT


GATTGTCCAGGGTGAAGCTGTGGGAGAACCGCCTGGGCTACCAGTCAGAGCTGGTCTTTGGGCTGTGTTCCTTGCCCAGGTTTCTGC


ATCTTGCACTTTGACATTCCCAGGAGGGAAGTGACTAGTGGAAGGGAGAGAGGAAGGGGAGGCAGAGACAAAGGCCACAGGCAGAGC


TATGAATGAGAATGGGTCTTGAAAATATGTGTGCACCCCTAAGCTTGAAATTGATCTCTATACTCTAGCCCCTCAGCCAGCCTCCTT


CCTGTTGTCTGAAACCTGGAGCTAAGCAGGTTGTCCTGTCACAAGCTCTGGGGACTGAGCTCCATGCTCCAACCCCACCCTCTTCTG


ACCTTTGTTCTCCAGACCTGACCCAGGTAGGCAAGGGTACCCTCCCAGTCTCACCTACCATACTGTGCCATCTCTAGCCAAGCAAGC


CAGGTTTAGAGAAGGGTCAAAAAAAAAAAAAAGGGTTGTTTACTTCCAACTTGTTCTGATGCCCTCTGTTTCCCAGGCCAGGCTTGT


CTGTGGTGACCTGGGCATGGGTGACAGGGCTCTCATTTGCCCCTTGGTCTCTTTATGCTGCTGAGTCCCCCTTTCCTGCCCTCCCTG


GCTACTGGGTCAATAATCTTTCAGGCCATGAATCTGGGAGGAGAGTGGTCTGTAAGCTCCATCAGCCCTGTCCTGAGACAGCAGGGG


GGAAGGACACTGGAGACTTTCTTGTGGGGCTTACTTAGCCTTCTGGTTACAGACTATTTCCATGCTAGAAAATACATATTTTAAAAT


AGAAGGAAAAACACAGAAACAAAACAAAACAAGGCATTCTCTACCCCTCCACCTTAAACATATATTATTAAAGACAGAAGAGAAAAT


CCAACCCATTGCAAGAAGCTCTTTGTGGGTGCCTGGTTACATCGGAGCAGGGGAGCCTCAAATCCACCTTTGGAGCCGCCCCTGTGT


GCATTAGGAACCCTTCTCTCCTCTGAGAAAGCTCAGAGGGAGCACTGCCTCACAAACTGTGAGACTGCGTTTTTTATACTTGGAAGT


GGTGAATTATTTTATATAAGGTCATTTAAATATCTATTTAAAAAATAGGAAGCTGCTTTTATATTTAATAATAAAAGAAGTGCACAA


GCTGC





MOUSE PROTEIN SEQUENCE: mP27-014.4 (Seq ID No: 39)


MTARGAAGRCPSSTWLGSRLLLVCLLMSRSIAKEVSEHCSHMIGNGHLKVLQQLIDSQMETSCQIAFEFVDQEQLDDPVCYLKKAFF


LVQDIIDETMRFKNTPNANATERLQELSNNLNSCFTKDYEEQNKACVRTFHETPLQLLEKIKNFFNETKNLLEKDWNIFTKNACNNS


FAKCSSRDVVTKPDCNCLYPKATPSSDPASASPHQPPAPSMAPLAGLAWDDSQRTEGSSLLPSELPLRIEDPGSAKQRPPRSTCQTL


ESTEQPNHGDRLTEDSQPHPSAGGPVPGVEDILESSLGTNWVLEEASGEASEGFLTQEAKFSPSTPVGGSIQAETDRPRALSASPFP


KSTEDQKPVDITDRPLTEVNPMRPIGQTQNNTPEKTDGTSTLREDHQEPGSPHIATPNPQRVSNSATPVAQLLLPKSHSWGIVLPLG


ELEGKRSTRDRRSPAELEGGSASEGAARPVARFNSIPLTDTGHVEQHEGSSDPQIPESVFHLLVPGIILVLLTVGGLLFYKWKWRSH


RDPQTLDSSVGRPEDSSLTQDEDRQVELPV*





MOUSE PANTHER CLASSIFICATIONS


FAMILY (SUBFAMILY)


MACROPHAGE COLONY STIMULATING FACTOR-1 (MACROPHAGE COLONY STIMULATING FACTOR-1)





BIOLOGICAL PROCESS


Immunity and defense (2.16.00.00.00) > Macrophage-mediated immunity (2.16.05.00.00)


Immunity and defense (2.16.00.00.00) > Granulocyte-mediated immunity (2.16.04.00.00)


Developmental processes (2.23.00.00.00) > Mesoderm development (2.23.10.00.00) >


Hematopoesis (2.23.10.06.00)





MOLECULAR FUNCTIONS


Signaling molecule (1.02.00.00.00) > Cytokine (1.02.01.00.00) >


Other cytokine (1.02.01.99.00)





MOUSE GENE ONTOLOGY


No Gene Ontology





MOUSE PROTEIN DOMAINS (INTERPRO SIGNATURES)


No Domain Hit





HUMAN GENOMIC SEQUENCE: hD27-014 (Seq ID No: 40)


TTGGGACGATCATAGAGCGCTAGCACTGAATCAGCCTGGAGAGCGCGGAAGGAAAGGGTCGGTCCGCAGAGGGCGCGGGGAAGGCAG


GGTGGGGACGCGGTGGAGCCCGCGCTCGTTTGCTGAAGGCTTGGAAGTGCAGCGCAGAAGACAGAGGGTGACTAGGAAGACGCGCGA


GCGGGGCTGGCCGGCCGGCGGGTGGGGGAGGGGAGGCGGGGGAAGGCGGCTGAGTGGGCCTCTGGAGTGTGTGTGTCTGTGTCAGTG


TGTGTGTGTGTGTGTGTATGTGTGTGTCTGGCGCCTGGCCAGGGTGATTTCCCATAAACCACATGCCCCCCAGTCCTCTCTTAAAAG


GCTGTGCCGAGGGCTGGCCAGTGAGGCTCGGCCCGGGGAAAGTGAAAGTTTGCCTGGGTCCTCTCGGCGCCAGAGCCGCTCTCCGCA


TCCCAGGACAGCGGTGCGGCCCTCGGCCGGGGCGCCCACTCCGCAGCAGCCAGCGAGCGAGCGAGCGAGCGAGGGCGGCCGACGCGC


CCGGCCGGGACCCAGCTGCCCGTATGACCGCGCCGGGCGCCGCCGGGCGCTGCCCTCCCACGGTAAGCGACGGCCGCGGCGCTGGGC


CCGGGACGGGCTGGGGCGGGGGCTCGGCGGCCAGGCGGCCGGGAGCGGCCCCTCGGAGCCGACAGCCTGGGCGCGCCGGCTGCACTG


GCCCGGCGTTCCCGCCGCGGACGAACCGCCTTTGCGCACGGACTGGGCCCTGGCGCCAGGGCGGAGGCCGGTGGCGGCCCTGCAGCT


GCACCGGGACTGCCAGGCTTCCCTGGGAAACGGAGGGCTGCTCACCCCATTGCACGGAGGGGAACACTGAGCCACCTGCAGGCAGGA


GCCCCCGCTCAGCCAGGGTGCCCTGCCTCTCTCCCTANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGCTGC


TTGGGGCTAGCTCAGAATCTCTTTTTCTTGCAAATTCTGGTTTCATCGGTTGGGGAGATTCTGGGCTTTGTGGTGGTTTATGGTGGT


TTGCAGTGCTTGAGGAAAATGGAAAGAGGGTTTGGTGTTGCAGAGCTGTGTCCAGGGGCAGGGTCTGCTCCTGACTGCGTAAGGGAC


GCCCTGCCCCAACTGTGGCGGTAGCAGATGCAGCCATAGAAAGTGAGGGTGGCACTGTTCATGACCAGTCAGTGGGCTCATAATAGA


TTTGCTTCTGAGGAGTCCTGGAAGAAAATGAGAGGGGAAACCTGGGGGGAAAAGAGCAGAAAATTATTTGGGGGTAGAGGAGAGCGG


GCTGCAGGTGAGGTGAGAGAGAAAGGGAAGAGTGGGTCCACAGAAAGAAAGTGCCTCACTGAGAGAGAGGAGATAGAGTTGAGAGGG


GAAGGGAGAAGGGTTAGCCATAGGCAGAAAGCAAAGCTTCGGGGCTGAAGGGGAGACCATGAGGAAAGAAGAGAAAGACAAGGGGGC


TGTGTTTAGACAGGGGAAGTCCAAGGGCCCGGTTCTGCCAGGTCTCTCCAGAGGCCTTGTTGAGGGGGAAGATGAAATGGAATAGGA


TAGGTGGCAGAGGAGGCTGGACAGCTGGACTGAGGTGTCCTAGCATCTCTGAGCCTGCAGCAGAGATTCCTTCTGAGGGCTGCTCCC


CAGGCAGAAGCCAGGGCTAGGGGTGGGAGGAAGAGGCAGTCAGAGGAGAGCCTGCCCAGCCAGATGCAAGCCAGAGTGTTAACCCCC


CACTGTCTGTCCAGATCCTCCTGAGGCAGAATGGAGGCCCCAGGTCCAGGGGTATCCCCTTTGGCCAGCTTCGAAGTCAGCCTCTCA


TGTAGTGGCTGCACTTTCCCCACACTGATGCCTCAAATGTCATCAAAGCCAGACAGCCCTTGGGGTTAAGCATTGCTCCCACCTTGC


TCTCCTCCAGGGAGGTTGTCTTCCTGAGCGGTCCCTTTCATCCATACCATTCACTCCAGACCTTGAGTGGCAGCCAGTCTGGGGTAG


ATACACCGTCTAGTGGCCCAGTTTCCTCCAATCATTCCTGARCCTAAGGTTTCTGAGTACCTGGGCCATTATTCCCACCCAGGGCAA


CCTCCCCAACAGAGCCTGAAGTCCCCCCAGCCCCCGTGACTGCCGTCCCCCTCTTCCACACTTTCCCTCCCTCAGATCAGCCAGGAT


CCTCACAGTCCCTGTGCTGAGTGGTATGAAACTATCCTTTGGCTCTTCCTTCCATGGCTCCCACCCCTCTCCTGCCATCACCTTCTC


CCCATCTTTCAAGGCCTCACTGAGGTCCCTGCTCTCTGCAGTCTCCCTGGTCACCCAGCCAGAGCTGCCTTCTCCTCCCCAGAAGAG


CTGGCAAGCATTTGGGCTTTTGGTGATATGTAGATTAGCACATTGTTGTGGGCTGTTTCATAGCCTCGTTGTGTTTTTCCAGTGAGC


AACTTATTTGCAGTATTTGTCTCAACATCTGGATTATTGAGGCAAAACCCAGAGTCCAGGATAGTGTCAACCTTCACCCTACCCTGC


CAGCATTTCCCTGAATCTGGGGGCATCAGCCGCCAGGAGGCTTGGGAGCTCTCAGGAGGTGACCTCAAGCTGGAGAAAGAAAGCCCA


AGAGTCTGTCTGCTTTTGGCTGAAGAAGGAGAGACCTAGGGCCACGGGTAGCGATGAGGAGACCCCAGTGAAGAGAAGGAAGAGAGG


AAGGAAGGGGAAAGACAGGGCATCAGGAGCCAGTCCCATCACTCTGGGGCTGAGCAACTACTGGGCCAGGTAGGTGCTGGGAGAGAA


GAGGGGTCTCAGAAAACTTCTCTGCCATGATAAGAGGTGGCTGGCTGGAGGCAAAGCCTGATGGTGCTCAAATAGGCAGGTGCCAGG


CAAGGGATGGCCCATTACTGGCACTGGTGCCTCTGATTAATCAGCTGGGCTCCTTTTGAAACACACACCCAGGGCTCCAAGATGTCT


CTGGCAAGGGATGAGTTCCAGTGAAACTGAGTTTGATCCCACAGTTTTTCCAGTGGCAGAGCCAGATCTGCATGGAACCAGGTGGGA


GGAAATGCTGGGCCCAGGGGAGCTGTCTCTGGCTTGCCATCTGAAAGCCGGTGCATGAACATGAACTTGAGGGCAGTTCAAAAAGTG


CTTGGCTCAGTGTTGATGTTGCAGAGACAGAAAAAAATGGGTAGATGCAAGTCCTGCTCTCGAGTTTCCTGTGTCATTAAAATTTAG


GCTGGTAGGCCACCATCTGTGTCAGTATTAGTTCAATGTATAGTTAGGTTTGGCTGGCTTAATCTGGGAAGGCTTACTTGTAGAAGG


TGACATCTGGGTTGTTTTCATGGGAGAACAAGGTTGTGCTGTGGCTGCTAGAAATCCTGGGAAAGCTGGATTTGAGGGATGCTGTAT


CCTGAGGTAAGGGGCAGAGCCTGTAGCATTGTAGATATGAGGCCTTTGTTTTTCTGCGTTGAGCAGGGCATGGGGATAACTGGGGAG


AGTGAGACCTGGGGAGAAATGACACCCTCTCTGTCACAGACATGGCTGGGCTCCCTGCTGTTGTTGGTCTGTCTCCTGGCGAGCAGG


AGTATCACCGAGGAGGTGTCGGAGTACTGTAGCCACATGATTGGGAGTGGACACCTGCAGTCTCTGCAGCGGCTGGTGAGTGTGTGG


CCATGCTGTATTCTACCTTCTCCCCACTGGGGAAATGAAGGCAGGAGCCAGGGAGCAGGTCAAAGAGAGCAGTTGCAGGCAGGAAAA


TAGGGCAGTGCGGGACATTGCTTGTGGTTCCCACTAGCTCCACCAGTGATACCCTTCACTAACCTTCCCAAAGTTAGGACCTCTGGT


CTCCCCAGCTCGAAGCCCTCTCTGACTGCCCTGCAGGCAGTGGATGCTGTGGGCTTCCAGCTGCTTGCCTGGGTTAGTGATTGCCCA


GGAACATCAACCACTGATTCTGAAAAGGCTTCTGAGGTCTGCTGTCCCTCAGTGGGATGCCTCCTCTGGGAAGCTAGCCCAGGCGGC


CTGCTGTGTCCAGATGTTGCATCTAGCTCCTGGACTCTCATATGTGGCGCCAGTCTGGCATCAGAGCCCCACCCAGATTTGGAGGGG


AAGCGCTTGCCTAACTCCCAGCCTTCCACACTCACTTCCCTGGCTCTTGCCCATACCCTGAGGCTGGGATGGCCTGCTCATCTGGGC


CATGAAGGAGCCTGTATCTCATTCTAATCAGACCCATACGTGGTCCAGCCAGGCAGAATCAGGTTGCTGTCATGGCTGCTGTCCTGC


TCAGTGGGAATTTACCATTCCTCTGGCCAGCCAGGCAGGGTGGGGCATCACTGGCTAACGCCAGCTCCAGGGCCCTGAGCTTGGGGC


CTGTGGGCTGTGCCTTCCGCCTCTCTTGCCCCAGCACTACTTCTCCTGTATGTAGTTGCTGTAGCAATCCAAGGTAGACCAAGAGCC


CCAGCATTCTCTGAGGCTTAAAATCCAGAACTGCTGCTCTGGGGCTAAAGAGGGCTTTAAGGGCATCCAGCTCCAACCCCTACAGGT


GTTCAATCCCCAGAGCTTGTCCAGCCTCTGCTTGAATTCCTACCATGACAGGGTGCTCACTGCCTCCAGGGAAGATTATATCCTATA


TTCTTCTATAGACATCTCTTCCTTAAAACAAATGGGCATTTGTCAGATTTCGTGGGGTGGTAGAAGGAAAGAAGAGACTTCTTGTTC


TTCTACAGCCTTCCCCTGGGCATCTGGAAGGCACTGATCTTCTCCTAGACTTGACTCTGTCTTTCCACGTGTGGTTGGCAGGGATGA


AGTTCAAACCCCAATCCACTCAGAAGCTAAGGTCCCCGTTTTGAAGAAGGCTGAAGGCTGAGTTGAGCTGTAGGTTACCCTGCAATC


GTTGGCCTGCTCTCTCTTACAGATTGACAGTCAGATGGAGACCTCGTGCCAAATTACATTTGAGTTTGTAGACCAGGAACAGTTGGT


GAGTGATGGCTTTTTACAAAATCCATGCACCAGCCTGCATGCAACTCCCAGGGTGGGGTGTGTGGGGGAGCATGAAAGCGGCAGAAT


GCCTACTGCTGGAAAGGGTGAGAGTGTGAGGATCCATGGGTGCTCAACTCTGGGGTGCCAGGATCCAGGGCTCAAGTCCCCTGCCAT


TCCCTTCTCCTGGCCTGATACATAACAAGCGCTCACTAGGTACCAAGCACTTTGCTAATGTAGTTCTGACAGTACCACTATGTGGTA


CACAAATACAGTTTATTATCCACAGAGAGGTGAAAGGAGCATAGCTAGTAGGTGCTAGAGGCCTGATTTGAATCCAGGAAGGTTGGC


TGTAGGGCTTGAGGCAAATCAATACTTCTTCCAGGTCACAAGCTTTGCTTAAGGATGTCACTTCTCTTCACCAGGCCAACCAGCAGG


CAGGTAGGCAGTCCAGCCCTTCCTGGACTTGCCCCACACCCAACCAGCCACCAAGTGCTGCTGGTTCTGCCTCTCAGCATCTCTGGG


TTCTGTCTCCTCCATCCCCACCTTCACCCCTCAATCAGTTGCTTGGACAATTTCAAGAGCCTCCTAACTGGTGTCTCCCTGCTTTCT


AGTTCACTCCTCATCTTACCACTGGGGGAAATTTTCTGAAACGCCAACCTGCTGCCTTTACCTCCTTCTCCCAAAAACATCAGGGCC


CCCATCACTCCAGAAGAAAGCCAAGGTTGTCTAGTCTGGGTTACACCAGGTCTAGCCATTCTCCACCACACAAGCCTCTATACCACC


TCCCCATTCCCTGCTTCTTCCTGCCTCCCATCTTTGCACAAGCTCTTTCCAATGACTGTCATGCCTTTCCACCTGCCCCCCAATCAT


TATTCCACATCTATTCATCTTTATGCCTCATGCAAAACTGCCTTGATACCCAGAAGTTGCCCCTGTTTCTGAGCTTCCACACACCTG


ACCCATATGCACCTCTGTTAGGACTAGAGATCACCTCATGGTCCAAAGAATAGCCTCAGTATTTTATGCACTCACTCGCTTGCTCTA


GCACTCATGCCTGAACTAGCATTTGCTACGAACCTACTGGACTAGATGCTGGGGGTAGAGAGCTAAAGCAGAGTGGGTCTTCAAGGC


AACTACCATCTCTTTAGGGAGACAAAACACAGAGGTTATTCTTTGGACCATGAGATAGTCTTCAGCACCCCTATGTCCTGGAGGATT


TGAAGGCGCCATATGGTAAAAGATATTTGTGAAAGCAAGACAAGAGGAAGACAGAAAGAAAGGCAGGGGAAGGTTCCCTGGAGCCCA


CCTTCCCTATATACATCCATCGTGATTAAAGCCTCATATTCCAGAAACCCAGAGAACTCTCTAATCAGAATCCACATTTCCTTCACT


CTAGCCCAGTCTCCAGTGGCGCTAGATCCCAAAGAGAGAGAAAGACAGGCAAGCTGAGGGCGGCATTCTCCTAGTTGCTGGCATGGT


GTGGTCCCTCCCCTGGGGGAAGGGGGAGAGCAAGCTGCAACCCTCCATCTGCCTGGGGTTGGGGGTTCCCAGGCCACAATGGCCAGG


CCATAAGCTCCAGGTTCCTGTTTTTCAGAAAGATCCAGTGTGCTACCTTAAGAAGGCATTTCTCCTGGTACAAGACATAATGGAGGA


CACCATGCGCTTCAGAGATAACACCCCCAATGCCATCGCCATTGTGCAGCTGCAGGAACTCTCTTTGAGGCTGAAGAGCTGCTTCAC


CAAGGATTATGAAGAGCATGACAAGGTAGGAAGCCCTGAGGCCTGGAGCACTGAGTGAGGGCAGAGGGTGGCTGTGGAGGCGCCGCT


CTATCCACAGGCACAGAGTACATTCGCTCACCTCGCCTCACGCCATTGCTTGCTCACTCTCATTTATTTGTCATCCCACCAACCTTT


ACCAGGCAGGAGGCAGGAGGGATCATGCTGGGCCCTGACAATGTCATCATGAGCAACAAATACATGGTCCCACCCCATGCAGCTTAT


AGTCAAGTGAGCTTGGCAGCTGTTAAACACCATGACACCAGTAAATAGAATTACAAACTATAAGGACTGTTCATTCCAACAGCAAAA


GCAGTTATTGTGTGTCTGTTGTGTACCAGACACTGTTCTAGACACCAGGAAACAGCTGTGATGAAAACAGACAAAAATCCCCACATT


CCTGGAACTTACATTTGGGGGTGATGGTAGTGGTGGTGAGACAGTTAACAAAATATGTAAGTAAAATATACAACATGTAGCATGGCA


ATAACAGCACTGGAGAAGAGTAACCAGGGATGAGACGACCCGAAGGAAGTGGAGGAGTGAGCTCGGAACAAGAACCTGAAAGGGCTC


AAGGAGAGCAACAGGGAACTCAGACTTCCATGGAGTTGGGGAAGCAGAGACAAGAAAGGCTTCTGAGTAAGCAAATATTGATTTGAG


CTCCAAAGATGAGTAAGAATTGAAAGCAGTAAGGCTAGAAGAACATTCTGGAACAGGAAAAGCTATGCACAAAGCCCTAAGGTAAAC


AAACAGGAAAGTGCACATTCAGGGACCCAAAGGGTTATCAGCATGGCCAGAGCATGGGAAGTGAAGGAGGGGGAGGACAGAAGTCAG


GAGCCAGATCACATGTCGTTTTAGAGATGTGGGATTTTGTCTTAAGGGTGAGGGAAGCTGTTGTGAACAGGCATGTGGCTTAATCTC


AGGTTATAAGACTGACCTGGTTGCTATGTGGAGGATAGACCACAGGGGGCAGGAATGGAGGCTGGGAGACCAGCAGAAGGTGTGAGT


CCAGGCTAGACACATTGGCGGCTTGGACCAAGGTGGGACAGTGAAGGTGGAGGCAAGTGGACTGGACATGTTCCCGTGGGTTTAGGG


GCAGAATCAACAAGACTTGGTACGTGCAGTGGATGTGAGAAGCTGAGGGAAAGAAAAAGCCAAGGATGGTTTTTGTCTTGAGCACCT


GGATATTCCAATGATGCTGAAACGGGGATGATCCATGGGCAGAGCAGGTTTGAGGGAAGACAGTTCAGTCTGGGGCACAGCAGACGT


GAGGTGCTCATGAAATGGTGAGTGGAGACGTTGAGGAGGCAGCTAGGTGTGCGGGTCTTGAGTGTGACCAGCAATGCACAGATCTAT


GAGGCATGGGGGTTCGGCTTATCTGTGAAGCCATGGGACTGGACAGCACTCCCACTGTGAGAAGAGAAGCAGGCCCAGGAACCCAGC


ATTTGGAGGGCAAGCAGAGGATGGGGGACCTGGCAAGGGGCAGCCTGAAGGTGGGAGGAAAAGAGGGAGAGTGCAGAGTCGAGGCAC


TGCATTCCAAGATGGATAAGGGATGGAAATTCATAAAAAAGCGTTGAGAAATCAAGCAAGGTGAGGGCTAAAATTGTCCATTGGATT


TGGCAACGTGTCACACATGCTGGATCAGGGTGAACAGAAAGAGAGGAAGTAGAGACACCACTGTGGAAGAACTTGGATCCGAATGGG


GGCAGGAAAAGAGATGTAGCTGGAGGGAGTGTGTAATTGAGGGAGGACTTTTTGTTCTGTTTTTGTTGTCGTTGTTTTGAGACAGGG


TCTCATTCTGTCACCCAAGCTGAAGTTCAGCGGCGCAATCACGACTCACTGCAGCCCAACCTCCCAGGCTCAATTGATCCTCTGACT


TCAGTCTCCTGAGTAGCTGGGACAACAGGCACACCCCACTATGCCCAGCTATTTTTTGTAGAGATAGGGTTTCGCAATGTTGCCCAG


GCTGGTCTCAAACTCCCAGGCTCAAGCAATCTGTCTGCCTTGGCCTCCCAGAGTGCTGGGATTACAAATGTGAGTTACTGTGCCTGG


CCAGGAAAACATTTTTAATAAGAGAGGTATTAAATCTGCGGTTTTCCAACATTAAGATTCCTAAGAATCACTTGGGGAATGTGTTGA


AAATGCATATTCCTAGGACACACCCCTAGAGAGTCTGATACACTGGGTTTAAGAGTGGCTCCAGGGCCGGGCGCGGTGGTTCATGCC


TCTAATCCTGGCACTTTGGGAGGCCGAGACAGTGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGCCCAACAGGGCGAAACCCC


CCATCTTACTAAAAATACAAAAATTAGCAGCTGGTGGTGGCGCATGCCTGTAATCCAAGCTACTCGCGAGGCTGAGGCAGTAGAATC


GCTTGACCCAGGGTGGCGGAGGTTGCAGTGAGCTGAGATCGAAACTCCATCTCAAAATAAATAAATAAATAAATAAATAAATAAATA


AATAAATAAATAAATAAAAGACTGAACCCAGGAATCTGCATCTTAAGCAGCTGTCGCACTGATGATTATGACCCCCTTGGATATTCA


CTTGTAGACATGTGTGAATGCTGAGGGGCAGGCTCCAAGAGAGAGGGTGGGTGAAGCTGGAGGAGCTAGCTCCCAGCAAGTCTCTGG


AGAAGACAGTGGGAGGGATTCAGAGCTCCTGAGGGAGAGTGAGAGTCAGACTTCATCTCAAAAAAAAAAAAAATGTTTACCAGATAG


ACGTACGAATGAGAAGACTGGGCTCAGCTCCATCACTTACCAGCTAGGTGGCAGTGACCAAGTAAACTGCCGGAGTCTCACTCTCTC


CCAGGCTGGAGTGCAGTAGTGCCATCTCAGCTCACTGCAACCTTTGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAG


TAGCTGGGATTACAGGCACGCACCACCATGCCCAGCTAATTTTTGTCTTTCTAGCTGGGATTACAGGCACGTGCCACCATGCCTGGC


TAATTTTTGTCTTTTTAGTAAAGACAAGGTTTCACCATGTTGGTCAGGCTGATCTCCAACTCCTGACCTCGTGATCAGCCTGCCTCG


GCCTCCCAACATGCTGGGATTACAGGTGTGAGCCACCGCACCCGGCCTATCTGGTAAACATTTCTTAAGGGCTGACTGCATAGGCCA


GGGAGATGCGGCGATGCCTTCAAGGACTTCACAGCCTAGAAAAGCCCATGTTTCTTCCCTGTGAAGCTCAGTTTAAGGAAAAACTTG


GTATCTGTGATTCAGTGGCATTTAGGCCCTGGATGAAGCTGTGAGCATGCATGGCATGGCCTTGTGTGAAAGGAGAGGTGGGCCCGG


GAGTGAACCCTGAGGGATGGCAGCATTTGGATATCAGGAGGAGAAGGGGAGCTTGGTAAGGAGACAGAAAGAGCAGCTTGAAAGGTG


GGAGAAGACCCAGGATGATGCAGCTTCTCAGAGCTCCAGTGGGTGTGGGAAGCCGGGGCCCCTTGAGCAGCACAGAAGACAGGGCTG


GGACCTCCTCAGCCCTCCCTCTAAGACACACCAATGCCAGCAAAGGACCCATATGCCTGGCGGCTGCCCCGTTCCCTTCTCCACACC


ACAGCTCAATGATTTTTCTCAAACTCAACTCTTACCATGCCACTGCCCACCCCTAACACCCCTTCAGATGTTTTCCCTTTGCTCTGT


GGACAAAACTAAAAGTTCTGGTCTTGGCCCACGAGGCCCTCAAGACCTGGCCCTTGCTAACCTCTCTCCTTGTGCGTCTCTTGCCAC


GCTCCTCCTAGATGGTAGTGCTGCAGCCACACCAGCCTTCTTTTAGTCTTTGGGCTTTTCATGCATTTTCTTGCCTCAGGACTTTTG


CACGGTCTGTTCTTGCAGCCTGGACAGCTCTCTGGGATCCCATCTCTTTCCTGGTTTCTCTTGCTCATCTTTTAGTTGATTCCTTGG


GGAAATTCTCCCTGAACACTTGTTTAGTTCCCCTTGTTGCACACCATCGGATGGCCCAGTACTTATTCATAGGACTCATTGCACTTG


TAACAATGTGTTTAGTCCCTGCTGGATTGCTGGACTCACTGTCCAACTCAGCCAGGAACCACCTCTCTCTTGTTCGTTGCATGATTC


CCAGGTAATTACCATATGCCTGGCACATAAACATATGTTGAATGGGTCTGTGAATAAATGACATATCTCATAACCTCAGGACTCATT


CTGCTGCAAACCAGGGGAAAGGGGAGCAAGGAAACAAAAGGGAAAAAGAAGACAGATGTGAGAAAGGCCAAGGGAATTTGACAAATA


AGATGGAGACATGGGGCCAATGGTCATGCTCACAAAAGGGGGCCCTGATCTCCTTCCAGGCCTGCGTCCGAACTTTCTATGAGACAC


CTCTCCAGTTGCTGGAGAAGGTCAAGAATGTCTTTAATGAAACAAAGAATCTCCTTGACAAGGACTGGAATATTTTCAGCAAGAACT


GCAACAACAGCTTTGCTGAATGCTCCAGCCAAGGTAAGCATGGCAGGGGCCAGCAAGTGTGTGGGGGTGGTAGCATATGGAATGGGG


ATTGGGAGGTGAGATGTGAAGCTGGGGGGACCCCTGGGGAGGCAGCCTGGCTGCTACTCGTGTTCCCGTGTGCATGAATGTGCTTGT


TCTGTGTATATATGTGGCTTCACGTACCTCTGGTCCTGGGCACATGTCTTTTCTGACATGTGTGTGCATGCACACCTACATATGTCT


GCATGTGGCAGCGTCAAGAAGGATCATGCTGGTGCCTTGAGATTAGGGAGTGGAAATGGGAGCCTGTCTTGGGAGCCCTGTAGGTAT


GGAAGCTTTCCCCACTGGCTCTGCAGGCTGGCTGAACGTGTGGGGGGTTCTGTGGAGACAGCTGACACCCATCTGGCAGTCAGGGCC


CTTGCTCCAGGAGCTCTGCTGCGAATCACCATGATACCCTGGCTCCAGAAGTCCCCAGGATGCCTTGGCTGTTTCCTCAAGGGACAA


GGCTGGATTTGAAGTCTGAGCATCATTGGAACTCCCAGGGCTGGCTCAGCTGCATACATGTGTACACTGCGTGTCCTCGTCTCTGCG


TCTCGTGCCACACGTGCCCTCCTACATTCAACCTTGCTTCCCAAGGCAGGGTCTAGGGCCCTGCAACCTGCCAGTGGCCAAGTCCAG


TCTCGTTGCTTCAATCCCAAGTCCTCAAGCCTTGGCTGCATTCTAGCCCCAGCCTGTTCCTGCCTGTGGCTGTGGCTGTGGCTGTGG


CTGTGTGGCTCCTGGCTATGCATGAAACCAGTGTCTCTGGGGCTTGAAGTTGTCTTGTATTGGTCTGGAAGGCAACCGTTCAGCCTC


CTGACCTGACTGCTGCTCACCCCTAGCTTGGCCTGTGGCCAGTGGGAACCCCTGCATGGGCTGTTCTCTTATCTTCCTTCTCCCCAA


CCCCCAGTGTGTGCATCTCAACCCTATTCTTTGTCACTGCTCATGAGACCCTGCATACGGCACCTTCCCTGTGTCATGAGCACCCAC


TCTAGTCCCATCCTCTTCTCAGCCCCAGGGCTGAGCTAGGAGATGAGGGCCCCCCAGACTCACATTCCCCTCTTGCCCCGCTCTGGG


AAAGCTGTGCTGGAGGCTAGTGACTCTATCTCCTCCCCATCTTTCTCTCTCCTTCTCTCTGTGGTTCTTTCAGATGTGGTGACCAAG


CCTGATTGCAACTGCCTGTACCCCAAAGCCATCCCTAGCAGTGACCCGGCCTCTGTCTCCCCTCATCAGCCCCTCGCCCCCTCCATG


GCCCCTGTGGCTGGCTTGACCTGGGAGGACTCTGAGGGAACTGAGGGCAGCTCCCTCTTGCCTGGTGAGCAGCCCCTGCACACAGTG


GATCCAGGCAGTGCCAAGCAGCGGCCACCCAGGAGCACCTGCCAGAGCTTTGAGCCGCCAGAGACCCCAGTTGTCAAGGACAGCACC


ATCGGTGGCTCACCACAGCCTCGCCCCTCTGTCGGGGCCTTCAACCCCGGGATGGAGGATATTCTTGACTCTGCAATGGGCACTAAT


TGGGTCCCAGAAGAAGCCTCTGGACAGGCCAGTGAGATTCCCGTACCCCAAGGGACAGAGCTTTCCCCCTCCAGGCCAGGAGGGGGC


AGCATGCAGACAGAGCCCGCCAGACCCAGCAACTTCCTCTCAGCATCTTCTCCACTCCCTGCATCAGCAAAGGGCCAACAGCCGGCA


GATGTAACTGGTACCGCCTTGCCCAGGGTGGGCCCCGTGAGGCCCACTGGCCAGGACTGGAATCACACCCCCCAGAAGACAGACCAT


CCATCTGCCCTGCTCAGAGACCCCCCGGAGCCAGGCTCTCCCAGGATCTCATCACTGCGCCCCCAGGGCCTCAGCAACCCCTCCACC


CTCTCTGCTCAGCCACAGCTTTCCAGAAGCCACTCCTCGGGCAGCGTGCTGCCCCTTGGGGAGCTGGAGGGCAGGAGGAGCACCAGG


GATCGGAGGAGCCCCGCAGAGCCAGAAGGAGGACCAGCAAGTGAAGGGGCAGCCAGGCCCCTGCCCCGTTTTAACTCCGTTCCTTTG


ACTGACACAGGCCATGAGAGGCAGTCCGAGGGATCCTCCAGCCCGCAGCTCCAGGAGTCTGTCTTCCACCTGCTGGTGCCCAGTGTC


ATCCTGGTCTTGCTGGCCGTCGGAGGCCTCTTGTTCTACAGGTGGAGGCGGCGGGTGAGTAGATCCCCATGAGGAAGAAGAGCACGT


CCCTTAGGGCAGGGGCAGAGCCTGGCGGGGGTGCAGGTGGGGGGACAGCTTGGGTGCGGCCTGAGTTCTTCAGACACAGAGAGATAG


GGGCTGGCTCAGCACAGAGGATGAGAGGTGGAAATGGAGGATTACTTCGAGATTGGGAAGGTTCAAGCTATAAGGTCAATGGGAAAG


GGACTGGAGCAGAAGGGAGCGGGAGAGAATATTCATGGGCTGACAGCAGGATGATATCCAGACGGGCAGGGAGCTGGAGGAGGAGAG


CAATGCTGTGTGAGCGTGTCAGGGCAGGCGTACACTCGAAGCTCTGCAGAGCCTGGGGCAGGAGGACCCATAGGGAACAGCCTGCAA


GGGTGTGGGGAGAGGAGAGGGGACACCATCAGCAGAGAGACCTCACAAATCTCCCTTGGGCCTCTGGCTGATCCCCACTTTTGGGAA


GTTGGGAGGACTCTTGCAACTCTCTCATAAATACCTGGGGCAGCCCTTACTGGGGATGGGCCACCGCCCCCCCACACTCCCCCAGCT


CCTCAGTGAGATGCTCTTTCCTGTCCTCAGAGCCATCAAGAGCCTCAGAGAGCGGATTCTCCCTTGGAGCAACCAGAGGGCAGGTGA


GAGCTTGAGGTGGGGCTCTGGGAGGCACTGGGGGCCTGGCTTGGGATCTGTTTCCCCTCTTCGTGGTGGTGGGGCTCTCCTGCTTGC


TCTGAGGAAATGGAGCTGCAGAACAGGATGGGGGAGAGAAGAAGGGCCTCTGTCCTTTCCCAGATATCTGGGCTTTTTCCTGATTTC


TCCGTAGAGTTAGACAGTTCTGGGTCTTTTCAATCTGACAGGGCCTAGAGCATGTCTGGGGCTTAGGGGTAAACTTACGGAGTCCCC


TTATTCCCCTGCTCCTGCTGATGTCTAATGCCAGCCCTGTGCTCTGCCTGCAGCCCCCTGACTCAGGATGACAGACAGGTGGAACTG


CCAGTGTAGAGGGAATTCTAAGGTAAGATTCTGACTTTGATCTCCACTCCTAAAACTTACCTATACCCTTTTCCAGTCACGTTCACC


TGTTGGTGACACCAATTCCCCTGAGGCCCCCACACTGACTCCCATGCCTCTCTCCAGTTCCCTTTCCATACATCGCCAGCCAGGTCC


AGCCACCCTCTCCTTTCCAGGTCCTCAGCTATCCCCCTGCCCCTCCATTCCATCCACCCCCGCTGAGGCCAGGGACTATTACCTCTG


CATTGGGCTTCTAGTGTTGCTGCCACCTGTGACCTCAGAGCAACTAAACCCCCCTTTTTCAAATGTGGCCTTTATAAGGTCTTTACC


CTCCTGGAGAATCTTCAGTAGCTCTGTGTGGCAGCCACTGCAAGCCCTATATTCTTGGCTTGGCTGCCAAGCCCCTTCGACAGCAGC


TGCTTGCCAGATCGCCACCCCCGCACCAGTTAACCCTCCTCCCCAGCTGAGGTCAGTTCTGCTTCCTTGCTTTTAGGATCATGTTGA


CATAGAACCTGAGTCTTGGAAGGGCTCTCAGCGGTCATTTGGCCCTGGTTCCCACCCCAAAGGGACTGCCCCTCTCCATGTCCCCAA


CAGGGAGCCAGCCAGCTGGCTGTCACACACTCCCAGATCCAGCCCAGCTCCCTGCCTAGCCACAGCCCATGCCATCTTCCAGTCAGA


CTGGGAGAAACGTCTTCCTCATGCGAGGCAAAACTGGCTTCCCTGCCCCCTCCATACTGCTCCTCCCTCCTGTTCTCATGAAAACCC


TCAGATATTTCAAGTCAGGTATCCATGTCCCCTTTGAGAATTCTCTAAGCTAAGTATGGCCAAGTCCCTCAAACGTTCCTTATATGA


TATGGTTTTCAGACCCCTCACCATCCTGGACACACTCGTTTGTCAATGTCCCTCTGAAAATGTGACGCCCAGCCCCGGACACAGTAC


TCCAGATGTTGTCTGACCAGCTCAGAGAGAGTACAGTGGGACTGTTACCTTCCTTGATATGGACAGTATTCTTCTATTTGTGCAGAT


TAAGATTGCATTAGTTTTTTTCTTAACAACTGCATCATACTGTTGTCATATGTTGAGCCTGTGGTCTATTAAAACCCCTAGTTCCAT


TTCCCATAAACTTCTGTCAAGCCAGACCATCTCTACCCTGTACTTGGACAACTTAACTTTTTTAACCAAAGTGCAGTTTATGTTCAC


CTTTGTTAAAGCCACCTTGTTGGTTTCTGCCCATCACCTGAACCTACTGAAGTTGTGTGAAATCCTAATTCTGTCATCTCCGTAGCC


CTCCCAGTTGTGCCTCCTGCACATTGATGAGTGCCTGCTGTTGTCTTTGCCCATGTTGTTGATGTAGCTGTGACCCTATTGTTCCTC


ACCCCTGCCCCCCGCCAACCCCAGCTGGCCCACCTCTTCCCCCTCCCACCCAAGCCCACAGCCAGCCCATCAGGAAGCCTTCCTGGC


TTCTCCACAACCTTCTGACTGCTCTTTTCAGTCATGCCCCTCCTGCTCTTTTGTATTTGGCTAATAGTATATCAATTTGCACTTATT


TGGATGTTGTTTTCATATTTTTTAAAATCTTATTTTATATGTATTGTACATTCCACATCCCTAAGATTGTAAGCCCCTTGAGGGCAG


GGACTGTCTTCCACTTTTTTTTGTGTTTCTTTTTCCATCCTGGGTTCTACTAAGAGAGGGCCTCTCCACATTTGCCAAACATGCAAT


AAATGTTGACTGACTGGCTTCAGGGCTGACTCACGGACTGACCCTGGCCAGCTGTCTCTAACTGACCAGCCTCTAGCTGACCAGTTA


ACCAGCTAACTGACTGACTCTGACTGACTGGCTGACCAGCTGGCTGGGTGAATGACTAACCAACCAACTATCTTGGTAACTGCCTAA


CTGACCAGCTGTTGCTTGGGGAGCCCATTGAGCAACTGACTAGCTGATTGCCTGACTAATTGGCTGGTTGGCTGACTAGCTGGGGTG


ACCCAGTCAAGTTTCCAGTCACATCCTTTACCAAGTGCAAGCCAGTGCCGCAGGGCTCTCCCATGTGTGGAGTGACAGGTCTGGGCC


CCTTCTAGAGAGATAGGGAATTTGGCAAATGCTCAAAACCAGGGGAACCTATTTAGACAAGAACCAGCAGTAACAACATATCTGGAA


TCCTGGGGTCTACCTTGTCAGTGGGGTGGGCTAAGATGGGTGAGTGGGTCAGCTGGGGCACTGGCAAGACTGTGAAATGACCCAGGC


CTCCTCAGAACTGGTTGCTGGTGGCTCAGTGCCACAACACCCTTCCCACTGGTCGTCTGTCCCCAAACCCCTCGCCGTGGTCTTGGC


CCTCTGTCCCACCCCTCTACACGCCCACCCTCCTTTCCCCACTTGCTTATTCTCAGGCCCGTCCCAAGCTTTCCTCTTCCCCCTCAA


GATTTCACTTGGAGAGGGAATCCAGGGCAGGGGCTACATCCAGATCCCACTTGGCCCGGCAGGTCCAGCCCTAAGGTGGTCTCCAGG


CCAGGCACCAGTGGCCTTGGAGAGATTGAGTGCCAGCCCCTAGAGTGACTGCTGCTGTGATTTGAGAAGTGAGAGAGAGAAACATAG


AGGCAGAGACTGAGATAGGGACTCAGAGCCACAGAAAATGCAGACACCAGCACCTCAGCCCTAAGCAGCTAGAAGATGGGGCAGCAG


GCTGGAACTCGCTCACTGGGTCCTTCTCCCCTCCTGGGCCCTAGCTGGGCCTGTGGCCTGGCTGTACCCAGCATGGCTCATGTCCAG


TTTATGGTTCCCCTTCTTTCCCTCTAGAGCATGGGAATGGGCAGGGAGCCAGAGGCTGTGGTTCCATCTTCCCTCCTTACCCAGTAG


GGCCTATGGATGTTAGGGAGGGAGGCTCCACACAAGGTCCAAAGTCAAACTGTTGGATGGGGTCCAGGGGATTTCTGCTCTGGGAAC


AAAGCGTCCTGAGGATGCTGGGCAAGAGGACAAGGATGGGGGTGGAAGGCGAGAGGACAAGGCCCTGACTCCCATGGATGATGCGGG


AGGCAAGGCCCTCGGCCCATCCAGGAGGGGCTGGGTTGCTTAGGGGTCGCGTGCCAAATGACAGTGTGGGAATTTCCTTGTCCTGGC


ACTGCCTCTAGACTTTTCCTCTCTGGCCCAAGTTGTTCCTCTTCAGCTAGCTCTGCCCTACTGTCTTGAACATCATATGTGATGCCC


CTCTGATGAAATGAAAGATTCTTCTTTGCTAGTGTTAGCAGGAATCACCCTTTGTTCACTGGACCAAGGCCAATGAGATGACCTCGC


CTGAGGAGGGGTCCAAAGACATTCAAGTGCCCGCTTCGCTCCTTGTCAGAGCCCTCTGCTTGAGCAGTAACCCCTCTTCCCAGCCCT


GCCCAGACCCCTCCCGGGCCCCGTTATCTTCCACTGAGGCCCTGATTCCCCAGGAGGAGGTAGGAGGTGAGGCCAGTTGGGCCAGAG


GCCTGGGCTGGTGCCAGAGAAAGCTGCCTGGTCTCTCTGTGGTGTCTGGAAAGGCCAGGGAAGGGAGGAAAGGAAGTCCTGCCTGCA


GCACCGCCAGCAGCCCACAGGAATGCCACACCTCCCAATCCATGTCCTCAACGACCCTCCCCGCATTCCCACTCTGCTGACTAGCCT


TTCCTTCTCTCCCACAGCTGGACGCACAGAACAGTCTCTCCGTGGGAGGAGACATTATGGGGCGTCCACCACCACCCCTCCCTGGCC


ATCCTCCTGGAATGTGGTCTGCCCTCCACCAGAGCTCCTGCCTGCCAGGACTGGACCAGAGCAGCCAGGCTGGGGCCCCTCTGTCTC


AACCCGCAGACCCTTGACTGAATGAGAGAGGCCAGAGGATGCTCCCCATGCTGCCACTATTTATTGTGAGCCCTGGAGGCTCCCATG


TGCTTGAGGAAGGCTGGTGAGCCCGGCTCAGGACCCTCTTCCCTCAGGGGCTGCACCCTCCTCTCACTCCCTTCCATGCCGGAACCC


AGGCCAGGGACCCACCGGCCTGTGGTTTGTGGGAAAGCAGGGTGGACGCTGAGGAGTGAAAGAACCCTGCACCCAGAGGGCCTGCCT


GGTGCCAAGGTATCCCAGCCTGGACAGGCATGGACCTGTCTCCAGAGAGAGGAGCCTGAAGTTCGTGGGGCGGGACAGCGTCGGCCT


GATTTCCCGTAAAGGTGTGCAGCCTGAGAGACGGGAAGAGGAGGCCTCTGGACCTGCTGGTCTGCACTGACAGCCTGAAGGGTCTAC


ACCCTCGGCTCACCTAAGTGCCCTGTGCTGGTTGCCAGGCGCAGAGGGGAGGCCAGCCCTGCCCTCAGGACCTGCCTGACCTGCCAG


TGATGCCAAGAGCGGGATCAAGCACTGGCCTCTGCCCCTCCTCCTTCCAGCACCTGCCAGAGCTTCTCCAGGAGGCCAAGCAGAGGC


TCCCCTCATGAAGGAAGCCATTGCACTGTGAACACTGTACCTGCCTGCTGAACAGCCTGCCCCCGTCCATCCATGAGCCAGCATCCG


TCCGTCCTCCACTCTCCAGCCTCTCCCCAGCCTCCTGCACTGAGCTGGCCTCACCAGTCGACTGAGGGAGCCCCTCAGCCCTGACCT


TCTCCTGACCTGGCCTTTGACTCCCCGGAGTGGAGTGGGGTGGGAGAACCTCCTGGGCCGCCAGCCAGAGCCGGTCTTTAGGCTGTG


TTGTTCGCCAGGTTTCTGCATCTTGCACTTTGACATTCCCAAGAGGGAAGGGACTAGTGGGAGAGAGCAAGGGAGGGGAAGGGCACA


GACAGAGAGGCTACAGGGCGAGCTCTGACTGAACATGGGCCTTTGAAATATAGGTATGCACCTGAGGTTGGGGGAGGGTCTGCACTC


CCAAACCCCAGCGCAGTGTCCTTTCCCTGCTGCCGACAGGAACCTGGGGCTGAGCAGGTTATCCCTGTCAGGAGCCCTGGACTGGGC


TGCATCTCAGCCCCACCTGCATGGTATCCAGCTCCCATCCACTTCTCACCCTTCTTTCCTCCTGACCTTGGTCAGCAGTGATGACCT


CCACTCTCACCCACCCCCTCTACCATACCTCTAACCAGGCAAGCCAGGGTGGGAGAGCAATCAGGAGAGCCAGGCCTCAAAGCTTCC


AATGCCTGGAGGGCCTCCACTTTGTGGCCAGCCTGTGGTGGTGGCTCTGAGGCCTAGGCAACGAGCGACAGGGCTGCCAGTTGCCCC


TGGGTTCCTTTGTGCTGCTGTGTGCCTCCTCTCCTGCCGCCCTTTGTCCTCCGCTAAGAGACCCTGCCCTACCTGGCCGCTGGGCCC


CGTGACTTTCCCTTCCTGCCCAGGAAAGTGAGGGTCGGCTGGCCCCACCTTCCCTGTCCTGATGCCGACAGCTTAGGGAAGGGCAGT


GAACTTGCATATGGGGCTTAGCCTTCTAGTCACAGCCTCTATATTTGATGCTAGAAAACACATATTTTTAAATGGAAGAAAAATAAA


AAGGCATTCCCCCTTCATCCCCCTACCTTAAACATATAATATTTTAAAGGTCAAAAAAGCAATCCAACCCACTGCAGAAGCTCTTTT


TGAGCACTTGGTGGCATCAGAGCAGGAGGAGCCCCAGAGCCACCTCTGGTGTCCCCCCAGGCTACCTGCTCAGGAACCCCTTCTGTT


CTCTGAGAAGTCAAGAGAGGACATTGGCTCACGCACTGTGAGATTTTGTTTTTATACTTGGAAGTGGTGAATTATTTTATATAAAGT


CATTTAAATATCTATTTAAAAGATAGGAAGCTGCTTATATATTTAATAATAAAAGAAGTGCACAAGCTGCCATGTGAGT





HUMAN mRNA SEQUENCE: hR27-014.1 (Seq ID No: 41)


CCTGGGTCCTCTCGGCGCCAGAGCCGCTCTCCGCATCCCAGGACAGCGGTGCGGCCCTCGGCCGGGGCGCCCACTCCGCAGCAGCCA


GCGAGCGACTGCCCGTATGACCGCGCCGGGCGCCGCCGGGCGCTGCCCTCCCACGACATGGCTGGGCTCCCTGCTGTTGTTGGTCTG


TCTCCTGGCGAGCAGGAGTATCACCGAGGAGGTGTCGGAGTACTGTAGCCACATGATTGGGAGTGGACACCTGCAGTCTCTGCAGCG


GCTGATTGACAGTCAGATGGAGACCTCGTGCCAAATTACATTTGAGTTTGTAGACCAGGAACAGTTGAAAGATCCAGTGTGCTACCT


TAAGAAGGCATTTCTCCTGGTACAAGACATAATGGAGGACACCATGCGCTTCAGAGATAACACCCCCAATGCCATCGCCATTGTGCA


GCTGCAGGAACTCTCTTTGAGGCTGAAGAGCTGCTTCACCAAGGATTATGAAGAGCATGACAAGGCCTGCGTCCGAACTTTCTATGA


GACACCTCTCCAGTTGCTGGAGAAGGTCAAGAATGTCTTTAATGAAACAAAGAATCTCCTTGACAAGGACTGGAATATTTTCAGCAA


GACTGCAACAACAGCTTTGCTGAATGCTCCAGCCAAGATGTGGTGACCAAGCCTGATTGCAACTGCCTGTACCCCAAAGCCAATCCC


TAGCAGTGACCCGGCCTCTGTCTCCCCTCATCAGCCCCTCGCCCCCTCCATGGCCCCTGTGGCTGGCTTGACCTGGGAGGACTCTGA


GGGAACTGAGGGCAGCTCCCTCTTGCCTGGTGAGCAGCCCCTGCACACAGTGGATCCAGGCAGTGCCAAGCAGCGGCCACCCAGGAG


CACCTGCCAGAGCTTTGAGCCGCCAGAGACCCCAGTTGTCAAGGACAGCACCATCGGTGGCTCACCACAGCCTCGCCCCTCTGTCGG


GGCCTTCAACCCCGGGATGGAGGATATTCTTGACTCTGCAATGGGCACTAATTGGGTCCCAGAAGAAGCCTCTGGAGAGGCCAGTGA


GATTCCCGTACCCCAAGGGACAGAGCTTTCCCCCTCCAGGCCAGGAGGGGGCAGCATGCAGACAGAGCCCGCCAGACCCAGCAACTT


CCTCTCAGCATCTTCTCCACTCCCTGCATCAGCAAAGGGCCAACAGCCGGCAGATGTAACTGGTACCGCCTTGCCCAGGGTGGGCCC


CGTGAGGCCCACTGGCCAGGACTGGAATCACACCCCCCAGAAGACAGACCATCCATCTGCCCTGCTCAGAGACCCCCCGGAGCCAGG


CTCTCCCAGGATCTCATCACTGCGCCCCCAGGGCCTCAGCAACCCCTCCACCCTCTCTGCTCAGCCACAGCTTTCCAGAAGCCACTC


CTCGGGCAGCGTGCTGCCCCTTGGGGAGCTGGAGGGCAGGAGGAGCACCAGGGATCGGAGGAGCCCCGCAGAGCCAGAAGGAGGACC


AGCAAGTGAAGGGGCAGCCAGGCCCCTGCCCCGTTTTAACTCCGTTCCTTTGACTGACACAGGCCATGAGAGGCAGTCCGAGGGATC


CTCCAGCCCGCAGCTCCAGGAGTCTGTCTTCCACCTGCTGGTGCCCAGTGTCATCCTGGTCTTGCTGGCCGTCGGAGGCCTCTTGTT


CTACAGGTGGAGGCGGCGGAGCCATCAAGAGCCTCAGAGAGCGGATTCTCCCTTGGAGCAACCACAGGGCAGCCCCCTGACTCAGGA


TGACAGACAGGTGGAACTGCCAGTGTAGAGGGAATTCTAAGCTGGACGCACAGAACAGTCTCTCCGTGGGAGGAGACATTATGGGGC


GTCCACCACCACCCCTCCCTGGCCATCCTCCTGGAATGTGGTCTGCCCTCCACCAGAGCTCCTGCCTGCCAGGACTGGACCAGAGCA


GCCAGGCTGGGGCCCCTCTGTCTCAACCCGCAGACCCTTGACTGAATGAGAGAGGCCAGAGGATGCTCCCCATGCTGCCACTATTTA


TTGTGAGCCCTGGAGGCTCCCATGTGCTTGAGGAAGGCTCGTGAGCCCGGCTCAGGACCCTCTTCCCTCAGGGGCTGCACCCTCCTC


TCACTCCCTTCCATGCCGGAACCCAGGCCAGGGACCCACCGGCCTGTGGTTTGTGGGAAAGCAGGGTGGACGCTGACGAGTGAAAGA


ACCCTGCACCCAGAGGGCCTGCCTGGTGCCAAGGTATCCCAGCCTGGACAGGCATGGACCTGTCTCCAGAGAGAGGAGCCTGAAGTT


CGTGGGGCGGGACAGCGTCGGCCTGATTTCCCGTAAAGGTGTGCAGCCTGAGAGACGGGAAGAGGAGGCCTCTGGACCTGCTGGTCT


GCACTGACAGCCTGAAGGGTCTACACCCTCGGCTCACCTAAGTGCCCTGTGCTGGTTGCCAGGCGCAGAGGGGAGGCCAGCCCTGCC


CTCAGGACCTGCCTGACCTGCCAGTGATGCCAAGAGGGGGATCAAGCACTGGCCTCTGCCCCTCCTCCTTCCAGCACCTGCCAGAGC


TTCTCCAGGAGGCCAAGCAGAGGCTCCCCTCATGAAGGAAGCCATTGCACTGTGAACACTGTACCTGCCTGCTGAACAGCCTGCCCC


CGTCCATCCATGAGCCAGCATCCGTCCGTCCTCCACTCTCCAGCCTCTCCCCAGCCTCCTGCACTGAGCTGGCCTCACCAGTCGACT


GAGGGAGCCCCTCAGCCCTGACCTTCTCCTGACCTGGCCTTTGACTCCCCGGAGTGGAGTGGGGTGGGAGAACCTCCTGGGCCGCCA


GCCAGAGCCGGTCTTTAGGCTGTGTTGTTCGCCCAGGTTTCTGCATCTTGCACTTTGACATTCCCAAGAGGGAAGGGACTAGTGGGA


GAGAGCAAGGGAGGGGAGGGCACAGACAGAGAGGCTACAGGGCGAGCTCTGACTGAAGATGGGCCTTTGAAATATAGGTATGCACCT


GAGGTTGGGGGAGGGTCTGCACTCCCAAACCCCAGCGCAGTGTCCTTTCCCTGCTGCCGACAGGAACCTGGGGCTGAGCAGGTTATC


CCTGTCAGGAGCCCTGGACTGGGCTGCATCTCAGCCCCACCTGCATGGTATCCAGCTCCCATCCACTTCTCACCCTTCTTTCCTCCT


GACCTTGGTCAGCAGTGATGACCTCCAACTCTCACCCACCCCCTCTACCATCACCTCTAACCAGGCAAGCCAGGGTGGGAOAGCAAT


CAGGAGAGCCAGGCCTCAGCTTCCAATGCCTGGAGGGCCTCCACTTTGTGGCCAGCCTGTGGTGGTGGCTCTGAGGCCTAGGCAACG


AGCGACAGGGCTGCCAGTTGCCCCTGGGTTCCTTTGTGCTGCTGTGTGCCTCCTCTCCTGCCGCCCTTTGTCCTCCGCTAAGAGACC


CTGCCCTACCTGGCCGCTGGGCCCCGTGACTTTCCCTTCCTGCCCAGGAAAGTGAGGGTCGGCTGGCCCCACCTTCCCTGTCCTGAT


GCCGACAGCTTAGGGAAGGGCAGTGAACTTGCATATGGGGCTTAGCCTTCTAGTCACAGCCTCTATATTTGATGCTAGAAAACACAT


ATTTTTAAATGGAAGAAAAATAAAAAGGCATTCCCCCTTCATCCCCCTACCTTAAACATATAATATTTTAAAGGTCAAAAAAGCAAT


CCAACCCACTGCAGAAGCTCTTTTTGAGCACTTGGTCGCATCAGAGCAGGAGGAGCCCCAGAGCCACCTCTGGTGTCCCCCCAGGCT


ACCTGCTCAGGAACCCCTTCTGTTCTCTGAGAAGTCAAGAGAGGACATTGGCTCACGCACTGTGAGATTTTGTTTTTATACTTGGAA


GTGGTGAATTATTTTATATAAAGTCATTTAAATATCTATTTAAAAGATAGGAAGCTGCTTATATATTTAATAATAAAAGAAGTGCAC


AAGCTGCCATGTGAGT





HUMAN PROTEIN SEQUENCE: hP27-014.1 (Seq ID No: 42)


MTAPGAAGRCPPTTWLGSLLLLVCLLASRSITEEVSEYCSHMIGSGHLQSLQRLIDSQMETSCQITFEFVDQEQLKDPVCYLKKAFL


LVQDIMEDTMRFRDNTPNAIAIVQLQELSLRLKSCFTKDYEEHDKACVRTFYETPLQLLEKVKNVENETKNLLDKDWNIFSKNCNNS


FAECSSQDVVTKPDCNCLYPKAIPSSDPASVSPHQPLAPSMAPVAGLTWEDSEGTEGSSLLPGEQPLHTVDPGSAKQRPPRSTCQSF


EPPETPVVKDSTIGGSPQPRPSVGAFNPGMEDILDSANGTNWVPEEASGEASEIPVPQGTELSPSRPGGGSMQTEPARPSNFLSASS


PLPASAKGQQPADVTGTALPRVGPVRPTGQDWNHTPQKTDHPSALLRDPPEPGSPRISSLRPQGLSNPSTLSAQPQLSRSHSSGSVL


PLGELEGRRSTRDRRSPAEPEGGPASEGAARPLPRFNSVPLTNTGHERQSEGSSSPQLQESVFHLLVPSVILVLLAVGGLLFYRWRR


RSHQEPQRADSPLEQPEGSPLTQDDRQVELPV*





HUMAN mRNA SEQUENCE: hR27-014.2 (Seq ID No: 43)


TTGGGACGATCATAGAGCGCTAGCACTGAATCAGCCTGGAGAGCGCGGAAGGAAAGGGTCGGTCCGCAGAGGGCGCGGGGAAGGCAG


GGTGGGGACGCGGTGGAGCCCGCGCTCGTTTGCTGAAGGCTTGGAAGTGCAGCGCAGAAGACAGAGGGTGACTAGGAAGACGCGCGA


GCGGGGCTGGCCGGCCGGCGGGTGGGGGAGGGGAGGCGGGGGAAGGCGGCTGAGTGGGCCTCTGGAGTGTGTGTGTCTGTGTCAGTG


TGTGTGTGTGTGTGTGTATGTGTGTGTCTGGCGCCTGGCCAGGGTGATTTCCCATAAACCACATGCCCCCCAGTCCTCTCTTAAAAG


GCTGTGCCGAGGGCTGGCCAGTGAGGCTCGGCCCGGGGAAAGTGAAAGTTTGCCTGGGTCCTCTCCGCGCCAGAGCCGCTCTCCGCA


TCCCAGGACAGCGGTGCGGCCCTCGGCCGGGGCGCCCACTCCGCAGCAGCCAGCGAGCGAGCGAGCGAGCGAGGGCGGCCGACGCGC


CCGGCCGGGACCCAGCTGCCCGTATGACCGCGCCGGGCGCCGCCGGGCGCTGCCCTCCCACGACATGGCTGGGCTCCCTGCTGTTGT


TGGTCTGTCTCCTGGCGAGCAGGAGTATCACCGAGGAGGTGTCGGAGTACTGTAGCCACATGATTGGGAGTGGACACCTGCAGTCTC


TGCAGCGGCTGATTGACAGTCAGATGGAGACCTCGTGCCAAATTACATTTGAGTTTGTAGACCAGGAACAGTTGAAAGATCCAGTGT


GCTACCTTAAGAAGGCATTTCTCCTGGTACAAGACATAATGGAGGACACCATGCGCTTCAGAGATAACACCCCCAATGCCATCGCCA


TTGTGCAGCTGCAGGAACTCTCTTTGAGGCTGAAGAGCTGCTTCACCAAGGATTATGAAGAGCATGACAAGGCCTGCGTCCGAACTT


TCTATGAGACACCTCTCCAGTTGCTGGAGAAGGTCAAGAATGTCTTTAATGAAACAAAGAATCTCCTTGACAAGGACTGGAATATTT


TCAGCAAGAACTGCAACAACAGCTTTGCTGAATGCTCCAGCCAAGATGTGGTGACCAAGCCTGATTGCAACTGCCTGTACCCCAAAG


CCATCCCTAGCAGTGACCCGGCCTCTGTCTCCCCTCATCAGCCCCTCGCCCCCTCCATGGCCCCTGTGGCTGGCTTGACCTGGGAGG


ACTCTGAGGGAACTGAGGGCAGCTCCCTCTTGCCTGCTGAGCAGCCCCTGCACACAGTGGATCCAGGCAGTGCCAAGCAGCGGCCAC


CCAGGAGCACCTGCCAGAGCTTTGAGCCGCCAGAGACCCCAGTTGTCAAGGACAGCACCATCGGTGGCTCACCACAGCCTCGCCCCT


CTGTCGGGGCCTTCAACCCCGGGATGGAGGATATTCTTGACTCTGCAATGGGCACTAATTGGGTCCCAGAAGAAGCCTCTGGAGAGG


CCAGTGAGATTCCCGTACCCCAAGGGACAGAGCTTTCCCCCTCCAGGCCAGGAGGGGGCAGCATGCAGACAGAGCCCGCCAGACCCA


GCAACTTCCTCTCAGCATCTTCTCCACTCCCTGCATCAGCAAAGGGCCAACAGCCGGCAGATGTAACTGGCCATGAGAGGCAGTCCG


AGGGATCCTCCAGCCCGCAGCTCCAGGAGTCTGTCTTCCACCTGCTGGTGCCCAGTGTCATCCTGGTCTTGCTGGCCGTCGGAGGCC


TCTTGTTCTACAGGTGGAGGCGGCGGAGCCATCAAGAGCCTCAGAGAGCGGATTCTCCCTTGGAGCAACCAGAGGGCAGCCCCCTGA


CTCAGGATGACAGACAGGTGGAACTGCCAGTGTAGAGGGAATTCTAAGACCCCTCACCATCCTGGACACACTCGTTTGTCAATGTCC


CTCTGAAAATGTGACGCCCAGCCCCGGACACAGTACTCCAGATGTTGTCTGACCAGCTCAGAGAGAGTACAGTGGGACTGTTACCTT


CCTTGATATGGACAGTATTCTTCTATTTGTGCAGATTAAGATTGCATTAGTTTTTTTCTTAACAACTGCATCATACTGTTGTCATAT


GTTGAGCCTGTGGTCTATTAAAACCCCTAGTTCCATTTCCCATAAACTTCTGTCAAGCCAGACCATCTCTACCCTGTACTTGGACAA


CTTAACTTTTTTAACCAAAGTGCAGTTTATGTTCACCTTTGTTAAAGCCACCTTGTTGGTTTCTGCCCATCACCTGAACCTACTGAA


GTTGTGTGAAATCCTAATTCTGTCATCTCCGTAGCCCTCCCAGTTGTGCCTCCTGCACATTGATGAGTGCCTGCTGTTGTCTTTGCC


CATGTTGTTGATGTAGCTGTGACCCTATTGTTCCTCACCCCTGCCCCCCGCCAACCCCAGCTGGCCCACCTCTTCCCCCTCCCACCC


AAGCCCACAGCCAGCCCATCAGGAAGCCTTCCTGGCTTCTCCACAACCTTCTGACTGCTCTTTTCAGTCATGCCCCTCCTGCTCTTT


TGTATTTGGCTAATAGTATATCAATTTGCACTTATCTGGACGCACAGAACAGTCTCTCCGTGGCAGGAGACATTATCGGGCGTCCAC


CACCACCCCTCCCTGGCCATCCTCCTGGAATGTGGTCTGCCCTCCACCAGAGCTCCTGCCTGCCAGGACTGGACCAGAGCAGCCAGG


CTGGGGCCCCTCTGTCTCAACCCGCAGACCCTTGACTGAATGAGAGAGGCCAGAGGATGCTCCCCATGCTGCCACTATTTATTGTGA


GCCCTGGAGGCTCCCATGTGCTTGAGGAAGGCTGGTGAGCCCGGCTCAGGACCCTCTTCCCTCAGGGGCTGCACCCTCCTCTCACTC


CCTTCCATGCCGGAACCCAGGCCAGGGACCCACCGGCCTGTGGTTTGTGGGAAAGCAGGGTGGACGCTGAGGAGTGAAAGAACCCTG


CACCCAGAGGGCCTGCCTGGTGCCAAGGTATCCCAGCCTGGACAGGCATGGACCTGTCTCCAGAGAGAGGAGCCTGAAGTTCGTGGG


GCGGGACAGCGTCGGCCTGATTTCCCGTAAAGGTGTGCAGCCTGAGAGACGGGAAGAGGAGGCCTCTGGACCTGCTGGTCTGCACTG


ACAGCCTGAAGGGTCTACACCCTCGGCTCACCTAAGTGCCCTGTGCTGGTTGCCAGGCGCAGAGGGGAGGCCAGCCCTGCCCTCAGG


ACCTGCCTGACCTGCCAGTGATGCCAAGAGGGGGATCAAGCACTGGCCTCTGCCCCTCCTCCTTCCAGCACCTGCCAGAGCTTCTCC


AGGAGGCCAAGCAGAGGCTCCCCTCATGAAGGAAGCCATTGCACTGTGAACACTGTACCTGCCTGCTGAACAGCCTGCCCCCGTCCA


TCCATGAGCCAGCATCCGTCCGTCCTCCACTCTCCAGCCTCTCCCCAGCCTCCTGCACTGAGCTGGCCTCACCAGTCGACTGAGGGA


GCCCCTCAGCCCTGACCTTCTCCTGACCTGGCCTTTGACTCCCCGGAGTGGAGTGGGGTGGGAGAACCTCCTGGGCCGCCAGCCAGA


GCCGGTCTTTAGGCTGTGTTGTTCGCCCAGGTTTCTGCATCTTGCACTTTGACATTCCCAAGAGGGAAGGGACTAGTGGGAGAGAGC


AAGGGAGGGGAGGGCACAGACAGAGAGGCTACAGGGCGAGCTCTGACTGAAGATGGGCCTTTGAAATATAGGTATGCACCTGAGGTT


GGGGGAGGGTCTGCACTCCCAAACCCCAGCGCAGTGTCCTTTCCCTGCTGCCGACAGGAACCTGGGGCTGAGCAGGTTATCCCTGTC


AGGAGCCCTGGACTGGGCTGCATCTCAGCCCCACCTGCATGGTATCCAGCTCCCATCCACTTCTCACCCTTCTTTCCTCCTGACCTT


GGTCAGCAGTGATGACCTCCAACTCTCACCCACCCCCTCTACCATCACCTCTAACCAGGCAAGCCAGGGTGGGAGAGCAATCAGGAG


AGCCAGGCCTCAGCTTCCAATGCCTGGAGGCCCTCCACTTTGTGGCCAGCCTGTGGTGGTGGCTCTGAGGCCTAGGCAACGAGCGAC


AGGGCTGCCAGTTGCCCCTGGGTTCCTTTGTGCTGCTGTGTGCCTCCTCTCCTGCCGCCCTTTGTCCTCCGCTAAGAGACCCTGCCC


TACCTGGCCGCTGGGCCCCGTGACTTTCCCTTCCTGCCCAGGAAAGTGAGGGTCGGCTGGCCCCACCTTCCCTGTCCTGATGCCGAC


AGCTTAGGGAAGGGCAGTGAACTTGCATATGGGGCTTAGCCTTCTAGTCACAGCCTCTATATTTGATGCTAGAAAACACATATTTTT


AAATGGAAGAAAAATAAAAAGGCATTCCCCCTTCATCCCCCTACCTTAAACATATAATATTTTAAAGGTCAAAAAAGCAATCCAACC


CACTGCAGAAGCTCTTTTTGAGCACTTGGTGGCATCAGAGCAGGAGGAGCCCCAGAGCCACCTCTGGTGTCCCCCCAGGCTACCTGC


TCAGGAACCCCTTCTGTTCTCTGAGAAGTCAAGAGAGGACATTGGCTCACGCACTGTGAGATTTTGTTTTTATACTTGGAAGTGGTG


AATTATTTTATATAAAGTCATTTAAATATCTATTTAAAAGATAGGAAGCTGCTTATATATTTAATAATAAAAGAAGTGCACAAGCTG


CCATGTGA





HUMAN PROTEIN SEQUENCE: hP21-014.2 (Seq ID No: 44)


MPPSPLLKGCAEGWPVRLGPGKVKVCLGPLGARAALRIPGQRCGPRPGRPLRSSQRASERARAADAPGRDPAARMTAPGAAGRCPPT


TWLGSLLLLVCLLASRSITEEVSEYCSHMIGSGHLQSLQRLIDSQMETSCQITFEFVDQEQLKDPVCYLKKAFLLVQDIMEDTMRFR


DNTPNAIAIVQLQELSLRLKSCFTKDYEEHDKACVRTFYETPLQLLEKVKNVFNETKNLLDKDWNIFSKNCNNSFAECSSQDVVTKP


DCNCLYPKAIPSSDPASVSPHQPLAPSMAPVAGLTWEDSEGTEGSSLLPGEQPLHTVDPGSAKQRPPRSTCQSFEPPETPVVKDSTI


GGSPQPRPSVGAFNPGMEDILDSAMGTNWVPEEASGEASEIPVPQGTELSPSRPGGGSMQTEPARPSNFLSASSPLPASAKGQQPAD


VTGHERQSEGSSSPQLQESVFHLLVPSVILVLLAVGGLLFYRWRRRSHQEPQRADSPLEQPEGSPLTQDDRQVELPV*





HUMAN mRNA SEQUENCE: hR21-014.3 (Seq ID No: 45)


TTGGGACGATCATAGAGCGCTAGCACTGAATCAGCCTGGAGAGCGCGGAAGGAAAGGGTCGGTCCGCAGAGGGCGCGGGGAAGGCAG


GGTGGGGACGCGGTGGAGCCCGCGCTCGTTTGCTGAAGGCTTGGAAGTGCAGCGCAGAAGACAGAGGGTGACTAGGAAGACGCGCGA


GCGGGGCTGGCCGGCCGGCGGGTGGGGGAGGGGAGGCGGGGGAAGGCGGCTGAGTGGGCCTCTGGAGTGTGTGTGTCTGTGTCAGTG


TGTGTGTGTGTGTGTGTATGTGTGTGTCTGGCGCCTGGCCAGGGTGATTTCCCATAAACCACATGCCCCCCAGTCCTCTCTTAAAAG


GCTGTGCCGAGGGCTGGCCAGTGAGGCTCGGCCCGGGGAAAGTGAAAGTTTGCCTGGGTCCTCTCGGCGCCAGAGCCGCTCTCCGCA


TCCCAGGACACCGGTGCGGCCCTCGGCCGGGGCGCCCACTCCGCAGCAGCCAGCGAGCGAGCGAGCGAGCGAGGGCGGCCGACGCGC


CCGGCCGGGACCCAGCTGCCCGTATGACCGCGCCGGGCGCCGCCGGGCGCTGCCCTCCCACGACATGGCTGGGCTCCCTGCTGTTGT


TGGTCTGTCTCCTGGCGAGCAGGAGTATCACCGAGGAGGTGTCGGAGTACTGTAGCCACATGATTGGGAGTGGACACCTGCAGTCTC


TGCAGCGGCTGATTGACAGTCAGATGGAGACCTCGTGCCAAATTACATTTGAGTTTGTAGACCAGGAACAGTTGAAAGATCCAGTGT


GCTACCTTAAGAAGGCATTTCTCCTGGTACAAGACATAATGGAGGACACCATGCGCTTCAGAGATAACACCCCCAATGCCATCGCCA


TTGTGCAGCTGCAGGAACTCTCTTTGAGGCTGAAGAGCTGCTTCACCAAGGATTATGAAGAGCATGACAAGGCCTGCGTCCGAACTT


TCTATGAGACACCTCTCCAGTTGCTGGAGAAGGTCAAGAATGTCTTTAATGAAACAAAGAATCTCCTTGACAAGGACTGGAATATTT


TCAGCAAGAACTGCAACAACAGCTTTGCTGAATGCTCCAGCCAAGGCCATGAGAGGCAGTCCGAGGGATCCTCCAGCCCGCAGCTCC


AGGAGTCTGTCTTCCACCTGCTGGTGCCCAGTGTCATCCTGGTCTTGCTGGCCGTCGGAGGCCTCTTGTTCTACAGGTGGAGGCGGC


GGAGCCATCAAGAGCCTCAGAGAGCGGATTCTCCCTTGGAGCAACCAGAGCGCAGCCCCCTGACTCAGGATGACAGACAGGTGGAAC


TGCCAGTGTAGAGGGAATTCTAAGACCCCTCACCATCCTGGACACACTCGTTTGTCAATGTCCCTCTGAAAATGTGACGCCCAGCCC


CGGACACAGTACTCCAGATGTTGTCTGACCAGCTCAGAGAGAGTACAGTGGGACTGTTACCTTCCTTGATATGGACAGTATTCTTCT


ATTTGTGCAGATTAAGATTGCATTAGTTTTTTTCTTAACAACTGCATCATACTGTTGTCATATGTTGAGCCTGTGGTCTATTAAAAC


CCCTAGTTCCATTTCCCATAAACTTCTGTCAAGCCAGACCATCTCTACCCTGTACTTGGACAACTTAACTTTTTTAACCAAAGTGCA


GTTTATGTTCACCTTTGTTAAAGCCACCTTGTTGGTTTCTGCCCATCACCTGAACCTACTGAAGTTGTGTGAAATCCTAATTCTGTC


ATCTCCGTAGCCCTCCCAGTTGTGCCTCCTGCACATTGATGAGTGCCTGCTGTTGTCTTTGCCCATGTTGTTGATGTAGCTGTGACC


CTATTGTTCCTCACCCCTGCCCCCCGCCAACCCCAGCTGGCCCACCTCTTCCCCCTCCCACCCAAGCCCACAGCCAGCCCATCAGGA


AGCCTTCCTGGCTTCTCCACAACCTTCTGACTGCTCTTTTCAGTCATGCCCCTCCTGCTCTTTTCTATTTGGCTAATAGTATATCAA


TTTGCACTTATCTGGACGCACAGAACAGTCTCTCCGTGGGAGGAGACATTATGGGGCGTCCACCACCACCCCTCCCTGGCCATCCTC


CTGGAATGTGGTCTGCCCTCCACCAGAGCTCCTGCCTGCCAGGACTGGACCAGAGCAGCCAGGCTGGGGCCCCTCTGTCTCAACCCG


CAGACCCTTGACTGAATGAGAGAGGCCAGAGGATGCTCCCCATGCTGCCACTATTTATTCTGAGCCCTGGAGGCTCCCATGTGCTTG


AGGAAGGCTGGTGAGCCCGGCTCAGGACCCTCTTCCCTCAGGGGCTGCACCCTCCTCTCACTCCCTTCCATGCCGGAACCCAGGCCA


GGGACCCACCGGCCTGTGGTTTGTGGGAAAGCAGGGTGGACGCTGAGGAGTGAAAGAACCCTGCACCCAGAGGGCCTGCCTGGTGCC


AAGGTATCCCAGCCTGGACAGGCATGGACCTGTCTCCAGAGAGAGGAGCCTGAAGTTCGTGGGGCGGGACAGCGTCGGCCTGATTTC


CCGTAAAGGTGTGCAGCCTGAGAGACGGGAAGAGGAGGCCTCTGGACCTGCTGGTCTGCACTGACAGCCTGAAGGGTCTACACCCTC


GGCTCACCTAAGTGCCCTCTGCTGGTTGCCAGGCGCAGAGGGGAGGCCAGCCCTGCCCTCAGGACCTGCCTGACCTGCCAGTGATGC


CAAGAGGGGGATCAAGCACTGGCCTCTGCCCCTCCTCCTTCCAGCACCTGCCAGAGCTTCTCCAGGAGGCCAAGCAGAGGCTCCCCT


CATGAAGGAAGCCATTGCACTGTGAACACTGTACCTGCCTGCTGAACAGCCTGCCCCCGTCCATCCATGAGCCAGCATCCGTCCGTC


CTCCACTCTCCAGCCTCTCCCCAGCCTCCTGCACTGAGCTGGCCTCACCAGTCGACTGAGGGAGCCCCTCAGCCCTGACCTTCTCCT


GACCTGGCCTTTGACTCCCCGGAGTGGAGTGGGGTGGGAGAACCTCCTGGGCCGCCAGCCAGAGCCGGTCTTTAGGCTGTGTTGTTC


GCCCAGGTTTCTGCATCTTGCACTTTGACATTCCCAAGAGGGAAGGGACTAGTGGGAGAGAGCAAGGGAGGGGAGGGCACAGACAGA


GAGGCTACAGGGCGAGCTCTGACTGAAGATGGGCCTTTGAAATATAGGTATGCACCTGAGGTTGGGGGAGGGTCTGCACTCCCAAAC


CCCAGCGCAGTGTCCTTTCCCTGCTGCCGACAGGAACCTGGGGCTGAGCAGGTTATCCCTGTCAGGAGCCCTGGACTGGGCTGCATC


TCAGCCCCACCTGCATGGTATCCAGCTCCCATCCACTTCTCACCCTTCTTTCCTCCTGACCTTGGTCAGCAGTGATGACCTCCAACT


CTCACCCACCCCCTCTACCATCACCTCTAACCAGGCAAGCCAGGGTGGGAGAGCAATCAGGAGAGCCAGGCCTCAGCTTCCAATGCC


TGGAGGGCCTCCACTTTGTGGCCAGCCTGTGGTGGTGGCTCTGAGGCCTAGGCAACGAGCGACAGGGCTGCCAGTTGCCCCTGGGTT


CCTTTGTGCTGCTGTGTGCCTCCTCTCCTGCCGCCCTTTGTCCTCCGCTAAGAGACCCTGCCCTACCTGGCCGCTGGGCCCCGTGAC


TTTCCCTTCCTGCCCAGGAAAGTGAGGGTCGGCTGGCCCCACCTTCCCTGTCCTGATGCCGACAGCTTAGGGAAGGGCAGTGAACTT


GCATATGGGGCTTAGCCTTCTAGTCACAGCCTCTATATTTGATGCTAGAAAACACATATTTTTAAATGGAAGAAAAATAAAAAGGCA


TTCCCCCTTCATCCCCCTACCTTAAACATATAATATTTTAAAGGTCAAAAAAGCAATCCAACCCACTGCAGAAGCTCTTTTTGAGCA


CTTGGTGGCATCAGAGCAGGAGGAGCCCCAGAGCCACCTCTGGTGTCCCCCCAGGCTACCTGCTCAGGAACCCCTTCTGTTCTCTGA


GAAGTCAAGAGAGGACATTGGCTCACGCACTGTGAGATTTTGTTTTTATACTTGGAAGTGGTGAATTATTTTATATAAAGTCATTTA


AATATCTATTTAAAAGATAGGAAGCTGCTTATATATTTAATAATAAAAGAAGTGCACAAGCTGCCATGTGA





HUMAN PROTEIN SEQUENCE: hP27-014.3 (Seq ID No: 46)


MPPSPLLKGCAEGWPVRLGPGKVKVCLGPLGARAALRIPGQRCGPRPGRPLRSSQRASERARAADAPGRDPAARNTAPGAAGRCPPT


TWLGSLLLLVCLLASRSITEEVSEYCSHMIGSGHLQSLQRLIDSQMETSCQITFEFVDQEQLRDPVCYLKKAFLLVQDIMEDTMRFR


DNTPNAIAIVQLQELSLRLKSCFTKDYEEHDKACVRTFYETPLQLLEKVKNVFNETKNLLDKDWNIFSKNCNNSFAECSSQGHERQS


EGSSSPQLQESVFHLLVPSVILVLLAVGGLLFYRWRRRSHQEPQRADSPLEQPEGSPLTQDDRQVELPV*





HUMAN mRNA SEQUENCE: hR27-014.4 (Seq ID No: 47)


TTGGGACGATCATAGAGCGCTAGCACTGAATCAGCCTGGAGAGCGCGGAAGGAAAGGGTCGGTCCGCAGAGGGCGCGGGGAAGGCAG


GGTGGGACGCGGTGGAGCCCGCGCTCGTTTGCTGAAGGCTTGGAAGTGCAGCGCAGAAGACAGAGGGTGACTAGGAAGACGCGACGA


GCGGGGCTGGCCGGCCGGCGGGTGGGGGAGGGGAGGCGGGGGAAGGCGGCTGAGTGGGCCTCTGGAGTGTGTGTGTCTGTGTCAGTG


TGTGTGTGTGTGTGTGTATGTGTGTGTCTGGCGCCTGGCCAGGGTGATTTCCCATAAACCACATGCCCCCCAGTCCTCTCTTAAAAG


GCTGTGCCGAGGGCTGGCCAGTGAGGCTCGGCCCGGGGAAAGTGAAAGTTTGCCTGGGTCCTCTCGGCGCCAGAGCCGCTCTCCGCA


TCCCAGGACAGCGGTGCGGCCCTCGGCCGGGGCGCCCACTCCGCAGCAGCCAGCGAGCGAGCGAGCGAGCGAGGGCGGCCGACGCGC


CCGGCCGGGACCCAGCTGCCCGTATGACCGCGCCGGGCGCCGCCGGGCGCTGCCCTCCCACGACATGGCTGGGCTCCCTGCTGTTGT


TGGTCTGTCTCCTGGCGAGCAGGAGTATCACCGAGGAGGTGTCGGAGTACTGTAGCCACATGATTGGGAGTGGACACCTGCAGTCTC


TGCAGCGGCTGATTGACAGTCAGATGGAGACCTCGTGCCAAATTACATTTGAGTTTGTAGACCAGGAACAGTTGAAAGATCCAGTGT


GCTACCTTAAGAAGGCATTTCTCCTGGTACAAGACATAATGGAGGACACCATGCGCTTCAGAGATAACACCCCCAATGCCATCGCCA


TTGTGCAGCTGCAGGAACTCTCTTTGAGGCTGAAGAGCTGCTTCACCAAGGATTATGAAGAGCATGACAAGGCCTGCGTCCGAACTT


TCTATGAGACACCTCTCCAGTTGCTGGAGAAGGTCAAGAATGTCTTTAATGAAACAAAGAATCTCCTTGACAAGGACTGGAATATTT


TCAGCAAGAACTGCAACAACAGCTTTGCTGAATGCTCCAGCCAAGATGTGGTGACCAAGCCTGATTGCAACTGCCTGTACCCCAAAG


CCATCCCTAGCAGTGACCCGGCCTCTGTCTCCCCTCATCAGCCCCTCGCCCCCTCCATGGCCCCTGTGGCTGGCTTGACCTGGGAGG


ACTCTGAGGGAACTGAGGGCAGCTCCCTCTTGCCTGGTGAGCAGCCCCTGCACACAGTGGATCCAGGCAGTGCCAAGCAGCGGCCAC


CCAGGAGCACCTGCCAGAGCTTTGAGCCGCCAGAGACCCCAGTTGTCAAGGACAGCACCATCGGTGGCTCACCACAGCCTCGCCCCT


CTGTCGGGGCCTTCAACCCCGGGATGGAGGATATTCTTGACTCTGCAATGGGCACTAATTGGGTCCCAGAAGAAGCCTCTGGAGAGG


CCAGTGAGATTCCCGTACCCCAAGGGACAGAGCTTTCCCCCTCCAGGCCAGGAGGGGGCAGCATGCAGACAGAGCCCGCCAGACCCA


GCAACTTCCTCTCAGCATCTTCTCCACTCCCTGCATCAGCAAAGGGCCAACAGCCGGCAGATGTAACTGGTACCGCCTTGCCCAGGG


TGGGCCCCGTGAGGCCCACTGGCCAGGACTGGAATCACACCCCCCAGAAGACAGACCATCCATCTGCCCTGCTCAGAGACCCCCCGG


AGCCAGGCTCTCCCAGGATCTCATCACTGCGCCCCCAGGGCCTCAGCAACCCCTCCACCCTCTCTGCTCAGCCACAGCTTTCCAGAA


GCCACTCCTCGGGCAGCGTGCTGCCCCTTGGGGAGCTGGAGGGCAGGAGGAGCACCAGGGATCGGAGGAGCCCCGCAGAGCCAGAAG


GAGGACCAGCAAGTGAAGGGGCAGCCAGGCCCCTGCCCCGTTTTAACTCCGTTCCTTTGACTGACACAGGCCATGAGAGGCAGTCCG


AGGGATCCTCCAGCCCGCAGCTCCAGGAGTCTGTCTTCCACCTGCTGGTGCCCAGTGTCATCCTGGTCTTGCTGGCCGTCGGAGGCC


TCTTGTTCTACAGGTGGAGGCGGCGGAGCCATCAAGAGCCTCAGAGAGCGGATTCTCCCTTGGAGCAACCAGAGGGCAGCCCCCTGA


CTCAGGATGACAGACAGGTGGAACTGCCAGTGTAGAGGGAATTCTAAGACCCCTCACCATCCTGGACACACTCGTTTGTCAATGTCC


CTCTGAAAATGTGACGCCCAGCCCCGGACACAGTACTCCAGATGTTGTCTGACCAGCTCAGAGAGAGTACAGTGGGACTGTTACCTT


CCTTGATATGGACAGTATTCTTCTATTTGTGCAGATTAAGATTGCATTAGTTTTTTTCTTAACAACTGCATCATACTGTTGTCATAT


GTTGAGCCTGTGGTCTATTAAAACCCCTAGTTCCATTTCCCATAAACTTCTGTCAAGCCAGACCATCTCTACCCTGTACTTGGACAA


CTTAACTTTTTTAACCAAAGTGCAGTTTATGTTCACCTTTGTTAAAGCCACCTTGTTGGTTTCTGCCCATCACCTGAACCTACTGAA


GTTGTGTGAAATCCTAATTCTGTCATCTCCGTAGCCCTCCCAGTTGTGCCTCCTGCACATTGATGAGTGCCTGCTGTTGTCTTTGCC


CATGTTGTTGATGTAGCTGTGACCCTATTGTTCCTCACCCCTGCCCCCCGCCAACCCCAGCTGGCCCACCTCTTCCCCCTCCCACCC


AAGCCCACAGCCAGCCCATCAGGAAGCCTTCCTGGCTTCTCCACAACCTTCTGACTGCTCTTTTCAGTCATGCCCCTCCTGCTCTTT


TGTATTTGGCTAATAGTATATCAATTTGCACTTATCTGGACGCACAGAACAGTCTCTCCGTGGGAGGAGACATTATGGGGCGTCCAC


CACCACCCCTCCCTGGCCATCCTCCTGGAATGTGGTCTGCCCTCCACCAGAGCTCCTGCCTGCCAGGACTGGACCAGAGCAGCCAGG


CTGGGGCCCCTCTGTCTCAACCCGCAGACCCTTGACTGAATGAGAGAGGCCAGAGGATGCTCCCCATGCTGCCACTATTTATTGTGA


GCCCTGGAGGCTCCCATGTGCTTGAGGAAGGCTGGTGAGCCCGGCTCAGGACCCTCTTCCCTCAGGGGCTGCACCCTCCTCTCACTC


CCTTCCATGCCGGAACCCAGGCCAGGGACCCACCGGCCTGTGGTTTGTGGGAAAGCAGGGTGGACGCTGAGGAGTGAAAGAACCCTG


CACCCAGAGGGCCTGCCTGGTGCCAAGGTATCCCAGCCTGGACAGGCATGGACCTGTCTCCAGAGAGAGGAGCCTGAAGTTCGTGGG


GCGGGACAGCGTCGGCCTGATTTCCCGTAAAGGTGTGCAGCCTGAGAGACGGGAAGAGGAGGCCTCTGGACCTGCTGGTCTGCACTG


ACAGCCTGAAGGGTCTACACCCTCGGCTCACCTAAGTGCCCTGTGCTGGTTGCCAGGCGCAGAGGGGAGGCCAGCCCTGCCCTCAGG


ACCTGCCTGACCTGCCAGTGATGCCAAGAGGGGGATCAAGCACTGGCCTCTGCCCCTCCTCCTTCCAGCACCTGCCAGAGCTTCTCC


AGGAGGCCAAGCAGAGGCTCCCCTCATGAAGGAAGCCATTGCACTGTGAACACTGTACCTGCCTGCTGAACAGCCTGCCCCCGTCCA


TCCATGAGCCAGCATCCGTCCGTCCTCCACTCTCCAGCCTCTCCCCAGCCTCCTGCACTGAGCTGGCCTCACCAGTCGACTGAGGGA


GCCCCTCAGCCCTGACCTTCTCCTGACCTGGCCTTTGACTCCCCGGAGTGGAGTGGGGTGGGAGAACCTCCTGGGCCGCCAGCCAGA


GCCGGTCTTTAGGCTGTGTTGTTCGCCCAGGTTTCTGCATCTTGCACTTTGACATTCCCAAGAGGGAAGGGACTAGTGGGAGAGAGC


AAGGGAGGGGAGGGCACAGACAGAGAGGCTACAGGGCGAGCTCTGACTGAAGATGGGCCTTTGAAATATAGGTATGCACCTGAGGTT


GGGGGAGGGTCTGCACTCCCAAACCCCACCGCAGTGTCCTTTCCCTGCTGCCGACAGGAACCTGGGGCTGAGCAGGTTATCCCTGTC


AGGAGCCCTGGACTGGGCTGCATCTCAGCCCCACCTGCATGGTATCCAGCTCCCATCCACTTCTCACCCTTCTTTCCTCCTGACCTT


GGTCAGCAGTGATGACCTCCAACTCTCACCCACCCCCTCTACCATCACCTCTAACCAGGCAAGCCAGGGTGGGAGAGCAATCAGGAG


AGCCAGGCCTCAGCTTCCAATGCCTGGAGGGCCTCCACTTTGTGGCCAGCCTGTGGTGGTGGCTCTGAGGCCTAGGCAACGAGCGAC


AGGGCTGCCAGTTGCCCCTGGGTTCCTTTGTGCTGCTGTGTGCCTCCTCTCCTGCCGCCCTTTGTCCTCCGCTAAGAGACCCTGCCC


TACCTGGCCGCTGGGCCCCGTGACTTTCCCTTCCTGCCCAGGAAAGTGAGGGTCGGCTGGCCCCACCTTCCCTGTCCTGATGCCGAC


AGCTTAGGGAAGGGCAGTGAACTTGCATATGGGGCTTAGCCTTCTAGTCACAGCCTCTATATTTGATGCTAGAAAACACATATTTTT


AAATGGAAGAAAAATAAAAAGCCATTCCCCCTTCATCCCCCTACCTTAAACATATAATATTTTAAAGGTCAAAAAAGCAATCCAACC


CACTGCAGAAGCTCTTTTTGAGCACTTGGTGGCATCAGAGCAGGAGGAGCCCCAGAGCCACCTCTGGTGTCCCCCCAGGCTACCTGC


TCAGGAACCCCTTCTGTTCTCTGAGAAGTCAAGAGAGGACATTGCCTCACGCACTGTGAGATTTTGTTTTTATACTTGGAAGTGGTG


AATTATTTTATATAAAGTCATTTAAATATCTATTTAAAAGATAGGAAGCTGCTTATATATTTAATAATAAAAGAAGTGCACAAGCTG


CCATGTGA





HUMAN PROTEIN SEQUENCE: hP27-014.4 (Seq ID No: 48)


MPPSPLLKGCAEGWPVRLGPGKVKVCLGPLGARAALRIPGQRCGPRPGRPLRSSQRASERARAADAPGRDPAARMTAPGAAGRCPPT


TWLGSLLLLVCLLASRSITEEVSEYCSHMIGSGHLQSLQRLIDSQMETSCQITFEFVDQEQLKDPVCYLKKAFLLVQDIMEDTMRFR


NNTPNAIAIVQLQELSLRLKSCFTKDYEEHDKACVRTFYETPLQLLEKVKNVFNETKNLLDKDWNIFSKNCNNSFAECSSQDVVTKP


DCNCLYPKAIPSSDPASVSPHQPLAPSMAPVAGLTWEDSEGTEGSSLLPGEQPLHTVDPGSAKQRPPRSTCQSFEPPETPVVKDSTI


GGSPQPRPSVGAFNPGMEDILDSANGTNWVPEEASGEASEIPVPQGTELSPSRPGGGSMQTEPARPSNFLSASSPLPASAKGQQPAD


VTGTALPRVGPVRPTGQDNNHTPQKTDHPSALLRDPPEPGSPRISSLRPQGLSNPSTLSAQPQLSRSHSSGSVLPLGELEGRRSTRD


RRSPAEPEGGPASEGAARPLPRFNSVPLTDTGNERQSEGSSSPQLQESVFHLLVPSVILVLLAVGGLLEYRWRRRSHQEPQRADSPL


EQPEGSPLTQDDRQVELPV*

















TABLE 5










MOUSE GENOMIC SEQUENCE: mD28-002 (Seq ID No: 49)



CGCGGCATGAGCCCCGCGTGCCCCACTGCTCGCCGGGCTGCTCCGAGCCGGGGTGCTCCGGGGCTCCAAACTCGGGCTGGCGGGGCA


AGTGTCTTCATGAACCCAGAGGATGTCCGGGAAGCACTACAAGGGTCCTGAAGTCAGTTGTTGCATCAAATACTTCATTTTTGGCTT


CAATGTCATATTTTGGGTAAGTTGGAGCGCTCCTGGGTTTCCAAGTGCTGTGGCGGATGGGTGGGCGACGGTCCCCCGCCGTGGTCG


CTGCTTTACTTTTCGCCGCCCCCGGAGCTCCTGCCCCAGTCGCGGCGAGAGGCGTCTACCTTCCGCCTTCCCGGCTCGAGCGCGGGG


GAGAGAAACACTTCATCCTTTCCAGGACTCCGAGGAGGTGAAAAGAGGAACCAAGCCGGGCAGGGGGCAGCCAGGCCTCGGGGTGGC


TTTTTTCTTTCTTTTCTTTCTTTCTTTCTTTTTTTTTTAAGGGGGTGGGGGGCGCGAATAGCTGGGGTACAAATGGGAGGACGGCTC


GGCAGTTTGAGAAACGAGGGAGCACACGGATTAGATTTGCTTCCCGTGGGATCTGGATGTTGGGCAGAGCGTGGTGTCATAATGGGG


CAGGCTAATCGGGCAGAGCCGACCCCGAGATCCACCTTCCAGCGCCGATCTGATTGGCCGAGGGCTTGGCTCGGTGTTGCCGCGGCT


GGTCTGTGCCGTGCTCAGCGTGTATCTCCTTGCACCATCTCCGGCTTTGTGTAAGATGCAGATGCCGTGGTGTGTGGCTCTGTAATG


TGCACGTAAATAACACGTCCTGCATGCTCCTCTCCGGCAGTAAAGCGCTCCCTTTGCATAATGGACTGGCCAAGTGGGCGTGCAGGG


TGGAGGGATTTATTTCTCTGTGTATCCTTGTGGAATAACTAGTCATCAGTCAACATATGTTTCGGTGTGCGCGTGCCTCGCGTCTTC


CCCTTTTAAAGGGGTGACACACAGGTTTTCGGAACCCTTGGAGACATGCAAAGGAGAAGGTGTGTAAGACCTGTTTTGCTGGCAGAG


CAGGTGAGCCGCGGCTTGCAAACCGGCTCCCAACCGTGCTCTGCGTGACACTCCCTCGTGCCGGGTGCCTATTGTAATCAGGCTGGG


ACCCTACTCTTTTGTTGTGATTCTTTTCTGAGACCTTCCAAACGTGTTCAGCAACCAGACAAAGAGTTCTCTAGGACAAGAGGGGAA


ATGGTTTGTTGGTTGGTTGGTTGGTTGGCATTGGTTGGCAGACCGTGTTATTTTTCAGCCCACCTATTTCCATCCGGGGTCGCCTTC


CTCCCTGGCACCTCTCTCTCCATGGGAGGGAAAGATGGTGGCGGACCATAGGGATATCCCCAAGTTTCTGCGAGGTAAACAATGATC


CAGTGGTCTGAATCCAGGACATTTTAATTTGGACTCCCCTTAATTGTGGCTGTTTGCTGTAGACATAAACATCTGTGAGAATAGTTG


TAGTTATGCTGATCTTCTGCCCACCCCCTCACTTACCAGCTTATTTTATTTTCTCTCAGAGTAGCTATGTGTGTTTTGTGAAAGGAA


AGGAAATGGACTTTGTGTCAGCATGTCATCTGTCCTCAGGACTGGACCAGATTGATGAGGGAGTGTGGGAACAAATACCATATACAG


CCATTCACGAGTAGTTTTGTTTTTTTCTGTCAGTGATAATATATGGTTTCTGGGAGCAACTCCCCACCCCTGCCCCCCTGCTGCAAA


CAGAGCAAGAGGAAATGCGTTTCTTTCTTTCCTTCTTTTTTTTTTTTTTTTTTTTGCTTCTCTCCTGGACCCTTTCTGGAAATGTTT


AAAAGTGGTGGCTAGGCATGCTTCCCATTGAAGTATTCTGATTGCCTTGAACTATGAGAGGCAAGAGAGGCAAGGGCCGTCACATGG


GGCTGCAGGGGTGGTTCGCCCGGGCCTCTTCTTTCTGCTCCAACACTTCCAAAAGTTGCACATTTCAGCTACCAGGCAACAAAAAGC


ACCCACGGGCTTTCTCTGCAGTTTCAGAGCGGGGAGTGAGAGGGAAATAAAAAGGAATGCGGAAATGTTTCCCTGGCAGTTTGGTGT


AATTTTGTAGCGAGCACAAAGGCAAATTTAGCCCTGTGTCTGGATTAGGCTGCAGCAAACCCCCTGGACTGTGGAGAGCTTCAACAA


AATTGCAGATTGCCTGCATGGAGAGTTTCAGAATAGGACCCACATCTTGTCTGATTTTTGAAGTATTACTGTGGGCGGGCAGTAGGT


AGGCTTGTGGCAAGTCAGAGAACGGTCTGAGGCCCTGAAACTGAAGGAGCTGCCCTGGGCAGCATTGTTAAGTAGGTGTCTACTTCA


GAGAGTCATTTGCTCTCCCTGTCCTTCCAGTGCAGAGGGCCACCTCTAGTTCGTTTTCTATACTGCTCCTGTCTCCAAATGACCTCA


TATTTAAATGTCCTATTTTATCAGGGCCAGTGGGCTCTAGCAGAAATTAGCAGGAAAACATCCACGTTATCATTAAAAGGAATACAC


ACCAAAATATTAGTGACCGGAGATCTGGCAGCAGCTGCCAAAAACATGCACACTTCTGTCTTCGGCCACCAACCTGCCCGTGACTGT


CCAAGATAGCAGAGTCAACACTTCAGTTCAGTTGTACGGTTCTGACGGAGGAATTGGTAACAGAGACCATGGGCTCCCGGTCTTTCA


TCTTCACATTGACGTGCAGAACTAAATTCGAAATTCATTGAAGACATTTGAACGTAATAGTTCTTGTAAAATAAGAGGGAGCGCACA


GTGGCAGCTGTGACAGCTCGGATCTCTTGCTAATCAGCACTCTGTCTGTGTTAGTCAGTTATCTGCCCTGGGCCTTCGTTACTCAGC


TATTCGAATGAAGAATTTGGTTGAATTGTGAGGTTTTTCTCTGTCTCTAACAAAGACTTTGTTGAGTTCTAGTACGCCAGCCAGGCA


AGATCGAGTCTCAGGGATGAGCAGTAGGCTCTAATGATGGACTGGAGACTTGCCTATAGTTATAGATGGTCCTTTAGTAGACATGCT


CACGGACTAATTTGTTTTTCATTCTCTCCTCAATGATCTTTTTTCACTTAAGAAGAAACAAAACAACAAACCTTTCAAACTGAATTT


TCCTTGCTTGTTGAGTTATTGGTATGGCACGCATATTTCCCTATCTCTCCCCTGAATCTCATGTGTGACGCTCTGAGTCATTAGCTG


TATTTTTATTATTAGAATCACAGCTTCATGTGGAGGATCCTAATTCTTTTATATAACAGCAGTGCTGATATTGTGAGTAAGAAAGTC


AACATCTTGTACAGATTCCTTTCTTGTGAGTTAGCACAGGGCGGTGGGGGGGAAAGCCTTGTTTTTCTTGCTCTATATTGGAAGAAC


TCAAGCCAGCAGGAATTGATTTTATTGAGGGTGTCACCAGAGGAAGACATGTATCAGAAACACTGAGTTGTCTTTGGGGCGGAGGAG


AGAAGAGAAGAAGGTTTGTTTTAAGGTCAGTCCTTTGGGGAGTTAATTTCTCTGTCCTGTCACTGACCGTTTATAGATGTTTTGTTC


TGGTTCTTGACACTTAACTGTTTCTCAGAAAGTGAACGTCAACATCCTGGCTACTTATTGCTGCACAGCAAGCTCCCAAACTTTAGA


ATTTCAAAACGAAACCTCATCATGATAGTTCATAATTCTGTGATTTGACTCCTCGGGGGGCTACTTCTAATGTGGGACCTCCGTGCA


GTTGCTGGGAGTTTCTTGCTGTCTCCTTTGGGTGGGGGAACCCCGGGCTGGTGGTCACCTGTGATTGGTGATGCTTACCCATGGCTC


AGTGTCGCTGTCAGCTGTGGCACAGCAGGTGGATTTTTCTGAGGTTCGAAGCAGCTTCCAAGCAGTTTAACTGTACTGTCACTTGGC


ACATTTAGTCTAAGTCCTCATGGAGTCTGCTCAATTGAAGGTTCCATCTTTGGATAGGGAAGTGTCAGGGTCACTTTGTAGAAGGTT


ATGTGGTGGGCTGGCTAGTTTTATATCCACTTGACACAAGCTACAGTTATCTTAAAGGAGAGCATCTCAACTGAAGAAATGCCCCCA


TAAGGGCCGGCTGGAGGGCATTTTCTTAATTAGTGATTGATATGGGAGGGACCAGCCCCACTGTGGGTGGTGCTGTTCTTGGGCTAG


TGGTCCTGGGTGCTATACGAATCAGGTTGAGCAAGCCATGATGAGCAAGCCATGATGAGCAAGTCATAGTTTCTGTATCAGCTCCCG


CCTCCAGGTTCCTGCCCTGCTTGAGTTCCTGTCTTCACTGCTTTGATGAACGGTTTATGTAACTGCAAGATAAGTAAATTCTTCTCT


TCTACCCCTGGTTGCTTTTGGTCATGGTGTTTTATCACAGCAATAGTAACCCTAAGGCATGCGGATTTCAGCCGTCATTGGAAAATG


ATTTCTTAGAAACCATTGATGCGCTGGTCAGCAGAAGCCTCGAGTTGGATGGTGGGACCACTTGATATTTTGTTCTCTGTGCTGTCC


CAGGACTAGAACAGCTGTTGGCTGAAGCCAGATGTCTCTTTGGTGTGTTTTCAGATATTGCTTTGTGTTGCAGGTTGGAGGTTTATC


CAGAGTAAATGGCGGAATGTTGTATATGCTTTGTTCCCACAGGCCAAGAGGAGGGAGATTCAAGGAATCTTGGGTGGTGGGGTGGGG


CGCCAAGTAGGATGTCTTATCTTATGATTCAGTATAAATTTCTAGATGTTCTGGAATGATGGTACATGAGCCGTTTATAAGTCATAA


TTTTTGTTTTAATTTGCTAGACATCTGTTAGCTTCGATGGCAACCATATGGGAGTCTAAATTGCCTTTTGAATTTCAGGGAGAGGGT


TGGAAGAAAGCTAAATGTGGCTATGGAAGTGTCAGGTAGGGAATGTGTGCAGACCTCAGAGGGGAGAGTCACGATGCACCCAGTGTC


TTGCCTCTTCCAGCAGTTCACTGTGGGGCTGATGCGTTCTCAATGGACGATGCTCTTGAAGGTTGAAATGGAGCCACTAGCAAAAGT


CGGAAAACCAGATAACATTCCGCCCTGCATAGAAGTTATGAAAAGGGTGAAATAAACACTTCTGCAGTGGGACTTGGAGTAATCTGA


GGGACATTTTATATGCTTTTAAAAATCAGAATTTAATTGGGATGCCAGATTTCTAGCAACTTGCATCTTTAGTTTCCCAAATAATCT


GGAAGTTAGCATTTGATAATGATTTTTTTAGAAAAAAAAAAAAAAAAAAAGAAGTTGCATTTGGGAGCTCATTTAGTTGGATCTCTC


TGTCCCAACATTCAGATTGGCATGCCTTTCCATACAACAGGGGAAAGCAATGTGTTCTTTTGATTTCTACATGGGGCCTTGCTCTTT


AACCCAGTGTGGTCTCTAATTTTGGCTCCTGTGCTACTCCTCCATCTCTCACTAGCGGCTGAGGCTTTTTAGCTATAATCTGCTGTG


CCTAGAACCGTGTGTGTTTTCAAAAACCCCACAGCTTTACCATTGTGATGTCCTTTTTAAAAGCCTGTAAAAGTATCTGACAAAGAC


CTATGGTGATATTTTTGTGACCAGTAAAAGAAATTGGAGCACAGAGATGTGAAATGGCTCTCGTGGTGTTGGAGCGCTTGCAGGTTC


GCTTGGGGAGTGTTAAGTCGACGCTGTAGCTAGAGCCCCAGTTTCTCAGACTGAAACTTATTTTAGAAGATGCTTGTTATTCTAAAA


TTAAACATCAAGTAAGTCATTTGCATCTGTTCATAATTGAAAAGTGATAAAGTTTTTGCATATGCCACAATTAACACCACCCACAAG


CACCCACAAAAAAAGTTTAGGATGAAATGTTCTTAAAGAGAATGCTAGGATATAATAAATTATTATGTAGTCTGTTGAAAAATTCAT


AAATGACAATTAGAGTATTAATGAGGGTATTTTTTTTTTGAGTCACATGTTTATTTCTACGCGTAATACCAACTGCCTTAAGGTGAC


TAACCTCAGGATTCTAACTTACTGTTCAGTACGGGATGATAAGGGCCTCCTGTTTGTGAACAACCATCTCCCAATCGTTTCCTTAAG


CCTCGTGTGTCATGTGTTGTCTGGAACACATAGGCATCTAATAACTGCTTGTTGAATGGATGAGCTTCCGAATGTTGAGAAAGCCCA


TGGGGTTTATCCTTCAAGCCAAGGAAGCCTTGTCTTTCACAACAGGCAGTTAGCATCTAAGGGGTGTTTGTCTTTGGAACATTTAGT


TAGAGAGCTGCGTCTGTCTTCAAACCAGATGTAAGGTCTCTCTGAAAATTTCAGCCTCCTAGTTTACTGTTGATTTTTCTTTTTTAA


TTAAAAATATTTTAAAAATATTATGTATATGGGTGCTTTGCCTGCACATATGTCTGTGCACCACATGCATTCCTGGTTCTTGCAGAA


GCCAGAGGAGGATGTTGGATCCCCTGGAACTAGAGTTACAGATGGTTGTGGGCCACTGTGTGGTTGCCAGTGCCCTGAAACACAGAG


CCACCTCTCCAGCCCTCCTGGTGCTGACTTCTCACTTGAATTTCTTTTCTTTTCTTTCTTTTTTTATTTTTGGTTTTTCGAGATGGA


GTTTCTCTGTGTAGCCTTGGCTGTCCAGGAACTCACTCTGTAGACCAGACTGGCCTCCAACTCAGAAATCCACCTGCCTCTGCCTCC


CAAGTGCTGGGATTAAAGGCATTCACCACCACTGCCCAGCCTCACTTGAATTTTAACATATATCTCAAACCTACAGGAAATGTTAGA


GGAAACAAATGATAAAGTTTGCTACTTCAGACATGTTATTCATATATCTTTAAGTTTTCCAACTTGTTTTTATCATGGTTAAGGACA


AAGTTGTCTGCCTGATGGCTCTCACAAACACAGTGTGGATTTCGTCTCGAAGGGTTCTCTCCTTGATAGCCACAGTGCCACCATCAA


AGCTAGCAAATTACTCCCATCCACTTCCCAGGCCTTGGGTCTCCTTCACTCTCCCAATCTCAATAATTCCATTTAAAGCAAAGGAAT


TCAGGCCAGAACGGCACAATATGTGGGGTTCTGTTAAGGCTCGTCCAGTCCCTCACTATCAAGAGCGTGTGACTGGCATTGCTGGCT


GCCCTCCCTGTGGGTTGCCTGTGGGCTCCTCAGGCGCAGGTTCTGGCTGTGTGTTCTGGGGTGGCAGCGGCCAGAAGGGACGCTTTG


CTTTCATCCGAATCCCATACGTGGCAGTGGTTGTTGCTTTAGGCGTTTTCTCTGCCAAGTGTCTCCGATCATGTTACTAACTTTTGT


TGCTTTGGCAACTTGTAACTGCTTTTTGGCAAGCCACTTCGAAGCTATAGAACTGCCCATCTCTCCTGGACTTCCTATCAGTAATGA


ATGTCTGTCAGCAGCGTTTCATGGCTTCTCCTTTTCCATCTTGGTATGTTTCAACAACGAATCCAAATTAACCCCTTTTCTCTTAAA


GTTGCTTCTGTAAGGCATTGGGTCACAGTGATAAGAAAAGTAAGCAAACCCTTTGCTCTCTTTAAAAAGTTAATTTATTAATTACAT


CCTAATTGCTGCCCCCCAGAGCTCCCCTTCACAGGGTCCCTTCTCCCCTCCTCCTCTGAGAGGGTGGGGCCCCCCCTGGATATCCCC


CCTTCCCGACCCTGGTACATCAAGTCTCTGCGGTGTTAGGCACATCCTCTCCCACTGAGGGCAAACAAGGCAACCCTGTTAGGGAAT


GGTCTCCACAGCCAGGCAACAGCTTTAGGGATAGCCCCTGCTCTAGTTATTGGGGGATCCTCATGAAGACTGAGCTGCACATCTGCT


ACATATGTACTGGGGGCCCTGGTCTAGCCCATGTATGCTCTTTGGTTGTGGCTCAGTCTCTGAGAGCTCCTAAGGATCCAGGTTAGT


TGACTCTGTTGGTCTTCCTGTGGAGTTCCTATCCCCTTCAGGGCCTTCAATCCTTCCCCCAACTCTTCCACAAGAGTCACCAGTGGA


CAACTTTGTTTAGCTGTGGATATCTGTATCTGTTTCAGTCAGAGGACAGTTATGCTAGGTTCCTGTCTGCAAACATAACAGAGTATC


ATTAATAGTGTAGGAATTGGTGTTTACCAATGGAATGAGCCTCAAGTCGGGTCAGTTAATGGTTGGCCATTCCTTCAAGTCTCTGCT


CCGTCTTTGTCCCTGAATTTCTTTTAGACAGGACAAATTTTGGGCCGACATTTGTGGGTTGGGTTGGTGTCTTTACCCCTCCTCTGG


TGGTCCTGTCTGACTACAGGAGGTGGCCTCTTCAGGTTCCATATCCCCGCTGTTATGTGTCTCTTGGCTAAGGTCATCCAGATTGAC


TCCTGGGAGCCTCCCCCATCCCAGATCTGTGGGACTTCCTAGAAATTTTCCCCAGCCCCCAACCCCAGCAGCTGCAGATTTACATTT


ATTTACATTTATTCTCCTGGCCCTCAGGCCCTCTCTCCTGTCTCTCCCAACACCTGATCCTGCCCCTCAACCCTTTTCTCTTACCTG


CCAGTGCACTGGCATCCTGGACCACAGCCCTTCATCCTTATGGGACATCCCTCTTTCTATGGTATGAGTTCTAGGCTCTTGCAGCAT


CCTTCTGCTGCCCTGCTTGGTCCTCTCCAGACACTCATATTCCTCCCCCATGGTCCTTCCTTATTTAAAAATAGCCTTGATGCCATT


TCTCAAACCATTTCTCATCTCTGGAGGATCCCACACCCTCCTTGTGTCTCATGGATAGGCTGTGCTCTGGCCTGATCATAGCCTCTG


GTCATAGTGTTCTGCCCAAGGTCTTATTTGCATGCACTTTCCTTAATGTAGGCACCAGAATGGGACACGTTTTCCATAAGTTCTTCA


GTCCCTCTAGAGGGCTGTTACCTTTGAGCTCTCCCCTTCTACACAGAGCTGCATCTTGAGCCAGGCTGTGCTGGTCTGGCCTGGAAG


AAATTACTATCACATTAGAGAGTGATGTTTAGTTACTCATCAGAAAGGCTGGGCAACACATTTCCAGAGTCGTCTTCCTGTATTAAA


TGAGATTATACATGTGAAAGCACTTGGTAAGAGGCAAATCTCCCTGTGTAAACATTAGTTATTAACCCAGGCTAAGCTGTACTCATA


TCCCAACAGCCAGGGAATGTCGCTGGCTCAGGTTGAATTTCTGGCGAGTTTAACCTTCCGTCTTCTTTCAAATGAACTTTGGCTAAG


TCTATCCATCCAGGGTGGACACTAATCTCTGAAGCCTTAACTTTTACCCTACAGGTTTCAGTTTGGACCTGTCATTGCATAGATCTC


CTGCTTACGTGGGTATTTCTGGCCCATTGCTTTTCAAACTTAGCTGCACCCANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGGGAGAGAGGGGAGGAAGGAGGGGGGAGAAGAAGTAGAAGAAGAAGAAGAGGAG


GAGGAGGAGGAGGGAGAAGAGGAGGAGGAGAAAGCATTATAACCTTTAGAAGTCCATGGGACTCATCTTTCCAGCCATGGAAGCCTA


AATGTCTAAGGTATGTTTTGAAAGCTTGCTGCTGGTGCTGAGGCTGTAGCGCACTGATGCCATTCTTGCTCAGTATGCACAGAGTCC


TGGCTTGTATCCCCTTCAGTGACAAAAATCAAAATGATCGGCAGGTGGTAGATGGTTAGATGACAGGGAGTTAGCAAGTACGTACAT


AAATTAAGCAGCAGTGCTCAGATGGGCTTTCCTCTTGTAGTCTTCACCATGGGTGAGGAGACTTCTGGAGGATATGATGATTGGCAA


TTTTACCTCCCTTTGGACAGCAGCAAGCTAGAAAGCCTCAAACTTTTCATTGAGGTGTGTGTGTCTGGGGGGCATCTGGTTCAGTAG


GTCCAGACAGGGTATAATTTGGTGGAATGAGTGTTATATTAAAAAAAAAAAAGTCTTACAGCTGACTCGAAAACCCAGGCTGTGGTT


TATTTTTTCAGGGTGGGAGAGATGTGTCTTGACCCTTCCTTCCGTTTTTGAGGGAGGCAGATGGGCGGTGTGCAAATACTTGTGAAG


GGTGATTGATTGCACCAGCACCGGAAGCTGCTGCTATTCACTTACGGGGATAAAAAAAATGAAAAATGTAGCCCAGTTAATCCCGCA


AGGAATTTCTTATTAATCCAAAAGTGCCAGGTTATTTTTAAACCCGTGGGCCTTAAAAACAAAATGAGAGCATGTCTTTAAAGAGAG


CGTGTGCCATAGTGGGTATGCCAACAGGCAGGGCCGGAGAGGGAAGGAAGCCAGTTAGAGCAGGCAGGGTGGGAAGCTCTGCACCCG


CCTGTGGGATCTGCCTGTGTCACCGCAGATGGAGAGCTGATTACCACACACGGCCTCCCTCTGGAGCACCCACAGTGCTTCCTGACA


ACTGTCCTATCCTGGGCTGCCCAGACCTCTGACCCTGGGCACTCTCTTCAGAGGGAGGCCTTGACAGAGGTGACTGCTGCAGAGCAG


GGAAGGAACATTCCTTCTCCCAGATCCAGGTCATCAATGTAGCTGCCAGGACAGGTAACAGCAAAGCAAACGTGGGAGACAAATAGG


ATGTCTCAGTTTTCTTTGCAAAGAAGTTTCAGTGTATAATATCCAAAGCTTTCTGCATAGAGCAGGCTCCCTCCCTCTTTCCTTTCC


TTTCCTTTCCTTTCCTTTCCTTTCCTTTCCTTTCCTTTCCTTTCCTTTCCTTTCCTTTCCTTTCCTTTCCTTTCCTCTTTCTTTGCC


ATTCTTCTACCTCCTAGTCTCTCTCTTCCTTCCCCCAGCCCCTTAAAAATTACATATTTTGATTATAGCCAGGTACCCAAAGTGGAG


ATATTTTGAAAAAGTTGAAATTTTGAATAAAAATATCCATTATCGGAGACATTTCACTGGGGCTAGACCATCTATCTCCTAGAATGG


AAAACAAAACGAAAAGAAATAAAAAGCTTAAAACCAGAGTGGCATACAAAAGCAATGTTATCCCTGTGGTACTATCCGTATGTGTGT


AGAGGATTGCTAATTATGAATTGTAAGGTGTAATTTAAAAATGTATAATCACCAACCTTATTAGCAGAGTAGTTTCAGGAGTGCGTG


GTAGGACAGTTTGCCACCTCGCTGCAGGCTTGGCGATGCTCTGCCCGCTTCCAGCAAGTGTTTACTGTCTACATGTAGATTGCATGA


CATAGGCTCATCTACTTGCCCAACGTTCTTTCTAAATTACTCTTGGCACCAAGGCTTGAATTTCTAAAAATCTGGAGGGAACAGCTG


GTGCTCTAATAAATATTCAGGCCAGCTATTTTAATGCTTTGTACTCAATTAAGTAGTCCTAATAAAAGAGGAGCCCTTGCCCTAAGC


ATTTCTCAAAGAATAATGTTTTGCTTCTAACAAAAAACTTTCTCCCAGTGTTAGTTAATATTTCTCCCAGGCAACTTTAAAACTTCG


TTGCATCCAGTAGGTCTTTTGCCCATTCGTGACGAGGCTCAGTCCTGAAGTCTGCACTTCCTTGGCCCATATCTTTTAACTGACGAC


GACCATAGGCCACTCATTCACTTTCTAGGGAAATTCTCGGGCTTTGTTTTTTGAGATGGTCTGTTCAAGACTGTCCTTCTGACTGGC


CTTGAACTCATGACTCTTCAGCCTTAGCATCGCAAGTGCTGAGATCGCTGACATGTGCTACCACATCCAGGGTTTACCTGACATAGC


TTTACACAGTAACCCATCGTGCAGCTTGGCTTAGGCCTCTGGTGCTCTTGGGTGATATGGAGTCTGCTGTTAAGCATTTGGGCTTCA


AGAGTGCGGCAAGTTTTCTTCTACACCATTCTAGCCTTGGGACCTTAGGCAAATTATTTAGTTGCTGGTGAAGTCTTCTTTTGCAAA


ATGGTACGTTTAGTAGTAGTTTTAATATTATTATTTTGTTAGGACCTGCATTTGAATGCAGTATTTTACAAGTACCAAACAAGCAAA


CAAGCAAGCAATAGTCTTACCATCAAGATACATCCCCAGCAATTTATATTCTCCTTCACCTCTATTTTGAGACACAGTTTTACTGTG


TATCTCTGTGTATTTTGAAACTTACTATGTAGACCATACTGGGCTCGAACAGTCAGAAATCTGCCTGCCTCTGCCTCCTGTGTGCTG


GGATTAAAGACGTGGAGCACCACTGGTTAATTACTATTCTGTTTTTCTTTTTAAAGATTTATTTTATGTATATGAGTCCACTGTAGG


TGTGTTCAGACACACCAGAAGAGGGCATCGGATCCCATTAGAGATGGTTGTGAGCCACCATGTGGTTGCTGGGAATTGAACTCAGGA


CCTCTGGAAGAGCTGTCAGTGTTCTTAACTACTGAGCCATCTCTCCAGCCCTAATTAATATTCTTAACGGGACTATTAAAACCTAGA


ATAATCTATCTCAGTTGTGAGGATGAGAGGAAAGATGTGTAAGCTGCCTGAATGTCCCATCTGTATTGGCAGTTACTACTGGTTTCT


CTACCCCATCATGTCTTTCGTTAGCTTTCCATCCCTTCTTCAGGACCGTTAAGATAATGGTACCATGTAACATACACTTTCTGCTCT


CTGCGCAAGTGTATTCTCAGAATAACTGAAGAAAAGTAGATCCAGCAACTGTTCTCAGTGCTCTTCAGACTGTCCTGGATAGAACAG


AATTCCTATCATGAAGACCAGGCCATGAATTCATAGCTATTGTTTATTTATTGTTATTCTCTTACTTCCAGTACCCAGTGATTTGTT


CAGTGCCGTGACCAAATACCGGTGAGAGACAGTGAAAGGGAGAGAGAGATTACTTTTGCTCACCTTTCAGAGGTATAGCCTGTCATG


CTGGGGAAGGGATGCCGTGTTTGTGGCTGGGTGGTTGTATGGTTAGAGCTCCTCACATTTTGATAGGCCAAGATGTGGAGAAAGTGG


AATGCCGGCTCTTGTGTTTTCTAGGTGGTCAAGTCAACTTGACAATGAGACGAACCATCACAGCTGGTTAGAGTGAATCTTTTTTTT


TTTTTTTTTTTTTTTTTTTGCAAAACCATACTGCCCCATATTAGAATTTTGTACCAGGAAGTCAGGTTTCAGAAGCTCAGCTCTGCT


ACTAAGCCTGACATTTAGTATCAGGGTGTAGGATGGGGATTGAAAGTACTTTATTAGCGTCTCCTAAATGTGGGGATTCTAAAGCTC


TCTAGGTGGCCTGACTATAGTTCTAGCTTTTTATTGTAATGTAAACACTACATATCAGTGCCATGTTTTATCACACACACACATACA


CATACACACACACACACACACACACACACACACACACACACACACTGCATTCTTCACGTCATGAGAATGAACACCCTGCCAGAGATA


GCAATGACTTGTGAGTTAACCCTCATGTGCCCTTTCAAGTGACGCCCAGTTAGGCTTTGGCCTGTACCACCCACATCACCGAAGGAT


TGGGCCACTCATCTCTGTGAATGAGTGATGGACTGACTGGCTTCTCTGGTACTTAAATGAGATGTGCTGTGCACTTGTATCTCAATA


TGGCTGGCTGACATGGAAGGCACTGGCTGCCATAGCTCACCAGCTCACCACGGTCTCCCTTAACCCTGGCAGAAAAGGCATCACAGT


TCATGCAAGGCTGGAGGCATAAAGAACCTTGCTCCTGGGTTGCCATGTAGAAGGTGTGCCGAAGACCCTGTACTTTGTCCTCTGGAA


CCCTATCATCTCTAGGAATCTTACTCCCTATGATTCCAAGTGCAACCTCCAAGGGCCAATCATTGTAAGAGTAGCATGGCCTTGGAC


AAACTTGTGTCTTCACAGAGTCTTTCAGGTGCCTGCATGGTGTATGAGACTCCCGTAACCCATACTTGGGTTTGGTAGTCAAGAAAG


GGGCCTGTGATGTGGCATGTACCTTGAGCAATCTCCCCCTTGATGCTTCCTGTTTGATAATGACATTTTGAGTCACAAGGATCCGCC


CATTTCAAGTTTTTTTTTCTTTTAAGTCAATTCTGTGCTTAAACATTAAAATATACTATTTAAGAAGGGGAAATTAAAAAAAATATC


TCTACTCAGAGGCACACAATGACAAAAACATGGCCTATTCACTTGTAGGTAGCTGTTGGGAACTGCTGGCAGGCCGAGGCCCAGGCT


TGCTTCCTTTGTTATAGAAGTTAACAGGTGTAAAAAGAGTATTTGGCAGTTTGGCACCAGTTGAAGAATATCTCCTTTACCAGAGCA


AAGAATGAATAAAACGGAGAGGAAAGAGCATCCCCACTCAAGGTAATTTATGGCCATGGTTTGAAGTTGTCTCCTCTGGAACCCCAC


ATCTCTCAGAATCTTCCTTTGGGAAATTCCATGTTTAAGCAGTTTGCAAGGCCATATGTGTTTATGAGTTGAAAGTCACAGTTTCTG


GAGGTGCCCTGTTTGTAGAATGTGTTAACATGTTTGTCTTTCGCGTATTCTGTTTCTTTAGAGTGCTGGGCTTGGGAAGCAGAAGTC


TCCTCGACTTCTGAAAACTTGTGAACCCTTGGTCACTGAGTAGTTAGAGTTGAGGTACAAAGGGAAAATAATTTGGGGGTGTATCTC


AGACTCACAGGAAGTCAACCTTAAATGTTTCTGCAGTCTGTCTTAGGAGGCTCCACCTTCTCCTGTTTACTTTATGGTTGAGTTCAA


CATGGCTTAAATCTTGTTATTTGATGCACTTTTAAGGAACAGGATAATTATTGTGTGCTTTTCTATTGGGAAAGCAATATAAAAACA


TGGATAGAATTTTGAAGTAAGGATGCTCATAATCCTAGTAATACTTTCATTGGGTTCAACTGGAACTGGAAGCTTCTATCCAAATGC


TGAAAGCAGCAAACAACTGCACAAAACCAACCAACTACCCAGCCATCCAGCCAACCCACCATCCATCCACCCATCCAGACAACTATG


AACCATCCATCTATCCATCCATCCATCCATCCATCCATCCATCCATCCATCCAGACAACTATGAACCATCCATCTATCCATCCATCC


ATCCATCCATCCACCCATCCATCCACCCATCCATCCAGACAACTATGAACCATCCATCCATCCATCCATCCAGACAACTATGAACCA


TCCATCCATCCAACCCACCATCTATCCATCCATCCAGACAATTATGATCCACCATCCATCCATCCATCCATCCATCCATCCATCCAT


CTATCCATCCAGCGAGCCAGCTAGCCAGCCAGTCATCTTAGAGTTTCTCTCTAGTCATCCGTGAGGCTATGACTTTAGCCTCACTTT


GAAGTGGATACTGCTACATCACTACCCTTTAAGCGTTTGTTTTGCCTTTACTAGCGTCTTCCCCCTCAGGACAACATTGAGAATAAG


TGTTTTCAGCATACAGAGCAATGCCTTGTGAATAAACACTGGTTTCAGTCAACCAGAAAGAGGGAAAGAAAGGAAAATCAATAAACC


TCCTGCAGGCATTTGAGAAACTGTGTACTTTTAAGAGAAGGAATGGCCAGTGATAAGGAGCTTTGCAAAACAATAGCTCTCATCTCT


TCCTTTTTTGAGCCGCTGACTATGACTTTCTGTGCTGAACCTTGTAGCTGGGATTTCCTAGTTCTCTGTTGCCTTGGTTGTGCCCCA


CTTAGCTGGGGAATGACAGCCACTGTCCCTGTGACACCTCAAGGGGAGCAGCTCTACAGCCTTCCTAGATTTTGAATGTCATAGCAG


GAATCCTAAGGAGACCAGTGCTCCTTTGGTTCTGGCTCCTTTTGCTTTGCCTGCTGGTCTTGAGAATCAAGAGTGAAGAGCTGCCTG


GGTGTATATGGCATCTTCATTTTTCCTTAGGTCTGCAAAATTTAACCATTCTTGGTATTCTCGCTGCATGCTTAGAGTGTTCTTCAA


TTGCTATCTGGTGAGAGTTTGAAACAGCTGTATAAGAGTTTGAAATAGTGTTTTACTTCTATTTTTCCTTAAGATGAAGAATCAACA


TTGTAGAAATGAGTGGAAGGCACCAAAGCGACCTGGAAATATCTCTTACACTTTTGTAAAATATATGATTATTTAGTTTAAATACAG


ACATGTGTCACTGATGGCTGTTAAATAGCAATTTCAATATTTGGATTGTCTTAAATATAGATATGTGCTGTCTTTTCGTAGATATGT


ACAGTAATGATCTGAATGACTGATATGTGACCTTTAAATATTTTTATCCATGTTAAGAGAATAAAATGTCTTTATCATAGCATACTA


TAACATTTCAAACTATATGGGACGTTTTGTTTATTTTTTTGAGACAAGTTAGCTCAGGCTGGTCTCTTAACTCATGGCAGTCTTTGT


GTCACAGCCTTCCCAGTGACGGAATTATAGGCATGAGCTACCAGACTTGATGAAATGAAATCTTTTGAAGTTCAACATAAGGCTAGA


GATCAGCTTCGATATTTACAGTGCACACAGGAAGAACCCTGTTGTGTTTCTCATTTGTAGATGGGTCAGAAAGTATATGTATGATAT


GTATAATCATCTCACCCTGAACTGTGGGAGATTGTTGCGTCACAGCTGGGGATAACAGCCCATTCTTTATTGCACCTTTCAAAACAC


AGTTTTAATTTTGAAGTTCCTTCCCATGGAATTTTCCTTCTCTTGCCCCGTTCTTTCTTTGACTTTAACTCCAGGATCGAGGAGGCA


GGGAATCTTCTTAAGGGAGGCTAAACCCCTCTTAGTCTTCAAAATAAAAAGGCTAGCCTGCTGCAGACAGAATAGAGGATTGGGATT


CTTTTGAACAGAAATGGCTGTGCAAATATTTAATCCGTTGTTCTTTAGTTGGTCTATTTAGGGCAGAGTACTGGAAGGAACCGTGCT


TTAATTGGCCTTCTGCAGACCTGATTATGTAACCTTAAGACTTGCATGTTGAAAAGGACGTGAAAAATCCTCTAGTCTCTGTTACCT


ACCAGTCATCTTTCTGCAATCTCCTCTTAAGCATGGATTTTATTCTCCGGCTGTAAGTTATAAAACAGGGGACAGAGCTCTTTTTTT


CTGGCAGCTTTTCATTTTATAGGTCTGAGATGCCCTCAGCCTTACTTGTAGGGGCAGTGTGCAGAGAGGACAGTCAGAGTCCCTGTG


GGTTCGCTCACGGGTCAGGTTTTAGCCTGGCCAGTGGTGAGGATGTCTGTATACCATTTACACACTGATCTGGGGTGAAGGTGGCAT


TTGGCAGTGCTATTGGTAGGATGCCTGAGCGCCGAATCACCCGAGCTGCCAAGTCCCCGTTCTCTCACTCCATTTGGCTCGACTTGA


CAGTTTTGGCTCAGTCATTTTGATTAACATCAACCTTGCTTATGTTAAGTAACTATTCAGGTTATTTATTATGTATTACTCTCATGC


TTTGGAATGAGCGGCCAAGAAACTTCTGCCTCATATGGACTCCATATGCAGCTGTTAAGTTAGCAGAAACACAATTAGTTGGCGCCT


AAGCTGCATATTGAGTAGATTAGGCCGGATCGCACAGGCGTTGTTTGAGATTGTTGTCTCCAATATTTAAGAAAGCTATTAGGTGTT


TGAGGATGTGGGGTGATAAAGCATCTCTGAGTTCACATATGTCCTGTTTTGTATTTTTATTATGGAGTGCAAATATCTGTGGAATCT


TGGTTGTTTGTTTTGCACTGCTGAGCTCCAGAGAGGATTAAAAACATAGTCTGTGAAAAACAGACATCTCTTTATTTCCATTGTTCC


CTCCCCATCCCAGGCTAGGCCGAGAATGTTGCAGTGGGTAAAAGACAGCCTGGGCTCAGATGTAGGCCCTGACACTCCTACCTGTGT


GAGTATGTATAGGCAACATCTTTAGGGTCACCCCAGACACCAGCATGCTAAGGAGTGCAGGTGAACAGGGACTTCCAGAGAGTACCC


CACTGTCACGGTGTGCTCTGGGTCTCTGTCCCTTGAGAAGGGTGTTGTCAGGTTTAGGATGTGTTCCCTGAAGGATGGAATCTGTCA


CTTTTCAAGCTTGCTTTCCATTGTCCTGCTCCCACGGAAGGATCTTGGAAGTCCATCCTTTTCCTTGGCTAGTAGATGGTAAGGTTT


GGCCTGGGGACAGCTGCCACATGCTCTTACCGTGTCCATGTGTTGCGACGGTCTGCTTCTGTGCTGTCACCGAGCTTTCCTCTTACG


TGGGGACCCTGTGTGTGCGCATTGTGTGTGTAGGTGCCCCGGCGTGCATGGGTGTGACGTGGACGTCATATCTCAGACGCCGTCCAC


CTTGTTTTCTGAGACTGGGTCTCTCCCTGGCATGGAACTCACCAGTTAGGTTGCACTGGCATACAAGACATCTCCTGTCTCTGCCTT


GTGAGTACTGGGATTGCAAATGTGTACCACTGTACTTAGCTTTTTTTTTCTTTGTTTTTTTAAAGTGGCTTTTAGGGAATCAAACTT


AGGTTCCCTATGTTTGTGTAGCAAGCGTTTTACCAACTAAATTATTTTCCCAGCTAGGGGGTCCTTTTGAGGCCATTTATATCCGCA


TTATAATTACAATTAAATATACATAAGTATGCCTAAAAACTGCTTAAAATATACTGAGTAATAATTATCCATTGAAATAATTTAATT


AAATTTGAAGTAATTTTTTTTTTCATTAAGGAACAAAATAAGCATCCATTTGGCCCCCACTACAAAAAAATTGCTATACACAAATAG


GTATGCTTATGAAATTACTTAGTTTATTAGCATATAATTCATCCAGATTATTACATTCTCTTAATTGAATTTACACTTGTATGCTTA


TAATTTTAAAAATAGTTTTAAACAAGAGGTGTCTACGAGCTGCCGAACATTAAGGGCTCTGGTATTTTTAGTTGTCTGAGAGGTAAA


ATTCTAGGTCTAAAGGGAAAACATGGATGCTATAGTAAAAGATAACTCTCCTGCTCTGTGCTGTGAGCATCTGCAGCAGAGTTTGGA


TTGATTTTCACCTTCTGAGCTGTCATAGACGATTTCTGTTCCTTCCTTGACATAGGAGATTCCTGTAGCTCAACCCTTACCTAGTCT


GAGGCCATCCTCTGCCTCTTCACAAAAGTTCTAAAGGTGAAAAAGTGGGCTGGGGAGGGAGATGAGAAGCCAAAGCTGAGGTTGGTT


ACCACACCGAGGGACGTGCTTGCTTCTTGGAGTTGTGTCTTGTGGATGTCAAAGCCCCTTTCCAGGAAGGGCCTTACTGTTTGCTGC


CGTGATGGGAAGAGTGTATTGAGGCTCGTGAGAAGCAATGGCTGAGATTGGGAGCTGCAGAGGGATACTCATCTATGTTTGGAAGCC


CACACAGGCATTGGGTGATTTCTTGGACAGCGTTCCTGGCGGTTGTAGTGACAGTGAGCTTTACCTGGGCCATTGCTCTGGTTGTTC


ATAGGGAGCAGCCTTCATCCTTCAGACATGATCTAATGTCTTTCTCCAGACAAAGAGCAGCCTCTGTGGACAGTGGGGCCCCAGAAT


CCCAAACATTGCTCCTCAGCTATGATGCCTACCCACTGCATGGACAGCATTCACCTTTGACCTTTAGAGCAAAGAGAACCCAGGCCA


GAATGATGTTCCTGCTGCCTCCTGTGCTCTGTATGGTAAGTCCTTAGTGCCTGGTCCAGAAATCTTTGTCGTCCTCTTCTTCTTCTC


CTTCTCCTCCTCCTCCTCCTCCTCCTTCTCCTCCTTCTTCTTCTTCTTTTTTTTTTCCTGAGACAGGGTTTCTCTGTGTAGCCCGGG


CTGTCCTGGAACTTACTTTGTAGACCAGGCTGGCCTCGAACTCAGAAATCCGCCTGCCTCTGCCTCCCGAATGCTGGGATTAAAGGC


GTGTGCCACCAACGCCCAGCTTCTTTCAGGGTTCAAAAAGCAGACGCAAAGGCGAGGGTTGGTAGTGCCTCATAGCTGGTCAGGTTT


CTTAGCGGCAAGGATGTCATCTTAGATACTTCTCTGTGTGTCAGTGTGCCTCCAGGCAAGCAAAGGAGACAGACCACAGTACCTTCA


GGAATTGCGTCCTGTGTTGGATGAGATTGAAGCTGAGTCCAAGTGTGATTGATTCTTGGTCGTAGAAAAGGAGTCTGACACCAGGAG


TGTGGGCAGCCCCTTCAGGGACAAGCTGTAGCCCATCTGAGGCAAAAATGCAGGGTTAGCCAGATGCCTGGCCCTTAAGAACAGATG


GGAGTGTCCTAGCAAGGTGCTCCTACCACGAGGCAGCAACGGCCTGTCTTGACAGCAGTGGGCCTCTGATGAAACAGGGCCAGAGAG


ATCTCGAAATCTGTGTCTGGTATTTGTAAGTTGTTTTCAGGCACTCAGCCATGCTGTTGGAGAAGGCCTCAGAGCTCACCTCAGAGC


TCACCTGAGGCACGTTAGGGACGAGTTGATGATTGATTCTCAGTCGCTCAGCTGGGCGGAGCCAAGGCTAGTCCTTGGTTCAGAGCA


ATTTTGAGTGCATTTCTTTGTGAGTTCTACATGCACTTGCCATCTGTACTGGGACTCTTCACCCCCCCCCCCCACTCGCCGAGAGGG


ATAATATATAATACAGGTTTAAAATGAAGACTTTAGATGCTAGATGGTAAGAGGTGCCCAGGTAGGAAACCTGATGTGGAATCTTAG


TCCTATGATTTCCAGGATGAATCTTACAGGCATCTAGTCAGACCATAAACAGAAATGACATTTCGTTCACTTAATGATAGGTGAAAA


ATTATTCACTGGCTGTGGCTGCTAATTGAGGTCCAGCATGAGTCAGGCTAGAACTTAGGAAGTCAGGGACAGGGTAAAAAATAAGCA


TGGATCAGGAAGTGGATTTTAATAAGATATCCATGGGAGGGGGACTCTTGCTATGTGAGGGTTAGATAAATATGATGATTTCCACTG


GTGCTGTGCTGTGTGCTTTGGAAGTGGGAGGGGTGGGGAAGGGGAGTCAGGGCTCCTAAAGTGCCACTCTCCAAGCTTTAGCTGACA


TAGAAAGCAGGCGGTGCTTGTAAAGTCAAATGCTTTTTGGCATTTCTGGTGGTGTAAATTCCATCGTGTCTCTACCATTTTGAAGAA


CATCTTGGTGTGGTAGGAGTGAGGGGCTTCTTGTGGTAGGGCTCCCTGCTAAAGGAGAGAGGTGGCTCAGCAAGATGGCTGAGGCAT


GGGGACTTTGCAGAAGGGCCCAAGACAACACCCACTCTGAGTACTTCTCAGCCAGTCCCCACAGGGAACAACACCAAACACTGTGGT


TGCTGAAGCTGTGCCCTTGAAGCTAAGGGAGCATGGAATGCTAGTGTGAATCAGAGTGGGTGTGGCCATTCAGGGACAAAATTCCCA


TCCGTTGGCTGTGGTTCTTTTTATCTTTAGTTAATGATTTCATTCTTTAAAATTAAAAAACAAAACAAAACAAAACAAAACTCCACA


CGTCAATTTTCACATGTTTATGGTGTTGTTTGTGGATTAGTGGTCTGTAATTACCTCAACTCCTGGGCACAGTATATTTGTTATCAC


AGTGAAGAGGGCGTACCAATTATTTTAAAAAGCAATTTCTCTTTTAATTTATGCACGTGCGATATTAGCTAGCTTAAATGCATATGC


ATACAAAGATACGTAGTCTCTCTACATTGACCTGGCTGTCCTAGAACTCAGTACGTCGATGAGGCTGGCCTCAAACTCACAGAGCTC


CACCTGCCTCTGCCTCCCAAGTTCTGGGAACATAGGTATGTGCAACCATGCCTGGAGAAAGATAATTATATATAGCTATTTATTATA


TAGCTATTTTATTGCAAATAATTAAAGGAAAGAAAGACTTGAATATTAACATACTTTTCATTGCCATTGAACATAAATTCTAAAATG


CTGAAGTTTTTTTCCAGGGGTTTAGAGAGGACTGAAAAGACACTTAAAGTAGGGCTGTTCCCAACTTCACATCCAGGTACCATAGTT


GCCTACTGTCAGCGCCTATTTCTGGGTTACCATTTGACGTGCGACACTGCCCATGCTAACTTCTCCTAGTCCCTTGGCTCCTGTCAA


AGGAGCTACGTCAGTGCATCAGATGCCTCCCTAGGAGCCTAGAGGACCTGTCCTGTTTGTCACCTGCTTTCCCTCTGCCTCTCTACA


GACACACAGGGCTTGTATTTGACAGATTTGATAGTGGGAGTCAGAAGCTTTTGGTATCAGAGGGTTGGAGTTTGAATCTGTCTGTCT


GTCTGTCTCTGATGGTGGTGCTGGGATTCCCAGCCATCATATCTCTTGTTTATTTAATAGGAGAGTTATTTTGCCTCCTGTTAAATG


TTCGAGTCTTGGTTTCCTTGAGGATCAAGGGTGTGTTGGGAGACAGTTCTTTTAGCTCACTTGTGTTTTTGCATGGGGGTTGGTTAG


GGTGTTGGTTGCTTTTGATCTGAAGGATGTCTCTATAAAAAGAAGCCTAGTAAGGTTGGTGACAGTCACATAACATTTGGGCTCCTT


AAGCTCAGGAATCCTCAGTTACTCTGTGAGCCCTCGGCAATGTCCTCTGGCAGTCTGGGCTTGGGGAACCAGCACTTGACTTCTGGG


AGCTAAGGCCTGCCTGAACCCTGGATGAAACCCCATCATTTAGGTCTTTTCCTACAAGGACCCAGACAGCCATAGTAAAATGGGCCT


CTGAGTCAGTGCCATTGGGGGGGTCATTATGACAGGGAACTATGGATCCTGTAAGGTGGAAGGAGAGATCTGATGCCTGAACGTTTT


CCTGACTGCTATATGTCACACAACTCATCCCCCCCCTCCTCTCTTGCACACACACACACACACACACACACACACACATTTGTCATA


TATAATACTGAGGAATGTGGGTCAGTGTGTAATGTGTGCTTAGCCGTGGGTCCAGTATGTAACATCACAAAAACAAAACAAAATTCT


AAATTTGTTGTAAAATTTGAAGGGACAGTTAATGTAACTTTTCCTTTTGGTGAGTTTGGCACATGGGGTGTGGATAAGATCTCCCAG


TCAGAAGTGCCACTCGAGGCCCTGTGATTTCTTTAGAGTGGCTGGCTCAGGGCAGCCTTCTTTGTTGTTTTGGAGTCTGCCCTTTCT


TTTCTCTCCCTGAACCCCATGTTCTACCTGATGATCTTTGAGTCACGGCAGATTGTTTTTTAAGGGATGTATCAAAGTTGCCTTTAA


ATGGTTGACTTACAAGCTGGCTGTTAAAGCGAGTTTTACAGGCTACCAGATGAGATGGAGTCAGTGGTCTGGCTAGGTGTACTGTTG


CAACAGTTTTAAAAGACAGTGCCAAGATGAAGACATCCATCAGCAACCCATTGCGTTACATAGGGGTCCCGTGGTAGATGGTACCAT


CACAGTTCCTTGTCATGATGCCCCCCACCCCCCAAAGGTGTCTCACTTAGATCTTTCTGGTCCGTGTGGGAGAAGATCTAGATGAGA


GACTTTCATCCTAGGCTTCGGCAAGGCTTGGCTCCCAGAAGGCATTCCATAAATTGTTTTGTACGCCTGAGTGACTAAAAAAACATG


AAAGTGCTTAGTTAACTGTAAAGTGTTAGTTGCATGTGAATTACTATCCCCCCATCCCTGTCTGCAAAGTAGACCGATGCTCAGGTG


TGGCAGAGGAGAGCCAAAGGAGGAGATCTGGGGTGATGGAAAGTGGCCTCCACACTAGCCTTCCTCTCCTGAAAGGTTGACAGGCTA


GGCTGTGAGCAGTTTCCTCCCTCCCTCCCTCTCCTCCCTTCCCCTCCCCTCTCCTCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NCCCCAAAGGTGGAACAGTTTCTAAGGAGCAGATGGTCCCAGCTCCTGTTATCCATTTATAACAACCCCAGAGATCTTTCTAAAGGA


TGGGTGTCGTTCATCTCTTTTACCACTTTCATCTTATAGACTTTAATTATTTCTACCAAAATTCTCCCCATCACGTTTCTGTCTTCA


TCTGTAGGGATTTTATCTGGCACCATTTTCTTGTGTCCAAAATATCTTTTCTCCCAGAGCTATAGGCTCCTTTCATGATTCTTGGGT


GCTTTCTGGAACCCTCTGCTGAGTGAGCTGGAATATATCTGGTAGGATAAGGGCAAGGTCACTATGTGCTTTTAGAGTCTGTCCTTG


GGACAGAGAAGCTACCAAGGAACTCCTTCCATGTGTGGGCTGATTTCTGCAGCAACCACTTACAAGCGGCACAGGTGAAACCATTCA


TTTAACGAGTGGAATTTATAACAAAGGAGAAAGGTACATTTTCATGCATGTCACTTGATAGTATTTGAAATAAAAGTTGTCATTAGT


TTCTACTGTCATGATGATTTTGTTTTAATTAACAAATTGTTGAGTGTGTTTGTGTGAGTGCCTACATGTTAGCGGGAGGATCAGAGC


AGCGCTTCCAAAGGCCAGATCATTTCTTCCACTGCGGTTCCAGCGACTGAAGCCAGGCTGTCAGGTTTCTGCAACAAGTATCTTTAC


CTGATGGGTTCTGTCACCAGCTCTGGTTGTTCTGTAAGTGTCTGGGAATCCTTGCTTTTCTATGTAGACCAGAGAGTCTAGATGCTG


TTAGGATGTATTTCTTCATATAGCACCATATAACTTCGGAGGTACTGGTTCAGGGTGGCTCCACCGCTGTAACCTTTGCGGCTCCTT


TATCGGATTTCTCTGCAAGGATGACTGTCAATCATTGTGACTTGTGTTTGAGAAACAAAGTTCTTCCTCAAAATGATGAAAGTAAGC


GTGGACTGGATGTGATTTTAAGATTTTCAATTTGGAAAAGCACCCAGGGTTCTGGTGCTCCGTCTGTCTATAGAGGAAGGCTGATGT


CATCACTCAGCGTCACTCAGCAACTTTGTCCCTGGCAGTGCTACTGGGTGGCATTCTAAACAGGTCACCACATACATGGAGAATTAC


TGAGTAGTTTAGGGGGCCGCGTCTTGTTAGGATCGCTGAACAGCGCGGTGATTTATGGATGTGGAGAGCTGTGGCAGGGTAATTTTT


AGCATTTACATTTCATTTTACCACAATCTCGAGGGAATTTTGAGGCTGCGTGAACAAGATTACAAGGCCACCCTCAGGCAATTTAGG


ATTATATAAGGAATCTTCTTTGCTCCCTCACACCCAGGCTCCGTCTTTCTAGCCCACCCAGAATCCTGGTAACCTTACTCCCTCCCA


GATTGGGCGTGGGTCTGTTAGTCCTTCTCTATTGACACCACCCTGGTCCAGCTTCCAGCCTCTCCCTGAAACTGTTACCTACATCCT


GATTTTCTTCTATGGTCCCTGTAACCAACACCTGTGTCAGTTTGTCCTTGCCCCAAAAGTGACCTGTCTCCCTTCCCCAGAGTTACC


TTGAGGTCTTATGCCTTTCTTCCTTCCTTTCCTTTTCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTTCTTTCTTTCTT


TCTTTCTTTCTTTCTTTCTTTCTTTCTCATTCCAGCAATTCCCCTGCCTCCCAGTTAGGTTAACCCTTAGAGGATTCTGTCATACTT


CGCATGCCATTTCCTTCCAAGTATCTTATCCTAACTGGGTCAGATCACTGTTACATGTTCTGGTGATTAATTGGGAACTAAGCGTTC


AGTTTGAAGCGGACGGAGCCATTAATAGTTATATTCCACGCCCACAGAGGGCCTTAGATAAGTGCTCTGGGAGGTTTGGTTTTCAAT


GATCATGTGGTTTACAGCCGTAATCCCTGCAAAATTCTTAATACTGACCCCTTTGACAGTTAGTAATTTGAGGTGACAGTATGTATG


GTGATCTTTTTTAAAGTCCCAAGGTGTGAAGCCGTTGAAGTAAAGGACGGAGTTCTCAGGCTTCCAGAGATGGAGAACGGGCTTGTA


GGTGATGCGGTTTTATTTCACTCCTGACTGAAGATACATTTTGCTCTAAAATCTGGCTTCGTATGCAGATGCAGAGGCTTTTTACAT


TTTGAGGAGGGAAGAATATTCTCTGTGCACCTGGGATTTTGGAATGTGATGACGAGGGGCCCTGGGCTGTTACAGAAATGGCAGATA


AACAGAGGGTGGTGAGGGAGGCCCTTCTGCCAGTCAGAGGCTGACAGATTTGATCAGAAGGGGTGGAGGCTGCTGCTTGTATTTTGG


GTAGATTTTCTCGTTCCAAAGGGACTTGGTCTCTAGGTGGCCATTAGTGAGGGGAGTTATGTGATCAGTGGGACCATCTGATAGTGT


CTGTGTGTGTGTGTGTGTGTGTGTGATTAGTGGGGGTGGCATGTGATCAGTGGGGGCTTGTTACTAGCTGGGCCACACGATTAGAGA


GACTGATCATGAAGGCCATGTAGTGAGTGGCGGAGGGGGGGTGCGGGGGGGGGAGCTGTTTGGTTCATTGGGCCATTGATGAGGGTG


GGTCATGTGATCAGTAGGAGCTAGGTGGTTAGTGGTGTGCCAAGGGGACTCGGGCTTCCTTTTCTGTGCCCATGTATACTCAGAAGG


TAGGGTAGACAGTGCCCAGTGAGCTTGATGAATCAGAAAGAACTTGAGGCCCTGGTTTCTAAGACCTGCTCTCAGGACATCCCTGGA


GACTCAGTTCCTCCCTTTGACTCCTGCTGACATTGGCCTGCCTCAGGGAAGGCTCTGAAGAAAGGAGGCACAGCATGCTTTGCAAGG


TACTTTCAAATTGCTGGGTCCCTTCAGGGGAAAAGAGCCTTTTGTGACACTGGTCTAAAGATAATTTTTATCAGATTCTGTAGCCTG


AGGTCTCAATAACAGCAAAAAGCCCTTCCAGGGCCTGGCTTCCATGGGGGTTGGACCTGATTGAAGTAGCGGATTCCTTCATGCTGG


CCCTGCAGCAGGCCCAGGTACCCCAGGAGTGTTTCCCTGAGAGAACTGTACAGTCAGAAGGAGGTGCCAGAAAATGAGATGAACGTG


CGAGCCCTGGCAGGTCGACTGTGCTTGCTAAGGGCAGGTGTGTGCAGTTCTCACATCACGTATCTATCTCCACAGGGTCAGGGTGGA


ATATGCTCATGACAGGTCACATGCAAATGAGGTTTAGAAGGACGGGCTCTGTTTCATTCCTTTCTGAGTATCAAAGTCATGGGACAG


GGTGTGCTTCACTTGCTGTGGAGAATAGAGCCACTCTAGCGTTCGAATGTGGGGGATTCACAGGGCTCATGATGATTTGCCAGCTAG


ATGATTCAGCAGAGTCTTTGCAAGGTTTTGCTAATGGTTAAATATCTACAGCAGGCTGAATTTGGATTGGCTGAGGGACAAGGTGAA


ATAAGGTAATCATAGTTACATGATTTTTTTTTTCTTCAAGTTCTGGCATCTTGTGTTCTCTGCCAAGCAGAAATATTCCGGCAGAAT


CGTGGTAATGCCTCTCATCTGCAGGCTTCCAGATGGCAGCTTCTCTGCCAGCGAGCAGAAGAGAGCTTTGGAAGCCCAGGGGTATCT


CAGTCCTTTCCTCGGTGTGACCCAGGGAACTCTTGTTCCCTGTTTGTACAGGGTGCCGGTGTCTCTTCAAATGCCTTGTATGAGGCC


TGGTGTGGTAGTGCACAACTGTTATTCCAGCATTTGGGAAGCTGAGCCAGGAAGATTCTTAGTTCGAGGCCAGCCAAGGCAACATAT


TGAGATATTTTGTCCCCACTGGAAAAAAAAAAAAAAACCAGATAAAAAGCCATCAGATCTTAAATTTCAAAGTTGAAGGGTGCCATT


TTCCCAATAGCAAATGACCACCTGAGTAGAGCCTGTCAAAGGCCTTCTCAAGAGAACTGTCATCTAAGTGAGCCTTGTTTGTTACAG


ACAGAGGCACTCCCTCCTGTGCGCAGCACAGTACACACTGCAATGCTCCATGAACACTGTTTTTCTAGCTGTGACTCACCCTGTGTC


ACGCCCTCCCCAGGCAACCATTCACTTTAGTGATGTTTATAGATGCGTTTGTCTGGGGCTATGAGATAATTGGGTTACATCTTCTAC


TGGGGGAGCCCATGGGGAGGGGAGGAAAGACACACACAGAAGAAAGTGGTGTGTAAGCCTGAGGGTGGGGCAGAAGTGAGCATTTAA


GGTTGTGCCAGTTGAAGGATTTTTAGGGATTTGCTGCACACAGCGTTGGCCATATTTCCCTATGTGTTCCAGCAGCCTCTAATAGCT


ACCGGCCTTCTCTTGAGGGTCTTGGTTTCGGTCTTCAGCGTTCTTCCCCTTCAGTCCCTTTGAGAACCTTTACAGACTACCCTGGGC


GTGCCCTACGGAAGCTCTTACACTGTTCTGTGTAGATACTCTGAAGCAACGGTTATTTTCCTTGCTAGCCTCGACTGTAACTCACTG


AAGGCAGGCAGTCACATCAAATGCAGTTAGTACAAATGGCAGGCTCGGGCAGTATTAGGGTCAGATAGACCGTGGTGACAGACCTTC


AACACCACTCTTAAATATAGCAGTGTGTGTGATTTTGAAAACATGGTGCATTCTGTAGGCCTGGGGAGATGGCTCCGCCAATAAAAT


ACTTGCCTAGCAAGCAAGAGGATGGGAGTTAAGCTCCTGCTGCTCACATGAAAGGCCCAGTATGGTGGCATGTCCCTGCTATCCCAG


TGCTAAGAATTAGAGACCGGGGATCCCTGGAGTGTAGTGGCCAGCCACGCTAGCCAAATCATGAACTCCAGGTTCACTGTGAGAACT


TAGCTCAGAGAATAGGTGGCGAGCAAAAGAGTAAGGCACCCAACCTCAACCCCTGGTCTCTACACACACACACACACACACACACAC


ACACACTCCTTATGTGCATACACACCATTGTTTTTGTTTGAGAAAAGCACAAACTTGTAGGCTGCCCATCATCATTTACTTGATGTC


TGTTCATTCATCCATTCTTCATTCATTCGTTCATTCATTCACAGGCTATACCTTTTTTTTTTTTTTTTTTATAAGACCAGATTTTTC


TCTTCAGTGATATTTTTTGAATCTTGGATATTTTTACTGCTCTGGGGATTTTCTTTGAACTTGATAATTATTTTGATAAATCTTTAT


CACTTAGATGGTAGCTTAGAGTTAATTCTTTCTATTAAGTACTTTTTAGAAGATAAACCTTTGGAGAAATCACCACATTTTATTAAT


GACTTGTGAGACTTAGCAGCGACTTACGTTGATAATAATGGAATGCGCTTTGGGTAGAAAAATTCTTCTTGCTGACACACCAAGGTG


GAGATGAAGATGTGTGCAGATTGTTAATTTAGGCCAGTGTGTCAAGATAACAGAAGGCTGGCAGTAGTCTCTGTTGATTTTTCTCTT


GTAGCACCTAAGAGGCAATGGGCACAAGCTTGTGCATGCCAACTTGGACAGCTCTCCATGAAGTGCCTGCGGTATTCTTCATGTGGC


ATGGAGAGGGCCTGCTGGGGTATGGAAAAGTTATGGGGCTTGCCCATGGCCATGGTTTCGTGCCCACAGATAACCCCTCCAAAACTG


GAGGTTTCTGGTTATACAGTATAGATTTACAGTTGGAAGAGTTTGTAATTGTTAAACAATAAATATTCTTTTGCCAGTTGATGCTCA


ATGCTTCTTTTAAACAATATATATATATATATATTTATGATTATTTAGCATTGCCTTTCTTAGTTGTGCTAAGCTGTACATAGCTGT


GACAGTTAATTTCGAACCCATTTGAAAACAATGTTGTCACGTTTTCATTGCTGAGAGACGTTCAAAGCATCATCATTTCCAAAGCAA


AGGATGGGCTTTGCCTTTGCCACTGGTGAGGAGAATGTCACGTGCAGAATGTTAAAGTCTTCTTTAACAGTAAAAGCTTCTACTCAA


TACCAGCCAACGTGTGCTCTCCGAAGCCTCTCTAAGACAGGATGTGTAAGATACAGATGCTGGTCAGGGCCTCGTAAGATCTGGGGT


TGTAGGCTGCTGGGGGTAGGCAGTCTCGGGGATGCAGTGTGGAATGCTGGGTATGTATTGTGGAGCTCTGGAGTTCATACAACTCCT


CTGCCTCATAGAGGGATGGTACTTCCCTCTAGTTGGTAGTTGATCTGGAAATGTGTGTATGTGTTGCCAAATCTAACCATCTTCCAA


TAGTAGCTGGAACTCCACATACTTTCAGTTCAGAATCTATTAATTTTAAATCTCAAGAAGAAAGAAAATTCAAATTAAAACAAACAT


TAGACAGCCCTGGGGGTGGAGGTTGACTTTGGAACCTTACTGTATCAGATCTGTGGCCTGTCCTGTTGGCACCATGGTCACGTGCCT


GCTTTCATTGTCCTTTGAAGACTTGGCGATACTCTGTGCAGCTATGGCTTCCCATGACTGCCTGCAAGTTCATTTTTTTTCCCCCTG


AAAAATGTAAGTGTTCTCTTCCACCGGATAGAAGACTGGGGGGCCTTTCCTGAGTCTCAGTTCAAGTGAGTAATCACTCGGGATGTT


TCTCTCGTGCGTTTGTGCTTTTCTGTTCTGCTAGGTAACACATACAGCTTGAGTTAAGGGGTCGTTATCTGGGCCTGCTCTACATTA


CACAGGGATTCTTATAGCTGTGGTGTTTGTTGTAATGAGATTTGACCTCCCAGGGGAGCTGTAGATGCTTGGGCGAGTGTTCAGTCC


TTAATATTGGCATCTAATTCTAGGCATGTTGCCTGCAACTTCCAGTTTCAAAAAAAAAAAAATCTATGTCAATCTGTTCTTTTATAA


CCTAGTGCAATTGCTTCCCCCCTTTTCCCCCCAACACCCTGTTTTATATTTAATCATTCTCTGCGGCTCGCAACACCAGACCAGTCC


AAAGATTTACTTTTTCTATTTCCAACCCCATCATTAATTTTATGTAAAAAGTATGTTTTGAGTTAGAGCAATTGGTGGGGATCAGGC


TTGGACTCTGTGGGGAGAGGAGAGATGTCATTTACAACAGAGTTTATACAGATGAAATGTTCGCTACGTGCTGAGTTCCCACTGTAA


TCCAGGGGGTTTGTTTGCATTTACACTGAAAGAAAAAAGATGACCATATTTGGGCTGACTCTAAGCCAACATGATATAAGCCCCAAA


GTCTTTCTTGGAGGCCGGGGTGGGGTGGGGGGCAGGGAGCAAGGTGAATAGAAACATTTGGAAGCAATAGTTTGTTTCCCTGTTTTC


TTTGCATTTCATTCAGAATATTTCATGCGTGACTCAAGTTTTATAGCCTCCTTTTTTTTTTTCTTTTGGAAACAATGTCAAACCGAG


AGGGAAGTTTCAGAGAAAAACGGAGCTCTGTGTCCCTCCGTATGACTCGACTTCCCAGGTATGTCCTCACGGTGGCCGGTGCGCACC


TCACACTCCCATCTCCTGCCTTACCTTGGTTTTTGTGAATCCTTCCTTCCTTCATCTCTCATGCCAGTGACTGTTTTGATTTCTGAG


GTGAGGCCTTAGTCTTCAGCCCAGGCTGGGTTGCAGCTCCCTGCAGCCTTCCTCAGCCCCTTAAGTGCTGGTTTATGGTATGAGTCA


CCATACCTGGCCTTGGTTGTGACATCTTTTTTTTTTTTTTTCTTTTGGATGATGATGGTGTCAGTTGATGGCACAGAATATCCTTCC


TTTCCTCAGAGGATGTTCTCTGTTCTCTTCCCGTCCTTCACTACTGGCTGAGCTTGTGTTCCATTCAGTGGGAAAGGCAGGGTGTGT


TCATGAAGACCTGGAGTTTCTCGCCTCTGGATTACTACAGTGATTCCTTAGTCAGATATTCTTTATATGGGTATTTATTTATGTGAT


GTTTATTCTTTCACCTAGTCAAAACACACACACACACACACACACACACAGACACATGAGTTTTGAATTCATGGGTTCAATTAATGG


ATCAAAATATTTTGAAAAACGTTTATAGCAGGGTGAATGGCAAGTACCTTTAGTCCCAGCTCTGGGAGGCAGAGGTCATTGGATCTC


TATTACTTTGAGGCCAGCCTGGTCTAAATATTGAGCTCCTGGCCACCCGGGACTCCATAGTAAGGCCCTGTCTCAGAATGCACACTC


ATATTTATTGATTATTTACAGACCGTGTGTTATATCATTTCCTAAACAGCATGATGTAGTGGATATTTCCATCCAATTTACATTTCC


TGGGAATAATACATAATCTAGAGAAGATCTAAAGCGTATAACGGATACACTTAGGTCCTGTGCAAACAAGATACCATTTTATGGAAG


AGGCATAACTATCCAAGGACTTGGTGTTCTGGGGAGCCCCAGAACCAGTTCTGTGAGGAAGCTGAGGGACAGCTGTGCTCTGGAACT


CCTGTGTGCCACGTGGCCTATACTCAGGAGGAAAGCTGGTTAGTAATAAAATCCTGCCCTCGTGCAGCTTAGGTTTTAATGGGGCTA


ACAAATGAATAAGTCGTAAATAAGGTAGATCATGATAAATGCTGGAAGAGAGTCAAGTCAGGGAGGGGAGGAGGGAAGGGAGGAGGG


AGGGGAGAACAGACAGAGACCGATGTTCTTGATAAGAGGGCAGGGAAGGTCTCCCATGAATTTGATTATGGAGCAAGGATCCCAAGG


GATAAGGCCTGGGCAGGGAAGCCTCTGGAGTGAAGGCTTGTTGAGAGGCATCCTGGTAGCTGGAGCCTGGAGGGAAGAGAAAGGTGT


TGTTCCAGTGTTGATGTAAGGGAGATGAGAGACCCTGGGAGAGTTTTGATCCCGGAAGCTGTAAGATCTGACTTGTTGTGCCTTACA


GAGAACACCTTTTGTTATGTAGAGCAGAGCTGGTGAGGGGCAAGGTTAAAGGCAGAAGAGAGAAGAATTAAAGCAGGGTGGGGTAAA


CTGCATAGTGGCATGTCCTCTTGGGACATCTGAGGCACTCAGGGGCCATCAGACTTCTTCATCATCACCACCACCACCATCATCATC


ACCACCACCACCATCTCCACTATCATTACCATCACCATCATCACCACCATCTTTTTTGAGTGTGCACCACCATCCTTGGCTGAGACT


CGAACCTAGAACCAGGCAAACATGCGGCTCTCCAGTTCTTCCCGCCTCTCTCAAAGTTCAGAGCACACCGGGCTTTCCTGGGCTATC


TGTAAGCAGTGCTGCTGGCTGCTTTGCCAGGAACCTGGAAGTCTTTCGGTCTCACCTGTGTTAGTGTGAGAGCGGTCCTTGAAGCTT


ATGTTGATAGACACAGGAGCGAGTTGTTTTGGGATGAGTGAGTGATTGGGTTCTGGAAAGTTCTTTAGAGACACTTAGCTATGAAGT


GTTTGCACTCTTACTGTTTTCGTTTTCCAAGAACACATTTCTTAGCTTAAAAAATGTGGTCCTATGAATTTTCTCTCAATATTTATC


TGGTACAGAAGGCTATCACTAGGCACAGCATTTTTTGGTTCTTTTTTGAGAGAGAGAAGTTACGTATTTTATGAACTGAACACAAGA


CTCTGACGTCGTCGTTTTCTTTTTCTTCCCCTGGACACTTGGTTTTCAGGCAGAATAAATAAATGCTACCAACAGGACCCACCCACA


GAGAAGCTATTAAATGTTTCAGTAGGAAAGTCGGACTCAGGGGGTAGGTTAAATGAAGCTATTAAAGATGGATAAGAGAGAGAACAT


GATGTTGGGCCCAGTGGGCCAGGTTGCCTGCCCCTTGCATTACATCAGAACCTCAAGGAAGGAGAGGGTTTGGCCCTCTGACCAAAG


GCTGTTAGGGCCAGCTTTGAGGCACATTTGGTTCTTTTGTGAATTAACTTCCATTTTGCCTGAATAATGTTGGGTCAATTAAGAAAA


AAATGAGCCGCGCTTTACCCGGGCGATGCTAAGGTCAAGGGTACACATCCTTTGGAACCGAACTGGATTTGAGTCCCGTTCTGGTGG


GCAAGGCGTGTTACCTTGGCCTGCCTCCAAGGGAAGAACAATCAGTACCCGCTTCCTAAGTTCACTGAGTTAACGTCCGTGCGGCAC


CGTCGCGTCTGACATAAACCCTCAGCAATTAGCCTTTCCTCCTCTCCTTCCTGCTAGTACCATTGTTACCGTCATGAGCATTTTTCA


GTGACTTCAAGTCTATATCTGCTTTCTGGAGTACAGAACACTCTCAGTTATTGCTCTTTGGGGTAAGGGTAGCCTGCGTTGGTCATG


CCTGTTGTATTCCTGCATCCTCTGGTCACAGGAGGTGTGCAGTGTTTGGTATTGTTAATCCCGTGTTTACGGCCAGCCATGGCTGGA


AGCAGCCTGCTGCCCGTGTACGTCTTTTGCCTTTGTCTCTCCCTGTCAAAGAGGGATGTTCCAACTTCCTTCAGGGACATGTGGTGA


AAATTAATGAATAACTTAATGTTTGCGACTCTAGTCCATTAAGTACTAATGAGCATCCGTTACTATGCTGACAGTCTCTGAGCGCTA


GCATCGAACTGCTCTCCGAAGCAGGGGCATTGGTTGAAAGGGCTTTCCGTTATCTGGTGTGGGGGAAGCTTTTAAAACATGTCCCAT


TGCTTTATGTGACTACCGTTCTCCATACCCCAAATTCTAGACCTCCCTTGCCGGAGAAGAAAGAACTCTAATGGAGCAACTTCTCCA


AGGGTTCCGGTAAGAAAGTGCTGTCTCACGGTAATTAATTATGTTTGGGGACCAGCGCCTTTCACTTTTGACACTTACACTTGGTCA


TCTTATGTGAACTGCTTGTGTCTGAACTCCCCAACAGCCTTGTAAATTTCTTGTCACAGATTTATGATGGTCTTGGGTAGCCAAGAC


TCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTACACCTATTAAGTTTGTATTAAGTGTCGTATTAAGTCTTTGTATTAAGCTTG


TGCTGTAGAGGCAAGATTAGGAGATGTTAATATCTACTATTTGGGGATAGCTATTATTAAATGTAGCCAATACAGTGATTTTATTAT


TATTATCTTAGTGTGACTCTATTTGATGATCTATGCAGCCAAAGAAGGTGTTTCTTTTGGGTCTTAGTATTGTAATGAGATTTTTGC


CCAACGTAGAGTTATCTTAAATAACTGATTTCCAGTGGACACCTCTTCCACCCATTGATGAGATCTTTTAGAGAATGTGAATGTATG


TGTGATATTCAAATTAGGTAATTTAGTGGGCTGCTGTTTTACTCTTCCGGGTTTGGCATGGACATTGTACCACTAGGGAAGTACAGG


GTAGCTCTGGATGGGTCTGGTTCCTGAGAGGTCCCAGGACTGGAACCCATGAGGCCCCCTCCCTGGACTAAAGCTGATTCCTGCTTT


CTTCTCGAAGCAGTGTTTGTTTAATCCCCAATGTTCCCATGATTACTAAATTACAATTCAATCTCTTGAATCTAAAGGATTAGTTTA


CTCTTGATTGATGCATAAAACAAGTTTTCTAATTTCTGGAACTGTGTCTAAGGAAAACCTCTGAACTGTAATTTTGCGAAAGGACAG


AGGATGTTGTTATAGATTTGGTCTTAGGAGCCCCGTCTTTCGACTGGACGCTGTAATTAAGTAACCTGCTCATCAGTGGGGAGGGTG


ATAATAGTACCTGCGCTAATCTCTGCTAAGCTCAGTGATCCTTTGAAGTGGGGTCCAGCTGTCTCCTCCCGGTTTCAGGTCCTCGGG


GAGAAACAACAGAACTCGCTAAGGACCCGAGAGGACCCTGTGCACGCAGACTCACCAGGAAAAGACAGTTTGAGGGTGGATAGGGTT


GGCAGCTGCACTGAGGCGTGTTTGTTCGCCAGTTCTGATAGCAGGTCAAAGTAGTTTAACCTCTTACACAGCAGTGAGAGGCACCAC


TTCCCATTCTGGCATCACTGACCTCCCTCTGAAAAGGGACAGGGAAACATAGAGGAACGGGAGGGCGCTTATCTTTCAGGTATCAGA


ATTCAGACCAGTTTCAGATCGCCTGGTTTTTAGTAGTTCCATGACTCTCGTTGTTGCTGTTTCCCTCTACTCCAGCACTCCGTTTTG


GAGCTCCTAAATGCTTAGGTCAAGCATGCTCACCCACCCCAATTCTTATTTTTGTTTGAGACATTTTTTTTTTCCTACCGAATCCCG


GATGACCTCATTTCTAAGCCAGAGTAACTGTCTTACCCAGCACACCCATTGAATGTCTTAAAAGGCTTTTCAGATCCATCCATATAA


AACCCTCCACTTGCTCCTTCATGGAAGCCGACTGCTGTGGCCTCACACAAGCACAGCTGTGCTGGTGGGGTTGGAAAAGGTGTCGTC


ATTCTAGGTCCATTTAGACAGGCTTCTGAACAGCTAGACAGACATACAATTACTGTAAGAACCAGCACTCCATGTGTATATTCCCAA


GAGAATGGAAAAAGCAGGCTTCAGATGAAATGTATACATGTGTGTTCAGTGTCAGCATTATTCCAAGTATTGCAAAAGGAAAGGAAA


AAAAAATCCCAGCTGTCCATCAGTGATGAGTCTGCATAAACAAATTGTGATATTCTCGTACAGTGCAATGAAAAGGAGACAGTAATA


GTGTATGCCACAACATGAATGTACTTAGAAAAAGTTATAGTAAATTATAGCAGCCATCTGCAAAAGGATGCAAACCCATAGAAACAG


GGAGAATATCAGGCAGGGGCAGGGGGTAGCGGAGAGAGACAGGGAGTGTATATCAGAGTGCAGGGGAGAGAGACAGAGTATATCAGA


GTGCAGGGGAGAGAGACAGGGAGAGTATATCAGAGTGCAGGGGAGAGAGACAGAGTATAACAGAGTGCAGGGGAGAGAGACAGGGAA


TGTATATCAGAGTGCAGGGGAGAGAGACGGAGAGTGTCTCAGGGGGCAGGAGAGAGAGACAGAGTATATCAGAGTGCAGGAGAGAGG


AATGGGAGTTTTTTGGAGGGATTTGAAAATGTTTTATCATTGGAAAGATATATTGTGAAGCTACCAAAATCTATGAGTTGGCCACTT


AAAAATAGTCTAAGTGTTGATTACAGGAGTCCCCAGGGACAGCTGCAATAAAGTGACACAGGCTGTGAGGCAGGAACAACAGAAATC


TGTGTCTTACCAGTTTGAGAGGTGGGAAGGTGGAGGTGGAGGTGGAGGTGGAAGAGGCCAGATTCCCCTTAAGGACTGAGGGTAGGC


TGTTCCAGGTCTCTCTGCTGCTCCTGGTGTGAACACTCAGGCAGACACTGGGTTGGAGACCCTTCACCCCATCTCTGGCTTCATTGT


CATGTGACATTCTCCCCGTGTGTGTGTGTGTTTGTCAAGATTCCCCTTCTCATTAGGACATTGTCATAGTGGAGTAGTGTTCACCCT


GGGTGACTTCAATTTAACCAATTATACCTGCATTGACTCTGTTCCCAAATGCACTGTGGAGTGCTGCGGTATCACTTTAACATATGA


CTTGGGAGGGGGTATTCAATTTAGTCTATAATGGTGTCTATTATCTAGTGTGATTTACTTCAATTTTTTTAAAAAAGAAAAGTGGCT


GCAGCGATGGCTTGGCAGTTAAAGAGAACTCGTTGCTTACAGAGGACCCACATTTGATTCCCAGCGCATAGAACTCCGGTCCCAGGG


GATTCAACACTCTCCTCTGGCCTCCTGGGCACCAAGCATGCAAGCAATACATAATCACACATGTGGGCAAAGCCCCAACACACACAC


ACACACACACACGCACACACACACACACACACACACACACACACACACACAGTGACAGCGCAAGTTCAAAGTCAAAGAGCAAAAATA


AGAAGGACGTAAAGACATAAAGACATAGAAAACAGTTGAACCCTCCCTCCGTGAACTTCAGACATCTGAGCGGCTCAACCCCTTATG


GTCTGACATCATGGCCTCTGCTTGCCTGATTCCTCTGCCAGGCAGCTGGTTTGTGTCCACAGCCTGATTCGCTGTTCCGACTGATGG


AAGTCTCTTCACCCTTAGAGTGCAGGCCCAGTGTCACACTGCAGGATACTGTCCCCTGTGCGACCTCTCAGTGTAAGACTGCTGCCT


CTTGGTCACATGCAGCACTGTGTGGGTGACCTGCCACCGTGTGACGAAGCACGGGTCAAACAGCCACCTTTCCTTTACAGATTGTGT


GGGTCAGGAGGCCAGGCAGGGCAGTTGGGTGACCCCTCTCTCTGGTATAGAGCCTTGATGGGAAGATGAGGACACTGGGGAGGGGGC


GGGGGCAGTTCCAGGTGTGTGTCTGCACTGGCAGGACTTGAGGTGACACTCAGCACTTCTGCCCTGGGGCCTACGTGTAGCTGAGAT


GCCTTCACAGCAGTCGGACTTCAGGGTGTTCACACTTCTCTCAGGGCTTTTAGAGCTCCAAGAACCAGAATTCCAGGCACGAAAATA


AGCAAGAAAATGCATGGCCTCTTCAATCCTAGCCTCAAAGTCACATGACATCATTTCCACCATAGGCCTGCCCAGATGCACAAAGAA


TGGCCTTAGGTCTCAGTTCTCCGTGAACAGAGAGTCTGAGGCCGCCTTTATTAACACTCAGTGCTACCTTGCCCCAGAGTCTGAAGC


CCCTCCCCCACGAAGTCATATGTTGAGACCTATTCCCCACTCCTATAATACTGTACCCTGGGGCTTTGATGATACGGGATGCCTGCC


CCCAATAAAGGAAGCCCAGGGTACCATCTAAGAAGTGGCGAGCGGTTTCACATCCTCAGGTCCTGTGACCCTGGATCTCTCAGCCTC


CAGACTGTGAGACGAAATGTCTGTTGGTTTTTAGTTACTCCTCCCTGGTAATTTCACTTAGCAGTCACCTGACAGACAGCCGCTAAT


CAATCTGTGCTCTGTCAGGTCGCTCCTTGGTAAACCGCTCACTTCTTTGCATCATTATTTAATTGATTTTTGCTTTTCCAGTGAGAG


GGTAAGCTGGTTTGTTGTTGTTGTTGTTGTTGTTGTTGTTGTTGTTGTTGTTTTCTGTTGGATCCTGAGCTTCTTGGTGGCTGGCAC


AGAGAGCAGGAGCTTGGTGAACTGATGGAAGGTGAAAAACATAGAACCAGAAAAGCCATAAGCATGATAAACCTGTAAGGCAGGCTC


AGTATGTGTGACCCACGGCTTGGTTGGATCATCTTCCTGGTCTTGATTCTGCAGTCAATCTGAGGCTGCCTCGTGAGCTGCGGAGTC


TTGTTGACGCCCGCCATTAGACACAGCAACGTAAGTAAAAGTGAGGCCGGCTGTTTGCTGAGTGCTTTCTACAAAAGCGGATAAACA


GAATTAAAAATTTAAGGTTTAAATAGGCCACCGCTAATAGGGCTCATGCGCTCATGGATTTGTGTTTATTGAGTAGAGGGAAGGTAG


GATGTGGTACAGTTTTTTAGTTTTAACAGCCTGCCTTTGTCAGAGCTTTATGGGGCTGATCATGTTTATTTAACACTCCCTGTGGGG


CTTAGCATGAGAGTCTCTCATCTGTTGGGCTTCTCATTTCTTTTAAAAATTCTACTTGGAGGTAGAGGCGAGTGTAACCCTGCAAGA


CATCGTCCGCTTCTTCCCCGGTTTCTGCACAGCTGCCTGACAGCTGCCTTGGACTTGTTAGGTGAGTGCCAGTCTCCTTTTTTTTTT


TTTTTTTTTTTTTTTTTCCTGTAGAATTCCAAGGCAGGGTTTGCACAGGACCCCTTAAAAAATGCAGGGTGAGGCGATTCTGTGATC


GAATGTGCAGTTTTTGTTTTCTCCTATGCAGCAAAGACCCCCACCCAACTCCCCAAGGCAGTGCAGAGCAGAGACAAAAAGCACTGA


CTACAGAATTGCTTGATCCCAAGTGTGAACTCTGACCCTATCACCTTTTATTGGTGTAACCTCAGGCGAGTTAGGCACCTTCCATAT


GTCTTCCCTGAGCCCTCCATGACAAGGAAGGGGGATGTCTGTGAAGATCCAACCGCAGCCTGTCGTGTGGAGAATGTTTGGGGGAGT


CCTTGAATGGCTTTTAAACACTGGTCTTATTCTGGCTTTGTTCCCATTGGAAGGAAAAGCCTATGCTGTTTTAGGCTTGGAATATTA


GTATATAACTGAGCTCCTTGAGGATTTTGCTTTGAAAAGCTTCTATTAAAGAATAAACATGGGCCGGGAGATGTTGGCTCAGTGGTT


AAAGTACGTACTGCTTAACCATAAGGACTAGAGTTTAAATCCTTAGCACCCATGACAGAAAGCCATAGGCATGGTCACTGCCTATAA


TCCCAGCACTCAGTAGGCAGAGATGGGTTCCCTGGAGCAAACCAGTGAGTGAGACATGTCAAATCCATGAGCTCTGCATTCGATTGA


GAGAGCCTGCCTCATAAATAAAGTGGAGAGCAATCGAGGAAGGGCCTTCATATGTACGCCCTTCCCACCCCACCGCCCATATACACA


GGCACACCACAGAATGAGGACGTTTGGAACCCGAATGTACTTTTCTACATTTCTCTACCATCTGTGACAGCTAGCTCATGCTGCCAG


GTAGAATGTGTGGACTTGTTTGTTTCCTAACATTGGATTTAAAGTTGATGGCTCTTCCCCTTCAGGGCCAGGTCTGAGTGAGCCCTG


TGGACGAGAGCCCCATACCCTCTGTTCAGAAGACCAAAGATGGCGGCAGATGCTGTGGCTGGTGAAGTGACGTCAGAGGAGGGAGGA


GGGACGAGGGACGAGGGCTTTATAACAGATGGTTTCTTGGATATCTGGGGCTTGTCCAGTTCTAAGCTTTGAAAACGATGGGCCAGA


CCCTGAACTGGCACAGACCCAGGCATCGTTGCCAGAACAGGAAGTGAGGTCCTAGAGTGATGTCTTTGGGACAGCTGCTGCTGCTCA


GCTGGTGGGCTGGCACAGTTGGCATTGGCTTCCTGGGGTTTAGTGAGGTGAGTGTGTGTGTGTGTGCGCGCGCGCGCTACAATGGCA


ACAACGAGATGGGAAGCTGAGAGGGTCGTGACTGAGTGGGGTTATCCTCTGATTTACGAGAGGTGTCAGGTGCGGTACCATGTGATA


GTTTTGCCGACGTTGGCATAGATGGAAAGGTGTGACTGTAGAAACCAAAGATCCGTGCATCCCACGCTCATCAGCCTGGAGTTCAGG


CTTGTGTGGAGCACAGAGTGATGCTCTGTGGGAGGGCTTGGCTGTCCTCTTGACATTAGCCTCCAAAGACTAGGAGCCTATCCCAGA


CATTGCTAACATCCTCTAATACCCTCTTGGAGTAGTTAAACCATTCTTGGCTGGATTCTAGTATTTATCCTGCCTCTCATTAGCGGC


ATGTCCTTAGGCAAATTATTTAATCTCTCTATGCCTGGCTAGTTTTGTCTATACAATGAAAACCTGGACTGGATGATACATTGCTTA


TGTCCAAATATAATTTAATAATATTTGATTTGTAAAAAATATATTTTAGTGTTTTCTTTTAAATGTGAGCTTCATGAATTTTGTTTT


AAACACACACCTTTCTTAATTTTTTTTCTCTCTTAAGGATTTAGAGAGTGCTTTTCAATAACTAGTGTTGACGTGTTTGGGAATTAG


AGTTTACTATCATCATGTTAAGGATCTATATTTTCCCTGTTTCTGTTTCTATATTGTCTTCTTCCTTTCATTGTTGGGAATAACACT


AGTTGCTATCCCTCTTGGAGAGCAAAGGCCCAGAAAACAGGCCAGAGAACCATCAGGGCTTTTCCCTGGAACTTAGAGGCTACCTGG


TCAGTCGTGATGCTGAGAAGAGGGAGATACTGAGGCCCTAGAAGGTTTGTTTTTTTTTTTGTGAACAAGACTGTAAAGCATAGACTT


CTTGACATCTTGACTCTTTAGCTTGCTTTTCTCTGCTGTTTCGTGGCATTTGGCAGAGTGATCTGAAAACGATCTTTCACACCGGCT


CTCACCTGACAGTAGGAATGGTGTCTGGTCCTCACCCAGGTCCAGCAGCATTAGGGAGGGCTGCTGTCTGGTCCTCACCCAAATACA


GTAGCATCATTTTAAGGTAGAACTAACTTAGGGGCTCCAGGTTCCTCTTGAGCATGCTACCTCTCAGGGACCGAGCTCAGGGCTTAG


GTGTCTTGACATGTGAGTGGGGAATAGGGGGCATTCTATGGAGTGTGAGAAAGCCGGGCTAAGGGACTTGTGTTCACATGAAGCTCA


GAGACCATGGTGCAGTCCTTGCTCACATAACTGGTGTCAGTAGATGGCTTGCTGGCCAAGTTCTGTGGAGTTGGAAACTGTACTGGC


TGGTTTCATCTGTCAACTCTGACACAGGCTGGGGTTATCAGAGAAAGGAGCTTCAGTTGGGGAAGTGCCTCCATGAGATCCAGCTGT


GGGATATTTTCTCAATTAGTGATCAAGGGGGAAAGGCCCCTTGTGGGTGGGACCATCTCTGGGCTGGCAGTCTTGGGTTCTATAAGA


GAGCAGGCTGAGCAAGCCAGGGGAAGCAAGCCAGTAAGGAACATCCCTCCATGGCCTCTGCATCAGCTCCTGCTTCCCGACCTGCTT


GAGTTCTAGTCCTGACTTCCTTCAGTGATGAACAGCAATGTGGAAGTGTAAGCCAAATAAACCCTTTTTTCCCCAACTTGCTTCTTG


GTCATGATGCTTGTGCAGGAATAGAAACCCTGACTAAGACAGAAAGCTTCGAAGAGGTTGATGTGAGTCCCGGAAACTGGGTTCCTG


CTTGCAAGTAACCCTTCTGCTTCGCAGCCTTCCTGCACCCTCCCAACACCCCGTAACAGTTCACACAGCTCTGCAGCCAGCCCCATT


CCGTTGTTTCTCCTTCAGCCTCTTCTTCCTCACTGGACATTTTCTTCATGTTAAAACATGAGTTTATTAGTAAATTTAAATGTCTGA


AATTCCAGCTACCTCAGTGCCCTTGTTAGCCTAGACTTGACACAGCCCAGAGTCAATATGAGTCACTAACTGGCTTTGTCAGTTTGG


TCTGTGGACAAGACTGTCAGGGTTTGTGTCATGATTATTAATTAATGCGGAGAGTTTGGGATGGCCCAGCCCACTATGAGCATCACC


ATCCCTAGGCAGGTGGTCCTGTCGACATGAGTAGAGCTGGCACAGCATGGGCCTGAGAACAAGCTGGTAAGTACCATCCGCCATGAA


ATCTGCTTCAGATACCTGCCTTGGATTCCAGCCATGATCTCCATCATGATGGACCCTACCTGGAAGTGTAAGATGAAATAAATTCCA


TTCCTCCCCJGTTGCTTTTTGTCTGACTCTGTTTTATCACCATAACAGAAAGGAAACTAGAATATTTAAAGAATCAGTTTGTCTATT


TGATGTAGTCATTTTCTTTTCACTGAAACCACTGTTAGGAAGCCTTCCGAAAATCTGAAAGACCAATAGGTTGAAGATGAGATTCTG


TCAACAGGTGGAAGGTGAGGAATTCAGAGAGGGAGAGGAGAGAGAGGCCAGCGTTTGCCATACAGGACAATTTAAGTGAGGGAGAGA


CTCACTGTGTTATCAGGTTCCACATCTGAGTATTCTGATAATTCCATCATACTGATAATGCGATCATTCTGATAATACTATAATAAC


ATCCCTGATAACTGCAGATTTTATTTTAATTTCTGTTTTTAATTTGTATCTGTTCTGGACACACATAAGdTTCTTTCTGGGTCCTGT


AGTATACAGAACTGTACTGCAGCTATTGCAGGAGTGATGGCTCTTCATTGAGTAAATAACCTAGAGATGATTTCAAGTCTACCAGGG


GATATGTAGAGCTTATATGCAAACCATGACGTTCCGTTCAAAGGACTTGAACACTAGAGGGTCCTGGAGTCAGACCCTCACAGCTGT


CCAGGGACGATTGACCCGAGGGTTTCAGGCTGGTGTAACTTACTCAACAGCAGCCTTTCAAAGATTGGTGAGAAAGTTTCGACAGTA


GCTAGGTTTCAAGGGGCACAGACTGCCCAGCAGGGATGCTGTTGTTGCAGATTGCACATGGCAAAGGATAGGAGCCTTGAGGGTAGC


TAAGGATAGGAAGGGTGGTTCTTGGCTAGGTCTCATGGATACTGGACTGGCAGATGTTTCTAGATCCACAGCAATACTGGGAAATAG


TTTATGACTAATAATTGATCAAAGTCTCTGCCAAGCTGACGGTGATGGGCCAGGAACCATCATTTCTGTGTATGTGGAACTTGAGGT


ACATGGTTACGGGCTGTTGGGCATCAAGGTGTCGTCTGCATATGCCTGTGGTCGGAGAGAACAGGTGGAAGTGGGCTGTGGGGAAGC


TGGAGCTCAGACCTCACGCCCACGTGCTTTCCCATGATCCTCCCGACATTTAGTCACAGAGACAAGCTGGCAGGATGAAACGAATGG


TAGCATTCATCATCCAAATTTAAATTTGTTTCTCATTAACAGACATTCTGCCTGTAGTGCACCATGAATTAATATGTTTTATAACTC


TTGTAACTGTCTCGTGGAGGGCATAATTAGTCATGAGTGTTTGGGTCTTAGAAATGTTAATCTGTTCAATGTAGGCATTGAAATATT


GCGTCGTTTCTTTATTTTTTAACATCTCTGAGCGCTCTAAGAAGATGAGAGTGGCCGTGGCCTCTCTTGACCTCTGGGCGGCCTGCT


GAGCCGCCTCTGCAATTGGCTGGCCCGGGTCATGTGCTCACTTGTGGTCCAATCAGCTGGGATGGAGGCATCAGTGTATAGAAACCT


TTGACCCGGGGTTGTGAATCAGCTTCTGCCTTCTGGAAATGCTACCCAAGAGCACAGGGGGTGTGCAGAGGGAGGGAGGNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNACAGCAGAATTCTGATTCAGTCCCGAGGCTTTGAAGTTTCGAACTCCGTTCCTTTAATGCA


TGCGTAGAGTGCGGGTAGATCACGCAATCCCTGGGGACCCTGCCAATCACGTCCATCCGAAAGATCAAGCCACTGCTAAGCTGCTTC


CTTAGAGTGAAGTGATTGTTCAGGCTGTTGGTTGTTGTCTCAGAAACGCTACAGAATAGACAACTATAAGGGGAGGGAAAAAAAAAA


AAAAGCAAAACAATTCCAGAAACGAGGAGCGGATAAAGAGATGCAAGGGGCCGTTTAGTCAGCTAGATGAAGACTGGAAGTGATAAT


TGGCGGTGTTTAGGGAGGGTTAAAATTGGAAACCAACGCGAAAACGCAGTTTAAGCCACTGTGTGTGTGTGTGGGGGGGGGGGGGGT


TCAAAGTAAACACTTGATATTTGGTAGTTACAGACACACAATTTTAAATCGACACAGCACCCTCCAGTGCTCTATTCCCCCAAGTTT


CTCTTTATAACTTGTAATAATTTATTCCACAACCACCCTCAGAAGATAGCTTAGGCTGGGCTGGACCGCATCCGATACCATGTTTGT


TGTTTGGCCAAAACTTTGATGTTTACGGAAGGGGACCAGAGGCCTTTATAGGAAAAAACACAAAAAACCTGGCGTGTTGGCAGATGT


TGAAGTAAGCAGTCCTGGACCCTGCTGTGTTATGAAGGGAGGGATTTTGGACCTCAGTGTTCTGCAGACACTACATTTGCGTTATTA


GAAAACACAGCACCATGGATAAAATGTTGGCAGCTCCTACAATAGCCTGGCAATGTGGTTTTCTTGTTCATTCACAAAGTCTCCTTG


TGCTTACTGAGACCAGAACGCACCGCACCGGGTGGGTGGGGCTTACTCCTGGACACCTTGAGATGCCTCAGGAGGGTGGAGCACAGG


CATGGCCTGAGAACCTGCTTTGCTTCTCTGTGTCCTGACAGTGCTCACCAGAAATTGTAACATTATTGTGGATTTTTCTTGAGACCC


TTTCTATCGAGCTATTTACTGGACCTTGTTATTATATTTCAGTATATTATTTTGCCAGGAAAATGTCAAGTCCATCGACTCACTCAT


GCAGCTCAAAACGAAGCAGGTTTTGGGCCTCCTCCTGACCAGTTGAGACTGAACCCTCCATGCTGGGCCTAGGCCCTATGCTGCAGT


GTCTGTATGCAGTGCGTATTTGTGGAGGCCATAGAGCAGCATCCTGTGTCACCCCTTATATATTTTTGGAGACAAGGGTCTCTCACT


GAACATGAAGCTCACAATCTGCAAGACTAGCTGACTGGTCAGCAAGCTCCAGAGGGTCTTGTCTCCACCTTTCCAGTGCTAGGATGA


CAACATTTGGATCTATCATGGTTGTTCTCACCTGGAAACTGGGGATTTGAAGTCTGGTCCTTATGATTACAGCAAACATTTGACTGA


CTAAACCCTGAGTACTGAACCTCAAATTCTTTTGTCTCTTCTATTTTCCTGTGTTCTTTAAGTGACTGAATCCTGAGGTTGGTGGTT


GTCACTGTCACTAAAATGTTGGAACAAAAAAAAAAGACAAACCAATTGTGGTGGTTTGTATATGCTTGGCCCAGGGAGTGGCACTAT


TAGGAGGTGTGGCCCTGTTGGTGTAGGCGTGGCACTGTGGTGGTGGGCTTTAAGACCCTCTTCCCAGCTGCCCAGAAGCCAGTTTTT


TGCTAGCAGCCTTCAGATGAAGATGTAGAACTCTTAGCTCCTCCTGCACCATGCCTGCCTGGATGCTGCTATGCTCCCGCCTTGATG


ACAATGGACTGAACCTCTGAACCTGTAAGCCAGCCCCAGTTGAATGTTGTCCTTTATAAGAGTTGCATTGGTCATGGTGTCTGCTCA


CAGCCGTAAAACCCTAACTAAGACACCAGTTCTTGTGTGCATGGTGATATCTGTCCATCTGTCTTAGAGCTTGATAATAAATATGTA


AATACTTCAGAGGGAAGGAAAAGTCTCATAGTTATACATTAGAGTTATTGGTGCCAGGAAAACTAGGGCCCGGGAGTGGGGCAAGGT


GAGCGAGTGAGAGGAAGGAAGTCTAGGTGAGGAAGAAGATGCACTATAAACTGAGTGCTGCAGAAGAGCTAGGCGTGTGTGTGTGTG


TGTGTGTGTGTGTGTGTGTGTGTGTGTGTAGGCCAAGGCTGCTTTTACGTGGGACAGTGTCCCAGAGGGCCTGATGAAGGAAAGTGG


AGGTGGGGTGCTTGAAGAGCTAGGCTTATGGCTTTGAGTACCATGTGTGAAGGGACTGTGACCCTGGGAGAGGTAGCCTTGGTCACT


CTGTGCTGGTGTCTCCCCGGTTTCCTTGGTCCTGTGCTTTCATAGCGACTTGTCAGCTTTAGCTCTCTCCCTGCTAAGGAAAATCTC


TCGGCTGTTGGCTTTGTTTGAGGAGCTGTAAATGGACTTCACCTGAAACACATTACAGGCACCGGAAGATTAGTTTTAAGCAAAAGA


ATTTGATTGAAGGCCGCATCTTGTTCTTGCAAATCCTTTGATGTTTGGCCATTGTCTTGTGGGCTTTTCATTTTGCTCATTGGCAGC


TCCGTGCAGTGCTGGGCTGTAAAAGCCTTCACCTCCAGCTTGTCTTTGTGGAGTCTGGAGGTGGCTTCCTCCTCCCTCTCCCCCTCC


TGGGACAGCAGAAAGCTCACCCAGTTAATTCTTTATAACAAACTATTCTCTCTTTCCAGGGAAGGGGTTCTGGGGCATTTATTGGTA


GGTTGTGGTTATTCCCTGGTCTGGAGTCAGGATCCTAGGGAATCATTGGGTCGAGCCACATGCAGTATGGGACAGAGGTATGTGTGT


GACCTGGTCAGGAGGTTCTAGTGCTCTTAGCTGAAGACAACACAGGCAGAATCCTCAACAGTGGAGCCACTCACCACCCTCCAAAGG


TCCAGACCAGGACTTGGGGCTCGGTCAGCCCAGAAGAAGCGGGTGTCTTCTATTTGTTAGAAAACCACTCCAGCCACTCAGCCTGGA


GAGTTCTAGATAGCTCTGCCTGGGAGACAACCTCACTCAGTAAGCAGTGGGGATCCCAAGAAGGATCTGTTCTTACTTGGTGGAGTT


GGGGCTGGCAAGCAGTCTTTGCCTCCTGTGACAGAGGCATCCCTGAATAGAGTGGAGACTCAGATCATGGCAGAGTGAGTAGCCTGG


ACCTGGACGAGGAGCTGAGTCTTCCTACGGACTACCCTGATGACTACATTTGTCACGGTGTCTTAGCCAGTAATATAAGTGACTTGT


TTCTTTAAGAGAGTGACTTCAAGGTCAGGGGTATGGCTCTGTGGGGGAGCATTTGTTCCTTCTGTATAGGATCATGGGTTTGATGCT


CAATACTGTCCCTCTCCCCAACACACAGAGAGAGGGTGACCTCAAAGATAGGTGCCTCATGTCAAGTCATATCCTACAGATTACAGC


AGTATCCAGGGGCCTTGGCAAAAGTGCTCCTCCCCAGGGATCGGGGCTATATGCCAGGCTTCTTCACCTATGGGTGTTTCAAGAGCT


AATTAATTTGCGCTGACCTTGAACTCCTTGCCCAAAGCAGTCCCCCTGTCTCCACCTTGGAAGCCATACCAGGCAGCACTGAGGGAT


ATAGTTCTAAAAGGGTCAAGAAAACTCTGGGGGCCTAGCTGCCACATGGGTCCTTGCTCTTCTCTGACCTGACATCAAGGTGGCAAG


GGACCCCAGGTGAGGTGTTAGCCAATAAAGACAGAGTTTCAGGCCTGCCACTGTCATATTACCATTTGTTGACAACCGTCCTTCATT


AACCAACCTGTTCTTCACACATTGGTTCGAATGTGCTTCTCGGATTTACTTCATTCAGTTCACCAATATGCGGTAAGCACTGAGGGG


CCCAGTAATTGGAAGTGTCTGTCGATGGCCTCTGCCAACCTGGCTCATGATGAAAGTCCTACTTTTATAACTCAGTGTCAAGCTCAA


TAAGAGGGAGGCCGGTTCAGCTATTGTCAAATCTCATTGTTTTTCCTACTGGGAGGACCACAGTGGGTTCAACTGGAGACAGTTGCT


GTCTGAGCCCAAGGTCCTTCTTTGTAGCTGGGCTGAGGACTGCAGGTCTCTTTAGCCTGTACACATGGACAGAGGGCCCTCCTGCTC


TGCATACCAAGAAGCCATGCTGGCTGTCTCTCCCAAGCTCTTCTCTGGCCACTCTCCTTCCCCCCACATCTGGTGTTTGGAGGAGGT


TCTCCTTTCTGAGGGCAAAGGGTACATAGGGGCATTAGTCCCCTACTCGGAGAGGTGAAGGTAAATGGCGAAGAAATTGCCAGAAGC


ATCCTTTTAACATCCTCCGTGAGCAAAGCTCGGCCTGTGGAGTGGACTGGTACCTAGACTCCAAATCACGGAGGAGTGGCTACAGCT


GGAATCGGGATTGTCTTTCCTTGGCCACCTCTCTTGTCTCCAGCTGTCCACCATTGCTACTGAAAAATGGATTTTGAAGACACCCAT


GTTGGGTGACTGTGTGTACCCGGAAGCACCAGTGGAAAGGGGTACACAGACACCACATCTTAGTTTGCCTCCACAGCTGAACGGGCC


CTGCCTGCTTTAGTCTGGATTGTTTTTCTCTTCTGCAGCTCCAAGTGGAGTGAGCAGGACTGCTTTCATGTCCTGTAGCCTGAACCT


GCCCTGCTATGTCCCACTCTGCGTGGTGGTCATCTGTGGGGCTTGATCAGCTGCATTTCTAACTAAATGGTTTTTTTTTTTTTTTTT


TTTTTTTTAGTTGAAGTCATTGTGGCACCTGGACTTGAACATCTTGCTCTTGTGTTCATTGTTGTTTTTTTTCTCCCTCTCCATTCC


TGTCACCAGCCTGTAGACCACCTTGAATTCACTCCAACTTGCTGTATAAACCCCTCTAGCATTCCAGTGATAGAGAACTTTCTTAAA


AACAGAAATACACACAGTTTATCAATATCTGTGTTTTTTTCTCCCTGGAGGAGCAAAAAAAATCAAATCACCACCACCACCACCTCC


AAGAAACCAAAACCAACCAACCAACCAAGCACCAAACCAAACCAAAAACCAATTTAGATTCAGGAGCGGGAGAAAGGAAAGAAAATG


TTTTTGATGATGTTAAAGTTTTGGACTTAGAGGCAAAAGTCCTCGAACTATTAGAACCAGAAAACACTGCATACTGAATAATGTACA


CCCTGAATGCATACCTGTGGTTCAAAGGTGTGGGTCTAAATGGCTAGTTTCCTCTCTAGCAGCCCGGAGGTGTTGCATTCATTCCTT


TTGGAGAGAGACATATCACTTTTAAAAAGTGGCTAAAAATTGCTGGAGACCCATTTGGAGACAGGATATTTGGACTTCATTTGGCTG


TTGTCGCCAGCCAGTGTTGGGACCTGGTAATAAAGCCTGGGCTTTTAGCGGATCCCTGGGATAGGGAAAGAGCTAGACAGCATGGGC


CTGGGAAAACTGTGGGCCACCAAGACTCCATTTCAATGCGAACTTATTCTACCAAGAGCTGCTGTAGCAAGAGGGAGGAACCTAGAT


GGAGCAGGGGTCTCTGAATGCTGCAGGCTTACGTGTTAGCATCTGGAGGGCAAGAAACACCAAACTTTAGCAGAGAAGTTCAGTGAG


TTTAAAAACCATAGATTCAAGGAGCTTAAGGAAGAAAATAGTTCCTGTTGTATGGGTCCATATAGGTCCCTGTCACAGGTATCCTAG


GAGAGAGCGAATATAGGTCCCTGTCACGATATCCTTGGAGAAGAAAGGGCATATGGTTCCTTGTAACAGATATCCTTGGAGAGAGGG


TACATGGGTCCTCGTCACAGGTATTTGGTGATGGGGAACATATAGGTTCTTGTTACAGGTAGCCTTGTGTGTGTGTGGGTGGTGGTG


GTGGTGGTGGTGGTGTAAGGATTCATGTCACAAATAGCCGAGTGGAGAGACAAATGGGTTCCTGTCACAGGTATGGGGGAGAGACAC


ATTGGTTCCTGTCTCAGGTATCCTTGAGAGCAGACATGGGTTCCTGTTACCGGGATCTTTGGGGACTACATGGATTCATGTCACAGA


CATCCTTGTGGGTGTGGGTGTGTGTCTGCACCACAGTCTAGAATCCTGTGAGTTCAAACAGACGTGGTTCATTCACACTCCTGCAGC


GTGTCTCGCATGTTACGCTATAATGAATCAGGTTCCAAGTTAAAACTGTTTTTCGTGAAATCCTGTGGGGAAAAGTGTCAATTTATG


GATAGGTGCGGTGTATATAGATTTCATGTAGAGCATACCAAATGGTTTTCTTTTTTTAAAACCATGCGCTCTAATTACAGATGGAAA


GTGTCTAAGGAAAGTTGGACTAAAACAACACACACAGACGTATATATTATATATAAAGATGGACATGTGTAAATGATAAAATGCTGC


ATACAGGAAAGGGGAAGCTGCCTTAGACTATCAAACCCATTACAGATGAGCATGATACTTACATGAGAGCCTCCTGGAAACCAAGGC


AAAAAGAAAAACATGGTGGATGATAGGTCTCTAAGTATCCCTCCTCCTCCTTCTTCATCTTCATCCTCCCCCCCCCCTTTTTTTTTG


TACTGAAAAAAGAAAAGACCGAGAACCTTGTTACATTCCTTAGGTTGGCACAGATGTATTCTGTAGCCTAGGCTAGATTTGAACTTA


CCATCTGTCCAACTGACCGACCATCCTTCTATCCATCCATCCATCCATCCATTCATCCATCCATCCATCCATCCACGCACCCACCCT


TCCGTCCGTCCGTCTGTCCATCCATCCACCCACCCATCCATCCATCCACCCACCCATCCATCCGTCCATCCATCCATACACCCATCC


GTCCACCCACCCACCCATCCACCCACCCATCCATCCATCCATCCATCCATCCATCCATCCATCCTAACCTAATTAGCTGAGATTAGA


GGCCTGTACCACTAAGCCTTCCTAGAAATCTTTCTTCAAAAAACAAAACAAAACGCTACACACCTATGTCATGCCATGAGGTGAGAA


ACTCTGTTGCTAACCTCTGAGATTTTACAGCCTGTCGCTGATATGCTTTCATTCTGGCTGGCTTTACCAGACATCCAGAGGTACCAC


ATTCTCTGACAGCTTCCCAGCTGCAGTTGGGTTTTCATGGGAGTCCTGAGAGGTTCCTCTCCTGGGCCTCAGCTCTGGCTCCTCAGT


GAGCTTAGTTCTCTTCCCTTAGCTTTCAGACTTACTTGTGGGGCTGCCAGGAGCTGGACAGGCTGCACTGAGGAAATACAGGGAGCT


GGGGATGGTGGGGGTGATGGTTATTCTACTCAGAAAATGGCAGCTCAGAAGCATGTGATGGGTCTGACCGTGAAGGAGGGGCCCAGC


CTTCCTACCTGAGGGAGCTGAGCTGAGGGTGGGAAGCCTTGCTCCAGCATCCCCTTTTGCTTCTCCATGAAGTCCTGTGCCCGCCAT


CTTCCTCCAAATCAGTTGCCCAGCGATTATTCAGAAACGCCTTGGAAAGATGAAAGTGTATTTTTAACACTGGAATGAGAACACAGT


AACGCTTTTGAGCTTCAAATTGGATTGCTTTACCGAGCTGAAGAGTTCTCTTTCTTCCTTTAAAAATACTCGCAAAATTTAAAGAAT


TAAAGACTCTGGGGCTAGGAATGTAGCCCAGTTGGGAGTATGCTTGCTACTATGCTGAAGCCATGGGCTCTTAACACAGCACAGCAT


TAGCATAGAGGGGTGTTGCACACTGGCAACGCCAGCAGGAGGAGGATCAAGAGTGCAAAGCTAGCCTTGGCTACATGAGATAGATAC


TGTTTCAAAAACAGCATCAAGAACAACTCAGATACCCCGAAGGGCAGGGAATATGTGCTCAGTACATGGTTTCTTTACCTTTCCTCC


TCCTTTGGAATTTGTAGTTGGAAACCTTTAAGTAGATTTTATATATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATAATTTAAAA


CCACACTCTGCTCTGTCTAAATCTCATAAGCAAGCACTAACTACTCCAGCTCATTCCAGTTTGTGTTCTCACACATGGAACTATGGA


GTGCATATAGTATTACAGTTATACTTTGTGCTGTGGAGTGCTTTGTGGCTTCTTCTCATGGATGGGTCTATGCAGGGCAAGCCGTTT


GATAAGAAGGTCTGTGCTGCTTCCTCTCGGTTCCTGGATTGGTGGCAGAGATTTAGTGGCTCTGTCCTCGTGATAAGGCAGGGTAGA


ACAGCATTCTGTGTGTGAGTCTGCTCAGCATCACCAACATTCATCCTTCTAAGCCTTTAGAAAGCTCAAGAACTCATAGAAATAAAC


CCTGTTGTGTTGTTTGGTACCAAGATGAAACATAGCCAAAGCTTGGGGGATTAGGACTGGGAAGGTTCCCAGAAGTAAATCTCAGAC


TTTCTGGATGATATTCCACCATGGCTTTTTGACAAAAGAGCAAGGCCTCAATGTAAGGCTCAATGATGACGTGTGTCTGTGTGTGTG


TGTGTGTGTGTGTACATATCTATCTACCCACTCACCCACCCATCCATCCATCCATCCATCCATCCATCCATCCATCTATCTATCCAT


TCATCTACCTAGTGTTCTGTCTGTCTATCTGTCTGTCTGTCACCTCCCCCTTTTTAATCCAGACTCAATGTGTTTTCACACCTCTCC


AGGTGAGCATCAGGCAGGGACAAGAAGTAGCAGACAGAGTGGCAGCTCAAAATGACCTAAGTAATTGTGGGTGGTCAGGAAAGTAAC


TGGTTTTTAAGTTCCTTCTGGGATTGGGCCACCTCAGAGAGTGCATGGCTGGGTGGGCGTTGTGTGGCTGGCTTTGCCATGCTCTGG


GGGCTGGATCCCACGGCCTGTTGCAGAGCCATTAGTGGGTTCAAGGGGAGGTGCATGGGTGGGGATGAAGTCAGAATTGTGGAGCAG


GTGATGCAAGCACTTCCCTGAAGAGCCATCCCACTGCCTGGCCGCCTACCTGATGACACCACCCAGCGTGGCTTGTGAACGTCACGT


CAGTTCATTGCCGCACAGACACTTTTAATTTGCACAAGCCAGAAGATTTACACTGGGGTTGAGATAGCAGAAGACGAAAAACCCAGT


GGGTTAGTTCAGAGCTCTGACTTTGTTTCTGTTCCTCACCCTGGTGTGAGATGGCTAAGCAACAACAGGGCTAGAGTTCAGATCTAT


TGACGGCATACTTGCCTTGGTACCAGAATTTCTTCCTTTTGAAGTAGTTTAAAGTTTAAATTTTCTTCTTTCTATGTATGGGTGTTT


TGCCTGCGTCTGTGTCTGTGCTGATAGAGATATCAGATCCCCTGAAACCAGAGTTACAGACTCTGGGGCCGGGAATGGAGTAGTACA


TTAAGAATGCCAGTGCTGGGAACTGAGCCTGGGTCCTCTGGAAGAACAGCTAATGCTTTAAAGCACAGAGTTGTCTCTCTGGCCGCT


CCGTGGCTTGAGCTTCTGAAACGGGGTTTTTCCTAGAGGTCCATGGAGAATCTCCTTCAGCCACACCGTGGACCTCTGTGGTACTGA


AGATGCGGCACTGAGGAGCGTCTGCAGCAAGCTGTGTATATTTAGTCCTAGGAGTGAGGATGCTAGACAAAGAGCTAGGTAGAGTGC


AGTGTGGAGGAACTGGAAGGTAGCACGGAACAGTCTTGGTGTAGATGACAACCTGTAGTTTATGCATGGCATCCTGCTGTTACTACC


GTGGTGCAAACGACCCACGAGATGGTATAAAAACCTGTGAGTTCTGAGGTGCAGAAGGAGGAAAGAAACTAAAGAAGCATTAATGGA


GGGAGGAGGCAGAGGCTATGATGAGGCAGGTCTAGCCTGTAAATCCAGTGAACTTCCCACCCTAAACTGACCTGAGTTACCCTGCAA


CAAGCATCCCCACCTCCTGCGATTTCAAGGCACCCATATGTCGCTGTGTGTCGCCTGTCACTTCATCTGGAAGAAGAGCATCCATGT


GGAACATCAGTGGCACCTGTCTTGAAAACTCAGGGCCACTGTTGGTGAGGGGACACCAGTTCTTTGCATAGGGTACCCTCTGGTCAG


ATGGCCTTCCCAATCCGTGCAAGTAGTTTAGCAGGGGAAGGTGTTTTGATTTGCGGCAGGGTAGACAACATGAAGAATGTGGTTTTG


GGATTGGGACACCAAATGGCCACATTCTGGGACTTTTTATCTGGGTAAGGTTGGGCTGGTGTGAGCATTGTGTATCAGGCATTTACA


GAGACCAGGGAAAGGAGAGAGGTATGAGTAGAGCTTTGTCAACAAGAAACCTTGACACAGCCAAAATGGATAAGGAGCTTTTCTCAG


TGTCTCCTGTACCATAAACTCATTCCCTTATCCCACTAGTGTTGAGAATATCAGGTACTCTGTAGGCTAAAGGACACTTGTAGGTCA


GCCTTTAATTATTACATTAATCACAGTATGGAGTAGTACATTAGCTTCTGAAAAGCATGGAGGAATTACTCCAAATCATTTAAAACG


CGTATCGGAAGAAACACATTTGTGAATATAAATAAAAGCATTATTTATAATATCACAAAAACCTGTAATTGATCCAAGCATCCCTCG


CGTGGTGAATGGTGGAATACTACTCAGCCACAGAAAAGGAGTGGAATTCTGAATGTATATAGCAGCATGCATGGGCATGCAGAAGCA


TTGTGTACATCCAATTAGATGATACTCCAGTGCAGACAAAAGTAGTCTGTGCTTATACAAAGCAGATGGATGAATGTCTGGGGCTCA


GCATGTAGGGGTCAACAAGGGAACTTTGTGGCAATCGTGTACTGACCTTGACTGTAGAGATGGTTGAATGGTTGTATACACTTGTCA


ACACACTTAACTCTACATGCAACAGGAGTGGATTTTAAGTGAGTTGTATATCAAAGTATTTTTTTAAAGGCTCATGTTTAAATGTAA


GGCAACTCCTTATAAATTTTGTTATCAATTATAGCTTTTTTTATCGGTAGGAAGGAGTTCAAGTTTCAAAGCATGTAAAAGTGACGT


TTTAGATTATAATCTGTGCAAAACGGGGAACTGTTCATATGCTCAGGCTATCACTCCATTTTAATTCTCTCTAAACAAACTTCTGGA


TTCTATTATTTTCAGAGGGCTTTGGAGACCATTTTAAAGTGCATGTTTTCCCAGGATTTTCCTGTACCTCTTTGGCAAGCTTCATAC


TTACATTGTTTCAAAAGTATAAATAACAGCAGAAGAGAGCTCTGTTTTTGGCATACTCCTTTGTCCTTTCCTGTTGTCCTGATTCTT


TTATGTTAAATCAGCCTGCAGTTCCCGTCCCTTCTGCCTTTGAACTTAGAACATGGGCTCCCGGTCCTTTGCAGGCAGACCCAATGA


AGAGAAAGCATACTGTGCATGGCAGAAACTGGGTAGGACAGAATTCGGGTGCCTGCCTGCCCAGAGCGAGGGTAGTGAAGTGTGGGA


GCAAATTGCTACTTGATAAGCACTTTGGGTTTGGAAATCTGGTGTCACCCACCTGTGTCCCGTGTGGTAGCGCCTATTCTTTATCCT


CCCCCCCCCGCCCCCTCGCTCCTCCTCCTCCAGGTCCTGTGGAGTCAGCTACTTAAACTCATGGTCTAAGACCTCAAAATTTCACAG


TGATCTGTCGTCACAACAAATCTAAAATAATAAAAGGTAATTATGTTTCTGAAGGTACCAGTCTTTTGCATGCTTAGGACTGAGTGT


GCATTAAAGTGGGCTATTGAGTTTTTGAGGGGAGGGGACTGGGGTGTGATAGTGTGTTCGGGTCTAGGGCCAGGCTGTATGTGGTCT


ACCCTACGGTTGGTGGCCTGGACTTGCCCTTTTCCTAGAAAAAGCAGATCAGAAAGAACAGGCAGTTCTGGCCCAGCTTCTTGACGA


TCACCTTTAACCCCCTCAGTGCTGACATCTGGGCTGATGGAGCCCGGGCCCTCTTGGGGATGTGGTGTAGGTCAGGAGGCTTGGGTG


TTCTGCCCATCAGGGCCCTGAGGAACCCTCTGTTTTTGGGGAGATAGCTTATTTTGTGAGCTTGAGGAACTCAGCTCTGAGTTGAGA


ATGCCATTTCACAGGGTGTGATACTTAGCCATGTCAACTTCCATGAGGTTTACGGTCGCCTAGGCGACAAATCTCTGGGTGTGTCTG


TGAGGGGTTTTCTGGGTGAGGTTTACTAAGATGGGAAGACCCACCTAACAGTCAATAAAAAGGAGACCGTGAACTGAGAGGGAGCAA


GTCTCTTTATGCTTCCTGACAGCAGATGCAACCAGGCCAGCTGCCTCGGGCTTCTGCCGCTGTGACTCTCTGATAGAATGGACATCA


CCCAGTATCTGTGAGCCAAAATAAGGGCCCCCTTCCTTAAGTTGCTTTATCAGGTACTTTGTCACAGCCAGAGGGCAAGTAATCACT


GCAGAGGGATGTCTAGAACATTAGATGTGATGAGGGAGTGTGGTAGGCCTTTGTAAACCCTTCTCTGTTGGGAAGCTGGCTTTGGAC


CAGCTGCCGTGGAGCCGAGCCGACTGCCTGGTAACGCCTTGTGATGTCTGGTAACGCCCTGTTCATTTTGTAAATCCAGGGGACGCG


GAGGGACAAGGCCAGAATAATTTGCAGTCACAGGTGCTGCTTTGTTAGCAGCACAGCCTTTTTGAGATGGGGACAGTGTCCCTTCAA


TTTCCTGGTTTGCTCTGCACGTCAGTTTAATACACAGGCATGTGACTAGAATCACAGACCATGGCTGCCAGGCTCCGAGTAAATGCG


CTCACTGGAGGCTCATTACCTGTGATTGCAGACACAGGGAGGAGATTTGACTGTGGAAATGGAGCTTGATGTGCTATTGAAATAACT


TGGCAGGTCGGTAGGAAAGGCGTGGGGGGTGAGTAGAAGGTGGGGGGGGGCTCCCACAGTGATATCCCCTCCACACATCGGTAGCAA


GCAATATTGTCCCATCTGATGAGACATGCACTGTATTTTGTTCTGCTCTACAAATAAGAAAACTCCTATCTATACTTATCACAAAGT


GATGAAATTTTGGGGGATCATGATAAGTATTTTTTAAAAGCTTAATTGTATTATTGGTGTTCCAGCTTCGGACTTATTTCTGGTGCC


CTATAAGTGGCCAGCAGCCTGGTCCCTGGGTGCAGATCTAGGCAGTGGGAGAAAGGAAACAATTATCCAGCAAATGCGAAGAAATCC


TGCCAAGGAGCAAGAAAGACACCCCTCACCCCCTGGCCAATTACAGAAAATTGGTGTTTATAGGGAATTAAGTTGTCTGGTAATGAT


GCTTTCTCTTCCTTTGTCTGGTAGAGCCATCGTCAGAGCCATAAGTGAAAGAAAGCCAGAGTGTTTCCGGCCTCTGTGCTGAGGCGG


TGACCCTGCCTGTAAGCACCCACCTTTGGGGGCTCAGCCGCATTGGGAGCAGGATTGAGCTTACTTCCAGGAGCCTAGTTGACCCTA


AAATACAGTGAAGCGAGTGAGGTGTGTTTATTCCAGCTTGCTGGCTCTGCTTGCTATGCGGGAACTTGGTGTTCTGGTGTACAGCTG


TCTGGTGCTAAAGATGACTTGGGTCTGGGTTGCAGCCCGTGTCGATCCTGGGAAACTCTCTTCCTATGTTGGGAACATTGAGAGGGT


CCTGGGGTGTGACTCTAGTCTCAACAGCGCTGCCTTCTTACATCACTCTACCTGTCCTGGATCTGCTTTCCCACGGGAACAATGTCA


CGGTACTTTCTAGGCACCGTCTACAGTTTGTAATCTATCTTCTCACCCGAAGAATGGTATGGCACGTGACAGACATGAAGACATCTT


TAGAAAACAAAGCTCTCCACGAGTGTAAACTGTGACTGATGACACACTCAGTGACCTTATCTGAGAGCTCATATTAGAGAGACAGTA


TTTGCATCTTTTAGGGGCCCATGTACCAAGGTAAAGCCGTGGCTTCCCTCCTTGAAGCCCTTTAGGGCACATCAAGATGCCTCAGGG


GACTGAATCTAAGCATAACTGGATTTTATTTGCTTTCCACTTCTCCTTTGTTTAATCTGCTCTGTTCTTTATTTCCGAGTACTGGGA


AGGATAGGAAATATGTAAGATTTTTCATATCAGTAAACAGAAATAAATGGGAGGCCCGTGGAAAGAGAGAAGAGACTATATTAAACA


TATTCAAAGCAAGAGGCAGGAGAAGGGAGTCTGTGAAAGTTGGCAGCCGGCAACCCCAAGGTTCGTCTTAAGAAATGACAGGCTTGG


AGAGTGAAGCGCGGGGCTGTAGCATTTTTGGAAAATTGAAGTTAACACCAACGCTGCCCTTTCTTTGCTCGGCGAGACATATGGCAG


GGACAGATTCCTGTGATCCTCTGCAGTCGTGTGACATTGGCGCATTTGGCTCGTTTTTTTTTAAAAAGGCTCAGCAAAGTCTTAGGA


GACAGAACGCCTCTTTACCTCTTTCATCCTGTGGGCCCACGAGGAAGTTAATTCCTTTTTAACTTTTTGAGACATACTGGTTTCACA


AAACAGGAAAATAAAGGGTCTCTCAAAGGACTGAGATAGACTAACCAGTCTGCAGAGTAGGCAGGAGCAGGCTGAGCGACAGGACAA


GACAGGATGGCTGGCAAAGGGTGTGGTGAGGGCATGGCGGTGGTGCTGCATGCCTTGAGGCCTTGCATCGGATCCCCACCGTATGAG


CATAGGATCACCTGCGGGAGGACACTGCAGAGGACTAGAAAGCTTATGGCCCATGTCAGAGCACCGGGGTGATTCTGTACTGTACCT


GTCCTGCGTACTGCAGAGTTCCTGGTCAGGATTCACTCACATGTGAGTATAGCAGTATGTGCTTGCTTTCCTGGAGCCAAGGAAAAG


GCAGACAGCTTAAGAAGAGACTGAGTAATTAGGTTTATTTAGAAGGTGAGAGACAAATTGGCAGTGTGGATATCCAGGAGAACACAA


ATAGGTCTTTGTTTGTACCCCAGACCTTTAGAAATCATGGAGTCTGGGTGCTCCTAGATTATTCTGTAGCCACAGGAGATTTGACCG


GCTTGTGCCAGACAGTCTCTATAATTGAATTCTTGGTGCCCACTGCATACCACCTCCTTCCCAGCATCCTCGGCTCCATTTGGTTTT


GTGTCTGCCATGTCACGACTGGACCACGTTTTCCCTTCTCTGGCTTCTTCACGTTTCTTGGAGGACGGCTTGGGAGCAGCCCCTTGG


CACACAGTGGTGTGCTCTGGGTGCTAGCC)CGGCAGGACATCCGCTACAGGAAGAACTGCTATCCCTCTGCCCCCTCACCCTTGGCT


GGTGGCCGTGCCCCCTTCCAGCTGCCAGGGGGTTCAGTTCCTTGCCTTTGTCTATAGGGTGGGGGAGGGGGGAGCACTACCTCCTTG


GCTCCCCATCTTCATTTGGAAGCCAAAGTCGCTCCTCCGACGGGGCACTGTGTTGCCTAGGCATGCAGGTGGTCCATGGGAAGATTG


GAAAGGGTTGCTGCTACTTGGTGTGTGGTGPACTGGCAGGGGAGTGTGGAGTGCCATTGCTTGTGGCTATGAGGGAGCTGTAGAAAG


AGCATCTATAGTTAGACCCTGTGCTGAAGAGCCCCTTTCCACGTAGTCTGTGTAGACCCTGGAGACTATAGAAGCCGCTTCTCTCTG


GATTAACTGTCGCAGCAGCCTCCTCTGGAGGATCATTGGCAAGTGTTGTAAAAGCCTCAGCTTCCTCCTGGTGTAAGTGAAGAAGAG


CTTATCTGCCTTCTTGCCTGCTTATGAAATAACTAGAGGGTCACCCGTTCATCTACATAGTCAGTGTCCTACACCTATCTCTGCTTT


TTTTTTGAAAAACTTGTTACCTTGGAAACAGTGCCCCAGCTTAGAAATTACATAAGGCTAGCTGTCTGGTTTTTTGTTTTTTTTTTT


TTTTTTTTGTATTTTGTATTTTGTATTTTTGTTTTTCTCCCCACAGGAAAAGCAGAGGAACAGGGGAAAGGTTATAGATTTTTTTTT


TCTAAAATATCTTCAGGGGTTAGGAGAACAGGGTGGGGAAGGAAAGGGAGAGATGTGTTCTTCTGGTAACATTTGTAGAATACTCAG


CTGAAGTTCTTTAAAGATACGATTTGGTTGGTAGCCAGTGAGCTCTAGCGGCCCATCTTCTCAGCGGAGGACTTTGCCTTCACATCT


GGATGGAATGAGGACACTTCCATGGTTCTGAAAGTCCTTTGCTCCACGAGTGAGGAGCCTGGCATCCAGAGGTGACATGAGTCACAC


AAGGGCATTCAGAATCTTCTGTAGAATTCACCATTCCCGACTCAGATGCTGTCAAGGCCGAGGGAGGGAGGTGTCTGAGAATATTAT


TGTCTGGAAGTCAAGTAGCAGTCAGCTTGCTTGCTTGGTGAAGAAACAGAGCAACCTGGCCTCACGTTTTCAGTCCCTTGTTCCTGG


CAATAAAAGGATGCTGTGCACGGAAATTGTCAAAAACATGCCTTCCCATCCAAAGCCTGATCGGTCCTCTTGGTAACTGTTTTGTCT


TTTTGGTTTTAGTTTTGTGAAGTTCCTCTCACTTTGCTTTTCTATAGTGATCTACCTACGACATGAGGAAACACACTGACTTTTATA


TGTTTTCTTCTTAAAAATGTATATGGAACATGTTAGCCCAAGGGAAGTACAGAAACTTAGAAAGAGTTTTGAGGAAAGCGGTAAGTT


TTAAACTCAGCACAGTGTTCCAGTTGTGCCGTTGAGGCAAATGTTTGGTGTAGTAGTGGGGACTGTGTAGAATTTCTTTCTGAATGT


TGTTGTGTATTCATCCTGCATTGGCAAATATATCTTCGTACCCCCCAGCTCCAGCATAGGCAGGCAGTGTATTTATTTATTCGGTGA


TACAGCAGTTGCTTAGCTGACCTTAAGTGCTTGCCGTACACTGTGCTGGGAAGCATAGTTGGATACTGTTCATAACCTCTGCTAAAG


CTTGGACATTCATGTTGAATTGGTTTCCGGACATITTTAGATAAAAAGAGCGGTGTGTGTGTGTGTTTTGGGTGTGGTAGGTGCATG


TGTGGGTGTATTTATGTGTGTATGTGTGTGTATATGTGTGTGGTGTGGGTGTATATGTGTGTGTGGTATGTGTGGTGTATAGGTGAT


GTGTGTGTATATATGTGTGTGTAGTGGGTGTATATGTGTGTGTGGTATGTGTGGTGTATAGGTGATGTGTGTGTATATATGTGTGTG


TATATGTGTGTGGTGTGATGTGTATGTGTGTTGGGTGTGATAGATGTATGTGTGGGAGTATATATGTGTGTGGTGTGGGTGTATATA


TATGTGTGTATGTGTGTGTATGTGTGTGGTGTGGGTGTATATGTGTGTGAGTATATGTGTGTGTGGTGTGGGTGTATATATGTGGTG


TGTGTGTGTGTGTGTGTGTGTATGCAAGTGTGGTGTATGTATTGCTGGAAGTGGCCATGTGTGTGTGAATGCCAGGTGGCTTCCTCC


ATCITTGTTCACCATTTGTGCAGACAAGGTCTCTGATGGCACCTAAGCTCACAGTTAGACTCACCAGCCAGTGAACCCCTGAATCTT


CCTGTCTCCCCCTCCCAGCATGGGGATTATAAGAGCACTGCACCTCGACAACTAGACTTTTTATGTGAATGCTTGGAACCTGAACTT


AGGTCCTCCAGCACTCATGATATTCACTGCACTATCTCACAGCCTCTGAGGGGAACATTTTTGTTGCTTGCATATATTGGGAATGAT


TGGTTTTTTCATACAGTGGTATTAGTCCTACTGTTCTTACAGTAAGAATAATTCCTGACATCTCCCTGCTGTGTCTGAGGGTAGGGT


AGGGATCCGTGAACTTCGGCATAGGGGTAGTTTCTGGACAGTGGGACGAGGAGCTGGGCAGAGTGGAGCCGAGTCATGGAATGTGCG


AGCCAGTACCTCGTGCTGGTACTGGCTGCACAGTAGAGAGGGTTGGAGGAGCAGTGACCTGGGAGTAGAAGATTCTGCAGATGCGTG


GCTGGAACTTCCTAGCAGGTATTCAGTGTACAGTTTTGCCATTATTCCCTAGGTCCCATGTGAGAGTGATCTAGTGGTGGTCTCTCT


CGTCACCAGTGGAGATGAGCTCCTGGACACTCCTATAACCCAGCTATGAGCTAGTATCTCACCCTGGTCTCCAGGCTGCAGGAAAGC


CTGTTGGCCAGCTCTTGCCTCTACCCACCATGACCTCTCTCTCTCTCTAAGGCAAATCACTGGCTCCACAGAGTATTTAGAAATATT


TCTATTTTTTTTAAAGGTTTTTAAGAAGGTTGAACTGAAGACAAAGGAATGGTCTAATGAACAGCAAAATATAATGACTCAGTTATA


AAATGTCAAGATGATAATACAATAAATAAAAAGTTAATCCATTTTGGACTCCACTGTGTTGCTCTTGTTTGTGGAGAACTGTCATTG


TGGCAGAGTAATTAAAACCCTACAGAGGGTTAGGAGTCAAGAAGGAGAGAAAAGAGGCAAGGGGGAGCTGCCTAGAAGACAGGAGAA


CTTTCTAGAGTGCTGAGGCATGCAGTTCCGAGAGGTGATATTTTGCTTCTCTGACTGCACATTTCACATCTATGAGGGCTAAGCACC


TGGGTTACACAGGTGACCCGAATTGGAAGTGATCACGATCTGAGATGGACCTGCGCTTGCTCTGTAAATCGCATGGTTGCCAACTAA


GCCACGAGCCCTGCCTCACACTGCTTTACTGCATTTTCAAAAGACTTTCTTATTTCTAGACCTTACTAGGTCTTGCTCACTGTTTGT


GCTAACACACGCCAAAGAAGATGAAAGCCAGAGCGGTATGTTACCCTCTGCCGTTGAGCTCCTGTTTGTGTCGTAGCCTGGTCAGTC


TTCAAGTGCCAACAAGTCGTTCTGGTTCATTTTTCTTGCCCTTCTTTATTGGCTCTGAGGTTTTCAGTGGTCAGCCTGTGCTTATAG


CTTCAAGTCATTAACTTTGATCAAAACAGGAGGGATTTGAGAAGTCAAAGGACAGAGGAAAAAATCCAGAGCTAGCCAGAATCTTTG


GTTTTCTATAGAAACGAGTGAGAGAGAGGGAACGTTCCAGGAATCAATATACTGGCTCTGCCCTTCCCACCCTGGCCTAGTTAAAGT


GGCTTCTTCCTATACCATTGCACGTCTGGCTGGCATTGGGAATATTCTTAGGTTGTCAGGTTCCATTCTGGAATTAAAAATGTATAA


TTATCTTTTTAAACATTTTTGTGTATTAGCTTTAAAATCAAATAACATAAATGAATCAGATGTACTTTTTGACTGTCTTTTGGTTTC


TTGCTGCCAAGGACACCCCACCGTGGCATTTGAGTCCAGCTGGCAGCGATACTAGACTCAGCACAGGTCACCTTTGGGTTGCTCTGC


TATTTCAGTTCTGTTGGAAGTGTTGTGCACGGGGGGCCCTTGCCTGCCTGGGACGTGTGAGCCTGAGGTGAGTTTGCCCACACAGCC


TTTCTCTGGTTTGCAAGAGAGTCACAGGGGTCAGCTGGCATCTGCAGTCTAGCTGAGGTGATTGTCTATGTGAATGTTTTCTCAGAA


CCAGATAAACCTGTGTCACTTGCAACACTACCACTACACACATCGGCACTAGCTTGGTGACAGTGGATGGTTCTACTCTAAAATGGT


TTTTCAGAGACTCGACTGTGTGAAGCCTACATAGAAATGAGTATGATTGTAATTATGATGAGTAAGAGCTTATTTTCTTTTAAAGAA


GGTAATTGAAAATTTAATTTCAACTGACATGTCTAATCTCTTCTATAAACAGATAGAGTTTTATTTTGAGAAAGGAGCCTGGATAGT


CCAGGGTGTCCTTGGCCTCGTTAATGAGACAGAGATGACTGTGACATGTTTGTTAGCCCTTGTGTGAGTGGTGATATGACTGGAGAG


CACTTCCACATGCAGCTTCTATGGCATTGGACAGGTACTGGGGAAGCACTCTACCAACCGAGCTATAGTCCTGGCCCTTTAAAAGTC


TGCAGGAGTTTGTTACATGGCCCAAGCTGGCCTAGAACACACTATTCTGCCTCTGCCTCTCAAATGCTGATATTACAGCTATGCTTG


CTACCGTGGCTAGAAATACGAAAGTGGCCGGGCGTGGTGGCGCACGCCTTTAATCCCAGCACTTAGGAGGCAGAGGCAGGCGGATTT


CTGAGTTCGAGGCCAGCCTGGTCTACAAAGTGAGTTCCAGGACAGCCAGGGCTATACAGAGAAACCCTGTCTTAAAAAAAACAAAAC


AACAACAAAAGAAATACGAAGAAAGTGTATTCATTCCGTAGACAAATCACTAATAAAAGAATCTCACAGTGTCCTACCTAGCCAACT


GTCACATACTGTGGATACTCAGATCTTCGTAAAGGTGGGTGGGAACTTTCATTCATTTTGATTGGGGTTTGTCGAGTAACACGGACC


TGCAGAGGATGTCGTCATTGAGTAACACGGACCTGCAGAGAGTATTGTCATCATTTTCTGATTTGTAGATGGCCGCCCTTTACACTG


CTGATGAAGCTCAGGGTTGACTAAACACACCTCCGCAGCCTTTGCCTTCTACATAGGCCTGAACTCGAGAGAAAGCTGGGCGTAGAG


CAGCCCCTGAGAAGCCTAATAGGGAGAGAGCTGGGCGTGAAAGCCGCCATGCTGAACTACCCCACATAACACAGTCTTCTTGGCTGC


CTTGTTTTCTTAATGGTTTTAGTGGGGAAACCAATAACATGTTCGTTTGAAGAAGCAGTTAAAAAATAATCAAACTTAACTGAAAAC


GGAGCCCCCGCCTTTGTTAAACATCCGTTTATTTGGCTTGCTTTCTGTCACGTCTCTCTGAAAACAGAGCCATGAGTCCTTTCTGTT


TAACTGATCTGCTCGGTGCTAACCCAGTGCCCTTCATAGCTCAAGTCTAGGGTCTGAGGTCTCTGTGAAAGTGCTGTGCCTACACCA


GGTTTGCCATGGAGGCCGGGAACTGGTTTTCGTGTGCAGTGACGTTGTGTTGGTCTTGAAGCACGGGAAGAGGGCTTGAGGATGGTG


GAAGAGGTCAGAGCGAAGTAAGGGAATCGCATAGCCAGCTTCGGGCCTGGAGCAGGGGCAGGGCGTGGATGCTGGCGATTGAGAGTT


GGGCATGGGGGCGGGGTGCAGGTGCCAGTGTAGAGGAGTCTCTCCTCCCTGCCCAAGCCTCATTGGTCTTTATTTCCTTGCCATCAA


TAATGACATCAGGGCTGGAACAGAGGATACATTCAGTGTTTCGGATGCACCCACAAGTGAGAAGCTGCCATTGCCACCTGCCTGAAG


CTTCCAGCCGGCATATGGAGGGTCCCAGCCGGCATATGGAGGGTCCGTGCACTTCTTCAGGAAGCATCAGACCTTTGGCTCAGCAGA


AGGGATTCCTGAGCAGGTGTCTGGGTGGGAGGTGAGGCAGGAAGGCAGGCTGATGTTACTACCTAACGGAGAACTGCGGCGTCTTTT


TCCCTTTCTTCTGTAGTCAAGTGGCTCCTAGTTCAAGGGCAAAAGTTGGGAACAGTGTTCAGCTATGCGGGCCGGCCATACTCTGTT


CTTCCTTGGAAGAGACAGCCGCAGATGGCCCATCCCTTTGCTGTAGCTCACCAGTCTTATCTGCTCAGCATTAGGCTCAGGGAACTT


TCCAAGCACAAAGGAACCATTCTCGGGTTCCAAGACTGGAAAGGCCTTGGAACTGCGTTTTTAAAATTTCACTTTATTTATTATTTA


TTGTTTTAAACATCTTATCCCTGAAGCCCAGCACAGGGGCTGGCAGACTATAAATGCTAATAGAAAAAGATAAAAGAAAAAAAAAAA


GGCAGTTCAGGCCTGGTTTCTTGGAACAGAGCTGAGAGGAGAATTCGCCTTAGACTAGATGAGCCGAGAGTCACTTTAGGATTATTT


CCTCTTATCGAAGTGTAAGTATTTTGGGGGTGGGATGTGAGTGAACTCCCTCACGGCTGTCGGAGATAAAGTGTGGGGGTTTCTGCT


CACGTTGCAAGTTCCCGTCTCAGGAGGAGGTTTTGTGAGACTTGGTCTGCCTCCTGACCGTACAACTTTGCATAATTGATTAACCAA


GTATCGCTGTTTGCATTCCCTTCCTAAAATAAATTCCACTTTTTAATTAACTCTCCAGAATTAATAAGTGCCAAAAACGCAGGATGT


GTGTTGAATCTTGTGATTCGATGTGATGAAGGCAGCTCCCAGGGAAAACAAGTCTAACAAATGATTTTGAGTCCGTGAAGGTATTCT


TAGTTCCTGAGCATGGTAAACAGCTCTCTAAAAGCAGTTAATGCCCGCTGGCCTTCGTGTGGGCCAAGCGCCATGCTATGCCTAGGG


CATCTCGGCTACTCCCTTTGGTTAGCTCTTTATGAACCCAGTACCTAGCTGAGTGGCAGAGCCTTTGCCTATAACCGAGGGATGGGT


TGGGATAGGGAATTGGGTTCCATCCGCAGAACCTCAGGAACACACCTGCCACATGAACTGGGTGTGGCGGCGCACACCTGTGAACCC


AGTTCGTGGGAGCGGAAGCAGGAAGATTGAAAGCAGAGGTTCAAGGCTATCCTCAGCCAGCCTGGATTATACAACTCTAAGATTAGC


TTTCTGATGATCCGTATCTCCACAGAGAAGCCGTTTGCCAAATTGACGCTGCCAGTGTCTAGCAGCCCTGAATTTGATCTGCAAGGC


CAGACTCTCAAAACAGTGTTCCTCCAAATCAGGCCACTCCCCTCCGCTACAACCCCCTATTAGCCCCTTTGTATCTTCAGGTTGTCT


TTACTGCAGCATCTTCTCTCAGGTCCACTGTGGACTGTCTGGTCAGACGTGCTAAACATGGTGAGTTTGTTGGTATTGGAAATGTCC


CAAATACATGGCTCCTAATATAGAACCCAACTTAAGGAAGTCTTTAGGCAAATGACACCACTTGTATAATGGTAGGTCACAGCCCTC


TAATGACTTGGAGTCAATGCTGGGTCATTCTGTGCCTGTGTGTTTCACAGAAGCAGAAACCTAGAGCCGCAAAACCAAGCAGGGAGG


TTACTGGAGCCTCACGGGGAGAACACAGCTAAGGATTCTGGTGGGCAGGCTCTTGGGAAACAGGAAGAGCGGAAAACATTGCAAATG


AGTAGCACCCCCATAGCTTCCAAAGGAGAGGTGAAGTCTTCACCGGAGTCCAAAACTGGCGATCCGGCGGCTGTCCTCTGAATGAGC


AGAAATCCGAAAAAGGCAGCCGGAGTATGGTTTTTCAAATTGGACTTTAATTTTTTACTTTCAAATAGACTTTAAAGCAGTGGTTTT


CTATAGCTTTATGAATGAGGAGGATCCAGTGAAGTGTCGTATGTGAATAAACAGGTGTTAGACATGACTGTGTGGCCATCATGGATG


GCCTACTGTGATTAATGCACGCCTAGGTTATTTTCATTAAAAAGTAAAATGTGTTCGTTCCTATTGTAACAAGAAAGGCTAAGTATT


AGGGGCAGAGGAAGGACGGAGTGCAGGTAACCGACGACGTGAGTTATAAAAGAGGATTCAAAGCTAATTGCTTTGCTAGTCCTAACC


CTGTGGTAGATTCTCTTCTTTTCAGTGGTAAGTGTATGACATGGATTTGATGCTGAAGTCTTAATAACACTGGAAAAGTCGATCGTG


CCTATAAGTCTTGAGACAAAGAAGAAAGCAATACTTTCTGATGTTTTTTTAAATCCTCTTGTAAATGATGTGAGCATAAAGAACGTG


ATAAAACACTGCAGCCCTTCTGAGACGGAGAGGAAATACAATAAGCTGATACTTGAATGTAGCACTGAGTATCAGAGAGTTGTAGTT


TCTGTGGAAACAGAAAAAGTTTTCAGAATATCGTGTAGCTGTGTAATATGTTGATTATTTAAGGGAGGGGGAGCCTCGAAGGAGATT


TTTATTTAGCTTTAATGGTTTTCTTTATTTTCCTTTCGTTTTGTTTTTGTTTTGTTTTTATGAGAGATTGTTATTGTTGTGAATTAA


GAAAGAAAACTGGTGAGATATTATTCCTGATCCTCTGGACCAATCTAAGGAAACAAAGGAATTACTGCCCCACCCCCACCCCCTTGT


GGTCCTGACTGGCCAGGACAGACCTTAGCATGAGAAAACAAGTAGGAGAACTAGAGACCTGGTCCCCAAGGCTCTCACACTGCCCCC


ACCTGCATCTGTCGAGGGCTCAGGACTGAGGGATTAGTGGTGATAGTGTCTCCTTGGACGGACTGACAGTGACGAGCTGTTTCTTCT


CTAAAAATGAACTCCCCAGCCAGCTGTGGATATACACTCAAGTTTTTAGTGACATTTTAGAAAATCTGCATATATGTCCAAGAAAGG


CCTGTGAAATGTTTGAGAGTTTAAGATTATTCTGAAGCTTTATAAAAGTGTTTTCTGTGATTTTTGTTTTCTGGATATTTGTATCCC


TGCCTGTGTGCTATCATGGTTAATTTGCACTGTATCACTATGCCTGAGAAGCCTCTATTAGTGACTGTCCCTGTCATCCTGTGAGCT


GTGTCTGTCACCGCTCTGTGGACAGGAGTGTTCCCAGGAGACCCGGTCTGAAATGCTTGGACTTAGGAAGGCCCCTGGGAGAGAGTT


CAAGATCTATGAAGGATGACTATTTAAGACTGGCCAGGAATGAGCCCAACCCATTCACTGCACAGAGAGACCATTGCTGCTGGTGCA


AAGAGGGGAATCCCCTGTAGCAGAACTCAGCTCCGGAAGGTGGAGTCTGCCCATTGTTAACTGTTGATACCTCAGGATGGCCGTGGT


AGACGTCAGTTCAACTTCAGTGAGGAGGCAGAAATACAGGCTACACCTTTAAAGGTTTGAGAGGTTGGCTGTTCAGGGTGACAAGGA


TTACCTTAGGGATTAATGAATTAAGAGAGGTGGAAAGCTAAAGCCGTCCTTTCTGCACCATTCAGTTCCATTGGACGCATACTTTCC


CAGGCTGAGTGGACCATTTGCCTTGGCGGAAACTCACGGCCTTTGAAAATGATGACATCGGGCCAGTTCTGTAACTATGATTTATGC


TCGAGTCTGTACACCGTGGGTCAGATTAATTCAGTGCTGCCCTAAGGGACCCAGTTGTTGAAGAACTGCTATCTCCACACCCAGAAG


CTGTGTTAATGGTCCACTGATGCCCCGAGAGCCCGTGTTCTTAAGGTACCAAAGTGCTTTTGTGTTTGCTGCAGGATTATTTTAAGT


CACAGGCGCACTTTGGAGATGATCACCACTCACATTTTGCTTAAAAGAGTAAGACAAGCCAGCCTGAGGTCCAGAATGGTCGGTACT


GATGCTGCACCTTGGTCGTTGGTGGGAGAGATGAGATCAGTATTTAACAGTTGGAGAATTCTCAGTCTTGTCAATCAAAGCATATTA


CATGGGTGTTTCCACACCATTTGAAGTGATGATTTAAATTCATTTCTAGTTGTGAGCTGTGCGAGAGTGGACGCCCTGGGCTTTGGA


AGCTGCTCTTTCTCCACGTGGCCTTTTAAGCTGCGGTAGATGTTGGTGAGGAAAGGCGTTCCTGTGATGTTTTGTCTTTTCTTTTTT


TCAACAAGTGGTTCCCCCCACCCCTGCTCCCACGAGAGGCAGGGTTTCTCTGTGTAGCCCTGGCTGTCCTGGAACTCCCTCTGTAGA


CCAGGCTGGCCTCGAACTCAGAAATCCACCTGCCTCTGCCTCCCAAGTGCTGGGATTAAAGGCGTGCGCCACCGCTGCCTTTCGAGA


TGTATTTTCTTAAGGGTGTTTTTCCTTGTACTTCCAGGTCAGACCTTACGAGGACAAACTCAATTGTGGATTTAATGTCTGTGTACT


CCTCAGCGTCTCCAGGTCCCCTTCAGAACTTTGTAGAAATTGTTAGTGTTGTTTGGGTTGATAGCCATGGCCAACCCAGGGACAGAA


CAAAGGAGACATCTCTAATGAAAGGAAAGAGGGTAGAGGCGCATTGGTGTGTATCCTCCGAGACTCCTTCCCTCACAGGAAAGAATG


TGTATCCTTTCCTCTGGGGGAAGGGTGGGTGACTGGATCAGCCCAGACAAAAACAACATATGGTTAGTTTTCGGAGGACTTGTAGAC


AGATGGCAACCTATAGGCTAATTATGCAGTGGGCGACATTCTTTAAACAAATCACTGCTTTTGTGGCATGGTTCTTACTCACAAGGT


GACAATCTGAACTGTTTATTGTCACACCAGGTAAACATGTGCCAGGTGAATGAGGGAAGGTGCTACCCGAGGGAACATAGTTATATT


GAGTTTCCATTTGCATCTTGATCTTCCAGGCCAAAAGAACAAAGAACGGCAGGAAATTCACAGAATAAGACAAACCTTCAGGTCAGG


GTAGGGTGTAGCCCAGTGGCACACTGGAGGGCTAGTGTGTGTAAGGCTCTGGATCCAGCCCCCTAGCAGCTAACAGATCACCAAAGT


CGTCATGCTAGGGGCTGTTGCCTTGGGGGAGATGACCTGTGTCAACCTTCTTGTACTCACTCGGAATGCGATGTTTCCCGTGTCTCT


GCCATCAGAAAGCAGGTTGTCAGAGCACTGTGTCAGGCTTTGGATGAGCAAGGTGGGCAGGTCACCCCTCAGAGTTCTGCCCTGGCT


CCTTCCTGTCCAATCCTGTGTCAGCATGTTCAAGGTCGCCCTCACCCACTCCTCCTTCATGCTTCCTCTTTCTCATTTAGATTTTTC


TTCACTGGCCTTTTAACTATCTGCAGTACAGGTTTTGTTTTAAGTTTCATTATTGAGTGTCTCCTTCCACGAGGGTTGCTTCACAAG


GACGAGGGGCCCAGTCTGTTCTCTGCCTGTGACAGGGCTTTGTGTTTGCAGAGGTAAGGGAGGGGTCCATTAAAACTGCAACCCAAC


CTTTTTCCTCCCCAGTTTGTAGGCATGCCACGTGGGCCCGGTGTGCATTGGTCATGGGCTCTGATGGCTGGTCCCACCCTGTCCTTG


AGAACAGATTAGGGGCTCATTGTAATGTTTGCAATGTCTCCAGTCCCACTCTCTGATGTAGACTTGTTTTTGAACTGAATGAGCCAA


CTGACTCAGCTGAGGAGATGGTCAGGAGCCAGGCTTGTTCCTGGCCAGCAGCCTGAATGGTGGGTGGTTTCCTGTCCATCCTGTTAC


ATAGGTTCAACCTAAGGGGTGTGGCCATGGTTTAAATTTAGGTCCGATTGGTGTTCAGCTTGGCTCTACCAGGAGTGCTTTACACAC


AGGATTCCTGTTTCAGTGTTAACTTTCTTACATCTCACAAAGCCACAGTACATGTATGTTTTTACTTATATGATTGAGAAACTATGA


AAAGGTGCTACTAATAGCTTAATAGTGCTTTTAGAATAGTTTTACTAATATTATAAATTTGAGAAATAGCCCAGCACAGTGGGTTGG


AGTCCTTCTCTGGAGTCGTATTTGCCAGCCCTACAAGGGCTCTGATGGCCCATGGCCACCTCTAAGACACTGTGACCTCCGTCTCTG


GAAAGCTCCCCTCTTCATGCAATATATGCTATCTCATCTCTCCCCTGGTTAGCTGGCTAACTTAGATTTTGTTGGGACTGTCTGGCC


AGATTGCTTTTTATACTTAAGTTTGTTGCTTTGTAAAGAGCCCCTGGTTTGAAAGTAGTCATCAGACTAGAATCTGTTAGAATTAGG


GATGTGGGCAGATGCATTCTGACCGAGCTGCAGGAACTTTCTATATGCTGGTTGGTTGGTTTAGATGGTTTGGTTCCAGGCCTTGAG


AGGCCAGGTCCTTGGTCTTCTCAAGGATTCATTAGGTGAGGAAGTGCATGTATCCCTCACAGGGAAGTTGGGCTCAGTTCTTAGGAG


ATGGGGTATGACTGTGACAAGGTGGGAGGTCTATACAAGAGCAAAGGTGCCCTGGTGAGAGGTCTTAAACCTGATTGAGGGCACAGG


TAGTAGCACTGAGGACTCACAGAAAGATTAGTTCCTTGGTGCTGTTCCCTGTATCCTCATCTCTGATTGGGTATTTTGTTGTTGTTG


GTTCATTGTATTTAGTAGATTGGGTTAATTCAAAAAGGGAAGGTAGAAGAGCAAAAAGACTTTTTTTTGTATTCATTTTTAAAAAGG


AATACACAGTCAAGTTCTTACTACAAAATAAATGATCCTTTTGAGGGGAGTCAGAGGGCCTTGTAAAGTGGATACTTTGTAATATAT


ACAGAATAAAGTGGATACTTTGTAATATATTTATATATTATATATGGAATAAAGTAGATACTTTGTAATATATATGGAATAATGTGG


ATGCTTTGTAATATATTTATATATTATATGTGGAATAAAGTGGATACTTTGTAATACATATGGAATAAAGTAGATGCTTTGTAATAT


ATATAGAATACAATAAAGTAAGAACCATCTTTAGCCAAATTCCCATAGTAACTATAGTAAGAAAATGTTTCAGGCAGACCCATGGTA


ACCCTCAGTATGGACCACTGAAGTGTGTGCTCAACAAGCTGCACACCAGAGGCCAAGGGTCTGAGGAGCATAGTTGAAATATTTTCT


CCCAATCTTCAAGTCTTCTGCGGAGACAGCAGGGAAATTATACTGAGATAAGTGGTGAATAAGGGTGAGAGAGAAAGATGTAGGCTA


GACATAGCTCTCCAATCAAGACTGTGTTTCTACTTCTTGCTCTTTGTCTGCATTTTTAAAATACCCACCATGCAGTGCTCTCAGCTC


TATTTTCCCTACTGTTTTTCCTACCCAGTGATTGAGGGGAGATTATGCTCTATCAAGAATTCACAGTTTTGGCAGTCTCATGTCGTC


TCTGTCATCTGTTCACTTGACCTCATTCTTGCAAAGGGCATTTGGGTGTGTCCTGGAATTGTCTTAAACTTTCAGTGAATAGAGAAC


TCAGATCACATGGATTGCAGTTTGGAAATCTGCTGTCAGCTGATGAAGCTGAATGAATGTGTGGTCTCGGTGTGGGCACGGCCCTAG


GGTGTGAGTTGTGGCCGAGTATTAGCTGTGTGCCTGGCATGTGCTGTCACAGGTCTGACATGTGCCTCTGTTTCATTTCTGGGAGCT


TCTCCACGTGCTGCCTTCACTGAGCAAATGAGATTAGATTTTTCTAGATCTCTTGGCATGTCTTTGTCACCACCTTTATGACTAAAG


GACATAAAGTTAAGATATGATTGATGTCTAATTGAAAAATAGCCACTTCTGTGGATTGAAACCTTCAAAGAAGCGGACTGGAGAGAT


GGCTCAGAGGTTAGGAATGCTCATTGTTCTTGCAGAGGACTGGGGTTTGATCTCCAGAACACCTACATGGTAGCTCACACTACTCTT


ACCTCCAGTTTCAGAGAATTCAAAACCCTCTTCTGACATCTGCATCTGGTACAGGTACCCTCTAGAATGCATTGATATAATCAGCCA


GTCAATCAATAGCCAGTCTAATCATAGCCAGTCAATCATCAATCAGTCAGTAGTCTCGGTGCTCACTGTTCAATCATTAGGACTCAA


GTTGGATTCCTCAGGAACCCAGGTAGCATGCCTCCTTAATCCCATCATTCCTAGAGAGACGGGGGGGGGGGGGCATGGACAGAATCC


CCAGAAGTACTCAGGCTCGCTCACATGGCATACACTAGACAAGAGACCCTGTCTCAAATGAGACCAAAGGTAAGGACTAACTCTGGA


GGTTGTCCTCTGGCCTCCCCACATGCTCGGTGACATGTGCACACCAGTATTCATGCACATAAACATGTACGCACATAGATACATGAC


AGGTGTCTCACATACACCTCAAAAAGATGAAAAGAAAAAAAAAGTCATTGGCATGAAGGAAAGGCGTTGCTGAATGACAGAATGCCC


TGTTTTCCACCAGCCGTTGGAGTAGACAGCTACCGAGGGTAGCCTCTCAAACAGACTCTTTGCAAATCAACTCCAAGTTCAGCAAAG


CTTCCCCGGTGGCATAGACAGGAACTTGCTCTGAGTTTCGGAGACCCTGAATCTCTCAGGGTCATTTTTGTATCTCTTACCCCCTGT


GATGGTTAATATTGATGGTCAAAGTGCTAGGATCTGGTGGCACATCTACAAGGAATTTTTTTTTTTTAAGATTAGGTTTGAGGTGGG


GAGAATGACCATAAATGTGGACAGAACTGTTTTATGGGCCAGGGTCCTAGACTGAATCAAAAGAAGAAAAGCAACTGAGCAGCAGTG


TCTTCCTGCTCTGTTTCCTGGAGGTGTATGCCCCACGACCAGCTGCCTCACTTCCTCCTACTGCCCTATCATCCTCGCCATGAGGGA


TGGTGCCCTCTATGAGCCAAAAAAATCCAGGTATTTTTTCACAGCAACAAGAAATGAAGTGAATACACTTCCCTAAGGCTTCTCTTG


TGTTTTCCTCTTTTTCCTCTATTCCTACCATTACTGCTTGTCCTTGGTACCTTGTGCCCCTCAGCCGTCTAAGCTCTACTCTGAACA


TAAAAAGGGCTGATTTCTTCATCCTGATAACCCCCTCAGGACATGGCTGCATAAAACCAGATCCTAGCCTGACTCAGGCCAGGCTCA


TGCTGTCTCTAGTTCCCTTCTGTGGCCTGGGAGTCTTGGTGCAGGAATGACAAATCAGTACACAGTCTCCTACTGTTTGCCAGGTCC


CTGGAGGAGCCAGATCAAAGTCAGATGCTCTGTTGGCCCCTGAGAATAAAGATAGAGAAGTCCAGGGTCAGTAGGCATCCAGCTTAA


GTCCACAGTGTCTCCTTCATGACCAGGAGGCCTCCACTGTGGCACTGTGCAAGTTGGCTTTGGCTGCTGTCAGTGTCCACTGTGGAT


CCTGATGTTGCCCATGACCCTTTCTCTAGGAATGCTAGTCTGAGCGTAAGGCCATTGTTCTTCTCTGTCTCTCTTTGCTTAAGAAAG


GCCTCCGGGCAGTGGTGGCGCACGCCTTTAATCCCAGCACATGGGAGGCAGAGGCAGGTGAATTTCTGAGTTCCAGGCCAGCCTGGT


CTACAGAGTTAGTTCCAGGACAGCCAGGGCTACACAGAGAAACCCTGTCTCGAAACAAACAAACAAACAAACAAACAAAAAACCAAA


AACAAAAAAAAAAAAGAAAGAAAGAAAGAAAGAAAGGCTAAGCCCCTTTTTTACCCTTAGACTTAGAACTTTTAACTTGATAGGTGT


GTTGAGAGGGGTTGTTGCACATCTGGTTCTCAGAGTTCATCTCTGAGAGCAGAAGTCTTTTTTTTTTTTTTTCTCATTTCAAAACCC


CACTGTGCCCTGTTCCCCTATCTTATTTCCTTAAAACCTGTTAAGGCCATAATTTTAGAGATGGCATTCCATTTTTCTTTGCCTGAT


TTTCTTGGTCAGCCTTTCAGAGTCAGCCAGCCTTTTTTTTTTTTCTTCCCTCTACTCTTCTCCATTTTAGAAAGGGGCCTGGTCCCA


TCACAATCTACCATCTGTCTCTGATGAGGTGTCCTGAGCTCTAAAAACCCATCTGGACACTTTCCACCGTCCTTAAAGGTACAGGAT


GCTCCCGGGTCACAGCTTTATCCTGAAGTCTGAGCACTTTGTACGCGCTTCATTTAGTCGTCTTAGAGAGGGACATTGAAATCTGAG


GCTCCTTGGATTTTCAGGTTAGGGTTATTCAGTCCATAAAGTCTATGCAAGAATTCTGAAATCAAAAGAATTTCCGAGTTCAAGCTA


CCACTGCTCTCAACTGCTTCATATGCAACGCTGTGTTGTTAGCCCTGCTTTACAGGTGAGGATGGTGAAGCCCAGAATCTCAGTCTG


GTTAGAACCGCCTGGGTACCCTTTTCCTCTGCTCTGAATGCCCAGTGCCCTCTAGTGCACCCAGCTACACTCCTGGTTGACCTGCCT


GTCCTCTTGGTGTGAGCCCAGCCCGTTTCTGCATCTCTGTCTCTCTGCCCCAGGCGGTACTTTCCTTCACGCCCTCTCCCTGCCTGT


CATCTCTGAACTCCCGAGGTACTCAAGGATATTCTAGAAGCAGACCCATCTGTTGTGACCCAAGAGCCATGCTGTGTTGCTTGGCAC


AAGTTGGCTAAACTCTTTGGCTCCCTGCAAAACAGGCTTCATAAGGTTCCTAGAGGATTGTATAAAAAAATTCTTTGTAAACAGATC


CCCCTCCCCTGCCATTCTCAACACATCAGCTATTATTCAGACTTCTTACTACGTCTTACAGCAGCAGGATGGATATATAGGAAGGTG


TTTCTACCAGCATGGATGCTCTGAGAAATGAATAGTTACGTGAGTTCACTGTTCAAACACAGTGCACTTACGTAAACCAAGATGGCC


CCATTGCCACTAGACGGTGGGCCCCTCAGACTACTTTTGTATATTTGGCCAGCTGACAGAAAGATTATTATATAATACATGACTCCT


CTTTAATATTGTGACTCACAGGCTGTGAGCACGCCCGGTTTTGTCAGGACATTTTCTTCTAGTTTGTGTGTGTGTGTATGTGTGTGT


TTGCTATAAACAATGCTGGTTTGTGTTGTTTAATTGATGGATGACTAGCCACTGTCAGAGGCCACCCACAGTGACCTGAATGGCACT


AAGCCCCTTGANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCAAACTCACCTCAGGCTCACACGTCCCAGGCAGGCAAGGGCCC


CCCGTGCACAACACACACACACACACACACACACACACACACACGCACGCTCACACGCACACGTGCACACTCATATGAAGCTAGAAT


TTGCATATGGGAACATGTTTTTGTCTTTCTGAGCCTGGGTTACAGTATTTAATATAGTAATTTCCAGTTCCATCTATTTTCTCTTTC


ACATCCACAATTTCTTCTTCCCGGTGATTGCATAAATTCCATTGTTTCTACGCTCCATGTTGTCATTTTCCACTCTTCAGTGGATGG


ACACCCGGGCAGTGGTGGCTCCTCTTCATTCTCCTGCACCCTCATGGCCCTAGCCAGTGATGGAGACTCAGCTGGTTCTCCTTGTTG


GAACTTTGGTCTGGGAGTGAAGAGACTCAGAGGACAGATTTCTGCTATACATAAATCATTTGCCAGTCACTCATTTTTCAAGGGCTT


GTCACTGTCAGGGAGCTCCTGGGGATAACACTGTTTCTGCCCCAGCCAGGAGCCCACAGGTTCCCTGCACTTGGTACCAGCTGCACA


CAGCTGTCTCTACAGCAGCCCTCTGCAGAGTTTGGCCTCTGCTGGAAGCCAAGGCATGCTTATTGGTCTTCAGGGAATATATTCCTC


AGGCTTGCGTCTGCCATCCAGTGTGCTCTGTGCCTGACACAGGTCATACCTCCCTCCGGTCCCTGATACCACAGCTTCTTAGTCTGA


GCTGCCCTGCCCCTGCTGGCCTGGTAGTAACAGAATCCTAGGCTTTGAGAGGAAGGTGCAGTGCACACATGCTGCCTGTCTGCCTCC


CAGCAGCTGGGCTTCCCCTGTAAAAGCCTCTAACATCCTCAGCTCCCAGGAGGAAACAAGCCTGCTGCTTGTGACACCAGAGCACCA


ATTTGTCACCCTCTTCACTGGCTCTGGCCCTCACCTCCTCCTCTCCTCTATGGCATCTTTCTTTCCAGGGCCTGCTGCAGCTGGGCT


CCAGCCCGACACTGAAGCCCCACGTGGCTGTAGCCTCTGCTGTGGTCTGTCCATGGGGTTGTGGCTACTGCCTTATTCCTAAGCCAA


GGTCTGTCCGTTGAGCATGTCGTTCTCCTGGGAAGCTTGCTTGGGCTGATCCTCGCCCCTCCTTTACCACTGTGCCCAGCCACTTGA


GAAACATGCAGGGCCCACTCAGCACAGAATGCAGTTAGTACCTGTAGCTCTCGCTCCGCTGCAGTTCTGTGAGCCGCCTGCCTCCGC


TGACCCTAGAAAGAGTTCCGCATTGCAAGTGTAGATTTCAGGAACCAGAGTGTGGCTGATGCTTCTCTTAATTTTTTTTTTTTAATT


ACATTTAGCATGTATGGCAAGGTTGTAAAGGTCAGAGCACAACTTGCATGAGAGCATGTCCCCTGTTATCATATATGGGTACTGGTC


AGGCTGTCAGTGAGTGTTTTTGTCTTTCCATCTCCCACCCTCCAGCCAGCTCCCTGAACTGTGAGGCTTTCTCTCCATTTCCCCAGA


GCAGACCCCAGCCCCCCCACTCTCCATCTTTTCCTTTGACCCAGGCCCTGCCCTGTCTTTCTCATTGAAACCTAAGTGCTTTTCTGG


GTTTCCCTTCGGCCACTGAAGCCCACTTGCTTTCTCTCCAGGACTCTGTGTTCACTCGTATAGTGGGTTTCTGGAAAGCCTTGGAGG


TGGGGCTCATGGTCTGGTGAGTATTTGGGGCCAGGACTGCTGTGTGACTACATTACTTTCTGTCTGCAAGGGACACACACGGGTGCC


CTGGGCCACCCAAGAGGGAGTATGAGCATGAGGTCTCCTCTGAGAGATCTCGGGGTTTTCTTAACTGGGACCTGTTGCGAGTGTCAT


TTTTCATATGCTGGGGGATCATGGCTGCATGTGACAAAAGGCACAGTCGACAGACTTCAGAGAGGCCAGCAGAATTTCTACATGACA


GTTCGCTCAACAAATTTCCTTCTAGAGGATTAAGTGAGTTTAAGAGCTCTGTGTAGAGCCGGATGTGGTGACGCACGCCTTTAATCC


CAGCACTCGGGAGGCAGAGGCAGGTGGATTTCTGAGTTTGAGGCCAGCCTGGTCTATAAAGTGAGCTCCAGGACAGCCAAGGCTATA


CAGAGAAACCCTGTCTCAAAAAAACCAAAAAAAAAAAAAAAAAAAAGCTCTATGTAGGTTTTTCCAGGTAGCAAACATGTGTTCATA


GGGTCTCACCATGTTGTCCAGACCAACCTTGAATTCACCATCCTCCTGCCTCAGCCTCCTGTGTCATCACATCTAGCCTCAAATTTT


CATAGACACCCTCCCCTGCAAAGGGGACTGAAAGGTTGTTCAAAAGTTTGTGTATAAAATTCCGACAGCAGGAGAGCTGAGAGGCTG


GGGGCCGCGCTAAGCAGTGATCAGCTAAGTATGGTTTCAAGAGTCTCGCTAAAACACTCAACGGTTACACGAAGCATGCGAGTGTAT


TTTACATTTCAGCTGACATGTGGGAATTGGATGCGACTGTGATTTTAATAAAATAAATTTCATCATGCAGGGAGAAGAACCAGCCTA


TCTCTGAAAGGAAAGTGCCGTCTATCTCCTCATACCAAAGGTTCCCTTGCTCAACAACTGTCACAGATGCTATGACAAGCTGTATTG


TGCAGGGTGTGGGGTTCGTGAGACGCAGCTTTGTGAGGTGGCAGGTATTGAGCTGTGATTTATGTCCCATGAAAATCCATCAGCCAT


TGTCCCACTTCCAGGGCCGCCGACACTTAGGGTAGTAGCATTGCCTCTGTCCAGGGCGAGGCCAGAAAGGCTTCATTCAGCATGGAG


GTGCGGTGGTCGGTCGGGGGCAAACATAGCCCATTTCTTTTCTCAGGGAAGGTGGGAGGATGAAGGTCTGGGGCTTTTGAGAGAAAC


TTTTTTTGTTGTATTTAGTGTGGTGACAGTACAAATGAAAGAGCCTTACAGTTTTAAGGCACCATTAATTTTAATGTGGGGATCTGA


GCAAGTGACAACATGAAGCTAGATGCCTCATTAATAAATGTGTGCGAGGTATTTACCCTCGTTAAGGTTTTGAGAATGGGGATGAAT


GGCAGACAGGGTCAGGAATGGGAAGCAGGAATTGGTTCTAAGACGCGAGGACCCAGGGAGGTCGACCCAGCTCTGTTAGCTTCTGAT


CTCACTTCGTTCTGTTGAAGCTCTTCATTAGTCTCAAGTGAACTGGCAGAATATTAATATGTACATATTAATAGGCTGAAGAACAAT


GATCAAAGCGGCCCTGTTTATATCTCATAGTAGGCGGTGGGCATTGCTATTGTTTATGTGATCCTTGGAAATAATAGCTTTTGTTCT


TCCTAAAGACTGTCTTCGGGATGACAATTTGACAGAGACGATAGACTTTGCTTCATAGGCAAGCACTAAGTTGTACCCTTGAACGCA


GAGTGGCTGTGATTATCTGTGCAAGCTGTCAACAACATTGGGGCTACTGACTCTACCCCTCCCTCAGGATTTATGGGGTTTTCTTCA


GTGGTGTACCTATGCACTAGTAAACAGTCCTAATGAAACTTGTGGGGGTCGATCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCT


AACACACACACACACACACACACACACACACTCACTCTCACTCTAGTTTGTCCTATTTCACCGATTGTCCCTTCGTTCATTAGGGCC


TAGGCTTCAGTTTCTAAGTACTTCCCCCTTTCTGTGCATCACTTCTTCAACCTAGGTGTCCTTGAAAGGATGAGATCTTGCTGGGCA


GTGATGGCACATGCTTTTAACCCCAGTACAGGAGGCAGAGCAACCAGGGCTACAAAGAAAAACCTTATCTTGACCCCCACCCCCCTT


GTCTCTGTGGCTGGAGACAAGGGACTGTGATTAAGAGCATTTGCTGCTCTTCCAGGGATCCAAGATCAGAACACCGTGTTAGATTAG


ATGGCTCATAACTGCTTCTGTCTCCACTGGACTGATACCTTCTTCACGCCTTTGTTGGCACCTGCACACACAAAGCACGCATATACA


AGCATACACACAAACGAGACCAGAATGCTTTTAATAGACAGAAGAAGGCACAGCTCGCTAACCTCCCTGTTCCCCCGGTGGAGGATA


AGACGCCTTCTGCTGCTGTGTGCTCTTTGTGCCTCTCCAGCCTGATTTTATCCACTCTTCCTCAGTCTCCGAACATTCCCAGCCTGC


TGAGCCCAGGGCCTGGTCTAGGCAGAAAGAATCAATGGTGAAGGACATGAGTCCTTGTCCTTCCTGGAGCCACTTTCAGGGGGCTGG


ACTCATCGTTCCCTGAACTCAAATGCTCTTCTTGCCTTAGCCCGGGGACCTGCCCACACAGAGTCTGTTTGAGTTTTAAGTCAGGAC


TGGGCAATGGTGTCCTGGCCCTATAGAATTAGTTCTCCATGTTTTGTGCCTGTGCAGCTTACCATTTAGGTCTGCCCTCAGATGAGT


CTGTTGTGTGAAGTGTCTGTCTCTAAGGCTGCCTTTTAGTACCCAAGTAATGCCCACTGCTAAATGGTCACTCATAAATGCCTAGCG


GCAATGGGAGTGGCTTGAGGTTGCTATCCATCAAGGGTGTCTTGTTTTCTTCTTCTGGTGCTGGGAACACACACCCCAGTACTTTAC


GCGTTGCTTCTAAGTGACTTACTCCATTCTCAAAAAGAGCCCTGTCATCATACATGCATTTTGACAATTGGACACAGGGAGGCATTT


TGATGAAAAAAAAAAAAACCAAAAAACAAAAAACAAAAAAAACAAAAACAAAGCCAGACCCTATTCAGACGGGTTCTAGTTCAGTTT


GTTAGTGAGAACTGCCGTTGCGGGTTTACTAGAAACAAACATTGACCAGCCATGTCCTGTGGATACATGCAGATAAGGTCAGGATCA


ATAGTTGAGACTTGCTTTACAGAAGTGTCCTCTGACCACAGTGACAGTGGCACACTGTGATGGCATTACCCCCCTGTATGTTGGTTC


AGTGTCATCTGTATTGTGACAGTGAAACTGTGTTGGGCGGTCACCGTCACATGACTTTTAGTAAGAAATCCTTACCAGGGGGATACC


TTGGACTCTGTTTTTATAACCTACTCAGCCATGACCTCAAACAGGCTCTGACTGTGGACTTCAGCAAGCTGTCAGCAGAGCTTCGGT


TCATTCAATTGTAAATGTTAGTTCATTTGTCTTCTGTGAGATCATTGACTTAAAAAAAAAGTCCTTATCATGCACTCTTGCAGCCCC


CTGCCCTTTCCTTGGGTTCCTATTGACAGATCTGTCTGCTCGTTGCTATTTCAGTGGCATTACCGAGTAAGTGCGGATCGTAACTGC


ATTTAGCTAGATTCTAAAGCCGTGACTATTGAAAAGACCCAACCCTTGTCTCAAGGGAGCCCATTTTGTTACTGTTTTCTGCCTGTT


TGGTCAGTGGATAGTGTTGTTGTAAATATTTAAATTCAATCTGGGTTTCTACCCAGCCTTTGATCATTCAGTTCCCAGATAAAAGAC


ACACAACTTTTATATTTATAATGAACCTTAATCAGCACTAAAGCTTGGCAGATGTCTACCTTTTCTATGCCATTATTCTACTTCCCT


GCCAATAACCCCAAGATATGACTAGCCATGTTCCACCTGGGCTGCTCTTACTCCAGTTGTCCAGCCCTCATGGCCATGTTTTCATGA


CTCATCTGCCCCATGGGGTCTTCTCCTCTCTTATCTTTTCTCCATTCTCCTCCTTAATGCCTGTCTCAGACCCCAAACCTAGGAACT


GAAACCCCACCTACCTCTCAGCTATAGGCTGTTGGCATCTTTATTCAGCTAATAGTTTTAAATTAAGGAGCAATTATGTGGCACATC


ACTTGTTCTCTGTCCCTGGGGCCGCCAGGCCTTGGGGTCTAACATTACAATACATAGCAGAAGACCAAACCTCAGCAGAATAGCTAT


CTTCCCTGCTGTGACTGAGGGACCCAGGCACTTCTCTGGTGTAGTTCTGTTAGTAATGTTGGGCTCTGTTTTCTGTAGAAGGGGGAA


GAGGAGAGTGTTCATTTGCCTCTTGCTGACCATAGACAAAAAACAGTTACAAGGCCTTTCAGACTTCAAGAGGATCTGAGGCATGGG


CTCACTGGGTACCCCCTAAGGGGCAAACAGCTTTGGTGGACAGCTTAGCCATACAACCCTCTGAACTAGATGTAGCATATAAGTAAT


AACCTCTGTGTAGACATTTCCATCACACGAAGGCATCTGCAGAGTTTGCACTGTCACATGACCTAAATCCCGTCTCATCTGAGAGTT


TGCTGAGCTTTCGACCCCATTGCACCGTCCTTTCCAAAAGCTGCTGCAGCTCACTCTCTGTCATATAGTTTTATTTTATCTACTCGA


CTAGAGCGTGATACAAGCAGACCAGATTTGACTGTCTGACGTTGAGCCTAGAATCATGTCTGGCACTTGTCTTCAAGGATTCTTGAA


TTTTTCCAGTGGTAGATTTTATTTGTCATCTCTGTGTCAGTAACTCCTTGCTACCCAGCCCTTGTCATAGGTAAGTTACAGCTACCT


GCTGGGTCTGGTGCGAAGACCCTTGCTGTCCTTAGACGCACCTCTGTTCTGTAACCCATTCAATGGTATTTCTGTGCCGCTTGCTTG


TAGTGTGAAAGAACTAGTAAGTAGCATACTTCAAAGTCTCCTTGTAAGTAAATGTATTACTCAGTTATAGGAAATCATGATAACGTA


ACGGAAATATTCTTTGAGATCATGGAGGAAGTTTTTGAGAAAATAATCTCTACTCCACTTGTAGCCTTTGAAAAACTCTGCTTATGA


GTAAGGCAGTCTCTTCATTGCTAATAATAATGGCACTGGGGGAGCTGGAAGGAAGAGACATTTGTCATCCAATGCTAAGTTACCAGC


TTGTCTTGTTGTTTGGGTGGAGCGCTAGTCGTTGGGGAGCAGAAGCTCAATCTAACATCTTCTTGGGAGAAAAAAAAAAAAAAAAAG


AATAAAGCCACCATTTCTATATCAGGGTATTGTGGATTGAGACAGCAAAAACTTGCTTGAGGAGAAAGCTTAAGCTTGTCTTGTGAA


AAAAATTCAGTGGCATGTTGGTGGAAATTCCTCAGGGAAATAATGTCTCTGGAGGTGGAAACATGGAACTACTGCATGCATTCGGGA


GGTCATAGTACACTGAGGGGAAATAAAGTGATCAGTGGTTATCTTAGGATCTTATTGCTGTGAAGAGGCACCATGACCAAGGCAACT


CTTTTTTTTTTTTTTTCTTCCTGGTGCTGGTATTTTATTTCTTTGTGTACATTAGGCCATGAATTCGTATGGAATGGGCTCCAACAG


CTCAGGCTCTTTTCCGTTAGTCCTCACAAAGTGTGCTTCTCTGGGTGGCACAGGCTGGCGCTTCAGCTGCACCCAAGTGCCCTTCTC


TTTGGCTTCCTTTTTCTTCTGGTCGTTCTCCTTCACCCACTTCAGGAAGCTGTCTCTGCTCTTTGAGTGCTTGATGTGCTCAATCCG


CACATTGATCCTCTTGGCCAGAATTTTGCCCTTAACCTGCTTGTTGACAGTGATGCCCACGGCATGCTGGATAACATTGTAGACTCT


TACGGTTTTGCCATGGTAGCACTTATGGGGCATTCCTTTTTTAACAGTGCGCATTCCCTTGATGTCTACAATATCACCCTTCTTGTA


GATCCGCATGTATGTGGCCAAAGGAACAACGCCATGTTTCCTAAAAGGCCTAGAGAACATGTACCGGGTGCCTCTCCTCTTTCCCTT


TGTGTTCCGTCATTTTGGCCAGTTACTGGAAGATGGCTGCCCCAAGGCAACTCTTATACATAAAACATTTCATTGGGGCTGGCTTAC


AATTTCAGAGGTTCAGTGCCTTATCCTCATGGAGGGGAGCATGGCAGCATGCTGGCTGACATGGCACTGCAGGAGCCAAGAGTTCTG


CATCTTGATCCACAGGTAGCCAGGAAGAAACTATCATCCCCACTGGGTGGCCCTTGAGCATATAAGACCTTAAAGCCACGCCTCTAC


AGTGAAACATTTACTTCCACAAGGCCACACCTCCTAATAGTGCCATTTCTCATGGACCAAACACTCAAACATTAGTCTAAGGGGGCC


AAACCTATTCAAACCACTACGTTGGTGTTCTGTGGGCTGGGGTGGCTGGCTGAGTCAAATTTCTGCTTTCTACCAAGTGTAGAGACT


TCATGTGAGCAGAGTGGACTCTGTCTGAAGACAGACCCAGCGGGAAGATGTGTTGGTTTGGTGTTTGGGGTGTTTGCAGATGCAGAA


GACCATCAGGAATCTCCCTGTGTTGTAAAGTATTTCCATCTACTGCCTTTTAAAGGGGTTTCAGGCAGAAAACAGAGCCTAATGTTA


GTAAAATGGGAAAAAAGCTGCCTTAAAGTATCATTCAAGAAAATAGAGTGCACACTTAACGTTTTTGCATATATAAAGGGTTATAAA


TCCTCTGGGATCTCCTAGTTGCTAATTTATTATCCCATGCTTACTCATTGATAAATTTTTCTTCTTGCAAAAAGATAGATGAATAAG


GGAGAATACCAATTTTCCACCTCATAATAAAACTAACTCATTAAATTATTGCGTGTGGGCTTTTGCTTTGTTTGTTTTCTTTTTCTT


TTTTCTTTTTTCTTTTTTTTTTTTCTTCTCATGTTCTGGTTGGAAGCTCAGGCCCAATACATACTAGACAACAATGAAACTTTTCCA


CCCCCTGGAAAGTTAGCTGAAGTATCCATCGTGAATATACAGTCCTATTTAGCCACTTTTATAGTTTAAATTATTCTTTAAGATTTC


CAAGTTTGGAAGGTTGGAAAGAGAGAGTCTGATGGCTTAGCCCCATCCCTGCCATTTTGCTACAAAAACTAAAAAGAGACCTTGACT


TTCTGTGGTCTCAGATTGTTCCATCTGCACGTGCGTGAGTGAGTGAGAGTGTGCGTGCGTGGGTAGGTGCGTGTGTGCGTGGGTTCG


GTGCAGGATAACTCGGAACATATCAATCAAGCCAGAAAGAAAGCAGAGCCCTGGGTAGGGTTCTGCCCTTCCACGCTAATGGGAAAA


ATTGGTGCTTTCTCTTTGCTCATTCTGTGTCATTCTTACTAAAGTGTGGGTATTTGCAGGGCTGTTTACCCTACTTTGCCCACGGCT


GCAGATAAATTATTATTTTGAATGTGTTGTCTCGGAATCAGAGAAATCCTGCTGCCTCACATTTGGACTGTGGCCCCTGCACAGTGT


CATGGACTTGACTGTGGCCCCTGCACAGTCTGATGGACTTGCCGCACTGGGGCATCTCTGCTTTGCTGAGACTCTCTGACATATGCA


GGTGCCTGTGGATGTGGGAGACTGATGGAGTAGCCAGAAAAGCAGAATAGAGACCAGAGGAACCGCCAGCTGGAATGTGGAGTTGGT


AGAAGGAAGTTCTCAGAGCATTTTGATGCTGTAGATGTGTCAACCAGGAGTTGCAAAAGCGGCTCACCTATAAAGGGCCAGCAGACT


GAAACCCCCAGTGAGGGCAGAGGGTGTCTGCATGCAGTCCTTTCCAATGGCTGCTCGGAGCCTCTTTCCACTTCCTAACACTAATCT


TAGTTCTGAACTCTTGTTAAAGCAGAAGATTGGAAGCTGGGCGTGGTCGCGCATGCCTTTAATCCCAGCACTCGGAGGTAGAGGCAG


GCGGATTTCTGAGTTCCAGGCCAGCCTGGTCTACAAAGTGAGCTTCAGGACAGCCAGGGCTACACAGAGAAACCCTGTCTCGAAAAA


ACAAACAAAAAAAAAAAAAAAGCAGGAGATTGGGTAGCAGAAGGTTAGAGTACCCAACTATGAATTATAGAGAAATGTTTTATTTTA


TTCCTTATCACTCTGCAGTTGAGCCTAGGGCCTCATGTATTGTAGGCAAGTGCTCTTTCTGTGAACTCCAGCCCAGCCCATTTGTTC


TCTTGGATTTGGGATGGGAAGTTCTTCAGGCGCATATACCTTTTATCTTTGTCAGCTTGCTTTTAACCGAAGTGGTTGAAAGTAAGT


ATCTGAGTGATTGACAAAATGGCCCAAGCCCAAACGATTCTAAGGGAGGGTTCTGTGCCCTCTTGTGGGTTTCAGCCAACTAAGTTT


TGATTCAATAAAATCCTCACCCATAGATGAGTGGCATATTATACTATAACAAACATCACTAGCTAGCATGGGTAGGACTGGGGAATC


TTTTGCCGTCATTCAACTTAAAATTTTGGTTTAAAATCAACTTAAAATTTTGGTCTGCTGTGGACATGTCACACTTGTGAGCATGCA


TACTTGAAGGTTTAAGCTTGAGTGTTTAATGACGAGATTTAAAAAGTGAAGAAATTTAATTTTTCTCATGTGTGGGTATTAATTTGT


ATGCATGCTTGCACACACATGGGCACTCGTGGGTGAATGTGGGTAAGTATGCCTCCATATGGACATGGATATAGGGCCTTAAGTTTG


CCGTTGGTATTTGCTTTCTGTAGTGTCCCTCAGTCGAACCCAGAGTTTGTCAGTATAGCTAGTCTTGCTAGCCAGCTTGTTCCCATG


GGCCTCTGCCTCTGCACTGGAATTACAGGAGTCACCATGCCCACCCCCATTATGTGGTGCTAGGGGTTCGGCTCTGGTCCTCTTACT


TGTGTAGCAAGCAATTGAACTACTGAGTTCTCTCTCCAGACCCGGACTGAACAACTTTGAGTTAGAAACCCTTTTATGTTCATCGTG


ACCTTGTTTGCGTCCCTTTACCTGCTCTGGTTGAGTTATCAGAAGTAACAGCAGCCCAAAAAAATCCATTGCTCTCTTACAGTCTCC


ATGAACGCCAGACATACACATTGTACCTAGACATATGTGCAGAAAATAAAAACATACACATTAAATAAATAAATAGTATTATTTAAA


TGAAGATCGGTCTGAAGGCTGTTGCAGGTCCTCTGTGTTTGCCGAGGACTTGTGCTGTCTTCATTGATTATCATATTCACAGTTTCT


GAAGAAATTACCCCAATATGCTGTAGCTCTTCCTTACAAGTTAAAGCCAGCCACCAAAGCACAGTGGGTGCTGAGCAGTGAAAAAGT


ATCTTCTCTGGAGTCTGAGTCCCGCATCCTTTTCGTCGACTGCACGTCCTTCAACCCTCACCTTCTCTTTTAGAACATTGAACAACT


CTAGTGTGAGACGCGTGCTTCCTGTGTCAGTAACTAAACACGACTTGGCAACTACGGTAGGTAGTACCAAGTACCACAGACCCTGCT


ACTCCCGCACAGATGCGGGTGATGTAGAAAAGGTATGCTTCTTCTGAGCGCTGAGAGCGGGGAGCCAGCATCCTGACTGTCCTGACC


TTTTCTAAAACTCTGTTGTGAAACTGCAGCTCTGCAGAGCCTCATGTTTGTATGATGGTTTGCATCATGTCTGCACACAGGTTTGTA


TCATGACACACATACATTCATACTTACATACCGGAACATGCATCCCTGCCCCCTCACCCCCCCCACTGGGCGGAGGAAAAAAATCCC


AGATAAAGTACCTTTTTTTTTTGTCCTTTTTATGACATTTAGTTGGCATGAGTTACCGCCGTATAATCATCTGTCTAGTAGAACCTA


ACATGTTTCTTGGCTCGAAGTCCCTCTTTTGTCCTCTCCTCCTTTCTGCACTCTGTTCTTAGAGGGAAGTCACTGTGCACACATAGA


CTTAATGAATGGGAACTGCCCCCTAACCAACTTGGGGTTCTCAATAAATTACTTGGAATTCTGTTATATTTTATGTATGTGGCTTTA


GCAATAACTTTGATAGCAGAATGCTGCTGTAACTGTTGTAGTTATAAACTCACTGCGGTGGCCATTTTATTCTAATTTGAAGGGAAC


TAGTAGCAGCCAGACAGCCCTGAGCAGAGACCGTGGAAGCAGAACTTCTACCAGGGATTGTCTTACTGTGCCAAACATGCCAGATGC


TGTCCACGCCTGTTCTGGGTCAAGACCCAGGTCTGTTTGTGTGCTCTCTTCTGCTTCAGCAGGCTCACTGGCATTTCTGGAGACCAC


AGCTTGTGTGTCCTATCTGCATTTCAGCGGCTATGTATCCTGTTTAGCAAATGCTAGTAGGAAAACATATGCCATTTTGACATGTTT


AGGTATTGCAGGGACATAGTTGTTAATGGGTATCTTTTATATCCATTAATTGCCTCTGACTTGAAGTTACTCCTCATAAGAGTAATT


AGGATATAATTAAAGATCTTCAAATGTAGTCAAATATTTAATTACTTCATATTCAGCACCGTGTGTGCAGTTCTTGGGTTGTTTTCC


TTTTTTGTTTTCTTTTTTTGAAAATATTCCAATAATTTTTTACAAATTTATTAATTAAGGATTATATTTCACTCACTTTTGGTGAGC


ATATATAGTCAGTGAGAATTAGGTATATTTTGAAAGCATAGAAGTCTACGTATTTTGCCACTGGCTTCAGCAGAGAATTAGTAGCGA


AGTCACGGTTTTGCCCTTGCTCAGTGTTTCATGGATGCGCTTCTAACCCTGCCGTCAGCCACTGAATATGAGTGGTGATTGTTCTCA


GCCTCAAGAAGAAACGGAGGTTAATAGAAGTAAATTTCCCAGTTTTAAGATTTTTCTCCTATCAATTTTCCTTAAACTCTTGGCATC


TGACCCTACATCCCTGGTGGTGAACATGACTAAAGCAAATGAGAAGTAATGTAAAAGTTGTTAGCAGAAGAATTCCAAGGCAGCAGG


TAATTCAATAACTCCCATTATCTTCTTGAGAACACAAGTTTATACTGTGGGGGTTTTGGGTTTGCCCTTTATATATTTTTCATATAC


TGTCATTTATGGGAAAGAATCCTATTTAATAGACAGACACAGAACTATCGCCATGTTCCCAGTGTTCCTCGATCCTCCTCCAGGCTG


GCTTGGTATCCAGGTGACTCATGCTCTGAGCAAGGTTTGAACGCCGCCCCTGCTGAATGGAAGGCAGCTAGGAACCCCCGAGCTTCC


TGAAACAGGGAGGCCATCGTCCAGCGGTGATGTAATTGTCATCTGTACATCCTTCTGCGGGAAGGATGGGTTCACTTTTCCACCCAC


AGCGTTGGCACACAACTCCCCTGCGTCTCAGGCCAACACTGTGCAACAATTATGAGGTCCTAGAGCATTCCCGGCAAGGCCTGTGTG


TACATCCTGTGTGCAGGACACACATGTGGCTGTAAATGGATGTGCTTGTGCCCAGTAAGTAAGTCACCAGTCTTACTTACTGTATGG


GAAGGATGAATTGATAGCATTTCTGTTTATGATAGAATTAATTAGAATAATTAATCACCGTCCTCCAAGGATGTGGTAGGTCTTTTC


TATTTAAAGGGGAGGATCGGTTTTCCAAGTTTTTTTGCTAGGTTTCTGTTTTGTGTTTGTTTTGACAAGGGTCTTACTCCATTGCCT


TCCAACCTCAGTTCCCAAATAGGTAGGACAGGACTTGTGTGCCACTGAGCATGGCGGATAAGGTGTCGTAAGTGGCCAGAAAAGGCT


TATTTGAGGCACTACGTGAAATGAACCTCAATTAGTGAGACTAGCCCGTTCTTCTAGGAGAAGATCAGTGGATGAGAAGTGGGAGAG


TGAAGGAATGAAGACTAGACCTGGATGACTACAGAGAACAGCACGTTGTGAGGCTGTGTAGGTAGCAGGGCAGAGGTCCAGGGACCC


ATGTGTTGTCTCCTCAGAAAAGAGCATGTGTGACATGTTTTCTCACACTGAAAAGACTCATGAAGCCAACACCTAGGTCAGGAGGCA


GCATTTCTGCTACCATGGGGGCCTTGCTGGATGCCACACCTGTTTCGGTCTTTGTAGGTCAAGTTCACTTACAATCTTGCCTCAGGG


AAAGTTCTGGAGCTTGCAGTCTGTTCCTTACAACCTCTGTGATCTAAAACGTAGTGCAGCATGCAGGGTATTTCCTGTGGTCTTTTC


CCCAATTCTCGCCTCAATCCGATGCCTGGAAGTACGTGGTAAATGTTTATTTGTTTCTATATGTGTTTGTCATGTGTTTTCTCTTGC


TTAGAAAGCAAGACTTGTCCTGTGTATCCTTCCTTCATGTCTAAGCCAAAACTTTTGTCCCATTTTCATGCATATTTAATACTCATT


TTTGACACAGTTTATATTTACTCTTTGATAACAGAATACTTCAGGATGTGTCGTTCATTAAATCCAGAATTTTGTATAAAAAGTCTG


TAGGCACCTAACCAAATTTAAACTGTAAATAAACTAGAGGTTATACAGCAATTTCAGACAGCTTTGTATTTAAGATGGGACTTTTAA


AGGTAGTCCATAATGAATCTTTTTTTTTTTTTATTTTTCCAGAGAGGGTCTCATGTAATTTAAGCAGATCTCAAACTCACTGTATAG


CTGAAGATGACCTTAAACTTTTTTTTTTTTTTTTGTTGGGGCTGGAGAGATGGCTCAGTGGTTAAGCACACTGATGGCTCTTCTAGA


GGTCCTAAGTTCAAATCCCTGCAACTACATGGTGGTTCACAACCATCTATAATGGGATCCTATGCCCTCTTCTGGTATGTCTAAAGA


CAGTTAGTTACAGTGTATTCACATACATAAAATAAATAAGTCCTTTGAAAAATTGTTTGTGTGCTTGTGTGTTTGTGTGTTTGTGTG


CTTGTGTGTGTGTTTGTGTGCTTGTGTGTGTTTGTGATTGTGTGTGTATGCATGCATACACAGTGTATGTGTAGTAAGTATCAGAGG


ACAACTTGCAGGAGTCTGTTCTCTTCTTCCCAGAGATGAAACTCGGTTTGTCAGGCTGGCCACTGCAGCATCTTGACATCCAGGCTT


GACTTTCAGATCCCTGCTGTTACCCTCTTGAGTACTGGGATGAGAAGTGTGTGGGTACCATGGCACCCACACAGTGCTGGGGACCAA


GCCCAGGGCTTTATGACTGCTAGGAAAGTGATCTTCTGGCTAAGCTGACTCCCCAGCCCTAGAGTGAACTTTGATGATGATGATGAT


GATGACGATGACGACCACGACGACGACCTGTACAGTGGTCTTTACCTGGCGGCAGCAACTCAGGTTGTGTAGCTGGTGTGGGAGAGA


ATATAAGCACTTTCCTGTCTGCTTGCTCCCTGTTGTTTCACACCCGGAACAAAGAGAGTGCAGCTAAGTCAGTAGGTTCAGTAGGCT


CATATTGCAAGCCCAATGAATTTCAAATAAAAAAAAAGTTACTAAAATGCTATATGCTTGGCTTGGAACCAGATACCTTAAGTCTTT


TTAGGGAGTTGGGGCAAGGTGCTTCTTTTTATAAGAGAATTTTACACTAGAAAAAAAATCAAGTGTAACTAGTGGTCTATTTTGAGA


CCAACCCTTTAGAAAACGCTTTAGGCGTTTTCTTTGGAAGATCGGATCTGATGTTGTCTTGCCTAAGCTGCTGTTGTTTATTTTGGC


CTTCTGAACTGATGATCGTCCTTAGAAGCAACTTGGGGCCGCCTCTGAAAATGCCAAGATGTGTATTTTGCCACTGAGACATTCCTC


CCATAAAAGCGTGTGAATAATTTTTTATGGAGCGAGTCCATTCTTACGATGTCTTAAAGGGGGAAGGATATCATTTTCAATCTAGAT


CATTACCTTGTTTCTTATTTCTGAATGCTCATGCCCCCCCCCCCCCCACACACACACATTATCTAGATCGTGTGATTTAGATGGACC


ATTTGGAAAAGCTCTCTCCCTGCCTTCTCAATTGTTTTTCTAATTTTTGAAATAGTGCCACCTAGGGATAACAGTTTTAAGCCACCT


AACATTTAAAATGCATTTTAGTGTTTTTGGCCTCACCTTTTAATTTTCTTGCTTCTTGGAGAGAAAGAGTTGACTCTAAAATGCTAT


TTTATCGGTTCAGCTTTTATTTAATTTACTCTAGTACGTGTAGATGGAAAATTAGGCGATTTAATACTCACAATGTTATCTGGCAGT


TATTTTACTTACTGTTCCGTTTTAAGATGTTAGTTCGTAAAATACAGCCTTGAACTTATCTTTCACATGAGATGCTGAAAATGTGTA


GTGTTAATTAAATGGGCTCCGTTGTCGGTTAACCGGCATGTGGGTACATCAGGAAAGGTACCAATGGACAGGTCACGGATCATTTTA


CATCCACCGCATACGTGAGAACGCCACATGCTCCAGCTGCTCTTGGGGAGGTGAGGAATCAAGAGAGCAGAGGTGACTCTGTTCTCG


GTGCATTCTGGGAGATGGAGGATACAGGCTCACATGCTAGAAATGCCGTATGCCGTGGTCTGTCTGAGTTCTAATGCTCTGTCCATT


CCTTGCCTTTGCTTTCTCCTGATTAGCTTCCTTCTTCGCCTCCCCTGGCATCCCGACAGTTTAACATCTCTAACAGGCAGGTGTAAT


ACTTGACTAAGAATCTCTGGGTTTGGGGAAAATCCTGGAACGCTTGTGAAAAAGCCAAGCTTATAAGCCTGCGTGGGGAGGTGCAGC


TATGCGCCTGTGTGGGGAGGTGGAGCTACGCAGAGTCCTGGTACTTGCCTGCTTAGCTTATTTGGAGAGCCCCAGGCCAGTGAGAGG


TATTGTCTCAACTAAGCACCCTGGAAGATGCCTTCTAAGAACTCCAGAGATGATCCTTTGCCTCTTGACCCATACAAACATGCATAC


CCACCCCTTACACACACAAACACACACACCACACGTGCACACACATACTTAAGCATTTGTACTTACAAGAATCTCAGGTTGGCCTCT


CACTGCCTTGGTATTCCCAAGCCGAGCCCTGTAGCACGGTAGGTAAGAGGCAGTGATCACTAGGTCTGGGTCGTAGAGCTGCCATTT


CATGCTGCATCTGAGCCGCCAGCATCATGCTGCCCATCAAGAGACAGGAAAAAGGGAAACCGACTTGTAGAACCTACCAAGCTTCAG


TGTCCAGAGAGAGGATCGACAAGGGATGAGAACTGATTCATTAAATTATTAGCTGGACCATTTAATATAGCATATATACTATATCAC


ACACATAGTTGTGTGTGTGTGTGTGTATATATATATATATACTTACATATGTATACGTGTGTGTATATATACATATGTATATATGTA


TATATACATATGTATATGTATGTATATATAGTATATATATACACATATATACATGTATGTGTATATATGTATATATGAAGTATATAT


GCCTCTTGGCACCATCCTATGCCAAATTCTAAATAATTTGGACTTTAAATACTTAACTGGTCATTTCTGAAGGGTAATAGACTTAAA


AATAGCTTTTTTCCCTTTGTTTTGCTTTAGTATCATTGAGAGAAAATAACTTCATAAGTGGAAAGACATTTTAACCCCCATGAGTAT


GTTTAACATTGTTATACATGACACGGAGCAGGGCATACAGCGCAGTGAGGGAGCACCTGCCTGCTATCCATGAGGCCTTGCAATCCA


TCCTCCACACCATCTAACAAACAGCCACAAGTAAAACTGAAATGGGTTATGGATTAGAACCCCTTTTCTAAGGGGTTATGAAGGGTT


TCTGGCCACGTGTCTCTTAGGAATCCTACCAAGACCCTCTCACATGCTCACACCTGTGAGGACCTTTCCTGAGAGAGGTGCTGATCT


GTCATTACATGTACAAAGAGCCATCCCACAAATGGTATCCAACCACCGATGGCTAATGCCTTTTGTCGCTAGAGAGGAAGTGGTTCC


CCTGTCTTCCGGGAGTTAAATAACTCTCAGGTGGGTGTGATGCCAGTTAGAAAGAGATTGAGCCTGAGGATGTACTATTGGCTTTGT


TAATGAATTTGGTTCATACGAGATTAGAACGTAATGTAATATGGATGAAGCTGTAATGAAATGGGCTTCCTTGGCCCTTCTAGTTTC


ACGGGCAATGGCTGGAAAATCACTGCCAGTTGATCTTGGCTCAGAGCTCGGACGCAGGCTCAGACCCACCTCTTGCTGTTTGGAAGA


GAAAGGAAACATGATAAAATATATGGCTTTACTCTCAGAAGCAATTTATGACGGCCATTTAATAAAAATTTCAGGAGCTTCCTTTTC


TTCCGAGGAGGAGAGCCAGGGAGTCCTGGTGGGACCTTAAGCTTAAGGTCCCGTGTGAAGGCCCTCCACAGCCTCTAGCCTTCCCAA


CTTCCTGCTTGGCTACACAGGAAAAGATGGAGGGATGGGTGGGGTGGGGGGTGGGGGCTGAAGACCTTTAACTCCATCAAGGTTCCA


GTTCTGCTTATACATCTTGACCCCCCCCCCCCCACTCTGAACTCAAGCCTTCCTGGTGAGTTCTGACTTCAGCTTTGTGGGTGTGGG


AGGGGGCTACTGAGAGCCCCACTCTTATACAAACTGACACGTGTCCAGCTTGTGTCCAGCCCACTCTGTCTCGTCCCGTGGTTCTTT


TTCAGCCTTGAGTGAAGCAGTATTTATCATTCAGGATCTCCATGATCAGCAGATACCAAGGACCTGGAAGGACCTGAAAGGACCTTT


GGTCTCTAATGTTTACTTACACCAAAGGGCCCTCAGGAAATTCTTAGGTGCGTGAGTTTAAGGCTTTCTCCTGGCAAGCGGGTTGCA


GTGTGGCTCACTTCTGCCATTCCTCTTAACCTGGGAGGATGTTTGTTCTGGCATCCACTGCCTGTGCCCGGTAACCATGGTTTAGAC


AGTTTTACAACCAAAATTCACACAGCTTCCTCTTCTGCCTTGTATCCTTCAAATGCTTCCTGACAATGACCTATAATGAAATATGCC


TTCTAGCATGGCACTCAGTAAGCATAGACATATGTACATTTCACACAGTACCCTTATAAGAAATATACATACCATATTCTGAGAATA


TATCTCCTTCTGTGACTAGCTCATGTTTGCAACCTGCAGTGGGAAAACTGCCCCCAGGCACTCCCCCACCCCCCAGAGATGCTCTGT


ACACTGCGGTCTTTTAGGTCATTGTAGTAGAGGATGGCTTAGGGCTAAACGCTGAGCATGGCAGAGCCAAGTGTGTGGCCTTTCAGT


GGCAGCCGAATGTTCTGGAAGAGTGGCATCGAGTGTCCAAGACCAAAAGTTCTGGCTGTCGTGTTCTGTTCCATCTGGGCCCTGACC


TTCCCATCTGCTGTGAGTCTCTCAACCTCCCTGAGTCACTTCCCCCTCATGTACAATGAAGGCATAAAACTTTTTACTCTCAAATGT


TGGGAGGATTGATATATCATCCCTATATTAATGCACAGATATTAACAGCATTTATAATACTAATAGTCAACATTTATTTAACGTCAT


GTATAGCTTTTCTAGGTTAGCAGACACTTGCTGTTATAATGATTAATGCTGTATCTTAATTTTAGACACATCTCTAGTTGGATGGCA


TTTGCAACCCATTAAGAGTAGGTGGCTTACGTGTAGGGATAATCCCCGTGTCCCAAAGCGTCAACTCTAATCAATGTGATTAAATGG


AAACAATAAGTTGCACAAGGTATTTACAGTCTAAGCTGGTTGAAACTCCCTGTTACATTCTGCACACTGACGGACTTATAGACTAAC


AGAAATCTCTTAGTTCCATGATGGAAGATTCCGTGAGCATTTCATTTGCTATTGGCCTTATTCAAGTGCCTCGGTAATGTTAGAAAT


CTTTCTCATCATTTCTTTTGCTGCCTTTCTATGTTGGTTTCATTTCTAGGCAAGCTTGTCCCCAGGTAGTGCTAGAAACAGCTCTCA


GCTACTCAGTTTTACATTCTCCAAGCAGAAAAACAAAGCCCCAACATGCTAGTTTTAGCTTAGTCCTTTGATGGGCAGAGTGATCAG


CTAGATGAAGGCTACCCCTTGCTGGCCTTTTCAGACACTTGGCTAAGAGAGACAGTGGCTGTTGGACACCATGCAGCATATATCCCC


CCTGGGGGCTCAGCCCATACTCAGAAGCACGGAGTACAAATGGAGCGCACCACTCTGTGGGGATGTCCCAGCAGACACCCGTGGTGC


ATCAGGCATCTCCTTCAGTTAAGCTTAACTTTCTTCATAAGATAATCAGCTTTGAATAACCCCCAACTGGGCAACACTAACACCAGA


GACCTTATTGCAAACCACCCTCACTTTCATTCTTGATGTACACTGCGGTAGTGCCTGAAGATCTGTCATCCCTTCTTTAACTTCCAG


CCCATCTTTGTGTCGTCGTGATTTAGAAGTTATCCCTTTAATAGTGGTTGCTTTCATTATGAACCACAAAACTCAGAGGTGGACTAC


CCCACCTCCTTGTGGTTGCTCCCTTTCATTTTGTGATCCAGCTAGCCCCAGGCCAGCCCTGCTTTATGCAGTTTTCCTTTCATCCAC


GGGCTGAGCATAAGTGTAGTCTCTCATTTATTAGTGTCCCTTGCGACCATACATACATATGTCTCTCTCTCTCTCTCTCTCTCTCTC


TCTCTCTCTCACACACACACACACACACACACACACACACACACACACACACACACACACGGCAGTGAGTGCTTTGGGTTTAGTGGG


GCCTGCAGATGGTACAATATGGTTGACAGGGAATTTAAGAGAATTATGAGTCTAGAGCCAGAAAAGTTCTGACAACACCTTAGAGCC


TTTTATCTGCCATGTGAGATAATTAATTAATTAGATTAAATTTGGAACAAAGCAAGCATACCTTTATTCCTAAGACAATATTATGTT


GCATTATTTAAAACTGTATAGAATTGATAAGTCAAATATTGCAATGTTTTATATATAAGCAAAGCTATGAATTCAGATAGTTTATGT


TATTTTGGGGAGATATTGAAAATTCTCTGAAGATATTAAAAATTTCAAGTCCTGGAAATATTATATGGTCAGGTTCACGCATGCATA


TACATGCATCACATAAGAAGTGCCAGGTGAGCCAGGCAGTGAGGCTGTATGCCTTTAATCCTAGCACTCAGGTGGCACGGGCAGGTG


GAGCTCTGAGTCCGAGCAGCTTGGCCTACAGAGCAAGTTTCAGGATACCTAGAGCTATACAGAGAAACCCTGTCTTGAAAAAAATCA


ACCAGCCAGGGGGAAAAAATGCCAGGTGAGACACATGTGTCAGTTATGCTTTGTTTTCTTATGGGAGCTTGGGGGCCTAATAGTCAT


TCTATACAGCTAGAGTTGAAGTACAGTTGTTACACTGCAATTACGACAGGAAATGGGTGAGTTAAAGTGGTGAGGCCACATTTAAAA


TCAAAGCCATATGATACATGTTTATTTTAAAAGTTCCATGTTGATTAGCATTTTGTTTTCCCTATTACTGTCCTGTAAATGGAGACC


TGGGTGTTCCTTCTCCCAGTGATCCGCCACTTGCTATAAAATTATAAGCACCAGGAGTGTTTGGATGTAGGTCTGTGTGGCCCCTGA


TTCAGTCAATGCTTCCTGTATAAGCTTTAGCACTAACTTATCCACCACAGTGTCCATTTACAAGTCTACAACGTGGGTCTAGACCTA


AGAAGCCTTTATAATAAGCTGAAGATTTTCCCTGCATTTTCCTCTAGTTCTTTATGGTTGACTCTCACACCTGATTCAACGGCAGAC


TGTTTTCATGGGATCTTTTATAGTCAACAAAAGCGGTAGTGGACCAACTTATTTGAGTGGGAAAGGTAGACCAGGCTGGCTGTGTTT


AGACATCAGTAACATCAAGGATTCCTCAGAAAGAATGGTGTTCAGTTTGCTGTTATATGTCCACATCTGCACTGTAGCATCTAAAGC


CCCGTTGACATGGTTTTCAGCCCAGGAATAAAGCAACATTAAGAGAAAGCCACCACTTTTCACAGTTTAGCCCTTCCTTGACCTGCA


TCATGATTTGATTAGACGCGTCCTGGACAGGCTGTGTTGGAACACTTGGTCCTCAGCTGGGGTGCTGTTTTGTAGGCCATGGTGCCA


TTGGGGGGGTAGGGCCTAGCTGGAGGAAGTAGACTGCTGGGTGCTGTATCTGTCTTCAGAATTGACTCCTGCTTCCTGGTGTACCCA


GCCCTGAGCTGCCTGCACTGCCAACAGGATTCCAGCTACTGTGGCTCTCTGCCTCAGTGGACAGCATCCCCTCAAACAAGGAGCCAA


GACAAATGCCCCACCCTCTCACTGGTTCTCTTAGATGCTTGTTACAGTGTGAAAAATGCAGCCCAGCTGGGAGGTCAAAGACTAAGT


CCACAGAGAATGAAGTTTATAAAGCCACTCCATCTGGTTTCTTGTTTGCAGACGTAACTCACGCTGTCCTAGCTAGAGAAAGCCGAG


AGAAGAATGTGAATATTGATATGTATTAGTTACCTATCACTGTCTTCCAGATCACCCAAACCCTTGCACTGTAAAGCAAACTTAAGG


TCTCACATGGTTTGAGAATGAGAAGTCAGGGAATGGCCTAGCGGGCTGGTCTCACAAAGCTGCAGCCAGGCTGTGGGCAGAGGCTCT


CTAGTCCTAGGGTGTGGGGAATCTGCCTTCAGAGTTCCTCTGAGAGATGCTGGCTGGACACTTTGTTCTTACACGTAGACCTCGCCC


AAGGGTTGGACAGCATGGCTTCCCTTAGTGCCGTGTGACAATGACCAAAAGAGACTTGATAAGCTCATTTCACATTGACTGTCCATC


CCATGTTCAGTGTTCTGCTGGCCACACACTTGGACTGAGTATGTCATCTTGGCATCGGGAAGTGGGGTGTTACTACCATACATCATC


ATTATCAGTGACCAGCAGTGCCTCTTGTGAAGGTTGCCAGCCACAGTGTACAAATTATAATTTTGCAATGGCAACTTAGCTTTGTTC


CTAGCGTCCCCCCCTCTTCCTCCCAAAGTTTTGCAAACAGTAAAAGTCCACCAGGAGATCACAGTGATGGGAACACAGTGATAAGTG


GTAGGGGCCTCCAAGGAACTATTGACTGCTGTCCTCTGCTTGAGAACTGAGAAGCCTCTGATTGCCTTTGAAGTCTGTGGTGTACAA


AGAGTGCGGCCTAGGAAAGCGGAGAGTAGCGGCAGTCCAGTGAATGAGCGGATCTGGGTCCACCTTGGTTTTGCCTTCATCCGTCCT


TTGAGGGACCCCACACTCTGCCTCAGAGATGGCAGGGGGTGTTTGGGATTCAGTCCAGTGGAAACTTGTGAGAGGCTCATGACTCCT


TAACCTCTTCCTTTCTTGGATGGAGAGAGACTTTCTTTGTGTTTGTTTGTTTGTTTGGTTTGAGTTCTTTATATATGGTAGACACCA


ACCCTCTGTTCGAGCTGTAGCTGGTAAAGATTTTTATTTGCTCTCAGCACGCCGCCTCTTCGCCATCTATCACGATGGCATCCTTTG


CTGTCTAGAAGTTTTTTAGTATCGTGAGGTCCCATTTGTCAGTTGTTGACCTTAATGCCTATGCTATTGGGATCTTCTTGAGAAAGC


CCCTTCTTATGCCCTTCTTGTGATCCTCCTGCCTCTGCCTCCTTCAGCAAATCCTACCGGCGTGCGCCACCACTACCGACTCTTATG


CCCTTCTTATGCCTCTAAGCTAAAGACTATTTTCCACCTTCTCCTGGAGACTCAGGGTACTCAGTTTTACTTTGAGGTCCTTGATCC


GTTCAGAGCTGAACATTGGGCAGGTTGGTATTAGGAGCTAGCCTCATTCTTCCATGTGTAGCTATTCCGTTTGATCAGCACCATTGG


GTAAAGATGCTGTGTTTTTTCCCAAATTATATTTTTTGGCCAAGAAAACAAACAAACAAATAAACAAAAAACAATTACAAATTTGGG


CAAGAAGAAATACAAATTGCCGAGAAATATTCTTAAAGCATTCAGTGTTCTTAGCTATTAAAGAAATGTAAATTACAACTGGTGAGA


TTTCCTCTTAGTCAGAATGGCCAGAATCACATGTATGTAGAAAACAAACCCTGGAGCGGATGCGAAGCGCAGGAAGCATTTAACCGT


TGCTGATAGCAGTGCAAACTGGTTTGACCAATATGGAAATGAGTGCAGAGGTTCCTAAAGAAATTAGAAACAGATCTATCGTGTGAG


CCAACTGTAAACTCCTGGGCATATCCCCAAGGACTCTGTATCCTACCACAGAGATACAGATTCATCCATTCATTGCTGTTCTACTCA


CAGTAGCCTGAAAATGAAAACAGCTTAGCTGTATAGTACCGATGGGTAGGGAAAATGTGGTACATAGCCACAATGGAATATTATATA


CCTGCTAAGGGGAATGAAATAAAGACAGGTAAGTGGACGAAGCTAGAAATGAACATTCTAAGAAAGATACCAGCCCCGGAATGTTCT


TTCTTACGGGTGAATGCTGACATTGAATCCTAAGATTCAATGTGTGTGCTTACACTGGAATACATAGAGGAATCATAAAACTAGTAA


GAGACGAAGAAGATTTCAGGGGAAGGGAGATAAATGCAGGAACATGAATGGGGACAGGGGAATAATGAAGCAGGAGGGGTTAAAATT


GGGTGGTGAATGGGAAGGCCAGGGTACGGGGCGTGGGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAAGGAAGCCATCA


TCCATGACTTAACCCTAACCCTGAGTACAACAAACCTTTGAAAAAGCACATGGAGACCTGCTTTTGCAGTTGCCTCTTGTTGGCCAG


TAGGAGTCCTGTAGGTGTACCCAAACATTATTGTGCTCTTATCTTTGGTCATCCTCCAGGACTTGATGGTTAGAGTCTATTGCAGAA


GGCATCATACAAGTGAGTCATGTATGGAGAAATCAGGCTGGTACCCATTTGGAAACATCACGCCTACTAGTTACCTTTTATACTGCT


GGAAGATTCTGTACATACTACTGGGGAAGAAAATAATTAACCATGTTGCCCAGCTATGAACCCTGTGAGCTACATAGTAATAACTAG


CCTGGCAAGATATTCTCACTGATGCAGTAGGGATACCAGTGTTAGGGGTATAACCAACCACTTTCTGCTTTGATTAAAAGCCTGCTG


CACAAGATGGAACCCATACCTTGTATCATTAATTTGGCCAAAAATCTGTGGCCTGCTGGGTCATAGTCTCTAGGGAAAAAGCGTAAA


ACTGTTTATTCTGCTAAAAGGACATAGTTTTAAACTTCCACCTAACCCCTTATCTTTATAAGCATACATCAGTGCATCTCTCAACCT


ACATCATAGAAGTTTCTTTGCAGTGCATAGGGATTAATGCAGAGACCAACAGCTGGTCGGTGCAGAGAATAAGACTATAAAGTGTTA


AACATTCAATGGGAAATTTATATCATACTTAGTGTTCCCAAGGCTCAGGAGTCATCTTGGGAAATGGATTTATTTTATAAGAGCAGT


ATTACTGGACATCTGTAGTGTAATAGTATTTACCAGACATGACAGGTCCTCTACACACATGATCACACAGCAGCTGTGACTGCATGC


ACCAGACTTGCAGAAGATGAAGCCAGCCAATATCCCAACATAGATGGGAGATGGGCTCATTAAGTCCCATCCACTGGCTGTGGATGA


CAATTGGCAGTGTGACTGCAGGTGGGAAGGAGAGTCATTTCTCTTCATGGATCTGACACCATGCTCCAGTAGATGTGCCCACTGCTG


TGCACCAACAGGTGTCACTCTGTGGATGGGGTGAGTTCACAGCATGTGGAGTTGGGAGGGGGAAATAGTGGAGGGGTGGGGAAAGTC


GCAGATGTGAGGATAAAGTTGGATTTGCTCAAAACACTTCATTTTCATCTATTTCAAGTTTCAAACAACGAAAAAAATAAATTAGAG


GGGATAATACGCAGAACTTTGGTGTAGTGTTTGCTTAGCATGTGCAGAGTCCTGGATAGGTTCCCTAACGCTTCACCTACACCTACA


CATATACACGATATAGCTTTCTAAAATGCATTCCAAATTTGTATCTATTTTAGTATTTTTTTTATTACACTACACGTAAGTATAGTG


CCCATGGAGGCCAGATTCTCTGGACTGGAATTACAGGAGGCTGTGAGCCACCTAATGTGGGTTCTGGAAACCCAACTATGGATGCCT


GGCAGAGCAGCAAATGCTCTTTCTGCTGAGCTCCCTCTCCAACCCCAACCCCAACCCCATTCCCAATTTTAGGATAATTCTTTGAGG


GAAAATATTTATGTACTTCAAAAAAAAGAAAGTATTGAAAGTAGAACTTCCCCCTCCCCCTTTGTGAAGAGAGAAACATCTTGCTTT


TGCAAATGCTGTGTCCTGGGACAGGGTGGGAAGTCACAGTGACTATTCTACAGCCCCCTCCCTCGACTCTTAAGTCGTAGACAGTAG


AGGAAACTTACGGGTGAACAGTGACTGATGTCATTTACAGGTAGACGATGTTTTTTGTCAAACATCCTCCGAGCTTTTAAAAACAAA


CATATACTTTGGTGAATAATGGTAATAAAAAGGAAATTGTAATATGAAATAAATTTGAATGAATGCTCCTTTAGCTCATACAGCCAG


GAAATTTATCAGTAGCAATCGGTATGAGACAAATAGCAAAATGGAATAAATTTGAATAAATTCCTGCCCAGGCAGCCATAGAACATG


TTGATAAATATTTCAGCCTAAACTGATACAAAGTATATCATAAAATATTAACTTTGAAGGAATTTCTGTGTTTTGCATTCAATAATA


TTTCGCCAAATAGCACACACATATCAGGCAATGGGGGTAATAAAACTAATTTTCACTAGGTGGCTCACCCTAGTTGATGATCCTGTC


TCTGCCATTGCCTGTGAGTCACTCACCAAGTAGATTCCAGACATCCTGACCCTGTCCTCTGCGCCTGCCTGTATCATGAACTCTCTT


TCAGACTAAGGAGGCAGCGTGATAAACTAGTGTCTGAGTGGCCTCTTGTTTTTTGGCCCTGCCTCTCTCAGCCAGAGAGACCCAAAG


ATTTCTCCAGCTCTAAAAAGATCCACTAATGATGGAGATAGAAGAACTGACAGGGGGACCAAAGAGGTACTGGTCCCTGTCCCTGGC


AGAGTGTTCAAGTCACTTACGTGTTTTCAGGGTGGAACCACTTTATAAGCATCCATTACAAAACCTTGTCTTTGAGGACTGGCTCCC


ATAGTCTGTTTCCCATGCTGATCTGGATGCTTCTCTTTGCTCATGAGTGGGGACCTGGAGTCTCTTGCTGGGGAGGTAGAAGAGGGT


GCCACGACATGACAAAAGGTAGCATCTCGGATGGTGGTCTTCCTATCTCGGAGCACCGGACAGTGCCTCTCATAAGGACCACATCTT


CCAGCCCAGGGCACCGGAGGTACCCACAGAGGCCAGAAGATGATGTTGGGTTTTCTAAAGCTGGAACTGTGAGCCACATATCGTAGG


TACTTGGAAACGATCTCTGGACCGCTGGAGACCAACAAGTTTTTTAACAGCCACCCCTAAGCCCCATGTTCACGGATCTTCTCTAAG


CTAGAGAGGTTGAAGAGTCAGGTGATTTGGAGCTGGGTAGAATATAGGTTCTCTACTCACTGGATAGGCAGCTGGGATGGCACCTCA


TAAGCTCGCCGTCCCTAATCGGACAGTGGATGGAGTTTACCTCACTTTCAGGAAATATATTTTTCTTTTCTTCTGTGGCACTGGGGA


CCGAACCTGTAGCCTCATGCATGACAGGCAGGTACTCTGCCATTGAGCTATAATCTGGTTCTTTTACTTTTACCTTTTCTCAAGGCT


GGGATTTGAACTTGGGACCTCATGCTTTCTAGGCAAGTGCTCTACCACTGAGCTACAGCCATAGACCTGTGTTTGAGACCAGTGAGA


TGATCAAGCCAGATGTTTAAGTAGACCAGGTCATGATAAATAAGACTAGTGCTATCTTCTTTCTTTTCCCCTCCTTCTCCCCTCCCC


CTCCCCCCTCCCCCTCTCCTCCCTTCATCCTTTCCTTACTATCTTTTTCATTTTTATTTCTAGGGAGTATATTGTTTTTGAACTACA


TGACTGCTTCCTGCAGTTGTTTTGCCTTTTAGAAATAGCTGTGATTGGTTTCAAATTTGAATCTGACCCTCTACTTTGAATGAGACA


GTCTCCAATTTCTTTGACCTTTGAGGGTGGTGGGTACCTGTGTTAATTGAACATATGGGGTTCTCTAGTAGACAGGTAAAAATACTC


GTGTCTTTGGGATCTGGGGCCATGCTCATTATAAGTAAATATTTGGGTACAGGGCAGCTCCGTATCTGTGTGTGTGCTCTCAGTGTG


TGTGTGTGTGTGTTTGTGTAGGGGGGGGTGTAACATTGTAGCATGCTACACCAGTTAAGAATTGCAGTGGTCAGGAGGCTTCTATGA


TTTGGAACTTGGGTGGTAGAGTCAGGCTTTTGGGTCTGGGTCTTGCCGCTGGACTTTACCACTGTGTGACCTACCCCCCCCCATGAC


TGCTGCCAAGACGGAGAGAACTGAACGTTGATTTGCAGCATGCTCACTCTTAAGTGGGTAGCATGCTTCCGTTTCCAGCAGAATGGC


GGACACCCTTGTAGGTAGGCATCGCAGAACTGACCATTAGTCGCCATGCATCTGGTACATAGACGAGGAGAAAGCTTCTTTCTCGTT


CAGACTGGATTACACCCACATCAGCCTGAATCTCACTACCGCTGCCATGCTCAGTCTTCAGATGAATCCAAGACTTGCCCTGTGACT


CCTTGTTTTAATTAGCTGGCTTGGGTTAAGTACAAGGGCTAATTGCTCCAGTCTGGCCCCTGGGTTTGGTTGTTTTGTTCAATTTAC


TTATGTAAGCAGGCGTTCTCTATGCAAACATTTGTGGAAGTCACAATCCCAAAACAGAGTAAATACAGAAGCAGGCTGCACACTGCA


GCAGTGTTTTAGCGACAGTGAGAAAACATCATCTGTTCCTTCTCCTACTTGGGGCTAGCGTGAGCTCTGTTGGTTTGCTAATGTTCT


TTGCAGTTGATTGATGGATTCATCGGGGATTTTGTACCACTCCCTGCATCTGTGCATTTAAGGGCTATTTTATTGACATGTCCACAT


CGTGGCTCTCTTTCTTCTTTGTAAAGAGGTGCCCTGGGCTGGATAGCCGAGAATGTGGGGGATAGGAGAAACAGCTGCTTTTCTGGT


TGGTGGCAGAACTGGTACCCAGCTGGTGTCCTGGCTCCTCTGGCAGTTGGGTATGTGGAAGTGCTGCTTTGACTCTTTAAAGTGTTG


TTTTTGGTAGAAACAGGGGAAAACTGATTCCCTTTTGTTGCTCAGCAGCCTTACCTCCCTCATGCTATTCATCAGAAATAATGACTT


CCAATTTTTTCTCCTTTAAATTAGATACACCATTGTTCCATCATCTATCAATATTTCCTTTACATTTTTTTTTCTGTTGAGAGTGTT


GGCATGTTCCCAGCTATCCTGAGTGCTGGTGTCTGGATTATCAATAGCCCTGGCTTTTCCAGGCTCTGTGTGGCTTACACCCTGACT


CCTCAGGTGTTCCTGGGGTGGGCAGGTTCAGACAGGATGCCCGAGGGTGAGAACAGAGGCTGCACTGAGAGAATCTGGGGAAGGCAG


TGGGTTCCCTCTTTCATCAGGATTTCTGCTTCAGGCTGCCTTTTGCATTTTCACCTATTTTTATATTCTCTTCAAAGCAGTTTTGAA


GTGATAACAGTCATTAACTTCTTTCCTGGCAAATGAACTGAGAGGGGATTTAATGCAGCCAGTGAGAAATGAGAACCTCCCTTCAAA


CCTTTCTGGGGGAGTTGCTAAGAAAGAACAGTTGAACTCCCAAGTTTTTATGTAATTTTGGGGGCGGGGGCTGGGATTTGGAAAGTA


TTAAATTGATCTCATATTCTGAAATTGCGTGATCAAAAGAAACTCAAGAAGAGCAGTCATGTGACGCCGTCAGGTAGCGTTGTCTAC


TTGCATTAGTCCTTTGAAGGTGCAAGATTAAAATTCCTGAAGCCCCAGCTCTGATTACTCCCTAATTTTGTCCTTTTGGCTTTTCTG


AGCTTTGGATTCAGAGACATGGCCTCATTTTGTGGGCTGGTTGTTGGATCAGTCTCGCTGTCGTGGATGTAGTCAGTACTACCTTGA


AGGATGGAGCTTGCAATTAAGCAGAAGCAGCCCAGGGGTGAACCGCTAAGCACTGCAGGTGTCAATGAAGCATAGGGTGGAAGAGAT


GAAAAGCTAAAAGCCCCCCCATGACCTCTTTGCACACCGATTATCCAATCTGAAGTCATTGGTGCCATTTTGCACATAAGGGCCGGG


ATTGCCCTTATGACCACGTCCTTTTCTAGCTAGCTAGGTAACTTCCCTTTTCATTTTTCAAGCCAAGGCCCCTCTGTGCTTCATTGT


AACAGTGAATGGGGAAACATCTTGAAGTAGTCCTTAATCTCCCCACACTCAGTAACATTGTATTCCATTTCATTAAGGATGAAAGCG


CTGGTCCTGACCTATTAAAGGGACAGCAGGGGGGTTGTGACCTGCTATTTGAAAAAGAGTGGTCCAGAGGCTCTCCATCCTCGGTTC


TCAGCATCCTCTGCCCTCCGTGGAGACTTGGCCCCTTCATGAAACCCTCCCTCCTCTCAGCATCTGGTGCCTCCTCTGACCTTATCA


CTTTTCTCAATCTCATTTACAGCATTTACTGCAAATTGGCTCTTATGCTAATTACTGATTTACAACTTATCTCAGTGGCTTGATGGT


GAGTGCCTGGTCAGGGCATGAGCTCCGTGCTGACCTCATCCATCAACACACACACACACACACACACACACACGCGCGCGCGCGCCC


CAGAGTGTCCTGGCCACCTGAGCCCTTGCAAAGTGTGCAGTGCTTGGATGCGCCTCTAGCTCAGTGCTGACACTTGAAAGCCAGGAC


ATCACACTGCCACTGTTACAGCTCCAGGGGCATGGCTATCAGCTGGGCTGCCTTGATTTGTTACATATCTGAAAAAGAATGAGATTA


GGTTGGGGTTGCAGGTCTTTAAACCTTTGACCTTTGCAGTGTAACAGGTAATTACTTCAGCCTACAAGGCCTGCCTTTTACAGCATG


AAGTGACTTTTCATGTGTTTTGTGATGATTTGTGGATCCTTGACGGGATGGTATGCAGATGGGGCGTTTTACTTATTTATATTGGAG


CCATTTGTCTACAATGTGGAAACCTCACACAGAGGAGAAGGAATACAGATACCTTAATCATACGCCGTCTCTCACATCTGGAGCTCA


GTTTTGTGCTTCTAATGATGGCGTTCAGAGAAGAGCAGGACCCATTTTACGTTGACACAAATTATCTACCCAAAGGCTGACCTTATT


TAAAGGAAGTGATTCAATTTAGAAAGGTTGTCCCCATTCAATCTAATTTCAGAAACTTGACTGTTAAAACCTGTCCCTATACCATCT


TGACTAACAGATGTAGCCATAGCCCCATCCATCTTGGGGAAGTGCCTGATTAAAATATATACCATCCCTGGACTTCCCAGACTCTAT


ACATTTGAGAAAGAAATGTATGCTGTTTATAACGTTCTTAAAAACGGTCTGCTAGAAATACCTAGGAAGTCACTGCTGAAGAAAGAG


CTAGTCAGTGATGCGTACTTTTAGGGGCTGGGCAGTTTGCATTATTCACAGTGGATTTCAGTAGGACATTTTCATACATGAGTGTTT


CTTCATGTTCACTCTCTCTCTCCTACCCCAGCTACTCCTCTGAACTCTTCCCAACTGCCCCCTCCCAATAACTTTCATCTCTCTCCC


TTTCCTGGCAATCATCAACTATGCACAAACGGTTCGTGCTTCTTATAATGGCTTCTTTTCTGGGCTTGGTGGACATCTCAGCATATT


TAGCAAATCTGCTCATACATAGGCAGATTTCGCTTTTGAGCATCAAACCCTCACGGAGACTTTGAACTGGGTTTAGTTTAATTCTGC


ACTCAGCGAATTTGCAGACAACTTGCCTTATTTGGACTCCTTCCCACCCCGCCTGCCACTTACCCAAGCTAAAATGTATGTCAAAGG


AAGCGGGGCTCATCTTAAAGGAGATTTGGAGAAAATCTTCCTTCAATATTTAAAGTGCTTGACAAAGTCATGTTCACATGGAAGTTG


GTTTTAAGATCAGGAAGTTAAAATCGGGCGGCTTATTTACATTACTGTCAGAAAGCTGTTCTAATAGGATTGACATGGGGCACTAAT


TAATCACCCAGGGTCTCTCCATTCACTAATCATATTGCGTGAAACTTCCCTGCTGGCCGAGGCTCAAGGGCAAACCTTGGGCTACCC


GCCAGCTTATTTTTCATAGGCATTATGCTACTGCTATGAATTAATGCAAGCCTAATGTATTCTGTCAGTGGTTTATTCTCCCATGGC


GATCTTCTCTGGTTAAACAGCTTTAAATGAAATTTTATATTAAGTATGAAAAGAACTTTTCTTTCAGATGAGGGAAAGGGGATTAAA


AAAATCATCTTTGTAATCTTTTTCCCCCACAGTCTATACTCTTTCAGTTCTGGTAAAAATCTGCTAGATTAATTGAATAAGGCACAG


ATGACATGTTAGTTTCTTGCCATTACCTGAGAAGTGACCTTATATTAAGCCTAGGAAACGTTCCCTATTACATTTTAATTGCAGCAG


CAATGTGTGCTTATTAAGTATCTACTGCACACAAAACGTCTCAGCCACTTCTTCTTATGTCTGCCTTTGCAAATACAGTAACTGTAT


CAATGCGAACCCTAGTCTGTTAGGCTGCCTAGGGTCACATTTGGTAAATGCTGGAGCCAGGTTTGAACCAGAGCTTGTCCATTCAAG


TTCTCCCTTATCGGGCCATGTTACTGTTTATCATTTGTACAGTTCCCCCATACTGTCATTTTACCTTGGGACGGTCCAGTGGTCTTA


ATCTTCAATAATGAAATGTCTATTTCCACATTGACTCATTACATTCATCTGAGTCATTTCTGAGGCATGTTGGTTTGGGGTACATAA


TTTCATCTCTCACTTCACCCTCACGGTGCCTTATTCAGAGAACAAGAAGTTAGCGGCATCTTTGAACCAGAAATAAACATAGCTTAT


TCATCTCCCTCATGCTGTTCTTCATCGCTCTCAAGAAGAAGAAAAAAATCCTAATAGAAAAGGAAAATTCCAGAGTGTATTCACATG


GAGCGCTCCCAAGGCAGTGCCTGCCGAGAGCTCAGCTTCCCATCTTCAAGCTGCCTGTGCAATGGCGACAGCTTGTCCTGTATGCAA


ATGAATTCCCAAGAGGCTGGGAAATAAACTCTTACATAAAAGAACATATAAATGGCTGACGTGTCAAAACCCATTCCTTAAGAGAGC


AGGACGGTACTTGGTGGCACAAGCGGGGTTTCCCCGTGAAGCTCGCTCTCCTTAGTATGCTGAGCTGATGTTCTTGGCTGAAAGAGA


TCCATCCCGTTTCTTTTTATAGTGAGCGTCATGAAAAGTTGGAAAGGGGGAAAAACTGTGCTGAACATACAGAATAAATAAGTAACT


GCTGCAGGCCAGGCAGGCTGCCTTTTGTTTTCAGACATCCACTCCTTCCCCCTTTGTCCATCACGGATGCCTGGTGTATAGAGCGCT


TCTTATGGAGGTTGTTTGTCATCCACAACAAAGGGCTAATTGCGTCTGGGCCTCCTTTCACATGATAATCAATGGATCTAGATCTCC


TCTCCCTATCTTATGTTCATCTCGTCCTTATTTATTTATTTTAGGTTTTGATTGAATGTAAAGGATCAGAGAGATGACGCCCACCTA


GTAAACGCATGAAGGGAATTTTAAACGTGGGCACGGAAAGGAAGGCACCTGCTACCACTTTTCTTGTGATTGATTTGAACAGAATTA


TAACTTAGAATAGCTGTTGAAAAGACTCCGTGGTGTTCCTAGGCACTGATGCTCTTCTCTGAGGACCATTTCAAAAAGGCCCTCTGT


GAGGAAACTCAGTCCCTGTTAGAAGAGGGACCCAAGGTGCTTTGAGGCTACTTGGGGTGCTCTATGTACATTCATTTCTGAAGTGTT


CTAATTTTATTCTAATTCTAATGAGAAGTGAGTCTGTGTTCAACATGGGTTTCTTTTTGTAGCTTTGCCAGAACATACCATTGTGTA


TGTGTGAGGCATGTATGTGGCTTTACGTTTGAGTGTCAGAGTAAGCTAACTAGATGAAAATCTCTCCATCTACGGAGCTTATGCTAC


CATAAGTGCCCCCATTTTGTGTATTTGGAAACTAAGGAACAGGAGGTTGAATTACTTGACCAGGCTCACATGTTTGTGACTCAGACC


TAACTCAAGATAGAAAGACAGGGAAATATTTGGAGATCCCGACAAGGGAAAACAACACTTCTCCACCAGGAGTCTAGTTGATGCCAG


CCACCCAGCGGCATCAAAGCAAGAATTTCAGAGCTATTAATAACTGCCTAAGGCCTTCCTCCCTTCTCAGCTATAAACCTACAGTTT


GCTAGGAATTTCCCCAGGAACCCCGTTTACAGGGAAAGGACGGATACTAACTTACTACCCTTGTGTAACCCTAGTAACTTCTGGGTT


ATCATATTATAACCCAGCCAAGGCATCTCCAGAGCCTCCCTATAATCTCACATGTCAAAAGAATGAAGGGAGAAGAAGGCATCTTCT


TAGCAGTCTTTTGAGATGTAATTTGAGAGCCACCAAAATGGTATATATGGCTGATATCAAGACAATTGTGACTTTCCCTTGAAAAGC


TCAGCACACACACACACACACACACACACACACACACACATATATTTTTCTTCCTTTGTGACTCTTAATGAATCCCAGTCATGCACT


TGGGTCTGTCTTATTTTCCTGTGAGCTCCCCCCTTTCTTTTAATCTTTATTTTAGAGCCCATTTTAAAATAATCCAATTTTACTTTA


TGAACTGATAGTCCTGAAATTCTTTTCTGCCTTGAAGCCAAACTTGAGGCCCATGGAAAGAGTCTCCAGACCATGAGTATGGTGACG


TGGAACTCTGTCTCAATCCCCTTCACCACCGACAAACCTAGGCCCATTTACCTAAGGGTCCATAGCTGTCACCGTTCACCCTTCTGC


TTGTTGTCACAAAGTCCTCTGGCCTTATGGCTTCTCATAGTCTTCGCGCAGATTTTCCTGCTCCTTCCCGCTTTGGCTGGTGTCTTT


CTCACCAGGATGGCTGCAATGGCCTCCCAGCTAGCCTAACTACTAACAGCTTGGCCTCTTTCCCTTTGTTCTCTGTACTGTAGTGAA


TAAGTTGTCCAAGCTGCAAACCTAGCCCCCCCCCCCCCCCCGTCCTGCTTGGAGCTCTAACTTGGTCTCCCATGGCTTGGTGGTCCC


TGGGTGTACACACCACACATGGTGTGCTAACCATGCCCTAGCtTAACCCTCTGGCCTCTAGGTTCTCAAGCTTAAAACATCACCTGC


CTGGGATTGAAGAGATGGCTCAGCTGTTAACAGCACCTCTTGTTCTTACAGAAGACTCAGGTTTGCTTTCCAGTATCTTCCTAGTAC


CTTGTAACCCAGTTCTAGGTGCCTCCTTCTGTCCTTTCTGGACACAAGGCACACATATGACACGCTCGTACCTGTAGGCAAAGCACT


CATTCACATAAAATAAAAACCAACCTTTTTCTTTAAAAAAGCCACGCATCTCGGTGACTGTGCAGGCAGGTTACGGAGAGAGCTGGC


TGCCTTCAGCCAGTTTTCATGGGGCGGGATGAGGGATGCCTGAGATGGTGCATTTCTGATAAGTCCCCTGGTGCAGAGCCATCCTGT


GAGGACCACTGCTGGCCTGAGCCTTGTCGCACGCACGCATACTTGCAGACCCCTCAAGGGACCCACCATGCCACACTTTGATCCTTC


TGCATCTACTGTTGCCTGTGCAGGAGTGAGGCTCCCTTTGTCTCCCCTTTCAAACACAGCTAGAATGTTGCTTCCTAGGAAGTTTCC


TCTGTCAGCACCCCCACCCCAATGCCTCTGTTTCTATGGCAACTTGTCTATGCCTCCAGGAAGACTCCATTCCCTGCACCTAAGTTG


TGATTTTATTTATGTGCCCCCATTAGCTCTCTAATAAAAGACATCATCTGTTGTTGTTTTTTTCCCTTTTGGGGGAGGGGCGGGCAA


GGAGGATGGCATTCAAGACAGGGTTTCCCTGTATAGCCTTGGCTGTTCTGGAACTGGCATTGTAGACCAGGTTGGCCTGGAACTCAG


AGATTCATCTGCCCCTGCCTCTAAGTGCTGGAATTAAAGGTGTGTGCCACCCCTGCCCGGCTTTCTCATTCTCCTTTCTATCCCTGG


CACCTAGCTCCGTGCCTGCTCAGTCCTGAACATATGAAACATGTTGTATGATTTAATCCTTCTTCCACCATTACAAAGAAAAATCCT


ATTTTGAATTGTATTTGTGTTAACTATTTGTTTGTTTGTTTTAGCTCTTAAAACATGTCTGTGGTATTTTGCTTTTAAGTTAACAAG


ATCTTTGAGTACAAAAGCTGTGCATCTAAGAGTACTAAACTTCTAGACCCAGTTGGTGAGTGCTCTGCATCTTGCTGCTTAACTCAA


ACAGTGAGAGCCTCTTCCCACAGAGGTTCATGCTTGCCTACAGATAACTGACTTTTTACGCCTGTAGTCTGACATACTTCCAGTCCA


TTTCAGCCTTCAGTGCGCCCCTCTGGTGTGTTTTCAGCCTTGGCTTTGTCTAATGGCTGGGGGAGGGGTAAGCAATAGAGCAGCCCA


TCAGGGCAAGCCTTTTTTAAATTTTATTTATTTATTTTTTTAACTGTAAGACAAGCAAAGATTAGTGAGCTGTAAGCTTGCAACTTC


CACGTTTCTATCCAGAAGTGGATAGCTAATCCCTCATGTTCCTTTTTTATATGCTTGCATTGCCTGGGTAATTTCCAAGAATATGGA


TTTTATTGCTTGCGTAGCCGTCCCCCTCCCCATCTCAGATTACAAGCTCTTGCTCAAAATGTCAAGGTCCAAGTTCTAACAAAGAGC


TCTCTAGACCAGACTGCCTCAGACTGTGGGCATTTCTTTAAGGCCTTCTCCTGGAACAGTGTGCATTCAAAGGGAAAAGCCCTTTCA


TCGTCTCTGGGAAGATACTGCGGGCTCTTGGTGCTACGCAGTTCCAAAGAAGTCCCCCTCCTGGCCCCTTTTTCCTTTCCCAGGCTC


TGTGTGATGGACTGCTCCAGATCCTGTTCTTGGCTTCGAGCCCCAGCAGTCTGTGTCCGCAATCCCATAAACAAGCAGAGGACTAGC


CCTTCAGGTGGATGGTGGAGACTGAATTAAGTATTCTTGCCTCTCGTGCCCGGTCACAACAGCTGGCCCAACAGTTTAGAACATCTG


GGGTTTTCATTGAGCTGCCCTGAAAAGAGATCACAGCTTCGTACAAGTCAGAGGAAGCCCCCAGCACTGTGGTTGTAGGCTTCTCTG


AATGTTTTGCTCATGCAGCATGAGAATTATGTGGATCCCCTAAAACTGTGGGTGTAGGTATTTTATAGCCATTCATGTAAAGGAGCA


GAATAGATCTCAAACTAGAGTCCGTTAGTGTCTCTTAAATATATAACTATTTGGAGCACAGTTCTGGAAGGATGCTCAAGCCGGTGA


CAGAAGAAGGAGAATTAAACAGCACTCAGGGGCCGTCCGTCACCTTTGCTTTATCCATGCACGTGCTCAGTGATTAGTATAGGCCCT


GACTGTCCTACTGTCTGACGTGAGGTGTTGTCATTCTTTCCAGTCCTGTGTACACATGTAGGCAGGACAAGGCCATACCTGGTATGG


CAGGGAAGCTCTGAGGACAAGGGGGCCTGAGTTCATCTTCTACCAGGGCTTTTCTGACTCTGAAAGCGGAGCTGCCTGTTAAGGTGG


CCACTGTGGGAGGAGTTGGGGAGCAGGCAGGGTAATGTCTGAGGAGCGATGGGGGGCAGGGAATAATCTGCACAGACTCCTTGCTTA


CAGTTGGCTTTCATGTGGTTTCGTGGACCCCACAGTTTGCAGCAGTTAGTAACATCAGTCATTGGTTAGATCAGGCAAGGCCTGCAG


GCTCTGGGAAGCCAAAGAACCCTTCAGGGATTCCTGCCCCATCTGAGGACACAGTGTAGTCTTCTCAGTGGCCTGTGCAGCCTGACA


CAGCCTGGCTACTGTGAGCCTCTGAGCTGTGCTTCTCCGTTCCTGGCACTTTGTGTCCCGCTTTGTCGCCATCTGTCCGGGGCCTCA


GTCCAGATGTCTGGCTTCGGCTAGGGTGCTGTTCGGACATCCGCCAGTCAGCTCTTCCTTCCTTCATGGTGCCCAATGAACATGTAT


TTTTTTCCCCTTAATATTTATTTTGTTTTTATTTATGTGTCTCTCTGTGTGTATGCTCCAAAGAGGATGTTTAATCCCCTCAACTAG


TGGGGCTTGAACTACTGGTTGTGAGCTGCCCAACAGGGGGTACTCAGACCCCATGTCTAGTCCTCTGTAACAGCAGCAAACTCTTAA


CTAATGGAGTCATCAGATACTAATCCCTGTCCCTCTCGTGGGTTTGCTCTAGTCACTCTGCAGTACCTGCAGTTGCCTTCCACTTGG


CTTTCTCTCCTCACTCTGCCCTCCTCCCTGGCAGCAGCCCTGAGCAGCCCGCTCATCTGTGACTTTCTATTGCTTGTCTTTCCTTGC


GCTGCCCTGCTAGCGTGTCAGTGCTACAAAGCAGGCACTTGTCCGCTCAGTTCCCTGACTTGTCCGAAGCCCTCCAGTGGCTGCATT


GCCGGTTGTAGTTGCCCAGCAGGCTCTGCCTTTCCCGAGTTGTATTATGGTACTGTGCAGCACCAGGGCTAGAGGTCCCTAGGCAAT


ATGTACTGGGGCCACAATTAGATGGCCTTGTGACTATGTAAAGGGAGAGACATTGGCCCTCGCCTCCATGGGAATTGTCCTGTTTAC


AGACTCGAGTTTTGTCTGTCATGCCATCTTATCAAGACCATTCTGGACAGTTGTAAACTGGGACATCAGAGCCCAGTGGCAAGAGTA


GGATTGATTCTCTGTTGGTTGAATTTTCTGCCAGCTCATACTTTGGCAGGAATTGTACTCAGGGACTTTTTTTCTCCTGAAATAACT


CCCCACCCTACCAAGACAGGTGTTGTATTAGTGGCTGTACATAGGATACCTGTATAAGCTGGCTACCCATCTGCCAGAGCTGCAGTG


TTGGCTCAGAAAAAAGGAGAGTGAGAACAAGTGAGCTTCTCTGCTGGCTCATTGGTCTGTCCAGGGAAGGCGGTAGGTGCGCCTCGC


CTGCCTGTTCCAGCGGAGGTTTACATTCTCAGAACGTTAGTCCGCTGTTGGTGAGGCTGTTGGTGAGGCTCGGCTTCCTGCAGTGCT


GGTCGGGAACTTTGTTTCAGTCTGGACAGATCGCAGGTGAAATTGCTACATCTTAAGCAAACAGGAGTAAGGAGTGCTCGTTTAGAA


GCCGCTTAAGAACTTGGATGGCTGGGCCCTGGTATGTAATTGCTTCTTTTTAGGAATACAAGTAGCAGAGGTGACAGAAATATATGA


TGATGGTAAAATAATTTAGTTTTCAAAAATACAAAACGTGAGATTTGCTTCCCAGAGAATTCAGTTAGCAGCCAAATACTCAAACAA


GAAAAACATCCTTCAGAATTTCTGCTAGGTCCAGCCAGCCCTGAGAACAGCACCCAGAAGTCGATTCTGTCTGCAGAGCAGTAGGTT


TTATTTCCCCTGTACTGGGAAGTTGAAGACGGGGCCCAGTGTGTGCTTGGAAAGCACTAACCACTGAGCAGCAACCCAGACCCACAT


TGGAATGTTGAAGGGCCATAGTTTCCAGGTATAAGACCAATTACCCTTCACACCTCCATCCTGTCATTACCGGAAAACACTTCTCAG


TAGTTCTCAGTTCTGCCCACGTTTCCTCCATATCCTGGACACGATCAGCTCCTGCCTGCTCCTCCCTCATCTTCCTTTGGATCCCTG


TGGATCCAGACGTCTGCAACCCACATGGTGATTCTTCTCCTCAGTGCCAGCCTGTCCCACCCACTCCCACCCACCACTCAGTCTCAC


AGATGGTCCCTGAGAATCCTCCTGTCACCAGGGTGATGAATGGGCGCCTTACAAGGTCCAAAAGTGCCGTGCCACACTTGCGTCTCT


GATTGCATGCCAGCCCCTCCCATCTGCTGTTGTTAGCCACACAGATTTGGTGACTTGTAATTCTCTCCTTACCACGGGGCAGTTTTA


TTCTTTCGTGACCTGAAGTCCTCTGAACTGTAAGAGCTATGTCTGTTTTTTCTTATCTCCTTTTATCTTGAGACGTGTAAGGTCAAA


GTATAAAGTTGGGACTCAAAGCGACTTGGAATACTGGAAAGGTGGCTTTTTGAAGTGTCCATTTCGTGCCAGTTGGGATGGGACACT


GTTCCAGTCCAAAACAATGGAGTCTGCCAGGATGAAAATAACTGGATATGGAAGAAGAGCTTTTCCACTTGACAGTGGGGCAGATGC


ATCCTTCTGGAATCACCCTGTGACACCCGAGACTATTTTCCTTTCCAGTTTTGCCAAAGCATCAGTTCTGCTGGCTCTGGAATCCAG


GTCTAGCTTCCGTCACTGTACCACTCTTGGTTCCCATGGGGCCATTCTCAGTTCTGGCAGAAGAATGCACCTTGGATGCCTAGACAT


CAGAGGAGCAACTTAGAGTATTAGGGCAAGCACTTCCCAGTGTTTCCACTGTGAGCTGGTCTATATAGAGAGGGCGTTTTAGACATT


AGGGGACACACAGGATGAGCATGCTCAATCTGAAAAACCATAGGTTTGTAAGTACCGCTCTAATGGCTGAAAGGTTTTGGATTTTCA


TGCTAAAGCTGTTTAACTGTAGTAACCAGCAAAGTCTATGCAAATATACCCCAATTCAGTAAACTCTGAAATATGAAATACTCCGTC


CGGTTCCAAGCATTTTAGTAAGGGTAATATGCAGGGCTGGAGAGATGGCTCAGTGGTTAAGAGGGGCTGGAGAGATGGCTCAGTGGT


TAGGAGCTCTGGCTGCTCTTCCAGAGGACGTGGGTTCAGTTGCCATGTATACATCCATGTGGCAGTATATATCTATAACTCAGTTCC


AGAGGATTGGATGATCTCTTCTGGCTTGTATGGGCACTGCAAGCAAAATGCCCACACACATAAAAATAAGTAAAATATTTTAAAAAA


ATCTTTTAAAAGGGAATATTCAGTAGTACCTATTCCCTGAGTGACACAACTCAAGCACAGGCCTGTGCACTGCTGGGAGAAACATTG


TTTCTAAATGTATTCTGCTATCTGTTAAATAAGAGTGATGTCAAGTATCTATCTACTGCATGGAATTGCTGTGGGATACTTCAGGTG


AACATTATTCTGCACAGATGCAATTTAATGCAGGCTTATATTTTCCAGGAGTTATGCTTTAAAAAAAGATAAAATTAATTATAAGTT


GAAATTTGCCAAATAAAATCTTAACATTTCAAAGCAGAATAATAACGAAGCACCAGCTAATGGAAATGGCCTATATCCTTTTCATTC


CTCCTAGCTCTCGGAACCTGGCTGGTGCGCATGGAACAAGCGCTTGCCTTTGCACCTCAGTATGAGCTTGTTGCCTACCAGGTGATC


ACTGGCTACCACACTGTTAGTACTGGTTTTGGAATGGGGCCAGACATGGTGGCACATGCCTTTAGTTCCAGTACTTGGGAGGTAGAG


GCAGATAAACCTTTGTGAATTTAAGGCCAGCCTAAGTCTGCAAAGCAAGTTCCAGGCCAACCAGGAGATGAGACCTGGTGAGATATG


TCTCAAAACAACAAGTGTCCTTAGTAGGACCTTCTTGCTGGAGATGACTTTGCTTGCAGGACTCAGAAACCAAACTGGAACTGACCT


GGAATCGTCTTTACTCATTAATGCTTGGCTTTCATAGTGACCAAAGTACTAGCTGGGCTGCTGGGAGGAAAAGGCATCCATGAGCTT


ACCCAGTGGTGAGCCCTGCATGCTGCAGTACCAACCTTAGAGGGAAAACGTGCCAGCCAGAAGTCATGGCTTGTCAAAGGCCAGTGG


CTGACATGGTCGCAGGTCCTTGGAGGCAACGTGCTCCTGTTGTTCTGGGAAACGGACATGTTACCAGGTTTTCTTGTAAATATGTGT


TTTTATTCCACTAGGTTAGTGTTACTCTCAGTCTTGATCTTTTTGTATTAAGCGATGGTCAGTAAAAATTCTTATTTTTAGTCAGGC


GGTGGTGGTGCACACCTTTAATTCCAGCACTTGGGAGGCAGAGGCAGGTGGATTTCTGAGTTCCAGGACAGCCAGGGTTATACAGAG


AAACCCTGTCTTGAAAATCAAAAACAAAACAAACAAACAAAAAAAGATTCTTATTTTTTTTGAGAGAATGTTTTATTTATTTTTGAA


TTATTTATTCATTTTATGTATATGAGTACACTGTAGCTGTCTTCAGACACACTAGAAGAGGGCATCAGATCCCATTAGAGATGGTTG


TGAGCCACCACGTGGTTGCTGGAATTGAACTCAGGACCTCTGAAAGAGTAGTCAGTGCTCTTAACCAATGAGCCATCTCTTCAAGTC


CCAGTGGCAGCAGTGGTTATCTGCTTAACACGTACACAAGATCGTGCCAGTCTTATAATTACAGCAGGGGGGAGGGGAGGGGTGGGG


AAGGGGCTCATGATGATCCACCCCTACCTGAGGGCTGTTGGCTTAGGAGGAGTCAGTTTGTCTTTGGGAATGTGGCCCATCCTCAGG


CATACAGCACTAACTGGACTCACTGAGGTAATTGTTAGTGAAAGAAAGAGAGAGGACGTGGACATGAGGGGGACATATGTTTGGGGA


GCCTGTGGGAGAAAGAGGGAGGTTCCTCATGGATACAGATCATTGTATAAATGTATGATAATTTAAAAATTTAGTATCTTGGGGCTG


AGAGTATAGCTTAGTGATAGACACCTGCTTAGCTGTTTAAGAGGCCCAGAACTGGCCCTAGTACCAAAACCAGAAATGAAAATAGCG


ACTTAGCTCATATTTAGCATCCAACTAAAGTATTGTTACTCATTTTACAACTTCAACACTTTGATGGACAGACATTCGTGCCAACAT


TTGCATACACTGCTGTGTGGGAAGAACGTGGGGTTCGGTTTTGATTCTATCTCAGTAGAGTAACTGGTCACCATGACGAGTTCCCAG


CGTTCCTCTGCACCCCTCCCCACTGGGTTTCACAGTGAGGTCACTGTGGGGTTTCTGGGCATCTTTCCTTTGGGAAGGGGAAACTGC


TTCAAGTGCTGCGTGCCTGTCTCTGGGTTTTGGCTCTTCACTGTTAATTATTTGGAGCTGGAACAACTTGATTTTAAAACAAAACAT


ATGGGCTGAGAGCAGTCGGGAATACATTTGCTGCTGATGTAGTGCGGAAGCTATGCAGCAAGCCGAGGTCCCGCCCTGTTCTAGTTA


CTCGCATAGGTATGGAATGGTTCCCGTAAATTTCAAGTCATGCCCCTTTCTCCAAATTCTTAAACTCCCTTTCGGAAAGACACAAGT


CAAAGCAGGAAACACTGAAGCAGATTGTAAAGAAAATTGTGAATCTCTCCTCTCTCCCCCAACCCCTACTTTCCTCTTTCTCCTCTG


TGGAAAACCTTATCTTTTCAATTTTTTAATTCTGATTCTTAAAGTTTTTTTTTTTTTTTTTTCCCCAAAGTGCCAAGAGGAGAAAGG


AGAACTGTGTATATGTAAAGGGAAGAAAGCCCTCTCCACACCCCCAGCCAAATTTCTCACTTTCTCCCTGGTCAACACTAGAACGGA


GAATGTCCCTTTCACGATCAGCACTAAAGCGAAGGCGACATTTTGTCCCTTTCTTGAGATAGTCTCTTGTAGCCAAAGCTGTACTGG


AATTCCAGATCCTCTTGTGTCTTTGGGTTGAGGTTGTAGGTAGGCACCCATCTCTTACTTCACCTTCTCTGCTTGCTGCCGTCAAGC


CATGCCGTGTCCTGGTCATGTCTCACAGAATTCTGGCTCAAATGCCATCCCTTTGCCATCCCGGGTTGGGGGTGGAAATTCATCAGT


GAGGACTCTTGCTTGCCCTTTATCAGATCTCCATTCCTCCTCATAGCACCTGTGAGTTCTACAGAAGAACCTACCCATAGTTATGTC


CCCCTTTGCTAAAAAGGAGGCCATCACAGTGCCAGTTTCAAAGTCAAACTCTACTGTGAGGCTCAGAGAAGACACTCCCTCCCACTC


AGGAAGCAGAGAGCCCGGCAAATATGGAAAGCAGAGTTGCAGGAGCGACTGGCAGGGACAGGCATGCACCCAGCCTGCTCAGCAGCA


GTGAGACAGGGACTTGACCATGATACCATCTGTTCCATCCCATCCACTGCCAACAGTGATACCGTGGCTGAACTCTGTGTCAGGAGC


CGTGACTGTTGTCCACAGAGAGCTTTAGCCTTAGAAGGTCGGACATTTCCCCCTGGGGTGCATTTGATTTTAGTTGCATGCAGCAAA


GCCTGAACTCTGCCCTATAGAGCGTCCCTCATCTGACAGAGTCCTGTGTATTCTCTTCTGTCTGTCAGCTATGACTGTATTTTGTCT


AGAACCTATAAATACAGTACTAATACGCCAGGTTGCTTGGTTCCTGGACCTTTTTCTTGTTTTATATCAGGAACATAGCACACTGAC


CAAGGAAGTAGAAGGGCTGACCATAGTTTTTTCATAGGCATTGAAAACGAGAAATCTTTTTTTTTTTTCCTCCAAGACAGATTTTCT


CTGTATAGCCCTGGCTGTCCTGGAACTCACTCTATAGACCAGACTGGCCTGGCCTCAAACTCAGAAATCCGCCTGCCTCTGTCTCCT


GAGTGCTGGGATTACAGGCTTGCGTCACCACGCCCAGCCCTCTTTTTCTTCTTTTAAAAAGATTTATTTATCTTACACTGTACACTG


TTGCTGTCAGACAGACCAGAAGATGGCATCAGATCCCATTACATATGGTTGTAAGCCACCATGTAGTTGCTGGGAATTGAACTCAGG


ACCTCTGGAAGAGCAGTCAGTGCTCTTAACCTCTGAGCCATCTCTCAGCCCCACAAGAAATCTTTCTAAGCACGTATGCTGGCAGGT


TTTATGTCAGCTTGATATAAGCTAGAGCCATTTGGGACTGGGGACTCTGGGACTCTGTGTCTACACGTTTGGTCTGTGGGCAAACTT


AGGCAGACAAGTCTGGGGAGGCATTTCCTTAATTAATGATTGCTGTGGGAGGGTCCAGCTCACTGTGGGTGGTGCTGCCTCTGGGCA


GGTGATGGTCCTAGGTTGTATAAAGAGGAGCAGACAAAGCATCCCTCCTTGGCCTCTGCATCAGTTCCTGCCCTGAGTTCCTGCCCT


GTCTTCAGTGATGGGCTGTGATGTGGAAGTGGCAGGGAAATAAACCCTCACTCCCCGGGTTATTTTTCCTCACTGTGTTCTGTCACA


GCAATAGTAAACTAACCGTGACAGAACTTTTAAAGTAGCTCCCTTGGAGCAAGGGTAGGGAACATAGAGGCTTATTTTTTTTTCCTT


TCTCTCTCAAACTGAAGACATACTGAAGGTTTCTGTGGGTACTTAAAGTATTTTGTACTTTATCTTATTTTTTTATTATTTTTGTTT


GTTTGTTTGGTTTTTGGTTTTTGTTTTTTCGAGACAGGGTTTCTCTGTACAGCCCTCGCTGTCCTGGAACTCACTATGTAGACCAGG


CTGGCCTCGAATTCAGAAATCTGCCTGCCTCTGCCTCCCAAGTGCTGGGAATAAAGGTGTGCGCCACCATGCCCGGCTTTATTTTAT


TATTATTATTATTATTATTGAGCTCTGGGAATTTTTATTCTTATAAATAGGACCATATTTCTGAGTGACTGATCTTGTACTGTCTCC


ATTTGGATTTCTTGTCCCCTGCCTCTAAAGTGTCAGAACTCCCTCCTATGAATGGCAAGATCTTGCTGAGTGGACAGCATCCTCAGA


CTCCCCTGAAGCTGGGGAGTAACCACCCCTCACTGCTGTGCTCTTCAGACACCCTCTCAGCAGAGAGGTCTTCTGACATTTAACTTA


ATCAAGATGTTAGTAAAATAAACAGTGTTCTTACACCGTCGGACGGAAACCGCTTGTCACCCCACCCCCACCCACCACTTCAGTGTT


TGGAAAGGAAACTCGGAGTCGCTCTGAGTCCAGTCACGCTCAGTCCTGGCCCTGGTTTCTTCCTGGGTGGGCAGCACTGTCTGCTTG


CCACCCAATCTTCAGTGGCCCAGTTAGGAGTTTTCAGTACTGTCGGGGGGGCGGGGGGGATGATACCATGCCTTTTAAACCACATTT


CAGTTTCGGGGATGTTAAAATGTAAAGGGGGAAAAGTGTGTCTCAGAGCAGACAGGGTCTAGTGAGAACCAATTAAAGTTGGAAGCC


CATCCAGTCCCGTTGCTGTTTGCATCATGACCGCCCCTCCCCCCATCCTCAGTGCGGCTGACAGCGCCTCAAGGAAGTCTGCCTTCA


TTCACTGTGCATGTCATGTGTGTGCCAAGTTTTACATGGAGCTGTGGGACATGCTGTAGACTAGGAAGAGTAATGGGGCCCTCGGAA


CCACAGTTTTAGTGTCTTTAAAAAAAAAAACAGTCTGAGGATTATTTGGGTCACGTGGATCACAGGGAGCATAGGATTCTCGCTGCC


TTTGAAAGAGTGACGAAGGGTTGGTCAGAGGACATGGGGCTCCTGTGTTCTCTCTCTTACCTGGTCCACTCGAAATGGTTCAGTGGG


ACAGAGATCGCTGCCTCACTAATGTGTGCCCTAAATGTTCACATCTAATGAACAGTGTCGTAGGTACTTGGACTCAGCCACTCCACT


CTGAATATTAGTTCATCTCATTCAAGAGTCTACCTAAAGATTATAAGTCACCATTTGAATGACTTTCAGGGTTCCTACCCCATCTCA


ATGTTACAATATTTTAAGCATGTTGGCAGTGGTAGTTCTTTTCCTCGTTAACGCAGATGTTAAAGAAAGCTTTTTTGGTTTGTTTGG


TTTGTTTTTTTTTTTTTTTTTGTCTTGTTTTTCTGATCAAGTAATGTAATTAGACAACCAATTGAAACCATATTTTCGAGAGTAAAC


ACATGGTGCTTTCTCCCTAACGCTGACCCCGTCTCCTCTTCTCTTTCAGTTTTTGGGAATAACGTTTCTTGGAATCGGACTGTGGGC


GTGGAATGAAAAAGTAAGTGGAACTCCTCGGAGAGGAACAGGTTTGGTTCAAGGCCGTGTCTGGTCTCGAGTGTTTCCCCTTGCTCT


TTGATCAGCACAGGGGACAAACAAACCGTTGTCTGATGAGAGGAAGCATTCTTCACGACTGGGTGTCTCAAGTGCTCACGACATTAA


AATAATCAGCAGAGCCACAGTGTAGTGAGTGTGGACCGCGGAGGATGTGACTGGGGTTTGAGTCCAAGGCACAGCTCCACCCAGCCA


CCATGACCTCAGTCGGCTTATAAATGTCACCACGTGACCTGTAACCTTTCATCTCCCTCTCTCGTCTTTTGAATCCTTTTGGAAGAT


GACTTAAATGATAAAAAATGGCTTTTCAGTAGGCCGTGTGGTGGGATGGAAGCCAAATATAAACTTATGTGTAGATATCAGATAAAT


TCATCACCAATGCTGAGGGACATGAACAGGCAGCCACTGGTCATAAATATCAAGAAATGCTCTGAGTCCGTGGTCAGGGATTGCATT


GAAAAAGGAAAATCTAGGCATATCACGTTACATATTCCTAGTCTCAGTGATGACTGGGTTCTGGGCAGTTCCTGTCCTAAGCGGTGC


TCCCAGCTGCATGTTTTGATTTTTCTCTGAATTTCCCAGTTTACCACCGATATCCAAAAGTGGGAATCACCCCCTCTCTCCTCCCTG


TTAGGGGGTGAAATCACTCAAAGCATGTTTTGGCTACACAGTGCTCTTACCTTGTGAGAGTGAGCCCTGTTGGAATTTGGTCAGTGG


TCTGGCAAACCCAGGAAGGAGTTAGCTTATTCTTCAGGAAGGACTTTCTCTTAATCTCCTGAGTATTTGTCCTTCTGAGCCTGGCTT


TATTTCAAGGCAAAGGCTCTTTTGAAGTGTTAAATGTATTAAGAGCTGTTACCAGTAAATAGAAAGGAGACCTAACCAGGGCTTCAG


CCAAATTACAGACTTTGAGGTGGCAATGAGAGTTTGACAGTAGCGGCTCTTCCAGACAGACCCAGGAAACACACTCGGAGTGAAACC


TCAGAGCATGCGTGTGTTATGCAGTGGAAGAGCATTGTCTGGAGTCAGCCCCCAACACTGCATAAAAGGAGGACATGGGTTCCGTTG


GTAAAATGCTTGCCACATGAACATGTGGACCTCAGTCCATCCCCACACTGATGCAAAAAGCCAAGCGTGGCGGCACATATTTTTAAT


TCTATGCTGGAGAGATGGTGACAGGATCCCGGAGCCTGGCTAGTGAGCTTCAGGTACCCATGAGAGACCCTGTCTGAAAAACATGAA


CTGGATGGCAACTAAGAAATGACACCTGAGTAATCTCTGGGCGCCACATGCATGCACATGCATGTGAATGCAGACTTGCACAGCACA


CTGAATATGTGAATGCAAATGCACACCCCTCCGAACACACACACACTGCATAAATGTAATGATATATTAAAGAATAAGGAGAAAAAG


GCACCACTCCTTATATTTATGGAATGCTTCTATAATATATTGACTAGATTATGGAAAATGTACCATTGCCCAGCAAACAGTAACCTT


TTGAGACAAAGCCTTCCTTATACAAAGCAAGACAGCTTAAGTTCCCTGAACAGATAGGTTCATCCCGCGAAACGTCTCTGTTGAATA


CCAATCTTCTCATGGATTGTGGTTAGCTGCTGCTTCATCCCAGTTAAGCCTTGGGATTTGTCCTGGTGGAATCTCAGAAATTCCCCT


TTTAGAGCTCTCTGTCTGGTTAAATGCCAGATAACACGGCTTCTTGCAACTCCTTTATTAAGAGTCCATTTCTGGCAGCTTTGACAG


AGATACCAGAGGGCATTAAATGAACTAGTTGTCTATTCTTGTAATAAACAGGGAGCTGGTCATTTTGAAGATTTTTTTTCCTCTTTA


TGAAATAGAATTACGTTTCTATTTCGTTGGTCTCCTCACATGTCTTTTCTGATGAAATTTAAAAAAAAAAAATTCCAACATTGGCAG


CAGCTCCCAAATACCCGGGCTGCCACCATGTCAGAAAAGGATGGCATCTCAGTCCTTTATCAGGGCCCCTGCCAGTAAGTGGGACGT


TTTTCTTGAGAACTGAAGTTACATGGCCCAAGTCATTCAGCAGAACTTGATGAGCAAGAGGAGGAGGGGCTAAAAGTATCCAGCCAT


ACAGTAGCCCAGCCCGTGGCCCACAGCTCATGGGTCTGGACCTCTGACACAGGGCTATAGCAAGGAGTGCTGCAGAGTCCCCGCCTC


AGCCGGCTTACATTCTAGGAGAGACACTTGCTGGAAGGAGGTCACTGGCCAGGAACTGCATCCAAACACCAGCAAGAAGCATTGAGT


ACTGGCTATTTAGAGAGTGGCAGGAGACCAGTGTCTAGCATTCTACAGTTTGATTGTTGTAGTGAGGACTGAACCCAGGGCTTTGTG


GCTGCTAGGCAAATGCTCTGTTACTGAGCCCTAACCCTGAGATGTCCATTTTGGAGCTGAGAACCTTCCGGAGGAAGTGTCATTAGA


CTCTATGGAGTAAGAGAGATCTGCACAGGAACAGGCTGAGGACATTCCAGGAGGAGGATGGCGAGGACCTTGCTGACTCCGCCTGCC


TAACCGCAGACGCCCCTTGTCTGAGACCTTGGAGTCTTCAGCAGGCCAGATCTCTGGTTCAGAGTGAACCCTAGTCAGGTGGAGGGT


GGAAAGTGGCTGAATCTGCTGGGTTAACATCAGTGTTAGTCAGTAAACCCAGACAAGGCTGTGGCGTTTAGTTTGAAGGAGGAGGCA


AGGACTTTGAACTGCGTCAAAGCTGGAGTGATGTTAAATCCACGGTGGGGATCAGATTTGCTTAATGTGAAAAACTTGAAGCACACT


TAGGTGGAGCACAGGAGCAGTGGAGGCTAAAGTAACTACCCTTCAAAGTTAGTATCTCTCAGTCCGGGTTAATAGAGCAGGTGAATG


CTAGAAAGAATAATTTTATGTAAATTCCAGTTGCCCTTGAAGATACAAGGAATGGCTGCCTCTCCAGGGGAAGCTGGTCTGCATTTT


GTTTTCTGAGATCACAAGATCTGTTCCTTAGAAGGAAACTTAGCAGTTACATAGCGTGAATCAGGTCTCCAACACCCTTGGTGACCT


GTAGCCGTAGAGAACTCATTACTTCTGATAACATTATTGAGCACATAGCCTGTGACGGAGCCTGATACTGAATCTAGGAAGATGAAG


CAAAGAGTTAGAGTTCTCAGATGCAGGAAGGGTATGTGTATACTCACAAAAGACATGCATATGAGAATAACTGCATTCAATGGTGGT


CGGAGTGGTTGTGCATTGGAGAGATAAACGACATGCATACGATAATGCTGCAGTCAGCGCTGGTTGGGGTAGTTGTGCATTTCAGAG


TTCCCACAGTGCCCTACCCTCCCCGTTTCTGTATTTGGGATACTTTTACTATTCAAATCACTATGGATTTTCACTCTGTGTTGGATC


TCTCCTCTTAGCTCTTGGGGATTTTTAGGATAGAGCTCTGCTTCCTTTGGGGTATGCAGGTAGAGCATCTGTAAGAAACACATAGCC


TCAGAGGACATTTTTCCCAAAGCTGTGGGAATTGCCAGGCCGGGGGCCACCATGGCTGTGTTCCCGCCTTCATTACTATGGAGGACG


CGATGGATAAAGAATACCTCACGCCCAACACCCTAGTCCCCGGTGGGCAACACCGTGGACCTGCCCATGGCCCTAGATAACTATGAC


AACCAGGCCATAGAGAGCACATATGTGTGTGCAGATGATAATGAAGCCCATGGAATAATGTGTGGAACAACCTAGTTGTAATCGGCT


GAATTTAGCTTAAAAACTCCGGTCTGGCATGGCAAAATCACTCACCTCCTGAGTGCCCAGCGGAGAAACTTCCAGCCGAGAAATAAG


TCTGGTAGACCCCACGCAGACACGTTCATCTGCTGCTTAGAGAGCAAAGCCTACAGGACTCAGCTCAGGTCCAGAGGCTCCCAAGTA


AGGAACATGAGTCTCGCCTTACCTGCGCACTGCCACTGGGAGCTAAGGAAACACTTGCCAAACTGGAAAGGTTAGTGAGAGAGTGTT


TATGTTAACGAACGAATGTGGGCCCTTGTTACCATTTATTTGCTTTTTGACATTTACGAGTAAATAAAAGTACTAAAACCTTTTCCA


CCAGGTTTTGAGGAATTTGTCTCTGCCACGCTTTACAGCCCAAATCGCGATAGCATCCTTTCTCTGGGTCGTCCTCCCATGCTATGG


GCTGGAACCCCACCACCATCCTCTTGGACATGCACCTCTGGCCTCCCTATAGCCTACCCTTTCCACCACTGAGGGGACAATTGAGGA


GCCATAGAAAGTATGCCTATGGCCTGGAGAGGTGGCTTAGCAGTTAACAGCACTTGCTATTCTTGCAGAAGGCCTGGGTTCCTTTTT


CCAGCACTTACAAGGAAGTTCACGTCTTTCTGTAACTACAGTTCCAGGAGATCGTATGCAGGCACTTGATATACATGGTGCAATACA


TACATACATGCACAGGCATAAAATATAAATAAATAAACCTTTAACATTTAAAAATATGTATATATTTAATATTAATTTTATATAAGA


ATATATTTAATATAACTATATTATATATATACATACAATATATTAAAAAGGAAATATGTACTATGTTTTGGGTATCCATGGAGTTTG


AGATCCACTGTCCATCCCTGAGTCCACAGCTTCCTGATAGTTCCAGCTTGTTATCAGCCCCAGCTGCCTTACCACGTAACCCACACA


TCTATCTAGGTTTGGGGCTCAGTGGACAATTCTAGGCATGCCTACCATCACATCCACCTTTTCTACTTCTAGAGCCCAAACCGTTCC


TCTAGAAGGACACCCTTCCGCTCAGTGTGGATTCGGCCACACACCTGGTCAGTGTCCTTCACTTCCTCCTCCTCCTCCTCCTCACTC


AAGCCTTCCTCCTTCAGCCTTCCTTCTCCCTCTGTGAATATGAAGCTGTAACTTGAAAAGGGCTGGAGTGGTCCCGTGAACACTGGC


TGCACAGGCCTCAATCGATCGTTCCAGTGGCTGTCACTAATGAAGGCCACTGGAGGAGTGTTGATTGGGTGAAGGACGCAGCTCAAG


TCACACCGTTAGAATTCTCCTTTGAGATCGACAGGCACTCGTTCAGGTGATGTGTACCCTGGGGTCGGGCATCCTCTCCGTCATCGG


CAGCATCCTTTCCTTTGTCATCCCTCCATGTCTTTGCGAGCCCGGGAGCTTAGTTGGACCTTCTGTTTCCTTACTGAGCCCTTGCTA


GGTGTCCCCACATAGTTCAATCTCATGCACAAACCCAGTGTGGTTTCTCATCCATGGGGCTCTCAGAAACCCATCCCAGCTCCGGGT


TGCAGTGCCTCACTCTCTCTTCTGCTCACTTGATCCTAGGAACTCATACTCTGCTGCTTTTCTTCCCTCATAGCCTTGCCAATTCCA


CCTCTGCCCTGAGACCACCACTGCAGGTATCTGCAGAGGCCAGAAGAGGCCCTTGGATGCCCTAGAAATGGAGTATGGATTAGCTGC


TTGATGTGGGTGCCGAGAACTGTACCCAGGTCCTCTGCAGAACAGTCTGTGCTCTTTACTGCCAAGGCCTCTCTCCTGTCCCTGAAT


GGCACCTGTTAGTGTGATGATCGAGAAATGCTCTCCAGGGGCTGGAGATGTAGCTCGGGTGGCATAGTGGTTCCCTGGGGTTCTCAA


GTCCCTGGGGGCCATCTCTGGTACATAATCCTGATATGGTAATCTATACCTTTATTCCTATCACTCTGGAGGTGGATTTGGGAGGGC


CATGAGTTAAAGGCAGTTCTTGGCTTTGTAGTTGAGGCTACATGAAATCCCATCTCAAAGAAAGAAAAAGTGGGAAATGGGGAAACA


AGAAAGAAAACATGTTGTTTACACAGGGCATCCACAGGGTGGTGGATGCCTGTAATTCCAGCACCTGGCAGGGTAGTGTAAGAAAGA


TGGTTATAAATTTGAGGTCATCTGAGGCCACATAACAAGACCCAGTATTAAATGCAGTGATAAGAAATATGATCTCTGAACCATTCA


TCAGTGAGGAGATGAACATTATTTTAAGCCCTGGCTATTCCATGGCCTCTCTCATTGAGCAACAGAAGTCAGTAGTTCCCTAAGATT


TCTCGTGAATGGACTACTTTCACATTTCTTACTACATAAAAGGAGGTAAATTACACCTGGTTTGTTTCTGATATCTGGTATGAGTGA


CACAGCCTTTGAAATAGCAGGCTTGGAAGTTCTGGGAAATGGCCTCTCGTTTCTCTTGTTAAGAAGGGGACTCCGTATGATACCTTG


TTTTGTTAGAGAATTAGGTGTTTTCCCTCGCCTGCTTTTGTCTGCTTTTCTGCTCATTATTACTTAGTTCCCGGCAGGCAGGGCAAG


GGGAGGAGTGGCCTCCCTAACTGTTGAAAGGGAGAGTTTTATGGCTGTTAACAGGGGATGAGAGGACTCCACTTCCCAGAATAGGAA


AGAGCCCTTCCTTGATCCTGCCTGTGCCTTTTGGATTTCCAGTCTCCCCTGCCTTCTCTAACACAGCCTCTGCTACTAGGCAGACAA


CTTCTGGGGCCGTGCTTGTTATTCAGTAGGGAATACCAAGGGGACAGGACTTACAGCTCAGTGGCCATGTGACCTAGATAGACATCC


CTACAGGGGAAGGGAGGTTTCTCCCTTCAGTGATTTGGCAGGTTGACCTCTCTCACTTTCTGTCTGTTTCCCCACCTGGAGTACCCA


GGTTATAGGTTTGTCATGAGAGTAAAGTAATGCAGGTCTCAGCAGGGTGGCTCTCAGGACTGGGCCTTCTCCACAACTGCCCCACCA


GCTGCGTCCGTGGTGCCTAGCCACTGCCTACATGGAGCTTCCTGGTACAGAAGTGCCTGGGCTCTCCTCTCCTGAGCATCCGCAGGG


CAGGTCCAGTCCCATCCAGACACCCTATTCTGTCTTCGTCATTTGTCACATCCAGAGACCCTGTTGACCAAGTTGTTTCTGCGTCTC


AAGTCTGCTGACATGGCCTTCCATCTCCGAGCACATGGCAGCACTCTTGGATAGCTGCCCATAGCCTCTCCCTGTGGACAGGCTGTA


GGCTGTCACTGGATCTTACTCTAAATGGCCAAGACTGATGGAGTCCTTGGCATCTCAACTTCAGACTGCAGACTAAGACAAGATACT


ACACTGTGGACTAAATGACGAATGATAGCCCTTGGTCCCTCACAGCCCTGAGAAGGATGGCCGTCTACATCAAGGCGCTGGCTGGTT


CCAFTCCAAGAGAAGACTGTCTGTCGTCCTAGTCTGCAGATGGGTGAATCCGCACTGCATCTGCACAGGGCAGGATGAGAGAGGCCA


GGCTCTGCTCTCTTCCTCTTCTTACAAGGACCCCTGTCAGGGCATTGGGGTTCTAGTCTCATGGCCTTCTCCTAGCCTAATATCCTT


CAAGATATCATCTTCAACAATTGGTGGTGATTATGTTTCAACATACTAATGGGCTGGAGAGGCGTTCAGTCCTAAACAGAGCTTCTA


TTGCTTTTTCTGTTTAAATATTCTGTTTAAGACTAGAATGTTCCTAAGTATATTTTCTGCCTTCTAAATAGATACATGAAAGAATCC


AGCAAGCGGCAAGGAACACAGGGACCTTAGCATGTGGGGACACTTCTGTGTGGAGCTGTGTCTGCGGGACAGTCACTCACTCGTGGG


GGCGGGGACTGTGTCTTCCCTACCTGTGAGCAATGCCAGCCTGTGGAACTTGGCCCAGCTGTCCTCCCAACAGCTGCTTGACTGCTA


GATTCTGTATAGGCTTAAAAGATGATCGTAACCCTCTTCATCTCTTCAAAGATACCTCATGACGATTTTTTTTTTTTAATTTTGCAA


GAAAGGATTACTTGAGTCACTCTGATGAACTTGCTTGACAAGGTAAAATGGAAGGGATCTTGTGCCTTTGAAGCAGTTGGCTTTCCT


GCTTGTGAGCTTTTCTACTAGGTGTGAGCTAGGCTGCTCTCGCCCCATCACATCTCCTGACACGCTCTCCTGGCACTCTTCATCCCC


TACCCCCTCTGGCCTCTGCGCAGTTCATCCATCCCGTAGATGGAGACTTGGGTTTTTACAAAATGACTGCCATGGCACATTCTTGGA


GGGCCTTTGATGTGTTTCCATAGTCCCCTGCCTGGTCCTTCTGCGGACATCCTTCAGAAACACATTTCCAATTCTCCAGGACAACCC


CCTCTATGGGGAGCTGCATGTTCTTTGAAATGTCGCACCCGCCATTGTCAGCAATGGAAATGGCTCCTTCCCTCGTATCCTGGGGAG


GTTTTCAGGCCCACCATTACGGTAAGGCCTGGTGTGTGGGGCATAGGTGAATCAGGACCCAGTGTCAGAAATATCTCAGCGGAATTC


AACTGGTCTGGGTTTGTACACATTTCATATGCCTGCCTCTCTGTTTCTCGTCCAGCCGTTGGAAGGAATCTGCTTGTTTATGAAAAG


ACAGGAGAGCCCCAGACCCCGGGGTGCGTTCCTGCTATTTTTTTGCAGTTCTTCTCTGTGTGGGTTGACAGAAGAAACTGCAGCCTG


CCAGGTGGCACACAGAGGCTGCTCTGTGCTGGCGCTGAGGAAAACCACAGACACTCCTGAAGTGTATTGGCTTGGAACACACCGCAG


CTTTGTTTGCCTTTTTTTGTTTCTGGCGCTTGCAAAAAGCAACTTCTTTGAAGAAGAAATTGTTACCCAGAACAGACTCCTCTCTTG


CGGGAACCGTGAAGAAGATGCTGCTTCAGCAGCAGAGATGGCTGGGCGGATGAGGTGCTGGTGACGCGGTGGGGACGAAGGTTGGCG


GATGTTTCCACCCTCTTACCGGAGCTTATGCGGACAGACTGGAGTTGAGCAACCATAAGAAGGTCACTGCAGAGTTCTGAGTCCAAC


CGCCACCATGTGCTGTCAGCTCCCTGGCTGCAGAAGGATCCAGCTGCTGCTTGGGCAGGGTCCCCTTGAGGCTGTGACTTCTCCGTC


TTCTTCCTCCCGCTGTGCCGCTTCTGGGTACCCATAGAAGCTTTTACCTAGTCCTGCTTTTGCTCCCTCCTGGTTCTCCCCTCTGCC


CTCCTCTGTACAAGCTTCTATTATTTTTACCCCCTACCCTGTCCCGCAAAGATCCAATTAGCGAGCTCCAGATACTTTTGCCTCACT


TTGTGAAATCAACAGAGTGGCCTCAGATTTCCTTAGGCACCAGGCAGGGGAAGTACTTGGAGCAAGAGATTCCTCTCTGGTAGCGCG


TGCGTGCGTGCGTATGTGTATACGTGCGAGTGAGAGCGAGTGTCTTAGGGTTTCTTTTGCTGAGACAAAATAGCATGACCAAAAAGC


AAGTTGGGCAGGAAAGGGTTTATTCAGCTTCCACTTCCACATTGCTACTTATCACCAGAGGAAGTCAGGGCAGGAACTGAAGCAGGA


TCTTGGAAACAGGAGCTGATACAGAGGCCATGGAGGTGCACCGCTTACTGGCTTCCTGCTTCCTTGCTTCCTTGCTGTGGCTTGATC


ACCCTGCTTTCTTACAGAACCCAGGACCGCTAGCCCAGGGGATGCCAACTCCCACGTTGATCACTAAAGGAGGAAATGCCTTACAGC


TGGATCTCCTGGAGTCATTTCCTCAGCTGGCTAACTGGGCTCCTTCCTCTCTGCTCACTCCAGCTTGTGTCGAGTTGACACACAAAC


CCAGCCAGAGCATCCTTCCTCTCAGATGTACCCGTGGATGTGGTGGCATCCCCTTGTCCTAACGTAATAGAGATGTGGATGATAGAG


CTAAGCTGTCACTGGATTCTTTTCTGTGCCAGGTATTTCGCGCAGAGTGTTTGCATTTACTTGATCTATCTCGTTCTCATAATCACC


TTATGGCATATGCTATAATTTCACGGATGTGTAATTGAGGCTTAGGCAGGTGAGGCGGCTTGCCTACAATCACATAGGCAGTAAAGC


AGAGAAACTGAGATGCAAAACAATTTTGCCAGATGAAAGATAATAACAAGTGCTAATGAAGGTGTGGAAAGTGAACCCTTGCACAGT


GTTGGTAAAAATATAAATTAGAAGAGCCGTTATGAAGAAAGGAATAGAGGTCCCTCAAAAAATGAATTAATCTATAAAGCTAGGAGC


CATGTGAAATAGTATATAGAGATAATCCAAACATCTAAGAGGCTACAACAGGAGGATCACACTGAGTTCAAGCCCTGCCTGGATTGC


ACGTTGACTTTGAGGCCAACCTGAACTACATACTGACATTGCTTCAAATGAAGAATTAAAAACAGAATTGCCGTGTCTGGGGAGGGA


GGTGGGTCAGAGGGCAAAGTGGTTACTGTGCACCGGCAAGGACCTAAATCCAGATCCCCAGCGTCCGTTAAGATCAGGACAAGATGG


CACACACTTTTAAGTCTGGCACTGGGAGGTCACAAGATGCCAGGATCTCACTAGACAGTATAGCCAAAATGGTAAACTCCAGGTTCA


GGAAAGGACTCTGTCTCTAAAAACAAACAAACAAAAATGATGGAGAAGCAGTTGAAAAAAAAAAAAAAAAAAGTCTAGTGTCAACGC


CTGTCTTCTACATACTTCCCACACATCAGGTTGGCACACATACATGCATACGTATACATAGCTCTGAAGAAAAAAAAAAAGACAAAA


TAACAAAAGCTGGTTGTCCAGTTTCTGGAGTGGCGATTTGTTGAAAACACTTGTTGCTTTCACGTTTGTAATGGACTGAGCTGTATC


TCGTGTTTAGAGCAGCGCTTTATGTTATGAGTGATTCGGCTTTCCTCTCTTGCTTGCTGGGACAGCCGTAATCTGAGCTGGATTGCA


GCATGAATATGAGGCAAGTTTAGGAATGTGTGCTAATTTACATCAGCTCCTATTATTATAATCTTAATATTCTTAATCGCACACACA


CACACACACACACACACACACACACCACCATTATTTTCCCTTATTCTCATCCCTTCTCTTTCTGCATCTGCTTCCCCCCGACCCCCC


AAGGGGGTCAGAATCTCCCTTCCTTGTCACCCTAAGCACAGGTGACCAGTCACTCCACTCTCCCTCCACCTAGACTCAGCATCTCAG


AGTGGCATTTTCTGACTTCTGCCAAGGTCAACATCATTGGCCTCACTACCCCCTCCATGCCTGGAGCATACAGGTAGGAGAAGGATA


AAAACTTGTCACATTCCAGTGCTAGGCCATGTGTGTGTGCTTGTCATGTCAGCTCTGGCTATTGGAGGGACAGTCGCCAGAGGACGG


TTTGTGCTCGTTTTTAAAAAATAAGTTTCAAGATTTAAAAGTTAGTGTTTAAACTCCAAAGCTAAGATAGTCAACTTTACGTGCAGA


ATTAGGACGTAAGCCGTGGTAGTATTGCTGGCCAGTGATGTCGCTACCAGAGTCCCCAGGTTCCATCCAGACTGCTCATCTCTTTGC


TAATGCTGAGTTGAAAGCCAGTTCTCATGAATGAGCCAGGACCAGCCTTAATTGCTGCTGACATGGGTCACCAGCTAGCCTGGAGAA


GGCATCAGTTGAGACGTAGTACTTCTTTCACTCTTCTTCTCTGATGTCCCTAAACAGCCCTTCCCTCTTTCCAGCATGAAGTGTGAG


CTTTAGTTTTAGACAGGCTCTGTTAAAATCTTCAGGAGCATCAAAGCAAGACTCTCTGGGTCCAGATTAAAAACTCAAGTAGAACTT


TCTCTTTTAGTCCTTGTTAGTTTTCTTTCCACCTTGATATTTTGTTTCGAGTTTCCTGTATGGCCTGGCTTTGAATTCACTGTGTAG


CTAAGGATGGCCGTGAACTTCCACTCCTTGCACCTCCATCCCAAAGGGCGGGGGCCACCAGCTTGTATGCCCAGGAAATAGCTGGAA


TCCCCCCTGCTCTTGTGCTGCTTTTCTTTGTCTTTTTTAAGATTTATTTATTTTATGTACATGAGTACACTGTAACTGTCTACAGAC


ACACCAGAAGAGAACATCGGATCCCATTACAGACGTTTGTGAGCCACCATGTGGTTGCTGGGATTTGAACTCAGGACCTCTGGAAGA


GCAGTCAGTGCTCTTGACCTCTGAGCCATCTCTCTAGCCCCCATGTGGTGTTTTTCTTAAGCACCACCTTTGTATTTCTCCATGTGG


TAAAAATTAGCCCGACACATGGTTGTACGTCGCTCCGTGGCTCTCGGTGTGCACTTTCCTAGCTCTGGTCCCCAGAGAGAAGAGCCG


GTCATAAATGTCTGCATCCCAGCGGGAGGACTTGAGACTTCCCTGCTCTCTGGGGTGGGGAGGGGCTCTGGAGAAGCTGGGGAGCAC


TGACAGGGATGAAGAGGATGAAGAGGAGGAGTCCCCACAGAAGAGGGTGGGCGCCACAGGTTTCTGGTAACCAGGTAACTGCTGTTT


TCTCATCACAGGCTCCTCAGGATTCACTGCAGATCTAAGCACCTACTCTACACTTGGCTGACTTACCTGTGACCTTAGAGTTGTAGG


TTTTTTTTTTTTTAAGCTTGCATTATCATTATTATTCAGCAGGCATGGACTAGCACTTCTTCCTAATTTGTCATATTCGGCTCCCCA


GAATTAAAAGTCCAGGGAGAGCGCCTCACGCTTCTGACACCAGAAAAATGACGCCTTGGCTCCCATCACTTTTGTAATCTAAAAAAT


GAGGAATGTATGCGGTTTGTTTTGAAGTCCTGTGTAATCAGAAATAGACCAGCTCTCTGAAGCAGTACTGACAGATGGGAGCATCAG


CCTGCTTTCCCTCCGCATCGAGATTCTAACCTCATTCCAGGTGACAGAGAGCATACTGAATATACTGTATGCTTGAAGAGTACCGAG


CGTGGGTGTGCTATATTCTCCCCAGCAGAAAGTATAACTGTGGGGTAACGAGTGTTATATGGATTTATTCATTCCAACACACACACA


TATACACACACACACACTAAGAACATCCAACTTATTAGGTAATGTAATATTTATTTGCTGTTTATATTTTGGGAACGCTCCTCATTG


TCTCTCTCTCTGTCTCTGTCTCTGTCTGTCTGTCTCTTGCTCACTCGCTCTCTCTTGCTCTGTGTGTGTGTGTGTGTGTGTGTGTGT


GTGTGTGTGTGTGTAGCCCCAGGCTAGTTTCAATGTCTCTAGCCTAGGCTGGTCTCCAACTTGAGATGTCTTGCTTTCACCCTGAAT


GCTGGGACTGTAGACATGTACCACCACAATGGAAGTGTATGTAAGCTCATCTGTTCCTATGGTATAAGGTTTTCTTTTACCCCACTC


TGGGGAAAAAAGAAGTCTGAATTAATTTACAACTGATAACAACTTGGGTGTGCTCTGAACCCATCAAAAGTAAAGTCCTCAGGGGTC


CTCCCTGTGTTGCATGCACAGAGCCCCTGGCACTTGGTGGTACCTGTCTCCAGCACTGTCTTTTCCTGGAATTTAGAATTAGATAAG


GAAACTAGGCTCTCAAATTATCATCGGTTTCCATGGAAACAGTTGAAAGCCCCTCAATTAAAAGTGTCCCTGCAGGCTAGGGAGAGT


ATTCAAATGAGCTGCTCTGAGAAGCCAAGTTATCCTCAAAGTGAAGCCAGAGAGGACGGAGGAGCAAGGAGTCTGCTAGAGCACCAG


TTGCGATCTCTATTATTTTTTTTCCATTCAGGGAAGAATTTTATCTTGGTATTTCATTTGTAGCATGTTTGTTGGCTTTGGCAGAGC


CACCTAGATAATTGTCCTGTTATCTACTAAGTTTTTTATGCTCGCCCATGGATCACGGAAGTGTTTGAGAACGCTCTGAGCTTTGCT


CACACATGAATATGAGTCACAGATAAAAAGCCCATTTAAAAAAATTGATGATATCCTAGAAGAATACTAAGTTGGAAAGAGTCTGTG


GGTCATTAAGAACTAACTTCCCACCCATTTGGGATTCCTTGCTAGAGTGCAGTAACAGAGGTTGTTCAAGGTATACTTCAAACAAAA


AAAAAAGAATTTATTTATTTCAAACGTATGAGCGAGTTACATGCATGTATGTCTGTTTGCCGCATGCATGATGCATGGTGTCCTCAG


AAGTCAAAAGTGGACATTGGATTCCCTGGAAGTAGAATTATGGGTGACTGCACTATGTAGGTGCTGGGTTCTCTACAAGAACAGCAA


GTGCTAACCACGGAGCCATCTCTTCAGTCCCCTCACATTATACTACTAAGGAAAGCAGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT


GTGTGTGTGTTTCATGGTAAGTGCTGGAGAGATGGCCCAGTGGTTGACAGCACTTGTTGCTCTTCCAGAGGTCCTGTGTTTAGTTCC


TAGCACCAACACGGCAGTTCACTACCACTTGTGACTCCAGTTCCAGGGCTCTGACATTGTCTTCTGACCTCCATGGGCACTAGGCAT


GCATGTGCTACCCATAAATGCAGCCCAAACACTCGTGTACATTATAAAAGAAGATTTAAAAAGACAGTAATTGTATACCTGTCAAGC


CAGGTGTGAGATCTCTGCTTGGAAGTTGGCAGTAGAGACTGCAAACTCAGGGCCTTGCTAAACCAGCACCTCATGCTTCCAGAAGTC


ACATAGAAAAACTGGATGTAGCAGCACACGCCTGTACTTAATACTAGGGAGGCAGAGATGACATAACCTTAGGGCTTGTTGGCCAGC


CAGCCTAGCGGAATGTATGAGCCAGTTCACTGAGAGGCAGTTCGCAAAAGCTAAGATGGATCATGATTGAAGTTCAACACTCTAGTC


CACAAACACAGTTGCAGACTCATACACACGTTTGACACACACACACAAACACATAAACTCACATGCGCACGCATCTGTTTGTTGTCC


CAAGAAACACACTTTATCATCAGAGACAAAAACCTGAAGATGAAAGGTTTTTCAGCCCTGTGGAACTGGAAAGAAATCAGGGTATAT


CAGAAATATCTGACAAGATAGACTTTAAACCACTTAGATGGAAGACATAAAAAAGTTACTTAGTACTAATTAAAAGAAAAAAATCAC


AATTTGAAACATGTGTATACCAGACATGTGTGTATCTAATTTTATAAAACAAACACTGTTGGATTCAAAGAGGCAGATTAACCCCCA


ACCCAGTAATAGTTAGTAATGCCAGCACTCTACTCTTACCAATAGGCAGTCCAACAAAACCTAGAAACATCTAAGTTAAATGACACA


GGTCAGATGGACCTAAGAGACATCTGTGGAATGGTTCACTTAAACCCTGTAGAGTCCACATTCTTTTCGAAGCTCAAGGAACCATTG


TATACTGTCTGATGACAGTGGAGTGAACCTTGAGATGAACAGCAAGAGGAACTGCAGAGTGTAGAGCTGAGGACCCAGGACACATTC


CTGGATGAAAGCAGTCCTAAGCAGTTAATTCATAGCTACAAGTATGTACACTTAGAAATTAGAGCTCAGGGTTGAAGAGATCGCTCA


GCAGCTAAGAGAAGAGCCCTGGCTGCTCTTCCAGGGACCTGGGTTTTAATTTCCAGCACGCTCATGGCGGACTGCAACTGTAACTCC


ATGTCTGGAGAGATCTGTCTGACACGTCTTCTGGCCTCTGTGGCACAAATGTAGGGCACAGACAAGCATTCAAACTGAACACTTGTA


CACATCAGAAACATTTAAAAGTTATTTTTAAAGAAGAAACCAGCTAGTGATACATGTCAGGGCCTTGGTAAACAAGAACAAGCCAAA


CATAAAACCAACAGATGGGAACAAAGACTCAGGATCAGGGCAGATGAGCGTCATGAAACACTCAAATGACAAAGAATCAGTGAAAAA


CAGGGCTTTGGAAAAATAAACAAGATTCACATGCTCTTAGCCAAACCAAAAGGAAATCCATGCAAATTAATAAAATTAGAGATAAAA


AGGGAGGCATTGTAAAAGACACCAAATGAAAGTCGGAAAATCAATAGGACCCAGCCCTAAAACTTTTGGAAATGAATTTCTAGACTC


ATATGGCCTTCCAAAACTAAACTAAGTTTAGATAAATAACTTAGATCTATTTTTAAATATTTAAACAACAACAATGACAATAATAAT


AATAAACAACTGAATTATAATTAATAATAATAATAATAATAATAATAATAGAAAACAACTCTGAATAAAGTAAAATAAAATAAAGGC


CAGGCCCAGATGAGTTCGTTCCGTTCTACCAAGCCTTTAAATAAGCATACTATTCCAAATTATTCCATAACATAGAAGAGGAGGGAA


TACTGTCATTTCACGAAGTCCCATTACTCAGGTACCAAATCCTCATAAAGGTACAGAAACAAGAAGACAAGAGAGAAAGAAAGGGAG


AGAGAAGGAAAGGAAGAAAGACCGTAGACTAATCTCCCTAACGAACGCATTCTCAGTGAAGTCCGTGCAAAGCAAGCGCAAGAACAC


GTCCAAAAGGCCGTCGTCCACATAATCAAGTTGGCTCCGTTTGAGAGATGCAACGGTGGTTAACCATACATACGTCAGTAAATGTAG


TCATCACAGGCATGGCCTCGAGGGTGGAAATCACGTGATCATCACAGTACATACGGATTGGCAAAGCCCCCATCCCTTCATGATAAA


AGCTCTCGAGGAGTCCAGAAAGATGGCTCAACCATTTAGAGCATGTACAGCCTTGCAGAAGACAGGTCAGTTCCTAATACCCATATC


AGGCTTGCTGCCTCTAACTCCAGTTCTGGAGCAGTCTGACATGAGTGGCCTCTGTGGGCACCTGCAAGCACTTGTGTACACACACAC


ACACACACACACACACACACACACACAAACGATTTAAGGAACTCAGTAGAAGGACCATAGCTCAACAATGAAGGCTGTATGTGAGAA


ACCTATAGCTAGCATTATCCTAAATGGACAAAAGCTGAATCGTTTCCACTGAAATCAGGAACAAACCAGGAGCGCCTGCCTTCTCCA


CCCTGCGGTTTGGGAGTGCGCACACACGTGTGCGGTATACATATGCAGAGAACAGAGTTGTACACACGTGTGCAGTATGTGTATGCA


GAGAAGAGAGCTTCATTTTCCCTTAGATTTCGAGAGAGGGTACCCAATGAAATGGGCAGCTTATCTTTGTAGTCAATCTGGCCACCA


AGCCAAATCTACTTGTTCCCACCACCCCACTCCCATTTTAGAGTTAGAGTCACACAACTCGCTTTTATGTGCATGCCAGAGAGCTCC


AGACCCTTCCACTTGCAGAGTGAGCACTTGTTCACTCAGCTATCTCCTCAGACTCCATCCCCGCCCCGACCCCCAACACACACATTT


CTCACTCAGTTAAATATAGTACTTAAAAGTCTTAGCTAGAGCAATAAGTTAAGATAAGGAAATACAAACAAGAAATCAGTTTCCTTA


TTTACAGCTGATCCGATCTATACACGAGAGGCTCTGAAAACTCCAACAGGAAACTCAGAGCCGATGAACACTTCCATCAAAGTAAAA


GGATACAAAAAATTCACATACAACATCAACTGCCTTCCTCTATACCATGGCAAACGTACTGAGAGGGTAGACAGAGAAACAGCCTCA


TTCCCAGCCATCCAAACAAGTACCAAGAATAAATGTAACCACAGCGGTGAAAGACCTCTACCATGAGAACTTTAACACACAAAGAAA


GATGGAGAGACCTCCCATGCTCATGGATTGGAAACGTTAATATTGCGAATACGCTACCAGAGGCAATCACCAGAATTCAGTACCTGT


CAAAATTCCAACACTATTTTTTTCTCACAGAAATAGAAGAAAAAAAATTAAAGTCATCTGGAAGCACAAAAGATCTCAGATAGACAA


TAGAATTTTCAGGAAAAAAGAATTTCAGGTTGATTCATAGCCTATTTTAGGGACGACAGGGCGGTAGTAACAAAACAGCATGGTACT


GCACAGAAACAGACGTCTATATCAGTCGAACAGAATAGAGGAGCTGGGAGCAGAGTCAAGCAGTTACAGCTGCCAACATTTTTGACA


AGATTTTAGTACAATATAGTGGAGAAAAGTCTCTTTTCAACAAATGGTGGAAGATCGAAGCTAGATCCTTATCTTTTGCTGTGCACA


AAAAAATCCATTCCAAATGGATCCAAGACCTTAGCATAAGCCCTGAAAACTCGGAAACCATTGGGGAAGAAAACATTTCCAGACATT


GGCATGGGGTGGGAGAGGCGGCTTAGTGGGTGAGAGTGCTTGCTGTTCTTCCAAAGGACTGGAGTTTGGTTCCCAGCACACACGTCT


GGCAGCTCACATGGAACTCCAGCTCCAAGGGCTTTGAATCCTCTTCTGGCCTCGTCAGGTGCCTGCGTATGTGCATATACACACATG


TAAAGTTAAAAAAAAATCTTAAAAAAAAGATATTGACATCCGCCAACACTCAGTAAGGACTCAGAAAGCAATTGACAGATGGGATTT


CATGAAATGACCAAACTTCTGCACAGCCAAGGAAACAGCAGAGTGAAGACACGGCAACATGGGAGAGAATCTTTGCCGTCCCATGGA


AGACTAACCTCTAGAATATACAAAGAAATAGAAAATGCTACATGGGGCTGGCACGATGGCTCAGCGGGTAAGAGCATTGACTGCTCT


TCCAAAGGCCCTGAGTTCAAATCCCAGCAACCACATGATGGCTCACAACCATTTGTAATGGGATCTGACACCCTCTTCTGGTGTGTC


TGAAGACAGCAACAGTGTACTTATCTATAATAATAAATAAATCTTTAATGCCAAATGAACCAAACAATAAATGGGCTGGTGGACAGA


CAGTTACCAAAAGAGGAAATACAAATGGCCAATAAACATGAAAAATTGTTCAACTGGCCATCAGAGAACTGTAAATAAAAGCTAAAT


TGAGATCCTATGAGAGACAGAGTAGCAGTCATTGAGACAACAATACCAGACAGTGGTTTGTATGGGAACAAAGGAGAGCTCATATGC


CATGCTAGTGGGATATGAACTAATCAGGCCACTGAGACTCAGTGTGGAGTGTCCTCAAAAGACAGAAAAATGAGACTGCCATATGCC


TTAGCTGGCTACCTGTCCAATCCACACAGGACAAGGACACTTGCATGGCAGTGTTCACTACGGCACTGTTCTCCATAACCAAGGCAT


GGAGCCAAGTTCACCAGTATAGAAATGCATAAAGAGAATGCAGTGCGTACACACAATGGATTGCTTTCGTCCATGAAGAATGATGAA


ATTGTCATTTGCAGGAAATGAGTGATGGCGATCATCCAGTTAGGCAGATGAGTTCAGCCTCAGAATGACGAATTCCAATGTTCTCTC


TCTCTTATGGGTATTAGACATTGCATATACATAAAATCATGTGTGTACAGACGATGTGAAAGTGAAGGTCAAACTGTCTAGGGAAAC


TGAGCGGACTAGAGGGATGGGGAGAGCCAGGAAGAGGACGTTAGCAGGATTGGGAGTCAGAGGTGGAATTCTAGCTCAATGTACATT


ATGTAGTTATACTTGCCTGATGTAACCAAATACAATTTAAGAATCTAATAGGGCTGGAGATAGCTCAGTGAGTAAGATGCTTGGTGG


ACAAGCATGCGCGCCTCAGCATTCCACCCTTGTCATTCATGTAAGAAGACAAACATGTGCCTTCTGTTTGTAATCCAGAGCTGGGGA


GTTGGAGACAAACAGAACCCTGGGGCCTTTGGCCCAGACATGCCAGGCAAATCATCCAGCCCCAAGCTCCAGGGAGGTAACCTTGTC


TCAAAAGATAAATAAAATTAAAAACTAAATGAAGAGGATCGTGCCTGAAGAATAACAAACACCCTCTGGTTTACCTCTGGTGTACAC


ACACACACACACACACACACAGGCACACACACACACACCACTGCTCATATACACATACATAATGCACATATGTACACACAGAGACAC


TGTAAACACTTAATACATTTAAGACAGCTGAAAAGGAATGACAAATTGCCAATGTTGATGTTATGCTAATTACTTCAATCTGAACAC


CACACACTGCATGTAGCCACCGACTGAAATTTGACGTTGTACCTCCACAGTACCATGTGCAATTCCAATACATCAATTTAAAATATT


TAATTAAAAATTGTGAGGAAAGAGCCGGGCGTGGTGGCGTACGCCTTTAATCCCAGCACTCAGAGGCAGGCGCAGGCGGATTTCTGA


GTTCGAGGCCAGCCTGGTCTACAAAGTGAGTTCCAGGACAGCCAGAGCTATACAGAGAAACCCTGTCTCGAAAAACAAAACAAAACA


AACAAACAAACAAAAAAATTGTGAGGAAAAATAAACATGTTTTCCTCTCCCCTCCACCTCTTTGTCTTTCATACCAAGCAAATCAAT


ACTTCTCCAATAATGAACTTTTCAGATTGCATCATGTGCACTCAAAGTTTGCTTGGCCACTGACAGAACAAGGTGTGAAGAATTCAC


ACCTGTGGCAAGCCGAGGGGCTGCCATCCTTCCAGCTGAGCCTTGATAACCACTGGCTACATTCTATCTGATTTCTCTGCCAACATT


TTTTCTCTGCAGCGTTTATGTAAGTGTAGACTTGTTTGGTGGTTTCTGTGTTTTCTGTTCAGTTTCTCCAACCAGGGTAAATAAATG


TCCAAGTTCTAAGCTTAAACACAAAACTGGGCTTAGCCCTGGGTCTGTGCCTGCAGTGCCCTGCAGGGTGCAGCACATCTTGGGGCC


CACTCCCCTCCTCCCTGCTTTGAAACTGCCCAGCCTTCCTCTCTGACTTTATTTAAGGCCGCCATCATTTCTACTAAATTAAAATGT


TATACTTTAGTCTTGTAGCTTTTTTTTTTTTTTTTGTCAAACACATTTTGTTGTTTTTTAAGTTGACACTCCTAAAAAGAAACAACT


CAAAAGCTCTAAAATGCTGTTCCCCAAATGTTTCAACAACTTTCCAATGGATTGAAAGTTAAACCTCCTACACTCTGGTTTGATTGG


CACTGCCTGGGAAGCACACTGCGGCAACTGCCTGGCCTGCTTGATCAGGAAGTGCTGAGATAGACATCTGCTCCAGTTCTAAAATAA


CCCATGACCTTCAGCCCGTCACCAAACTGCTCCAAATTCGATTTTCCTCATCCAAAATCAGATGTGTCAGCCCTGTTCCAGGTCGGT


GGCAGTGCTGTGTAAAAAGACATTCACTATCTTTTTTAGATTGGATGGTAAACCATACTTCAATTAAGTGATTTGATTTGAGGTTTC


AAATGTAATAAGAAAATCAAATAGTGATGATTCTGCGTGTTTCAGGTTCTCAGTTCCCAGAACACTGTCGCTGGTCTCCAGAGACCA


AATCCAAGGGTGTCCTCTGCATTTTAGAGAATCAGTATCATAATTCCTGGCAGGCTTTGACATGTTCTCACACTCCAGAAAGGAGTT


CTCTTAAATGGGTATTGCATGTGGAGAAATAAAATCACGTTGGATTCCTTATGTAGTAGAAGAATAAAGGAATTGAAAGTAAGGGAG


CGACTTGCTTGTTTTTAATCTCAGCCCCTGAAGTGTGGCGAATGTCTCCACCACTGAGCACGTGAGCAGACCTGTGGGATCCTTGGG


ACCTGAACCTGACGGGGTTGTCCGGGAGGCTCAAGTGTGGAGTCTGGCAGAGCGCTTTACCTTGGGAGGCCTGTGAGCGCTTGCAGA


CAAGCCTGCAAAGTTCACTCACAAGCTCCTCGCTCCCCCACCCCACCATATTTCTGGAAACATGCCAACGGCTTCCTTGCCAGTGGT


CCCGGGGGACTTAAAATGACTTCTTTCTGTCCAAGGTAGTGTATTTGTTGTGACATCTACTTTTTACTCAAAACAGTATGTATTTGA


GGGCACTGAAACAAAGATACCATCTATAGTTGCTCCACCCAGAGCCTGATAATGGTGTTTTTATTAGTGTTGGTTGGCTATTTTATC


ATTTTACCAAAAATACAAGCACGGTTGATCCTGCAAAGAAATCTATTTCCCTCCCTCCCTTCCTTCCTCCTTTTCTCCCTCCTTCCT


GCTTTCTCCCTCCTCTCCCTCCTTCTCTCTCTCTCTCTCCCCCTTCCTTTCTTTCTCTCTCCCTCCCTTTCTTTCTTCCCCCTCCCT


CCCNNNNNNNNNNNNNNNNNNNNNCCCTCCCTCCCTGCCTCCCTCCCTCCCTCCCTCCCTCCCTGACTCCATCCTGGTCCTCCAGCC


TTTCTCTTCCTACTTCCCCTTTTCCTATTCCTTTTCCCCCCTTTCCCTTCACTTACCTGGTCTCTTGACTACAGTCATCCCAGATTG


CCAGCAGATGACTGCTGAATATGGCCAGATAACTCCTGTGGGAGAGAATGGCACTTGCTGGCAGCTTGGCCTGGTGTCCTGAGTTTT


GTTTTTTTGTTTTTTCCATCTCCAGGGTGTCCTCTCCAACATCTCGTCCATCACCGACCTCGGTGGCTTTGACCCAGTGTGGCTTTT


CCTTGTGGTGGGAGGAGTGATGTTCATTCTGGGGTTTGCAGGGTGCATCGGAGCACTTCGGGAAAACACCTTTCTTCTCAAGTTTGT


AAGTATTGCAGACTCTGCTCTCAGCCTGAGATCTAGGCTCTTGTTTTACACCAAGACGACAGTCTTAGCTGCAGCCAGGATAGTAAG


CGTGCCAAAGACCTGGGCAAAACATGCAGCCTAGTCCACTTTCATTTCAAGAGCGCTCCTCAGTCCTGCCCGCTCTTCCCTTGCTCT


AGACATGCCTCCTAGGCAGTATACATACCACCTAGTCTTGCCATGCATGGAGACTTTGTACATATATGCAACGCATTTGACTTCAAT


CCCTAAAGTAGTTTTAGGAAGGAATGAGATGTTGGGGGCGGGGCGAGTAGTTTGTTGGATGTTGAATGTGCATGTGTTGGTGTGTTG


GTGGTGAATATTGTAAATAGAAAACCTAGGGTAACAAGGCACTAGCCCAGCTTCTATAGCCTGTGCAGCCTGCACAGTTTGAATAAA


CATGGCGATACAGTAAAGGTGAAAGACCTTCTTAGTTTCACCACCTGTATTTGTAAGGGGGGGGGGGACTTTAGCAGGAGGTATGAA


ATATTCAGAGCTCGTCCTAGAGAATGGGCAATGAAAGCCTTCCCTTAGGGCTCCTTTCCAACAGGACAGCGGCATGGGCCACATATC


AGTATCTGAAGTCAGAAGAATGGTCAATGTGAAATGCAAATACAGCTTCCGTGATGGCTGATGTCATCAAATGTAACTTCAGGTTGC


TTTCTGTATCTTTGGAAAGAGAGGACTTAGCTCACAGGGGCCCCGAACCTGTCAGTTTCTGCCAGATACTTGGTATGAACTGAGTTT


GGCCTCTTTGTGTGTGGAGGCTGGCATTTTAATGATTGCTGTAGGAAAAGTATTCACTCTCCTCTCCAAGAACAGGGAAAGGATCAG


AAGGACCCACTGTCCCATGATGGGGGAGGACAGGGGAATTTCTAGAGAACAACTTTGTTGGCTATGCCTCTTATTAGAGCCATTCGC


ACCAGAGCCCATCCTAGAACAAGTCTGAGCAGCCACACGGTGTGTGATTCTCCGACCCCACCATGTCTTCTAGAATGTTCTCTGGCG


TTTTTTATGAGCATCTCTAAGAAGATACTCCCATGCCCATTCTAGGGTAACCCATTTCCAATTGGCCCAGCTCTGGCTCCCTGAGAA


GCCTTGGAGGCTGTAATCCTAAATCTTTTCATGTGGCTCACACCTATATGGAAGACTGGGGTGGGGTCATTGCTCTCAGATAGCACC


CTTTTCCTGTGCATGGGAGTAGCTAGTTTCCCATGTGTAGAGCTGCCTTGATCTTCCAGATTTGCCCCTTTCTACACAAGCTTGTGT


GATCTGTCCCTTCTTCCCTTCTCCCTCTTCGCTGAGTCAAAGACAGATGGAATCCCTCAGAAGGATATTTGTCCTTGATCATGACCT


GCCAGTCTTATGAGGCATCTCGAAGTGGGGACTTGGTTCCACTCAGCTTTGCTGTGACCCATTATCTGCCGTGTGACCTAACACTTT


GAAACCTCCATGCTTCCAAATACGAGGTCCCTTTAATATAGCTTTCTTGAACATGGTTTTACTTATTATAGTAATGCCCTTCCTAAC


GTTTCAGATTTGAAAAGAATCATGTTCTTAGCTTTCTATCTTGGAGACTATTTAAATGGCCTTTCTTTATTTAGAACTAACAATAGA


ACCTGGCCTAGAAGTCTCTCTGAATGGGGGCTGTGAGGTAAGGAGGAAACAATGTCACCGTGCCTCCAAAAAACCTCAAAGATCAGA


TTGTCCTAAGACAAGGAGAGTTTCTGGGGGAAATCCAGGAGGCACGACTGTGGAATAGAAGTGGCATTTCCTAGCTGACCGATAGCA


TTGAACAAAGCTTTGGGTCACTTTCTGCACCTTTGGAAATGGGGGTGTTAGTTCACAGAGCCGGGCATGTAGGCCTCTGCCAAATAT


TTGATATTGAGTTTGAACTCAATATTTGAGATGTATATCATGTAACTTGAGGGAATTTCCGAGGGCACCTGGGAAGTGATCGTCTCT


ATCCTTCATGGAGGTGAGAGCAGAAATCTACAGTCTCTGTGTGACTGCCCAGCTGTTTCACGTACATGCATGCCCACCCCCGTCCAG


GGTCTATTCTTTCTGTGGTGTGAGGACCCTATGTGTCCATGTTTGGGGAGGTACCCAGTACAGGTAAAGGGGTTGCAGGGGGCACAA


ATACTGGTGTGCTCCTTCTTTTCTAAGAAAACGTAATTTGAAAAGAATCGTAATTTGAAATTATTGATACCACTCATAATTAAGAAC


TTAACATTTTATTTACAGCTGCAAATAATTGGTACAGTCAGTAAACAAGAACTTTACATTTTATGTCCTCACTGAGGAAAGATAAAC


AGGAGCCCTACGGGAGCTTGGAAGTGGAGTTTGTACCTCAGCCTCAGCATCAGCATCCTAGACTGTCAGGCACTGGTGTGGTCCTTC


TGACTCTCTCCCCTCACTCCCCCACAAAGACGCATCCATCACTCAGTGCCACGTGAATGGCCACACCCCACTGTCCACCCACCATGG


CCCCCCATTTTTGCACCTCAAGATCACAAAACAGTTTGCAGAGGGTAAAGATGTGGGAGGAAGGAGATGTGGAAATGGTGGTGGGTG


CAGCCGGCAGCCAGGATGACTAAAATGAATCTCTTTGAAGTGTCTGGGTGGAAGGGAAATTTCCCCAGGGTTCTGAGCAGTTACCCC


AGGGCCTCATGCTCTGAAGCCGTATACCTTGTTATCTGCCTTAGCCAGAAGTCCCTTCTGATTGCACTGTGGTGTTATTTAAAGTGT


TTCCTGGTCTTGGTGTTTCACAGGCAGGAAGAAAGAGAGCCCAGAGTTTCATTTCCATGATTGGAAATGGTTTTCTTGCCTCAGTCA


CAGCCCCTCCCACTTCCCCTGCTGACCTCTTTAAGATGAGCGGATCTATTTCACAGGGCTGGGAGGTGGAGGGAGGTGTTAAAACAG


TGACTCCAACATCAACACGATAATGTAGTGTGTGTGTGTAGTGTGTGCGTGTAGTGTGTGTGGAGTCAAGCCACGGTTGCAAGGGAC


AGGTGATTATAAAACCCACGATAATCTACCTTTCAAGTTAGGAAAGAGGCTTCCTGGAGGTCAGGCAGAACATTGTTCACACGTCTG


GCAGTGCATTAATCACGAGCAATTCATTAGGCCTTAATGTGGATCTAATGAGAAATTCCTATTACTCAATGTTTGATTTGGGCTTTG


TTGGTTAATTATCAAATGGAACACCAGAGACTCCAAAATGTGATTATGAAGTGATCTTTAATTTTTAAAAGTCCTTTCTTGGGGTGT


AATATTCCATTAACAAACCTTAAGAATCAGAAGGCCCCAGTTTGGAGATGTGTAGCAACTGAATGTAATTACAGCCCCTTTCAGAGA


AAAGCCTCTCGCTTCCCTGTGATCTAAGGCCTTGTAACCCGTTCCCTGTTGTGTGTCTCTTTTGTCTTAGTTTTCTGTGTTCCTGGG


GATTATTTTCTTCCTGGAACTCACTGCTGGGGTGTTGGCATTTGTTTTCAAAGACTGGATCAAAGACCAGCTGTATTTCTTTATTAA


CAACAACATCAGAGCCTACAGAGATGACATTGATCTACAGAACCTCATAGACTTCACCCAGGAATATGTAAGTTCCAAGCAGGAGCA


TCTTTTCTCCCATAATGCCTTGTGTGCCTTTGCCAGCTGGAGACGGCCAACTGACGTTTCTGCCCAGTTTCTGGCTGTTTGCTTGTT


GGTTTGTTTCCTTTTCCATGTTCCACCGCTCCTGTTTCATCTCAAGGAGACATGTTCCGAGTTCACTTGCTCCAACTTGTGTTAAAT


TAGAGGAAGATATAATTCTTAACTAAAAAGGCGATTACCGCACCGTCCCGTTGTCAGCTTTTGAAGAAAATTGCTTTTATATATGTT


TAGAGTTTTATGTGATTAAATAAATTAAACGAGTTTTCCTTGCTCCTTCCCCTGTGCTATCAATAATAAAATTATCAGGGGGATTTG


TTTNNNNNNNNNNNNNNNNNNNNGAACTCACTGCTGGGGGTGTTGGCATTTGTTTTCAAAGACTGGATCAAAGGACCAGCTGTATTT


CTTTATTACAACAACATCAGAAGCCTACAGAGATGACATTGATCTACAGAACCTCATAGACTTCACCCAGGAATATGTAAGTTCCAA


GCAGGAGCATCTTTTCTCCCATAATGCCTTGTGTGCCTTTGCCAGCTGGAGACGGCCAACTGACGTTTCTGCCCAGTTTCTGGCTGT


TTGCTTGTTGGTTTGTTTCCTTTTCCATGTTCCACCGCTCCTGTTTCATCTCAAGGAGACATGTTCCGAGTTCACTTGTTCCAACTT


GTGTTAAATTAGAGAAAGATATAACTCTTAACTAAAAAGGCGATTACCGCACCGTCCCGTTGTCAGCTTTTGAAGAAAATTGCTTTT


ATATATGTTTAGAGTTTTATGTGATTAAATAAATTAAACGAGTTTTCCTTGCTCCTTCCCCTGTGCTCTCAATAATAAAATTATCAG


GGGATTTGTTTGTAAAGTTCCTCAGATATGCTCATCCAGATACCACATGCATGTAGTCCGAACCAAAAGTTCAGAGATTCGTAAAAC


CTGCTGCCCTCTAACAAGTGAAAAAGAAGCAGACCCCGCCTGCCACACAGGTGTCTGAACGTGACTGTGTGACTGACTGTTCCCATA


CTGTAAACAGGCAGCTGTCATGTCACTCAAAATGCTCGAGGAGCCAAGCGACACTGCCTCATTGACCATGGACTGACAGAAACTTGA


ACTCTTTCCCAAGAGTAAAAGGAGAATAAAACTGAGTTACTATCTAGTACGTATGGCTGTTGGGACAGTGGTCTCACCTTAAGCCCT


AGATGTTACCAGACTAAAGATTAGCAGGTCCTCACACACCTGCCCTGGAAAAAAATGAGTAAGCCGAGCGACCTTGGTTCCATGGTA


TCCATGGCTTTAATATTTAGAACAAGATAGGAGACTACACAGAGGCTCTGTGGACCAAGGTCTAGCTCTGAGTTGGGTAGGTTGCTC


TGGGATCACATTTACCTTCAGTCAAGAACGCCACACTGCATCAGCATTGAGTGGGTGTTGAGGTAGGCCATTCTTCTCTAGGTGCTC


AGCACTGGGCTGAGGTCTTAGTTTCACTCAGTGGCTTCTATCTAGAGCAAGCATCCTCAGGTGGTGTGAAATTGAGCCCTGTCTCAC


GTGCTCAGGCGATTTCCCTGTGCTGTTAGGTCATAATGGATGCAAGCTCTCAGCTTCCCGGGTATTCTCCCTGACTAGCTGGCATGA


CAGAGCCGGCGAGGCTTTACAGGAAACCTGTGGTGTCCAGCCCAAGCCCAGAGGAGCAGCTGAGCCTCCAGAACCTGTGTTTGCACG


CGTTCCTAAGAGCTGCCTGCTCTACTTAGCAGCACTGCTCTTTCATGTGATTCTGGTCTTCTGTTCTGGAGTTAAAAACATTTTGAT


GTAGCTGTTGGTCCTGAAAGCCTTAAAATGGCCACAAATTGGTTTTATTTAACTTAAGAAGCCAAGATGATCCAGTACAGAAGGAGG


CCATAGTCAGTCCCCATTTAAGATTTGAGTTGAACTGAATTTAAGAACTGAACTATAGGCTGGAGAGATGGTTCCTTGGTTAAGAGC


ACTGACTGCTCTTCCAGAGGTCTTGAGTTCAATTCCGAGCAACCACCTGGTGGCTCACAACCATCTGTAATGGGGTCCAATGCCCTC


TTCTGGTGTGTCTGAAGGCAGCTACAGTGTACTCACATACATAAAATAAAAAAAATAAATCTTTTTAATCTTTTAAAAAGAACTGAA


TTGAGCATAAAAATAAGTTCTTTTTAAAAATTTAGTGTAGAGATGAATATAATGAATAGTTAGGCCTCTAGTATTATAGAGAGGTGG


GTCTGCCTCATCCGTGTTTGACCACTGTAGCAATGGACATCAGCCCTGACGTTCACTGTCCTGTGAAGTGGCTACTGTTCTACTGTG


TTACCCACAGACCAGACCTCATCAAAGTGTCTACTGTTTACCTGATGCCACTTAAACACAGTGAAACTGTTTACGAACCATTAAAAT


AAGATCAAAACTTAAGCACAACCACAGTTGCCTCGTTATACGTTACCGTTGTTGCTAGTGTCTTGTTTTTCCTTCTAGAATGTTCTG


GTTTATCCTAGAACGTGACCGAGCCAAATTTATCGTGAGCCCTGCTGTACAATGTCCCATGCCAAACCATCTCTAGGAACCTTCAGC


CTACATCCCTTTGGAAGGCTTTCCAGGGCCCGTTTAGGTTAATTTTAACTTAAAACTAAATGTTGAGCCCCCGGACCTGTCTGGCAG


GGGATGGGTGTCATGGGGGTGGGGTGCAGGTGGCTGGTCACCCCACCTGAGATGTCCTTTCTAACTCTCTCCTGTTTGCTCTAGTGG


CAGTGCTGTGGGGCTTTTGGAGCTGATGATTGGAACCTAAATATTTACTTCAATTGCACAGATTCCAATGCAAGCCGAGAGCGATGC


GGTGTGCCATTTTCCTGCTGCACTAAAGACCCCGCGGTAAGAGCGACTGCTCACTGCTGCCTGCCCGCCGTGTGCCCCGTGTGACGG


CAGAGCCATTTCTGTCTCAAAACTCTCTTCTCACAAGCTCAGACCTGACTGTAGGTCCTAGAGGAGGCTGATACGCTCCAGTGTTCC


TAGTCAGGACAGGATGGCAGGAATTAATTTAGCCAGTGCTTGTTGTCTCCTATTCTGAGCCCTGGTGTGTTGTCTCACGGGAGGTGA


GAAAGGGAAGTCCCTTTCTGGGGAAGAAAATAAAACCCACCAAGGCCTATGGAGTACAAATGATTTCTCCCAAATAACAGGGCTGAC


AAGGGACAGAGCCGGGTGACTGTGTCTCTTGTCTCTCCTTATAATGTATGAGCCACCTCTCTGCAGTAGCTTGGATTTAGTAAGCCT


TTTCTTCTCCTCTGGTTTCTGGGAAGGGACTCAGGAGTAAAGAAGGCAGATGAGGATGGGGCGCTGCTTGAGGACCCACAGTGGCCC


GGAGGGTGGCATGGGGGTGGCTGCAGCGGCTGCCTTTTGCGGTTTTACTTTAGAAAGAAAACACGGAGTGCGTCCACAAGCTACTCC


TCTTTCCTACACTTCACATCGTGTGCATGGCTCACAGAATGAAAATGTGAACCGTCTGTATTGTAAGTGGAAAGCCAGAACTGAGTG


GTAGTGTGCCCCGTGTGGGGAGTGGCTACTGCCCTTCTGGGACAAGCCTGCCCATTGAGCACAGTGGCGCACAGTGGGTGCAGCGTC


CCACAGGCTCCCCCTCCTGCAAGGTTGGGGCTATGCGGCTCTCTCGCGAGGCTTGGGTTTTAGGATGTTGAGCTGCAGGCTGTGCAG


GCTGCTCTTCTGGAGGGCGCAACAGCCTGGGCTGAGCGTCACTGAGAACTGTGTCATCCTGCCTGTGACTCCTTCCTAAACTTCCTA


GCTTGCCTTCCTCCTCTGAGGCGGCTCAAGCTGCAGCAGGATATCCAGCCTGGAAGCCATGGTACCCAGCATAATGTGCTTGCTGGT


GGGGAATGTTTTACTATATACTTTTGAAGCTGCTCTAGTAAAAGCATGGCATTTAATAATAATAATTGTTAAATAATATTTGATAAT


TAATTTAATAATAATGTTTAATACTGTGCTCCAGTGCCCATCTTAGCTGGGCTTTCTGCTGAACAAGAATGAGTTTCAGTTTTTCTC


TTCCTTTCTTCCCCAGGAAGATGTCATCAACACTCAGTGTGGCTATGATGCCAGGCAGAAACCAGTAAGTGAAACCCGCCCCATGTC


TTAGCACATACGGATTTTTTGGAGGAGCGTTTGCGCATGCGTAAGGCTGTATCTATGACATTCTGCTCTCTTCCCTTGTAAAGGAAG


TTGACCAACAGATTGTAATCTACACAAAAGGCTGTGTGCCCCAGTTTGAGAAGTGGCTACAGGACAATTTAACCATCGTGGCTGGTA


TTTTCATAGGCATTGCATTGCTACAGGTAAGATGTGGGTCCTCCGTGCTAGCTCAGACGGTGGTGCCCAGAAAGACCTCCCCAGTCC


AAGATCTTTGCTTTGTCTCCTCGATGCCTTAGCTTCTGAGACACACTGTAGGTCCTAGAATCAGACTGGAACTATTGGGTTTGTGTT


TATTGAAGGCCTGAGTCTAGAGACAGAAATACCTTAGGAAGTCTTGCCTCCTTTCACCACAGCGGTGTTGATGGGTCCCAGGTTGTT


ATCTGGCATCCCATTGTTTCAAGGATTCTTAAAGGATTGTGTTGTGACACTTGGGGCAGACAAGGCTGCTCAGAGTGGGGACCCCAG


CAGCAAGGCCAAGCTCTGTGGAGTTGCACAAGGACGTGCGATATCTTTTGTCTCTCCAGACCAGCTCACCCAAGTGCTGGTGAGGAC


AGTCCCAGGAGCTGACTCTTCCTGTTCATAAGATGCTTTCTGTGGAGGGCCACGGATGGGTACATGGTTGAAGGAAATTGAAGAGGT


CTTAAGTAAATAGGAAGGCAAGCTGTGTCACAGATTATAAACTCAGTGTCGCTCAAGTGGCATCAGCAACTCATGGTGATCTAGAGA


TTCTGTGCTCTCCGTCTCTGTTCCAGCCTCCTCATTTAGTCATTGACTAGCTGGGCCTGAGTTCACAGGGAAAAATAAGAGCCCAGA


GTAGTCAAACACACTGAAAGAGAATGGCAGGATGAAGAATTCTGGTTTCCCAGTTAAAGCATACTACAAAGTAACAGGGTTCAAGGC


AGGCTTGTACGGTTGTAAAGTTAGCCATTTTGATAGATGAGATCGGATTACAGAGACAACTTTTGTGAGCTTTGTTTTGATAAGGGA


ATTGAAACTTTTCAATGGGGAAGGAAAAAAGAACTTTCAAGGATGAAGGAAAAACAAACAAAACAAAAAAAAAAACAAAAAACAGCT


TAGTGGTTCAGAGCACTGGCTGTTCTTCCAGAGGACCAGGGTTCAATTCCCAACCCCTACATGATAATTAACAACTGTCTGTGACTG


TAGTTCCAAGGGACCTGATGCCCTCTTCTGGCCCCCATCCACACTTTATGCATGTGGTGCACAGTCATGCCTGTAGGCAAAACACCT


ATACACATTTCAAAACAGGGGGAAATTTTTTTAAAAAGTTTTTTGACAGATGGTGCAAGAATACTGATTTTTCTGTCTAGAAAAGAA


AGGTGTTTAGACATCTATCCCATACCATATATAAACATAAACATAAACTAGATCAAAGACCCAAATCTAAGTGTGGAGTTCTGTATG


CCTGTAATGTAAGCCATTAAAAAAGGTTGTAGCAGGATAGCAGGATCGTCACTTAAGAGTACACAGCCAGCCTGGCCTTCACACTTA


GACCCTGTCTTGGTGTCAAATAATTAAACAAAGCTCTCTCAATAAAAAGCCAAAGCTGTGGGCTGGAGAGATGGCTCAGTGGTTAAG


AGCACTGACTGCTCTTCTAGAGGTCCTGAGTTCCATTCCCAGCAACCACATGGTGGCTCACAACCATCTGTAATGGGATCTGATGCC


CTCTTCTGGTGTGTCTGAAGATAGTGATAGTGTACTCACATTCATAAAATAAATAAATATTTTTTTAAAAAATGCCAAGTTGTGACA


GTCTAGAAGAAAACATGGTATAAATTGGTGATTCCCTTTGTTTTGTCTTGCACAAAGAGTTTCAGGGGAAAAAAAAAACCATCAGAT


GAAGGAGAAATAATGGCACTTCATCAAAATATAAAACTGAGGTTACCCACAATAGGAGAAAGTATTTTTGAGGAGTTACGTGTGTGT


GTGTATGCATGTATACATAATATATATATATATATATATATATATATATATATATATATATATATATATCTTATAGGAAGCAAGAAA


AAAGGCTAGCATGGGCTATCTACCAAGGTCCGGTTTAAAAAATGAACAGAGTACTTAGACATTTCTCCAGCAGAGACAGGAATGTCC


CATGAAAAGATACAGCATCACTTGCCATCAGAGAGCTCGCCAGAGCTGCAGTGAGGTGACCATTGCACACGTACACCCACTCGGACA


GCGGGTGTTCACGAGGATGGAGGATGGATCACCCTCAGCTTGCTAGAGTGGGGGAACAGAAAGGGCCCGGCTCTTTGGCAGATAACA


TAGTTACCATGTGACCTTACAGTTTTTCCACAAATGCCAAAGGAATGAAAAGCGACACTTACCAAAACATTGGCACACACGTGCACA


TAGCAACAAGAACTGGAGACGCTGAAGAATCCATCCATGGATTTTTAAAGACTGTAGAACGGCCTTACGGTAGGGTCGGTAGTCAGC


CATCAAAAATGCAGGCATGGGCTGTGCTGCGCATGCCTGCAGTCTCAGCCCCAGGGAGGCAGAAGCAGAGGCAGCAGAAGAACTTAG


ACTGTACAGGAAGGCTCTGCCTCAGAAGCAAGCAGACACCACAAATAGAACAGACTGGCCAGGTGTTTGTTTGCAAGTCACCACAGT


TACTTTCTTTAGCTGCTTTTGTATAGAACCCAGAGCTTGTGTCCCTTGCTGGCGTCCTGCACCACATCTCCCCCACTTCCATCTGAG


TCAGAACTCTGAATCAGCCACTCACCGCTTCTTCACAGTGCCCTGAGGGTGCCCACTTCTCAGCACAGCCTGAGTCCCTGACTCAGA


AAAATCACCCACCTAGTCAGCCTGGAGCTCTGCCTCCCCCCCAACCCCCACTGTGACCTTGCTGATGGGGAGAGGGAGGAAGCTGCA


GAGCCAGTGAAGTGATGGAGCCTTCCCTGAAGGTCACAGACCCAGCCTCAGCAGGGAGAACAGGGTGCTGAATGGATCAGTTGGTAC


CCAAGCCAGAAAAGCTGGTCACCAACAAAAATGTTCCCTGCATGTGTGATTTTATTAAGGCTTATTACCTGGCAGAGCCCATGAGAT


CCATACAAGGAGTGGGTTGTGACCCACCTGTGCAAGATAAGAGCCCAGCTGGGCTTCAGCCTGACATTTCCACAGACACGTGTGGTT


TCCCTGGTCATGAACACAGCGCATGCGTGTTAAGGTTACCTCAGCTCTCCTTATCTTGTGTAAAATGTTCACTAAAATTCTTTGATT


TGTACCCTGTAAATAAAGAAAACTCATAGTTGGGTCCTGAAGGGTTGTAGCGCTGTGATTGAAACCTTGCAGAGGAAAGAAAGAGAG


GTTTGTTCAGACCCGTGGTGGGGGAAGGCATAGAGGTCATAGCAGCTCGGAGACAGATAACTCCTTTGACAGCTGTCCCTAGCAACA


CACACGTCTCAAATGTCCTACAACCTCCCAAAACATTGCCACTCACTGGAGACTGGGCGTGCACACCATGAGATTGCGTGGGCTTTT


CACATTTGAGCGGTCACCGTAGCAATGGACGAACCCAGAGATGGTTTTGCTCCTTGAGAGAAGTCACAGGAACCACATGTTGTCCGA


AGGCATTTTCATGAAATGTGCAGATCGGGCAGATCCATAGAGGGAGCAGGGAGGTGAGAGCTTTCTAGGCCATAGGGAGGGTTGGAA


ATGACTTCTCGTGGGATAGGGTTAGCTTAGCGGGGTGAGCAGCTCCTGCATTTAGTATTGAAAATATAAAGTCATGCTAAATCTCTG


GATTTTTTATTTTCTATCTCTCTTTCGCCACTCTTCCCCCCCCCCCAGCCTTTTTTTAAAGACAGGTCTCATGTATCCCAAGCTGGC


CTCAAACTTGCTCTGTAGCCAAGGATGGCTTTTTACACTCCTGCTTCTTCCCACCCAAGGGTCGGGATTATAGATGTGTACCACCAT


GCCTGGCTTTCTATGGCGCTGGGGGGTAGAACCCAAGGTTTTATGTATGTGAGGCAAACGCTACCGACTGAGCTACATCTCCAGCCC


CCAAATATCCATTTAAGAATCAGAGGGGGTGGACCTAGTGGCCAAGGAAAAGCCAATAGCATTTGAATTCTGCTGTCTAACTTGGTT


TCCTTTCCCCCTTTTTTTTTTAGATTTTTGGGATATCCCTGGCACAGAATTTGGTGAGTGACATTGAAGCTGTCAGGGCTAGCTGGT


AGACCCCTGCGACCACTGCTGTCAGACACTGGACTGATCCCCCCTCACTGACTGACCCTCTGTGCGCCGGCCGGCTGATGGCGGGCT


GTAGAGGCCTGGTCACAGGCCTACAGTCTCACCTGATGGAGCTGCCAAGAACTTAACTTTCTGTGGGGGTAGAACTGGGAAATGCTG


CTCACAGACGGAACTTGGAAAAAGAAAAACAAAACAAGTGCGCAACTTGCTGAGTCAACGTGCAGTGAATCTCTACTGTAGCCGTGG


ATTGGTGGTCGGATGGATGCTACCAGAAGGGGGAAGGGGGGAGGTTGGGCACGGCATGTACTTGAATTTTTGGAGAATACAGTGCTG


TACACATCTTGGCTAAAACTTGGGCCCTTAGCCGTCAGGGCCAGGTGTCTTGAAATCTCTCAAACCCTTTGCATCTGTCCTCCAGAG


AAGAAACCAGCTGCCCCCTGTGTTCAGATTCTGAGAGAGGTGGAGCGGGTCACGATACAGCATGCGCCCTTCATCCTGAGTTTGCCC


TTAAGAGAACTGGGCGTTTGCAGTAAACTAGGGTGCCAGAGGCTGAGCTCCACATTTCCACAGGACTGCTCTTTCCTCTGAGTGGCC


AGCCCGAGCCTGAGCTCTGTCAATGACATCCAAGGAGAAAATGAGGTTAATGAGAGACATTAATTAAACACTCCCTCACCCCACCGC


ACCAAACCAGTTGGGTTCTTCTGATATTCTGGAATACTCTGGGCTATGTTTTATGTTTTATTTCTTTTTTAATCGGTTGTTATTTTG


GTTCTTTTTTTTTTTCTTTCTTTCTTTTTTCTTTTTGTCTCCCAAAGGAGGCTATGACACAGTTCTCTTGGTTTCTTATTCAGCTTG


AATAGTAAGTTTTTGTAGACTTGTCACCTGCATGTACTGTAACCCCACCCCCACCCCCAAATCCACCATGTTCTTTTCAGAGAGACA


TTTGAGCGTGTTCCTTAGTGTTTATGTCCTAGGTATCCAGCCTTGAGTGGTTGTGGAGTGTTGTCCTAGCCGCATCTTTGTATGCCC


CTCAGGCTCTCTGTCTCTCCTGGCATCCAATTCAGCTTCTGTCCATTCGCCATTGAGTGGTAGAAAAGCCCAGCTCCAAAGCAGGGT


TGACACAGTCAAAAAGCATTTCATGAGGTTTTTCTTTCTTTTCTTTTTCCTCCCTTTTTGCAACTTTAGTTTTGTCGTATATTAAAT


AAAAAACCAAGCCTAGTATAGTGCATGTGCTCGCTGAGGTGACCTCGGGGTGGTTACAAAGCACAAATATTTCAGGGGCTGCGCCGA


AGCCCAGCCAGGGTTCAGTGACGCTAGGTGGAAAACCACCTTCAGGTTCTTCTCCTGCCTCGTGCCCACTGGGAGGGTGGACTTTAG


CCCCAGATCCCCCCACCCCCAGCTTGTGATAACCCCTGGATGTTGCTTTCACGGGGAGCAGATTTAGTTTGTGGGTTTGCTGGGAAG


GCCCCAGCCTCTGCGAAAAGCAGCTCCCCATTGGCCAGCCAGCAGTCTGCGTCATGCAGCCCGGTTTTCCATTTCCGCAGCACGTGT


GCGTTGCCGTGGCTGATGGGCGCTGTCTGCTCAGAGGGAGGTCAGGCACTCCTTGGGTTTACGTGGCTCTGCATGTTTGTATCGGTG


TCTGTTTTTAGGTAGAGATAGTCATTCCATACGTGGATGCGAGGTCACGTGACTTCACCCCTGTCCATACCACAGCCGTCGCTTGTG


ATGTCCTTCAACATGGACACTCGTGCTCTCGGATTGGCACTTCTGTCTTCTTTATTACCTCATTCTCCAGTGAACTGCATCTGGCCA


ATTGATTCAGAATCAGACAGGATCCCCACCCCGTGGCACATCCAGTGAAAGCCAAAACACAAGCCCAAGCGAGTTTTAAATTTTAAT


CACCCTTTATTTTTTACACTCGAGAGTGATTGTAATAAAAGCTGTCATTAATAAACTCGGTTCTACCT





MOUSE mRNA SEQUENCE: mR28-002.1 (Seq ID No: 50)


CGCGGCATGAGCCCCGCGTGCCCCACTGCTCGCCGGGCTGCTCCGAGCCGGGGTGCTCCGGGGCTCCAAACTCGGGCTGGCGGGGCA


AGTGTCTTCATGAACCCAGAGGATGTCCGGGAAGCACTACAAGGGTCCTGAAGTCAGTTGTTGCATCAAATACTTCATTTTTGGCTT


CAATGTCATATTTTGGTTTTTGGGAATAACGTTTCTTGGAATCGGACTGTGGGCGTGGAATGAAAAAGGTGTCCTCTCCAACATCTC


GTCCATCACCGACCTCGGTGGCTTTGACCCAGTGTGGCTTTTCCTTGTGGTGGGAGGAGTGATGTTCATTCTGGGGTTTGCAGGGTG


CATCGGAGCACTTCGGGAAAACACCTTTCTTCTCAAGTTTTTTTCTGTGTTCCTGGGGATTATTTTCTTCCTGGAACTCACTGCTGG


GGTGTTGGCATTTGTTTTCAAAGACTGGATCAAAGACCAGCTGTATTTCTTTATTAACAACAACATCAGAGCCTACAGAGATGACAT


TGATCTACAGAACCTCATAGACTTCACCCAGGAATATTGGCAGTGCTGTGGGGCTTTTGGAGCTGATGATTGGAACCTAAATATTTA


CTTCAATTGCACAGATTCCAATGCAAGCCGAGAGCGATGCGGTGTGCCATTTTCCTGCTGCACTAAAGACCCCGCGGAAGATGTCAT


CAACACTCAGTGTGGCTATGATGCCAGGCAGAAACCAGAAGTTGACCAACAGATTGTAATCTACACAAAAGGCTGTGTGCCCCAGTT


TGAGAAGTGGCTACAGGACAATTTAACCATCGTGGCTGGTATTTTCATAGGCATTGCATTGCTACAGATTTTTGGGATATGCCTGGC


ACAGAATTTGGTGAGTGACATTGAAGCTGTCAGGGCTAGCTGGTAGACCCCTGCGACCACTGCTGTCAGACACTGGACTGATCCCCC


CTCACTGACTGACCCTCTGTGCGCCGGCCGGCTGATGGCGGGCTGTAGAGGCCTGGTCACAGGCCTACAGTCTCACCTGATGGAGCT


GCCAAGAACTTAACTTTCTGTGGGGGTAGAACTGGGAAATGCTGCTCACAGACGGAACTTGGAAAAAGAAAAACAAAACAAGTGCGC


AACTTGCTGAGTCAACGTGCAGTGAATCTCTACTGTAGCCGTGGATTGGTGGTCGGATGGATGCTACCAGAAGGGGGAAGGGGGGAG


GTTGGGCACGGCATGTACTTGAATTTTTGGAGAATACAGTGCTGTACACATCTTGGCTAAAACTTGGGCCCTTAGCCGTCAGGGCCA


GGTGTCTTGAAATCTCTCAAACCCTTTGCATCTGTCCTCCAGAGAAGAAACCAGCTGCCCCCTGTGTTCAGATTCTGAGAGAGGTGG


AGCGGGTCACGATACAGCATGCGCCCTTCATCCTGAGTTTGCCCTTAAGAGAACTGGGCGTTTGCAGTAAACTAGGGTGCCAGAGCC


TGAGCTCCACATTTCCACAGGACTGCTCTTTCCTCTGAGTGGCCAGCCCGAGCCTGAGCTCTGTCAATGACATCCAAGGAGAAAATG


AGGTTAATGAGAGACATTAATTAAACACTCCCTCACCCCACCGCACCAAACCAGTTGGGTTCTTCTGATATTCTGGAATACTCTGGG


CTATGTTTTATGTTTTATTTCTTTTTTAATCGGTTGTTATTTTGGTTCTTTTTTTTTTTCTTTCTTTCTTTTTTCTTTTTGTCTCCC


AAAGGAGGCTATGACACAGTTCTCTTGGTTTCTTATTCAGCTTGAATAGTAAGTTTTTGTAGACTTGTCACCTGCATGTACTGTAAC


CCCACCCCCACCCCCAAATCCACCATGTTCTTTTCAGAGAGACATTTGAGCGTGTTCCTTAGTGTTTATGTCCTAGGTATCCAGCCT


TGAGTGGTTGTGGAGTGTTGTCCTAGCCGCATCTTTGTATGCCCCTCAGGCTCTCTGTCTCTCCTGGCATCCAATTCAGCTTCTGTC


CATTCGCCATTGAGTGGTAGAAAAGCCCAGCTCCAAAGCAGGGTTGACACAGTCAAAAAGCATTTCATGAGGTTTTTCTTTCTTTTC


TTTTTCCTCCCTTTTTGCAACTTTAGTTTTGTCGTATATTAAATAAAAAACCAAGCCTAGTATAGTGCATGTGCTCGCTGAGGTGAC


CTCGGGGTGGTTACAAAGCACAAATATTTGAGGGGCTGCGCCGAAGCCCAGCCAGGGTTCAGTGACGCTAGGTGGAAAACCACCTTC


AGGTTCTTCTCCTGCCTCGTGCCCACTGGGAGGGTGGACTTTAGCCCCAGATCCCCCCACCCCCAGCTTGTGATAACCCCTGGATGT


TGCTTTCACGGGGAGCAGATTTAGTTTGTGGGTTTGCTGGGAAGGCCCCAGCCTCTGCGAAAAGCAGCTCCCCATTGGCCAGCCAGC


AGTCTGCGTCATGCAGCCCGGTTTTCCATTTCCGCAGCACGTGTGCGTTGCCGTGGCTGATGGGCGCTGTCTGCTCAGAGGGAGGTC


AGGCACTCCTTGGGTTTACGTGGCTCTGCATGTTTGTATCGGTGTCTGTTTTTAGGTAGAGATAGTCATTCCATACGTGGATGCGAG


GTCACGTGACTTCACCCCTGTCCATACCACAGCCGTCGCTTGTGATGTCCTTCAACATGGACACTCGTGCTCTCGGATTGGCACTTC


TGTCTTCTTTATTACCTCATTCTCCAGTGAACTGCATCTGGCCAATTGATTCAGAATCAGACAGGATCCCCACCCCGTGGCACATCC


AGTGAAAGCCAAAACACAAGCCCAAGCGAGTTTTAAATTTTAATCACCCTTTATTTTTTACACTCGAGAGTGATTGTAATAAAAGCT


GTCATTAATAAACTCGGTTCTACCT





MOUSE PROTEIN SEQUENCE: mP28-002.1 (Seq ID No: 51)


MSGKHYKGPEVSCCIKYFIFGFNVIFWFLGITFLGIGLWAWNEKGVLSNISSITDLGGFDPVWLFLVVGGVMFILGFAGCIGALREN


TFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDLQNLIDFTQEYWQCCGAAGADDWNLNIYFNCTDSN


ASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDI


EAVRASW*





MOUSE PANTHER CLASSIFICATIONS


FAMILY (SUBFAMILY)


TETRASPANIN-RELATED (TETRASPANIN TSPAN-5)





BIOLOGICAL PROCESS


Cell adhesion (2.29.00.00.00)





MOLECULAR FUNCTIONS


Cell adhesion molecule (1.05.00.00.00) > Other cell adhesion


molecule (1.05.99.00.00)





MOUSE GENE ONTOLOGY


No Gene Ontology





MOUSE PROTEIN DOMAINS (INTERPRO SIGNATURES)


IPR000301 (TMFOUR)


IPR000301 (TMFOUR)


IPR000301 (transmembrane4)


IPR000301 (transmembrane4)


IPR000301 (TM4 2)


IPR000301 (TM4 2)





HUMAN GENOMIC SEQUENCE: hD28-002 (Seq ID No: 52)


CGCACGGACGCGGGCGCTCGCTTTGTGTTCGGGGCTAGCGTCGGCGAGGCTTGAGCTTGCAGCGCGCGGCTTCCCTGCTTTCTCGCG


GCCACCCCGGCTCCGGCGGCCTCGGCGCGCGAGGGGCTGGAGGTGCGGGAGCCGCTCTCCGCCGGTCGGTCCCCGCGCGGCTGAGCC


CAGGCCGCCAGCGCCGCGGCCCCGTGCGGTGTCCCTGAGCTCCTGCTCCCCGCCGGGCTGCTCCGAGCAACGGTGCTTCGGAGCTCC


AAACTCGGGCTGCCGGGGCAAGTGTCTTCATGAACCCAGAGGATGTCCGGGAAGCACTACAAGGGTCCTGAAGTCAGTTGTTGCATC


AAATACTTCATATTTGGCTTCAATGTCATATTTTGGGTAAGTTGGAGCGCTCCTGGGATTCCAACTATTGTGGCCGATCGATTCGCG


ACGATTTCCCCCACGTTGTTCGTTGCCTTTACTTTTCGCAGCCCCGCAGGCGCTTGCCGGAGCAGCATAGAGGCATTCGCCTTCCTC


CTTTCCAGCTTGCGCGTTGGAGAGATAAACATTTAATCCTTTCGAGGAATGGGAAGAGGTGAAAAGAGAAATCGAGGCGGAAAGGGG


GCACCGAGGCCTTCTGGTGGCTTTTTGAGGAACGAATAGCAGGGATGCAGATAAAAGAAAGGGTTCGGCAGTTTGAGAAATGAGCAA


CCACACGAATTGGATTTGCTCTCGGTGGGATATAGATGTTGGGCAGAGCGTGGTGTCATAATAGGGAAGGCTAATCGGGCACGGCCG


ACCCTGAGGTCCACCTTCTAACAACGATCTGATTGGACGAGGGCTTGGCTCCGTGTTGCCGCGGCTGGTCTGTGCCATGCTCAGCGT


GTATCTTCTTGCACCATCTCGGGCTTTGTGTAGGATGCAGATGCCGTGGTATATGGTCCTGTAATTGCACGTAAATAACGTTTCCTG


CACGCTCTCCTCTTCAGCTGGAAAGCGCTCCCTGTGCGTAATGGACTGGTCAGTGGGGGTGCGGGGTAGAGGGATTTATTTGTATGT


ATATATCATCGTCAGGATAATAAGTCACCGTCAACATATATTTCAGTGTGTTCCTGCCCCACGTCCTCATTTTTAAAGGAGTGACAC


AGAGCGGGCCGTTTGGGGGAACCTTTGTAGAAATGCAAAGGAGAAGGTGTGCGAGGCATGTTTTATTGGGGAACCGAGAGAGCAAAT


GCTTTAACACAAGATTCAAATGATGCTCTGCTTGGGACTGCAATGTGTTGGGAACCTATTGTAATTAGGCTGGGACGCCTACTCTTT


TTGTTTGTTTGTTTGTTTTGATTCTTTTCCTTGATCTGGCAAACGTGTTCAGCAGCCAGACAAAGAGTTCTCCAGGACAAGGGGAAA


ACGTTGGTTCAAAGACCATGTTATTTTTCTTCCCCTTCTCATCCCATCTCATCCTCTTCCTCAGTGGGCACCCGCATTTCCATAGAA


AGTAAAGATGGTGGCTGTCTGGGTAGGGGGTTCTCTAAGTTGCTGTTCAGTGTGAGGTAAACAATGCTCCAACTGCAGGATCAATAA


TTATCCACAGCAGTCTGAACACGGAATGTATTTATTTGAATTCTCCTTTAATTTGGGCTGTTTGCTGTACGTATATACATCTGTGAG


AATAGTTGTCAATACGGCTCTTCATATTCTTTTTTTGTACCGCACTCTTACCAGGTTATTTTATTTTCTGTTTTCTATTATAATACC


TTGCATTGGTCATGTATGTTTTGTGAGGGGAAATGCAAGGGATTGGAGACCACTTTCCGTGTCAGCATGTCATCTGTCTTCAGGACT


AATAAAGATAATGAGGGGACACATGAATGGATGTCATATCCGATCATTCCACAGGCAGTTTTTTGCCAGTGTTGTGCATGATTCCCG


GGAGCAGTCACCCACCTCCCTGCAATTAAACACTGCTACAAGTACAGGAAGAAGGAATTATTTTCTTTCTTTGCCCCTTCTCCATTT


GTGAAAATGTTTAAAAGTGGTGGGTAGCCACGGTTTTGAGTAAGATATTCTGATTTGATTGGAACTTGAAACTTTGTGACTTGGAGA


GGCACGGACTACCGAACTGGGACTGGTTCTTTTTGGGGTAGTGAGTTCAGGCCTCTTGTTTCTACTTGAACATTTCTAAAAGTTGCA


CATTTTAGCTACCCAGCAACAAAAAGCACCCAGGGACTTTCTCTGCCGTTTCCTAGCAGGGGGTGGTAAGGAAATAAAAGGATTTGG


GTCTGTTTCCCTGACAGTTTGCTGTAATTCTGTGGAGTGCATAGAGACAAATTTAGCCCTTTCTATGGATTAGGTTGCAGCAAAACC


CCTGGAATTGTAGAGAGCTTCAAAGAATTGCAGAGTGCTTGCTTGGAGAGGTCCAGAACAGAGCCGCATGTTTTCTGATTGTGAAGG


TCTTCATAGGTGGGTGGGTGAGTATGGGAAGCCTGAAAGGAGACCTAGGCTATGGGACTAAACTAGCTGCCCCAGGCAGAATTGTTA


AGTGAGTGCCTTCCTTATGAGGGCCCTTCACTTACCCTGCCTCTTGCCTTCCCTTCCTCTCCTCTCTGTGCCCAAAGCCTTCCTCTC


AGATACTCCCTCATACCTTTCCTATCCTGCTCTCTGCCTCAAAATTACCCCATATTTAAATTTCCTGCTTTATTGTACCATGGTCTC


TAGTGATGATGAACAGAAAGGCAACCATATGGTTTTGGTTAAAGTAATTCAGACTAAGATGTTAGTGACTGAAAAGCTGGGGTCAGT


AGCTTGGCAGCTTGCTTCTGAAAAGTTACACACCTCTGCTCTCTACAGAGTCACCAACCTGTCTGTGATTGCCAAAAACAGCAGACT


CGGTGCTACTCCCATACAATTATGAAGAAGAGATTGCCAACAGCATGGTTTCCTAATTTTCATTTTCACACTGAACTGCTAGACTAC


ATTTGACATACACTGGTGACATTCAAAGGTATAGTTCTGGTAAAATAAAATTGAACATATGGTGGCACCAGCACTGAGAGCTTGGTT


CTTTTCCTGATCAGCAGTTTGGCTCTTCATCAGTTAACTGCCTGGGCCTCAGTTTCTCAGCTGTTAAATTGAAGGAGGTGGATGAGT


TATAACGTTCTTTCTAGTTCTTACACAGAATGAGTTTCTTGAGTTCCAATATGCTGGAGAAGAAAAATAGAAGAGTTTGGCCACTAA


TTTATAACAGAAGTAGTATATACCAGGACACGTGATAAATTATAGACATTTTCTGTTAGGGAGACTTGTCTGAAGACTAGTTTTATT


ACTTTCATTTCTTCCTCAAAGATCCTTTCATAAAAAACAAACAAACAAAAAACAAAAAACAAAAACAAAAAAAAACCAAGGCTGGGC


GCGGTGGCTCACGCCTGCGATCCCAGCACTTTGGGAGGCTGAGGTGGACGGATCACAAGTTCAGGAAATCAAGACCATCCTGGCCAA


CATGGTGAAACTCTGTCCCTACTGAAATACAAAAAACTAGCCAGGTGTGTTGGCGGGTGCCTGTAGTCCCAGCTACTCGGGAGGCTG


AGGCAGGGGAATCACTTGAACCCGGGAGGTGGAGATTGCAGTGAGGCAAGATCACACCACTGTACTCCAGCCTGGCAACAGAGCAAG


ACTCCGTCTCAAAAAAAACAAAACAAAGCAAAACAAAAAACCTTTCACTAATTTCTTCTTGGCTTGTTCAGTTCCTGGTATAGTGTC


CGTGCTTCTCTCTCCCCACTGTGAATCTCAAATGTAGTCCTGTGAGTCATTAAATATATTTTTATTATTAGAATTACAGCTTCATGT


ATAAAATCTGAATCCTTTTATATAACAGTTGTAATGACATTCTGAGTAACAAAGTCAACATCTTGTACAGATTCCTTTCTCATTAGT


TATCACAGGCTGGTGGGGGAAAACTTGTTTCCTCTGTTATATATTGGAACAATTCAAGACAGAAGGGAATTGATTTTATTGAGGGTG


TCACCGTACTGGGACATTTCTCAGAAAACCCTGAGACTGCTTTGGGTTTGGGGGAGGGAGAAGAAAGAGGATTTTGTTTTAAAGTCA


TTTCTTTGGGGTACCGAACACCACATCCCATCACTCATCATTAATAGATGTTTTGCCCTTTTGGATTCTGGCTTTTAACTGTTTTGG


ATTCTGGATACTTAACTGTTCCCAGGCAAGTAAATTGATCTCAATATTCTGGTTATTTATTGCTACATAACCTCCAAGCTTAGTTGT


TTAAAACACAGTTGTTTATTATTATAGTTCACAGTTCTGTGATTTGGCCAGGCTCATCTGGACAGTTCTCACTTGGGGTCTCATACA


GTTGTGGTGAGATGTAGTTGGAGTTGGACTTACCGGAAGGCCCTCTGGGCAGGATGCCTGAGATGGTATACTCATATGACTGGAAGC


TGATGCTTGCTGGGAGCTTAGCCAGAGTTGTCACTGGAGCACCTACCTACACGTGGCTTCTTCCTGTCTCTAAGTCTTAAAGAAGCT


TCCAGCCAGTTAAGGTTCCACTTAGAACTGGCAGTGCCACTTTTATCTATTCCATTGGTTAGAGCACTCATGCAGACTGCTGAATTT


CAAAGGGTGAAGAATTAGAAGCCACCTTTTGATGGAGAAGTGTCAAGGTCACATTGCAGAAAGTCATGTAGGTTGTGGCCATCTTTG


AAAAATATAGTCTACTGTATTAAGGCACTGAGCCTTAATTTCTTGTTTATAAAGGAAAGATAACATTAATGGTGTTGTAGTTTTAAA


GATTCAGTGAGATAATGTTTTATTCGGCATAATATCTCAATATTTAACAAATAGTGAATATCATTACTGTTGTTGTCTCCAGATTTT


ATACTGGTTCCATACAGGGCTATAGAACTTCTAGAATGCCTTAGTCTAGTACTTTGGCATCATTACTACTAGGTAATGATAATACCC


TTAAGATCTGCCAAGAAGATGAGGCAAATGGATTCAATAGATTTTATAGTGACTTGTTAGGAAAGAACTCAATGGAAACGGTGGAAT


GATTTGGGAGAACCAAGTCATTTTTCTGTTTTCTTTGCTACAAAGGATTAGAAAAGCCTCAGTTACTTGAGGCCAACTTTCTCTTTT


GATATGCTTTCAGATATTACCTTGTGTCTTTAAGTGCAAGTTTATCCAGGGTTGATGGCAGGATCTTGCCTCTAATTTGCTTCCACA


GGGCTTAATTCAGAGAGGAGGGAGACTCAGGAAACCTTGGGGCGGTGGGGGAGGGGGGGCATCAAGTAGGAAGCTTTATCTTATGAT


TCACTATAAATTGCAAGATGTTCTGGAATGATGATACATCAGCAGTTTATAAGTCATAATTTTTGTTTTAATTTGCTAGACATCTGT


TAGCTTCGATGGCAACCATATGGGAATCTAAATTGCGTTTTGAATTACAGGGAGATGGTAGGAAGAAAGCTAAATATGGTTATGAAA


GTGTCATATGGGAAAAGTGTAAGAAAGGTATAAAGTGGGGAAAGTAATTGAATATAGGCTTGCTTAGTGTGGCCACTCCCTCTGTGG


GGCAGTATGAAGGCGCAGAAGCATTCTCACTTGATATACTCCGCAGATTGAAATGAAGCCAAGTGGGGAGAAGTTGGAAAACCAAAT


CATGTTTCAACCACCATAAACTTGCCAAAATGTTGCACTCATTTACATGGGTCACTTTGTTTTAATGTCCACAGTAATAGGTAGTCC


CTGGCAAAAGGTGAAAGCAATCTGCATTTTTAACAGAACTTTTCACTAATGATGTTTTTCTTGTAAGCACCCCAAAGAGTCTTCCAA


GAATATTATATCTTTGTGACAGATGAAGAAATTGGAGTACAGAGATGTGGAGTAACTTTTGAGGTGTTGAAGAGCATGTCAAGGTTC


AGTTTCAGAGTGTTAAGTCTCTTCCGTAATGATAGCCCCAGCTTTTTGGGTGGAGACTTATTTTAGAAGATGCTTGTTATTCTAAAA


TAAAACATCAAGTAAGTCATTTACATCTGTTCATAATCGAAAAGTGATAAAGTTTTTGCATATGCCACAATTAACACCACCCACAAG


CACAAAAAAGTTAGGATGAAAATGTTCTTCAAGAATATGGTGGAATAATTGTAGCCTATTGAAAATTCATAAATGAAAATTGGAGTA


TTGTAGACAGCATTCTTGAATCACATGTTTGTTTCTGTGTGTAATACTGATGACTGTCTTAAAATTTCTAACTTCCAAATAAATCAT


ACTCCACTGGATTATAAGGGCTTCAAGTGTGGGGGCTGTCTCACTTTCATAAGCCCAGTGTCTTGCGCATTGTCTGAAACACAGTAG


ATGTTTTGATAAACGTTTGGGCCAGGCTTGGGGGCTTACACCTGTAATCCCAACACTTTAGGAGGCTGAGGCTGGAGGATGGCTTGT


GCCCAAGAGTTTGAGACCAGCCTGGGTAACATAGTGAGACCCTATCTCTACAAAAAAAAATTAAAAATTAAAAATTAGCTGGGTGTG


GTGATGCGTGCCTGTAGTCCCAGCCACTTGGGAGGCTGAGGTGGGAGGATCACTTGAGCCTGGGAGGTTGAGGCTGCAACTGCACTC


CAGGGTGACAGAACAAGACCCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAGTATGTTGAAGGAAAGAATTACAAAATCATCAGA


AAGTACGTAGGAATCATCTCCTCTAACTTCCTAGTCAGTGAAGCATTCTCCATTGTATCGTGCCTACCTTTCTAAGCATGGATCTGT


TTTTGGACCACTTTAATTGTAGAGTTTCATCTGTTCAAACTAGATGTTATCTGTCTCCCCATCATTTCCATCCTCCTAATTTACTGT


TCATTTAAAATTTTTATTTGGAAACATTAAACCAATAGGAAAATTGCAAGTAGTATAGAGAACCTGTTTTTATCCTGTTTGAGAAAA


AGTTGCCAGCATGTTGGCTATCACACAAACAGTTGAGTATGTATTTTCTGTAAACTGGACTATTCTCCTAGATCACCACAGTACAAC


CATGAAAGCCAGGAAATTACCAATGATACATTAACACCATTTAATCCTTAGATTTCATCCAAGTTTCCCAGTTGCTCCCATAATGTT


TTAAAGCAAAAGAATTCAGGTCAGAACCACACTTTGTATTTAGTTACATGTTTTTAGTCTCTTTCAGTCCTTCACTATCATGCTCTT


GATACTTTTGACAATTATAAGCCAGTTATTTTGCAGAATGTCCCTCAGTTTGTGTTTGTGCCATTTTCACAAGCTTAGATTCAGGCT


GTGCATCTTTGGTAGGAATAGTACAGAAATGGTGCTGCGTTCTCATTGTACCCTATCAGGGTGGCATTGATTTCTGTTTGTCCCATT


ACTGATGATGGTCACTTGATCAAGGTGTTGTCTGCCAGGCTTCTCTACCATATAGTTACTCTTTTCTCATTTGTAATTTATAAATGT


TTTATGGCAAATTACATTGAAACCATGTAAATAGCCTATTCCTCATCAAATTTTCAATCTGTTATTTATTTATATCAGTAAGAACTT


AGTGTCTTCCTTTTTTCAGTGTGGTTTAATGTTACTGTCATTACTTTATTTAAAATGGCCCTAGGTTTGGCCAGTGCAGTCTTTTCA


CATTGGCTCCTGTGCTCTTTTAACTCCCATCAGTCTTTGAGCACCATCTTGCTCTCTGGCAGAATAAGATGTTCCAAACTCATTTTG


TGATTTACCTGTGTCATCTTTTGTATCAGACATTTCTCCAAGGAGCTATTGAATGGAGAATGGAATTTAGAAGCCAAGATCTGGTTG


CTTGGTGTGCTCATTGCTATTAGGGTGTTGCTACTCTGTGTATATACAGACACACATGTACATCTGTAATTCTGTATCTATGTACTT


TTAAAACCATGAGTTTACAGTCATACCTTAAATTCCTGTCTGATACCACAGGGTTTAGTTTTTCCTCTCCATATTTTATAACTGCTT


TATTTGACAGTGAGATTCTTGGTTCGCATTATTCTTAACAGTTTACTTATTTGGTAAATCTCCCCATATGTAACCAATCTTCTGCAG


CTGCCACCACCTTTCCTCCTGGGGCTGCCCTCCTCAGCTGTTAGTGCTCTAGCATCCTGTGCCACCACCCCCATCCCCATATGGATA


CCTTTCTCCCTGAGATACCCTGCTCTGGGCTTCCACAGCATCCCTCTTCCTACGTTTTTGTAAACGTAGGAAGCCTACCAGATTGGA


CCTACCTAATGGCTTTGAATTTTCAGGAAGGAGAAGGCGAAGAGCCTCGGCTACTCTTGAATGATGTAAAATAAGACTTATCTTCCT


TCCCCATGGTCCTTCATTATTTAAAAATAGCCATTATGTCATTCCTAAACATTCTGTTTTCCACCTTTAAAAGCTCCTAGTTCCTCC


ATGTGTTTACACTAATGATGTTTTTCTTGTAAGCATCTCAAAGAGTCTTCCAAACATATTATATCTTTGTGACAGATGAAGAAATTG


GAGTACAGAGATGTGGAGTAACTTTTGAGATGTTGAAGAGCATGTCAGGGTTCGGTTTTAGAGTGTTAGGTCTACATATACTGTTTC


CAGATTGTTCTTTGCCCTGGTCACGGTGCTCTGCCTAGGGTCCCATTTGGACACACCTCTATTAATGCAGCAACCAGAATGAAACAC


GTTGTTCACAGGCTTTTCTAACCATCCGAAGAGCAGCAGGCTCTTGAACTCTCCCTTCAGTCCCTAGGCTGTGCTGTGCCTGGTGGC


AGAAGCCTCTGCTACTGTCTGGAATTGACTTTGAGTAAGTTACTTTCACACATTAGTTCCTCAGTTGCTCATCTAAAAAAACCAGGA


AAATAATTTTCTGCAAAGTTGTTATCCAGTATTATGTGAGATCATGCATATCAACGTGCTTCATAAATGGTAAATCTCTAAATACAA


ATACTAGTTATTAACCCAGGCTAAACTGCACTTGCTTTCCCTGGCAGCCAACGAACACTTTGGCTTGGATTGACTTTTTAGTGAAAT


AAAACCTTCACTTTTTCAAGTGAACTCTATTAAACCATCCCCCTAAGCTATATGCTAATCAGAAGCCCTAACCCTCCAGTTAATTAT


TTGAATTTAGATTTAGTTCTGTTTATTTCTCCCATTTAAATGTCTTATTCTGGCCCATTGGATTTCAAACCTGCTACCAGCAATCCT


AGGCCTCCTTGAGGCGTATGTGGGTGGGTGGGTCTGTGCTGGTGGGGTGTGGACTGAGCAGTACCTCTCTTTCCTCCAGAAAAGCTT


GGTTATTAGTTTGATATTTTGGGATACTAAGAAAGATTTTGCTTGAAAAAAGGGGTCCCACCACTTAAGAAAGAAAAGAACCAGTAT


TCTAGCCTTTAGATGTCTTTGAATCTTGATGGCCAAAGTACATTTTTAAAAAAATTACTCCTCGTGTGGGTTTTTATCTCTTGGAAT


CTCTCCATGCATGGGAAGTCCCTCTCACTAACTAGGGGTCACTTCTGTAGGATTAGTTGATATTTCACCCCTTTATGCATGTAGTGT


GGCAGCCTGATTAGTAAGGAAATTTCAGTCTTCCCACTGGGAGATCTGGTTCAGTAGGTCCATCCAGGATGGGGTCCTGGAATTTCT


GTTAAGAAAAAAATCAAAACTTCCTGCAGGTCATTGTGATGCCCAGCTGAGTTTGAGAAGCTTTAGCTTGTTTTTCTTGGGAAGATG


TGGCCTCTCCTTCCCGTTGCTCCCTGGAGGGGATGTGTGGGAGAGCTGGGCGTGGGTGGTGTAGAGCGGTGACCATTTCACCAGCAC


ATGAAGCTAGTGTTCTTTGCTTACGAGAAAAAAAAGGTGGCCTATTTTATCCCTCATGGAATTTTTTATTAATCCAAAAACGCCAGT


TTATTTTTAAACCTGAAAGCCCTAAAAACAAAATGAGAAAAATCTCTTGAAAGAGAACCTCTGGTGCTGCAACTAGTTTGCTAGCAG


TTAGCATCATATAGGGCTAGAAGCTAGCCATTTATTCGATAGGCACAGTGAAGAGCTAGACTTCTGGTTCCTTTGCCCTGCTTGTCC


TGGACCACTCTGCGTGTGTCAGTGCAGTTGAGTAGCTCTAACTACAGACACTTAACAAGGGCAGACCACCTTCTCCTTCAAAAAAAA


TCAGCCTCCCCATCCACTGTTGCTGTTCCTTTCAGCCTCCCTTTTCTGGGGCTTTCTCGTTGGCCTCCAGCCCTGACTATGCTCAGT


TTGTAGGAGGGGAGTTGCTTTCTGCGTCAAGGTCTGCATGACAGGTTCATTGAATTCCCTCTGCTGTAATGCTGTGGAGGGGACATT


TCTTTTCCCATATCCAAACTTGCAGCACTGTCACAAAGACAGTTGACAATAAAGCAAATACAGAAGACCCAGACATGATATTTGCCA


GTGTTCTTTAGAAAGCTTCAATGTGGAATATCCGGGTTATGCCTAGTGTTTTCCTGTTATTTTCTTAACTTTCTTTTTTCCTTCACC


CCCTTTGAAAGTTAGATCTTTGATTACGGCTGGGTTCCTAAAGTAGAAATCTTCAAAAATAACATTTTGAATAAAACTCTGTATTAT


TTCTCTGAGCTGTTTTACTGGGTCTAACACCACTCCTTTTTTTTTTTTTTAAAAACAAACAAAACAGAAAGCCAACCAAACAAAACC


AAACCAGAATGGTATGCAAACCCAATGGTTAGCACTGTGATATTATCCATATGTACATAGAGGATTGTTAGTTATGAATCACAAGGT


ATAATTTTTAAGTAATATAATCACTAAGCCCAATTACAAAATGGTGTTTTTGTGGATGCCAAAACATCTACAAATGGCAAAACATTT


TGGCTCTCTTCATTGGAAGGGAAAAGTGATGTTCTATACCACTTCCAGCTACTATTTACTATTTTGATAAGTATTAGAAGGCATAGG


GCTCTTTTTACTTGTTGGAAAATTTTTCTAAATTACACTTGGCACTAAGGCTTGAATTTCTAAAAATCTGGAGGGAACAGCTGGTGC


TCTAATAAATATTCAGGCCAGCTATTTTAATGCATTGTACTCAATTAAGTAGTCCTAATAAAAGAGGAATACTTGACTTAAGCATTT


CTCAAAGCATAATGTTGTGCTTCCAACAAAAATTTCCTCCAACTGTTGATATTTCCCCCCAAGCAGCCTTAACATTTAATTCTGCCA


AGTAAGTAATCTAATCATGGATGATGCATTTAATGCCAAAAGTTAGTTCTCTTTTAAGGTATAGTTGTATCAATGTGGCCTAGCCCT


TTAACTGGAGACTCCATAGGTCACTGACCTTTTAGAAGAATTCTTCGTCTGGTTCAGAGTGAGAGAGTATTGAAAGATTCATCCTAA


CTTGGGCATTCTGGTACCCTTGTGGTGGGAGGGCAGAAAGTCTGCTGTTAAGGAGTTTAGACTTTGAGTGTGTCTGGATTTTTACCC


AGCTATGTTCCCAAGCTTGTGACCTTAGACGTTACTTGCCCACCTTGCAGTTAAGTCTCCCCTTCATCTGCAAAATGGCACGTTTAG


TAGTATTAATATTATTAATAGTAGTATTAAGATAACGTCTATCTCGGAATCCTGAGGATTTGAGGAGTTAATATGTGTAAACTGCTT


GGAATAGTCAATAGGTATTAGCAATTATTATACTGTTTTCCTCATAATTTATTTTGATTGTTTTCCCTTCTTTCAGAATCATTAAAA


TAATCTTACATTGTAACATATATTTTTTGTTCTCTCTAATATTCTGCCTACATAAGTGCATTCTCAAAATAACTTAAAAGGAAAAAA


AGATCTAACAAATGTTCACAGTGTTCTTTTCATTGTAATGAGTGGCACGCAGTTCTTATCGTGGATACCAGACCATGAATTCGCTTC


TATTGTTTGTTGTTAATTTTCCCTTTTTTCTTTACCCAGTTACATTCACTATTTTCTTTGCAAAATCAAAGTGTCTCCTATTAGTAT


TTTGTACTGGGAAGTTGAGTTTCTGATGGATAGCTGTGGTGGTGTTAGGCCTAACACCTGGGTGGGGTGGGGAGGATAGATACCCTT


TGTCAACATCTGTTAAATCTGGGCATTCTGGAACTATCTAGATGGCTGTAACTAAGTGTCTTTAGTTCTTTATGGTATCATAAATCC


TGCATATTTTGGTCATTTTTTTCCTCTATTTCAGACAAATTCTTGAGGTCATGAAGGTGAAACTTGAGTCAGTGATCCTGATAACTT


GGGTTTTCCCCTTATATGTCCTTCCAGCTGATGCAGAGCTAGGATTTTGGATTGAACTACCTGGATCATTGACTAATCATCTTGGTG


AATGAGAGACTCACTGGCTTCTCCTCTAGGGCATAATGGGATGCGATGAGAGCTTGTGCTTTTTTTTTTGCCACCTGTACTGTCCCC


TGACACAGGAGACATGGGCTGTCACATTTCCAAGTTGCCTCTTCCATATAACTGGGCTCAGCTCTGAGAGGAAGGCCAGGGCGTGCT


AAATTAGTAGGTGCCTGTCACTCATTCCCATGCAGAAGGCATGCTGAAAACCCCAGCCCTTCAAGGGGAAGCAGGGGATAAAGGGAT


AAGTCTAAGTAGAATTTTTACTGTAGTTTTTATTAGTAAAAAAGAATGATATATGTAGCACAACAGGAACAGAAGCGTATTTAAAGT


CATCTCTAGCTTACCAGAAACACCCCTAAAACTGCTGGTTTAGATTCATTAATCAACCTCATGGTCCTCAGATGGGTTGTGACTCCC


TGTTGCGTAAACACGAACCATGTTACTTCCTGGTCCTCCTGACCTCCACTAGCTGATTTCAGCGAGGATCAGGAGTTAGGTCGCCAG


CTGATCTAAAGCAGCGAGTCCCAAAGTTCAGCCATTTGTAAACCACCTGCATGGTTTTGGACCAACTCTTGTGTCACCCCATAGTTT


CTCAGATTTTAATATGCATACAAGTGGCATGGGATATGTTGTTCAAATGCGGATTCTGGTTCAGTAGGAGTGAGAGGGGACAAAGAT


CCAGTACCTTTAACAAATGCCCAGGTGATGCTGATGGCTCTGGCCCACTGATCTCACTTTGAATCTCAAAGATATAGTCCATCTGAA


ACAATCTTTTCTTTTAAATTGACTCTGATTTTAATCTTAAATACATATATTTAAAAAGGAATGTAAAAAGTATCACTATTCAAATGC


ATATAATGACAATAATATGACTTACTAACTTCTAGGTAGCTATTATTGGTGCCTGTTGGTAAGCCTGAGTCAGAGGCCTCTTTTCTT


TTGTTATAATGGAGGTTAACAAGTGTAGCAAGTGTTCGACATTCTGGCATCAAATGGAGACTTTCTCCTTAACTAGACCAGAGGATG


AAAAGATAGTTGAAAACCAGTGACTTTATATTGAAGGATATTTAATGCCACGTTCTAAAACTTCTCTTCTGGTACCCCAAGTCACCA


GGGAATCGCACTTTGGGGAACACTTGTGCTTAAGTAATTTGCAGCAAGGCATGCATTTATAAACTGAAATCTATTAGTGAGGTGGAT


GGATCCCTAGAGGTAAAATGCTTGGGGAATGTGTTTAAATGTTTGCATACTCCATGTTCTGTTTTCTGTTGAGAGTGTGGGAGAGAA


GAGGGGCATCCCCCATTTCTGAAAAGTTGCTAACCCTAGGCCCAGTGAGTAGTTACATCTTAGGTATGAGAAGGAAAATGCTTTGGG


AAATTGTATCTCAGGCCAGCAGGAAGTCAACTTTAAATGCTTAGGAACTGTATCTCAGTGGGCTTCCTCCTCTCCTCTTTCAAGTTA


CTATAGGTATTGCTTATGGTCAGCTTTGGAATGAGTCTATTTACATAATGCATTTTAAAAATAGGGTGCTTTTCATTGTTCAATGAC


GAGTTAGTGGGTGCAGCGCACCAGCATGTCACATGTATACATATGTAACCTGCACATTGTGCACATGTACCCTAAAACTTAAAGTAT


AATAATTTAAAAAAAAAAGGGTGCTTTTTTATTCCAAAAATACGGGAACATCAATATTGCTTTTTTAAAGGAAATTTACTACAATAA


TATTTTCTTTCGGTTCAACTGTATTAAAAGTGGAAACTCTTCGTCAGGTGCTCCGAGAACAGTGAACAAACACTTCAAATGAAAAAA


ATATTTTAGAGTTTCAGTTGTATTTCCCTATGAGGCCTTGAATTTAGCAAACCTTAGTTAATTAACTTTTTAAAGGAAAAATGTGCT


CTTACATTAGTGGCTTTTAAGCATTTCTTCCGACTTTACCGGCCTTTCCCCCTTAGGACAACATTTAAAATAAGTGTTTTCAACAAA


CAGAGCAAATACCTTGTGAATAAACATCAATTTCACACAACCAGAAAAAAAAAATAAATCAATAAATCTCCTTTAGGCATTTGAAAA


ACTCTATACTTTTTAAAAAGGGAGGAGTTGTAATTCAGTAACAGGAAAACTAAACCCCAAGAAACCAGGCTGTTAGTTTTAGATGTT


TTTCAGCATGACCTTATGGAGGCAGAAGACGGGCTGGGAACTTCCTGAGCACCTGTTTCGTTATTGGTGCCCTACTTATCCAAGGAT


GGGCAACAACTGCCCACAGGGCAACTCCTGTGAGAAAGCCTACTCTGTTTTTGTTTTTAATCTCATAACTGGAATCCTAGGGAAAAT


AGTGTTTTCTTTGGTACCAAGTTCTTTTGGCTTCATCTATTGGGTTTTGAAAGAATAAACTGAATGAAGAGCTGTCTAGATGATACA


ACTATATGTGGCATTTTCATATTTTTTCCTGACCCTGCAAGATTAATAATCCCTAATATTCTCACTATATGCTTTGAGAGTTTTGCT


GTCCAGTGAAGATTTGAAACAATTGCACAAAAATTTGAAAACGGTGTTTTACTTGTCATGTTTAAAGATACAGAGTCACTATTTTAG


AAGTGAAGGGATAGGGGTCTCAAAACAAATTGAAATATATTTTGTGAAATATATACATATGTATTCCACTTAAATATAAAATATATA


GTACCAATATATATCCTTGATGCTTATTAAATACTGATCTATATCCTTGGACTTTTTAAAAAAAGTACAGTCATGTATCGCTTAACA


ACAGGGGTATGTTCTGAGAAATGAGTCATGGGATTTCATCATTGTGCAAACATTGTAGAGTGTACAACACAAACATAGACGGTGTGT


AGCCTACTACACACCTAGGCTGTATGGCATAACCTGTTGCTCCTGGACCACAAACTTGTATAGCATGTTATGGTAATGAATACTGTA


GGCATTTATAACACGATGGTATTTGTGTATCTAAACATACACAAGGTACAGTAAAAATATAAAAGATAAAAAAGTGGTACACCAATG


TAGGGCACTTACCACGAATGGAGCTTGCAGGACTGGAAGTTGCTCTGGGTGAGTCAGTGAGTGAGTGGTGAGTGAAAGGGAAGGCCT


AGGACATTACTGTACACAAATGCAGACTACATTAACACTATACTTAGGCTACATTAAATTTACAAAAAATATCTGTCTTCAATAATT


AACCTCAGCTTACTGTCACATTTTATTTTATTAACCTTTTTTTAGCTTTTTTACTCTTTTGTAATAACACTTAGCTTAACAGATTGT


ACAGCTGTACAGAAATATTTTCTTTATATCCTTAGTCTATAAGCCTTTTTTTAAAAATTATTTTTTATCTTTAAAACTTTTTTGTTA


AAAATGAAGACAAAAACACACACATTAGCCTAGACCTATACAGGATCAAGATCATCAATACATCACTAGACAATAGGAATTTTTCAG


TTTCATTAGAATCTTATGGGACCACAGTTATTCCGTCATTGATTAAAATGTCGTTATGTAGTGTGGGACTGTAGATATGTGCTCTCT


TTGGAGAAAAAAAAAGAGAAACTACCTAAATGACCGTATCACCTCTAAATATTTTCATTCATAAGAGACTAAAATTTCTTTACTGTA


GTATACTATAAATATGCAAACTAAATGAAACTTGTTTTAAAGTTAAAAGCTGGAGATCCATTTTAGAAACTAACACATAAGCAGAAA


AAAAATTTTGTGGTTATTAGTTGGAGGCTAGAAAAGAAACTCTTTGAACTATGAAGTTACTAAGTCTTAGCTAGAGACCCCAACAAA


TGATTAATTATTGCTAAGAATCTTTTAAAATCCAGTTTTAAAGTTTAAGTGTTGTTTCTGTGGTTTTTTTCCCTCACCTGCCCCCTT


CTTTCTGTGATTCTAATTCCAAAATTGAGAAGACAGAGCTTTTTACTTTTAGGGAAGCTAAACCTCTTTCTTGCTCTAAGAAGGTTG


ACCTGCTGATGAAAGAACAGAAGGTTGGAATTCTTTTGAGCAGGAATAGCTGTGCAAATGCTTATTTCATTGTTCTTTGGCCAATCT


TTTTAGCACTCAAGTATTAGAACTATGCTTTAATTGGTCTTTTGCAGCCCTGATTGTATAATCTTAGGATTTATATGTTGAAAGAGA


CCTTACAAATAATTTGGGTCCTAGTTTTTACTACTCACTGTTCAACACTTTGCCTACCCTTTTCATAGTGGAATCCTTTGTTTTCCT


AACCAAAATTTTAAGCAAAGACCCCAGTTTATAAAACAAAGAACAGAGCTTCTCTTCTGGGAGCCCAGCATCTCAGGTGCCTCAGCT


GTGTTCTTGGTATCACTGTGTAGGAACAGTGTGCAGAGGGGACAGTGGGAGTCCTGGTGGATTTTACCCATGGGTGGAGTTTGAGCT


CAGACTGGTGGAGAAGGCATCTGCTTACCGTTTATATGTTGAATTAGGATGAAGTCGGCACTTGGCCTGTGTTCTTTGTAGGATGTG


TGCACGCTGAATTGTCCAAGTTCCCAAGTCCCAGCACTTTGACTGTATTTGGTTCCACTAAATGGTTTTGGCGCAGTCGTTTTGATT


AACATCAACCTTGCTTATGTTAAGTAACTATTCAGGTTATTTATTATGCATTACTCTCATGCTTTGGAATGAGCAGACTCAAAAACT


TCTGCTTCATATGGATTCCATATGTGGCCTTTAAGTTAGCAGAAACACAAAGGTTTCCAATTAATTTGCACATAAAATTGTATATTG


AGTAAGTTAAGCTTGATGGCATAGGCATTATTTGAAATTCTTTGTCATCTTTAATATTTTTATATTTCATTTAAACAAGTTATTAGG


TGTTTGAAGGTTCTGTGGTGACGAACATAACCTACACATTCACATATGTCCTGTTTGGTTTTTTTGTTACAGAATGCAGGTATCCAT


GGAATTTATTTTATTGTTTTATACTGATGAGCTCCAGATAGTAGGAGATTATATAAAAAGAGGGGATATTTACTTTTTTATTTCTGT


GATTTAACTTTTTCTCCCCTCCTCTTCCCAATGCTAGGCAGAGAATATTACAACATGTAAGACAGTGGTTAAGGGTGAGACTGCCTG


GATTCAAACATGGGCCTTGATATGTCCAAGCTGTGTGACCATGGATGGTTACTTCATCACTTTGAACTACTCCTTTTGGGCAAAAAG


TGGGTAATATTAGTGGCGACCTCTAGGATCATTGTGAAGATTCCATGAGATGATGTACATCCAACCCTGAGCACTCAGTGAATGCTG


ACGTGATAATTGAGGGACCAGTAGGTGACCCACTCAGGGGAGTTGCGGGCTTTTGGTTCACTGTCACCTGGGAAAAGGTGTTGTCAG


TGTCCGGACCCTCAACTTTCCTTGTTAGAAAAGTGTACCCTGTATAATAGAACTTGTCACTAATGCCAGGCTTTGTTTCCTTTGTCC


CCCACCCATTGGAGGAGAGTGTATCTCCATGCTTTCCTTTGGCAACTGGATCTGAGGGTTTTCTCATCAGAGCAGCTGCCATGTTCC


TCTCCTCCTCGGCTGTAATTTCCTCTCCTGTGTAGCCATAGCTGTCCACCACGTCCATTCCTCACATGGCCTGGCCAGTCCTTCCTT


TCTGGATAACAACGCCAACATTTCTTATGTCTTACCTCAGGGATCATTTTCAGGCCACAGACCTACCTGTTTTGTTTTGTTTTTTTA


AAATGGTAGTATCTACAGAACATTACAGTTTCCGTAAAATCATGTATATAAATATGCCTAGAAAACTACCTGAAATATAGCAGCTAT


CCCATAATTACTAATTGAAATACGTTAGTTGAATCTGAAATAAATTTCTTAGCCTAGGAACAAAGTTAGCATCCATCTGGGTCTCTG


CAAAAATTTGTAATGTGTAAAAATAGGCATGTTTAGGAAGTTGCTTAATTTATTAATATATACTTCATTTTTATGGCAGTTACAGAT


TCTCTAATTGAATTTATATTTGCATGATTACAGTTTTTTTTTTGTTGCAAACGATTTTTATGGGCTGCTGAAGTTTAAGGACTCTGG


CATTTTAAATTGTTCTTCACTGTCTGAGAAGTAAAAATATGTCTTAAAAAATCATTGATGTTATAGTAAAGGAAAGCTCCCTCCCTT


CCCTAAGTTAGTGCCTTTCAGAATGTGAGCATTTGTCAAGTGGAATTCTGTCTGATCCTTTTTCATTTTCTGAGCTATTATAAGTGC


TTTCTTTTCCTTTAACTGTCATAAATGGTTTTTCTTCCCTTAACTAAGTAAAGATTTCTGGAACAATGTTTTGACCAGATTGAAACC


AGCTTCTGTCCTATCTACTAGTCATTCATTTCTTGATTTCTCGTGCATTTCTAAACATAGATAAGTTTCTAATGGTGAAGAAAGTGA


AACAGAAAGGAAGGAAAGAAGCAAAAGCTGGGTTGGGTCACCATATTGAGCGAAGGATATGCTTGTGGGGAATCCTACACTGTGATA


TTGGAGTAAACAGTTACATTATGGGGTGAGACCAGGTGAGATGGCTTATGCCTGTGATCCCAGCACTTTGAGAAGCTGAGGTGGGAG


GATTGCTTTAGGCCAGGAGTTCAAGACCAGGCTGGGCAACAAAAATGAGACCCTCTCTGTACCCCCCCCCCCCCCCCCCTTAGCCAG


TCACAGTGGGGTGTGCCTGTTTTCTCAGCTACTCTGGATGCTGAGGCAGGAGGATTACTTGAGCCCAGAAGTTCAAGGCTGCAGTAA


GTTATGATTTTGCCACTGCACTCTGGCCTGGGCGACAGAGCAAAACCTTGTCTCAGATTAGATTAGATTAGATTAGAATAGATAGAT


AACATAGATAAGATCAGTGTTTCAAAATCCTTTTCCAGTGAGAGGCATGTACTGCTGCTTTTGTAACCCATGACATTGAGAGTGTAG


CAGGGGGTTCATGTGGAGGAGTTGCTGAGACCAAGAACCCCGTAAGGATAGTCATCTAAGTTTGGGAATACACACAAATTGTTGGGA


GACACTTCTCCATGGGTCTCTTGTGCTCCTGCATGTCTTACTGAGTATACCAAGAACGTTCTTTACCTGGGCCATTTCTTCGTGTTG


TGTTTGCAATGAGCAGCCTTGAGGGATGAAGTAGTGTCTCTTTCTGGGACAAAGACTGACCTACTCTCACTTACTGCTTACTATAAA


GCAGCAGGTTTCCCAAGCATAGGTTCCTCAGCTGGATGCACGCTCACTGCATGTGCAGCTGCCATCTGGGCCCCTCAACGCTATTTC


CATTGGACTGATGTAAACATGATGCTGGTGTTGTCTGAATCATGCTGTGAATAATAAAGTCCTTTGTCCTTGACCCGGGAATCTCAT


GTCTTCTGCCAGCTTCTATGAAACAGTAACAGGCTAACTTATTACCTTGCGAGTAGGGTAAAATCAAACAAGACCAGATACAGGTGG


AGCTTCCAGATGAGCTGAACATGTGGAGGTTCCTGTAGGGTGGTGCTCTAGAAAGGGCATGGAAGCGCCATGTCCCTTGCCCCATAC


CTTTACCTGTGAATCTCTTCATCTGTATCCATTGTAATTTTTTAAAATAATAAACTAGTAAATGTAAAATAACCAAAACAAAGAAAC


CAAATGCCGGTGTATTACATATAAGTTGATACCTAGCCAGTTAAATGCGTTCAGATGTGTCTTGTTTAGGAGGTAATCACCCGGGCC


TCCCCCACAAAGTATGGTTCAAAGGGTCATGGTGGGTGGCTCCTCAGAGCATCTCAGCTCCCTTAGACCTGATGAAGGCTTCACAGG


CATTTCATATCTGTGCCTCTGGCCAGTATATCTCCAGGGAACTGAGTGCCAAGGGAGACCAAGGCATCTTTACTGACATTGTTGTAC


CTTAAGTGAGGCAACATGTAAAACTGTGACACATGGGAGTGCTTGATTTTTGAGCGTGCGGAGCAACAGGGTCCAGTGTTATGGTGG


CAGGGGCAGGAGAACTCATGGCATCAGGAGCGTAGACAGCCCCACTGGGCACGAATTATAACCCAGGCAGAGGCAAGGCGCAAGGGT


GGTCAGACATCTGGCCCTGAAATAAGAAGAGACAGGTGGGAAAGTCCAGGCCAAGACCGTGGAGCAGAGTTAAGAAGGAGCAGGAAG


AGCCGATCTCAGAAACAGGCTGGCTCTGTTGAAATTGGACTGAGGCAGATAATTTCTTTCTTTCTTTTTCTTTTCACCTTTCAGCAC


TGTTGGACATGAAGGAAAGATAATTTCTAAGTTTACTTTTTGATATTTATAGATAAAATGCTTTCAAGCAGTTAACCAGCCTATTGG


AGAGTGACACTTAGATCATCTTCAAGTTGGTTTGGGCGATTTAGAGAAACATTTATAATTAAGTTATGCAGTTAATGAAAGCCAAGT


GGGGACATTTGTTCAGAACAATTGTTTTTGTACCTTTTCTTTGTGATAGAGCTGTAAAAGTGTATTTACTTGTAAACTGCAACAAGT


TTTTGCTCCTTCCCCCATCAAAAGAATAATATATCTATATAATAATTAGGCCTGAAATTAAGATTCTAGATTTAAAGAGGACTCCCA


GGGCTCAAATATAGGAGATAAGATGTTGAAACACCACTCCTGTTGTTTGCAAAATGAATATTAATGACATTTAGTCAAAACCAAATT


CTAAATATTTAATAATATGTGAAAATTATTAACTGCCTGTGGTCATCAGTTGAGACCCATAGTTACTGCTGGAATCCAGGGATACAG


GGATTAAAAAAATAATGGATCAGAAAGTAGATGTTAATGGGGAAGTATCTGTGGGAGAGTGACCTCTTATCCCTGAGGGCCGCCATG


TACAGCTACACAGGAGGCGAACTGCACAATTCCCTGGAATGTGCGTGATGCTCCCTGGAGTTGTGCAGTGTGGCAGTGCTGTGTGCA


TCAAGGGCAGGAGCAACGGCAGTCCTTCAAAGGCTTAAGTAAGTGGCATAGAAAGTGGACAGTCCTTTTAAGTTGCATGGCTTCAGA


CACTTCTGTTAGTGTGATAACTACTGCCTGTGCCTCTCACTCTTTGAAGAGGAACTTGCTGGTGATGGGGCTTCTCATGGGGAAGCT


GGGAAGCTCCCTACCAAGGGGGAGGGTTCCTAAGCCTGACAAGGACTGCTCATCAGGTGCTTTGGTATCCTGTAGACTGGGCTAAGA


AACCTCACACCAGGGTCCACTCTCCAGCTGGTCTCCACTGGGCCTAGGGAGACCAAAAGACCTGCAGTTGCTGAACCTCTCTTATTG


TACCTGTGAAGCCAAGTAAACCATTTGTTCACTTATGTTAAAGAATAAGCTTGATCATTCATGTTCAAAATAGTTAACTCTTTTTTG


TGAATTAATAGTCTGGCTATAATTACATTTGACATTTCAGTCCAGTATATTTGTCATCCAGATGAAGAAGCTGCCAGCCGCATTTTT


TTCCAGCAGTTTTACTTGACTTTCTTTTATTTTATGTACAAGGTGTTATTTAAGTGCACAGATTAATAGAGATAATTTTTATAATGT


AAAATTATTTTTATTGCATACCTCTATGAGTAATTTCTCACTTGCATTGTTATAATACCTCCCATCCTTCCCTAAAGCGCCACTCTC


CCCACTCTACTGCAGGAGATTTCTCTAGCAGCAATTCTGATTATGTCATACTCCCCTGCTTTAAATAGCTAAATATTCTTAATTTGG


AAAAGATTAAAGCTAGGCACCATTATAGGAACCTTGCCTACTTGTCACCTCTCATATTTTCTCATCCATATTCTGTTCCACAGTCTT


ACCTGCATGGAGCAAAGGTGTAGGGCATATTTGATGTCCATTATAAAATATTCAGGCTCCCTCAGTTCAAGGGTCCTCCACTGTAAA


GCAGTCCACTATGTATGCAGGTGTCAGTCCTTTTTCCACCACCTTGTGGGAATTGGGACTTGCAGAACTGCCACATTATGCCCTTAT


TTACATTTCTTGACTCTGTAGCTTTGCGCTTACCTCTGCTTTAAATGATATTTCTGCCATTTCTGTCTACCTTCCATCAAAGGTATG


GTGTCTACCTTTACAATAAGATTGTAAAGAATAAAGAGGTAATGAGTACAAAGCACTTAGCTCAGGGCTTGATTAGCTGCTGCTGCT


ATTATTGTTACTCTTGCAAAATTGGTTCCAGAATTATACCCTTTGGGTGCTCTTTCCTAAACTTCTTCTATCCCTACCCTATTATTT


AGGGAGACCCTATTTAGCAGTTCAGTCTTTATATATTCCTTATAGCTCTTTGTTGGCAATATTTTTAAATCATAAAGAATACCTAAA


TCTATAATGATACTAAAAAGAGTATTTGTCTAATTTTCTTCTGGCCAGGTGGATGGCATCTATGAAGAGGGGGCTGTGGAACGCTCT


CAGCCAAAGAGTGCTAGTCTGGCATGTTGTGCTTTTTCAGTTTGAATGGCTCTGGGCAATCTGTTTTGCTGTAGTCTCTTTTTTTCC


CCCGTTCAGCACCTTATTTTCCACCTGATGGTCTTTGATTCACAGCAAATTGTTTGTCTTCTAAAGGATAAATCGAAGGTGGGTTTA


AATGGTTCAAATACAAGCTGGCTATTAAACTGTGAGTTTTACAAGCTGTCATGTCATATGGCCTGAGTTCTATCTAGCTAGATCCAC


CATTGGAACTATTCTAAGCCATGGTGAAAAGATAAAAGACATCAGCCAATAAATCCCTTCCTCATGTAGGGGATTCATTGTTGGGAT


AGTACCTCCACAGGGTGTACTATCAGGCCCAGGCTTGTCACCATGACCTCTTTGGTGCTAAGTCAGTTAGAGGACCCATTTCTCACT


GGTCTTTGAGTTCCCCATGGGATAGGACCTTAAGGGGGTTTTATCCCAAGCTTTGCCAGGGCCTGGCTTCTGGAAGGCATTCCATAA


ATTGTTTTGAATGCATGAATGACTAAATAAGAAAATGTGAGAGTGCTTCGTTAACTGTAAAATTAGCTAAATGTCAACTAATATTTT


TTCCCTTCTGTGATGTGGAAAGATATGCAGGTGCAGGAGCAGGCAGCTGATGGTGGAGACTGGGGCGAATGGAAAGTGCCTGTTATA


AATGGCAGCCTCCTTACCTGTGCTTCTGTCCAGCTCTCTTGCCTCTCACCCTGAAAGGCTGTGGTCTGTCAAATCACTCACAGGTCT


GTCTGTGGAGAAGTCCTAAGTAGTATAGGGTCCCCACTTCTGTGATCCATTTCAGTTCCAACCCAAAGGACTTTCCAAAGAATGGAC


ATCTTTTGTCTCTTCTCCCACTCTGTCCAGTTGGGTTTATAATCCCTTTCATTATCTTCTCCTCATTCTCCCCACTCTGTTCTGGTC


TTCATCTGTAGAAATTTATCTGTCACCATTTTGGGTGCTCAGGATGCTATCGTTTCTCAGATCCTTCCTTCGTGTTTCATGGATACC


TCCTGGAACCCTTTTTTCAGTGAGCTGGGAATATGTCTTTCAAGAAAAGGAGGTGGTATATATTATAAAAAATTTAATTTGGGACAA


AGCATCTGACAAAGCGTTTTTCCCTCCTTATGTGTGGACTTACAGCAAGTGTTTTATAATAGCATGCAAAGTAAACCACATTTGATG


GGTTTTATTGAAAATAATACATTTACCCCAAAAGGGGAAAAAGTACATTTTTGTGCATGTCAATTGACAGTATTTGAAATGGAAATT


TTTCTAGAAAATTTGGGAGGTAACAGTCTCAGGAAAGGAAACTTTATATGCTATAATCCAGACATTGGTCACAGAGAGATTTCCTTT


GGTGGCTTAGGTAGGGCAAGGCAAAAGGCCCCTTGTACCCATCTGCTGTAGAGATAGCATATGGAAGAGCCCTGCCACTCCCTGCCA


GTCAAGCCCTTGTGATAAATCTTGATACTCCCATGTATATTTGCCTGCTTGTGCTGCCAAGGCCACTGAAAAAGGTCAGTGCTTTGT


GAAATGGAGAGTATGATATAAACATAGAAGTTGTTAGTAATTTTTATTGTGATTGATCACTTTTTTTTTCTTTTCTTTCCTTTTTTT


TTTGAGACAGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAGTGGTGCCATCTCCACTCACCGCAACCTCTGCCTCCCGGGTTCAA


GCGATTCTCCTGCCTCATCTTCCTGAGTAGCTGGGATTACAGGCGTGTGCCACCACGCCTGGCTAATTTTGTATTTTTAGTAGAGAC


GAGGTTTCTCCATGTTGGTCAGGCTGGTCTTGAACTCCCGACCTCAGGTGATCCTCCCGTCTCGGCCTCCCAAACTGCTGGTATTAC


AGGCGTCAGCCATCGTGCCCGGCCGTGATTGATCACTTTTAAGTACATGAGAATTCTTGGCATGACATACAAAAGAGGATGGGCAGA


GTTCCTTTTCCTGTCTGTGATATATTTCATGACGATCCAGTCTTTGCGGGCAGTGGTTCAGGGTAGTGCAGCCATTGTAACCTAAAC


CATTCCTGTGTGTTTATTTATCAGATTTTCTCAAAGGGTGAGTGCTGATCATTTTAAATTCTGTTTAAAAATAAAATTGTTCATCGA


AGTGATGAAATAAATAGGGGTCAGATATGATTTTAGAGATTTCGAATCCTGAAGAGGGTTTGAGATTTGAATACCATCTCTGTACAC


TCAAGGCAAACTTCCTGTATCACTCAGGACTCATAACTTCATCTGCAATTTTATTATTGGGTGACATAACTGAACAGGTCGCTGCAA


ACACTGAGAATTATTGAGTTGTTTAGGTGAGTCTCTCTTGTTTAAACTGTTGAAAGGTTCATTGATTTGTGGGTGAGGGAAAACTGT


TGTAGCGTAGTTTTAGTGTTTGCATTTCATTTTAACATTACCTTGCAAGGGATTTTTCATGCTGTACTAAGGAGATTACAAGGCCAC


CCTAAGGCATTTTAGGGTTATATAAGGAACTGGCTTTGCTGTTTTATGTACTGGCCCTTTTATTTTCTGGCTAAGCCAGAATCTTGG


TAACCCTCTCACCTATCACCTTTGGGTATTACCTTTTCAGCTCTCCCTTTGCCCTCATGAGTCCAACCAGTGCCCTGGTCTGAGCCT


CCATCCTCCCAACTGCCCTGGCTTCCTGCTGTCTGCCTTCCGTGTTCCTGCCTACGGTTCATGCTTTGCCCTGGACCTCAGTGGTCC


TTCATGTCTGTCTGATCACGACACCTCATGCTATGAGTGACCTCCACAGCTTCTGCTGCTTTTGGTGCAGCATCAAATCCTCCCGGT


CTGTGCTTTCTCCTTCAGGGCCCACCTGCAGCCTTATTCCCTTCTCCTCTTCCTTCTCTTCCACTCCAGTCCTCCTCCCCATCCCCA


GTCAAGTTAACCCTTGGAATATTCTGTCATACCACCCAGGACTTTTCCTTCAGAGCATACATCATAATTAGGTGAGGTCATTATTGC


ATATTTGGGTGATTATTTGATTGTCTGTATCTTGCGCTAGGCAGTCAACTTCCAGAGGGAAGTGGCTGTCCTTTTAATGCAGCATTG


ATGGTAGCACCCACACTCAGGGCAGGGTTTTCGAAGTGCTCCATAGGTCCTGGTTTTCCGTGACAGTGCTGGTATACCCCTGAAGTC


CCCATGTAATTTATTAATAGTGTCCCCTTTCACTTTCAAAGTTACTCTCATTTTGAATGACAGCATATATGATGATCCCTTCTAAAG


CCCAGTGATATGTAGTCATTCAGGTAAAAGGTTTTATTGTCAGGCTCCCAGAGTGGGAGAGCCTGGTTCCAGGGTCGGGGGGTCAGA


GGGGAGCTGTTGCTGAATTTTGATTCTGGCTGAAGATAATTTATCTTCTTGAAACTCTGGCAGCATATACAGATGTGCCTGTTGTTA


ACATTTTAAGAGGTAAGAACACTCTCTGTGCACCTGGGATTTTGGAATATGATAGTGGGAGGCACCAAGACTGTTACAGAAATGGAA


AATGAACACAGGGTGGCAGAGGGTAGGTACTTCTGCCAGTCAGAGGCAGACAGACTTTCAACTGGAAGGGGTCAAGGACACTATTGC


ATTGTGTTTGGCCAAACAAACAAAATGCATTCTAGGGGAGAGCTGGTTTTAGTCGTGTGTTTAGCGGGGGCTCAGTGAGAGGCACAC


AGATGATCTGTGCATCCATTTCTCTACTGATGTAAAGACTCAAAGAAGGTAGTGTGCACGGTGCCAGGGGAATCTTGTTGAATTACT


AACAGTGAAAAACTAAAAAGTGGCCTAAGATCTTGGTTTCTAAGGCCTATTATGGCCGAGTCCCCAGAGACAAAGTTTCCTCCTGTC


TGACTTGGAGCAGATGCTCGTCTGCCTCAGGAAAGGCTCTGAAGAATCCAGGAGAACATGCTTTGCAAGGCACTTTCAAATTGCTGG


GTCCCTTCAGGGGAAAAGGGGTTTTTATGACACCACTAGTCTGAAGATAATTTTTATCAGATCCTATAGCCTGAGGTCTTAAAACAG


AACAACACTAAAGAGCCCCTCTCAGGCCTGGCTTCCTAGCAGCAGTTGGATGGGACCTTGAAGTGGTGGCTCCCTTCATGTTGGCCC


TGCAGGGTCAGGCATCTAAGACTCGTGGAGGCCCAGGCAGTCTGGAGGGATACCAGATGACATAGCAAATGCCAAAAAAAAAAGATC


CAGTGCTATGTTTGCCTGTGTGTGGGTGTGTTTGTTTCACAGGTACAGGTGCACCCACCCGGAGTCAGGGATGGAACATGTGCAGTG


AAGGCTATATGCTTCCCAGATATTGGGGTGAACTTGATGAGAGTCTGGTGGTGGACTCAGGGACCTGGAATTGTCTTCCTCACTTTC


TTGCCACTTCTCAGTGTGAATGTTGTCTGTAGGGGGTGCTCTCCTTGCTTGCCGTGGGTCTCAGAGCTACCAGAGCATTAGAATGTA


GGAGATGCGCAGGCCTTGTGGACGTTTTGCCAGTCGAGCGATTCAGCAAAGTAATTGCAAGGTTTCTCTAATTGTTAAATATCTACA


ACAGGCTGAATTTGGATTGGCTGAAAAGAAAGGTGAAATGAGGTCATCAGAATTACATCATTTTTTTCAAGTTCTGGCATCTTGTGT


TCTTTGCCAAGCAGAAATATTCCAGTAGAACTGTGATAATGCCTTTCATCTATCTGCTGAGCCTTCCAGATGGCAGTTTCTCAGCCA


GTGAGCAAAAGAAAGGGTGTTGAGATTTATGAGTAAGTTGATTCCCTTCGTTTGTACTTCCCAGTGAACTCTCATTCGCTATTTGTG


CTAAGCACCAGTGGCAAGTTATCCTCACATCTTTAGCTCTGCAGGGCCCTTAAGCCAGTAGGCCTTACTTCAAGGGGAGGAGGGCTT


CAAATTCAGAGTAATAAATAGCTGTCTAAATAGAGCCCTTCACATACTTTCTCAGAGAACTTTTTGTGATCTAAGTGGACTTAAGTT


TCTTGAGGACAGGGGCACTCCTTTCTCCTGGGTAGCACCAATGCACAGGAAGCTTGGCGTTGGATTCCGTGGGCCCCTCCCTTTCTA


GTTATGTGCACAGTCTCCCGGGTTGAGAGAATCCCTCCCTTTGCTAAGTCATCTTCATTCAATCCAGGGATGTTTAGGGAATATGCG


TGCCTCGGATGACAATACAAGATGGATTAAGGTGATTCTTGTGCTTTGAGAGCTCTCAGTCCAATGGAGGAAAAACATATAAATAAA


TACACACATAAACGAGAAGTGGTGTATAAGTCTAAAGATCAGGTAATGAGGGAATGTTTTAGAGGAGGTGGTGCTGCTGTATGTATT


GGAGGCGGGTAGGGATTTGCTGAGCAGAACATGTGCCATGTTGTTTTCTCCATCAGGCCTCATGGCTGGAACAGCTGCAGTGCTTTT


CGTTTGGTGCCTCCTCTGCTTTGCCTTTGTCCTGTTCTTGTTCACTTTGAGCACCCTTGCAGCCTACCCTGGGCATAACCCTCCAGG


AACTCTGATGCTGTTTAGTAGATACTCAGAGGTTACCACTTAATCCTTGTTGGTTAGTTTTGTTCCCCAACTCGAGCGTGAATTCAG


GACAGGGCCCATCTCTGACCACACCAAATGCAGTCAGTGCATATGTTAAGATTTAGGGAAAGCGTTTGGGTTGGTTAGTCGAGTATT


TTCATAGATTATTATTACCTGGTTATGTAAGTATGACAAGACAGTTTAACAATGACACAAATATAAGCAGAGGATCTGATTAAAAAT


ACTTTTTTTTGAAAGGGAAGCATAAGTTTGTGGTCAGCAGCAAATAACCCATTTGATCTTCATTCATTTATTCTTCCATTTATTCAC


TCACTAACAGTCTGTACCTTTGTGAATAGCAACAGTCTTTTTCTTCATTGGTGTTTTTTGAATGCTGGGTTTTTACTGCCCTGGGGA


TTTTCTTTAAACCTGATAGTTGTTTTGATAAATCATCTGGATACCAGCTTTGAGCTAATTCTTTTCTATTAAGTACCTCTTAGAGTG


GCTGACCATAAACCATTTGAGAAATCACTACATTTTATTAATGACTTTTGAGATTTAGCAGCAACTTAAATTAATAATACTGGAGTG


TGCTTTGGATAAAAGACCAGGAGACTGCTTCATTCTGCAAACCAGAGCAGAGATGAGAATGTTTGCATTAGGAGAACGTAATTTATC


AGCATTTTAGGCTAGTGTGTCGATTGATACAAGGTTGGGCAATAGTGGTAGGCAGTGTTATAAGTGCTGTTTGTATGTATCAGCTCA


TTTAATCCTCCCAGTAACCCTTTAAGATGTCTGCACTATTATTTTTCACATTATTCTGATGAGGACATCGAGGCACAGAGGGGTTGT


GTGACTTGCCTGCAATCTTGGTTGTGTGCTCAGAAATAGTCTTTTTGAGACTGAAGATATTCTGGTTATGTGTAATACACAGTACAA


CTCAAAGACTGTGAAATAGTTCATAGACAAATTATCCATTCTTTGCCACTTTAGAGTAATTATGCTTATTGTTTCTGTTTCAGGATA


ATATGTGTGTGTTTATAAGCATTTTTTCCTTTTTATTTAATTGCAGTAACATATACATAAATAACTATGATGGCTAGTTTTGAACTC


ATTTAAAAACAAGTAAATTTATGCTTTGATAAGCTAAGGTACATTCAAAGCATTCCCATTTCCAAAGCAAAGTGTTTTCAGTTAAAG


ATTATAGATGTTGCCTTTTGCCAGGGATGCTTGTGAGAATGTCATTTAGAGAAATCTTAAAGTAATTTATCCATAATATTAACTTAG


CATGCCTTCTCTCTGCAATGTACAATGTATCATAGGACAATGTATGATACAGCTCAGTTTTGATATATCAGCAAGTTGAGTAGTAAT


TTTTGTTTGTTTGTTTTAGTTGTTTTAAAAGCTGGTGTTGCAGATTCCTATGCTTAGAAGGACCAGGCAGAAAATAAGCCATTAAGG


GTGCTGGGAATGCAATAGGGAGTGATGGGGAGTGTGGTAAAGGGGTCAGCAATGCTTCTGCCATGCCTATCAGGGAGCTGGTTTCCA


TTAGCTGTTGGTTGACCCAGGAATCTGTACCTGTGTTGCCAGATCTAACCATTTTCCAGGAGAGGCTGGAACTTCATATTTAAAAAA


TGAGAATTTGTCAACTTTAATAATTTGGAAGAAAATTCAAATTAAACCAATACCAGGCAGTGTGGTGTACCCCACATTACAGAGGAA


AGTAGGGGACTTGGGAGGTACATGAGTCAATCTATAGATGCTCCTGTTGTCATGTTAAACTTGTGCTTGCTTTCAGTTGCTCTTAAC


ATTTTGGGTCCACTGTATCTAGACATGTCCTTCAAAAGTTGCATGTAAGTTAATTTTTTTTTCTGTATTTAAAAAATGGCCCCACAA


ACACTAGTCTAGATGTTGAAAAAAACCCTTATACCTTATTATGGAGACTTCTGATGAGTCCTTTTGTACAGTGAACAATCACTTGCT


GTATTTACGTTTGTACTTTTGTGTTTAAAATGGGGAATGGTGTTAGATATTGCATACTGCTTGAGTTAAGGAGGTCGTTAACCAGGA


ATGCTTTGGATTACTCAGATTATTATTGCACTGGTGTTTGTTGTAATGGAATTTGACCTGTCAGGGGAGCTGTAGATGTTTGGATGA


GTGTTCAGTCCTTAATACTGTTATCTAAATTCTAGGCATGTTGCCTGTAACTTCCAGTTTCAAAAAATCTATGTCAATCTGTTCTTT


TATAACCTAGTGCTGTTGTTTTTTTCCCTCTTGTTTTATATTTAATCATTCTCTTTGGCTCACAACAGCAGTCCAGTCCAAAGATTT


ACTTTTTCTATTTTCAACCCCATCATTATTTTTGTGTAAAAAGTATGTTTTGAGTTACAGCAATTCATGGAGATCAAGCTTCTACTC


TGTAGGGAGAAGAGAGATGTCATTTACTACAGAGTTTATACACACAAATGTTCTGCTGCATGCTGTGTTCCCACTGAAATCCAGGGG


GTTTATTTGCATTTATACTTAAAGAAGAATGACCGTATTTGGCTGACTCTAAGCCAAGATGATACAGGCCCAAAGTTTTTCATGGAG


GAATGGGGGAGTAAGGGAAATAGGAACATTTGGAAGAAATAGTTGTTGTTTTTCCCTGTTTTATTCAGTGGCCATTTTATTCACAGA


TCATTTGATGCATTGCATTTACTCGTGTTATTCTGGTTCCTTTTGTGTTTTTTTTTTCCTTTTGAAACAACTTCACACTTACAGGAA


AATGGCAAAAATACTAAAATAAGAACTCCTATAAACCTTCACTGATAAAATCCCTTCAGTTTTCTCCAGTTATCCCAGTAACGTCCT


TTATAGCAAAAGGATCCGGTTCAGGATCACTCATACCCAGCTGTCATATCTTTCCAGTCTCCTTCATTCTAGAAGCATTCTTCATTC


TTCCTTCATCTTTCATGACACTGACACTTTTAATTACAGGCCAGCTGATGTGTAGAATGTCCTTCCTTTTCTTAGGAGATGTTTTCT


GTCCTTCCTTGAAAACCCCACTAGTGTTACCTGCCACGAGGAGAGCTAGGCGCTCTGCCCCCTACCCCAAGCTGGTTGCTCTCTCTT


ACAATGCTTCATTAATCAAGTACCCTTTTTTGGAGCATTGATGATATTCATTCATCCTTTTAGCCAGTAAATATTTTTTGATGTCTA


TTACGTGCCAAATGGGATACATTTAAGAACAAAGCAGACCAAAAAAAAAAAAAAAAAAAAAACCTGCTCTCATGAAGCTTACATTTT


AGTGGAGGGTAACAGATAACCAACAAGAAAAAATAAGTAAAACAGCAAGTACATTAGATCATTAGATAGTGATAAACGCTAAAGAGG


ATCGAATCAGGCAGGAAAAGGGATGGGCAGGTTCTTGATAAAGTGGCCAGGGAAGGCCTCCCACACTAGTGATTGTGGAGCAGGAAC


CCCAAGGAAGGGAAGGAACAGGCTGTGGGGCTAGCTGCAGGAAAGCGGTCCCGGCAGAGGGAGCCTGTAGGGGTGAAGGTTCTGCTG


CACCAGGTGGGCCAGGGGTGAGGAGGAGGCGGTCTGGTGGCTGGAGCCAAGCAGGAGGGGAGAGGAGAGTGGTAGGAAATGAGTCAG


AAAGGCAGAGCAGGGAGATTATTCTAGGCTTGTTGCCACTGAGGGAGATGAGAAACTCTGGGGGAATTTTGAGCAGAGAAGTTACAT


GATCTGACTTATGCCTTAAAAATCCTTTTGTTGTTTACGGAATAAGCAGGTATGTAGGGATGGGGTCAAGGTTAGAAGCAGAGAGAT


CAATTTAAGATCAATTATGGGAGGTTATGATAAGCCCTTTGTGTATCTGTTTGTCCTATTAGCACATAAAGGGGACTCAGTGGTCTT


CAACCTTTAGAATACATAAGATGTACCTGGGCTGTTCGTGAGTGATGCAGATTTCTTCACTGGGAAACCAGCATGTACCTGGGCTGT


TCGTGAGTGATGCAGATTTCTTCACTGGGAAACCAGCATTCATTAGATCTCACCTGTGTTGTCAACAGCCAGCCCCAGGTGATTCTC


ATGTGGATGGTCCTTGAACAACATGTTGATGTTGATAAATATAGTAACAAGTGAGGAATGAGTGAATAATTGGTTTATGGAAAATCC


TTTAGAGATACTTAGTTATGAAGTGTTTCCACTCATTGCTTTATTTCTCATAAACATAGTACTCAACTTAAAAATATGTGGTAGTAT


AAATTTTCTCTTAAAACTTACCTGGCACAGAAAGATCTAATAAGCAAAGTGATTTTTTTTTTTCCAAGAGAAGATGTGTATTTGATG


AAATAAACATACTACTCTGACATACTATTTTCTTGCTTTTAAACGTGGTTTTCAGAAGGAATGAATAAATGCTACTAATAGGGTTCA


TTCATAAGAAGCAATTAAATGTATTCAAGAGGAAATTGGTTTCAGGGAGTAGGTCGGATGAAGCCATTTAAAGATAGTAATAGCAAA


GTGAGTCGTATTTTAGAGTGGACCAGATCTGGCTTGACATTTCATTGCACCAGAGGTTCACAGGAAGGAAGGGGTTTGGCCCTCTGG


CCCTGGAAATATGTAAAGGGCAAAACATAACAGACTTTTGTTTTTTCTCTTTGGTGAAGTAACGTCAATCTTGCATGGGTAATCTTG


AGTTGAACATGAAAATAAGTCTTACCTTGATTAACTGGGTAAAATCTTGGTCAGTTTCATGGGCTTTGGAACCAAAGTGGCTCCAAA


TTCTGCTCGGAACTATCAGTGTGACTGGGCAACTCACATCACCTTCATTTCCTTATAAGCGGGAAATAATACCTGCTTCACAAGCTC


ATTGTAAGGATTGAGAGTTAATCCATTTATGTCTGAGGTTGCAATTTTTTGAATTTTTGCAATCAGACCTTGGCAACCACCTTGAGC


AGAAGGGTATAAAAACTCCCACATGCTTAGCGTTCCAGTAATCGAACACTAGGCATAAATAACTACTGCCCATAGGGCTCTTACAAG


AATTGTCTGGTGTATTATAAGCACTCAACAATTATTAGCTTTTTCTCCTCCTCCCTTTCCTATTATTGTTGTTGTTATTATCATTAT


TATGTTTCAGTGCTTTCAAATCGTATTTTGCCTTTTGGAATCCTACAAATTTTCAATGATGGTTTTTTTGGGATTGGTTGTGTCTAA


AAATACGTTCATTAATGCCTCTCTGTATAGGAGGAATCTAAAGTCTTAAGTGTGGCGTTAGTCTTGTGTATTTATGATCACTTCCTC


GAAGTAGGCTGCCATCACTTATGTAACATTGACTTTCTTTCCCTCTATCAAAGAGAAGCTCAGACTTGCTTCAGGGAAGTATGTTGA


GAATTAATGAATAAGTTAATGTTTGTGGCTCTACCCCATTAACTACTAATTAATGTAAGTTACTGCTCTTATAGTTCTCCAAGTACT


ATCGTCATACTGATTCTCTGAACTAGGGACAGGGACATTGAGAAGACTTTTTCTTATGTACTGTGGGGAAGCAGTGTTTTGTAAAAT


TTTTGCTCTTGCTTTTACAACAGAGTATCACTCCGTATCTAAAATTTTACACCTCCTCTACAAAACAAACAAACAAAAAACACAGAA


AAACCCAACCTAGATTAAATCAAGTAACTTCTTATGGAGCTCTTAGTAATGAAATGTTACTTATGTTAATACGTATTTTTTTTTCCT


CTGGGAAACCATTACTTTCATTCTTGACTTTATCTCCTCATCATTATGCTGCACTTAGTCTGTACTTGGCAATAATGTTCTAAAAGC


TCTCATAACAGTTCCATGAAGGCATAGTGTGGTAGAGGCAGTCCTAGCGTTGTGGTTTGTTTTTTTTTTTAAAGGTTTGTATTTCAA


TTCTGTGTTTCTAAAGGTAAGATTTGGATCTTCTGCCCCTGAACTTTTGTCTGTAAAACAGGGATGGTAATAACTTCTATTTGGGTT


TTTGTAAGGCTTTGGAATAACATATATGTCAAATACCAGGCCTGAATACCAGCAAATGTGGCTGATTGTGACTAATGCAATGATTTT


ATTACTTTTTTTCAATATGATTCAATTTGGTAATATAATTAGAACCAATTTCATAGTTTCATATAAAGCAAAAGAAGGTATTTATAG


GGTCCTAACATCAATCATATTTCCACCTGACATAGGCTTACCTTAAATAACTAATATCCAAACTTACTCTGGGAGGACACCTCTTCT


GTAAATGGATAAAATTGAACTTTTCAAAGTACGTGAATACAGAGGAAACATGGAATTGTATATATGTATGTGTGCATGTGTTGTTTT


CAAATAAGTAACTCACTGTAATGAATTACAGTCAATTTTAAATTTCCCAATTTTGTATTAATGTTGAAAGCCACCAAAGGAGTAAAG


GGATGGGTTGTATCTCAAAAAGGCCACCGGCCTGAGCTAAAACTGTTTCCTATACTCTTCTAAAGGCAATGTTTATTTAATCCCAAG


AGTCCTTTGTTCTCATGATTACAAAGTTAAAATTTAATTATTTGCATTGTAGACTTGAAAGGATTAGCTACACTCGTGATTGATATG


TAAAGAGAGTTTTATAATCTCTGGAACTATGGCTTTTGAGGAACAAAATAATTTAAGCTATAATTTTGAAGTGGGACAGAGGATATT


ATTACAGGTTTATTCATAGGATTCTCATCTTTTGATTGGACTCTAATTAAATACCTTCTTGTCAGCAGGGAGGGTGTGTGGAGGAAT


TATGATTCTCCTGCTTTAATCGTTGTTGATTTCTTAGTGATACTTTGAAGTGGCATCCAACTGTCTTCTCCAGCTTTCAGACCCTTT


GATGAAACAATAGAAACTTGTTAAGTACATGACCAGATTCTTTTCATGCAGTTCCCTTGGGGGAGGTCTATTTTAAATTAGATAGGT


TTGATGTCCAGTCTGAAAAGCATTTATTCACCAGTTCTGATAACAGGTCAAGTAGTTTAACCTCTTACACATAAGACTAAGGGAATT


AAAACCTTTCCTTTCCACCACCACTACCCTCCCCTCCCCTAAAAAAGGAAAGGAATTTTAAAAAGGAAAAATGTAGAAAGAAGTAAA


ATGGTGTTTATCCTTTTTTGTTAAAATGTCACAATTTAGACCATTTACAAATCTGTTTCTTATTACAAAATGATGAGTCTCTTTTGT


CTTTGCTCAGTCTCCTTCCTCTTAGTCCACCAATATTATAATTTTGTTAAATTCTGCTTATCACACTCCTTCCTGCAGACACGTTTT


CTTCTGTCCCACCACTCATTTTCAGAGCTCCTAAAAGTTCAGAAGCCCCTCTTTTCTATACTTTGCACTTTCTCTCATGGAATCTCT


TCCATGCCCATGACCTGCTGAGTCTCAAAGTTTAACTCCAGAGCTGACTGACCTCATTTTTAAGCCTCAGACTGACTGTCCTACCTG


ACATGTCCTCTTGAATGTTTTAAAAGTCATGTCAGACCCATCGGTTCAAAACTGAACTCATGTTCTCTCATGAATGCTGGTTTCTAT


GACTTTTTTTCTAAGCACAACTCTATATCTCATTTGCTTGAAGCCCTCCAGAGAACCCTCAGACATTGCTGATGGGAATGAAAATGG


CGCAACCACTGTGGAAAGTGTTTTGGTGGACCCCCAAAAAAGTTAAAGAATTACCATATGACTCATCAGTTTTACCCCTAGGTATAC


ATTTCCAAAAGAATTGAAAACAGGTGTTCAAATAAAATGTGTGCATGAGGCTGGATGCAGTGGTTTATGCCTGTAATCCCAGCACTT


TGGGGATCTGAGGCGGGTGGATCACTTGAGGCCAGGAGTTCGAGACCAGTCTGGGCAACAGGCTAATTTGTCTCTATGAAAAATACA


GAAATTAGCCAGGCATAGTAGTGGGCACCTGTAATCCCAGCTACTTGTGAGGCTGAGGCACGAGAATCATTTGAACCTGGGAGGCAG


AGGTTGCAGTGAGCCAAGATCGTGCCACTCCATTCCAGCCTGGGCAACACAGTGAGACTCTGTCTCAAAAAAAGAAAGTGTGCATAA


TGTTCAATAGCAGCATTACTCATAATAGCCCCAAAGTAGAAACAGCTCAGATAATTGTCCCTGATGAATGGGTAAACAAATTGTGGT


ATACCCATACAATGGTATAGAAAGGAATGAAGTAATGATACATGCTACAACATGGATGAACGTGGAAAACATTATGCTAAGTGACAA


GCCGTACACAAAAGGCCACATATTGTATGTTTCTATTTATATGAAACGTACAGAATAGGCAAAAATCATAGAGACAGAAAGCAGATT


AATGGTTGCCAGGGGCTGCGGGGGGGGTGGGAATGAGGTCTCCTTTTGGGATATGAAAATGTTCTACAATCAGATACTGGTGCTGGC


TGCACTATATTGTGAATTTACTAAAAGCCACTGAACTGTGCACTTTAAAATGGTGACATCTGGCCGGGCGCAGTGGCTCACGCCTGT


TATCCTAGCACTTTGGGAGCCTGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGAGCATCCTGGTGAACATGGTGAAACCCCGTCT


CTACTAAAAATACAAAAAAATTAGCCGGACGTGGTGGCGGTTGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGGATGGTA


TGAACCTGGGGGGCAGAGCTTGCAGTAAGCAGAGATCGCGCCACTGCATTCCAGCCTGGGAGACAGAGCGAGACTCTGTCTCAAAAA


AAAAAAAAAAAAAAAAGTGACATATTGGTTCCCTAGGGTTGCTGTAATGAAGTTCTAGAAACTGGGTGGCATAAACTACAGAAATGT


ATTGCCCCACAACTCTGGAGGCTGCAGCTCTGAGATGAAGGTGTCACAGGGTTGGTTTCTACTGATGGTTGTAGGGAGAATCAGCTC


CGTGGCTCTCCCCTAGCTTATAGTGGTTTGCCAGCCATCTTTGTCATTCCGTGGTGTATAAACCTGTCACCTGACCTCTGTCTTCAT


TTTCACATGGTGGTCTCCTTGTGTGTGTGTCTGTGGTCCAAATTTTGTCTTTTTATAAGGACACAGTCATACTGGATTAGGATCTAC


CCTGAACGACCTCTTAATTAAGTATACCTGCAATGATTCTATTTCCAAATAAAGTCACGTTTTGAGATGCTGGTAATGACTTCAATA


TGTGAATTTTGGGGATATGCAGTTCAACCCATAACAGTGACTTTTATGTTACGTGAATTTTCAATTAAAAAAATGTATATAGACAAC


CCCTCCAGGGACTTCTAAGTGCTGTCAAGCACCAGACCAGCAAAGCACCCAATGTGGTCTGACCCCTGCCTACCTTGTCAGCCTTTT


TACTCTCCTCTCACTCTGTGCTGTTTTTTCTGTGCCAGCCACACTCCCTCTGATTGCAGTGCCTGTGCCTACAGCCTGCTTCTCCCT


CTCTTTCCATTAATGGAGGTCTTTTCACCCTTCAGATCGCAGCCCTAATGCTACTTTCATGGAGAGCGCTCGCATGACTTCCTGGCA


CAAGGCAGCCTCTGTTATATGCAGCACCTTTGTTCTTATTGTCGACTGCTGTGTGACAAAGCACTTCTAAACACTGTGGTGTTAAAC


AGCAACCACTCTTAGGCTTGTGGACTCTGCAGGTCAGGAATAGAGACGGCCTAGTGAGGAAGGCTTATCTCTGCTCCATGATGGGAG


AATGTGAACAGCTGGAGGCCAGAATCATAAGGGAGCTTCCTCAGGTGTGTATGCCTGCTGTCTGGACTGGGATGACTCCAAGACCAG


CCTCAGCGGGGACTGTTGACCATGGCTCCTACTGTGGTTTCTTCATGTGGCTTAGACTTCCTCACGACTGGGTGGCCTCCGGGTGGT


CAGACTTCTCACAGGGTAGCTCAGGGTTCCAAGAGTGAGCTAAAGAAGCTGCATGGCCTCTTATGACCTAGCTTTGTTACATAGCGT


CATTTCCAACATGTTCTATTGGTTAAGCTGTCATAAGGCTGCCCATATTCATGAGTGAGGGGACATAGACCTCACCTCTCAGTGGGA


GGAGTTTCAGAATTTGCAGCCATGTTTAAAAACTGCCCAAATTCTCCATGCTACGTCTAAATGTTTGTGTCTCCCAGAATTCATGTG


TTGAAACCTAGTACTCAATGCAATAATATGAGGCTTTTAGGAGGTAATTAGATCCTAAGGGTGAAATTGGATTAGTGCCCTTATAAC


TGAGGCTGGGGAAGCTTGTTTGCCCCTTCCAACACGTGAGGACGCAGTGAGAGTGCACCATCTGAAAAGCAGAGATGAGCCTCGCCA


GACGCTGAATCTGCTGGAGCCTTGATTTTGGACCTCCCCACCTCCAGAACTGTGAGAAATACATTTCTATTGTTTATAAGTTACACA


GTTTATAGTGTTTTTATTATAGCAGCCTGAACAGATGGACACTCGTCAATCTGTGTTCCTTCACGGTGCTCTTTTCTAATTACTCAC


TCCTTTGCATCATTATTTGATTGACTTCTGCCTTTTTAAATAGGCAGTAAGCTTATTTTGCTCACTACAGTATTGCCAGCAGCTAGC


ACAGTAGCTGGCACATAGATGGTTTGTAAGACTTTGAAATAAAAGTTGACTGGGAAGAATTAGAAAAGGTAGAGCAAGGAAAGCCAT


TTGCTTATATCATAAACATCACAAGCTTGTGCAGCTGATCCAAGCATGATCAACAGCAAATATGCCCAGTGGCCTGTAGGTTTATTG


TTTCATGCTCATGATCTCAGTTTAGCAGTAAATCTGAGGCTGCCTTGTGAATATTGATACTGCACGAGATGTCTGAGAGCTGCCACC


CAAGAGACAGTCATATTGACGCCTGCAATAAAATAACAGCAACAGAAGTATAAGCAAAGCCAAATGTCTCCTGAATGAATTTCCCAA


AAGAGATAAGCAGAATTAAAAATTTAAGGTTTAAATAGGCTAATACTGATAGAGTTTGTGTGTGTGCTCGTGGATTTTTATACTTGT


TGGGTGAAGAATGAGAGGTAGTAGGAGATACAGTTTTTTATTTTTAATGACTCACTTTATCAGAGCTTTATGGGGCTGATCATGTTT


ATTTAATACTCTCTGTAGAATTTAGAAAAAGATTATCTTTCCCTTCTCCTTGGCTCCCCAGTTTAAAAAAAAATTTCAAGTCTGAGA


CAGAGGCACGTAAAGCCTTGCCTAGCACACGATTCACTTGTCCCCCGGCTTCTGCACAGCTGCTTTACAGCTATGCTATAGACTTGT


TAGATGAGTGCCAATTTCCCTGTCTTTGCCTGTAATTTTCAGGGCAGTCAGTTACACAGAACCTCTTAAAATGGAAGGTGAATTGCT


GCTTACTAAATTAAAATGCAGTTTTAGTTTTTGCTCCTACACACTGAAGACCCCAAGGCAGTGTGGTATAATATGAAAAACACTGGC


TTTAGAGTCCCGTGGACCTAGGTTTGAACCTTGACTCTGCCCCTTTTATTGATATGACCCTAGGCAAGTTACTTATCCTTCATATGC


CTCCTTTGCTTAAAAAAAGGAGGAGGTAATAACAGAGGTGTTAGAAGAATTTAGTGAATCGTACATATAAAGAGCCTAATGCAGTTT


GCCACGTAGTGAAGCTCAATCAATATTAGTTATTACGACTGCTATTATACAAATGTAATTGCTTGGGGTTTACTTAGAATTTGTATA


TAGTAATACTTGAATGGCTTTCAAAGAATGCTTGATTTTATTCTGGTTTTGCTCTTAATTGGAAAGTAAGTTCACAGTGCCTTAGGT


CTGAGGTATTAGTACATTAATAGTGTGATTATTCCTACTTTGTCTTTGTTTTATACTGGTGACTTTTTTTTTTGAAAAGCATTTATT


AAAGAATAAATATAAATTGAAAGGGGAAATGGTCCAGAATTCTAGGACTTTAGAAAATTGAATGCACTTTTCTACATTTTTCTAAAC


ATCTGTGGGAGTTAAAGCTGCCAGATAGAATGCATGGACCTGTTTGCTTCAGGATGTTTGATTTAAAACAGTGGTTCTTCCCTTTCC


GGACAGGGTCAGAATGACCTGGGTTCTCTCCAAGGTTGTGTACAAGAGCTCCACACCTTCTGTTCAGAAGACCAAGGACAGTGGCAG


ATGCCATCGCCTGTTGTGAAGTGAAGTTGGAGGAGGGAGAATTCTAGAACAGATGGTTTCTTGGATATCTGGGGCCTGTCCAGCTCT


AGCTTTGAAAATGATGGGCCAGACCTTGAACTGGCATGGATACAGGCTTAAGTGCCAGAACAGGAAGTGAGGTCCTAGGGTGATGTC


TTTGGGGCAGCTGCTGCTACTCAGCTGGTGGGCTGGCACCGCTAGCTTTGGCTTCCTATGGTTTGGTGAGGTGATTGTGTGTGGTAC


AATAACAACAGTGAGGTGGGAAACTGGGCCTGCAATCTGAGAAGGCCATAACCACTTTGGAGCTGTTGGCCTATTTTAGAAGGGGTG


TCAGCTACTGTGCCTTGCAGGACATGTGCTACCTTTGGCATGACGGATGCATGAATGTGGGAGCCAAGGATACATGCATCCCCTAAA


CACTGATCAGCCTGAGTTCTGGCTTGTGTAGAGCAGTAAGCAGTGCTTTGTGGGAGGGCTTGGCTGTCCCCTTTGACATTAGCCTCC


AAAGACTAGGAGCTTATCACAGACTTTGCTAACATCCTCTGATACCTTTTTGGAATAATTAAATCATTCTTGGCTAGGTTCTGCTGT


TTGTCCTGCCTCTCACTAGCTGGGTGTCCTTGGGCGAATTACTTAATCTCTCTGTGCCTAGCTTTCTTTATGTATAAAATGAAGAGG


CCAGACTAGATGATACCATAGATGTGAGATGATCTCTGATGTCCAAATCTGATTAAATAATTTTTAGGTATACATGTATTTTGGTAT


TTGCTTTTTTTGAATAGTGAGTCCCACAAATATTACTTCTGTGTAAGTGACACCTACACCCTTTCTTTTGTTCATAAATTCTTTCTT


AAAGATTTCTGTGAGCTCTAATCCCAGTATTTTGGGAGGCCAAGGCAGGTGATTGTTTGAGCTCAGGAGTTCAAGACTAGACTGGGC


AACATGGTGAAACCCAGTCTCTACAAAAAATAAAAAGAATTAGCCAGGCATGGTGGTGCACACTTGTAGTCCCAGCTACTCGGGAGG


TCGAGGTGGGAGGATGGCTTGAGCCCAGTAGGTCAAGGCTGCAGAGCAAAGACTCTGTTTCCAAAAAAAAAAAATTTACGTGGAGCT


TCTCAATATCTAGTATTCAAGAATTTGGAAATTGGAGTGTATCGTTATTTTATGGAGAGAAGGACCCATTAATTCCCTCTCTCGTAA


ATGATCTTGTCCCATTTGTTGTTGGAACAATACTGGTTGCAACTGTTGTTTGAGAGGCAAAGTATGAAAAGCATGGTGTCGAATTAT


AGAAACATATTATTACAGTGGCACTAGAGGCTCTTCATACTAAGAGGAGGAGATTGAGGCCCAAAAATGTTTCAGGGTGAGTCTGAG


GCTGTGCGCTATGCTCCCCTTGAGAGTGGAGGCTGTGCTTTGTTCATCTTGCCATCCAGCGCCTCTTGGGCTGGTTTTGTTTTATTT


TGTTTTGTTTTGTTTTTAAACAGCTCTTGTCAGAGTGACACTAGGTAAAGATCTCTCTTTAACTTCCCCTTGACCTGTTCGATGCTG


AAATGCCGTCACCCATATTTCTAAGCATTATTTCAAGGTAGCACAAACTCCAGGAGCCGTGGGTTTCCTTTTCAGCATGGTCTGTGT


AAACATGGGCTGTTTCTCAGAGGCTGGGCTGAGGCCCCAGAAGTTTTCTTCATAAGGGGTCACCTCTTACCTCTGCCCCTACAATTC


CTTTTCTATGAGGTTTTAATCTCCAAGAGGGAAGCAGAGGTATGGTTCTGAGGAGTGATGTGGATTCTGGGGAATGCAAGGGAAGCA


AGGGCCAAGTGGGTTGAGCTAACGTGGGGACTGAGAAACCATAGTGAGGGAAAAGGACAAGCAGAAGGAAGGGCCTTGTAGAACCAC


CTAGTGCTTGGATAAGATTCTTCTGCAGAGCCCTGGGAAATTGGAAACACTCTCCGGGGTGGTGTGTGCACTGGCAGTTGAATCTTA


GCATCTTCGTTGTTTCCTTTTGATTTCACTTGTTCTGCTTCTTCTCTTGCTGTAGTTGCCACGTGCCCTGACATTTCGCAGAACTTT


GTTGCCATCCATCCAGATTTGGCCATTTCTCCTTTAATTCCACCTGTTGCCCCTCATTGTAAGTGTGACACACTTATCTTCTTTGGT


TTATTCTAAGGCATTAACTAAACATGTCTGAAATTCCGACGAGTCTAAGAATCAATATGTGTGTGTGTATACAAAAAGTAATTCTGC


CTCAGCCTCCTGAGTAGCTGGGATTACAGGCATACATTACCACGCCCTGCTAATTTTGGTATTTTTAGTAGAGACAGGGTTTCGCCA


CGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTAGAATTACAGGCATGAGCCA


CCATGCGCCCGGCCATCAACGTCTGTGTTTAATGCCAGGTTTTTTCTTTTCCCTAAAAGCATTGTTCGGAAATCTCTGCATTTGAGA


ATCTAGAAATAATGATAGTCAAACACGGGACATTTTTAGTGAAGAGAAGCTGAGTGATTGAGAACAAAATGATTGGAAAGAAGGGGC


GATGACAACCTTAAAGGTGGGAACAATTTGCTAAGAGAGAGGGAAAAGTACTGTATTGTCATTGTCCCTGAGGTTTCCAGGCTTGTG


TGAATTTTGAACAGGGGCAGCCTGTCCAGTTGTAGGAAGGTTGTGGCATTAGGCTCTCTTGGTCCCAAGGCACAAAAACTCTGTAGC


AGGGGTTTTCATAGCAGGTTACACGTGGCAAGGCAGATGGGAATCTTGAGAATATCTGAGGATATGAACTGTGGCTGGGCCACACAG


GTATGGGCTGTCACGTGGTTCCCGATCCAAGGCAGCACTGGGGGGTTGGTGACTCTTTCCTCCTTGAAATTTCTGCTACGGTGACTG


TGATGATCCTAGCTAGTTGGCATCATCTCTGTTGAAGTAGACACTTGAATTAAATATGTTGCCCTATGTTGTTGGCCAATAGGGCAT


AGTGTATATATCAGGGAGGATGGCAGCACCTGTTGGCTGTGATGGCATTTAGCTTGGGCCTGACATTCATGAAGGGCCTCAGATTTA


TTACTTCATGTTGTCTCCACATGAACTTGTACGTTTAGTCACAGAGACAAACTGGCAGGATTGAAAGAAGATGGCATTCGTCATCCA


GATTTAAATATGTTTCTCATTAATAGACATTCTGCCTGTAGTGCACTATGAATTAATACATTTTATAAATCTTGTAACTGCCTTATG


AAGAGCATAATTAGTTATAAGTGTTTGGATGTTAGAAATGTTAATTTGTTCAATATAGGCGTTAAAATGTTTTGTCATTTTCTTATT


TTTAATGTTATTGGGAACTTTAAAAAACAAGAGTGGCTCAAGCCCCTCTTGACCTCTTGGAAGGCCCTGCTGAGCTGGGTTTGCATC


GGCTGTTCTGGGTCATATGTTCACTTTGGGTCCAGTTGGCTGGGCCTAGGGTTTCACAAGGTGTGGAAACCTTTGTCCCCCATATGT


AAAATAGCCTGGCTCCATTTCTGTCAGAAATGCAGCCCACTCTACCCGCCACAGCCCAGGCAAGGGGATGGAGCTGGGTCAGTGGGT


GTGACAGGCTGATGACGGAATTGAAGAGGGGGAGCCTGTGAGTCTGACTTACGGGACTAAAGAATAAGGCCCCAGGCAGAATTCTTG


ATTTACACATAAGACTCCAAAGTTTTAGGCAGTTCATTTCAGTTTTCTGCATCTACACTTATAAACTACAGATGAATAACACCAAAT


GACTTTTGAAAACTCTGAAGACTGTAAAACTCATTTGTGCTTTGAGATACCAAGCCACTGCTAAACTACTTTCTTGAAAATGAAATC


ATTGTTTAGGCAGTTGGTGGTTGTTTGGAAAAATTTCAGAGTGAAGGGCTCTAGGAGAAAAAGAGTTCCAGAAATAAGGAGAGGATA


AAGTGATGCAAGGGACCATTTAGCCGGCTAGATAAAGGCTGGAAGTGATAATTGGTTGTGCTTAGGGAGGGATAAAATTGGAAAGCA


ATGTCAAAATGCAGCGTGAGTCATTTTGGGGGGGGAATCTTTGAAATGAAAAACTGGTATTTAGTAGTAACAGCGACCATGCATTTT


AAAATCCATCAACCAGCATCTCTATTCCCCACCCTCAATATCAACCTGTAATAATTTATGCTGTAACCACCACCGAGAGATAGCTTA


GGACTGGATTACATCAGTCACTTTTTTTTTTCTTGGTTGTATGGCAGATATTTTGATGTTTACAATAGGGACTAGAGAATTTTATGG


GGAAAGGTTGGCATATTAACAGTCATTGAAGTAAGCAGTCTGGGACCCTGTTGTGTTATAAGGGAAGGGATTTTGGACCTTGGTGTT


TTGCAGAGGCCATATTTGCATAATTAGAGAGCACAGGATTATGGGTAAAATGGTTGCAACTACTAAACTAGCCTAGTTTATATGGAT


TCTTGTTCATTTGCAAAATACCTTTTCTGTGTGCTTGTTGAAACCATAATATCCTGGGTAGGTTTTATTACAATAACTTATGGTCTA


GTAACATATCTGGAATACCATAAGAGAAAGCATAGGCAACATTTGTAAGCCTGCTGCTTTATGAAGAGATTGTGCTTATCAGAAAAA


TTGTAGCATTACTGTAAATTTTTTCTTTCATATGGAGTGATTTACTTGGTATTTCAGTATATTAATTTGCTAGGAAAATGTCAAGTT


AGTACTTCTCTCAAAAGGGCATTGTGCATCTGAATCACCCGTGGTTTTTTTTTTTTTTTTTTTTTGGTTTTGCCCTCAACCCAGATG


TGTTGTGACTTAATCTCCAGTTCTGGGCCTGGGCACCCATCTAAAATGGTGAAGAGGACAGAAATGATTCTTGACTTCTTGGTGTGT


ACGTCTGTGAGGAACCCAGATGATAACACTGCAGGGGGAACCATAATTGTAATTGTGATAAGTGCTACGGTGAAAAAAAAAAAAAAT


AACACGGGGTAAGAGACTGGCAGAAAGAATGTAGTTTTGATGGGCGGGAAGGCCGCTCTGAGGAAGTGAGACCGCAGCTGAAAACTC


AGGGATGGAGAGGTTAGCCCTGTGGGGGGAGGGAGGAAGGAGCATTTCAGGCTGAGGGGACAGAGTAAGGGAGGCCTGATGTGGAGA


GGGCTTGGTGGGTTTGAAGAGCTGAGATGATTGGGACTTGTGGCCAGAGATAGGGGAGCGGGGGGAGCCCCGCGGGGAGCGGGAGAG


GATGGTGCTCCTGGCAGAGATGGCAGGTGGCCTGCTGTTTCTATTCTGTGCTCCTTAGTGTCTTGGTTATGAAATGACTTGCCAAAA


TGTCCCTTTAAAAGAAAAGGGGTCCTTGCCAGTTACAGCAGTGTCACTGTTTAGGTCTGCTAAGCAAATTCTAGGGTGTCTGATGGC


TTTGTGTTGGGAGTTGTAAATGGATTTCATTTGAGAACATGACAAGAACTGAAAGATTAGTTTAAGCAAAAGAATTTAATTGAAGGA


TACATCATTGTTCTTGTAAATCCTTTGATATTTGGCTGTTGTCTTCCAGCCTTTTCATTCCCTGCATCCTGTCTGCTGCTTGCAGGA


CTGGGCTGTAAGCCTTCATTCACCTACAACCCTTTTGTATTGCTTGGAACTTGCTTGCTTCTTCCTCCTGCTCCTCTTGTTCCCCAC


TCCTCTTCTCCCTTCACCTCCCCATCCTCCTCCCCCTCCTCTTCCTCCTGCTTCTCATCTCTTCAGATGGAAGAGAGATGGGAAAGA


GCATTCACTTAGTTATTCTTTGGAATAAAATATACGTCAGTTTCCAGCGAGGGAATTCTGGCAGATTTACTGACAGGTGACAGTGTC


TGTGTAGAATTAGGATTCCTAGGAAACATTAGTTCTAACTACATTATTGATAACAATGCCATGTGCATTGTAAATTTGGGACCAGGC


CCTGCATGCAGTTGTGTGGTGGTTCCCTACACAAGGGCTCCTGGCTGAAGGGCAAATGAGGGTGGAATCCACTGAAATGCAGCCCAC


TCGCCACCCTCCACGGCCCAGGCCAGGGGATGGAACTGGGTCAGTCTGGAGGAAGAGGGTGTTCTTTTCTGTTTCTTACGCAAGCAA


ATCACCAGGCCCATGTCTTGACTCCTTCAGAGGTGCCAAAAGGGCTGGTGATAGCCCTGCCTGGGACAAACCTCAGTGACTTCTGGG


TCGCACATTCTTGCCTGGGAAGACCCTGTTCTTACCTGGTAAGGCACAATTGAAACTATGATTGGTCCACTTCACAGACGAGGCAGC


TTGTTTTCTCCCCTGGTGTGTTATTAGTTTTAATGGACATATTTGTGCAATCAGTGTGTACAGTTCATGTTGGTAAGCATCTGGCAT


ATTTTCATTATTTTAGAATAATGCTATGCTGAGCTCACATTTCAGCTTCTTGTCAAAAATAGTAATATTCTGGTATGGCAGATTTCC


TTCTGGGGCAGTACTTCCCACCAGTGTGTGCTGCCTGGATATAGTTTCATTCACAGAGGCTGCTTCACATCACATTTCAATGCATTT


GTGCTTTAATAGTTGATTCTTAGTATTAATAAATTGACCGGGTGCTTTCATCTCCAGTTTATAGGAGGAAATTGTGCAAGGAAAAGG


AGGCTAACTCACTTGCCCTAGACAAATTAGAGGCTTGTTTCAGGGTTGGAAAACAGGTTCTCATATTCCTTCTGGAATATGTTAAGG


TGTGGACTAATCTCTTCTGTGACAAGGACATCCCTGAGTAGTACAGTGTGTCCTCAGATCGTAGTCCAGAGTTAAGAAGTCAGGGTT


GGAGGAGTTCCTCTCCCTTCCTCCATGCCTGGCTGTCCAGATGGCTCCGTTTGTCACCATGTCTTAGCCAGTGGTGCAAGTGGCTGT


GTCTTTAAGAGGGTGACCTCAAGTTGGACACATTACATCGAGTCATATCACATCACGGTATAGTCACAGGAACCCCCCCTAGTTCCC


AGGGAGCCTAGGAAATATAGTCTATACCTGGGGAGCGGGGTCAGGGGGAATCACATGCCTGACTAGAGCTAGGGGAGTTCAGTACTA


AAAAGAGTAGCGGGGAGGATGCCGGGGCACTGACTACCACATTAGTCCTCGTTCCTCCCTGAACAGCCTTAGGGTGGGTGAGCAGCC


CTAAGTGAGTTGTTAGCTAACAGAGATGTATAATGAAGGGGCACCACAGAGCATTTTATATTCCTACTGTAGCCCTAAATGAATAGG


CAGCTCTTTGTACATACGCTTGAATATGCTTCTTGGAACCAGTTCATTCACTCGACAGATACGTGCTGAGCGCCAGTTCTTTGCCTG


GGTGCTGTGTGGTCTAGTAATTGAAGGTACCTGTAAGATGGCCAGGGCCAGCCCTGCTCATCATGAAGGGCCTACTTATGTAGATAA


TTTTGAACCTCAAATAGGAGGGAAGTTGGAGTTGATTTACCTGTCATTAAGTTGTTAAAGAAAGATTTTTCCTACTGGTAGCAACTG


AATGGAGCTCTACTATGGTTTGAATGTGTCCCCCAAAGAGCATATATTGGAAACTTAGTCCCCAGTGTAACCGTGATGGGAGGTGGA


GCCTAATGGGAGGTGTTTAGGTCATCAGGGCTCCCCCTCATGAGGGGATTAGTGCTGATTATAAAAGGGCTTGAGGCTGAGTTCGAT


CTCTTGCTGCCCCTCATCTTTTGCATTCCACTATGGGATGATGCAACAAGAAGGCCCTTTGCAAATGCCAGCTCCTCGGTATTGTGT


TTCCTAGCCTTCGTAACTGTGAGAAATGAGTTTATTTCTTTACAAATTACCCAGTCTGTGGTATTCTGTCATAGTGACACAGAATGG


ACTAAGATGAGCTCAGAGGGAGAGAGGCTGTCTAGGCCCGGGGCCTTTGCTGTACAGCAGCTGGGCTAATGCCTCTGCGAAATTATA


TTAGCCTGTTTGTGTTAAATGAGGAGCCCTCCTGCTTGAAAGAGGCAAGGCATTCTGCTTATGAAGCCAGAGAAATCAGTCAGGCAG


CCTCTGACTTACCTTTGCCCTCCCCTTCTGCTCAGAATCCTTCAACTCACTGTCCGTCAGGCTCAGCCCTGTCTCCCCTGGTCTCTC


CCAGACCTGCCTTTCTGGGTGTGGGGTCTTCTTGCCTCCCTAGGTAAGGGACAGATAATGCCTTGACCACCCAGGGAACAGGAGTTT


GGGACATTACCCCTGAACTGAGAGGTGGTGCTGATGAGAGTAATTAAGCACCCAGAGACATTGTCCTTCAATACATTGCAAAGGAAA


GCTTGCTCAGAGTAGACCTGCACCTGGACACGAGAGGCTGGAGACTGTATTCAGGACAGTGCTCGTGGGGAGCTTCCTTCACTGCTC


CACTCTTGTGTCCTGTGTTACAGGGGCTGCTGGCTGTTGCCACTGTTTTTCAGAGAATGGGCTGCCTGTACACACCTGACTTGGGTG


ATCATGTCTACCCAGGAGGACCAGCAAAAAGGGACAAGCAGTGATGCCATCTGGTTTTACCTCCAGCATTCCGAGCACTGCCCTGGC


CCTCTCCCCCAGCCAGTGGTCGGGGTTGGGTGCGCCCCACTCTGGCTGCACAATAGAGTAACGCAGGAGCTTTAAAAACTCCCAACA


CCCAGAGCTCACCCCCAGCAAATCCGACCTAAATAGTCAGGCATGGGGCTTGGACAGCAGTATGTGTATATATTTTAAGGTTTCTTA


GTTGAATTTAAATGTTACAGTGGGGATTGAAAATCTTGGTCTAGTGGTGGTAGCTGTTGGGTTTTTTTTCTTTTCATTTTTTTTGCA


TCCATTCCTGTTACTACCCTCTAGACCACTGTGATTTCTTAGTCTAATCCTGACTTGCTACCTGAAACCCTCTAAATGTAAGTCTCG


TGCAAGAGAGTGAGAGGTAAAGTTTGGTTTTTATGATAAGAGATACCTTGCTCAGTAAGCAGAAATAAGTGCCATGTGTTAGTAACT


ACAGTTTTGTTTTGTTTTGTTTCCTGTGGGAGCGACAGAAAACAGTTTACAGGGTGTGGTGGGGAAAAGAAGAAACGAACATCTCTC


TGAGGGCGAGTATAAGGTTGTGGACTTAGTGGGAAAAGTCCTCAACTTCAAGTCAGAGAGAACTGTCGAGGAGAGAGACTCATGAAG


AAGACACAGTGAGGTTTTTAGTGGTTAAAAACACAGCACTGCGTTTACATAGTCTATTTCCCCCCTAACAGTGGCAACATGTTGTGG


ATTTTCTTTTTTTTTCTTTTTCCTGGAGAGAAGCATGCTGCCTCTGAACAGTGGAGAGGAGGAAAATCATCAGCATCCTCATTGGGG


TCAGGTGACCTGGGCCTCGTTCTTCCGCTGCCACCTGCCAGGGTTGGGATTGTCACAGAAGACTGTTCCTCTCCGTGGTGACTGATT


GCGGAGAGATAAGGGGGTTAGGAACATGCAGCTTGCTGTGCTGGGCTCAGAAGGGACTCCATGTGATTGACTCCAGTGGAGACTTAT


TTTACCTGCCATTTCTGTAGCAAGAAGGAACCCAGATGGGGCCAGGGGTCTGTGAATGCCTGGAAAGTATATGTCAAACATTGTGTG


AGGGTACACATCCTTTTCTGGGGAAGAAGTTCCATGGCTTTTAAAAATCAGAGTCCTAAAGGATCCCAGTGACTAAAAAAAGGAAGT


GAAGAATTCCTATCATAAGTATCTTTATCTGTGATAGGGAACGGGAATGTCTGCCTGATGTAGTCTAGAATCCTGTGAATTCAAACA


GATACTTTGTTCGTTCACACTCCCGCAGCTTATGTCTAGCGTGTTATGCTATAACGAATAGGGTTCTAACATTAAACTTATTTTTTG


AGAAATCTTCAGGAAAAAATACCATCTTATGAATAGGTATAGTATATATAAATTTCATGGCCCGGCGCAGTGGCTCATGCCTGTAAT


CCCAGCACTTTGGGAGCCCGAGGCAGGCGGATCACTTGCGGTCAGGAGTTTGAGACCAGCCTGGGCAATATGGTGAAACTCCCTCTC


TACTAAATACAAACATTAGCTGGGCATGGTGGCGGGCACTTGTAATCCCAGCTACTCAGGAGGCTGAAAGGCAGGAGAATCGCTTGA


ACCTGGGAGGCGGAGGTTGCAGTGAGCTGAGATGGCGCCATTGCACTCCAGCCTGGGTGACAAGAGTGAGACTCCATCTCAAAAAAA


AAAAAAAATTTCATTTAAGGCATCACAGATTGTTTCTTTTTTTTCCCAACTGTGTACTCTAAATACAGGCAAAAAGCATGTAAGGAA


GGTTGTAACAAAATGTATATGTAGGCAATAGGACTGATAAATACAAATAAATCACAAAAACTATATGGAGGAAGGGGGAAAATCATG


CCAAATAACTTAGGCTACTGAGGTTATTTGAGCATTACATTTATAATGAGCTTCCTGGAAACCAAAGTAAAAAGAGAAACACAGTGG


ATGTTAGAATTTCTACTTAAAGATAGCAAATTCTTTCGTTAGGTAAGACAGTCTTTCTGGGGTTCATGTCTAAGACTTTATCACATG


TCGCATTCCTCAACACTTTCACCAAACATACAGAAATGCCTCTCTTGTGATTGCTTTCCACTTCCACAAAACTAGTTGTGTGGGATA


CCCATCTCCGGATGTGTGGTTCTTTGATGAACTCTCTCCCCTGTTTTTCTAAAAACTCAGTTACCTTAGCTGCTGGGAATCGCAGTG


CAAGATTACACTCTGTGGAACTGCCCAGAGCGGGGAAAATGAAGAGGGTGACAGGTGCTTTCCTTCAGGAAATGACAACTTAACAAG


CACAGTGATGGTTTTTTGCTATGGAAATGGAGGATGCTGACCAGAATGTCTGCTGGGATGGCAGGTCCCCCGGCTGCTCCCTTCCCC


CCACTGCCTCACCACCTCCCCCTGCCACACCACCCCACTATGGGGAGTTGAGCTGAGGAGGCCCTTTGCAGCCATCCGTCTGCACCT


CGCCTCTTTAGGAAGTACTCTTTCTTTCACCTTCTTGCACATAATTTACTTTGTGACTACTCATAAATGCCCCCTAAAGATGAAAAC


ATATTTTTAAAGTTGGAGTGAGAATCACCGTAAAGCCTTTATAGAACCAAATGACGTTTCTTTACCAAACTGCAGAGCTTTCTTTTC


TGCTCCTTTTCTTCAAAAAGAGTCACAAAAATTCAGGAATTTTAAAAACCTCTGCATTTAATTCCTCATTGCCTTTCATATATGTTC


AATAATTGCATAAGCTGTCTCACTTAAGCTGTTGCTAATAATAGCTTTTTTGTCGTTTTGGAAAACTATAACCAAGAACCCTAATAC


ATAAATACTTCAAAGTATGTTTTCTTAATAATGGTGTTTGATGTAGGGTGGAGGATGAGGGGAAGTCAAATATTTAGACACTTACAT


AGTTTATGTTTAAGAATTATCTACCTGTATATCCATTATAGTTTTATCCAGAAATAGCATGTAGTGTGGAAAGATGTTTCCGTAACC


TTCCTGGAGTAGCTCATAAAGCAAACCTAAGAATGCTTTGGAAGTCTTTATGGTATGAGTGTTTTGTGTTTGTCCTGTTTTCTTTTG


AAAAGTACAGATCCAAGGGCAAACCTTTCAGAATGGGGTAAGACAACAATTGAACTTGATGAGTTGCCTTATGTAGCAAAGATGGCT


TCAAAGATAAAGGTAATCTGCAGAAATAAAATCAAGCTTCTTTTGCTCTGTGACTGCATCACATGAAAATGGCTAGGTAGATTTTCA


CTCGATTGGAGTTTGTTTAGGGTGGTCTGATTTAAAATGTAGGCTCTTGTGATGTGCATAATTTTAGATGGTCTTGATTGCCCAGAG


CAGCTGTTACTGCTGTGCAGAAACAAGTGTTCAGTGTCCCTTTTGGAGAAATGTGCCGTGTGCATACAGATGCCATAGACAGAGAAA


ACAAATGGTGGTGTCAACATGAGCCCCACCTCAGGTAACAAGGACAAGCTGGATTCCAGAGGCAGGGTTGTGTGGGGACAACTCCGT


GAAGTCCACACAGCAGAGAGGAGCTACAGGGAGGTGTTTATTTCACAATGGTTCGTGATTTTTTTGACCAATGCTGGATGGGCAGCT


AAGATATAGTATCAAAAACACATTAACTATAAATGGGTGAATTTTAAATAGCCACATGTACACCTCCATTTTTAGACTGTTGAGAAG


CCATTAAAAATTAGTTCCTCCTGTGATTATTCACAGGGATGAAGTATTCCGAGGGATTGACAGTTTGTGGCTAAGCCATTTAAAAGG


CTGTATAAACTGGGTATTTTAAATTAGTCTTATAAGTGAACTTCAGTATACTATGGAGTATTTTTCTTAAAAATTGTATGCTTGTCA


TCTTTTGGACATTCTTTGGGTCAGAGACTCAAGTGATTCATGCAGGAGGTCACAGTGAGTAGTGACTGCTGAATTAGGAGGTAGGGC


AGGGCAGAGGTATGTCTCTGCTCTTCTCAGCTGACCGGTCGTGTGTTGGTTACTTTGTCCACCAAACAGTTCTGGCACCAACTTTGG


AAGGGTGATGCGATATTATGCTCAGTGAACTGATTAGTGCCCCCACAATTGAACCTTAGCCAAGTTGTTGGTTGATAATTGGCACAT


TTTTTCTGATATGCTGATAATCCAGTTACTGCTTCAAGTTTATATTAAAATGTTTGACTCTTTCAAACCTTGCGGTTTTTGATGATG


TCAGTAGGTCACCAGACTTTCTGAAAATAGTTCTTTGTTTCAACAACAACAACAACAAAAAAGAGAAAAGAGATAACACATAAGCAA


TAACTTACCATTATTGTTTTTTAAACCTTCACAAACTGACTTCTTTCATGGAAATACTGAAATATTTATTTTGTATTTAATTTATTA


TATAATTTAAAATGTAGAGCGAGTGAATTCAGTTTGGGATCTACTGAGTCACAGTGCCTGGTAGCAGTTGGATGTTGTAAGAGTGAA


GTCTGAGTGGGAGAAAAGGGTTGAGGAATCTCAGCTGAGTGTCCCTGAGCAAGCTGCATAACATCTCCAAGCCTTGGTTTTCACATC


TGACAAATGGCATGAGACCTGCTCTTTAGGGTTGTATTAGAGATTAAATAGTCACATAAGGAGTACTGAGACTGTAGTATGTGCTCA


GTAAATATTCTCTTTTCTCTCTCCCTCTTTTTGGGTATGAAGGTAGTTGTAGTTGTAAAATTTTCTTCCACACTTAGGAACAGATAT


TTCTCTAAATGTAAGCCCCCTGGGCTTATTCTAGTTTGTTCGTACATCTTAAAAATGGAAACCTCAGACTAAATATAGTATTCAAGT


ATAAATCCCACTACTGCCTAGATAATGGTAAAGACATTACTTCATAGTCTTTGCGTGCCTTGTTCCCATTAATACATATCATGTCAT


GTTAGCTGTTTTATAAGACAGTTCATTGCTGATTCATCTCACCAATTCAGTTCCAGAACAGCACCGTGTCAAGGATGCAGTGGCTCT


GTCATTTTGATGACGAGATGTTAGAACAGTTTTCAGTGTAAGAATCTGCTTAGCATTACAAAGCATTCATTTCTGTGGAAAGAAGTC


TTCACAAAGCCCGGGAATTGACTAAAATAACCACCCCTTTTTTAGGGGTTTGGTGTAAAGAATAGAACATATTTGAAGCCTGGGTGA


TTGGTGATGGGGAAAGTTACATGAACTGAGTTTTGGCTTCATTTCCCGGAGTGATGATAATGAGTTTACTGGGTGCTGCAGTACTAC


GAGATCACAGAGTGCCAAGACCTCAGTGCAGTGCTGCGTGATTGAAATGACTGATACTCTCTTTTTTTTTTCATGCTAGTTCAGCCT


GTTTTCATACACTCCAGAGGTTCAGTAACCATCAAACAGGGAAAAGGAAATGGCAGTCCAATAGAGCGGTCGTTCAAAATGACCAAA


GTAATTCCAGAAATTCAAGAAAGTAGTTGTTTCTCAAGTGTCCATTAGGATCGGGCTGTCTTAGAGTCTGCATAACTCGGAAGTGAT


TAGAGGGGTTTTGTGGCTTTTCTGTTCTCTGATGACTGGAGCTGGTTTCAGCCTTCAGAGTAAGTAGCCAGAGAGTAAGATAAGAAA


TGCTGAGGAGCTGAAGTGGGCACCAATTTTATTTTCCATTGTGAAGGAGATGAGCATCTGTAACCCACAGCAAGATCAACCACCACA


TTAAATTTATATTGTTTGAGACAGTTCTGATCCACTTGAGTGTGTGTGTTCCACTAACACTCTGAGATGGTTGCATAGGCCACAACT


GTTCTGTCCAGTTCCTGCCTGATAGGTAAGCTCTCTGGGTAACTTTATTCCCATGAATTGAGATAGCAGAAGACAAACACCACAGTG


GCATTGGTGTATCCAAGGCACTGATTTTGTTTTTCTTCCATGCGCTAGTTTGAGCTGGCCAACTAATCATGGTATTAGCCTCAAAAT


GTATTGACAACAGATTTGTTTTGATAGCAAAATTGCTTTTATACTTGAGAAATCTGATCTTTTATAAAAGGCCCAGGGTAAATGTCC


TTTAGCAACATCATGAACATGTGTGATATCAGTGATATGGTGGGGAGATGTTCCTCAGCAAAGGATGTCTGTATTTGTTCCTAGGAT


TGACAAAGCTGTAAAGCAAAGTGCCTGGTAGGGGGGAGTCTAAAGGAACTAGTAGGTAAAATGATTAGAGAGCTTACTGTAGTACAG


ATGGCGATATGCAGTCTACAAATGACATCTCCTTGCCACCACTGTTACTATGGGTTCTAATGAAAAGAACCTGAGACTTTTGAGAAT


TTTTGAGTTCAAAGGTATAGAAGAAGGAAAGAAGCTGTGAAAAGCAGGCATAACATTGAGGGACAGAGAATTTGGCTAGGTAGGTCT


AGACTGTAAATACAGTAAACTTCCCACACTACAGTGGTAAAGTAAAATTTTCCCCACTTTACAGCATACAGCCACCTTCTCGCCATA


TTCCAAACTTTTTCATTGCTATTATACCTGGTATTATTTCACTTCACTTTATTGCATTGCTCTATGTCATATGTGTTAGGAGCCTGT


TTGGAAGAAGAGCAGCATTGTAGAATTATGGAGACAGCCATCTCTTGCACCCGTGTTTGAGCATCTTCATTTAAAGGGGTTACCAGT


CCCTTGCATAAATCTCTATTTAATCAGCTTGCTTTCCTAATCTTCTGCATGAGCAATTCTGTCGCAGGGCAAAACCGTTGATTGTAG


GGGAAGAAGAGAGGGAAAGGAGAAAAATGTAGTTTTGGAAACAGAACACTTCAAATGAGGGTAGGCCAGGTTCTGTAGCTTCCTCAG


GGATTTAGAGTAGGGTTGATATGAGAGCTGTGAGTACCTAGGCATCTGTGGAGAAGAGGGAGTGGAAGAGAGGTAAGTGAGGCTTTG


TCAAAAAGAAATTTTGAAATGAGTAAAGTGTTTCTGGTTTTGCCAAAAAAGGAGAGGAAATTCTCAATAACCTTCTTATACCACAGG


CTTCCTCCTTATCAGACCAATAGTGATCGTATCAGACATGCTGCAGATTAAAAAGACATTTGTGGGTCAACCTTTAATTTTTACCAT


TAATCACAGGAATGCTTTGTTTTATTGTGCTTCACTTTATTGCTCTTCACATATATTATGTTTTTGGTTTTTGGGTTTTTGCTTCCT


AACAAATGGAAGGTTTGTGGCAACCCTTCATGGAGCAAGAGTATCAGTGCCATTTTTCCAATCGCATGTGCTCACTTCATGTCTCTG


TGTCACATTTTGGTAATTCTCACGACATTCCATACTTTTTCATTGTTACTATATCTGTTATGGTGATCTGTGATCAGTGATCTTTGA


TGTTACTATTGTAATTGTTTTGGTGTGACATGAACCACGCCCATGTAAGAAGGCAAACTTAATAAATGTGTGTGTTCTCACTGCTCC


ACCGACTGGCCATTCTTGTCTCTCCTCCTCAGGCCTCCGTATTCCCTGAGACACAACAATATTGAAATTAGGCTGATGAGTAATGGT


TTCTCAGTGTTTAAGTGAAAGGAAGAGTCACATGTCTCTCACTTTAAATCAAAAGCTACAAATGATTAAGCTTAGTGAGGAAGGCAT


GGTGAGAACTGAGATAGACCAAAAAACTTGGGCCAAACCATTAGCCAAGTTGTGAATACAAAGGAAAAGTTATTGAAGGAAATTGAA


AGTGCTATTCCAGTGAACCCATGAATGATAAGAAAGCAAAACAGTCTTATTGCTGATATGGAGAAAGTTTTAAATAGAAGATCAAAC


CAGCCACAACACTCCTTAAACAAGAGCCTAATCCAGAGCAAGGCTCTAACTGTCTTCAATTCTGTGAAGGTTGAGAGAGGAGAAAAA


AACTACAGAAGAAAAGCCGGAGTCTAGCCAAAGTTGGTTCATGAGGTTTAAGGAAAGCAGCCATCTTCATAACATAAAAGCGCAAGG


TGAAGCAGCACGTGCTCATGTAGAAGCTTCAGCAAGTTATCCAGAAGATCTAGCTAAGATAATTGATGAAGGTGGCTACACTAAACA


ACAAATTTCTGATGTAGATGAAACAGCCTGCTATTGGAAGAAGATGCCATCCAAGACTTTCATAGCTAGAGAGGAGAAGTCAGTGCC


TGGCTTCAAATGACAGGCTGACTCCCTTGTTAGGGGCTAATGCAGCTGGTGTCTTTAAGTTGAAGCCAATGATCATTTGCCATTCCG


AAAATCCTAGGGCCTTTAAGAATGATGCTGACTCTATAAATGGAACAACAAAGCCCAGATGACAGCACATCTGTTTATAGCCTGGTT


TACTGAATATTTTAAGGCCACTGTTGAGACTTATTGCTTATAAAAAAGATCCTTTCCAAAATATTACTGTTCCAGTGTGATAATGTA


CCTGGTTACCCAAGAGCTCTTATAGTACAAGGAGATTAATTTGCTTTCATGCTTGCTAACAAAACATCCATTCTGTAGTCCATGAAT


CAAGGAGGAATTTGACTTTCAAGTCTTATTATTTAAGAAATACATTTTCTAATGCTGCCATAGACTATATAGTGATTCCTCTGATTG


ATATGGGCAAAGGAAATTGAAAACCAGGAAAGAAGTCATCATTCTAGATGCCATTAAGGTCCTTCATGATCCATGGGAGGAGGTACA


AATATAAATATTAACTGGTGTTGGGGAGAAGTTGATTCCAACCCTCATGGATGTCTTTGAGGGATCCAAGACTTTAGTGGATGTGGT


ACAGCAGATGTGATACAGATAGCAAGAGAACTAGAATTAGAAGTGGAACCTGAAGATGGGCCTGATTGCCACAATCTCATGATAAAA


CTTGAATGGATGAGGAGTTGCATCTTATGGAGGAACAAAGAAAGTGGTTTCCTGAGATGAAGTCTACTCCTGGTGAAGATGCTGTGA


ACATTGTTGAAACGACAGCAAAGGATTTAGAATATTCCATAAACTTAGTTGATAAAACAGGGTTTGAGAAGATTGACTCCAGTTTCA


AAGACGTTCTACTGTGAGTAAAATGCCATCTGACAGCATAACATGTTACAGAGAAATCTTTTGTGAAAGGAAGAGTCAATCAAATGC


TGCAAACTTCATTGTTGTCTTATTTTAAGAAATTGCCACAGCCACCCCAACCTTCAGCGCCACCACCGTCATCAGTCAGCAGCCATC


AACATTGAGGCAAGGCCCCCCACCAGCAAAAAGATTACGATGTGCTAAAGGCTTAAATGATTTTCAGCATTTTTGGCTATAAAGTAT


TTTTAAATTAAGGTATGTACATTTTTTAGACATGATGGCATTGCACACTTACTAGATGCAGTATAGTATAAATATAACTTTTATGTG


TACTGAGAAAAAAATTGTGTGACTCGCTTTATTGCAATATTTGCCTTAGTACTGTGGTCTAGAATGGAACCTGCATATCTCCAAGAT


ATATCTGTAGTGTGATTATTTTGGAAAACCATTTAGTAGTTACCCAAGATAAGTTAAAACATGTCCACAAAAAAGACTTGTATGTGA


ATGTTCATAGCAACATTATTCACAGTGGCCAAAAACTGGAAACAACCCAAGAATCCATCACCTAGTGAATGGTTAAACAAATTGTGG


TATATCCATAAAATGGAATACTACTCAGCAACAAAAGGGAACAAATTTACAGATACATACAACAGCATGCATGAATTCCAGAAAAAT


TGTGCAGTCAAAGGAATAAAACTCAGAAGACCACATACAATGTTCATTCATATGAAGTTCTGGAACAGGCAAAACTAGTCTGTAGGT


ACAGAAAGCAAATCAGTGGTTTTCTGGAGTTTGACATGGGGGTACTAACAAGGGAACTTTTTGGGGTGGTGGGAATGCTGTATATTT


TGATTGTGGGGATGGTTACATGGTTGGATGCATTTGTCAAAACACACTTAATGGTAATGCAAAATGAATATATTTTATTTTATGTAA


ATTATACCTCAAAGTTGAATTTTTTTAAAAAGTTTCTTTTAAAAAGTAAAGACATTTGTGGTGCTTCTTGTAAATTTTACTGCTGAT


TATGACCTTGTTTCTTTAGATTTGACTTTCCAAGTTTGAAAAGACCAGTTTAAAAATGACTTTTGCTGGGCATGGTGGCATGTGCAC


GTAGTCTTACCTACTCAGGAGGCTGACGCAGGAGGGTCCCTTGAGCCCAGGAGTTGGAGGCTACAGTGAGCTATGATTATGCCACTG


CACTCCAGCTTGGGTGAAACTGTGAGACCCTGTCTCTAAAAACAAAAATAAAAAAAAATTAAAATGGCTTTTTAGATTATAATCTAT


ATGAAATTGGGGGTTATTTCGCACTTTTATATTATTTGTCCATTTTGCTTCTTTCTAAATAGCCTCTGGATTGTGTGTTATTTTCAG


AAAGCTCTTGGAGATTTTTTGAAGTGTATGTTTTAACAGGATTTTCCTGTTGCTCTTTGGCAAACTTTGTCCTTTTATTGTTTAAGG


AGTATAAATAACAACAGAACAGAATTACTTTCTGGTGCATTTTCCTCTTCTCCTGAGTCTTTTATGTTCAATAACTCTGAAGTTCCT


GTTATTCCTGCCTTTGAACGTAGAAAATGAGACTCTCTCTCAAATACCTGAAACTAAGGCACATAAAAAATTTAGGAGGGGCCAGGC


ACGGTGGCTCATGCCTGTAATCCCAGTACTTTGGGAGATTGAGGCTGAGGTGGATGGATCGCTTGAGCTTGGCAGTTCAAGACCAGC


CTGGGCAACATGGTGAAACCCCATCTCTACAAAAACAAAAATTAGCTGGGTATAGTGGCACGCACCTGTAGTGCCAGCTACTTGGGA


GGCTGAGGTGGGAGAATTGCTTGAGCCCGGGAGGTGGAGGTTGCAGTGAGCACAGACCGCGCCACTGCACTGCAGCCTGGGTGACAG


AAGTGAAAAGAAACACTGTCTCAAAAAAAAAACAGGAGGGAGGAGCCAAGATGGCCGAATAGGAACAGCTCCGGTCTACAGCTCCCA


GCGTGAGCGACGCAGAAGACGGGTGATTTCTGCATTTCCATCTGAGGTACCGGGTTCATCTCACTAGGGAGTGCCAGACAGTGGGCG


CAGGCCAGTGTGTGTGCGCACCGTGCGCGAGCCGAAGCAGGGCGAGGCATTGCCTCACCTGGGAAGCGCAAGGGGTCAGGGAGTTCC


CTTTCCGAGTCAAAGAAAGGGGTGACGGACGCACCTGGAAAATCGGGTCACTCCCACCCGAATATTGCGCTTTTCAGACTGGCTTAA


GAAATGGCGCACCACGAGACTATATCCCACACCTGGCTCAGAGGGTCCTACGCCCACGGAATCTCGCTGATTGCTAGCACAGCAGTC


TGAGATCAAACTGCAAGGCGGCAACGAGGCTGGGGGAGGGGCGCCCGCCATTGCCCAGGCTTGCTTAGGTAAACAAAGCAGCCAGTA


AGCTCGAACTGGGTGGAGCCCACCACAGCTCAAGGAGGCCTGCCTGCCTCTGTAGGCTCCACCTCTGGGGGCAGGGCACAGACAAAC


AAAAAGACAGCAGTAACCTCTGCAGACTTAAGTGTCCCTGTCTGACAGCTTTGAAGAGAGCAGTGGTTCTCCCAGCACGCAGCTGGA


GATCTGAGAACGGGCAGACTGCCTCCTCAAGTGGGTCCCTGACCCCTGACCCCCGAGCAGCCTAACTGGGAGGCACCCCCCAGCAGG


GGCACACTGACACCTCACACGGCAGGGTATTCCAACAGACCTGCAGCTGAGGGTCCTGTCTGTTAGAAGGAAAACTAACAACCAGAA


AGGACATCTACACCGAAAACCCATATGTACATCACCATCATCAAAGACCAAAAGTAGATAAAACCACAAAGATGGGGAAAAAACAGA


ACAGAAAAACTGGAAACTCTAAAACGCAGAGCGCCTCTCCTCCTCCAAAGGAACGCAGTTCCTCACCAGCAACAGAACAAAGCTGGA


TGGAGAATGATTTTGACGAGCTGAGAGAAGAAGCCTTCAGACGATCAAATTACTCTGAGCTACGGGAGGACATTCAAACCAAAGGCA


AAGAAGTTGAAAACTTTGAAAAAATTTAGAAGAATGTATAACTAGAATAACCAATACAGAGAAGTGCTTAAAGGAGCTGATGGAAGC


TGAAAACCAAGGCTCGAGAACTACGTGAAGAATGCAGAAGCCTCAGGAGCCGATGCGATCAACTGGAAGAAAGGGTATCAGCAATGG


AAGATGAAATGAATGAAATGAAGCGAGAAGGGAAGTTTAGAGAAAAAAGAATAAAAAGAAATGAGCAAAGCCTCCAAGAAATATGGG


ACTATGTGAAAAGACCAAATCTACGTCTGATTGGTGTACCTGAAAGTGATGTGGAGAATGGAACCAAGTTGGAAAACACTCTGCAGG


ATATTATCCAGGAGAACTTCCCCAATCTAGCAAGGCAGGCCAACGTTCAGATTCAGGAAATACAGAGAACGCCACAAAGATACTCCT


CGAGAAGAGCAACTCCAAGACACATAATTGTCAGATTCACCAAAGTTGAAATGAAGGAAAAAATGTTAAGGGCAGCCAGAGAGAAAG


GTCGGGTTACCCTCAAAGGAAAGCCCATCAGACTAACAGCGGATCTCTCGGCAGAAACCCTACAAGCCAGAAGAGAGTGGGGGCCAA


TATTCAACATTCTTAAAGAAAAGAATTTTCAACCCAGAATTTCATATCCGGCCAAACTAAGCTTCATAAGTGAAGGAGAAATAAAAT


ACTTTATAGACAAGCAAATGCTGAGAGATTTTGTCACCACCAGCCCTGCCCTAAAAGAGCTCCTGAAGGAAGCACTAAACATGGAAA


GGAACAACCGGTACCACCCGCTGCAAAATCATGCCAAAATGTAAAGACCATCGAGACTAGGAAGAAACTGCATCAACTAATGAGCAA


AATCACCACCTAACATCATAATGACAGGATCAAATTCACACATAACAATATTAACTTTAAATATAAATGGACTAAATTCTGCAATTA


AAAGACACAGACTGGCAAGTTGGATAAAGAGTCAAGACCCATCAGTGTGCTGTATTCAGGAAACCCATCTCACGTGCAGAGACACAC


ATAGGCTCAAAATAAAAGGATGGAGGAAGATCTACCAAGCCAATGGAAAACAAAAAAAGGCAGGGGTTGCAATCCTAGTCTCTGATA


AAACAGACTTTAAACCAACAAAGATCAAAAGAGACAAAGAAGGCCATTACATAATGGTAAAGGGATCAATTCAACAAGAGGAGCTAA


CTATCCTAAATATTTATGCACCCAATACAGGAGCACCCAGATTCATAAAGCAAGTCCTGAGTGACCTACAAAGAGACTTAGACTCCC


ACACATTAATAATGGGAGACTTTAACACCCCACTGTCAACATTAGACAGATCACCGAGACAGAAAGTCAACAAGGATACCCAGGAAT


TGAACTCAGCTCTGCACCAAGCAGACCTAATAGACATCTACAGAACTCTCCACCCCAAATCAACAGAATATACATTTTTTTCAGCAC


CACACCACACCTATTCCAAAATTGACCACATAGTTGGAAGTAAAGCTCTCCTCAGCAAATGTAAAAGAACAGAAATTATAACAAACT


ATCTCTCAGACCACAGTGCAATCAAACTAGAACTCAGGATTAAGAATCTCACTCAAAGCCGCTCAACTACATGGAAACTGAACAACC


TGCTCCTGAATGACTACTGGGTACATAACGAAATGAAGGCAGAAATAAAGATGTTCTTCGAAACCAACGAGAGCAAAGACACCACAT


ACCAGAATCTCTGGGACGCATTCAAAGCAGTGTGTAGAGGGAAATTTATAGCACTAAATGCCTACAAGAGAAAGCAGGAAAGATCCA


AAATTGACACCCTAACATCACAATTAAATGAACTAGAAAAGCAAGAGCAAACACATTCAAAAGCTAGCAGAAGGCAAGAAATAACTA


AAATCAGAGCAGAACTGAAGGAAATAGAGACACAAAAAACCCTTCAAAAAATCAATGAATCCAGGAGCTGGTTTTTTGAAAGGATCA


ACAAAATTGATAGACCGCTAGCAAGACTAATAAAAAAAGAGAGAAGAATCAAATAGACACAATAAAAAATGATAAAGGGGATATCAC


CACCGATCCCACAGAAATACAAACTACCATCAGAGAATACTACAAACACCTCTACGCAAATAAACTAGAAAATCTAGAAGAAATGGA


TACATTCCTTGACACATACACTCTCCCAAGACAAAACCAGGAAGAAGTTGAATCTCTGAATAGACCAATAACAGGCTCTGAAATTGT


GGCAATAATCAATAGTTTACCAACCAAAAAGAGTCCAGGACCAGATGGATTCACAGCCGAATTCTACCAGAGGTACAAGGAGGAACT


GGTACCATTCCTTCTGAAACTATTCCAATCAATAGAAAAAGAGGGAATCCTCCCTAACTCATTTTATGAGGCCAGCATCATTCTGAT


ACCAAAGCCGGGCAGAGACACAACCAAAAAAGAGAATTTTAGACCAATATCCTTGATGAACATTGATGCAAAAATCCTCAATAAAAT


ACTGGCAAACCAAATCCAGCAGCACATCAAAAAGCTTATCCACCATGATCAAGTGGGCTTCATCCCTGGGATGCAAGGCTGGTTCAA


TATACGCAAATCAATAAATGTAATCCAGCATATAAACAGAGCCAAAGACAAAAACCACATGATTATCTCAATAGATGCAGAAAAAGC


CTTTGACAAAATTCAACAACCCTTCATGCTAAAAACTCTCAATAAATTAGGTATTGATGGGACGTATTTCAAAATATAAGAGCTATC


TATGACAAACCCACAGCCAATATCATACTGAATGGGCAAAAACTGGAAGCATTCCCTTTGAAAACTGGCACAAGACGGGGATGCCCT


CTCTCACGGCTCCTATTCAACATAGTGTTGGAAGTTCTGGCCAGGGCAATCAGGCAGGAGAAGGAAATAAAGGGTATTCAATTAGGA


AAAGAGGAAGTCAAATTGTCCCTGTTTGCAGACGACATGATTGTTTATCTAGAAAACCCCATCGTCTCAGCCCAAAATCTCCTTAAG


CTGATAAGCAACTTCAGCAAAGTCTCAGGATACAAAATCAATGTACAAAAATCACAAGCATTCTTATACACCAACAACAGACAAACA


GAGAGCCAAATCATAGGTGAACTCCCATTCACAATTACTTCAAAGAGAATAAAATACCTAGGAATCCAACTTACAAGGGATGTGAAG


GACCTCTTCAAGGAGAACTACAAACCACTGCTCAAGGAAATAAAAGAGGACACAAACAAATGGAAGAACATTCCATGCTCATGGGTA


GGAAGAATCAATATTGTGAAAATGGCCATACTGCCCAAGGTAATTTACAGATTCAATGCCATCCCCATCAAGCTACCAATGACTTTC


TTCACAGAATTGTAAAAAACTACTTTCAAGTTCATATGGAATCAAAAAAGAGCCCACATTGCCAAGTCAATCCTAAGCCAAAAGAAC


AAAGCTGGAGGCATCACACTACCTGACTTCAAACTATGCTACAAGGCTACAGTAACCAAAACAGCATGGTACTGGTACCAAAACAGA


GATATAGATCAATGGAACAGAACAGAGCCCTCAGAAATAATGCCGCATATCTACAACTATCTGATCTTTGACAAACCTGAGAAAAAC


AAGCAATGGGGAAAGGATTCCCTATTTAATAAATGGTGCTGGGAAAACTGGCTAGCCATATGTAGAAAGCTGAAACTGGATCCCTTC


CTTACACCTTATACAAAAATCAATTCAAGATGGATTAAAGATTTAAACGTTAAACCTAAAACCATAAAAACCCTAGAAGAAAACCTA


GCCATTACCATTCAGGACATAGGCGTGGGCAAGGACTTCATGTCCAAAACACCAAAAGCAATGGCAACAAAAGACAAAATTGACAAA


TCGGATCTAATTAAACTAAAGAGCTTCTGCACAGCAAAAGAAACTACCATCAGAGTGAACAGGCAACCTACAACATGGGAGAAAATT


TTCGCAACCTACTCATCTGACAAAGGGCTAATATCCAGAATCTACAATGAACTCAAACAAATTTACAAGAAAAAAACAAACAACCCC


ATCAAAAAGTGGGCGAAGGACATGAACAGACACTTCTCAAAAGAAGACATTTATGCAGCCAAAAAACACATGAAAAAATGCTCATCA


TCACTGGCCATCAGAGAAATGCAAATCAAAACCACTATGAGATATCATCTCACACCAGTTAGAATGGCAATCATTAAAAAGTCAGGA


AACAACAGGTGCTGGAGAGGATGTGGAGAAATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTCTGGAAG


TCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAATGAGTAT


AAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGCAAAGTCTTGGAACCAACCCAGATGT


CCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTGTGCAGCCATAAAAAATGATGAGTTCATATCC


TTTGTAGGGACATGGATGAAATTGGAAACCATCATTCTCAGTAAACTATCGCAAGAACAAAAAAACCAAACACCGCATATTCTCACT


CATAGGTGGGAATTGAACAATGAGATCACATGGACACAGGAAGGGGAATATCACACTCTGGGGACTGTGGTGGGGTCGGGGGAGGGG


GGAGGGATAGCATTGGGAGATATACCTAATGCTAGACGACACATTAGTGGGTGCAGCGCACCAGCATGGCACATGTATACATATGTA


ACTAACCTGCACAATGTGCACATGTACCCTAAAACTTAGAGTATAATTTTTTTTTTTTTTTTTTTCAAAAAACAGAGATCCCTTAGT


TAGGTAAACCAGGCCCTTTCTGATTGGTTGCTGTGAATCTCCTGGTTTTTTGAATACTGGCTCATTTTGAAGTTCAGTTTCATTATG


TGGCACCGAACAGGAGCGATTCCATACTGGTTCTGTCTGGTCTTTTGGGGCCTAGAGCACAGCCTCAGCCCTAAACAATGGCTTCTC


TTCCACTTTGTTTAACAGTTCTCTGAACTCTTTCAAATTAACGTTTCCGTATGGCATGAGATAAAGGTAATGGTTCATTTGTTCTCC


ATGTGGCTATCTAGTTGTTATAACACTATTTATTGAAAAGTCTATCTTTTCTTTATTGAATTACTATCATATCTTGTTAAAAATCGA


GGATATGTCTGTAGGTCAATTTCTGGATTCTCCATTCTGTTCCATTGATCTCTTGGCCATATACCACACTGTCTTGATTACTGTAGC


ATTATAATAAATCTTTAAATAAGGGAGTATAAGTCCTTCAACATTGTTCTTTTTAAAAATTCTTTTGGCTATTTTTGGTTCTTACCA


TTTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTTTTT


TGTACTAAGTCATTGAAATCTGGTGTGTTTTTACACTTACAGCACACCTTAGTCACCTTAGTCTGAATTAAGATTCAGACTAGCCAC


ATATCAAGTGTTTAGTAGCCTCATGTGGCTCATGGATACCATACTGAACAAAATAACTATAGATCAATTTGGAGATAATTGTCAAAT


AAATAGTATTTAGTATTCTTAACAAAAAATGAATTTAAAAGTGTATTATTAAGTGTCTTATTTATCTAAACAGGTATTAGTGTACAG


TTCTTGCATGTACTTTGTTAAATTTATTCCTAAGTACTTCAGGTTTTTGCGTGCTGTTATTAATGGTATTGTTTTTCATGTTTTAGT


TTTTAATTGTTCATTGCAACTTATATAAATAATTGAATTTTGCGTATTGGCCTGGTATATTCTGCAACTTATTGAAAGTGTTTACTA


GCTCTGGTATGTTATTTTGTTGACACTTTAGAACTTCCTACCTAAAAAAATATGTCTGTAAATAAAAGCAGTTTTCACTTATTAAAA


AAAAAAAAACAAAAAACAAAAAAAAGGAAAAGCATGGCAGGGCAAAGTTGCTCATTTCTATTGGGCTATGACTGGGAACCAAGAGTT


TAGGGAAGTTGGTTTCCTACTTGATGTACACACCAGTCTTTGAGGTTTACTGATTACAGGTACCCAAAGTGTGTGTTCCTGCTTGCC


TTCTCAGGTTCCTGTGTGGATGGATGGTTATCTTAATGCTGGTAATTAGGCTAAAGGAGCCATTTCACCCTTGTGGGGTCTTAGTGA


GCTGATAATAGACTAGTCTTGGAGTTCAGTTGACCTGTGTTCAGAACATGACACTGATCAGCACTGTGACCTCGGACAAGTTAATTC


ATCTCTCTCTCTCTCTTTTTTTTTTTTTTTTGAGACAGTCTCGCTCTGTCGCCCAGGCTGCAGTGCAGTGATGCAACCTCGGCTCAC


TGCAACCTCTGCCTCCCGGATTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACATGCCACCACACCTGG


CTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCAGCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCCACCT


CGGCCTCCCAAAGTGCTGGGATTACAGGAGTGAGCAACCACGCCTGGCCAATTCATCTCTTGAGCCTTAGTGTCCTCACCTGTAAGA


TGGGAATATCCACTTTACAGAGTTTTCTGGAAAATTAGATGACATGAAATAAGTGAGAGTCATAGGTGTTGTGCCTGGCACATCATA


GGCACTTGGTAAACCTGAGTTCATTTCCTTCCTTTATTCGGCAGCTTCCTGGCTCAGGTCCCTATTTCACATAAATTGTATGCCTAG


CAGCACCCTATTCATTTTATAAATTGAATATGAGAATCAGATGATAAGAGTTTGGGACCATCTTTAGCAGATGGTTTTTGTTAAAGG


TACCTTTTGAAGTGGGGGTAGTGCCGTTTCATTTCATGGTCTGTGTTGTGTACCTTTGCAGCATGTCTTTGTGATATGCAGTGATGT


CACTGGAATTTCGTACAGTAGGATGGGATACTGAAAGTAAATCTGATCATTGGTAGCACCTTTCCTGTAATTACAGCACAGGAGAGA


GGTAGTGTGACTATGTAAATAGAGCTAGAAGTGCTATTGAAATAACTCAGCAGATTCTTTAAAGAGAAAAAGGGGAGAAAAACCCCA


CCACCTTCCACAGAGACATTCCCATGCTAGGCCTGCACTGACACTGCAACACCAGATAGACGATTCAGTTTATTTTGCTCCAACATT


TTACGCGTTGGTCAGAGAAAATGGTTTTCATTAACACAAGGTAATGAAAAATTTTGTGCCATGGTATCATGTTTGTAAAAAGCTTAA


TTACATTGTTGCTGTTTCTGTTTTGAACCTAATTCTGGTAGTCTGCGCGTAGCTGGCGTGCCAGTTCCGGGTTGTGGGTCTAGGCAG


TTGGAGAAAAGAAGCAATTATCCAGTTAATGTAAAGAATCCTGCTAAGGAGGAAAGAAAGGTGCCCCTCATGCCCTCATCAGTCACT


CCAATTGGTGTTTATAGGGAATTAAGTTCTCTGGTAATTGCCCTCCTTCCCTTTCCTTTGTCTGCTAGGGCCATCATCACAGGCCTT


AAGTGAACAACTCTGGGAGTATTTCCGGCCTCTTCTCTAAGTCAGGCCAGTAATGCAGCTGTTAAGCACTGACATCTGGGTCTCAGT


CATGCTTCCAGACCAGGATTGTTCTTAGTTCCAGGAGATTAATTGACCCATAAGAAATATTATAATGCAAATATATGTTTGCGCCAA


TTTGCTGACCAGTGCTTGCTATCCTGGAATTCACAGTGTGGCAGAATACAACTGTCTGGCATTAAGGATAACCTAGGTCTTGTTTCC


ACTTGTTTCCAGCATGTACTAATCTAGGGTGAACTTTCTTCACACGTAGAGAGCATCAAAGAGGAAGGTGTTGAAGCAGGAGCCCTG


GATTAGGGATCAGGAGTGTGGAGTCTGGTTCCAACACTGTCACATTTCTGCTGTGTGTCCCTTTCCAGGCCCTTAACCTGTGCTGGG


CCTCAGTTTTCTCATGTATAGAATGCAGTAATCATAGCTTAATTTCTAGCCAGCTTTCTAGGGTTGTTAATCTATCCTTTTATCAAA


AGGATAAAATGATATGTTATAAATGAAGACACCTTAAAAAACAAAGCACTCTGCAAACGTAAGATGTTATTAAATGTAAACTCAATG


ACATTATTTCAACATTCACATTAGAGAAACAACATTTGAAGTCTTCTAGGCCACACACAAGTTATTGTAGAGCTTAAATTTCTCTTT


GGTGAAGTTCTTTTAGGACAGATAAATATGCCTCAGGGCCAGCTTATCTCTTTGAACATCGTAACTGGATATTCTTTGGCTTCCTTT


TTCCATTATTTAATCTTACTAAATTTCTCTTTTATTTTGAAGCATTGGGAATAATGAGAAAACTCGAAGATTTCAACAATAATGAGT


GGAATAATATGAAGGACCTATGGGAAGAGAGAATAAATTATATTAAATATATTCAAAGCAAAAGATGAGAAAAGACATTCTTTAAAA


AAATAGTGATAATGTTAAAATATCTTTTTTAGAAGTAATAGACTTGGGAACAGAAAAGGGATGTTGTTAACTTTTTTTTTTTTTGAA


CCGAAGTTAACACCCAGCACTGTCCTTTCTTTACTTAGCGAAACATACGGTGGAAACAGATTTCTGTGATCTTCTGCGGTCTCTGTT


ACTGGCCACCCCATTCATGTGACATCGGCACACTTGGCTCATTTAAAAGGCTTCTCAGTGATGTCTTGAAAGCCTAATCCTTTTTCA


TTTTATCTCTTTCATCCTGCAGGCCATGATGAAGTTAATTCGTTTTAACTTTCCGAGACACAACCACTTTTACAAAACAGGAAAATG


AAAGGACTCTGAAAAGTGTGACACAGAATATCTAGTTTGCAGAATAGACTGTGCAGGGCGGGAGGATGGCCGACGACGGGTTTCATT


TAGGAACTCAAAGTGAAAGGACAGGGCAAGAAGTGTAGTGAACACCTTCAGGGAAATGCCGAAGAGACCAACTGTTATTTGAAAACT


TGGATAGGTTTTGGGGCCCCAGATCCAAGCACCTTGTTTTGTTGTTGTTGTTGTTGTTGCTGTTTTTGAGACGGAGTCTTGTTCTGT


CACCAGGCTGGAGTGCAGTGGCATGATCTTGGCTCACTGCTGCCTTCGCCTCCTCAGTTCAAGCGATTCCCCTGCCCCAGCCTCCTG


AGAAGCTGGGACTACAGGCACGCACCACCATGCCCAGCTAATTTTTTTGTATTTTAGTAGAGACAGGGTTTCACCATATTGGTCAGG


ATGGTCTCAATCTCCTGACCTCGTGATCTGCCCGCCTCAGCCTCCTAAAGTGCTCGGATTACAGGCATGAGCCACTGCGCCCGGCCA


GCACCTTGGTGTTTATGGAGATGGCGATGTGCCTTGCTTCACTGGGGTATGGATGGGCGGAGTTTCTGTTCCAGACTTGCTTGTCTT


CCCCAACCCTGCCTACCTTCTTTAGAGGAGGAAATATATGTTCAGTCTTCATGGAGCTAAGAAAAAGCCAGACAGCCGAGGAAGAAG


CTAATAATTAGGCTTCTTTGGAAGGTATGAGACAAATTGGCAGCATGGTCACCCGGGAAAACACAGTGGGGCTTTGTCTGCAACTAA


GAACTCTAGAAATCATGGTGTCTGGATACCACGGGGTTAAAGCTGTGGAAGCCTCAGCCTGCGTGTGGAAGCTGGGCTTTCTAATTG


GATCACTGGCACACACAGTGCTGTTGCTTCTTCTCTGCCCATGTCCCCCAGAGCATCTATCTGCTTTTGTTACTGCATTGTTATGAA


TGCCCTTCTTTGGCGCCCTCCACTTTTCCTGAAGGCAGGCTGGGAAGCAGCCCTTGGCATGTGTGATGGCTGCGCTGCATGCTGGCC


ATCGAAGGATGTCCATCCAAGGAAAAGCTGCTCTCCCTCAGCCCTCACCCTTGGCTTTTGCCCCACCCTGCCTCCCAACTGCCGGTG


CATTCAATTCCCTGCCTTTGTCCAAGGGGCAGGACAGGGCACGACCACTTTGGCTCCCCTTTTCCCTTTGGAAGCCAAAGTCACTCC


TCCAGCTTCAGAACTGTGAGTTTCTTGTGCATGCCGCTGGCTTGGTGGGAATATGAGAATGCGAACTCTAACTCTCACTGTGTGAAG


AGTTGGCAAGGGTGCATGTGCACGCTATTGTGTGTTATCTGTAAGAGAACTGCAAAAACAAGTGTCTAGAATTAGATTCAGTGCTTC


AGGACCCCCTCTCCTTTCTCCATTTAGATTCCTCAACAGAAGCTGCTTTTCGCTTGATTAACTGTAACAAACTCTCTTTGGAGTTTT


GTATTTTGGAAACTGCATTGCCAAAGGAAAATCATTATGTCTGCTGTAAAAGCCCCAAATAAATTCCTCCTAGGGTAAATGGAGGAA


AAAGAATAGAAGGGTTTAATCTATCATCTTGCCTATTAGTGAAATACTTAGTGACCTAGTTCATTTACATATTAAATGTGCTAGACC


TATTTGTGCCTTCTTTTTTTTTAACTTGTTACCCCGGAAACCATGCCCTGGCTCAGAAATTACACAAGGCCAACAGCAAATCTGCAG


TCTGGTTTCTTCACACAGACAAGTCAGTTAATGGGGAAAGGTTAGATTGTCCCAAAATGTCTTCAGTCGTTAGTAGAAAAAGGAGAG


GAAGGAGAAAAAGTGAGAAACATGTATTATTTTGGTAACATTTTCAAAATACTACTTTTAAACTAATTGGAAGGGATTTTACCTAGA


CTTAAGAAGAAAATAATAGTGTGGACTCTTAAAACTTCAGTCTGCTTTTAAAGAACTTTCCTGGTACATTTGGCAGCACTGGCATGA


AAAGGATCAGCTATCAATTGACATTGAATTCCAGACCTACATTTAAGGAATCTTGACTCTCTCATTGCTTTGTTGTAATAGCACTGG


TTCTTCCAGATTGTTTGGTGGTGTCTTATGTTCTCAGGCCAACTTTTCAAGAGTCTGAGAAGCAGAATTTAAAAATACGATTTAGTT


AGCAGCTAGAGAGCAAAATTTCAGCCCATCTTCCCACCTGAATATGTAGCCTGCAAGTTCTGGGAGAACAAGGAACTTTACTGATCT


TCTACAGTGTCTCATTTCACAGTGGAGGAGATTGGCACCCAGAGAGGTGAAATAAATTGCCAAGGGCATCCATCTGGTTTGGGGCAG


TCTAGACTAGAAAACAGGCTTCTTAACACATCTTGCAGCATCATGGATGGAACTGGAGGCTATTATCCTAAGTGAAATAACTCAGAA


ACAGAAAGTAAAATACTACATGTTCCCACTTACAAGTGGAAGCTAAACAATGGATACACATGGACATAGAGAGTGGAATAATAGGCT


GGGCGCAGTGGCTCACGCCTTTAATCTCAGCACTTTGGGAGGCTGAGGCAGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCT


TGCCAACATGCTGAAAACCTATCTCTACTGAAAATACAAAAAATGGCCAGGTGTGGCGGTGCATGCCTGTAATCCTAGCTACTTGGG


AGGCTGAGGCAGGAGAATTGTTTGAACCCCGGAGGCAGAGGTCGCAGTAAGCCAAGATTGCGCCACTGCACTCCAGTCTGTGTGACA


GAGCAAGACTGCCTCAAAAAAAAAAGAGAGAGAGTGGAATAATAGACATTGGAGACTACCAAAGGTGGGAGGCTGAACGTTGAAGTA


TTGCTTGTTTGTTACAGTGTTCACCATTCGGGTAATGGGTACACTACAAGCCTAGAGTTTGTTGCTATGCAATATATGCACACCAGA


AAATATGCACTTGTACCCCCTAAATGTATAAGAATTTTCAAAAAACTTTTTAAAAATTAGGTTTTTTGACTGCAGATCTAGTGCTCT


TTCAACATTAGTCCTGACACAGATAAGTCACTTGCTTTGAGTTCTGTCAGAGGTAAAGCTGGGTGAAGAAATTGTGAGAAGAATGCT


ATTCTCTTTAAGCCAGCCACCAGCCAGCTTACTTGGGAAGCGGTGGAAGGAGGACACAGTGTATCCTCAAATGTTAAATCCCTTCTT


AGTGGTATTTGTTGTGGATAGAGGAATTAGATTGAATGTGGAACTTTGAGCACTCTGAGGATAAATTGTGCCTTCTCATTCAAGAAC


ACATTCAATTCTCTTGGTCACTCCATCTTTTCTGAAGTTCCTTTTACCATGCTTTGCAGTGGCGATAGGCCTATTGCATGAAGAGAT


AAAATGTCTTTTAGGCTTTTTCCTCTTAAAAACTTGGGATAAGAACAAGTTAGCCTGAGGCAATCACAGAGTCTTTATAAAGAGACT


TTTAGCAAGGAAATGATTTTTCAAATACAGTACAGGATTTTGGGCATGACTTTGAACTGGAAAGTCTACATATATAAGTAGAAGATG


GTGTGTAATATCTTTGCAAATACTTTTGTGTATTCATTCCTCATTTGTAAATGTTTTCTTACCTGCTGACTCAAGCACTGACAGTGT


ATTTGTTTGCTCATTCAACTATGGACTGTGAACATGCTTGGGAAACAGAGTTGAGTATTGTACGCAATCTCTGACCTCAGTAATACT


TAGGCATATATGCTTATTCAGTAACTGGACATTTTAAAATAAAAAGAAATGAGTATTTTCACTGCTTGCATATAATGGGAATGATTG


AATAACTTTCCCATAAGATGGCATTAGTTCAAGTGTCCTTATTTTAGTAAGAGTATTTCAGGCCAGGTGTGGTGGCACACACCTGTA


GTCCCAGCTACTCAGGAGGCAGAGGCAGGAGGATCCTTTGAGCCCAGGAGCTAGACTCCAGCCTGGGTAACAAAGAAAGACCGCATC


TCTTTGAAAAAATAATTTGGAAGCTCTCCGTAAAAATCTCACCTCTTATTTTCCTCAAAACAAGCTCTGGTGCATTAGGGTATATAG


TAGGGTCCCCTGGCCTTTGGAATGGGGGGTTATTTGAGACTGGAAGGTGGGAGTGGGAGAGGGAGGGGGAGCCAGGGACAAGCATGG


CAAAGTTCCAGATTCTCTGTATTTGTGTGAAAAATCACAAAACCCTACATTGACTGTGTAGTGGATGTCAGATGGGAAGAGGGAGTG


GGGAAGCAATGAATAATAGCAATCACAGGTGCAGGAGCCACGTCTCCTCCTGGGCACTTTACATGCGTTCTCTCACTTATTCTTCTT


TCTCACCCTGTGAGGCTTGGTCCAGTTGCTATTCCCAAATCACCCATGAGGAACCTGATGCTGTGAAGATCAGCAGCATGGCCAAGG


CCGTGTAGTGAAGTGATGAGCAGGAGTTAGTCCCGGTCTTTCTGTTGTCTGAGCTTACCAGCTCTTGCCTTCACACAGTGCTCTCTC


CTCTCTTATCAAGTTGAACGTGGGTCAGGACCATGAAGTTAATTTTCTTCCTCCTTTTAATCATCAAAATGGAATTTCTGTTTTGCC


TGTTAGAGATTATTGATATAAGAAAGGCTGGGCGTTAAATGCTGAGAACACATGGACACATAGAGGGGAACAATCACACCCTGGGGC


CTGGTGGAGGGTGGAGGGTGGGAGGAGGGAGGGGATTAAGAAACAACGAATGGGTACTAGGCTGAATACCTGAGTGATTAAACAGTC


TGTACAACAGACCTCCATGACACAAGTTTACCTGTGTAACAAACCTGCATTTTAAAAGTTAAAAAAATGAAAGGCTTTATATCAATA


AATAAGTGGGCCTAAAAAAGGGAGACAAAATGAAGGAAAATTATTCTGGATTCTTAAGAATAAAAGTGAAAATATCGGACTAAACTG


ATAAAATGAGGTAGAAAATAGAGGAATCACATACACAGTTTTGACTTCCAACCCACTTTGCCTTAAGTTATTTCAGTTGACAAGTCG


AAGTTGGGTTGAGGGGATGAGGGTAGGAGGTGAGTGATGTATGGATAAATACAACGTTCTATTTTCTAATGGTAAGTATATCTGCCT


TCCCTCCCTCCAGTGCTTTTATACGGTACCAAGGAATATGTTTTGCTTTTTGTCTTGACAAGGGAATTCACAACTCATAACAGCTAT


TTGACATCTTTTGTGGGTACCAAGCTCACTTTTCTTCTTTCCAGTGATAAGTGCCTTAATAGAACAAAGTCAACATAATCCTTGCCT


CCAGGGAGCTTGCAGTTTAATGAGGGGGGCACATGTTTACAATATAGTGGGGTCAGTGCTGGGGAGGCATTGAGGAAGAACTTAGTG


TATGAATCCATCTCCGAACTTCAGTGATGTGGAAAATAAGCTGTTAGAAAGATATCTTGGACTTCATTTTTCAAGCAGCTTGAACTC


CTCAAACAATTGTTCTGCAGACTTATTTGCCACGAGATTTGTGACTTGAAGTCTAGTGTTTAGATCACAGTGAGCTTTTTGGAGATG


AGATTTGTGCTCACATCTGTGGCAAGTCAACGTGTGGCAAATGCCTGTTTTGACTGTCAAAACGGAAAGCAAATCTCTTTGCGTGAT


TTTCTATGTCATTTTCTTTATTAGTGCACATGTCATGGGCGTTTCTTTTCCTTGGCGTTTTGTGTGAACTTAATCCTAGACAGAACC


TCAGTTTGAGTGGTTAAGGCTCAGCATCCTGGTCAGCGTCTGAGCTGCTGTCCTCTGGGTCCCTGTTGTGCCGTCAGCTCCAGTGGG


GATGGCACCAGGTTCAGGAGGCTGAAGAAGTGACCCAGAGCCAGCAAACGCAACATGCGGTTGCGTCGGGGGCTTACATACAGGGGA


GAGGGCCCAGCGGCTATGCGCTGGACAAGAGAACCGCAATCACTTGCAAAAGCTATGCAGTTTATATTGCATTTTCACTTAGTACTC


TGTTTAACGATTCCACCTGGCAACCTTCATTCATGCCAAAACTCGGGGCCTCCATTTCCCTACAGCCCATGTCCCACAAGAGATGGG


CCGGGAGCTCAGATGTTCCTCATAGACAAGGAACAGATCTCTGGGGTGGCCACTTCCAGATCCCTAGCTCAGAACTCTGAACACATT


CGGGGCATCTGCCATACAGAATCATTCTTAAGAGTACGCTTAAGTTACTGCTATCAGGTGCATTTACTGTATACCCCTAAAGTGACT


TCAACTTCTAGTCAGTCTAATGAAATTTGATTTCATGCAGAGGGTCTCTTAGACAAAAATTACATCTATAAGCAAATTACTGGCTGC


GCAGGTTACTTTGAAATATTTCTGGTGTTTTTTTAAAAAAATCAGTTAAGCTGATCAGAGACAAAGCGAAGAAATTACCCTTTTCTT


TTTAATGTGCAGCAAAATGTGTACTAATGGTGCAATCACAGAATATTAGGTTGTTAATACAATCAATAAAAAGTTAATCCGTTTTGG


ATTTCATTGTATTATGTTTTTCTTGTTTGTGGAATAACGTAATTGTGACAGAGTAATTAATACCCTGCAGAGGGATTAGCCGTCAAG


ATTGAGATAAAAGAACAAGGAGACAAGAGCAGAGTTGCCTAGAAGACAGGGGCGTTTAGAAAGTGCTGAGGCATAGAGTTTCCTTAA


GGTGATTTTTTACCTTTCCTGACTCTAATTATACATTTTTGCATCTAGTAGTGATACAGCTGGGTTGGTAAAACATATTATTAATAG


AAGTGAGGGAGTTCTGAGGTGGATCAGATTTTTCCCTTTAAGCTTGGTTTCCAGCCAAGCCACCGGTCCTCAATTGGTATTTTGCTG


TGTGTTCAGAATGGCTTTTTCACTTCTGTAATTTACTTATTTCTTATTATTTGTTATTCAAAGATCTTTTGGTCATTTATTCTGCAC


AAATCCTAGAAAATGAAAGCCAAATAAGGAGGGATTCCCCCAAATGACTACTAGTTTTTATATCAGTGCATGGTGGGCCTCTCAGTG


CCAACAGATTGTTCCCGTTAATTTTTTTTTCCCCTTTATATTGACTCTGGGGTTTCTAATGGTCAGCCTGTGCTTTCAGATTGGAGT


TATTAACTTTGACCAAAACAGGAGTGGTTTGAGAAGAGGCAGTAGAGAGGAGAAAGTGGAGATCTAGCCAGAATCTTTTGTTTTCCA


CAGAAATTAGAGAGGGAAAAGACTATAGGAATCAGACTCTGTCAGCCTTGTCCTTTGTAGCCCCTACCCAGGCAGCAAAGAGGAAAC


TGTCTTCTTCCTGTACGGGTCTCCAATTGGCTGACATTATAAATAGTCTCAGTGGCAGGTTTCTCATTTTTGAATAAAAAAACACGC


TTTCATGCTAAATTATTAAACATTCTGTGGTTTGGCTTTAAAATCAAATAAATAACTCTCTTTATGAATGCATTAGACACCCTCCCT


AGTTTCCTTTTAATTGTTTGTTCTCCCCTGTTCCTCATCTTGGACTTCAAGGCCATCATCTTGGTATTCTGGTGTCTGCTCTTCTCT


TGCTGACTTCTCTCTGGGAAACCTTTTCCAGGTCGGCTTGTTCCACTATCACCCACCTCCCTGTGAAGGAAGATTGAAGCTGGTGTA


GATGGGGCTTCCTGCCTGCCCTGGAAGTCTGAGCCAAGAGTAATTTTACCCTCATCTTTCCACAGTGTGTATAAGAGTAAAAAAGGT


CAGCTGGACACTTGCCTCGCTGGGATAGAGCAGTCAGAGTCAGATGATGTTTCTATGAACTGTTTTGTTTGGGGTCAGATGGACTCA


ACTGTGCAGTCCACATCATCTGCCCCCATCTGCACTGACCTGATATGGTGGGTGGCCACATCCTAAAATAGTTTCTCAGAGACTTTG


TGTGTGAAACATACATATAAATGTGTTCATGTTTATAATGTTGGTGTGCAAGAGTTTATTTTGCTTAAAGAAGATAATGGAAATTTT


GGTTTCAACTAACATATCTATTTTCTCTCCACTAATGAGTATGGAAGGTTTTCTCCTAGATGAAAACATGGAGAGAATCACTAATAA


GAAGAGAAAGCTGTTGAGTACTGTTAAAATATCACAAAACAGTTACTATTATAGTCATATATATGATACGTTCATTCTTTTAGAGGA


TAATTTAAACATTATTTTGGGTATATAGGGTTTTAAAAAATCTATTCAGCATCTAATATGAATGTGTGAAAAATTTCACATAAATTT


TCATATAGTAATTGGGACCAAATTATTTGCTGTCTTTTGTCTCTTTCACATTGTTTATGAAGATCTGGCTTGAATAAAGGAGTCAGG


AGCTTTCGCCTTCCATAGCTAAGCCCAACTGTCCTAATGCTGCATAAGACAGCTGGGATTAGAGAAACTCTTGAAAAGCAGGATTGG


TAATGGGAAGTGATAGCTGTGTGTGAAAGCCTTAATGCTGAAGTGCATTCTTGTAACGCAATTTTCTTGTCTGCCTTGTTATCTTAC


AATTTTAGTGGGAAAAATAATAACAATGTTATTTCAAAGAAATGGTTAAAAAATAGTCAAACTTAATAGAAAGCAGAGCCCTGTCCT


TTGGTTAAACACTCATTTACTCAGCTCTCTCTCTCTTTTTAAAAAACAGAACCATGAATCCTTCCTGTACAGTTGCATGGGTTGATA


TTAACTCTCTCTCAGCTTATTCACTGTCCACCTAAAAGAATAGTACAGGGCTCCAGAAATGTACCTTGCTCTGGTTTATAGGTAAAA


TGCTGCACTTGGGCATAGGTTTGTGGAGGGTGAGTATTGTTTCTCTTCCTGTGATGAAGATTGATGGCATTCCTGATAAAGGAAGAA


GAGCGTGTTTGAGGATGCTGGAAGATGCTGAAGTGAAGCTGAGAACGTGACGGCCAGCCTGGGCTCTTGGGGGTGGAGGATGGTTGT


GGATGCTGTGTTGCAGTTGACTATGCCCTTTCTGGAGGTGTACGGGTAGCACCTGTTCTGCTCTAACAGCTTTGTGGGGAGGACAGC


CACCCACCAGAGCCCCCCATCCAGCACGTCTTCCTATTTCCTTGGTATTAGTAACTACATGGGGGATATTTATCTATGTTTTAATGC


ACACAGGCTAGTGCAGTCAAGGGTGTGGGGCATACAAAGGTAAAAAATAGATCATTGTTACCCTATAGAAGCTTTCAGTTGGCATGT


GTAGTGGGAGGTGTGCTTTAGGGAGGTGTCATATGTAACTTAGAGGAAAGAATTCCCAAGGTGGCTGAGAGGACTGGGGAGGTGGGA


GAGTCTGCTTTGGATCTGGAGGAAAAGTGGCACTGTCTACCTAAGAGAATAGTGCCAAAGACAATTTGCACAGAGTTTGGCATATAA


TAAGTACTAATAGGCTAGGCACAGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCAGATCACTCGAGGTCAG


GAGTTTGAGAACAGCCTGGCCAATATGGCAAAACCCCATCTTTACTACAAATACAAAAATTAGCTGGGCGTGGTGGTGTGTGCCTGT


AATCCCAGGGGTAGCTGAGACAGCAGAATCTCTTGAACCCAGGAGACGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAG


CCTGGGCGACAGAGCAAGACTCTGTCTCAAAAAAATAAAATAAATACTAATAAATACTTAATGAAAGAAGGAGAAAAGTCTAGGGAA


GTTATTATTTGGGGAAGAGCTAAGAGGAATTCATCTGTGAATAGACAAACTGAATATCATTCCACGATTACTTTCACTTTAAATGTA


AGTATTTAAGGGTACCGTGAATGAATTCCTTCACAGATGTGTTGGCTCTGCAGGGATAAAGGTGATGGGGTTTCCAGTTCATGTTGC


AAGTTCATGTCTCAAGGGGAGGTTCTGTGAGACTTGGGCTGTGTCCTGACCACACAGCTTTGCATAATTGATTAATTCTGCATAACT


GCTTGCATTCCTTTCCTAAAATAACTTTCACTTTCTAATTAGCTCTCCAGAATTAATAAGTGCCAAAAAATAGGATGTGTGTTGAAT


CTTGTGATCTAATGTGATGCTGCCAACTCACACAGATTTAAGGTATAATTAATAATGCTGAATCTCTGAGGGAATTCTTAATTCCTG


AATTGGTAGACAGATCTCTAAAAAGTAGCTAATACTTATTGTGTTTACCATGTGCCGGGCACTGTGCTGAGGACTTTACCCAGTTTA


CCTCCTTGATCTGTTTTCATTATCACAAACACCCTAAGGATTAGTATTATGGGTATCTCCATTTCTAGAGAGGTAAAGTCACTCACA


CAGCCAATTGACACAGCCAGTGAATAGCAGAACTGGATTTGGCCTGAAAGACTCAGGCTCTGGAGCCAGTGCTCCTAAAGGCCATGT


GACATTGCTTCTCTTTTCTTTCTCTGGGGTGTTCCAGTTTTCCTCAGGGCTTCGTCATTGCTGCTTTCTACTTGCTGACACTTTTGT


CAAATGTGATAAACAGCAAAAATTGATACAGTACAGGTCCAAAATAAACGGACCCTGATAGGTACCACAGGTAAAGTTGTTGGCAAA


TGACATCACTTATGTAATGGTAGGTCCTTCACTGGAGGTCAATTATGGAGCGATGCTGTGAGGGAAAGGTAGGTAGATGTCTCTGGG


CTGGGAGAAGGCAAATGATGAGGGGACTTGGAGTTTCAGGGGGGGAAACAATAAAGATTCTGGTTGGCAAGTTTCTTGGCAAATTTT


AAGGGTGGTAAACATTTTAAATCAGTATGTCAGTAACTTCTGCATGAGAAGTGCCAGGTACTTCACAAAACTTTAATATAATGTGTG


AGCCTTAGGGTTGAAAGTAGGGATGGCACTGCTTCTGGCTTCTCTGTTAACAGAAATATGAGAGAGAAGTATGAATAATTTTTTCTC


AAATTGAGTTTTAGATTGGGGTTTCATTTTTCAGCAGAATATAAAACAGTTATTTTCTATTTCCATGAATACCAGGAGGGGAGACTT


AATAAAATGCAGTAAATATGGCCGGGTGCAGTGGCTCACACCTGCAATCCCAGCACTTTGGGAGGCCGAGGTGGGCAGATCACCTGA


GGTCAGGAGTTCAAGATCAGCCTGGTCAACATGGCAAAACCCCATTTCTACTAAAAATACAAAAAATTAGCCAGATGTGGTGGCGGG


TACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACACGGGAGGTGGAGGTTGCAGTGAGCTGAGATCGCAC


CACTGCATTCCAGCCTGGGCGACAGAGCAAGACACTGTCTCAACACAAACAAACAGAATAAAGTAATAAATAGGTGTATGCTGAAAG


AAAAATCATTCTTAGTCCTGGCCTTTTTTTGAGACAGGGTCTTGCTTTGTTGCCTAGGTATCATCACAGCTCACTGCAGCCTGGACT


TCCTGGGCCCAAGTGACCCTCCATCCTCAGTTTTCCAAGTAGCTGGGACTATAGGCACATGCCACCACGCCTGGCTAATTTTTTAGT


TTTTTGCCCAAGCTGGTCTCGAACTTCTGACCTCAAGCAATCCTCCCATCTCGACCTCCCAAAGTATGTTGTCTGGGATTACAGGTG


TGAGCCACTGCTCATGGCCCCATGACATTTTTTAAATCAAAATATCTAGATAAAAATCAACATATTCAGACAATCTAATTTGGTTGA


TATACAACTATGTTTTTAAAAATTTTCCCTTTTTGAAAAAGGCAATATTTGTGGTGATTGTAGACTTAGCAATGTAAGTTTAAGTTT


TGTAACATTGCAGGTTGATTTTGAGTTAATTGAAACATTTGAAGTTTAATATGTTGGCAAAGTGGATTGTGTACATGAATTGAGGGG


GAAAGAGGAAATTAATACTGTTTGATTTTTTTTTTAATTTTCTTGTAAATAATGTGAATATCCAGAAAGCAACAGAATAACCTAAGT


TATCAGAGGCTGAGAAAGGACATAAAATAACCTTTATTATTATTATTGTTTTTTTAGATGGAGTCTCGCTCTGTCCACCAGGCTGGA


GTGCAGTGGTGCCATCTCAGCTTACTGCAATCTGTGCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGAT


TACAGGCATGCACCACCACACCCAGCTATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGATGGTCTCGATCTC


CTGACCTTGTGATCTGCCTGTCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCCAGCCACTTTTTTTTTTTTT


TTGTGGGGTGGGGGGCGCAGATGGATGGGAATGGCATTGAATACAATATTCAGGATATTGTAGATGAAAGAGGAAAAGTTTCTAGAA


TATTATGTGACTGTTGTGGGAGGTGTTGAATATTATAAATAAGGAGATTTTGCTGCTGTTGTTTTTGTTTCTGAGGAAAAGAAACCC


TTGGATTAGCCCCAGTGGTTCTGGCTGGTGAAATTACCCAGTAAATAACCACAGACGTCTCGTTAGCAGAAAGAGAGAAGGGAATCA


GCAGAAAGAGCTGGGGAACAAGGTTCACTGGGGGCTTTCAAACTTCTCAGGTAGTATGTGTATTGAAGAGCTTAGATCTGAAAGATT


ACTATGTGCTCAAATACTTTTGTGAAAAATTCAGAAAGCCTATGTATAAATCTGAGAGAGAATGTGTGTGTGAGTAGCGATTATCTC


TGATGACTTACATATTTTAAATAATTTTCTATATTTTTTGTTTTCCAGATATTTGTATATATGGATCCATTTTGTTCATGTTGAGTT


TGTACTTTATTTTTAAAAATTTGCCACTACATTGTAAGCTTTCCCTGTGTCATGAGGTGTTCCTTGCAGAGGGGATTCACAACACTC


TGTTTCCTTCTCCACTCAGCGTGCTGGCTCTGGCTCTGGCTCTGGCCCTTGTCTGCACCTCTCAGCTCCTACACTCCGGAGTCTGTG


CTTTTCCTGTGGCCCAGAACATTCCAGCTGCCACCCTCTTCACCTGGCTAGCTCTTAATCTTCGTGGTGCCCTTTTCTTTTTTAGGA


GGACTTAAATGCATTGGACAGTGGACAAAGACCATTTAAATGGATTACAAAAAGCAGACTTCACCAGGCAGACCGGCCTCTAACTTC


TTCAGTAATGTTGCCATTTACCATGTGTCTGTTGGGGATCAGGTCCGTCGCTAGGCACCCTTCGTGCTTTTAGGTAATAGTCATAGC


TACCCTGAATAAGGGTGAGGAGATGGCATTCCCATTTAGAAGTTGAAACCAGGATTGCAAGAAGTGTATGAGCCGGGATGGGAAAAG


CCAGGTCTGTCTCTCTGCCCTTAGATCACGCTGCTGTTACTATTCTTTGTGACACCCTAGGACATTGCCGTGGAAGGAAGGGGAGAA


ACCTTGATAGGGCCCTTGGATGAAGCACTGCAGCTTATGCTAAGAAGATCAAGGCCCTGTTAGACTGGAAACATTCATTGTAAGACC


TAGTGCCATAAGGTAAAGAGGTCTCTAGGAGAATGCTCAAGATCTCTGAGGGATAACTGTTAAATATCCTGTAAGAATTAGGCTTAA


ATTATACACACGTGAGAAAGGTAAGTGCTCTCAGTGCAGGGGGTAAAATAAACCTTTAGTGAAACTCTATGACGAGGAACCCTGCCC


ATCAACTGTTGGTAAGTTTAGAAAAAATGAAGAGATGCAATTCAAGGTCAGTAAGTAGGTGAAATATGATGTGCGCATAAACCTTTA


AAGGTTTGAGAGGTTGGCTGTTTTTGGTAACGGGTTAACTTGAGGATTAATGAGTCAGGATATATGGAAAGTTAAAATTCCCTTCTC


TGCACCATTCAATTCAGTTCAACAAATACTTTCCCAGGCCAAATGGGATCATTAGCCTTGTAGGAAACTCTTGGCCTTTTTAAAATG


ATGACATTGTGGCCAGTTTTGTAAATACAGTTGATGCGTGAATCTGTAGACCAAGGATCAGATTAATTTTGTAATGCCCTCAGGGAA


GGCAGTTGATGAACTGGTTTCTCTGCATCATAAGAGCAGTGTTAATGATCCACTTGTACCATGAGATTCTAACATTCCTGAGTTACC


TAAATGCTTCAGTGTTCCCTGCCATGTAATTTTAAGCTGTATGTACATTTTTGGGATAATTTTTATCCATATTTTGTTTAAAAAATG


AACTAAACCAAACTAAAATTCAGAACATTTTGTACTTCTGCTTCTTATTAAGATTGTTTAGTCCTTGGTGGGTGATGTGAGAAGATC


AGTACTTAACAGTTTGAGAATTCTTGCTCTCATAAATCAAAATAGTATTCGATGACAGTTTTCAAACAGTTTCAAGTGATGATTTAG


ATTCTCTTGTAGTTGTTATCTACTTTAGAATAGTGTTACTATGATTTAAAAGTTGGTATTTCGGCTGGGCCATGGTGGCTCAAGCCT


GTAATCCTAAAACTTTGGGAGGCCAAGATGGGAGGATCACTTGAGCGCAGGAGTTCGAGACCAGCCTGGGCAACATAGACTCTATCT


GTACAAAATACAAAATTTAAAAAGTTGTTATTTCATGAGTTTGCATTTTTAAATGCAATGGACAATAGATAGAACTGTTTATAAGAT


ATATTTGCTTGTATGTTTTTCTCTTCATATTACGAGGTCAAACCACAGAGGAAAAATAAAATTTGGAGGCCCTAACCCTATTTACCC


AATGTCTCCTAGAAGAGCCCCCTTCAGAAACTTCTAGCAATTGTTAGTGTTGCTTGGGTTAATAGCCATGGTCAAAGCATGAACAGA


ACAAAATAAAAATTTTCTAAATATAAGGAAATATGGTAATAACTGAGAAGCCAAGCATTAATAACTGGGAAGCCAAAGCATTCTCTC


AATATCCTCTTTCTCCATAAGAAACGTGTAGCATTTTCCTTGGAGAAGGGTCTATGTTACTTTTGTTCAGCCCTTGATGAAAACAAC


ATATGGTTAGTTTTATGAGGACTTAGAGACAGATGGTGACCTACAGGCTAATTATGCAGTGGGCAAGATTCTTTAAACAAATCACTG


TGATTGTGACATGGCCCTTTCTCATGAGTTAGACAATCTGGACTGTTCATTGTCACACTAGGTAAACATGTTCCAGGTGAATGAGGA


AGAGGTGCTACGTGAGGGAAATGTATTTACAACATCTTTTCATCTCCATATTTACTTTAATGGGTATAAGAGAAAAGGAAGTCAAGA


AGGTAAAAGGGGAGCACACTAAAACCTCAGCTAGTGCTAGGATTGTGTTATTTTGGACAGCTAACTTTTCAGATAGCTGAGGGGTTC


CCCCATTAAGCATAAACGTTTTTCTTTTAATCACTTTGAATGAACTCTTTCTGAAGTCTTCCTTGCCCTCTGAAAACAGAATGTCTG


AGACGTAGTAGGCTTTATAGTGTTTATGATCTTACTTTTCCTGCTTTCCCAAACGTAAGCTTCATGAAGGTAGCGGTCTCAGTCTGT


TCTGTGCTGTGACCCTGGCCCCTAGAACAGTGCTGGTACACAGCCACATTAAATATTTGCTGAAGTAAGTGGGAATTAATTAAAGCT


CTTTAATCTTCACAACTGTGTCACTGTCCAGGCTTTGTTCTCCCTGTTTGTAGATTGGTCAGGGACCCTAGAGTGCATTGTGCCTAT


GCTTACGGTCTTAATGTCCCTCTGCCCCAGTGTGGTGGCTCATGGCTGTAATCCCAGCACTTTTGGAGGCCAAGACCAGCGGATCAC


TTGAGATCAGGAGTTCGAGACTAGCCTGGAAAAAATTGTTAACGGCGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGTG


TGGTGGTAATCGCAGCTACTTGGGAGGCTGAGGCATGAGAATCACTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCAGGATCCCAC


CACTGTACTCCAGCCTGGGTGACAGAGTTGAGACTGTGTCTCTAAATAAATAAATAAATAAATAAATAAAATGTCTCTCTCATTATA


TTGTAATTGCCTTTTCTTGTCTCTCTCCACCACCGGACTGTAATATCATTGACAGCAGAAATTTTGGAGGTTCACTGTTATATCCAC


AATGTCTGGTAGTACATATTGTTACTTGTTTCTTGAACGTGTGAACAAACTAATTCACCAAAGGAAATGGTCACTGCCCTGGGTCCT


TTCCTTTACAAAATCGTATGATGTAGATAGTTTGATGCCCATTTTACATACACACAGCTGAGAGGAGCAGCCGTGATTTGCATCCAG


GTTTGTCAGCCTCAAGGCTAACCTTCCACCGTATGGGTAGCTCCTCACCTTTACACACACAAGTGCCCCCTTTCTGATGTCAAATTT


TCCTAACCTTGCACAGTATGTGGTTTTTTTTTACTTACCTCACCCAGAATGGTATAATAAAAATGCTGTTATCAGTTTAGTAGTGCT


TTTAGTTACTGTTTTTAGTCATTATACTAACATTGTAAATTTGAAAAAAAAAAAAAAAAGCCAGAACGGTTTGTGGGAGAACTTCTT


GTTGGTTGCAATGCTCCAGGCTGCCTGGGGTTTGCCAGCCACCCCCCTGCAGTAACCCTGTGCACTTCCCCTTTCCCCAGACTCCCT


CCTCCCCGCCAGCAGCCCCTTCTGCGCTCCCCCGTGCAGCCTGCCCTCCATGAGTGGCCACGGACTTCAGGGTCCACGCGGTTCTTC


ACACCGCCCTTTATGTGATGTGTGTCCCCTCCTTGGCTGTCTGGTTTTGCTTTTGTCAGTAGGGCTAGTGGCCAGCCCATCTCCATT


TTGAATTTGCTGTTTTATAATAAGCCTTTGATTTGAAAGCCAGATGATCAGGGCTGCTAGAACTTGCTAGAATGAGGAAAATAGACA


AGTGGTCCATTGACCTCTGAGTGAGTTACAGTAACTTTTACTACATGGATTTCTTTTTTTTTTTGAGATAGAGTCTTGCTCTGTCGC


CCATATTGGAGCGTAGTGGCGCGATCTCGGCTCGCTGCAACCTCCACCTCTCAGGCACCCTGAGAGGCCCTGTTCTCAGGCCTTCTC


AGGGTACTGGTAGGTGAGGCCCCAGCACGCGTTGCTCAGAGCCAGTTTGGCTCAGGTCTGTAGGAGGTGCGATGTGGACATAAGTGG


GGTGGAGTATGAAAGAGGAGAGATGGCAAAATGGGAGAGCGTTTACCTGGTCAAGGGCTTAGGTCACATTAGGTTCTCAAAGGCAAA


TATGGCTTCATGTGGATACTTTCTTGAGTCCATCTCTCTCTGTTTCTGTTCCTCCCTCTGCCTAACCTATCCTGGCTCTAAGCTGGC


TCAGACACTGCGTTTGTGTCTTTTCACGTGGCATTTTTCTTTTTTCCCTCCACCTTGCTAAGTGCTGAAATTTGCAGTCAGCATTTA


TATATGCCCTATAGACAAGGCACATTTCTCTAGTTTTACCTTTCTTGTCATTTGTGATCTTTTAAATTTTCAGTCAATGGAAAGTAA


TTGTTAATATGAATTGCAGTTTGGAAACTTTGTGCCAGATGATGAAACTGAATGAATCTGTGGTCTTTACGTAGGCAGTGCCTTACG


TATGGTTTGGTTTTTGGCCCATGTACTAGATGTTTGCCTTTCTGTGGGCTGTCACAGATCTGGCATGTACCTTTATTTTTTTGGGAG


TTTCTACATGTGTTGCTGCAATCTCTCAGCTAAGAGTATTTTTCAGTCCTCTTGCTATTTGTTTTTTACCACTTATAGGGTGAAAGG


AAGTAAAATTAGATAGGATTTTGATGTTTGATTTAAAAATCAACATTTCCATGAATTCAAAACTTCAAGAAGATGAAAGGATAACAT


TGATTCTTCTGTTTAAAGAAAATTGATTTCCTTTGGCTGAAAAAGTTTTGTTCTCTCTCTCTTGGTGTTCATTATTTTAGATGTTCC


CTTTGGACTCTGTGCACATCCCCATCATAGAACCTACTATATTTACTATGATAGTAAATTGACCTCTCTGCCAACACCACTGGACCA


TGTAAGTTCCTTGAAGGCAGGGGTCCCTAGTGACAGGCAGAGTAATATCTGGTACATTGTAGACACTCAGTAAATGTTTGTGAAATG


AATAGAGTGACCAAGCAATCTAATGAATATGGTCCTATCATGGTCCCAACCAGTCATTGGACTGAGTATAGTTTTGATGGTGTCATC


TCAAATGAACATATCTCAAATCACATCCAGGTTCAGCAAATTTTCTTCTCTGTCTTGCCAAGGTGGGGGCCCCACTCTGAGTCCCAG


AGATAGAAACTCCAGTCATCTTTGCATTTCTTTTACTTCCTTAGTGTCTCTTGTATTTTCCTCTGTTTTTCTCCATTCCTACTGCCT


CTACTCTAGTTTACACTGTTGGTCACCTTATGTCTGTAGCCTGTGAGCTAGCTTGCTGACACGAGCACCCCCAGCCATCCTGCACTC


TGCCGCAGCCAGATCAGGCTGCCTCCCACATCCCTTCTAATAGGACGTCCCTGCAGATGGTCAGAGTGGGTTTTCCCAAGGAGTTCT


GCAGGGCGGTGTGTTCCAGTGGACATCCTTGGTCCCCTGAGGACCAAGGCTTAGAAACTGATTTTATGAGCCTAGCCAGAGCTAATC


TCTCCATCGTGTTATCCCAGTTCAGGAAGTGCATATATAAAACCAGATTGTCTGCTTACTGCCTTAAAATGAGAATAGAACTGTTTC


TATTTCCATTTCATGGCCTGGGATTCTGGTGTGGGAACATCTAGTACACATTTTCTTCCTGTAGTCAGGCCTTCGTGGGAAGCCAAA


TCATAATCAGATGCTTACTTGGCTGGTATGGAATAAAAACAAAGAGAAGTGAAGTGTCAGATGGCATCAAGGTTAAGTCCGAGGCAT


CCATTTCACAGTCAGGAGGCTTGCCAGTGGGAATACCCCAAGTGAGTTGGCTTCAGTTGCCTGCATCCTTCTCCACAGTGAGGCTGA


CTTTGCCAGTGGGTCCTGACCCTCCAAGGCTCAGGAGGTTGCCTCAGGCCCTTTCTCACTACATATTGCTGGGAGTGGCAAGGCCAT


TGCTGTTCTCTTTGACTATCTGCTTTCCTCCACTTTCAAATCTGACCAAGCCCTTCTGATTGACATTCTTACCCTTAGATATAATAC


TTTCAATTCTTTAGGGCTTGGAGCTGTTTCTCCAGGATGATTTTGCATGTCTTGGCTTTTTAAAGTTTAACTCTAAGAGCAGTATGC


TATCTTTATTTCAAAGCCTTTATATCTTCTCTCCCTCACTCACCATCTCCTTTCCTCAAAACCCTTTTAAGCCCTAACTGTTATTGG


TGGGAGTCTAAATTTCTTTGCCTAGCCTCTGAGGTCCTCTGTCTGCCTCCCTGAGTGATCCAGACTTCTTTTCTTTTTTTTGTGGTG


GGTTGGTGGTGGGCTGGGGGTGGGGGACTGTCGCCCAGGCTGGAGTGCAGTGGAGTGATCTCGGGTCACTGCAACCTCTGCCTTCTG


GGTTCAAACGATTCTCCTGCCTCAGTCTCCCAAGTAGCTGGGACTACAGGCACGTGCCACCACGCCCAGCTAATTTTTTGTACTTTT


AGTAGAGATAGGGTTTCACCTTGCTAGCCAGGATGGTCTCGATCTCCTGACCTCTTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTG


GGATTACAGGCGGGAACCACCGTGCCTGGCCTCCAGACTTATTTTCTACTTGTTTCCCTGTGGAATAAGAGGACTGGGTCAGAAGCC


CCAGCATAAGTCATTCTGTCTGTCTGCTGGAGTTTCCTGAGCTCTAAAAACCCATCTTGCCTATCTCATAGGATTGTTGTGAGGGCC


AAATACAGTGACAAGTGTTCATTTTCTCTATTGGTGCAAGATTCTGCGTAGGTGATGTGACTCCTTTTTTTTAAGCTATCATATATT


GAGCCCAAGCAGTGTGCATGTATTATTTCATTTAGTCCTTTCAAGTAGATCCTGTTGTCATCCCCATTTTACAGATGAAGAAAGTGA


AACTCAAAGAGGCTAGAGAAGTCTCAGGACTGATGGAGACCAGATGAGTCTGTTTAATCCCTTTAGTCTGCTCTGAACTTCCAGTAC


CCACGGCTATATTGGACTGAACACTCGCCTGACCAGGCCCCCCGCCCCGCCACCACCGCCAACAACTAACTGAACTCGTTTCTACTT


CTCTGACCCACTGCCCTGGCCAAAGTCCTCCCTGCCTTTCCAGGCCCCTTTCAGGTTTCCTCTCTCTCCTTTTGTGTCTAGCCCTCA


TTGCTCACCATCATCTTCTCTGACCTCCTGTGGTACTTGAGGACATACTGGAGGCAGACCCATCTGCGATTACATCCCAACCGTGCT


GTGTTGCTTTGAACAAGGCAGCCACATCTCCGAACCACTGAAAAAAGGCATAATAATGATAGCTGGATCCTGGGATTTCTGGATTCT


GTAAAACCAATTGTGTAAAAGTTCTTTGTAAATGGTTAGATGTGCCTGGTTTCTTCAGTAATCAGTTATTTTTGAAATTATTTTTAA


TTTGTCCCATAGTAAGGAATATATTTTAATGTTGTGATGGGCACATACATTTTAATTAAGAGTTCCACAGGAACATTTTCTTCTTTT


TTTGTGTGTGTTAAAAACAGTGTTTATTTTGACCCATTTAATTGATTTTGACTATCCACTGTAGGAGGCTACCCACAATTTGGAAGG


AACCATCGGGCCTAGATGACAATAAACCCTTTGAGGGCAGGGAATGTATTTTGCACTTCTGCGTCCTCATAGGCCCAACAGGTTACG


AGAAGATCCAGTCTGTTGATGGATTTTGTGCTGGGAGTAGGCAGGATGGAGAGACTTATTCAAATTTCACATTATTTATTCAGTGCC


CCTTTGCAAGAATTGGCCAGTTAAACCCTGGGGGGCAGCTTTGTAGCTGCACTACTCGGGAGCCTGCACCCTCTTGAAGACATCATG


CCAGCGTCTCCTGCACTTGGCCGTGTAGGCTGCAGCACAGCTGTTTCTGCTACAATCAGCTCCAGTATTTGTATTCCTCCTCTTGAG


GCCGAGGCTTGTTCGTTGGCCCCAGGGAATGTGTTGTGTTGGGGTTTGAATCTCCTGTCCTGCGTGCGGTGCCCCTGCCAAGGGCTG


TGCACCCACCTGTCCCAGATGGGTCTTGCGTCATGTTTTCCCTGCTATGCTGGTGGTGACAGCATCCTGCTGTCTCAGAGTAAAGCT


CAGCTGCATATATGCCACCCGCCCTCCTCCACAGCATCCAGGCTTCCAGTGTAAAAGCCTCTTACAACATCAGGCGGGAGAAAACAA


GCCTGCCGCTTGTGGTGCCTTAGCACCAATTTGTCACCCACTTCACTCAGCCCTGGCCCCCTGCTTCTCCTCTGTATGGTATCTTTT


TTTCCCATGGCTGCTCCAGCTGGGCTCTGGCCTGACACTGGAATCACATGTTTTGGCTCTAGCCTTTGGTATTATTCTCGAGGTTGT


CAGCATACATCCCCACTGCCATCTTTTTCTAATGCAAAGGTCTTTTCATTAATGGATATTTTTTCCTGTGAGACTTGTTTAGGGGAG


AGATGCATCCCTCATTTCCCCACCCCCACCCGCCATAAGGTTTTTACAAGCCAAGCTAGAGATTGCTTTCCAGCCACTTTCAGAAAA


ATGCTGGGGCTCCACTTTGTGTTTAGCACAATCAGCACACATAATTCTTGTTCTGCTTGGGCTCTGTTCAATGTCACTTGCTCCTCC


TGACCCTAGAAAGAGTTGAGAATTATAAGCACGGATTATAAGGACTCATAATCTCAGTTGCCAGAGTAAGGGAAATAACGTTTTCAC


CGGTTCCCTGAAATAGACCTGGCGGACAGCTGTTGCCTCCCCTCCCCTTTCCTCTCATTTCCCCTGGAGATGTACTCTGCCTGTTTC


TTCTCCTCGCTAAAACTAAGGAACTTTCCCTTGTGTTTTCTTTTGGCTTCTAGATTGTTCACTTGGCTTTTTATCTAAGCTTGTATT


AAATTGCTTCATGATCTGTGCCTGCAGAGGCTTTGGCATAACATGGCTCACAGAGAAGTGTTGTTTGTTGTGGTTGGACCACTTTGT


TGCAGCAGCATCTGTTCTTGTCTGAATGGGGCATGCAGGTGAAGCATGTACTCTAGGCCACTGAAAAAGGAGGGAACACAGGCACCT


GGACTGACCATTGGCAGCTGTGATCTACTTATGTGACTCTCAGACAGCCTCTCAGCTGCTTGTGATAAAGGCTACAAAATTCCAGGC


AGCTTTTTGGTCCCCATAACAAGTATATATAACTCCTACTTTAAGCAGTCCAAATTTAATACAGAGCAATGGGATGAGATGTATGTA


GGTGGTGTCACATCCACAAGAATATCTTTAATCATTATTCTTTTCAGCAATTCAGTTTCAAGAGGAATAAGTGAATTTAGGAAATTT


GTATATGGGAAAACATTGTCAATCAGTAAATGCGTGGTCTACTGTGTATATTTTCTCCTCAGTTCTTTAAGGCCCCCAAAATGGGAT


GAAAATTTGCTCAAAAGCTCTCATGCAAAATTATAAGAATATGGAGATATATTAGGAAATGCACAGATAAATATGCTTTCAAGAATC


TTATTAAAGTGCTCAACAGTTATATGAAACATGCAAGTATAAGTTGAAAATTTAACTGACATGTGGACATTGAATGTTTCTGTGATT


TTAATGAAAAAAAATTCAAGGAACAAGGGGGAAAAACACCAACCGTCAAAAGGAAAAATGCCCTCTATCTACTCATGCAAATAGTCC


CCTTGTTCATAGCAGTCACAAAGGATATGACGAGCCATATTGTGCAGGATCCAAGGTTCATGAGAAGTAGGTTTGTAGGTGGCAGGT


AGTGGGAAAGTGATTTATGTCCCATGAAAACCCATTCAGCTGTTGTAGCACTTCCAGGGCCTGTGACGTGTGAGGGAGCCATTGTCT


TAACACTCAGGGTGAGGACAAAAAGGCTTCAGTTGCTGAAAGGTGCTGGTTTGAGATGGTGATATCCTGTCTCTTTTTCCAGCAGAA


GCAGGAACATGATGTCTAGGGTTTTTAAAAGAAAAAGCTTTTGTTCTTTTTTATTTAGTGACAGTAGAAATTAAAGTAGGGCCTTAA


AAATTAGAAACACACGTGAACCCCAGGGGGCGAAGCCTGCAGTGAGCCGAGATCATGCCACTGCACTCCAGCCTGGGTGACAGCAAG


ACTCCATCTCAAAAAAGAAAAAAAAAAAAAAATTTAGAAACACAGTCAATTTTAATGTCAAGACCCAAGCCTCAGCAGTTAAATCGG


ATGCCTCCTTAAAAAATGTGTGAAAGTTATTTACCCTCATTTCAATTTGGGGCAACAAATGAATGGCTACTTAGGTTAGGTGTGGGA


AGCATTAATTAATAATGGGATAAAAGGACTCAGTGAGATTAACTTAGATCACCTATATTTAGCTTCTGATTTTACTTCATTCTGTTT


CCTTCTTTCATTAATCTAAATTAACTGCCAGAATTGCATTTATTAGTATGTAGGAGAACAATAATCAAGAAGTGTTTTTATTTATAT


TCGTAGGAGGCTATGTTGTTATTCATGTGATTCTTAGAAAATAATGGATTTTACACAGGAAAAGATGTTTATACTTTTCAAAGATCT


TACTCATTTGGGGTAAGAATTTGATAGAAATGCTAGGATTTGGTGTATAGAAAAGCATGTAAACTGTATGTATCATTTAGGTTTCTA


ATGCCTGTTATTGGCTTTCATGTAATTTGGATTGGGAGTCTAGAAGGAAGGCAGTGATAACAGGAGGGGCTGGGGAAAAGTGAAATT


GTTGCCCATTTCTTCAATATAGTGTGATAACTGTCTCCCATTTAATTTTGTCTCATCACACGTTTTTTGTGTGTGTGTCTGCTTTTT


GCCAAAAAGTACTTACTGGTTCTAGGCCTCAAGGAGCTTATGATTTAGCACAGATTTTCTCAGCCTCAGCACTGTTGACGTAGTGGG


CCAGGTAATTCTTTGTGGTGGGGACTGTCTTGTATATTATAGAACATCTAGAGACTTCCCCAACCTCTACCCACTAGATGCCAGTGC


ACCCTTCCCCAATAGGGTGACAACCAAGATGTCTCCAGATGTTATCGAATGTCCTCTCAGCGAGGCCCAGAATTGCCTCCATTTTGG


AACCACTGGTTTGACACAGCACGTCTTGCTATAGAAACTCACTAGCATTCTTTGCCATTACAGCTGTTCAGTTACTTATGCTTATTT


CTAGTTTTGGAAAAGCCATTTGAAAATGCCCTGAAGTGATTTTTATTCCATTCTCATAATTCTTGAAAAGTGTGTGGAAAGCTAGAG


GAGAACTGTTAACTGTGTCTGTGTGCATGTGTATGTGTAGGGGTGTTTTCATCATTGTCATCGTTATTTTATGAAGAAAATGGAGGC


CTCAAATGTATGAGCCAAAGGACAAACACTGAGATGTCCATGAGAAAGCAGGGCGAGGACTGCTTTCAGGAAGTTCCTGATATTTCC


TGTATTAACACAATCTGTTAAGACCCTGAAAGCTTAGGGCTTAATAAAATCGTTGAGATCTTAAATGTAGAGGATGTAAGATTTTTT


ATAGATCAGCTTTAAAATGAAGCCTAGGCAAAAATGAAGTAGATTTGCCCCTCTTCACCCTCACCTGCCTTCTCCCGGTTTCTTCTC


TTTCCCTCCTCTCATCTCTGCTTGCTCTGGCAGTTCCTTTAACAAACATATTGTTATGTGATGACTTTGATGAATTACAAACAGGTA


CCTCTCTTTCAAGATACATTATATTCATCTACCAAAAAATGGTCGTAATAGCTGTACAAAGCTGCAGTGACCCACGGTAACTGGAGC


CCCAGGAGTTGTGCAGTGCACAGCTTGCACAGAGTAAGTGGTGGCTATGTTTGGGCAGTTTCATTCCCTCCCATGACATTAAGCTTT


CACCTGAATGCTGTTCTGTTTTTGACCCTAGACCAAACCTTTTCTGGGAACATCATGCCTATGTAAGCTACCTTTTGGACACATTCT


TCCTAGAATACTCTAAAGCATCCCAAGTGTAACATATGCAAAATTGAATTACTGTTTTCCCCAAGCCTGGTTTTTCTTAAATTTAGG


AGTCGTCTTAGTCTCTCTTTTTATATACTTATATACACACACTATACACATACACATGTATGTATCACAAGCCTTCTCAGTCCTCCC


CGTATAGTTCTTAAATCCTGTTTTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTTTGAGACAGAGTCTCGCTGTGTTGC


CAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCTCTGCAACCTCCACCTCCCAGGTTCAGGCAGTTCTCCTGCCTCAGCCTCCTGAGT


AGCTGGGACTACAGGCATGCCCCACCACGCCCAACTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGTACAGGATGG


TCTTGATCTCCTGACCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGCACCCGGCCTGTGA


TTTTCTTTCTACCCCTGCTTTCCTCCTGTTGTCTTATTTCAGTTTTCATCTCCTCTCTCCTGAGGCCTGGGCCATTGCAGTCATCTA


CTACCTGCTTTTCCTGTCCAGGTATCACACCCCTTCAAGCATGTTTCAACTAGAATGCTCTTGTAAAACACAAATCTGGCCTTACTG


TTTCCCATCAGAGCTCTTTGAATTCCTTCTGTTATGCCATAGTTTATGCCTCCTTTATAGCCTTATTTATAACCTCATCCCCTCCCC


TCAAATGTCTAGGCATTCAAAATCTGCAAAGTGCAGGGCCTGTTCTAGGCACTGGAGACTCAGCAGTGAATAAAACAAAGTCATTGC


CATCATGGAGCCTACTTTTGAGGGGGCTGGACTATTCGCAGTTCTGTGAGCTGCCATGCTGTTTCGTACCTTTGCTGGAATGTGCCT


GCCCACAGCTAATCTTCCTGGACAGTGTCTGCTGGAATTTCAGGACGCAGCGACGGTGTAGTGACCCCACTAGCATTACCACTCTTC


TTTTTATGTCTTCCTTGTGTTGTGTGCTTCAAGCTTCCTCTTCACCAGGGCCTGGCCTTACCAGGCTTTGTGTTTCCAGCACCTATA


GTAGTGCTCAGCGCATAACAGATGCTTCTAAATCTTTATTGAATGAAAAGCACACAAGCATGGAAACACTTTGGGATCCGTGTCCCT


CAAATGTGTCATGTATTTTCTTCCTTTCTTTGCTTATACGCTTTCCACTGCCAAGAATATCCACCCCAACCATCCTACCAGGCCCTT


ATAAGCCACTTGCCCCATTCTTTAAAGTGTCGCTGTCATAAACCCCTGCTGAACCCTTGCCTCAATTACTTATTGACCTACTTGCPT


TTTTCATGCTTTCAGTAGCATTTATTCAATAAATACTGAATATCTACCATTTTCCAGGATTTGTGCCAGGTCCTAGGGATATGACAA


TGGAAAAAGATCTGCTAATATTGTATTTTTAGTAGAGACAAGGTTTCTCCATGTTGGGTCAGGCTGGTCTTGAACTCCCGACCTCAG


GTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTATAGGCGTGAGCCTGGATGACTGTCCTTTTTGCAGTGATGTATAGGCCC


AGGCCCTTTCCACGTTATGGCTCTGCTAGCCCCATTGTGTTCCGTTTTATGTGAAAGGGTAAAGAAGAGAGCATGGAGTGGATATAT


TTGTTTCTTAAGCCTTGCCTCAGAAGTGACACCTACCACTTCTCTCACAGTCCATTGGTAAAGACAAGTCACAAAGCCACTCAAAAC


TGCAAGGGCAGCTGAGACATGTGGTCTAGCTGGGTGACCAGAAAGACAAAATGGAGTTTTGGTAGACAGCTACCAAACTCGGCCACA


TACCTCATTATACTAGCTGCAAACTGTGTTATCGTTAGTTGCCTGCATATTAATTAGTTCCTTCTGCTTAGAACACTTTTATCTAGA


ATATTTGCAACATTTGCCACTCACTTCATTTAAATCTCAGCTCATCTGAAACTTCTTCCAAGTGTAAGACCACTCAGTCTGGAAAAG


CTCCCCATCTTCCTACACTGCCTTTTTTACTTTAGAGCCCCTGTCACACATTATATTATATATATAGTTTAGTTTATTGTGCTCCCC


TGCACAGGAATGTAAGTGTCATGATGGCACAGCATTTGTTTTGCTCATTGTTCTATCTACAGAATCTAGAAGAGTGCCTGGCACTTG


TCTTCAAGGATTATCCACATCCTGAAGGCAGAGCTTTGTTGTTCACATTTCAGTGAATATTTGCTGAGCGGAGCCTCATGCTAGACA


GGCCTTGGAGGCACGTCCTAAACAAGGAAAACACGCCCCCTGCCTCCCTCAATTGAAGATATTAGTCTCTTCAATCTCATTCAATTT


TATTTCTCTGTGCTTAGCATTTAGAAGCAATTAAATATGTTTGTGGAATGAACAAACTAATTAACAGCATATTTAGAAAATCTCCCT


GTAGTAAATATATTAAAGTTTTAGAAATCATGATAATCTAAGTGAAAATATTTTACAGATTATGGGGAAAACATGAGGGATGAAAAT


TTACCCTGCTCTGCTTTAGCTTTTGAAAAAGTCTGCTTATGAGCCACTCTCTTCATTGCTAATAATAACACCAGTGGGGGAAACTTG


AAGAAAGAGGTATTTGTCACCAAATGGTAAGTTAGCAGCTTGTCTTGTTATCTGGGTTGGAACACAAAGTCATTAAGTGGCATTTGG


ACTAAATCTGATTGGAATTTAGAATCTACTTGGAGACAAACAAAATATACTTCTGCTTAGAAAAATTACATTTTCCACTTTAAGATG


TTGTGGATTAGAAAATGATAAGAATTAATTTTAAGAGAACGCCTGTTTTTTGAAAGGATTGGTTATATGTTGGTGGAAATTCTTCAG


GGAAGTGACATCTCTGGAGGGGGAAACACAAAAACAGCTCAATACAGTCAGTCAATTTATTCTACACTTAAGGAAAAAATAACTAAG


TCTGCTTGCTGGTTTTCTGTGGGCTGTTAACAGCTGGTTGACTCAAATTTCTGCTTTCTACCAATTGTGAAAATTAAGCTTTAATTT


AGAGGAGCACCTGGATGTTGAGACTCTGTCTGAAGATACAGGGGCTAAAAATGTTCAGATTCTGTCTGAAGATACAGGGGCTATGGC


TTGTCTATGGTTACAGTTTTTGCAAATGCAGAAAAGCTTTTCGAGCCTACTTATGTTATGGAGTATTTCCAATAGTGGTTATTAAAG


TAATTCAAGGAAAATCAGTAACTAATGATAATAAAAAAGTTGCCTTAAAATAGTGTTCAAGAAAATAGAGTGTGTATGTCATATTTT


AGCACATAGAAAGGCTTAAACCCTCTTGTGAACTCCTACTTAACCATTTCTTTATTATACTCTTCTTACTCAGATTTATAAATTTTC


CTTCCTTTCTGCAAAAAGACAGAGATAAATAAAGATACTAACTTTTCCCCGTCATTATATCACCCCATTACCCTGTTATGACAGTAA


TATTCATGTTGAATATCCGGTCATGTTTAGCCATTTGTATTGTGTTTAAAGTTATTTTTTATGATTTCCAAATTTGAAATACTGGAA


AGGAAGATCCCAGCCTGATGGAAATTTTTACCAGAATAGTGATTCCTTTTTGCTGTAGAAAACATGGGAGGGAAATTGTCTTAGTGT


CGTTACTGTCTAGTAATACTGTTTGAATTCTTGAAAGGCTTGTTTCCCACGGTGTTTTACTGCATTATATTCATGGAAGGGAACATG


CAAGCCAGAGACAGTACAGGTTTTAGGCAAAGAGGCATGGGTTAGGATTCTGCTCTGCCACTCTGAAGGGAGTTATTTCTTCTGGCT


TATTCTGTGTCTTTGTTATTTAAGTGAGGGCATTTACAGGACCTACATCATAGAGTGCTGGGAGATTAAACAAAGAGACATTCACAG


GTTATGCCCTGCTGCTAAAGAAAAGGAATTACCATTTTCAATTTGTTGTCTAAAGACCATCTGAAAATCTTGCTGTCCCTCAGTTAG


ACTCTGGCCTATCCACAGTAGGTCAGCTTGCCCACATGGGTTTCAGCAACTCCACTCTGCTCTGAGGCTCGCTAAAGGGTGAACAGG


TGATCATGAATGTGGAAGGCTGAAGAAGAAACTGGAAAAAGCTGAAACTGAATATCAGCATTTAGAAACTGCATTTGGAGTGCTGAG


ATAATAGAAAGCTTTCAAGGCACTTTGGAACTCTACATATGTTAATCAAGAGCCTCAAAAGCAGCCCATCGATTGGCAAACCAATCT


CTTCAAGTGCCACCACATTAAAGTCCCTGGGGAAGCTGTGGATATTAGCTAGCAGCGGTGCACAAGCCGTTTACCCTCCCTTCGCTG


CAACTTTAAAAACTTTTTGCCTAATAATCTCTGTTCTAAATTCAGTATGGATTTACTTAGCCAGCAGATTGACATCCAGGGGGACAG


TGTGAGACTTGGAAGAGTTTTATATTTACAGGAAAGTTGCAAAGATAGTACAGTTTCCATTTACTGTGCACCCATTTTCCCCTGTTA


CTAACACCTTATGTTAGAAATGCTTGTTCCCTGGTGCTGCAGAGAAATAAATGTATGAGCATTCGAACATACATTTAATAAAAATGG


CCTTGCTAAGATGATTAAATTTATGTTCGAGTGCTGTTTCTTTGCGTCACCGGGGAACAAGTATTTCTAACACCTTACATGTTAATA


TACTGCATTTGTTACAACTAATGAGCCAATATTGATATATTATTATTAACTAAAGTTTGTACCTTATTCAGACTTCCTTAGGTTTTA


CCTAATGTCCTTTTCTGTTCCAGGATCTCACCCTGGGCACTACATTACGTTGTTCATGGTTTCTTAGGCACCTCTTGGCTGTGACAG


TTTCGTAGACCTTTTTGTTTTTGATGATCTTGACAGTTTTGAGGAATAGTGTTTAGGTATTTTGTGGAATGTTCCTCAGATTTGTCT


GTTGTTTTTCTCATGATTAGACTAGGGGAAGACCCACAGAGGTTAAGTGCCATTTTTGTTGTATCAGGGGTACATCCTGTCAACATG


ACTTATCACTGATGTGATCATGTCAACATAATCTTGATCACGTGGCCGATGCAATCCGCTGCCAGATTTCTCCACTGTAAAGTGACT


CGGCCCACCTCCTTTGGAAGGAGGCCACTACGTACAGCCCTTGCATAAGGAATGGGGAATTTTGCCCTTCCCAGTTGTGGGCAGAAT


ATTTACATAAATTATTTGGAATTCTCAGTTGTATTTCTAAGTGTGTGATTTTAAAAACTACTTGGATGTTAAAATGGTTACTGTTGT


ATTCATTATTGAGTGAATACTTACAAATGTGGTCTGATGAACATTTTATTCTACCTAAGGGAAAAAAACAGCTTCCCAAATTGCAGC


CACCCTGCCTAGTTCAGAGACTGTAGAATTTGTATTCCTCCCCGAGTGTGTTCTTAGTAGCACGCCAGAAGTGCCAGATGCTACCCT


CTCTTTTTCTGTGTCATGATTTAATACCATTTGTGCATTTTCTTCTGCTTCAGTTGATTTAGTGTCATTTTTGGAGACCACAGACCT


ATTTGTATTTTATATGTTACTATACAGTGTGTATTCTGTTTAGAAAAATAAAAACGCTAGTATGATAAAATGTACTATTTTATTATC


TTTATTTTTAAAGTGTTACTATCAAAGACATCCTTTGGTGTCTCATAATTGGCTTTGACTTTGTTGCTCTCAATAAGAGTATATGAT


TCCAGATTTTCTGTTTAGTCAATGTTTAAACTACTTCATGTTTAACATTTATGCACATTATAATACAATGTGGTAATAAGGGTCATT


TGGCTTCTTGGCTCTTTCAAAATATTGGTATAATTTTTAACAAATTTATTTTGAAATAATCATTTCACTTTTTGATGAGTATAAACT


TGGTGAGAATTAGAAACTTCTTCAAAATATAGAAGTCTATTTTCCTTATCTTTGGCAAAGAATGATAATAATTGGACTTCAAAAGAC


CCAGCCCAGTAGTCCCCACTGCTAAAAATGAATAATGGCCTATCTCAATCCACAGAAGGAAAATAAAATGGGCTAATAGAAACTTTT


TCAGTTTCATGTTTTTCTCCTGTCAACATTTCATAAGTGTTTGGCATTTGCTACCACATCTCTTTTGGTGAGTATTAGTGAAAATGA


ATGAATAAGTAGTAAAAGAATGTTAACAGAAAAATTTGGACACAACCAGTTAGTTTAATAACTCTATTATTTTATTGAGAACACGCA


AGTTTAGGGTATGGTGTTTTTTTATTCTTTCTTAGGGTTGAAATAATCTCCCCTGCCAGGTACGTATAAGCTATGGTTTTAGATGGC


ATTCATATACTGCCATTTCTGCCAGAAAAATTATTCCTCGTTCATAAAAAGAAGCAAAGTATCTCAGTGTTTCATATTTTTCCTCAA


TAGGCAGCTCTGCTTCCCAGTGCTTTATCATCAGAGCAAGTTTGAAACCCACCACGTGGGTGAATGAGATGCAGTTAGGGAGTCTCT


GCGAGCTTCCTGAGACAGGAAAGCATGGGTCATCCTAAAGTTGTATAACAATCATCTGTGTATCCTTCTACAGGAAGGATGGAATTG


ACTTTTCCACCCACAGATTTGGCATAAAATGTCTCTGCATCTGGGGCCAAGACAGTGTGTAAGGATTGTGAAGTCCCAGTGGTTTGG


GTAGTAGGTGAAGATGCCAGTTCAGTGCTGAAGAGCCATTCCTACCTGTGTGTGTGTGTGTGTGTGTGTGGGGGTGCTGTGTGTGTG


GGGGTGTGTGCTGTGCACGTGTGTGTGTGCGCACGCACGTGTGTGTGCGCGCGCGTGTGTGGAGTGATTTTTCACTCTTTTTGCAGG


GAGGAGAAAAGAATGAATTAGTAGCTTTGCTTTTGCTAAGGATATCCTAACAGTGTGGTGGATCCTTTTTGTTTAACAGGGTAGGTC


AGATTACTGAGGAGCTGTTGGTTTATTGTTTTGTCATTAGTGCCATGAAGCTGCTACCGCTGGTTGTGGGTAAAGCAAGGCACATGA


AAGCAGTCTGAAAATTTGTATTCAAGCTAATTTTTAATTTTTAACTACTTGTTTACTTATTTCTATATTTACCCTTTTAGCATAATA


CCTGAAAACTTAAGGGGTTGGGAAATATCATTCATACAGCCAATTTTTTTTAATACCTTCTGTATTCAAGGCACTGTGCTGGGGAAA


CACAAGTGGATAAGATGGACATGGTCTCCATTCTCATGATGCATACAGCCTACTAGGGGAGACAGCTGAAAAACAACTACAGATATA


ATTAGAAGGAATAATTTCAGGAAGTGTGGTTAGTAATATGAGGGGGGAATAAATTCGCAAAGGTGGCCAGAAAAGACTTTACTGAGT


TATCATCTGAAACAAACCCTTAGGGTAGGAGTACCCTGTCTTTATAAAGGAGAGAAGAAAGAGATGCAATTAGCAGGATGATTGACG


TGAAAAATTGCTTGATATAGTCAAGGAATAGAAAGTAGGCCTGTGTGACTGGAGAGAGTGGTATGATGTGAAATTGGAGAGTTGGTA


GAAAGGAGAGCACAGAGATCCTTAGGGATTATGAAGTATCGTATGGTGCACATACTGATGGATTTTCACAAACTGAAGAAACTCTGT


AACCAGCACCCAGATCACGAAGTTGGACATGTTCAGTACCATTGGGGCTGCTGGAAGCAGTAACCACCCACGCTGTTAGCTCTCTTG


TGTTCACATTTCAGGGCCTTGCTTTAGGAAAACTTCTGGTGTTCTCAGGCTATTTCTTCTATTACCATCCAAGGCCTAACACTTCTA


GCTCCAAGCAGAGTATCTTTCTGTGGGATTTTTATACTCATGTCACTTCCTCTCCCCAACCCCCACCTTGAACATGTATTATACATG


GAATTCTTTGGTAAATAGAATGCAAATTTGTTTTCAAAGCTTGTTTGGCACATACTCTCTCCTTTAGAAAGCAAAGGGTGTCCTTTC


AGAAGGTTCTTATAATATTTGTGGATCTGGCCTTCAGGTCTAAGCTGAAGCTTTTGTTTTCATTTGGACTTTATGCATGTATTAACA


GTTTATATTTTCTGTGGTAATGGAATATTTTAGGGGTTGTTTCTTCATTATATTTAGATTCTTATATTAAAAAGCGTGCAAAGGCAT


TTAACCAAATTTAATCTAGAAATAAAGATAATATGGTAATTTCAAATAGCTTTTTGTTCAAGATGAGATTTTAAAAGTTATTATTCC


ACAGTGAATTTTAATGATGATTGTGTACAATGGCATTTATGGATGTGCAGCAATTGAATGAGTATGATTAGCGCGTTAGATTATGGA


TTTGTAATGTGAAATGAGAACTTTTTAATAAGCTTTCTCCATAATGGTTCACGCTGTGAACAAACAAAGTATGAGACACTGAGCTTC


ACTAAATCATTGCAGGGCTTTGGAATCAGTAGGTTCATGTTTTCAAATAGTTTCCTATTTTTAAAAACACCGCTAAAAAGTTAAGAG


GCAGCTACATAACTAGATATCTTATATTTTGAGGAGTTGGAAGAACATGTTTCTTTTTATAATAAAAGGAAAATGTTATTGTTGAAG


TATATTTATTGTTCAAGTATAAAATGGAATTGAAGTTATGCTTTGAGAAAAACTTGATTGCAAGACCTTATTAGGATTTAACACCTC


ATCAAGACTGCTTTTTACATTTTTTTTTTTATTTATTTTTTTTTTAGATAGAGTCTCGCTCTGTCACCCAGGATGGAGCGCAATGGC


ATGATCTCGGCTCACTGCAACTTCCGCCTCCCCAGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCGCC


TGCCATCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCGTCATGTGGGCCAGGCTGGTCTCGAACTTCTGACCTCA


AGTGATCCACTTGCCTCAGCCTCCTAAAGTGCTAGGATTACACGCGTGAGCCACCGTGCCCAGCTGCTTTTGACATTTTCTTTGGGA


GGTTTCTGGGGTACAATTAGCTGAAATCTGAAGTTTGGTTTTGCATGGTCTTGCCCAAGCTGGTGGTTGGTCATTGTGGCCTTCTGA


TCTGGTGATCCTAAGAAACATTCTGAAAACATACCCAAAAACACATAAAAGGCGTACCTTACCATTTAAAGGTTCTTTCAGTAAAGG


CCTATGAGTAATTTTTCATGGAGGGAGCCCATTCTTACGAAGTTTTAATGGACAAACATATCATTATCTTTAAATTGTATTATTACG


TTGTCTTTTATTTTTAAAAGCTCATTTTTCCCCATTATCAAGATAACATGTTCTAGACAGACAATTTAGGAAATGCATATGATTATT


TTTGTTCTAATTTTCTGTAATACCACCACATAGAGACAGTAGTTTTTAAAAACTGTGTGATATTTAATGTATTGTTTTCATTTCCTT


TAAGATGCAATTTAGAGTTTTAGCCTTGAACTTTAGTTTTCCTTCCTCTTGGAGATTTAGTTTGATGCTAAAGTGCTATCTTCTTGT


TTCAACTTTTGCTTAATTTACTCCAACACTTTTAGACAGCAAATTAGGTAACTTTATACTAGTGTTATCTAACAATGTTTTGCTAAC


TTCCATTTTAAGATGTTAGCTCACAAAAAAAGCTCTTAATTTAAATACATATAAAATTTTGAAAATGTGTGACTTTAATTAAAGACC


ATTGTTGGCTAGCATCATGGAGGTGTCAAGAAAATTAATAGTAAATGGGCCAGTCATCATTTCAAAACTTTCATGTTACATGACAAC


TGAAATTCCAGATACCCTTTAAGAGGTAAACTAGTTATGGAGAAGGGATGGAGAAGCACAGAATCCTAAATTTACTGTGGTTAGTCA


TGCACTCTGTGAGATGGAGGTTATTAGCCTCATATACCTAAAAATATATCCAGTGACCAAACCATGTCATAGGGCTCTGTCCATTTC


TTGCCTTTGCTTTCTCTTGGACTGGCTTCATTCTTAGGGTATCCTCATGTGGTTTCAAGGTAGCTACTAGCAGCTCCTATTGTCTTT


CCCATGAGTTTAATAACTGTAGTAAATGAGTCTCTCTTTGAAAATACTTGAATAGAAATCCCAGGATGAGTCTTACTGGACAAGTCT


TAAGCACCCACTAGTCCCAAACCAATTGTTAATGTGAGATAGGTGGAATGCTGTGATTGCCAGGATTGGGTCACATCCTTACCATCT


TACTCTAGAACACCAGCTTATTGCCCAAAGAAAGACCAAGGTGTTGTAATTGGAAAAAGGGAGGCAGACTACAAGCACACAGGAAAA


CTTCCTGGGTGTTCACTAAAAAGGTCGATGAAGAATGAAGCATAATTCCTTGAATGAAAATGAAAATACAGCATAGTGAAACCTGTG


AGATACTGCAAAAGCAGTACTAAGAGGGAAGTTTATAGCACTAAATGCCTACATCAAAACAGTAGGTCACAAGTTACCTAACATCAC


ACTTGAAGGAACTAGAAAAATAAGAACAAACCAAACTCAAAGTTACAAGAAAATAAGCGACAAAGATCAGAGCAAAACTACATGAAC


TAGAGACCAAAAAACAATACAAAGGATGAGTGAAATGAAAAGTTGGTTTTTTGAAAAGATAAACAAAATTGATAAACCACTAGCTAG


ACTAACCAAGAAAAGAAGAGAGAAGATCAAAATAAACACAATCAGAAATGAAAAAGGAGACATTACAACTGATCATGCAAATATAAG


ATCATCAGAGACTATTATTATTAACAACTATATGCTCACAAACTAGAAAAGCTGGAAGAAATGGATAAACTCCTGGGGACACAACCT


CCTGAGATTGAAGAAATAGAAGCCCTGCACAGACCAATGATGAGTAGTGAAATTGAATCAGTAATAAAAATCTCTCAACAAAAAAAG


CCCAGGACCAGATGCAGTCACAGGCAAATTCTTTCAAACATACAAAGGAGGCCAGGTGCAGTGGCTCATGCCTGTAATCCCAGCACT


TTGGGAGGCCGTGGTGTGTGGATCACGAGCTCAGGAGATCGAGACTATCCTGGCTAACACTGTGAAACCCCATCTCTACTAAAAATA


CAAAAAAAAAAAAAATTAGCTGGGCGTGATGGTACCCACCTGTAGTCCTAGCTACTTGGGAGGCTGAGGCAGGAGAATCCCTTGAAC


CCGGGAGGCGGAGGTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCATCTCAAAAAAAAAA


AAAAAGAAAAGAAAAAGGAAAAAACCATACAAAGAAGAACTAATACCAATCCTCCTGAAACTATTCCAAAAAAAAAAAAACGAGAGG


ATTCTCCCCACCTCATTCTACAAGGCTAGTTATAACCCTGATACCAAAACCAGACAAGGATACAACAAAAAAGAAAACTAGAGGCCA


ATATCCCTGATGAAAATATATGTAAAAATTCTCAACAAAATACTAGCAAATTGAATCCAGCAGCTCATCAAAAACATACTATACCGT


GATCAGGTGGGATTTATCCTAAGGATGCAGGATGATTCAACATGTGCAAATGAAGAAATGTGATACATCATGCAGACAGAATTAAAG


GACAAAAACATATGATCGTCTCAATAGATGCAGAAAAAAGCATTCAGTAAAATTCAGCATCTCTTCATGATAAAAGTCTTCAACATA


CGAGACACAGAAGGAATATACTTCAACATAATAAAGGCCATATATGACAAACCTACAGCCAACATCATACTTAATAGGAAAAAGTTG


AAAACATTCCCCTTAAGAACTGGAACAAGAGAAGCATGCCCACTTTCATGACTCTTATTCAACATGGCACTGGAAGTTCTCACCAGA


GCAATCAGGCAAGAGAGAATAATAAAAGACATCCAAATTGGAAAGGAGGAAGTCAAATTATCCCTGTTCACTGATGATATGATCTTA


TATCTAGAAAACCTTAAAGACTCCACCAAAAAACTCTTAGATTTGATAAATCAATTCAGTAAGGTTTCAGGATACTAAATTAACATA


TAGAAATCAGTAGCTTTTCTGTACACTAGTACAGTAATGATCTAGCCGAGGACCAAATCAAAAAGTCAACCCCATTTATAATAGCTA


CCAAAAAAAAAAAAAAAAACCCAGCTGGGAATATATTTAAACAAGGAGGTGAACTACAAAACACCGATGAAAGTAATCATAGACAAC


ACAGACAAATGGAAAAATATCCCATGCTCATGGGTTAGAAGAATCAACATTGTTAAAATGACCATCTCCCCAGAGAAATCTACAGAT


TCAATATAATCCTTATCAAACTTACCAACATTATTTTTCACAGAATTAAAAAACCCAATCCTAAAATTCATATGGAACCAAAAAAGC


CAGAATAGCCAAAGCAATCCTAAGCAAAAAGAAAAAATCTAGAGGCGTCACGTTACCTGACTTGAAATTACACTACAAAGCTATAGT


AACCAACAACATGGTACTGGTATAAAATAGACACATAGATCAGTGGAATAGAATAGAGAAGCCAAAAATAAAGCCACATATCTAAAA


CAACTGATTTTCAACAAATTCAACAAAAATGTACACTGGGGAAATGACACCCTATTCAATAAATGGTGCTGGGAAAATTGGATGTAT


GTTGTAGAAGAATGAAACTGAACCCATACCTCTTATCATATACAAAAATTAACTCAGGATGGATTAAAGACCTAAACGTAAGACCTG


AAACTATAAAAATCCTAGAAGAAACCTAGGAAAAACTCTTCTGGACATTGGCCCAGGCAAAGAATTTATGACCAAGTCCTTAAAACC


AAGCACAATGAAAATAAAAATGGAGAAATGGCACTTAATTAAATTAAATTAAAAAGATTCTGCACAGCAAAAGAAAAAAATCAGGAG


AGTAAACCTACAGAATGAGGAAAAAAAAATTCCCAAAGTATGCATCCAACTAAGGGCTGACATGCAGAATCTACAAGAAACTCAAAC


AACTTAACAAGAAAAAAACCCCAAAGAACCCCATTAAAAAGTGAGCAAAAAACATGAACACACATTTTTCAAAAGAAGACATACAAG


TGGCCAACAAACATGAAAAAAATGCTCAACATCACTAATCATCAGAGAAATGCAAATTAAAATCACAACGAGGCCAGGTGCAGTGGC


TCATACCTGTAACCCCAGTACTTTGGGAGACTGAGGTGGGCAGATCACAAGGTCAGGAGTTTGAGACCAGTCTGGCCAATATGGTGA


AACCCTGTCTCTACTAAAAATACAAAAAACACTAGCTGGGCGTAGGGCACCTGTAGTCCCAGTTACTCAGGAGGCTGAGGCAGGAGA


ATTGCTTAAACCCGAGAGGCAGAGGTTGCAGTGAGCCGAAATCACACCACTGCACTCCATCCTGGGTGACAGAGTGAGACTCTGCCT


CAAAAAAAAAAAAAAAAACAAAAACAAACAAACAAACAAAAATAAAACAACCACAATGAGATACCTTCTCACACCAGTCAGAATGGT


TGTTATTCAACAGACTAAAAATAACAGATGTTGGTGAGCATGTGGAGAAAAGGGAACGCTTATACACTGTTGGTGGGAATATACGTT


AGTACAACCTCAGTGGAAAATGGTATGGAGATTTCTCAACTAAAAATAGAACTACCGTTGGATCTAGCAATCCCATTTCCGGTATCT


AACCAAAGGAAAAGGAATTATTATATTTAAAAACACCTCAAGTCATATGTTCACCACACTGCTGTTCACAATAGCAAAGATATGAAA


TCAACCTAAGTGTCCATCAGTGGAGGATCATTGGATACAGAAAATGTGGGTTACACACACACACACACACACACACACACACACACC


TTGGAATACTATGCAGCGATAAAAAGCAATGAAATCTTGTCTTTTGGAGCAACATGGATGGAACTGGAGGCCTTTATCATCAGTAAA


ATAACTCAGAAACAGAAAGGCAAATGCCACACATTCTCACTTGTAAACGGGGGCCAAATGATGGGTACACATGGACAGACAGAATAA


AATAATGGACATTGAAGACTAAAAATAGTGGGAGGATGGGAGGGAGGTGAGGGTTGAAAAATTATGATTGGGTAGAAAGTTTACTAT


TTAGGTGATGGGTACATTAAAAGCCCAGACTTTACCACTAGGCAATATATGCATGTAAGAAATCTGCACTTGAACTCCCTACATGTA


TTTTTAAATTTTAAAAATTAAAAAAAAAATTGCCACTGTGCCATTAGCTGGTACCATGTAATTTAGCATATAACTGTGTACGGATCT


CTTTTCTCCATCATTGCTTCATCACGTTAATTTTGTTATGATGAGGGACTGTCTTTTACTTTTTTTATATTCCTCTTAGCACTAAGC


AAATAACAGGACCCTAAACACTTAACTGATTTTTCATTTCTGAAGTACAATAAAGATAAGTAGGAAATGTTAATATCATTGTTTTGT


TTGTTTGCTGGTTTTGTTTTTCAGTAGGTGTTTGAGAGAAACACTTAACTCTCTAAGTGAACTAATTTTTTGCCATGAATGTGTTCG


GCACTAGGAAAGGTGATACATACTAGAACTGAGGAACTTAACTGGGGGTTCATATGCTTTCTAAGAGACCGTGGGAGAGTTTCTGGG


CATCTCTGCACCCCTAAAATCCTAGCAAAATTGTGTATGTGTGCACGCTTTTGTGTTTTTTTCTTTTTCTTTTTCTTTTTTTTTTTT


TTTTGAGACAGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGTAGTGGCATGATCTCGGCTGTCAGCTCACTGCAGCCTCTACCTCCAG


GGTTCAAGGGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCACCCACCACCACGCCAGCGAATTTTTATATTTTAGT


AGAGACGGGGTTTCACCGTGTTGGCCAGGCTGGTCTCAAACCCCTGGACTCAAGTGATCCGTCTACCTCGGCTTCCCAAAGTGCTGG


GATTACAGGCGTGAGCCACCACACCTGGCTTCTTTGTGCATTTTTCCTGAGTAAGGATGTGTAGCTTTCATTAGATGCTCAAAGGAG


ATCCTTAATCCACAGAAGGTTCAGAGCCACTGATAGGAAATATTTAACACTGACAGAAAATAGTTCTGAACTTTGCGATTAAATAAT


TTATTGTGAGTGGGAGGAGCTAAAAGAGTGATGCCACTTAGGAGAAGCACAAAGGAATCTGAGCTCGAGGATGAATTGTTAATCTAT


GTTAATGAATTCAGTCTGTACAGGGTTCAAACAAAATATATTATGGATGAGCCTCTAATAAAATGGACTTCCTCTGCTCTGCCAGTC


CGACAGTTAATGATGGCTGGCAATTTTCTGCCGGCTGATTTTGGCTCAGTGCTTTGGAGCAGGCACAGGCCCAGTTCTCGCCACTTG


GAAGGAAAGGGAAAGTGATAGTTTGTTACTTTGCTCTCATAAGCAATTTATGACAACAGTTTAATAAAAGCTTAAGAAGTGTCCTCT


TCCTGGGCGGGGAGAGGAGCCGAGGAGCCTCAGTGGGAGCACCGCGTGGGATGTTAAGCCCCTCAGCATCTCCTGGGGCCGCCTGAC


GCTGCCACACAAGAGAAGAGCGAGGGGGAGCCAGCGAGGTGTTTCTTTTAGCCCAGGCAAGGCTACTGTTATGCTTCCCAATTTGAC


TTTTCCCCAGCAAACTCAAGCTGTCCTGTGAGTTTCCACATCAGCCGTGTGCCTCGGGAGCTGCTCCGAGCTTGGGCTCTGGTGCTG


TCTGCTGCATGGACCTCATTAGCGCTCACCCAGCAGATTGCTTTCATATCGCTGCTTCACCCTTTTCAGTTTTGAATTACCACATAA


ACATCAGATATTGGGGGTTTTGTGAAAGGATCCTTAGTCTCTAATATTTAGTTAAGGAAAAAAGCCCTCTTAGGGAATCAGATAGAT


TTGCTTAGAGGATTTCCTCAGGAAAATACATTGCAGTATGGGTCAGTTCTAATTTTCCTCAATTCCTGAGGCCATTTAGTTTTCACT


TCTCTCTCTCTCTCTCCCCACCTCAACCCTGTGAGTCCAGGTTTAGGGGATTTTACAGCCAGCCTTCACACAACTTTCTGCTCTACA


TTTGTGGCCTTAAAACTTTATGATTTATAGGAAAGTATATTTCATGTCATGAACTGGGATATAAATATGTATGTATATATGTATAAG


CAAAAAGGTTTCACAAGGCAATATTTGCCCTTATATACCATAGTCTGATATTTTCTATTCTGTCGGGGAATACTGCTGGTCTTCACT


CATTAAATCATTTTCATGGCTCACCAATGGTTTGCACCCTGCAGTTGGAAAACACCTCTCAGGGATACTCAGGGATCCGTCCTTTCT


ATCACTGTGTTGAGGGATGGCTCAGGGCACCGTGTAGTGGCTGAACCTCTTTATGTGGTACAGCAGAACCAACTTTATGTATTTTCA


GTAACACTTCTGATATTCTGGAGGGAGTAGAGCATAGTGATTTAAGAGCGAATGTTCTAGTTAGAATATGCTTGCTTGGTCCTGGGT


CTCTGACCTACCACCTGCTCTGGTGTTGGGCAAGTTTCTTAACCTCTCTGAATCAGTTTGCCCTTCTTTAAAATAGATATAATTTGA


ATACTTATAGCGAAACATTGTGAAGATTGAGATGTATATTATTAATACATTATTAATATATCCTAATGCACATCTATTAAGACACAA


TACAGAATTAATATTAATAGCAAACATTTGTTCAATGTTACTATGTGTCTGTGGTAAATTTAACAAATGTTTGCTATTAACATTATT


AATACTGTATCTTAATATTTATGTGTATCTCCAGTTGGATTACATTTTCCTTCTGCCCTTTGAAATAACTTATGTTGAGCCTATTAA


GAATATGTGGGTTGGGTGTGCTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGTTGAGGTGGGCATATCGCTTGAGGCCAGGAGT


TCTAGACCAGCCTAGGCAACATGGTGAAACCCTGCCTCTACAAAAAATACAAAGAAATTAGCCAGGTGTGGTGGCACACGCCAGTAG


TCACAGCTACTTGAGAGGCTGAGGTGGGAGGATCACCTGAGCCCAGGAAGCAGAGGTTGTAATGAGCCGATATCACACCACTGGACT


CCAGCCTGGGTGACAGAGCAAGACCCTGTCTCAAAAAAAAAAAAGTCTTATGTGTAGAAATAATCCCTATGTTCAAAAGCATGAACA


GTAAGCAGTGTGGTTAAATGAAAAAATATATATATTGCAGCTAGATAGTTACATTTTGAATTAGGACATTTTCAGCTCTAAGTGACA


GAAACCCCAATCAAACTGGCTCAGGCAAAAATAGGAATTTACTGATTGACGTAACAGAAACATCTAGGGATATTGCTTTTGGCATTG


GCCATTTCCAGTTGCTCTGAAGGTATCAGCAGTTTTTCTCTTCATTTCTTGCTCTGCCTTTCTCTGTTGGCTTCTTTTTCAGGCAAG


CTTGCCCCCAAGCAGTGGCAGAAACAGCCACCAGCTGCTCTAGGTTTCTGTTTCACTAGCAGGAAGAAAAACCCTCTTCTCTGGTAA


TTTCAGCTTAGTCTTGCATCTGATGGACATGGACTTTGGTGGGCTAGGCTCAGCTCACCCCTCCTGACTCCTTGCCACTGTCGGTCA


CGGAGCCATGAGAGGCACTGGTCATTAGATGTCCTGGGTCATGTACTTGCCTTGTAGGCTCAGCCCTGTTCAAGCCACAAGGTCAGA


ATGGAGGAGGGCTGCTCCATGGGGGCATCTCAGCAGATGCCCATCACACACTTCCACCATCCCTCCCCTGAACATAAGACTTCCTAC


ATAGATGTTTTCTTTGAATAATTCAACTGAGAGTAGTGTTAACACCTAGATACTTCTTATTCCAAGATATACCTCATTTCCACTCTT


AATTTAAATTATAGCTATGTTCAAAGATGTGTCATCCCTTCCTTCCTGATCACTGCTAAGATGTTCTTTTTAGCCACCCCGTCTTTG


TATTGCCACTTAAAAGTCATCATTTCCTTCTATCTCATTTTATGCCTCCCTCTGCTTTCGCACACCTTTAGTACTTGTTGCCGTCGT


TATGAACAGCAAAATACAGACATGTGACACCCCACCTCCTCAGCAGTCTATCCTTTTCATTTTGTGCTCTAGCCAGCCCAGGGGTCA


GAACTGCATTCTGCAGCTTTTCTTTCATTCTCTGGCTGTGAATGAGGGTCCCTGATTTACCAGACTACATGAGGTTGGGACTGTGAG


TTGTTGGACAGGCCATGGCTTCCCCTATACACACACACACACAGACACACAGATGAAATGGTTGACAGTGGACAGTTTGGTTGCAGT


AGGGACTCCAGATGGTGAAGTGTGTCTGCCAGGGAGTTAAAGAGAATTGTGGGTCTGGAGCCAGTGAAATTGAGGGCACATTCCAGA


GCTTACGTCTGCCATGTGCAAGATATGTTTAGCTTGCTAATTAAATTAGGAACAAGGTAAGCACTTGTTTGTTCATTCATTCATTCA


TTCATTCAGAGACAGGGTCTTGCTCTGTCACTCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGCAGCCCTGAACTCCTGGGC


TTAAGGAATCCTTCTGCCTCAGCCTCCCGAGTAGCTAGGACTACAGGCGTGCACTACCACACTTGGCTAATTTTTAAAAATTTCTTG


TAGAGACAAGATCTCACTATGTTGCCCACTTTGGTCTCGAACTCCTGGCCCCAGACAATCCTCCTGCCTCGGCCTCCCAAAGTATTT


GGGATTACAGGTGTGTGCCACTGCACCTAGCTGACATTTTTTAAGCCCAATATTGTGATCTAATATTCTATAACTGTATAGGATGGA


TAAATCAAATGTCGTGAAGTTCACATATAGAAAAGGTATGGATTCAGGTAGTCTCAAGGTATGCATTATTTGGGGGAAAATTAGAAA


AATTCCCTAAAGACATTTAAAAATTCTAAAGTAGGCTGGGTGCAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGCA


GGTAGATCACTTGAGGTCAGGAGTTCAAGACCAACCTGGCCAACATGGTGAAACCCTGTCTCTGCTAAAAATACAAAAAAAAATTAG


CCTGGCGTGGTGTCGGGAGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTCAACCAGGGAGGCGGAGGTTGTG


GTGAGCCGACATCACGCCACTGCACTCTAGTCTGGGCGACAGAGGGAGACTTCATCTTTTTTTTTTTTTTTTTTCTAAAGTAGCAGA


ATTGTTATGTATGTATTTATGGATGGGTGTATATATATGTATATTAAGAAATGCTAGTCAAAGTGCAGATATGATTTACACATTATC


TAATGGAAGCTTTCTAACCCCCGACCCCATAGGCACATCCACGATGCGAGAACACAGGCTCATGCAGAGTTGAAACGCTGTTGCCAA


ACTAAATCAAGACTGATAATTGGCCAGTTAGCTCAAAGAGTCAATGAAAATGATGAGGGTGTGTGTAAAATGACACATACTTTACAC


ATTTTATTTTAAATGAAAATACGATTTTGAAGTAGTATATTGTCTAGCATTTTGGTTTTTTCCCTGCTCGTGCTGTGTGCATGGAGA


CTCTGATATTTTTCCCCCAGTGGTATGTCACTTGCTGTAATATTTTGAGTACTAGGAATGTTTTGAGATAGGCCCAAGGTCTTTTTC


TTGTCTAAGTGTCCTCTGACTGAAGTATCTTCCTTGTGTAAACTTCAGCCATAATTTGTCAGCCACAACTTCCATTTACATTTTTTT


AGGTGGACCTAGAACTCAGCAATACTTGCAAAGTAATCTAAGTCGGGAGGTTTTTCCAGAATTTTTCCAGTGTTATGCAAGTTGTCT


CCGTCACACCTCATTCAACAGCAAACTTTTGTCATGGTTTGCCTTCATGGAGTCTTTTTTTTTTTTTTTTTTTTTTAAAGAGATGAG


GTCTCACTGTCACCCAGGCTAAAGTGCAGTGGCACGATCATAGCTAATTGTAACCTTGAGCTCCTGGGCTCAAACGATCCTCCTGCC


TCAGTCTTCTGAGTAGCTAGGACTATAGGCATGTACCACTGTGCCTGGCGAATTTTTAAGTCTTTTTGTAGAGAATGGGTGTCTTGC


TGTTTTACCTCCGCTGGTCTTGAACTCCTGGCCTTAAGCGATCCTGCCACCTCTGCCTCCCAAAGTGCTGGGATGACAGGCATGAGC


CACTATGCCCAGCCTGCCTTCATGGAGTCTTTACAAGGCATTTAGCTTAGTTTTTACAGAAACAACTATTTCTTGACTTCCATATTT


AATTGATTTTATATAATGCTTGCACAGTATGCATGCAAAGCAAGTACACTTGGCACAAAAGATTTGAAAGGAAACATAGCTCAACCT


GGAATAAGCACACAGCTCCATGGGTGGAACGGATGTGAGCAGATGTGTTGGCACTAGGACCACTGGTAGCTCACACTTAGGTGGGGC


TGTGTGTTCTAAGTTCTTTGTATACATTGACTCATTTCATCTTCACAGAACCCCGTCAGGTAAGATATTATTATCCCTTTACACAGA


TGAGGGAAGTTATGTACAGAGAGGACAAGAGATTTGCTTCAGAGTGGCCTACTAGCTGCCAGCATTCAGCCTGCATTGGGCTTTAGA


CAATATGTTTTGCGAAGGAATGAGAGCATTTTGTGTGGGGGTAAATTAAGAGCACAGAGACACTATATAGAGATAATCCCTTAAATA


AAACCCACCATAACACATAAAGACTTCTGAAATACTCTCCATATCTCTCTAAAATTAGAGTCTAGGCTTTTAGAGGTAGAGATGACC


TTAACGTATCCCCTGCATATCCCAACAGGATAACCAAGACCCAGATGGGTGAGGTGATTTGCTTCACAGGCACCCAAGAAAGTGTGG


CATAAAGTTTAGTTTCCTGATTTAACCCCCATTTTCCTTCTCTCTCTCTCTCTCTCTTTTTTTTTTTTTTTTTTTTTGAGACAGAGT


CTTGCTCTGTCACCCAGGCTGGAGTGTAGTGGCATGATCTCGGCTCACTGCACCCTCCCCCTCCTGGGTTCAAGCAATTCTCATGCC


TCAGCCTCCTGAGTAGCTGGGATTATAGGCATGCCACCATGCCCAGCTAATTTCTTTGTATTTTTAGTACAGATGGGGTTTTTCCAT


GTTGCCCAGGCTAGTCTCGATCTCCTGGCCTCAAGTGATCTGCCTGCCTCAGCCTCCCAAAGTGCTGGAATTACAGGCGTGAGCCAC


CATGCCCAGCCTATCCCACATTTTCTTATGGAAGAAAAGGATGCATTGTAGTGTATATGTAATCTTCTGAGAGAAACATTCAGGAAA


TGAGCCTCTCAGAGTTTGCCAAGAGAGCAGGAAGGTTGGTGGATAAGGACCACCTTAGTGTTATCAAATCCACATCTCTCCTGCAGT


CAGAGTAAAGCCTGTACCAGGTAATCTTAGGACTAGAAAGGGTCTAGCGATGTGGTTTTATCCACCCCTGTCTAGAGAAGGAGGGAA


TCAGGCCAGCTGAGCACCAACAAGGTAGATGGTTTTGTCACTATTTTATGGGTAAGGAACTTGAGCTTCAAAGAGAGAAAATGATTT


ATCCAAAATCACACTGCTAGAAGGAAATGGAACCAGGACACAAGCCTGGTCTTGCTGAAGCTAAGGCCCGTGTTCTTTATGCCGTGC


TAATTGTTCATCCTGTGCAGTTGTTTAACCACAGTTTTCTTGGCTAGAAGTTCTTCCTAAAGTTAACCCTAAATATCTCTTGAATTT


AAATGTGTATCCTTCTGTAGTCCTCAGTCAACAAAAGAAGCGATTGATCAGCCTATTTGAGAGGTTATAAGAAGACACAGATTGGCA


GTGTTTGAATGTCAGTAGTACTCATCAAATAATCCCAGGATAGAAGGCATTTTGTTCAACTCCCCATTATCCCTGCTCACATTTGCT


CTGTAGCATCCCCACGAAGCCTGTGCTGGGTAGTTTTCAGTCCGGGAATTAAGAGATATAAGAAAGAGGGGGCTGGGCACGGTGGCT


CACGTCTGTAATCCCAGGACTTTGGGAGGCTGAAGCAGGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGCG


AAACCCCATCTCTACTAAAAGTACAAAAATTAGCTGGGCATGGTGGCACGTGCCTGTAATCCCAGCCACTCAGGAGACTGAGACAGG


AGAATAGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCTACAACAGTGAGACTCC


ATCTCAAAAAAAAAAAGGAAGAGGGAAGTCACCACCTTAGCCCATCCCATCTTCTTCCCAAGAGGTCATACACACATATGCCGTCTT


TGATTTGTATTTGCAAAAGTAATTCATGTTTATAGTAGAAACTTGGATCACTGAAGAAAGCTCAAGAAAGAATTTGAAAATCTATGT


GTATGAGTTATCTATTGCTATATAACAAGTTACCCCAGAATTTAGCAGCTTAAAACAAACTTTTATCTCCCATAGTTTGAGAGTCAT


TAGTCTGGGAGTGGCTTAGCTGGGTAGTTCTCTCATGGAGTTGCAGTCAAGCTGTGAGTTGAGGCTCTAGTCACCTGGAGCTTTGTC


TGGGGCTGCAGGGTCTACTTTCAAACTCACGTGAGTGTTGGCAGGAGACTTCAGTTCTTGCCATATGGGCCGCCTCATGGAGCTGCC


CACAGCATGGCTTCCCACAGAGCCATGTTGATGAGAGAGAGAGAGAACACGCACTAGAGAGCAACCAAGACACAGCCACAATCTTTT


CTACGCTGATCTTAGAAAGGATGTTCCTGCACTTCTGTTGTATTCTGTTGGTCACACAACCAACCCCGGTATAATATTATAGGAGGG


GACTACACAAAGGTGTGAGGACCAGGGATGGGAATCATTGAAGGCCATATCGAAGGTTGCCTACCACAGCATGTAAATTAAAATTAT


GTTGCAATAAATTACATAAGTTTTTGCCCACAGTTCTCCTTTTCTTCCCCCTAGAGTATTGCAAGATACAAAAGATCACCAGGAAAA


AAAAAATCTAAAGGGAATGCAATGTTGAGGCATGAATGTCCCAGTAAGCTGTTTATTCCTTTCTCATTCTAGAGGAGCTTCTTGATT


TTATTCCAAGTCTGCCATGTCAAAATTGTGGTTTGGGGAAGAGGGGAGTAAGGGCAATAGAGTGGATAGAAGCATGTGGATGCGCCT


TGGTCCTGACATTTGTGTTTTGGTGAACCTGCTGCCTCTGAGAAAAGATAAGGAGTTTAGGATTTGGTCCAGGCTGAAACCTGGGAG


AAGCTCATGGCTCCTGGACCTCCTTATTCTGCTTTTAGATGCAAATAAGAAACAGAGATTTGTAAATGATATTCTAATTTTTACAAA


TAATTATTTGAGGAAAAAGATTTGACTACTTCAAACATACAAGCATTGAAAGTAACATAAAAGGTTTTTTGGTTTTTTTTTTTTTTG


GTGGGGGTGAGGGGGAGAAGCATTTTGTTTATGCAAATACAGGGTACAGAGATCCAGAAGGAGATCATAACATCTGGACAAGCAGTA


GCATTCCCCAGCCTCCCACCCCCAACTGTTACAGATAACAGAGGAAACTTGTGGGTAAATAAGTAGTAGGTAATACAGGCATTTATA


GATAGGGGACGTTTTCATATCAGACACGGCAGAGCTTTTTTTGAAAAGCACATACCTGTATGATATTTTGATGAATAAAGGTAATGC


AGAAGCAAACTGTAATATCAAATAAATTTGAGTGAATTCTTCTACAGTACCTACAGTCAAAGGAAATTTATCAGTGAAAATCAGTAT


ACAACAAACAGCAAAATGGAATAAATTTGAATAAATTCCTGCACAGGCAGTCACAGGACATGTTGATAAATATTTCAGTATAAACTG


ATACAAAGTATAGCATAAAATATTAATTTTGAAGGAATTCCTATGTCATGCCTTGAATAAAAGCTAATATTTCACTGAATAGTGTGT


ATGTACCAAGCAACGGGAAGAAAACTGAATTAGTTTTCACAAAATGGCTCTAACTTAATGTGTATAACCATTTTTCAGCTGACTTTG


AGCCACAGGTTGCAGTAGTCATATGGATGTGACTCTTAGATGTCAGAGGAATGGCCCTGCTCTGGTGGCGGGGTGGCTGTTGGCCTC


TGTCCCTGTCCATCCTGTGGACCTTTTTGTGGACTAAGGAGCTGATGTAGTGAACTGGTACTGCTGGTGTGTGGCTTTCTGGACCTG


CCTCCCTCAGCCAGAGGAGACCCTTGGATTTCTCCATCCTAAGCCAGACTTACTGATGGCCAAGAGTGAGGAGCAGGCAGAACAGCC


ACAAAGTAACTGCTTTGCTCTTTGGCTATGCCCTAAAGTGTCCAAAGTCATTGTTCTAAAGTGGAGCAACTACATAACTGACAGTTA


ACCTCTAGAGCCCTGTACAAATCCTTCCTTTTAGTCCAGATGCTATATGAGTTTGGGGAACCTGAGCCTTCCTGTGTGCACGTATTC


CCCTATTGCTGCTGATGCAGGGAAAACTGTGCCCAGTAGTGACACCATCCAGCACCTCAGGTGCCAAAGTCCCCAGGCCGTGATCAC


AGAGCATGGGGCTGAGCCCCTCATAGGTGGTCACATCACCCTCTTTGTCCTGCTGTCGGCTGGAATGTGTCCAGCCTAGCTCAGCAT


GGAAGAAGGTGAACCCCACCACCTACCATGAGCAGCACCTCAAATGACAATGCCACAGAGAAAATGGAGCAAAACCAGGATGACCTT


GCCAGCTCTTCATTGTAGGATCAATGCATTTAGGTGCAGAGGGGTGTGGATGGAAGCCATGGCCTAGCTTGGCTTGTCGCAGACCTC


TGTGCCAGGCCCTTGCCACCTCCTAATGCAGACAGCAAATACTGGAGGCCTGAGCATCAGCTCTTGAAGTAGCTCTCTGGGAGGGCG


GTGAGGCACATGTTGAGAGCATGGGATTTGCCAGCAGAAAGATCTTCAGTGAATTACCTAAGCTCATTACACCTTAGAGTCCTCATC


TGTAAAATGGGGCACTTGCCTAATGAGGGTGTTATGAAAATTAGCATATTTAAAGGTACTAGGGCTGTTTCTGGCACATTGTCAGGG


TTCAGTAATTCTAGTTAAAAATAGAAAAGTGGCTTCTGGCTGGCAAGATGGCCGAATAGGAACAGCTCCGGTCTGTAGCTCCCAGCG


AGATCGACTCAGAAGGCGGGTGATTTCTGCATCTCCAACTGAGGTGCCCGGTTCATCTCACTGGGACTGGTTGGACAGCGGGTGCAG


CCCACAGAGGGCAAGCCGAAGCAGGGTGGGGCGTCACCTCACCCGGGAAGCGCAAGGGGTCGCGGAATTTCGTCCTCTAGCCAAAGG


AAGCCGTGAGGGACTGAGCCTGAGGAACTCCGGCATAGATACTGCGCTTGTTCCACAGTCTTCGCAACCCACAAACCAGGAGATTCC


CTCCGGTGCCCACCCCACCACGGCCCTGGGTTTCAAGCACAAATCTGGGTGGCCATTTGGGCAGACGCCGAACTAGCTGCAGGAGTT


CTTTTTTTCCATACCCCAGTAGCACCTGGAACGCCAACGAGACAACCATTCACTCTCCTGGAAAGGGGTGCTGAAGCCAGGGATCCA


AGTGGTCTGGCTCGGCGGGTCCCACCCCCACAGAGCCCAGCAAACTAAGATCCACTGGCTTGAAATCCTCGCTGCCAGCACGGCAGC


AGTCTGAGCTCCACCTGGGGCACTAGAGCTTGGTCGGGGGAGGGGCGTCCGCCATTGCTCAGGCTTGAGTAGGTGGTTTTACATTCA


CAGTTTAAACAAAGGCACTGGGAAGTTCGAACTGGGCAGAGCCCACTGCAGCTCAGAAAGGCTGCTGGGGCCAGACCGCCAGATTTC


TTTTCTCTGGGCAGAGGATCTCTGACAAAAAGGTAGCAGCCCCAGTCAGGGACTTATAGATAAAACCTCCATCTCCCTGGGACAGAG


CACCCGGGGAAAGGGGTGGCTATGGGCGCAGCTTCAGCAGACTTAAATGTCCCTGCCTGACAGCTCTGAAGAGAGCAGCGGACCTCC


CAGCACAGTGTTTGAGCTCTGCTGAGGGTCAGCCTGCCTCCTCAAGTGGGTCCCTGACCCCTGTGTATCTGGGAGACACCTCCCAGT


AGGGGCCGACGCACACCTCATACAGGAGAGCTCTGGCTGGCATCTGGCAGGTGCTCCTCTGGGACAAAGCTTCCTGAGGAAAGATCA


GGCAGGAATCTTTGCTTCCGCTGGTGATACCCAGGCAAACAGGGCTGAGAGTGGATCTCTAGCAAACTCCAGCAGACCGGCAGCAGA


AGGGCCTGACTGCCAAAAGGAAAACTAACAAACAGAAAGGAATAGCACATCTGCTTAAAGACCCCATCTGAAGGTCACCAACATTAA


AGACCAAAGATGGATAAATCCACAAAGATGGGGAGAAACCAGCTGAAAAAGGCTGAAAATACCAAAAACAAGAACACCTCTTCTCCT


CCAAGGGATTACAACTCCTCACCAGCAAGGGAACAAAACTGGATGGAGAATGAGTTTGACGAATTGACAGAAGTAGGCTTCAGAAGG


TGGGTAATAACACACTTGAGCTAAACGAGCATGCTCTAACCCAATGCAAGGAAGCTAAGAACCTTGAAAAAAGGTTAGACGAATTGC


TAACTAGAATAACCAGTTTAAAGAAGAACATACATGACCTGATGGCACTGAAAAAACAGCACAAGAACTTCGTGAAGCATATACAAG


TATCAACAGCCGAATCAATCAAGCAAAAGAAAGGATAGCAATGATTGAAGATCAACTTAATGAAATAAAGAAACAAGACAAGATTAG


AGAAAAAAGAATAAAAAGGAACGAGCAAAGCCTCCAACAAATATGGGACTATGTGAAAACACCAAATCTGTGTTTGATTGGTGTACC


TGAAAGTGACAAGGAGAATGGAACCAAGTTGGAAAACACTCTCCAGGATATTATCCAGGAGAACTTCCCCAAATTAGCAAGACAGAC


CAACATTCAAATTCAGGAAATACAGAGAACACCACAAAGATACTCCTTGAGAAGAGCAATCCCAAGACACATAATCTTCAGATTCAC


CAAGGTTGAAATGAAGGAAAAAATGTTAAGGGCAGCCATAGAGAAAGGTCAGGTTACCCACAAAGGGAAGCCCATCAGACTAACAGT


GGATCTCTCTGCAGAAACCCTACAAGCCAGAAGAGAGTGGGGGCCAATACTCAACATTCTTAAAGAAAACAATTTTCAACCCAGAAT


TTCATATCCAGCCAAACTAAGCTTCATAAGCGAAGGAGAAATAAAATCCTTTACAGACAAGCAAATGCTGAGAGATTTTGTCACCAC


CAGGCGTGCCTTACAGGAGCTCCTGAAGGAAGCACTAAACATGGACAGGAACAGCCGGTACCAGCCACTGCAAAAACATACCAAATT


GTAAAGACCATTGATGTTATAAAGAAACTGCATCAACTACCAGGCAAAATAACCAGCTAGCATCATAATGACAGGATCAAATTCACA


CATAACAATATTAACCTTAAATGTAAACATGCTAAATGCCCCAATTAAAAGACACAGACTGGCAAATTGGATAAAGAGTCAAGACCC


ATCAGTGTGCTCTATTCAGGAGATCCAACTCACATGCAAAGACACACATAGGCTCAAAATAAAGGGATGGAGGAATATTTACCAAGC


AAATGGAAAGCCAAAACCAAACAAACAAACAAAAAACAGGAGTTGCAATCCTAACCTCTGATAAAAAAGACTTTAAACCAACAAAGA


TCAAGAGAAAAGAAGGGCATTACATAGTGATAAAGGGATCAATGCAGCAAGAAGAGCTAACTATCCTAAATATATATGCATCCAAAA


TACAGGAGCACCCAGATTCATAAAGCAAGTTCTTAGAGACCTACAAAGAGGATTAGACTCCCACACAATAATAGTTGGAGACTTTAA


CACCCCACTGTCAATATTAGACAGATCAATGAGACAGAAAATTAACAAGGATATTCAGGACTTGAACTCAGCTCTGGACCAAGCGGA


CCTAATAGACATCTACAGAACTCTCCACCCTAAATCAACAGAATATACATTCTTCTCAGCAACTCATCACACTTATTCTAAAATTGA


CCACATAATTGGAAGTAAAACCCTCCTCAGCAAATGCTAAAGAATGAAAATCACAACAAACAGTCTGTCAGACCACAGTGCAGTCAA


ATTAGAACTCAGGCTTAAGAAACTCACTGAAAACCACACAACTACATGGAAACTGAACAACCTGGTCCTGAATGACTACAGGGTACA


TAACGAAATTAAAGCAGAAATAAAGATGTTCTTTGAAACCAATGAGAACAAAGACACAACATACCAGACTCTCTGGGACACATTTAA


AGCAGTGTGCAGAGGGAAATTTATAGCACTAAATGCCCACAAGAGAAAGCAGGAAAGATCTAAAATTGACATCCTAACAACAAAATT


AAAAGAACTAGAGAAGCACAGCAAACAAATTCAAAAGCTAGCAGAAGACAAGAAATAACTAAGATCAGAGCAGAACTGAAGGAGATA


GAGACACGAAAAACTCTTCAAAAAAATCAATGAATCCAGGAGCTGGTTTTTTTTTTTTTTTTTTTTTTTAAGATCAACAAAATGGAT


AGACCACTAGCCAGACTAATAAAGAAGAAAAGAGAGAAGAATCAAATAGATGCAATAAAAAATGATATAGGGGGCCGGGTGCTGTGG


CTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGCGATCGAGACCATCCTGGCTAACATGGTG


AAACCCTGTCTCTACTAAAAATACAAAAAATTAGCCAGGCTTGGTGGCGGGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGACGCAG


GAGAATAGTGTGAACCCGGGAGGCAGAGCTTGCAGTGAGCCAAGATCGCGCCACTGCACCCCAGCCTGGGCGACAGAGCAAAACTCT


GTCTCAAGAAAAAAAAAAAAAAAAAAAAAAGATATAGGGGATATCACCACCAATCCCGCAGAAGTACAGACTACCATCAGAGAATAC


TATAAACACCTCTATGCAAATAAATGAGAAAACCTGTAATAATGGATAAATCCTGGACACATAACACCCCCCACAAGTCTAAACCAG


GAAGAAGTTGAATCCCTGAATAGACCAATAACAAGTTCTGAAATTGAGGCAGTAATTAATAGCCTACCAACAAAATGTCCAGGACCA


GATGGATTCACAGCCGAATTCTACCAGAGGTACAAACAGGAGATGATACCATTCCTTCTGAAACTATTCCAAACTATAGAAAAAGAG


GGAATCCTCCCTAACTCATTTTATGAGGCTAGCATCATCCTGTTACCAAAACCTGGCAGAGACACCACAAAAAAGGAAAATTTCAGG


CCAATATCTCTGATGAACATTGATGCAGAAATCCTCAATAAAATACTGGCAAACAGAATCCAGCAGCACATGAAAAAGCTTATCCAC


CACGATGAAGTCAGCTTCATCCCTGGGATGCAAGGCTGGTTCAACATACACAAATCAATAAACATAATCCATCACATAAACAGAACC


AGTGACAAAAACCGCATGATTATCTCAATAGATGCAGAAAAGGCCTTTGACAAAATTCAACACTCCTTCATGCTAAAAACTCAATAA


ACTAGGTATCAATGGAACATATCTCAAAATAATAAGAGCTATTTATGACAAACCCACAGCCAATATCATACTGAATGAGGAAACACT


GGAAGCATTCCCTTTGAAAACTGGCACAAGACAGGGATGCCCTCTCTCACCACTCCTATTCAACATAGTATTGGAAGTTCTGGCCAG


GGCACTCAGGCAAGAGAAAGAAATAAAAATAAAGGTTATTCAATTAGGAAGAGAGGAAGTCAAATTGTCCCTGTTTTCAGATGACAG


ATATTTAGAAAACCCCATCGTCTCAGCCCAAAATCTCCTTAAGTTGATAAGCAACTTCAGCAAAGTCTCAGAATACAAAATCAATGT


ACAAAAATCACAAGCATTGCTATACACCAATAACAGACAAACAGAGAGCCAAATCATGAGTGAACTCCCATTCACAATTGCTTCAAA


GAGAATAAAATACCTAGGAATCCAACTTACAAGGGATGTGAAGGACCTCTTCAAGGAGAACTACAAACCACTGCTCAAGGAAATAAG


AGAGGACACAAACAAATGCAAAGACATTCCATGCTGATGGATAGGATGAATCAATATTGTCAAAATGGCCATACTGCCCAAGGTAAT


TATAGATTCAATGCTATCCCCATCAAGCTACCAATGACTTTCTTCACAGAATTGGAAAAAACTACTTTAAACTTCATATGGAACCAT


AAAAATCCTAGAAGAAAACCTGGGCAGTACCATTCAGGACATAGGCATGGGCAAAGACTTCCTGACTAAAACACTAAAAGCAATGGC


AACAAAAGCCAAAATAGACAAATGGGATCTAATTAAACTAAAGAGCTTCTGCACAGCGAAAGAAACTATCATCAGAGTGAACAGGCA


ACCTACAAGGTGGGAGAAAATTTTTGCAATCTGTCCATCTGACAAAGGGCTAACATCCAGAATCTACAAAGAACATAAACAAATTTA


CAAGAAAAAAACAACCCCATCAAAACGTGGGCAAAGGATATGAACAGACACTTCTCAAAAGAAGACATTTATGCAGCCAACAAACAT


ATGAAAAAAAGCTCATCATTATTGGTCATTAGACCACAAATCAAAACCACAATGAGATACCATCTCACACCAGTTAGAATGGCGATC


ATTAAAAAGTCAGGAAACAACAGATGCTGGAGAGGATGTGGAGAAACAGGAATGCTTTTACACTGTTGGTGGGAGTGTAAATTAGTT


CAACTACTGTGGAAGACAGTGTGGCGATTCCTCAAGGATCTAGAACTAGAAATACCATTTGACCCAACAGTGCCATTACTGGGTATA


TACCCAAAGGATTATAAATCATTCTATAAAGACACATGTATGTATGTTTATTGCAGCACTATTCACAATAGCAAAGACTTGGAACCA


ACCCAAATGTCCATCAGTGATAGACTGGATGAAGAAAATGTGGCACATATACACTATGGAATGCTATGCAGCCATAAAAAAGGATGA


GTTCATGTCCTTTGCAGGGACATGGATGAAGCTGGAAATCCTCTTTCTCAGAAAACTATCACAAGAACAGAAAACCAAACACTGCAT


GTTCTCACTCATAAGTGGGAGTTGAACAAGGAGAACACACGGACACAGGGAAGGGAACATCACATACTGGGGCCTGTCGTGGGGTAG


GGGGTAGGGGAGGGATAGCATTAGGAGAAATACCTAATGTAGGTGACAGGTTGATGGGTGCAGCAAACCACCATGGCATGTGTATAC


CTATGTAATGAAACTGCAAGTTCTGCACATGTACTCCGGAACTTAAAGTATAATTTAAAAAAGAATAAATAAAAATAGAGAAGTGTG


CCTGTAATCCCAGCTACTCAGAAGGCTGAGGCAGAAAGATTATATAATACCAGGAGTTTGAGGCAGCAGTGAGGTATGGTCATGCCA


CTATACTCCAGCCTGGGCGACATAGTGAGACCGTCTTTTAAAAAAATTTTAACATTTAGCCGGGTATGGTGGCACATGCCCCTAGTC


CCAGCTACTCAGGAGGATGAAGCAGGAGGATGGCTTGAGCTCAGGAGTTTGTGGCAGCAGTGAGCTATGGTCTTGCCACTGCATTCC


AGTCTGGACAATGGAGTAAGATCCTGTTTCTAAATATGTGTGTGTGTGTGTGTGTGTGTATAATATGTGTGTATATGTTGTGTAATC


TTAAGTGAATCTAATAACTGCTCTAGTTTACTCTGCAAATGAAAAAACTAGACTAGACAACCTCTAAAATCTTTCTTGATTCTAAAT


ATCTGTGTCTCAGTTTAGCTCCCATTCCCTTATTCCCAAGTCCAATGCACATCCCATCACTTTGTTTCAACTTTCATGGCCGAACTG


CAGGTGGGGTGGAGTGTGCCTCTAGGAAAGTGGAAACGGCTGTGGCTTTTCCACTGTGGCTTCAGGGAGCCCTGGCCTTAATCAAGC


TGCTTTCTAGAGCTGTGTTGCCTCTGAGCCTGTTTCCTCATTTGTATGATGGGGATATCATTGTCTCCTTCACAGTGTGATGACAGT


TAGTCATGTACAGAAGGCACCTATAGCTCCTGGCACAGGCTGATGAGCAACAAAAGTTCACCATTATCACTTTCTCAGTGTCTAGGG


GACATTTCATCCCTGAGCATCTCTGGCCATTTCAGGATGTGCTCACTGTCTCTCATTTGCTCTGGTCCCAGTGACCTTGTTAGCTCC


TGGCAATGTGTGTGCAGGCCCTTCTGCCTACCCAGTCAGGTGATGGCCTGGTGAACAACAGCAGAGTAGGCCCATGCCTGATGCTCA


GTCATTTCACCATCTTTTTCCTGCCAGGTGCCATGTCCAAGATACAACACCTACATCAAGGAACTCAGAGTCTGAAGTCAAGGCTGC


AGAAACTGTGGTCTAGCTTTCTGACCAAAGCTGGGTTTTGTGCTTCTATGGCAGTGTAGATTCTTTTACTTGAACATACTCAAAATC


TTAGTTTTTAATTGGTGATTCTTTTTAGGATTACAGCAGTTTTTGGTCTCAAAGCCAAAAGATTCTGAATTATTACAGATCTTGTGT


TATTTTGTGGCTGTATAACATCTCTTAACCAACCAAACAAGATGAGTAGGTTAGAGATTAAACTGGCTGCAGAAGTCTAAATGAAAC


TGAATCCCCAAGTTCTGAGACGCAGTGAGGAGAAACTGTATTGCCAATAGATCTTCTCATCCTGCATTTGGAGTGGTCGGGATTCTG


CAGTCAGATGCCTGGGTTTGAATTGGGGTTTTCCCAGTCACTAGGTAGGTAGCAACTCTAGTCCAGGCTACTTAATGTCTCGTAAGC


TCAGTTTCCACAGTTGGAAGTGACGATATGGTGTTTACTTCAGTGGTTGTCCTGAAACTTTATTGAAATGACACAAGTTCGTAAACT


GTGCCAGTTCCATTGTAAGGATGCAATAAATGTTAGCTCTTGTTTTTATTAATGACGAGGATATAATGTTTAAACTCAATGCCCACT


TCGGGCAGTTTTTTACCCTGTAGAAGCAGTTGTAATCATTTTCAAATCAGGCTTGCTACACCCTTCCAGCTGGAAAGAAAAGTCTCT


AATTTCATTGATTTTCGAGGGCACATGCTTTAGTTGAATGAGTAGTAACCAAATGGAGATATGTAGTAGGCGGTTAGAAGTGTTAGC


ATCTTTGGGATCATGTGGTCAACCACATTATAAATGAATGCTTGGATGTAAGGGCAGACCTGCATCTGTGTGTGTGTTTTCAGTGGG


TGGATGGGCCATGTGGTATCACAGCGTGCCACACAGGGATTTACGGTGTCAAGAAGCATTTGTGGTACAGAGCTTGGAGTTTGGAAA


GTAAGGCTTCCTTGTTTTGCATCCTGGCTCTACCACTGTCAATCTGTGTGACCTTGGGTGAGTCACTTAACTGTTTCCTCACCTGTT


AAATGTGAATAATAACAGTACCTCTCCCCTTTTGTGAAGACTGAATGAGATAAATGAAAAGCTGTTTGCAGTATGGTCATACTAAAA


TGGGAGCAGTCAGTACCCTCCCCCCATTTCCAGCAGAGTGGTGGGCAGGTCTAGCTAGCCCTTGTACATACACCTTGCAGAATAGTT


TATAGTAGTGAGCATAGCTGGTAAATGTACAATAAAAAAAGTTCCTGTTTTTCATTTCTACCTGATTGAATGAGACACCTATTTAAT


GCAAATTTCAATAATGCTCTGATACTAACTCTGTTCAAGTTAGTAAGAGAGCTTTGTAGAGTTATTGTGACACCTGGGTTAAGTATG


GCTGACTTTGGGTTAAGTATGAGGTCTAATCATCCCAGTCTGTCCTCTAGATTTTTTGCTGTTTTGTTCAATATAATTATGTAAACA


GGTATTCTCTATGTAAACATTTGTGAAAGTTAAAATACCAAAGCAGATTAAATATAGAACTAGACTGGATGCCTACATCAGTGTTTT


AGTGACAGCCCCCCCCCCCCCCCCCCTCATCTGTTACATTTAATTATTTTGGCTAGTTTCAGTTCTGTTGGTTTGATAGTATTCTTT


TTAGTTGATATATAAATTTGCTTGGGGTTTTATACCAGTCTTCTATTTCTGCATATTTAAGGAATATTTTAATAAATAATAACTTAT


GTCAACCTTGAGGATCTATGACTTTTTTCTTTTAAAGAGAGTTCATATATTAGTCCATAACCATTGAATAGATCGTTCAGAGTGTAT


GAAGAAGAGCATAATCCTGTGCACAGCTGGCTTTTCTGATTTGCAGGGTATTTAGTGTACATTTCTCTATCCAGCTCATATGCCGGA


CAGAGGAACACTTTACCCTTCTGGTCTCTCTGCCTGTTGGGCAATTGGGTTATTCTGGGTATGTGGAGGACCTTTTTTGATTCTTGT


TGTGAGGGATGCTTTCAACAGAAAAGAGAGGAAGAATATTTGTCTTTCATTGCTCAATACCCAGATATTTCATATTCATCAGAAATA


GCTACTTCTGAATTCTTTTTTCCTCTTTAAATTAGACACAACATTATCCCGTCTACTGTTATTTCTTTTTTACATTTTTATATTAGC


AGTCGACTGTTGGCATGTTCTCTCAGCTGCCTCTAGTGATGACATCCGGGCTTTTAACAGCCATGCTTTTCCAGGGAGCCCTGTGCA


CTTCATAGATTACACCGTTAGTCCTCACAGTTGTTCCCGGAGGTAGGTAGGATCAGACAGAGCACCTAGGGGTGAGAACAGAGGGCT


GGGGCGAGTCAGTCTGAGAAAAGCAGTGGGTTACTTCTTTTATGTTAGCATTTCTGCTTTAGGCAGAGTTCTGCATTTCCACCTATT


TTCATATTTTCTTCAAAGCATTTTTCAAATGATAAGTCATTAGCTTCATGGCTGCAGAATGAAGTAAGGGGATATTAATATAGCTAT


TGAGAAATAAGAACCTTCACTGAAATATTTTTAGGGTCGTTAAGAGCAGTTTTAACTCTTGGTTTGGGTGTGATTTTTGCCTAGAAT


TTGGAGTGTATTTAAATTGATTTTATATCTAAATTGAGTGATCAAAAGAAACCTCTCTAATGATATAGTTGTCTAATGTCTATTCAG


TGTAACTCTTTGAAGGTGCAAGATTAATATTCCTAAAGCCCAGCTCTGATCATTTCATAATTTTCTTTTGTGTCCTTTTTAACATTA


TGAGCTTTGGATTCAAAAGACCTGGCTTCATTTTATGGGCTGGTTATATAACCTGTCTGATTCTCACTTGCCTCCTCTATAATGGAG


GTAATAATACCCAACTCAAAGAGTGGTGGTTACAATTAAGTGAGATCATGTGTGTGAGATACTAAGCACAGTCGATGTCAATAAAGC


TTTAAAAAGGCAAAAAACAGTACAAAATCCAGATTCTTTGATGCTATGTTTTAGATGCTGCCTTGGAATCACCTCATAACTGAGTTC


TTATTTTCCAGCCAAATACAAAACCTCACTCTTCATTTTTCATGAAGCAGAACAACCAATACAATTTACATGAGGCTAAAAAGCTTC


ATGAAATAGTACTTTATCTTGCCACATGCTATAGCATTCTATTCCATTTCATTGAGGAAGAAAATGGCCATTAAACTGTGATATCAA


GCAAGTTGCAACCTGTTTAAAAAACAGTGGTCTAGAAGGCCTTCCATCTCCATTTCTTAGAATTCTATCCTCCACCCCCCTTGAGAC


CTGTACCCCCTCATGAAATCTTCCCTCATCTTGGCATCTGGTGGCCTTCTCTGAACTTATTTTTTCTCAGTCTCATTTATGGCATTT


ACTGCAAATTGGCATTTAGGTTCATTATTGATTCATAACTTATCTCTATGGTGAGATGATAAGTACCATCAGGGCATGAACTCCATT


GTGCCATCATTTATCAACCTGTGAACATAGCAAGATGTCCTGCCCACTGAAGCCCTCAGAGGTATTTGTTAGGAAATTGCCTGGTGT


CTTGGATGCTTCCTTACCTTTGTGCTGACATTTGAAAGCCGTAGAATTAGAGTTTGTGTGTTTACCCTTGGGAGCGGGTTGCCTCTC


GCCATGACTACTATCTAGTTCAGATGTTTTCACCTGGCCTGCCTTGGATTTCTTGTGTATGTGAAAAAGAATGACATTAGGTTGAGA


TTGGTATTCTGGCTTCTAAATGGAGATTCTCAATTTTCCTGTTTCCTGACTTGACTTTGTTGGGCCTCAGAGGTTCCTTTCAGTTCT


AACGGTGTTTGAGCAAAAATCAGCCTCCTTTCTGATGAGACCCAGCCTGATATCTTTAAACCTTGGACCTTTGCAGCATGTAACAGT


TAATGATTTTAGCCTATGAGACCTGCACTTTATAGCCTAGGACACCTTTGATGTTTCTGTGTATGTACACGGTGATCTGTAGATTCT


ATATGTGAGTATATTTATATGCAGTATTTTATTCATATAGAGCCTTTCATCTACAATGAGAAAATAGTATACAGACAAGAATGGAAT


ACTTATATCTTAATTATACAGATACAGTAAGTCCTCACTTAAGATCATCTATTTGGAAACTGTGACTTTAAGCAAAATGACATGTAT


GTATAAGAAATCTAATTTTACCATAGGCTACTTGATACAGACAAAAGTTGAAGTTGCTAGGACATATTTCTGGTCACAAAAACATCA


GCAAACTAAGTAAAGATTCAAAACACTTTTAATATTAAACATTGAAATAAATGTGAGCTATATATACAGAACTCAGGAGGTGGAGGT


TGCAGTGAGCCGAGATCTCACCACTGCACTCCAGCCTGGGGGACAGAGCAAGACTCTGTCTCGAAAACAAGAGAAAGGATTAATAAA


AACAAAATAATTATTTACTCAATGATTCCATGATTTTAGTTCAGGGTTGAGAGTGGCTGGAGTCTGTCCTGGCATATCAGGGCACAA


GGCAGGGACCCACCCTAGACAGGACACCATTCCATCACACATCCACACTCACTCAGACAGGGACCGTGTGGACACTTCAGTTCGGTT


CACCTAATGCACACATCTTTGGGATGTGGGAGGAAACCAGAGTACCCAAAGAAAACCCATGCAGACGTGGGGCAAATGTGCAAACTC


TGCACAATGGCCCCGGCCTCTCATCAATGTTACTGAAGGAAACGACATTGAACAAAATGACATTTCTCGAAGACCTGCTGTACACCA


CATCTCACATTTGGAGCCCAGTTTTGAGAACCTAGTGATAAGATTTTAGGAAGAGCAGGACCCATTTTATGTTTACACAAATTACCT


ACTCAAGGGTCAACCTCATTTAAAGGAACTGATTTAATTTAGGAAAGCTGTTTCTTTCCCTTTTAAATCTAATTTAAGAAGCTTGAC


TGAAATAGTAATAGATACCAGAGAAGTGACTGTGCAGCTACGTAAACTAACAGACCTGGCCATAGAAACATCTCTCTTGGGACAATA


CCTTGATAAAATACATATCAGAAATATCTAGGAAATTATAGATAAAAAACAGATCATTAACAATTTAATGACACACAGTAAAAAGAT


TTTTAAAAACATAACTGCATAGTAAAGTCTGGGAAAAGTTACTGACTGGTACACAGGTGTAGGCAGTAAATCTATTCATAGTCAGAT


TTTTCTCTTTTGAGCATTGAACAGTTAATAGGGACTTATGAAATGAGTTTTGTTAATTCAGTACTCAGAATTCTCAGACAAGCTTCC


TTATTTAGATTCTTTCCCATCTAGTCTGCCATTTACCAGAGCTAAAGTGTGTGTCAAAGGAAGCAGGATTTATCTTAAAGGAGATTT


GGAGGAAATCTTCCTTCAATATTTAAGTGTTTGACAAAGTCATGCTCACATGGACGTCAGTTTTAAGAGGAGGAAGTTTAAAATCAG


GTGGCTTATTTACGTTACTGGCTGAAAGCCTGTCTGATAGGATTGACATGGAGCACTAATTAATCACCTAGGGTCTCCTCATTTACT


AATCATATTGCACAAAACTTCCCTGCTGACTGAGGCTCAAGGGCAAACTGTGGGCTTCCAGCCAGCTTATTTTTCATAAGCATTATG


CTACCACTGTAAATTAATGTGAACCTAATATATTCTGTCAGCGGTTTACTTTCCCATGGCGACCCTCTCTGGTTAAACAGCTTTAAA


TGAAATCTTGTATCAAAAATGAAAAGAAGTTTCTTGCAAAAGGAAAAAAGGATTTTAGGTCCTCTTTGCAATCTTTTTTCCCCATAG


TATATGCTATTTCGGTTCTGATACAAATCTGCTAGATTAACTGAATAATGCACAGATGATGTGATAGTTTCTTTTTGTTATCTGAAA


AGTGACCTTATATTGTGCTTAGGTAAGAGACTTTTTAATTACACTTTTAATGGCAATAATAGTGTGTTTATTGAGTGCCTACTATAC


ATAAACACATACCTTAACTCATTGATCCTCATATCAATGCTATGTGAATGCTAGGCAATAGTCTGTATTTATGGGAGAGAAAAATTG


AGAGTGTCAGCTTGCCCAGGCCACATCCATTAAATGCTGGGGCCCAGATTTGAACCAAGGTTTGTCATCAGAGGTCAGGCTCATTTG


GCTGTGTCACTATTTATAATTTGTATGGTCCCTTTATACTTTCTGTTTTAACTTCAGGAAATTAGCAGTCCTCTTAATTTTTAAAGA


TAAAAGCTGGGCACGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTCGATCACTTGAGGCCAAGAGTTCATG


TTGACCAGCCTGGCCAACATGGCGAAACCTTGTCTCTACTAAAAAATACAAAAATTAGCCAGGTGTGGTGGTGCACACCTGTAATCC


CAGCTATTCAAGAGGCTGAGGCAAAAGAATCACTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAGCACGCGCCTCTGCACTCCA


GCCTGGGCAACAGACGGAGACTCTGTCTCAAAAAAAAACCATAATTTTTATTTCCATGTTGATTTTTTAATATTCATCTGAATTAGT


AAATCATTTTAGAAGCTTGCTGATCTCTAGCACATGCTTTTATATCTTCAACTCACTTTAATGTCATGCCACTTTTATTCAGAGAAC


AAAAAGTTATGGATGTCTTTAAACCAGAGGAAATAAGGGACCCTTATTCACATCCCTCATGCTGTTGTTCATCAGGAGACTCTTCCA


AACAATTCTAACAGAAAAGGAAAATTCCAGAGTGCACACACATGGATAGTTTCCAAGGCAGTGCTTGTTGAGAACCCAGCCTTCTCT


CCTGAAGCTGTGAATAGTTTGTCTTATATGTAAATTAATTTCCAAGAGTCTGTGCATTAAAGTCTTATATAAAAGAACATATAAAAG


AATGATTTGTCAAAACCCATTTTCCTTGTAAAAAATACCTAACTAAGGAGAGAGGATGATATTCGGTGGCTTCTGTGGGCTCTGTGT


TAAGCCAGTACTTTACTTCTTAGTATGCAGTGCTGATGTTCTTGGTTGAAAGGAATCCATTCCATTTCTTTTTATAGTATCATGAAA


AGTTGGAAAGAGGAAAAACTGAGCTGAACATACAGAATAAATAACTAAATGGTGTCGTCAGGCTGCCCTTTTGTTTTCAGACATCCC


CCCTCCTTCCTCCTTTGTGAGTCACTGAGCCAGTAAGATGGATCAAAGATGCCTCAGTGTATAGAACATTTTATGTGGAGGTTATTT


GTCATCCACAACAAAGGACTAATTGCCTCTGTGCCTTCTTTCACATGATAATCAATGGATTGGGATCTCCTGATTATGCCCCATGCA


TCCTGCATTCATCTCTCAAGATGTTTTAGGTTTTGATTGAATTTATAAAGCATCAGAAAGATGACGTCAGTTCAGTGCAACTATTAA


GGGGATTTTAAACATGGGTATGGAAATATGAAAACAGAGCTTGAAGTGAAGGCACCTGTCATCATTCTTTTTGTAAATGGTTGATTT


GATCGGAGGTATAACTTCTATGATAGCTATTAAGAAGGGTCCTGGCATTTTTAAGATGGAGCGTTTATTTCAAAAGGCCCACCAGGA


GAAAATTCACTTCCTGTTTCAGCGTGGACTTGAGGTTCTCAGAGATGACTTCTTGGATGACTTTGTTGCTAATGTTATCAATCAGGT


TTCATTTTAAAGAAGCTTTCTGAATTCTAACAAGAAGTCAGTGTACTCTGAGTATAGTTTTCTGTAGTGGATTTGCCTAATGTGGGG


GTTGGGCACATAGGCCACGGGAGCGTGTAAGTGTAGGAAACACCATTCAGCTCATTCTGTACAATGTCTGAAGCTTTGAAGTTACAT


TCTCCTGGCATTTCAATTATTTCAAAGGCAAGATGTTTACTAAAATGTACCTGAAACATGGAGTTATTTCTTAGGAACTTTTAATAT


TTACAGTTAAATTAGAACACTTTAAAATGAAAGAATGATATATTGACTGTAGCACAGACATCTGTTTAATAACAGTCACTTTTCCTC


TCTTTAAATGTATAAATGTCCTGTGTTTCTTAGAAAAGAAAGATTTCATCAGTGAAACAAACAAAAAAAACAGAACCCACAAAAACA


AAATAAAATTCAAAAACACACACAGATATATAGGCATAGAGAGAGCATTTGTGATAAGTGTTTTAAAAATAGCTATTAATATCTCAG


CAGCCTCCTCAGCTCTGATGGTGCTGACATCCCACAGGGCAAGCTGAAGCAAGCCAGGGGGCTGGAGAACAATCTAAGACACCAAAC


TCTTCTGTGGAACAATAACACTGAGTGTCAAGGACTGTGAAGGGTCTGAGATTTCACCCTGCATGCCAGCAAACAAGTTATCCTGCC


ACAGTGTCACAAATCCTGGCAGAAGGCATCACACTGCTGGGGCAGACACATAGGACTTTATTAATCACAGCAATGCCAGGAACCAGA


GGATCAATATTTTTGTACACTTTCCCTGAGCCCTAATTCTTACAGGGTGGTGCAGAGAGGGCCAGGTGATACATAGTGAGTTGTATT


CTAGGAGAGGAACCCTGAACTTAGGGAACTCCGATCTTTTATAATGGGCAGTAAGTCTCCCTGACCCTTGCTCTGTAAAGAAACACT


GAATCTTTCAAGCCTATCTGCTGTTCAAATTTTCTTGAAAAGATAGTAACGAAGGACTCACTTGTAATGTCAGTGCCTTGCTGATAA


GGTGGCTCACACCTGTAATCTAGTGCTTTGGGAAGCCGAGGCAGGTGGATCACGAAGTCAGGAGTTCAAGACCCGCCTGACCAACAA


TGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGCACGCACCTGTAATCCCAGCTACTCAGGAGGCTGAG


GCAGGAGAATCGCTTGAACCGGGGAGGTGGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGACACAGCGAGA


CTCTATCCCCCCCACCCTGCCCCCCAAAAAAGTGTAGATGTGAGAATTGTCTCCCCACACAAACTCTTCTGGAAATAGGCACCAGAT


AAGTACCGATTCCATGAATGGCTAATCTGTGCTGCCTTCTAAAGGCAGTGCAGGTACCAGATGACACAGCCATAACTGCAGCGTTAT


ATCTCTGTTATTTTAAGAAATGGATAAAAGGTGGTATTTTAATTTATCCTGTATCTATGCAACATATTCTTTTCCAAATGTCTTCCC


TGTGTTTGACAGTCACAGTCTTGTGACATTGCAGCAGGTGTTATTACCCATTTACACTTGAGGAGACTATCATTCAGTGACTTGACC


AAGGTCACACACAGTTACTCTGCAGCTCGCCACTACACCTGGGGGCTCCTGACTCCCCGTCTGATGGTCTTTGGAACACATTGTGTA


ACACTGCCTCCCTTTTGTCTCCTACGTAAGGTAACGGATATTTCCAGATATTACAGAGGTGCCCCCAGGCCAGTCCTGAGTTCCTTT


TTGGCAGTTTCCGTGCCTCCCAACTCATCTTACCTAGCCACACAATGCCCAGTGTCTGGTGGTCATGCTGGACTCATTTGAGTTGAG


GGAAGTTACTTTTTTAATGCTTTCTTGTTGCTCTATGTTTTAATTTTCACTTAACGGAACACAAACAGTCTCCACTGTTGCCACCCC


TTTGCTTAGTAGAGCTGGCCCCTTCCCCTACTTAATGTGTAATTGCTCTATGGGCTTTGGTGGCACCTCTTTCTTGGTTTCCTGCTG


CCCTTTTATCTAATTCTTCTGAATCTCCCCTTTTGGTCCCCTCTGTACACTGCCCCATACATCTTCATGCTCTCTAAGACAATGCCT


TGATCCTCTTTCCTCCAGACTATATGTAGCCTTAATGATAACCACAGTCAGTTATTTATTGAGCCAGGCATATGCCAGGCACCTTTT


CATGTGCCACACACTTTAAGCACGTTATTTGAGCACATGCGTTATCTCATTTAGTCTTCCCAATGACCCCACGAGATAGATTCCACT


TGTCTCTGTGTTTTGTAGAGGAAGAAGTAGAGGACTGACAAGTTAAATTACTTGTCTGAGGTCACACAGCCAGTAATGGTGGAACCT


GAATGCTAAGCTAAGTTTGACTCTAGAGCCAACTGCTGTCCAGCCCCCAGATTTCCTTGTGCAAGAGTCAGAATCTTTCCACATCAG


TGTCTGACATCTGTCTTGGTAATAACGCCTAAAACTGAAATCTAAAACTGATATTTCTCTCCAAATATTCTCCACTTCTAGTATTCC


TAACTTTGTAAATGACACCAAAAGCCTGCCAAGTTGTTTAAGCTAAAAACTGGGACGTTTTCTTAGACTGCACTCTTTTCTTCACCT


CCCAGGACATTCCCCTTCATCCATTCATTTTTTTCCTTGCCTTTCCTCTTGTTTTTCCTTTCCTTTCCTTTCTAACAGACTCGCTGT


CTCACTCAGGCTAGAATGCAGTGACGTGATCATACCTCAATGTAACCTTGAACTCCTGGGCTCAAGCGATCCTCCCACTCAGCCTCC


CAAGTAGCTGTGACCACAGACACATACCACCATGCCCGGCTAATCTTTTTAATTTTATTTTCATATTTATTTTTTATATTCACTGTG


TTGCCCAGGCTGGTCTCAAACTCCTGGACTCAAGCAATCCTCCCACATTGGCCTCCCAAAGTGCTGGGACTACAGACTGAGCCATTG


CACCTGGACCTAAAGGCCCATAATTTTAACCTTGTACCCTGCTGCTTCCTGCCACTGAGTCCATAGAGTCTCTGCCTTTTCATCTGC


TGTCTCCATCTTGCTGCGGCTGCCTCTTCCTTTTTCAGCTGATGTCATTCTCACCAAATTAGTAGCCTCCCAATTTGTCTTGCTACC


TGCAGTCTCATCTCTCTTCAATTCATTCTTTGTACTGTGCTGGAAAGATGTTTCTGAAATGCAAATCTGATAACTTGTTTTGCTTAA


AATCCTTGGTTGGCTTCCCATGGCTTGCTGGTCCCTTGGTACCCATAACACATACAGCTATGCTGATCAGGCCTTAACCCTTCTAGC


CCAGAGGTTCTCAAACTTCAACACATGTCACAATTACCTGCAGGGCTTGTTAAGAAGACAGAACTTGCTGGGCCCTGCCCCCAGAGT


TTCTGATGTAGTAGGTCTCGAGCTGCCTCAGAATTTGCATTTCTGACAAGTTCCCTGGTGCTACCACTGGTGCGGGACCATAGCCTG


CCTAGTGCCTTGTCTGGCTCTCTCTGCTCCAGCCCTGGAACCACTTGCAGGTTCCTGAAGGGAGATGCTGTTTCAGGCTTTGATCCT


TTTGGATAAGCTGTTGCCTCTACAGGAGATAGTCTTTCTATCGCCGTCTCTTTAAAATACAGTTCAAGTGTCACTTCCTAGGAAGCT


TCCTCTGACCCCTGCAGTGATCTCATAGTTTCTGTGGCAACCCATGTGCATCTCTGGGAATGCTCCATTTCTGTAATTGAGTTGTCA


TTTTATTTATGTATCTCCCACCCACTCCCACCAGACCATTAGCTCTTTAAGAAAAGATATCATTCATTTTCTTTTTCACCCTTCTAT


CCCTGGCACCTAGCATGGTGGCTGGTATATACTGAAGATATTCATTAAATAAGTTGAATGATATAATCCTACTTTTACCTTAAAGAA


TAATTCTATTTTGGTTTTTATTTGCATTAACCTTTATCATACCTTGTTTTTAAATGTCAGGATAGACTGGGTGTGGTGTGGCTCACG


CCTGTAATCCCAGCACTTTTGGAGGCTAAAGGGGGGAGGATCACTTGAGCCTAGGAAAAAAAAAAAAAGTTAAAAAAAAAGTCAAGA


TGTTTCAACATAAAAACAGTGTGCATCTGACAGTATTAAACTTTCGAAGCTACCATTAGAGAGAGCTTATAACTCAGCTGTCTAATG


CAAACCGCAGTTTATTCCTACAAAGGCTGATGTTTGTCTATAGATAACTTACTTCTCATGCCTCTGATTTGAAGTGCTTGAGTTATT


CCTCAGTCTTTCTCAGCCTTCAGAACATTTCTCTGGTATGTTTTTCAGCCTTGGATTTATCTAATCAGGGAGTTACAGATGGAATAG


TGCAAGCCTTTCTTTTACTGAGACAAGCAAAGATTAGTGGGCTGTAAACTTGCAGCCTCCATGTTTCCATCCAAAAGAGGATGGCTC


ATCCCTCACTTTCCCTTTTACGTGCCTGCATTGCTTGGGTAATTTCCAAGAAGAGTATCAGTTTGATTGCTTGCACAGCCCTCCCTT


CTCTCCCCTCCCCATCTCAGATGACTAGTCCTTGCCAAAATGTCAAGTTCCAAACCCTAACAAAAGAGTTTGCAAACAAGACTGTCC


CTGGATTGTAGACATTTCTTCAAGGGGTGCCTGGCCTTCTCCTGGTGTAGTGCAAGTTCAAAGGCAAAGAGCCCTTTCATCCTCTGG


GAAAACAGAGAACACAGTTCCAAAAATGCTTGGATACCTCCAAATAGACCTCCTCCCCTGCCTCACCCCTTTCCCAGGCTCTGCTAT


GTGGTGTTTTTCAGGAACCATTCTGTGGATTTTAGCCATATCATTCTGCTTCCATAGTTCAACAAGCAAGCAGCAGACAGCTCTTTC


CTGCAGTGGATGTGTGGCTGAATTATATATTCCTTACACAGCAAGTAACAACATCTTGCCCAGTAGTTCAGAACAACTGGTAATCTC


CATTCAATTATTTGGAAAGAAATTTCCCTCTGCCAGAGCATGATTAGTCTCTGAGCACCATCAGTCTCATGCCTGTTTTGCATATCT


TGTAGCTTACTGTAAGCTTGTCACAGGATTAAAGCATGAAAGCAATTGATCTGGTCTCTTATTTATGTCTTAGGACCAGTCTTAATC


TGTTTTGTGGTGTTGCTACAATAGAATACCCGAGACTGGGTGATTTATAAAGAAGAGACATTTACTTAGCTCATGGTTCTGCAGGCT


GGGAAGTTCAAGGGCATGGCCCTGGTTTCTGGCAAGGGCTTCCATGCTGCATCATAACATGGTGAGATGCACAAAGGGGAGACAGAC


ACGTGCAAAGAGGGATCAAACAGGAGAAGGAATCTCACTAAATGCCAACCAACTCTTGTGGGAAATAATTCATTCCCAGAGAACTAA


TCCAGTCTCAGGAGAGCAAGAACTCACTACTGTTAATACAAGTGTTCAGTTACCTCTAGAACAGCTGCAAGCCATTCATGAGAGCTC


TGCCCCCATGACCCAAACACCTCCCACTAAGCCCCACCTTCTGACACCACCACATTGGGGATCAAATTTCAACATTCATTTTGGTGA


GGGCAGACAAACCGTGCTCAAACCATAGCAGAATGCTTTTGGCTGCATGTAACAGAATGCCCCCAAAGTAGCTTTACCTAAGATGAG


AGGCGCTTACTTAAAATAGGAGCCCAGGGGATTGCATGGAACCCAGCATAAGGAGTGCAACCACAGGTCCCGGGATAAGAAGCTGGA


AGCAGTCAGGAACATAAGCTACTCTGGGTCTCTTTTCTACTTTCTATATCTACATAATATCCCCCAGTCTATTCTAGCATGAGGGAG


ACTAGGCTGAGAAAAATCACTTTGTCCAATACCAGACTCTTGGGAAATGGGAGACTCTGGCCCAGCCTGGTATTCAGTGGAACAGCT


CTTCCTGAGTCATATGTCTGACCCTAGTGACTCATCTGTCCAGAGAGTGGGAGAAGGCCCATCCTCCACAAATATGCGTACAGGAGC


CCCTGTTGGGGCAGGGCCAGTTTTCAGAAAGGGGGATGTAGATGGAGGAGCTAACTCGATTAATATTGGTTATCATTTGTATCCCAC


GTTCTTCTGAAAGGATTCTGTAAAAAAATAGGCACAATGAAACCAAACCCATTCACACAGGATATCATGCAAAAACCAGGAGCAATA


AGGTTACGGAGAGGAAAGATGCATCTAGAAGCCCTGATGGAGAGAAACTTCTTTAATGCAGAAATTAAATTAATCAAAATTAGTGGA


TTTAAAAGTTCTGGGGCTAGTCATCCAGAATTCATGAACTAGGTTGCTAAGAAAAGCAATGGAAAAGATGTGAAATTAAGTACCATA


TGAGTATCTGACTAGAGTGTGTTAGTTTGTTTTAAATGCATGGGATACTGTATACATTTTTTCCTGGAATGACCCTCAAGCTGAAAT


TGAGGAGAGAAGATAAATGGGAGGCCGGATGCTGCCACTTCCTGTGAGCACATGCTCTCTGGTTAGGACAGGCCCCATCACTGATCT


CTCTTATCTAATCCCAGGTCACATCACTCCTCCATAATCCTCTGTGTTTGGGTGTGTGTGTGTGTAAATGTCAAATAAGGGCACATG


CAGCAAGTGATACAGAAGTTCAGGAGAGGGAGAGAGAGAGAGAGAGAGAGAGCCTCTGATCACTGTGAACTAGTATATTTTCTTGTA


TTTGGAGGAGGCAGGACGTGAAGCTGCATTTCATTTTGACCAGTTGTAGATGGCAGGGTTGGAGGGGCAGGTTGAGAAATGTGTCAG


GAGGGGGGCAGGAACTGATATTAATGACAATACTTGCCAAGCACTCAGTGCTCACGTGGTCACATCAACACACACAATTGCTTTGTG


CAGTTCTGAGGTGCCCTTCTTATCTGCATGTGACAGGTAAGGACACCAGAGCTCTAAGAAGTCAAGAAACCCTCCAGTGATTCTTTG


TCTCAGGAGAAACCAGAGTCCTCACCACAGCCTGCAAAGCCCAACACAACCTGGCTCCTATCATCCTCTGTGCTGTGTCTTGCAGCC


ACTTGGTGGCTGTGCCTCCAGACTTTCCCTGGAATGCTGTTCCCCCGACACCTGCCATTCACTCCTTCACCTCTTTTGTGTTTTTGC


TTATATGTCACTTTCTTAGTGAAGACCTCTGTTATTTGCTCTGCTTTCATATTGCAGTGCCTCCTCTGTCTTCTGCCACATGACAAG


CCCGTGACACTGATCTCTTTCCACAGCACTTCCCATTTTAAAAAATTCCCTGCATCTACTCACTTATGTTTCTTTATATTGCCTTTC


TCTTCCTGCACACTTCAACTAGAATCTAAACCCCACAAGACCAGTCACTTTGTTTTGTTTCCCACTTTATCCAAAGCCCCTAGATGA


CCTCCTTGCTCATGGTAGGTGCTCAATAAATATTTGCCAAATGAATGAAGACCCTTTCCCAAGATCATGAAACTACGTAGCACTGGA


GTCAGGGTTCAGCAGGCAGAGTGCACTCGGGCCACACTGAAAGGAGGCCATCAGGATGAAGTGACATGAGAGATGGTGACCCTGGCT


GGATGGGACATGTCCTGTTTACAGTTTGAGCTTTATCAGTCACGCCATCTTACCATGAGGACTCCGGACAGTTTGAATGTACAAACT


GGGACACGGGGACCCAATGGGAAAACTGGGATTGACTTTCTGCATATTGAATTTTCCACCAGCCCACAGTTACTCCTTTGACATGGC


CAGAATTATCCCCAGAGGTTTTTTTATTCCTGAAATAAGTCCCTCCTCTATAAAGACATTTATTTTGTTATTATAAGTATTTAGCAC


ATTTGTGTGGACCCTGCTAAAACGAGTGTTGTTCAGACTAAAGTGTCAGAAAATATATAATACAGAGTACAGGTGCTGCAGCTTCAG


GAAAATACAACTTTCCTAATGGCACTTCTCCCCTTGCCTCCCTTCTATGCTAAATTTTTAAATGCATTTCTCCTGTTTATTCAGGCA


GGGATTAACATTTTCTTAAAGACTTCATCAGAATGTTGGGTTTTTTTCCATTCATTGTTATTTAGGATGATATTTTTGTGACTCCAA


TTTAGGAAAGAAGATTGACTTGATCTTTATTTTCCTCTATCATATTTACCTTGTGTGCTGTTATTTTGAGTCTGTTCACAGGATCCT


GGGCAGATGCCATCAATGTAATTGCTATGTTTTTAAGCAAAGAGGATTGAAAGTGTCAATTTAAGAATTGTCTAGGAACTTGATATA


TACTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATTTGCTTTTTATGAATAAAAGTAGCAGGGGTGTTGGAA


ATATATGTATATTTTTAAATAATTTATTTTTTAAAAGTATACAAACCGAAATTTATTTCAAAGAGAATTCAGATAGCAGCCAAAATA


CACAGAAAAGAAAACTGTCCTTCAGAAGTGCCACTAGATCAAGCTAGTTATGAAATTGGCACCTGAGAATAACTTCTGTCAGAGGGG


ATGTAAGTCTTTGGAATTTTGAAGAGCCATAGTCTCTGTAGAAGATGCCAGAAATGTAGGCATTATCCTTAACACTTCCTTTTCCTT


CCCCTTCCTCCCACCCCCACTGAAAATGTCAGTTTTACTTCTCAGTAGCTCTCAATTCCGACCGTTTCACCGTATTTCAGCCCAGGA


CATGATCACATCTTGCCTGTATTACCAAAGTCACCTCCTTTTGATCACTGTAGATGCACTCAGACTCTAATCTTTTCTGCGGCCCAG


ATCCTCATTTTTCCAAAGCCCAGATCTGCAAAGACCTGCCTGCCTACCCCACCCCTGCTCACCACACATAGCTGGCCTTTAAATGGC


TTCCTGGCACTTGTAGGAGAATGACTGGATTCCTTAAGGTGGGCTACAAGGCCTGCATGGGCTGGTCCATGCTCGTGTCTCTAATTG


CAAACCTGCTGTACCTTCCCCACTTCCCCCATTCTCTGTGCACCAGCCACAGCAATTGCCTTTTAGACCTGTTTACTTGTCATGCTT


CTCTCTCTACTGGGACTTTGTACATTCTGCTCTGCCTGAAACACTCTTCCTCCTTTCTTTGCTCATTAACTCCTTCTCATCCTTTGG


ACTACATGTACGCATTTCTCACTCAGGGAAACCTTCAGATGCCCCTCCAGGTCAAATCCCCCTGTTATAGTTTCTTTGGCCTTATTT


GTTTCTCCTTTGTAGCACCATTAGGAATGATTTTACGTTTTACTCTTTATTTGAGGACTCTCTCTCTCTCTTACTGGACTGTATGCT


CATTGGAGGCAGGAACTGTTTCTGTTTTCTTACCTTCATTTATCCCAAGAGAAAAGTAGTGTCTAGTACAAAATAGGAACTCAAGAA


TATTTGTTGCAGATTATAAATGAATGGATGAATGGCCTCTTGAAGTATCCATTTTTATACCACTTAGAATAAGGCACTGTACCAATT


TCAAAATGTTGGAGGTTCAGCAAGGAAGAAAACCACCAGATAGGGAGGAAAGGATCTTCCTTTTGTAGAATTCAGAGAAAAGTGGGG


CAGATGTGTCCCTCCAGAGGTAACTAATCGCCCTCATCACATGCTGGGGCCATTTTCTTCTCCAGCTGTTCCCAAGGGTCAGCTCTG


CCGGCTGTCCTTCTGCTATGCCTGAAGGCTTCCATCAGCCTGCCTGAGGGCTGTTCTCATTCCTAGGTGGGAAAACATACCTTTGAT


GCCTAGAAATTAAAAGAGTAATTTAGAGACTTAGGGCATGAGTTTCATTACAGTTCTCCGTCCCTGAGCTTGCTCTGTGGACAAACA


TTCTGTGCATATTAGGAAAGTATAATAGTTTTGGTCTTGGGCTAAGGATTCAGATTTTCTGAGCAATGTAGCTCAGGCACCTTTATG


ATCTTGGGAGGAATACTTAAAATTTCTTTTTTTTTTCTTTTTTGTTTGAGACGGAGTCTTGCTCTGTCGCCAGGCTGTAGTGCAGTG


GCGCGATCTCAGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGTG


TGCACCACCACGTCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTTACCATGTTGCCCAGGATGGTCTCGATCTCTTGACCT


CATGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAACCCCTGCACCTGGCCTTAAAATTTCTAAGCCTCAGTT


TCCTTATCTATAAAATGGGGATTAAAACAATATCTAGTGCCTGGGATATTGTTATGGGATACTTTGTACCAACATTATTCTATAAAA


ATATAATGCAAACCACCTATGTAGTTTACGTTTTCCATAGCTATCTTTAAAAAGTGAAATGAAATTAATTTAAATATTTGACCCAGT


ATATCCAAAATGTTATCACGTCAAGATGTAATCGATAATAAATATTAATGAGATATTTTACATTCCTTTTATTCATATTAAGTTTTC


AAAATTCAGCCTGCACTTTACACTTACCAGTGCAGCTCAGTTTGAAACAGTAGTCATGTGCCATATAATGATGTTTCAGTTAACAGC


CAACTGCATATACAATGGTGGTCCCATAAGATTATTATATTGTGTTTTTACTATGCCTTTTCTATGTTTAGATACGTTTGGATGCCA


GATACTTACCATTGTATTACAGTTGCCTACAGTATTCAGTACAGTGACATGCAGTATAGGTTTGTAGCCTAGGAGCAATAGGCTATA


CCATATAGCCTAGGTGCGTCATAGGCTGTACCATCTAGGCTTGTGTAAGTACACTATGATGTTTGCATGACTACACATTTCTCAGAA


CGTATTCCCTTTATTAAGCAACACGTGGCTGTAGTTTAGCCATACTTAGCATTCAACAAATGCCGGCAAAATTATTGTTATTTATTT


TAAAACATCAAAATTTGGGTTGACAAACATTTGTACTGTACATTTGCATATATTGCCATGTGGGAAGATGCCTCAGATAAGATGCCT


CAGATATATTTTTTTCCATTTCAAAAGAGTAAAGGGTTGACTTTAAGACTTCTCAGCTATTTCCTGCAAGTGGGCCTCCCTGGGTTT


CAGAATGAGGTCAGTTTCGTGGTTTATGGTTGTCTTTTCTTTGGGAGGTGGGAAGGGGAAACTGAATGTGCCTCAAGTATTGCATGC


CTGTCTCTGTTTTTTGGCTCTTCTCTGTTTAATTATTGGGAACTGGAACAACTTGATTTTAAAACAAAACATATGGTCTGAGAATAA


TTGGGAGGACATTTGCTAGTGATGTAGCACTGAAGGTATGTATCAAGTTGAGGCCCAGGCTTGCACCACTTGCTTGCTTAGGTATTG


AGTGTTTCCCTTAACTTCAAATTGTGTTCTTTCCCAGTTCTTAAACCCTTGTTTGGAAAGTCACAGTCAAAGCAGGAAATATGGGAG


CAAGATTATAAAGGAAATTGTCTGTGAGTCTTCTTTAAATCCCTACTTTTTTTCTCTCTCCTCTTTATGGAAAACCATTGGTTTCCA


AGCTATTTATATGGCTCGTGAATGAAAAAAGTTGTCTCAAAGTGCCAAGAGGAGAGACGAAAACTTTATTTAAAAAGGAGAATGTGG


ACCCACCATTGAATTTCTCTGTTCTTTTGCTTAACTCCATTGTGGACACCAAAGTGGGGAATTTCTGTTCCACAGCCAGTTCTTATG


TGAAGGCAAGGTTTTTATCTCTCTTTACCTTTTCCACACCCCTTTGCTTGCTGGGGGAGGAATATATGATATGCTGATCATGTACCA


TGTAATTCCAGCCTGAATGCCTCAACTTTTTATATCATGGGAGCAAAGGGGAATTTATCAGGACTGCTAAGAACATGTATTTCTCTT


GTTCAAGTCTCTGCTCCTCTGCTTAGAAGCTATGTGCCTCTGAGCAAGTTATTTAAACTCTCTAAACCTCATTTTCCTCTTTCCTAA


AAAGGGGATAATAAGAGCGCCTATTTCAGAGTAAAATTGTTGTGAAGCTTTAAAGAGACATTGCACACAAAGCACTAAGCATGATGC


CTGGAAAGTAATAAAAACAAATCTTAGCGATCAAGCAGAGGCCTTCGGCAGGAACATGTCCACACCATCAGCAGCAGGAGCGACAGT


GAATACTGCGTCAGGGAAAATAACCAAACATTTGTCCATGAGGAGCTTCAGCATTGGAAAGTCAGCCATTTCACTGGGTTGTGTTTG


ATGTCAATGGGTTGAAGTCAAAGCCTTAACTCTGTGCTTCTGTGCTTCCTAGGTCTCATGGGAGCCTGTACACTCACTTGTCAGTGG


TCGTTCTCTTTTGCCCAGCACCTATAAATATGAGAGTAACATGCTGAATTGTTTTACTTTTGTGCTACAGAGTCCTAAGTACCTTTG


AGTCTTTTGGAGATTCACTTGTTTTGGATCTGAAATGTAAAATGAAATAGCTCTCTGACCAGGGCTGAGCACGGTTTTTCAGTTGGG


ATAGTAAAACGAGAAATCTTTCTGAACACTTTCCAAGGAGTCCCCTATAAGAGCAAGGGGTAGGAAGAAAGGGGTCTTCAGTTCTTG


CCAAATCAAGGACATGATTTTCTGTATAGGGCTCAGAATGTATTGTGTGTTGTCTTGCTTCAATGTCAGATGAGTGTCGAGAGCTTC


GGGAAGGTCTGCTTTTTAAAAACACCACTATGTTTTCGGAGCAGCTAATTGTCTTTTGTCAGTCCCCTTTTCTTTCTGCTCCTGCCA


TCTGTCCAAGTCCCGTTTGGATTTATTAGTGATTGCTTACAAAGTATCAGGAACTCCCTGCTGAGAACAGTGAAGCCCTTGCCCAGT


GGGCAGGTCTCGGATTTCCCTGGAACTGTAAAAAATAACCACTCTCACTCATTTTTTTCTCTGCATACCCCTCTCAGTGGACCACTT


TCCTCACATTAACTTAATCAAGATGTTAGTAAAATAAACGGTGTGCTGCCATCACACTGAAACTTCTTGTCTCTTTTCAGTGTTTGG


AAAGGAAATTGAGAGTTGCTATTGATAATAAAGATGAAGCATATCTTTACTCATGGCCAATTACACACAGTCCTGATCATTGGATTT


TTAGTGGGTGGACAGCTCTGTACAATGTGTCATCAAGTCTGTGTCGCCCCAGTTACAAAACACTCCATTGTTTTCTATATCAAGGGG


GAAAAAATTATGAGATACCATGGATTTTAAGATACATCCCAATTTCAGATGTGTTCAAATGTGGGGAAAATATATGTATCTTATAGC


AGATGGAATACAGTGAGAATTAATTAAAATGGAAAGCCCTAGTCCGGGAGTGGTGGCTCACACCTATAATCTCAGCATTTTGAGAGG


CCGAGGCGGGAGGATTGCTTGAGCCCAGGAGTGTGAGACTAGCCTGGGCAATATAGTGAGGCCTTGTCTCTACAAATAATTGAAAAA


TTAGCCAGGCATGGTGGCATGCCCCTATGGTCCCAGCTACTTGGAAGGCTGAGGCAGGAGGCTCGGTTAAGCCTGGGTAGTTGAGGC


TGCAGTGAACTGTGATTGAGCCACTGCACTCCAGCCTGTGTGAGAGAGTAAACCCCATCTCAAAAAAAAAAAAAAAAAAAAAGAAAA


ACAGTAAAATGGAAAGCCCTCCTGGTTATCACCTGTTCCTCTCCTGGCATTCCCCCAGTCCTCAACACAGCTAATTGACAGAACGGT


GAGATTTGTGGGTATGTATGAGATGTGCCTCTGCCTTAGGGCTGAATGCGTAACTCAGTCCCATGTGTTGTATACTCTGTGTATGCA


TGAAGTTGTGGAACTGAGTCAAAACCAAGAAGGGTGGTGGGAGGTCCTCTGAACTAAAATTTACACAATCGAAGTTTCTGAAAACAG


AACTTAGGAATTTTCTTTGGGTTACATTGATAAGATTCTTGTTACCTTTGGAAGGCATGATCAAAGAGGGACATCCAAGGCTCTACA


TGCCCCTCGCTGACCTGGCCCATTTGTAATGGCTCAATACTGAAGAGAAGATCCCAGTTCCTCTAAGTTAATGCCTCTGCTTATCCA


TTTTCTAGTGACCACAGGCCTCAGATCCATGGGGAATCCGTTTCCTCCCCTACCCTAAAAGGCAGCATATTAAATGTTATTGATAAT


TTCAGTGTACTCAGGATTCTACCTAATTATTACTCTTCATAATCTGAATGACTTCTAACCAACTGTGTGTCTCCAGCCCTTCTTAAT


GCTGTAAAAATTTTAAGTAGGGGGATTATGGTATTTATTTTCCTGGTAAAGATAAGTGCTCACACTTTAGGAAAAGCTATTTCCCAG


CCAGGTAAAGTGACAAAAGAATTGATTGAAAAGTTTCTTCTTTATATTAGCGGCATTTTCCCTTATATTTACACTGCTTTCTTTCTT


TTTCAGTTTTTGGGAATAACATTTCTTGGAATTGGACTGTGGGCATGGAATGAAAAAGTAAGTTGAATATCATGACAATGCACACAT


CGTGGTTGTTAGAGGCTGCACATCATATTATGTATTATCCCCCTTTCTCTTTGACAACCACAGAGTATAAACATGGCTCTTTAACAA


GAAAAAGTGTTGGTGGAAGATTAATGTCATACTCTCAAAGACACTTTAGGAATTGTGCCTAAATTGATGACTGCATCAAAATAATTA


CTGAAGTAACAATACACGTGCTCAACAGAGAATATACCTTGGAATTTGATCAGTTAGCCAAAGATCGATGTTCCTATGGGATATTTT


CTCACTCAGGCACAAGAATTCCAGTAATGATTATAAATATCACTAAACCACCTGTAGCCTTTTTTTCTCTTCTGCTTTTTTTCTTCA


ACTCTTTGGAAGATAACTCAAGATAAAAACGATTTTTTTTAGTGTGTTATGTGGTAAACAACTATTAGCATGTGGATTGAAGGAAGT


GGGATATAACTTCATGTTTGAGTATCAAATACACTCATCATTAATGTAAATAATGGGAATGTTTGGCTGCTGGTGGCAAGTATTAAG


AAATATTCAGTTTATGATCAAATACAGTATAATAAAAGGAAAATCTGGAAATACAGAGTAATCTATGTGACAGTGAAGATACAATGT


TCTGGGCAGTTTCTGCTCTAAGCAACGCACTCATGCAGACACCCCCTGTGTCCACACCTCTCCTTCCCATCGCACCTTCTAATTTTT


CTCTACAGCTCCCCCTACTGAGGCCACCAGTGGAATTCAACAGTGAATATAAACACCCGCCCCCTCCTCCCAGCTTTTTTCCTTCCT


TCTTTGCAAGTGAAATCACCTGCAGCATTTCATCTATCCTTGTATCTGGCTATACACAAAAGCTTTATTATCTCCCACGTAAGGACA


AGGGGATGTATAGAATGGTTAAAAGCTGCCATAAACTAAAATCTAGCTTAAAATTTCCCAGAAGACCATTCTTTGATCCCGTAGGTG


TTTCACCCTCTAGCCTGACCCTGGCCTGAAGCTGAGAGTTCCTTTGAAGTGGTAAATGCATTAAGAAAGGAGAGAAAAACTGGGAAG


GTCCAGTCAACAAAAGCCCCTCAGAGGCCAGTAGGCATTTCCACAACTAAAACAATGTTCAGACAGACCATATAAAACAAAACTCAA


AGCAAATCCTGAGTTTTGCAAATGAACCATCCTGTATTTATTTACAAAATTCTTCTACAGAATGTAAAATGTTTTATGGAAAACAAA


CTACTTTTTAGCAACAAGAGTAACTGAGGCTACCTGGAGTTTTGAGGCAGGGCAGTGATTATGTATGAGGGGAGACAAATTAAGTTC


CCAAAACAGAGATAATTTCATCTCTAGAAACTTTTACATTGAATATCGGTTGATCTTGTCTTGGATTATGGTTAACTTTTGCCTCAA


GCCTATTGTGAACTTGGAAATTTGTGGAATCTGGGAAGTTGGTTAGATGCCAGATAACACAGCTTTTTATAACTCCTTTAATAAGAG


TCCATTTCTATCTGCTTTGAAAAAATGCTGGAAGGCATTAAATGAACTAATTATCTGTTCTAGCAATAAACAGCAGTTGGTAATTTT


GAAGTTTTTTAATTTTCTCTTTATGAAATATAATTATCTTTTTGTTTCATCAGTTGCCTCAAATGTCTCTTCTCTGATAAAATCACA


AACTTCTAAAACTGGCAGTGTCATACAAATATCCGAGCAAGGGGTTGATGCGGTCTTTAGGGAGGGATGAAATAGCAGTTCCTTTTT


TGTAAGGGCCACCATCAAGATTTCTCTTGAGATCCGAAGTTAACCTGGCCAAGGTCACCCAGCTCCATGTAGCAGAACTCCATAAGC


AGGGAACAAATAGAGGCAGCAGAGGGTGAAGCGGGTGTTAGCCGTGCACCACCCCAGTTTGGTGAGTGCTGGCCATGTGTCTGGGGC


CTGAGTGTGGGGAATACGACAATGAGGGATGCAGAGTCCATGCCTCATGGAGCTTGCATTCTGGTGGGTCACCAATGAGAAGCAGTT


ACTGCCCAAGTATGTTTGTCCAGATACTGGTAAGTTCTGGCAGGAAACATCAAGTTAGAGAGTGGTGGGAAAAGGAGTCTCTTTTAG


ATGAAGTAGTTGCCAACAGCCTCTCTAAGGAGGTGGCATGGGAGCAGAGACCTGGATGAAGGAAGAAGGATCTGCAGGGTATGGGGG


AAGAACATTCTAGGAAGAGGGAAGAGCAAGTGCAGTGGCCCTGAGGCAGGGACTTTGGTGACTCCAGGGAACAACAAGAAGGCCAGT


AGGCCTAGAAGGGAGAAAGCAAGGACAAGAAGAGGTGGGTTGTGTTGCCAGGTAGAGGCCAGACTGGGCAGAGTCCTGCAAGAAGTT


TGGATATATTCTAGGTACAAGGGGAAGCCACTGGAGCATTTTGAAAAGTCTAATATGACTTTTTTTTTAAGATCACTCTGGTTGCTG


GGTGGGAAAAGAGCACAGCTTTGTGGCTTTGCTATGGACTGAATATTTGTGTCTCCCCACCCTGCCAAATTCATATGCTGAGGCCCT


CATCCCCAATGTAATGATATTTGGAGGTGAAGCTTTGGCGGGGAGGTAATTAGGTCATGAGGGCANNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


CACCCAGTTTATGATCAGTGTTATACAGCCGACTAAGACAGGGGTAAACAGACCTGAGTTCAAATACTGGCTCCTCCAGTATTTGAC


ATGTGTGGAATACACACATCTCATCTGTGTGATGTTGGCCAACTGAGTTAACTTCTCTGAGATGCCATTTCCTTGTTTGGCAATAGG


TATACTGTTCTCACCTTATAGAATTGTTGTGAAGATTAAATGAGACCTCCCTCAGCACAGTGTCTGCTCTAAGGCAGATGCCCACTG


GAGACATGGCTCCCTCCCCTGGACACATGACCATAGGCTGTCCACTCTTAATATGGGGCAAGAGCACAAAGGTAGTTTTGAAAGGCA


GCCTCAAATTTTAGGAGACTTTCAGGCTCCAATCCATGGACCAGAGAATTGGGTTTGTTTTGTGGTCTCTTGAGGAGGATGTGAAGT


GTGTTGATCTCCTTGGTAACTGCAGAGACTGCTCTCTCAAAGCCCTTTGGGTTAATTTCTGAGTTCGGCCAGGCCTCTGCTGGAGTA


AGTTTTCAAGGTGAACCCCAGCCTGGTAGACAGTGTGGTGAACACTGCACCTGCTGAGCTGACACCATCAGCCCATGAATCAGTACA


TCCCCTAGACCCAGATGTGGCGACATTTACTTGTAAGAGGCCTGGAGGGTAAATCCCCAAACTGGATCATAGCTGGAAGGATGAGAT


TTCCACTGGAAGAAACACATTTTCTTAGCAGATAGGACTTTCAGCATATTCATGTGAAGTACAGAAGCATTGAAAGCAAAAATGATT


ACCCCATACTTAATATCAGTCTGAGTTTTAAACCTAGGGCTAATATTGCAGTTCAACATTAGACATAATAATTTAAAGAATTCATTT


TGTCTGAGTTTTAAATCAACTGTAAAATGCAAAGGATGAGTGTCTCCAAGGGAAGCTGATTTATGTGCAATTGTTCAGAGATCATAA


GGATCTGCTGTTTGGAAGGAACATTAACAATTATGTGACATGAATCACCTCCACAACACCCTTGACAACATCCAGTGACAGTCAACT


CATTCATTCAGATAACATTTATTGAGCACATAGCATGGGCAGGGCTTGTGCTGAATTCTAGGGAAATGTGGATGAAGTGACCTAGTT


TCAGTCTTCATGGAGTTTATCCAGTTGTAGGAAGGGTGTGTGCATATACCTAAAATAATACACTGCAATAAATGCTACTTAGGGGTG


TATATATGTTTAATGGTTCCCACAGCAAAGTGCTCAGCATTTCTGTCTCTTTAGGTTGCCCTTCCTGTTGGAAAGACCTTCATTCCA


CCGAATTAGAATCATGTCCCACTAGTTTTCACTCATTGATTCTGGATCTACCCTGTTGGATCCCACAGAATAAGTCTTTCCACATGT


TAGCCCGGGAGGTATGTCAGGGTGAGGGCCTGGTTCCTTCTGAGTTTCCAGGCTAAACATCTGCTTCTCTCTAGGTGGTCCTCACAG


GATGTGGGCTGGAGCCCCTTGTCCATTTTGTTGGTGCTCATCTGGCCCCGCTCTGGTGTCTTTTCTGCACCATGGAGAGGAAGCTTT


AGGGGCTGTAGAGAGTGTGGCTGGATTGCGTCCTTTCTCCCCTCATCAATCTAGCTTGGGATCCACTGTAGATCACGGTGTCTGCAG


CTCACTGAGAGTCCCAAGTAGGTTGCAGACCCAACTGGTTACCCCATCCACCTCACCTATGGCTGATTTTCATAGGCAGTTGCAGGA


TTCCACAATGACACAGTGATATTTCAGCCCACCTGTCCACCTGCTGAGATCACTCCAGAGCCTCTATCTAGCATCTTCCCCATTCCG


CCCAGCTTGATTTCAGCTATACATTTTGATCAACCTCCTCCCTCTATTCCTTCTGCTAAGGCAGACTGTCCTTTTGCCCCACCATGC


CACCTGGGAAAATTCTGATTCAGTAGGTCCAGGATAGACACTGCGATGCTCTATTTTAACAGGCCTACTAGATTGTTGTGACTGCAG


TCAAGTTTAGTTATCATTGATAAAAGCCAGTGACATGCTGTTGAGCAGGCCAAGGACAGAGCCCAATGACATGTCACTAGAAATTTC


CTTTGGGGTTGACACTCATTCACTTATGTGTGCCCTTGGGTGTCATCAGTCAAGGAGTTTCTCATCCATCTACTTGTCATTACATCA


GACTATATTTCTGCATCTTGTCTTTGTAGATAGATGGTATCTTTCACTTTTTCACTGGTTAACTGGCCTAGGCACTTAACTGAACCT


AGCACTTTCTTATTGAACCCATGCTGGGTCCTGAAGCACATCATTTTCTCATCCAGGTACTTGGGAACCTTTATCAGCAAAGCAAGG


ACTAAGGCATAATACATCACTCCTCAATTCGAGAAACGTTTTCCTCACTTGGCTTCCAGGATATCACACTCTCCTGGTTTCCATACC


TCACAGGTGGTGCCTTCTCACATGTGTTTGCTAGTTCCACCTCATTTCCCTGACCTCTAAATTTTGGAGTGCCCAAGGCTCAGTCTG


AGCTTTGACTCGTCTTAAGAAATCTCATCTAGACTTGGGGCTTTACATGCCATCTGTCACTGATGACTTCCAAATGAATATTTTTGC


TTCCAACCTCATCTGAATTCTAGACTTGCATAGCCAGCATCCACACTGAAATGCCTGGTAGGCTTCTGAAACTTAACACATTCAAAA


CAACACAAGTGATTCTCATGCCCTCCCAACCTGCTCTTCCCAATTGCGGTAAAGAAACAACTCCACTCTTCTACTTGCTCATTCCTG


ACACTCTGCTTTCTTTTCTCCTCATACCATATTCAGCCCATCAGCAAATACTGTCAGCTCTACTTTGAAACTATATTGAAAATCCGA


TTTCTTCCACCACCTCCGCTGTTATACCCTGTTCTAAGTGGCCACCACATCTTGCCTGCATTTGTGCAGAAGCCTCCAATTATCTCC


CTGCCTCTGCTCTTGCACCCTGACCCTCACCCTAGGGCTGTCTCTGTGCAGCAGCTGGAGTGATCCTTTGGAAATGTAAGACAGATC


CTTTTACTTCTCTGCTTCTAGCCCTCCAGTGAGCTTATCTTCTCACTCAAAGCCATATATGGTGCCCATGGCCTGTGTGACATTTGC


TTTCATACTGTGTGCTTCCTCACTGTGTCCTATGGTCCTACTTATCAACTTGCTATTCCTCCCGCATCCCAAACATACCCCCACAAC


CCCAGGGCCTTTGCACTTGCCCCTGACTGGCATGCTCTTCCCCAGAAAACCACATGAGTGCTATCTTCTACTTCCTGGTTTCTTCTC


AAATGTCACCTTTGACCTAGCCCTTTCTTCCCCTTCCTTGTGTTTTTCCTTCTCATGCGACTCATCACTTAGACGCTAACAAGTTTA


TTGCCTGGACTTTTTATTTATTACCACACTCTAGTACCTAGAATGTTAGATGGCACATAGCAAGTATTCAAGAGGTATTGCTTATGA


AAGAATGAATGAGCAAATGAGCAATGACAGCATTCTTTAAAACACTGGCTATGTCATGGAGTTATAGAAGTCAGTACTTGCCTCACA


TCTCCAGTAAGCATACTATATTAGCGATTCTTACAGAATAAAAGGAGGTAAATACGTGTGGTTTCTGAAGTCTGATTTGAGAATAAT


ACGGGGTTAGAAACAAAATATATATATTGTCTATATCAGAAAAGAAGAAAATTACTTCTCTCGTAAAAGTGGAAATCTATATATGAT


TATCTCATTTCATGGAAAAATTAGGGATGCCATTCCTTTTCCGTTTTGCTCAACTCTTATGCTTATTACTTAGTTCTTAAGTGGGAG


CAAGAGGGAGAGTGATCACTCACAATTAGAAATAAAGGTATTGGGGCGAGGGAGGACTCAGCTTTTCAGAGGAGGGAAAATGCCTTT


CCCTGGTCCTTAGTGTGAATTGAATGTTCCCATTCTGCCCCTGCCTCCCTAATACAGCACCTAGCCCACTAAGCAGAGTGGATACCT


ACTCCTGGCTTGTCTGGCCTGGAAACTCCTTGAGGACAGGAGCCTGTCTTTGCCCTTTATTCTCAGTTCCTACCACAATGCCTCCTA


CACAATGGATGCCCAGAAGCTGTTTGTGACTAAGCCAATGAGAACATGCAAAAAGAGCTTTACACGTTGTAAAATGCTACACAGGAA


AAAAATACCACTTTTTATAAAGGAGTTGCATTTGCACTTCCCTGACTTCTGGATCCCCTCAAGTTAACTTTAAGAGAATGACATTCT


ATTTCATAGGTGGGGAAACCAAGGCACAGAGATGTCAAACTGGAAGTCTGGCCCTCTCCCTCCCAGTCCTCTGGCCAGTCCCCTGTC


ATCCTCCATTGCACTCACTACGCTGGGTTCTCTAGGGGTGATTGGAAGGAAAGAACTGGTGCCCAGTGCTGATCCCAGTAGGGAGAA


GGGGGAATTAGAGGAGCTCTACCCCCCATATTGCTTTTCTCCTTGGCTTTGCTGTAGATGATGTTTCTTTTTCCTGGAGGGTTTTTC


CCAGCCCACTGTCTGTGATTTTAGGTCTCAATGCAGAACACTCCAGTTCTTCCTGTCACAATTATACAGGAGACTCACCTTGGAAAA


CCTTTCCCTATTTGCCGAGGAAGGAAAATTCAGTGAGATTCATTGATTCAGGAATGTCATAGCAGTACAGGCCAGTTTCTGTTGCCT


GAGGGAGGCAATAGAGGAAAATGGTTACTCAGATGACTTGAGCAGAAAAAAATAGATTTCTTAACATTGAAACTTCTTTAAGGAGAC


ATTACTGAGATGCTGAAAATACTTCTATGAAGACTTGGTTTTATTGACTGAAAGTAGATTGTGATTCTTTTCCTCAATTATCCCAAT


GATTCCCTCAAGTTCTCTGTTGTATCTAAAGAGCTGGAAACCGGCCGGGCGCGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAG


GCCGAGGCGAGCAGATCACGAGGTCAGGAGATCGAAACCATGCTGGCTAACACGGTGAAACCCCATCTCTACTAAAAATACAAAAAA


TCAGCCAGGCATGGTGGCAGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGTATGAACCCAGGAGGCGGAGCT


TGCAGTGAGCCCAGATCACGCCACTGCACTCCAGCCTGGGCAGCAGAGTGAGACTCCATCTLAAAAAAAAAAAAAAAAAAAAAGAGC


TGGAAACCAAACAGCTCATGGTCAGTACCTGGAAGCTATGTGATCTGATGTGCTCTAATCAGTAATGTTTCACACACACATGAAGTA


TATGGGAAGAAAATTTAATGTTTCTCTATGTATTCCCCTTTAAACTGTATTCAGTGGGGTTTCTTAGGGATGAAAATTTAGTTGGGT


CAAAAATTCAATGACTTTGTTGTTCACTCTCAGATATCACAGTCCTTCTCTCACTTTGAGGCACAGATCCAGGCCCAGTGATTAGAC


AGGGCTGGATAATAAAACTGCAAACCTAACTTTGCATTAAAATGTTCTCCCTGCCGAGCCCATCAGCCTTGGCCCCTGAGGAGGGAA


GGGAACATGGGCCCTTGCCCTCTGCATCCTCCTTCTGGCCCCTGGCCCTGCCCAGATGCCTCTGCCCACCGCCTGCCCGGGCAGAAG


CTGGGGTGGGCTGTGCTCTCTGGGCCTGGTGGAAGTTAAAGAGGAGAATATCCTGGTCTTTGTGAAGCTCCCCTGCTGAGTCCCTGT


GCCTAGTGATTTCCTTGAGCTTGGTAGCCATCTCAATTCCAGGTGACCACCTGGCAGCCCTGCTCATCCCTGGCCACCTTCCTCAGC


CAGTGCACCTCTGAGCTCTGCCCTCTGAGGTCACTTCTTCACACGCCTGCAGGCAGCCCTATCTGACAGCGTCCAGGATGACCTCAG


GCCACCTCTTCCGTGCTGTCCCCGTGTTTTCTCCAGGACATACTCATCTGGGAGCGAGGTCAGTGCCCCCAGAACAGCCCATTGCCT


GTCCTCACCTACTTCTGATACCAGAGCAGCCAGCCGGCCCTTCTCTCTCTAGGTTGCAAGGGCAGGAGGCAGCCCACAGCCCCTTCC


TAGGCAGAGTCGGGCCCTAATGGCTGTGCGGGTCAAGTGCAGAGAACCACTTCAGAGCTCCCGGGAGGTGCCCTTGGAACTCCTCCT


AAGGTTTAGGGTGAGAAAGAGGCTATCCACACTCCACCCCCAGGCCCTGGGCAGTGGTGTCACAGCACAGCAACTGCTTTCTCCAGA


GAAACCTTGCCTCTCAGTCCTCCTCTGACCCCTTTTGTCCCTGCCAGATTTCACCGAGGCGCACAAAAGAAAGATGTCCTTTGTCGG


CGGTGGTGGAGGTGGGGTGTGGTTGGGAGGTCTTGTCTCCTACTCACTTTGGTTTTCAGATAGTGATCAGTGAAATCAGAGGCAAGA


ATGTTATAACATATTGTGTATATTTTTCTTAAAATTTTAGAAACATATGTATGATGTTACGTTGGAAATAAGAATCCTCCTGCCAGC


TGCTACCCCAACTTCCAGCAATAGATCACAGGGAGTGGTGTGAACCCTGCTCTTGGGTCAGGCGGCCCAGGCTCAGAACCCTGCTCT


GTCACTTCCTGACCTGGGCTACCTGGGCATGTTAGTTCCTCTCTGTGTCTGTCTCCTCACATGGGTAAGAGTGCCTGCCTGGCTGGT


TTCTGGTGAGGGTGAAGTAGTCCAGGTAGCCCAGTGCCTGGCTGGAGTCACTGCTGAGAAGTGTAGTTCTTTTGGTGCTGCTTTTAT


TCAGGCCTTCAGCAGATCTCACCTGGATCACCCCAGAGCCTGCTAGCTGCTTCCACAGCACGTGACTGCCACCTGAGCGGGCTTCTA


AATTCAGAAATGGCCTGGAGCTTCCTCTGCTCCAAATGCCCTCAGATACAAACCCAGCCTCGCCCAACCAGCCTCTTCATCTCTTCT


CACCGCTTGTCACATAGAGGCCCCACTGGGCCAGATCCTGTCGCTTTGTCTGCACTCTTACTGATAGGACCTTCTGCCCCTCCCCAT


GCACCCCCATAACACCCACTGCTTGTGCCTCTGCTCCATGCACTCTGTTCTTAACCGTCTCCCCTCTAGACTCAGCTCCTGAGGGTG


TCACTGGATGTTTTGCTAGAAATACCCTTGACTGACATAATACCTGGCAACTCACAGGTGATCCTCATGAAAGTATTTGCTCAATAA


ATGAACGAGTCTCATATTTTTGAGGTCCCAGAATAGAGGGTCACCTGCCGCTAGTCCAGACTTCACCTTTTTTCACTTGAGTTTAGG


GGCACCATGATCAGAGCCTGTTTTAGCTCAGGCTGCTGTAACAAAATACTATAGACTGGGTGGCTTAAATAACAAACATTTCTCTCT


CACAGTTCGCCAGGCTGGGAAGTCCAAGATCAAGGTGGTGACAGATTCAGTTCCTGGCGAGGGCCCTCGGTTTGCAGCCGCCTTTTT


GCTGTGTGCTGGCATGGCAGAGTGAGAGAGGGAGGGCCCTGGTCTCTTCCTTTTCTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTC


TCTGTGTCACCCAAGCTGGAGTGCAGTGGCACGATCTCGGCTCACTGCAACCTCCGCCTCCTGGATTCAAGCAGTTCTCCTGCTCAG


CCTTCCGAGTAGCTGGGACTACAAGGCGCACGCCTGGCTGATTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTGGCCAGGC


TGGTCTCAAACTCCTGACCTCATGATCTGCCCGCCTCAGTCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGTGCCCAGCCTC


TTCCTTTTCTTATAAAGACACTAATCCCATCATGGGGGTCCCACCCTCATGACATCTTCCAAACCTAATTACCTCCCAAAGGCCCCA


CCTCAAAATACTACCACACGGGGGCTTAGGGTATCAGAATGTGAATTTGGGGGAGTCACGAACATTTAGTCCATACCAGAACCTCTA


TTAAATCTTTCAGCTTAAACTTTACACCTAGGCTGGAATGTTTCTAGGTATGTCTCCCGTCTTCTGAATCTAAATGAAAATATCTGG


GAATGGCTGAGAACATGGGTGATTTCTGAAAGGCTGCGCTTTTGCATGTGGCTGTTTCCACGCTGATGGGGCAGTGGCTCTCACCAG


AGTGTGTAGAGATGGTAGTTTCCCTGCCTGTGAGCAGTGCCACCTGATGGAACTTGGTACCGCTGGCCTCCCCAGCAGCTACTTGAT


TGCAGGATTGTATGGAGACCTAAAAGATGACTACCCCTCCTTCTCCTCTTCTCCTCAAAGGCAGGTCATGGCCACTTTTTAATCTGC


AAAAAAAGGATTACTTGAGTTTCACTAATGACCTTTTTTGACAAGAAAAAATGGGAAGGAGCCATGCACCTTTGAAGCAGCTAGTCG


TCTTTTATCCTTGTATCTCTTTGCCAGGCATGAACTAAGCTGCTCTTGCTCCCTTACATCTCCCTGGACTGTTCAGGGCCTGACAGG


CTTTCTTCTCATTCCTAGTCGTCACTCTGGCCTCTGCAGCAGTTCCTTAGATAGATGGATGTTTGGAGTTTTACAGAGTGGCGGAGC


ATCTTTGACAAGTTTTTATAGGGGCAGGTTCCTCTGTGGCCCTGTGGTCTCTATTTGTTCTTACTGTGCATACTGTTTAGAACCACA


TTTCTAACTCTCCAGGATCACCCCTCGCTGAGTAGCTGTATTTTCTTTGAAATGTCATTCCTCGTTACCCTTTCTCACTAGGGAAAT


CCTTCTCTATCTCTTACTCTAGGAAAACTGTTGTCAGTAGGATCTGGTTTATGGAGGGGTTGGTGAATCAAGAGCTAGTCTCATAAA


TCTCAAAGGGGTCCATCTGGCCCAGCTTTGGGTACACATTTCATAGGCCTGTCTCTCTCTCTTTCTTATCCAGCAGTTGGAAGGAAT


GTGCTTGTATATGCAAAAGCAGAAGAGTCCCAGACCTTGGGGTTTATTAATGCTATTTTTGTATTTCTTTTCTGTGTGGGTTGCGAG


AAGAAGCTTGCCAGGTGGCACACAGAGGCTCCTCTGTGCTGGTGATGAAAAAAAAAAACACAGACACTCCTGAAGTTTATTGGTGTG


GAACCCTTCTGGAGTTTTGTTTGCCTTTTCGTTTCTGCATGTGCATAGAAACCTCTTTCAAGAAGAAATAGTTACTCAGAACATATT


CCTTTATTGCAGAAGCATGGGGAAGAAGCTGCTTAAATTCCAGAGACAGCTGAATGAATAAGGCACTAATGAGGAGAGGGAAGGTTA


GCTGGTTTGTCCTTTTTTTTTTTTTTTTTGAGATGGAGGCTCTCTCTGTCTCCCAGGCTGTAGTGCAGTTTCGCAGTCTCAGCTCAC


TGGCGTGGGCAAGGTCCGCCTCCCGGGTTCATGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACTCCCACCACCACACC


TGGCTAATTTTTTGTATTTTTAGTAGAGACAGGATTTCACCACGTTAGCCAGGATGGTCTCGATCTCCTGACCTCTTGATCCACCCG


CCTCGGCCTCCCAGAGTGCTGGGATTACAGGCATGAGCCACTGCGCCTGGCCGGTTGGCTGGTTTTTCACATTCTTACTGAGACATA


CTGTGTTCATCAAACCACTGAACAGCCAGATCTAACGGGGATAGAACATAGTTCAGCCACTGGAAGGTCACTCCAGAGTGGTGACTG


ACAACCAGTGTGCCAGTCAGCACCCCAGCAACAGAGGTATCCTTGCTCCTGGTTCCATGTGCCACCATCGTGGCAGCACCACTGCTG


TCTTACCGCAGTCACTGACTCCTCCCTGCTTTCTTCTCTGCTGCACCACTTCTCAGTACCCTAAGCTTCCACCACTCATGGCTTCTG


CCTACTCCTGGCTTCAGCTTCCTCATGGCCTCCCTCTTCTGCCTTTTCTCTCCATGTCTTAGATTATTTCCAATTCCCCCCAAAAGA


AGATCTTATTAACAAGTTAGTGACTGTCACCTCTGTTAGGCATGATCATCAACTGTGGCCATGGCTTTCCTTAGAGGGGGTCAGCCA


GGGCAAGTACCCAGAGCAAAACAGTTTCTTCTCCAGTGCAGTTGGGTTAGACACTCCTCCTGGGTGCCTCTACAGTGTCTGGTGTCT


TCTTCTTGTTCTAATAATTATATTATTAATATAATAGTGATAACAGTGATTATGGCAATATACTTTTATTTAATTCTTATTATATTC


GAAGCACTTCACATCGTGTTTGGATTTACTTGGATTGTTTCCATCATCCTCATAATAACCTTAGGACATAGAGTACCATTTTCACAG


ATACAGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTAGCATTGGGATTCAAGACAAGCTAGTCTGTATTAGTGTCTGTC


TGTTTGTCTGTCTCCCCCATTGTCCAGGCTACCCCACTTTCTGAGTTTTGGATTTACTTGGATCCCAGGCGATATTGGAGGTGAGCC


TCATTGGCTTAAGTACAGTTCAGGATGGTTTGTTCAGGAGGAGGTTGATTCTGGAATGCTCTCTCTGCCCCACTCTAGAGCAGGCTA


GTCTAAGTGGCTGGAATATCAGAGTCTCCCTTGTACCAAGATGGGTGCAAATGGATACATTGTTGCTTGTTGGCTCTCTAAACTTCT


GTTACAATCCTATTGCCTCAGACATGGACCACTAATGTGTCTTATTTCTTCTTAGACATATACTGGTCTCTTTGCTAAGTTATGAGA


GATGCTGTCTGGTACCTAGTGGATAATGGAAATCTCCTATTGCAGAATCATCTCTTAAAGGCTTCAAGTGGATATGCCAGAGTTAGT


TGTCCAAAAGCTAATTTGCAGAATGGCCAATTTGTTGAATATATTTTTTTCTTTCAACTTTTTAAATTGACTGCTATTCATTTTGTC


TTTATAGCAGCACTTTATGTTATGGTCAATTTGTTTTTTGCCTCTGCTGCCTGCTGCAACAACAGCTGTAGACCTCAGAGGCAGGAG


AGAGAAGATTAAGGATCCTAAGAAGAATATTGACATAGCATATAAGTCTGCATACGAAGAATTCTTACGAATATATTCATTTATATC


AGTTCTTACTAATAAAATTTTAATGTATTAATAAGATATATGTAGAGGAATTCTTCCCACATAGCATTCTGAATCGATCATCTTGAA


TATATTTTTCTCATCACCTGCAGTCTTGGTCTCTGGCTCTCTCTCATTCTGAATCTTTCTGTTTCTGCTACTACTGTTCAGAATCTC


ACTTTCATATGTCAACTAAAACGGATGGAAATAACtGTGTGTGGCCCGTTACTCTGCTTCTCACTCATTTATCCTTGTTCCAGTTAG


GTTCAGCTTCATGGGATATTTTCTGATGTTATCTGCGAAGTCTAGTACCCTTGACATCTTTAGCCCCCAGGGCTTGCTATGCTTGTA


GGATTCAGGTAGGAGAAGGATGAGAACTTCCTATGGAATATAGATGCCAAGCTCTGTGTGTGCACTTCTGGCATAAACAGGTACAGA


AGAGAGTAGTCAAATAACATTTTGTATTTATTTACTTATTTATGTTTTATTACTTTTTGAGATGTGATTTCACTCTGTTGCCCAGGC


TGGAGTGCAGTGATGTGATCATGGCTCACTGCAGCCTCCAACTCGTGGGCTCAAGTGATCTTTCTGCCTCAGCCTCCCAAGTAGCTA


GGACTACAGGCACACACCAGTGTACCTGACTTATGTTTAAATTTTTTCTAGAGATGGGGTCTTGTTTTATTGCCCAGGCTGGTCTCA


ACTTCTGGCTTCAGGCAATCCCCCTACCTCGGCCTCCCAATGTATTGATTTTTTTCCGTGTTTGAGGTTTTAAAAGTTGGTATTTAA


ACTCAAGGGCTGAACATTCAAGTTTACATGCAGAATTGGAGGTTAAACCATGTTATGCATTATTTGTCAGTAACATAGACAAATCAC


CTAAAAGTTCCATAAGAGTTCCACAGAACTGCTCATTTCATTGATGATGCTGAATTCATAGTGAGTTAACATGAATGAGACTGTTTA


CACCGGCTTAATTACTACGTTGACTTGAAATATCAGCCAGCTGGGGAAAATGACCATTTAAAACCTGGCACATCCCTTTGCTCCCTA


TACCCACATTTTTTCCCAGCTTCGACCACGTGCGTGTGTCTGTGTGTCTATGTGCATGTCTGTGTGTGCGTTTACGTGCATGGAGGA


CTGAAGCATAGTGTATTCAAAGCTTTTGTGTTGTGCAGGACTTCGCAGATGCAAATGAAGACCCAAAGAGAACCAGCATAAGCAATC


AAGGGAGTGTATCTAAGGCTCCTGGAGTGACACATAGAGCTCTAGGGCAGGCCTCAGGAACCACTGGACTGGGGATTTATAATGCTG


TCTGGATTTTCCCTCCCTACTCTTGTTCTTTGTTTCTTCTTGAGCGCGGTTTTCTGCTTCTCACTGCTGTCTGACTTTCTCCACTTG


GTAGGAAATATGACATGCTTCACAAGGCTCTGGAGTTTGGCATTTTAGAGTCTCAGCCACTAGAGAAAGGTGCCTGTTCTAAATCCT


GGCACTTTAGGAAGGGAATCCAGGCTTCTCAGCCCTCACCAGGCCAGCAGGATTGTATGAGATCTTGGCAGCTCTGAGGGGTCATGG


AGTGAAAGGAGGGGCGAAGGCATCCTTACAAGGAGGAGGTGGTGCTGTTCCCAGAAGAGGCGGGGGCCTCAGGTTCCCAGAAGACTA


GGTGTCTGCTGGTGGTGTTCTTGCACATTCCTAAGGATTTACTGTGAATCTGGTGCCTGTTTTAAATTGCTTGGCAGACTTAACTGT


AATCTTAGATTTTTTTTCTTACAGCTTCTTGTCAACTACAAGGTTTAATTATAATTACTCTTCAGCAGGCATATACTAGCACTTCTT


ACTCATCTGTCAAATTGAGCTGAATGAAATTAAAAAGTCCAGAAAGAGACCCCATCTTTAGGACAACAGAAGACTGAACAGTCAACT


CCCTATCATTTTTGTAATCCAAATCACTGTTGTCAGGATTATGTTCCCCCCCACCTTTTTTTTTTTTTTAGACAGAGTCTTGCTCTG


TCACCAGGCTGGAGTGCAGTGGCTCAATCTCAGCTCACTGCAACCTCTGCCTCCTGAGTTCAAGCGATTCTCCTGCCTCAGCCTCTC


GAGTAGCTGGGATTACAGGCAGGTACCACCACGTGCAGCTCATTTGTGTATTTTTAGTTGAGACTGGGTTTCACTGTGTTGGCCAGG


ATGGTCTCGATTTCTTGACCTCATGATCTGTCCGCCTTGGCCTCCCAATCCCTCTGTGTAGTCAAAAGCAATAAAACTGCTGCTCTT


CAGTGAATGTTGGGAAATTGTGCACAGATGAAAGAATAAGTCTGTTTTTTTTCTCCTGCTAGGTAAGTAATCCCTAATTTTCCCTAA


TCCCAAGGGGAAAAATACTGGCCATTGGGCATTGACTTCCACATTCACTTCTTGTGTTTCAAGATTTGAGGTAGTGATGATGGCTAA


TAATATATTCTTGAAAAATGCCGAGTGGATGTAAAGTGTTCTCACCACAAAAATGATAACTATGTGAGGTAATGCACATGCTAACTA


GCCAGATTTAGTCATTCCACTATTTATATATACACGCACCTCAAAACATGGACATGTACAATACATACAATTTTTTTTTTTTCTGAG


GCAGAGTCTCGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCCAGGCTGGAGTGCAGTGGTGCGATATCGGCTCACTGCAAGCT


CCGCCTCCCGGGTTCACGCCATTCTTCTGCCTCAGCCTCCCGAGTTGCTGGAACTACAGGCGCGTGCTCCCACGCCCGGCTAATTTT


TTCCATTTTTAGTAGAGACGGGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATTTCCTCACCTCGTGATCTGCCCGCCTCGGCCT


CCCAAAGTGCTGGGATTACAGGCGTGAGCCATCAAGCCGGGCCAATACATACAATTTTATGTCCATTTCAGTTTTTTAAAATTTTAA


AATAATTTTAAATAAGTAGATAAAGGATATATTCTTTTCACCCAGGAAAAAAAAGATTTGAGTTAGTTTTCAACTGATAACTACGTG


GGTATATTCTGAATCCATTAAAAATAAAGTTCTTGGTAGTCTTTCCTATGCTTTGTGGGAGATTAGTTCCCCCCAGCACGCTGTAGT


ATCTGTTTGCAGCTCTATCTTTGCCAGAATTTAGGATTAAATAAGTAGAATCTGCAGTCCAGCTCAGCCCCCCAATGATTGTTGTTT


CCGTGGAAACAGTTGAAGGCTCTCAATTAAAACTGCCTCTGAAGGCTGGAGAGAGTAAGTATTAAAATGAGTTTGTCTGAGAAGCCA


ATTTTTATCCTCCAAATTAAACCCAGAGAGTGCAGATGATCTAGGAATCTCCTGACAGTTGGGATCATACTTCTTTGTCTTTGGGGG


AGGGATTATTTTGCTATTTCGGGCATAGGTATGTTTGCTAGCTTGTTGCTTGCTTTGCTGAGTTGCTCAGATCATCGTCTTTGTTAC


CCACTGAGCTCTTTATGTACAACCATGGATCATGGGCAAGGGTTTGGGAGCAATCTGATCTTTGTTCAGACTTGTGAGCCGCAACTA


AAAAGCCCATTAAAAATGGATGAAATCATAGAACGGTCTCAAAGTTGAAAGGAATCCTAAAGGTCATTAAGGCCTAATTTCCCATCC


ACTTTGGGAATCTTTCCTAGAATGCTGTTGACAAAGGTTCACAGCATCAGCAACCCTGTTGGGGAATCCCGTATTTCTCAGGGCAGC


CTTCTTTGGTTCATTGAACAGACTTGGTGGTATTGTTACCGGGGGTCCTTGTTCTTAGAGCTCCCAAGATGGTGGCGGGCCGCTTCC


AAGGTGGCGGCAAGCCTCTTGTTCTCTGACCTGGGGTTCTTGGCCTCACGGATTCCAAGGAATGGAATCTTGGGCCATGCATGCGGT


GAGTGTTATAGCTCTATCCAGCTCGATTAGGATGAACCCTGGGCACTTAGACCGTGCAGGAACAATGGCGAGCCTCTAGCCCGATTA


GGAGTGGCAGTGGGCACCTCGCTGGATCAGGAGCACAGCGGATACCCTGCCGGATCCGGAGGGGTGGAAGTCAGTGGTGGCTTCTAC


AACGACGGCAATCAGCAGTGGTGGACGGCGAGTGAAAGCTCAGTTCGAACCAGAACAAACACAGACCAGAGAGTGTGCAGTTTGCAA


GATTTAATAGAGTGAAAACAGAGCTCCCATACAACGGGAGGGGACCCAAAGGGGTTGCCCACTCCCTGCTTGAATGCCTGAGTTTAT


ATCTCGATCATTGTCCCTCCCCCTGTGCTCTCAGGCGATATATGATTTGACAATTTCTTTACCTCCTGCTTTAGCCTAATTTGTATT


TTAGTGAGCCTATTTACTACCTGATTGGTTGGGTGTGAGCTGAGTAGTTACAAGCCCCATGTTTAAAAGTGGGTGCGGTCACCTTTC


CCAGCTAGGCTTAGGAATTCTTATTCGGCCTGGGAAATCCAGCTAGTCCTGTCTCTCAGTATTAGAAATGCCTCTTTATGATGGAAC


TGACATTTCTCTCTGTCAATTCTGCTACTGCTACCTCTTCTTTCTGGTGCCAAGTTAGCTGTGTCTTCTTCTCCCATAATTAAGCTT


AAAGTCTTTTAAGAATGTCTTCATGTATCCCCAAAGTCTTCTCTCTCTTCCGGTGGCTGAGAAGGTCCATAACCTGAAAGCTTCAGG


TACTAACATCTGTGGTTAAAGGCATTGTCAGAGGAGAGGCTGGTTTCCTAACAACCCTGGGCCTTTAGCACTGTTGCTTGGATTTTT


TATTTTAAGTTTATTTTTGTAGAGAAAGGGTCTCGCTATACTGCCCAGGCTGGTCTCAAACTCCTGGCCTCAAGCGATCCTCCCACT


TCAGCCTCCCAAAGTGTTGGGATTACAGGTGTGAGCCACTCCACCCAGCCTGTTGCTTGGATTTTGTCCGACTTCTCTGGCAAGTTT


TTTCTCAGCATCATTTGTATAGGTGGAGAATTTGGTTTGAGTATTTCTGTTTTCCTTCAACCTTTTCCCCCGGAGTAAATATTCATA


GTTCACTGCTTGGAAACCCAAGAAACAAAATTGGATCAAACCTTTGGTCTATGCAGACTTGTGAAGGGTGTGGTTGCCTTCTTTGAT


GTCACCTCAGAAGTTAATGAATACAACCTCAATCCTAACTGCTTTAATAGCCTTTCAACCATTTGTCTGTGACATTAAACCTTAGAC


TTTTTAAAATTAGGTTTAAGTTTTACATTATAAGAGTTCTTTATTTCCCCATATACATTCTGTTCTTAATATCCTATTATTGTTCGT


AAGTTGACACCCCCCTAAAGGAAGAAACAGACAGAAAAATAGAACAAACGAAATACGCTTCTCCAAATGTTCCTACCTACAACCTTT


AAATGGATTAAAACTTAAAACTCCTAAGTTCAGATGTTGGTTAGTGCTGACTGGGAAGTACTGGGAAGCAAGTGTGTGGCCCCTGCT


TGGTACTGAAATAGACATTGTGTACTGGTTTCAAAGAAGCGATGGCGTCTGTCACCTTCAGCCCATCACCAAACTGCTCTGAGTTCC


ATTTTCCTCAAGTATAAAATCAGATGATTGCTTCCTGTTCTTACAGGTTATTGGGAGTGCTTTGAAAACAATTTTTTTTTATTATTA


AGGCTTTACAGCAAACTATACTGTGATTCTCTGGAGGTATTTTGATTTGAGAGTACCAAACAACTTCAATAAAATTAAAATATTGGT


GATATTGGCTGTTTAAGGCCCATGCACATCCACAGTTTCAAAATAATCTTGTAACATAGGTTCTGGGTGGTATTTAATATGGTATCA


CACATAAGGGAAGAGGGGATTTCAGTAAAGAAATGTCATTTTTTGTGGAAAAGTGAAATTACTCGAGGTCCGTTTGGTGTTCTTGTG


GAAGAAGAATAAGAGTTGAAAGTGAGGAAGTAACCTTTGATTTGTAAATCATTTAAATTTCAACTCGAAGGGGGTAAGAAATACCCC


AACAGCAAGCCACAGAACAGCCACCAGAGCAAACCACACAAGGCTTTTGGGATCTCAGCCTAATAAAGGTCTCCCATGGAGCTCAAG


AGTAGATCCTGAGGTACGATATTTTCTTGGAAAAAAAAAACTTGTAGGTGTTTGTAGCCGGACCGGGTGCTGTGTTAGTTTTCAGCT


TCTAGCTCGATCCTATTTCCTGAGAAATGCCAAGGGCTTTGCAATAGGCATTTGTCTAACTTCTGCGTGAATTGGGTCTTACAGAAG


ATGACCTCCCCCCTCTCTGGGGGTCAGGGGGTGTGTGTGTTTTTTATACATCTGTCTTTTTTTGTTTGTTTGTTTTTACTGAAGACC


TCTTATATTTGCAGACACTGAAACCAAAGGTAACACCACGTCTTCTCCTTACAGGGTCTAATGACAGTTTCTTGGGCTCTTCTTTTC


TTTTTTTTTTTTTTTTCTCTACATATAGTTTTCCCAAAAATATGAACACGTTTAGATGTTGGAAAGAAAGCAGTTTCCCTCCCTCCT


TCCCTCCATCCCCCCCTCCCTCCCTTCCTCGCTTCCTCCCTTCCTCCCTTTTGTTTCTCTCTTTTCTCTTTCTCTCTCTTTCTCTTT


CTTTCTCACTCTTTCTTTCTCTTTCTCTTTCTCTCTCTCTTTCTTTCCTCTCTTAAGTATTAATCACATACCTGATAATCAGATGCC


CTCTGAAGGTTTTCTTTGGGAGGGGAAAGGACAAATGCAATAATCTTTACATGTTGGAAAACTGACCCCACATCCCCGTGCCTTGTT


GTGTGTTCTTTTCTGCTCCCAGGGAGTTCTGTCCAACATCTCTTCCATCACCGATCTCGGCGGCTTTGACCCAGTTTGGCTCTTCCT


TGTGGTGGGAGGAGTGATGTTCATTTTGGGATTTGCAGGGTGCATTGGAGCGCTACGGGAAAACACTTTCCTTCTCAAGTTTGTAAG


TATTCCACTCTCTACTCTCAGATTGAGAGCCAAAACTTTACCTTCCATCAGGAGGTCACCCTATCTACAGGCAAGACAGTGAGCTGT


ACCAAAGGCACTGGCCAAAGTAGGGCCCAGGTCATTATTTTCTTTTGAGAGAGCTCTCTAGCCCTGATTCCCAGTTGTGCCTCCTTA


ATAAGTACAACACCACCCCCACCACCCCACCATGCCATCCATGGAGGTTTTGTGCATATATATCACAGACTTGGATTCCATTCCCTA


AGATATCTTTAGGACTAAGGTAGGTATATATATATATTTTCTTCTAAGTGATTCCTTCCCACCGTTTTAATGCACATAGTAAGTGGG


GAGCTGTGCAGGCTGTTGGTTTGGAGAAACCAGGCAAAAGCACAGTGACTGTGGCCTGTCCAGATTAAATCTGTTAAGCAGTAGGTT


TTGCTAAATATGGAGAAACAGTAAAAGGTAAAGCTTCTTTGTCCTTAGCTGGTACAAAGTTCTCCTTTGTAATTTTTAGATGTGGTG


CGGTTGGCGTGATCACTGTCTGAGTGAATGTTTGTAGACGAGAGGTTTCACCAGGGGGTTCACTGGTATTTAAAGTTAAAATAGAGA


ATGAAAAGTGAAAGCCTTTGCGTTGGAGACTCGTTTCAAACGAGAAGAAAATGGCATGTGCCGTTTATGTATCTTATATAGGGTTGT


TGAATGTAGCCAAATGTGCCTGTCAGCATGGAGCTTGGCACTCTGATGGGCGTCTGAATCATAGCTCTCTATACGAAGCATCCATTC


CCCTTTCTAAGAACAGAGAAAGGATCCAAAGCACCCACCTTCATTTGCTGAGGAAGGATGGGGATGGTGGAGATTTCTAGAGAACAG


TTGTAGTGTAATATTTCCTGTTACCACAGTTATTCCCAACTTTTGTTGACACATCATCATCCAGGGACATTCTCATTAAAAAAAAAA


AAAAAAAAAAAAAGCATATCCAAGAAGTAGCCCAATAGTCATGTAATGTGTGATTCTCTTCCCCAGCATTTCTGCCACATCATCCTC


CAGCGTCTTTTCTTAAACATCCCTGAGAAGAGGGTACACGGTGTGCCCCACCCAGGGCAGCCCATTTCTGAGCAGCTCTGTCTCGGA


GAAGTTTTTGGAGGCTATTTAACCTGAAAATTAGCATGACTTATTCTAACAAAGAGAACCGAGGGGTACCTGGTCTTACAGATAAGT


TCACAAGCAGCTGGTTCTCTCTTGTGGATACATGGGACCACAGTGGCTGTAGCTAGTTTCCTAAGACTCCATCTGCCTTATCTGCCA


GATCCTTCCTTTGCCACACACACACACACAGTCTCTCTCTCTCTCTCCCTCCCTCTCTCATACACACACAACCAAATGCTTCATTCT


TCACCTAGTCAGAAACCTGGGGAGCCCCCAGGAGAGCTCTGTCCCTGATTGCCACCTGCCAACCTGCCAGTCTTCTTGGCTTGAGGC


ATCTCAGTGCTCCAGTGCTCAGCTCACCTTGCCAGCTTTCCTGTAGCCTGATTGGGTCCTGGTCATACTCATCTGTTGCCACTATTT


CATCAGTTTCGGCCTCCATGCCCCAAAATGTGGGATCCTTTTTTTTTTTTTAGATGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTG


CAATGGTGTGATCTCGGCTCACTGCAACCTCTGCCTCCTGGATTCAAGCGATTCTCCTGCCTCAGCCTCCCGGGTAGCTGGGATTAC


AGGGGCCTACCACCGTGCCTGGCTAATTTTTTCATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCC


GACCTCAGGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATACCTGGCTGGGATCCTCTGAATT


GTATTTTTTTTTTTTAAGTAAAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCCGACCTCAAGTGATCCACCTTGCT


CAGCCTCCCAGAATGCTGGGATTACAGGCATGAGCCACTGCACCTGCTCAGTCCCCTTAATTGTGATTTACTTTAATATAGTTTCAT


TTATAGTGGTGGCCCCTTTAATATAGTTTATCATTTCTTACAGTTGAAGAGTCCAGTGTTAACTGAACAGGCAGAAAACTACACATT


TCTCTAAATCAGCACCTTAATTTATAAAGTCTCATGTTGGAAATGAAGAGAATTGTGTTGTTTCTTGGCTTTTAAGACTTGGAAAAT


ATCTTAAATGGCCTCTCTCCATTTAGGACAAACAATAAAAACTTGCCTGGAATAATCTTCGAACAGAAGGTATGAGATAAGTACTAA


GTAAACGTCCACAGGACTCCAAATAGCTCTAAAGATCTGATTCCCCTAGGAGACTTGCTGAGGGAAAATCTAGGAACTAAGATACTG


CAAAATGGAAATAGACCTTCTTGGTTGACCGAGGCTCTAGGGTGAAGCCTGTGAGTCAGTGTCTGCACCTTTGGAAATAGAGGAAAT


TAGCTCAACAGGGCTTGGGGCATGTAGGTATCTGCCAAATATTTTATATGAATTGAATTTGGACTCAATTTTTGGTATGTATAATAT


GTAACATGAAGAGAAAATTTACCAGGGGAACTGGAAAATGCACTTAACTTTTATGGAGGTGAGAACAAAAACTGAATTAAAATCTTT


CCCTGACTTGGTGTTTCCTGTGTATGCTCATGCATGCTAGCTATAATTTTGTCATTTCTGTACTGTGATAATTCATAATTCATATTT


ACATGCTTAAGGTGGGGCCTAATACAGGGCAGGGCGTTATTTACACTGTAGGGTAGGCATTGAGCAGAAGTGGTGTGATATTTTTTC


TGTTCATTTTTCTAGATTGGCGAAAGTTTAAATTGAAATTATTGGCATCACTGATGATAATTAAGAACTGTTTAAATTCCATTTCTG


GCGAATTCCTGAAGGATATATAATCAGGAACTCTAGGGAAACCTGAAGGGCTGAGCTGGAGGGTCTAGAATTGGGGCCTTAACCTGG


GAGTCCAAAAACTTTGCCAAACACTTATTTCCACCTTCCACTCCTCCTCCCGTGCCCACCCTCACAGAGCAGTACTTGGCACCCTAG


ACAAATACTGCCAGATCTACAGACATCTAATGTCTGCAGATACCCACTCCCTGCCTAGCCTCCCTAATCACATAAGACTGGGACATC


TTCGAAGGCAAGGATACCCCTTGTTCTTACTCATCCTTGTTTCTGCAAAGCCCACCTACCTCAGGGCCTGACTCATTGTGGGTCATT


CAGTAGATGTTTGCTGAATGAATAAACATTGTTTGTCTTTTGTTCTTTTAATGAGTAACTGCTGTTTCCTTTGCACCCCTCCCCAAT


ACATTTTTCTCTTGGCTGGCAGCTCCTTGTCTGCTTGCTGAAGATAGAACCGCAGACCACCTGAGCACCCCCTGCCTCCTCAGCTGC


TCACTGTTCTTCTGCATGTGGCCTTCAGGACCTCTGCCCAGCAGTTGTGGCCCATGTCACCCTCTCTGCTGTTGTCACCAGAAATTT


ACCCGCACTGTACCCTCTGGTCCTTCACAGCTCATTTCTCATAATCTATTTTAACAACAAAGTTTGAGAAGGTTAAGAATACAGGAT


GGTAGGAGGTGGAAAAAACAGTGGGCGTGAGCAGTAAGTCGATATGACTAAGCTGAGACTCTTCTGAGTCTTCTAGATGGAAGGGGA


ATTTCTCCAGAGTTACGGGCAGTTACCACGTTGCCTCATGGTCTTGAGCCCCTCTTTTAAAACCCCTGTTGTCTACATTAAGCGGAA


GTCTCCCCTTGGCTGCATTTTGATGTCACTTAAAATGTTGCTGGGGCCCATGCTTCCTAGAGGAAGGCAAGCACAGCTAGCATTCCC


AGGAAAGCCCTCAACTCAGGGGTTTCATTTTGTTTTTATGATGGGAAATAACTTTCATTTCGCGGTCACTGCCCACCCCACTACTTC


CTCTTTGACCCCTTCATCTAAGATGAACACATCTGTTATTTTACCCTGTATAGCAGGTGCAAAAGAGAATTAAAATGGTGTCTGAAT


CCATAAAAGGAATATATTGCATAGAGAATCAAGGCCACAGTAACAAGTGACAGGCGATCTTAAAATATTGGAATAATCTATCTTTCA


AGTTACAGAAGCTTACTAGAGATAGGGGCAGGTCATTGTTACAAGCATCTGGCAGTACATTAATCATGAGAAATTAATTAGGCCTTA


ATGTGGGTCTAATGAGAAATCCTTATTATCCATGTTTGCTTATGGGCTTTGTTGGTTAATTATCAAATGGAACACTAGAGACCCTAA


AATGTGATTATAAAATGATTTTTAAAAGTCCTTTCTTGGAGTGTAATATTCTATTAATGAATCAGCAGAAACTGAAGATTATCTGCT


TTGGAGATGTGTAACAATCCAATGTAATTACAAACCTGTTTAGAGAGGAACCATTTAGCTATATATGATCAAAATAGCCCTTATAAC


TGTTCTCTGTGTATGTGTCTTTTATCTTAGTTTTCTGTGTTCCTGGGAATTATTTTCTTCCTGGAGCTCACTGCCGGAGTTCTAGCA


TTTGTTTTCAAAGACTGGATCAAAGACCAGCTGTATTTCTTTATAAACAACAACATCAGAGCATATCGGGATGACATTGATTTGCAA


AACCTCATAGACTTCACCCAGGAATATGTAAGTTTAAAGTGGTTTGTTTTCAAGTTGAAAGTTCTCTGAACGATGACCCCAGTGAAT


TTCATCCCTCCTGGTTTCTGCATCTGCCAGCTGGAAACTACCTGACTATTCTGCATGGGTGTTTGTTTGTTTGTTTATTATTTTCCG


ACTTGCTCTGTGACTTACAGGATTTGTATTCTAAATGGAAATTTCCTATTTTCACTTGTTTCAACTTCTGTTAAGTTAGAGGAACAA


AGAAGAAAATGCTTGAGCAAAACGTTATAAACATGGCTGTCCTTTCCTATTTGCATTTGAGGAACATTGTTTTGCTCCGGGTTTAAA


GTTTTCTTTGGTTATTAAATATGGATTCTTTCTTATCCCTTGCCCCCTTTTTTGGTAATCCTTGATATTTCACAGCTCATAATAATC


TACTTATCAACAGAATAATTTGCCACAAAGTTCCTAAAATGTGCCTATCCAAATATTATTATTGCACATGCAGTTAAAAGCAAAAGC


TTAGAAACTCCTAAGTCCTAGTGGCTTCTAACAAGTGAAGAATCTGTGCAGTGGAATCCGGGCCACTCTCTCCTATCCCTGAGCATT


GGAGTCCAGGCCACTCCCTCCCGTCTCTGAGCATGCCTGTGAAATGGCTCTTTCAGTGCCAGCAAAGCAGCAGATGTCCCGTTTCAC


TCAGAATGCAAGGGACCAAAAGACACAGGTCTAGTGCCAAAATCTGATAAGGGACCCTGGGCTCACAGGACCTTGACCTATTTCCCC


AATAGCAAAATGGAAATAATACTAGCTACTGTCTAACTCACAGGGATATTATGACACTAATGAGACATACATGTTTTTATATTAGGC


TAAGGTGTTAGGGTCCTACAAACTTGCAGGTCTTTATATACCTGCACTGAAAAGTCGGGTAGGCTGAGCTTGGACTTGGACAGCGGT


GTCTGTGGCATTCATGTATATGGCAGGACCGGAGGGCAAGCAGAAGCCCAGTGAACGGTAGCCTTCTTGGGGTTGGATAGTTGTCTG


CCTGTGATGAAGGGAGGCAGCAGCCATGTTGACACTCTTTATGAGGGAGGCCATCCCCTTCCTTAGGCACTCAGGACTGAGCAGGGT


TATGTGGTTTTGTTCAGTGGCAGCAACATTTCGTCCTGGAGTAAGCTGCCCCTTAAGTGGGAAATTAAGCCCTGATTCATGTCCTCA


GCCGACTTCACTGTTTTATTAGGTCCTAATGGGTGCAGGCTCCCTAATAATCCCTTTCCTGGCATTATTCCTGACTAGTTTGCATGA


CACATTGATGGAGCTTTGTGGACACACCTCGAAATGCATGACCCAAGCCCTGGAAGGACCATGTTGTCTTGGGATGCTGTGTGCTTT


AAACGGAAATACTACAGTTTCATGTGATTTTCTTTTTGCATCATGGAATGTAATGTTTAGAAGTAGCTGTTGGTCCGGAAGGTCTTC


AAATGGTTGAGACTTGATATTTATTTAACTCAGAGAAGTAGAGAAAGTGCATCCCAGGGAAGTGAGGAAGGGGCTTGTGTAGTAGCC


TTTGACTCCGGCCCCATTTAAGAACCACTGAATTTAACCGCTTGTTTTAATATATTTTAATTGGAAGACTGACTTTTTAAAGTTGAA


AATGTAAAACACATGCACTTGTTTTTAAACAAACTCAGAGTAGAAACAAATATGATGAAAAGTTAACCTCTAAAATTTTTGGTGGTA


ATGGATATATCAACTATATATCCATTGATTGTGGTGACATTTTTGTGATGTATACAGATGTCAAAATTTATCAAATTGTATACTTTA


AAATGTGCAATTTATTGTATGTCAGTTATACCTCCATTATTGCGGGATCTGGCCAGCAGCCTGCAATGCAACAGGGATCTCTCTGTT


CCCAGGCGGATCGGCAGGTCGAGAAATAATAGACACACACAAGATAGTGAAAGCTGGGTCCAGGGGGGTCACCGCCTTCTGGTCACG


CAGTGCCAACAATGCACTGGATATACCAGAATTTATTATTAAGTTTAGTGAGGGTGGGGGTAGGTTAGTGAGGGATTTAGGTCATTT


GATTATGAGGTGAGATGGTCACATGGGGATGAAGTAATTCTTTAACATAACATCTGTATGCAAAAGTACAGTATACAGGGATAAGAA


TTTACAATATAGTGTGTGCTTCAGTAATTTCTAACAGAGCCTTAAAACAGAAACACAGTCTTTCCACAACCTATGATTAGCAAGATA


TTAGTCAGCAGTAACAGTTGCAGCAAAAGCCAGTTACAAACAATCCATAGAAACAGGACGTGAAGCTACACAACCAGTTAGACCAGA


AATTCTCAGAACGGAGTATGCCTTAACCCTAAAGAGGTCTAGAAGAGCCGTGGCAAGATGAGGGCATTTATAGCCCTGTCTTATACA


TATGGACAGGTGCCCCTCATGTGTCTGTTTATAGGCTCTCCACAAAGGTCGCATTCTATTCCCAGAGCTATGAACATCTGCTTTTCT


GGGATAGGAATCTTGGTGATGTGAAACCTCCCTGACTGCACGTCCATTCATAGGCTCTCTGCAGGGGGAAGCACATCACGCACTGTT


GGCTCATTCTGGCAGTCCAACCTGGCATTGTCTTTACACAATCCTGCATGCAATTTTGTATTTCCAGTAATCAGGAGCATTTCATCT


TTTATTCCATAGCAATAGTTTCAGGGGGTCTCCCTGCGCTCCATAAAACAAAACAGATCTTTAAAAAAACTATTAGAATGTAGAGAT


CAAAACTTTGAAAAAGTAAGCTATAGTTAGCCCACCCATAACCCCAGTTGCCTCCTTCAGTCACTACCACTGTCGTTAGTGTCTTAT


TTACCCTTCTAGAATGTTCTTGTTTCTCCTTCTAGAATGACGTGCCCAAGCCAAACAGATCTTGTTCTAACTGAGCCCTGCTGTACA


GCTGCTCTGCCCTTCTTCCACCTAACACCACAGGTCTCATCAGTTGTTTAAATCACGTGCCAACACATCCCTACAAACCTTCAGCCC


TAATTAATTTGGAAGATTTTATATGGGCCATTTAGGTTCAGTTTGGCTTAAAAATAAAGTCTAGGACAGAAAAGAAGGTCAGAGCTG


GCAGAAGCTGGTGTCGTTCGGCGGGTGTGAGTGTAGGTGACTGCTTGCCTCCAAGTTGGGATGTTCTAATTCTTTCCTGTTTGCTCT


AGTGGCAGTGCTGTGGGGCTTTTGGAGCTGATGATTGGAACCTAAATATTTACTTCAATTGCACAGATTCCAATGCAAGTCGAGAGC


GATGTGGCGTTCCATTCTCCTGCTGCACTAAAGATCCCGCAGTAAGTGAATGCCAGCGAACTATTGGCCTACTCTGTACATCATGCC


GAGAGTGTGCATGGGACGAGCAGAGTGATTTTTTGGTTGAACCCTCTTCTTACCTGGTTACTCGTATTTGTAGCTCCTGTAGGGGGT


TATGGTGCTCAAATCTTCCTAGTAGGAGTAATAATTGCTGGCATTAATTTAGCAGTGTGTGCTGGTTCCTATTCTAAGCCTTTATGT


GTGTTGGCTCATTTAAGTTGGGCACATTCCTACTGGCAGATACCACCATTACCCTCCCTTTTCAGGGGAAGAAATCAAGGCACATGA


GGTGTAAGTGACTTTCCCAAGCTTGCACTGCTAGCAGGCAATGGAGTGGAATATGAGACCCAGGCAACTTGCCTGTATCATCTGTTA


CCCTTTCTTCATGAGAAGGGCAGGCTCATATGAGAGCTCTCTGCATTGGTTTGGGGTTAGTAACCCTTTTCTTTTTGGCTTAGTTCT


AGGGGAACTATTAGGAGTAGCAGGAGAGTTTGAGACAAGATAGGCCTGGACTGCTGTGTAGGAAGACCACAGCTGCCCAGACTCCTG


AATGTCATCATGACTATAGTCATGCAGTTTGCATTTTATTATAAAAAAGAATAAAATATAAAATCTATTTGTAAGTCACTCACTTTT


GCCACAGGTTTGATTATATTTTGTGTCAAATCGTGCCTGGTATATAGAATGACTTAAAATGCAATTCTTAAGCCAGGCATAGTAGTT


CACACCTGTAATCCCAGCACTTTGGCAGGCTGAGGTGGGAGGATCCCTTGAGCCCAGGAGTTAAAGACCAGCCTGAGCAACATAGTG


AGACCCCATCTCTACAAAAAAATTAAAAAATTAGCCATGTGTGGTGGCACACACCCGTGGTCCCATCTACTCTGGAGGCTGAAACAG


GATCACTTGAGCCCAGGAGTTTGAGGCTGCAGTGAGCCATGATCATGCCACTGCCCTCCATCCTGGTGACAGAGTGAGACCACAATT


CTTTTTTTTTTTTTTTTTTGGTAACTCTCTAGTGTTAGAATGACAAACATGAGAGGTTACTCCACGCATCTCTGTGTGCTCCTAGCT


GCAGAACCCTTCTGGGACTCCTCAACTGTTCTCTGGCCCTGCAGTCTCCAGATGTACTCCCCAAGGCTCGCCCTTACCCCTCAGAAG


CAGAGCCGAGTGGGTGCTGATGAGCTCAGTGGGGATGCTCCTTCTTATGGTGGAGGCTGTGGGGCTCTTAAAAGGAGCTATGGTCTT


GGAGTGGAAAAGCAGAACTTCCCTGTGGGCTTCCTCCAGGGGACCACCTCAGCTGTTTCTCTTGGTCTGAAAGAGGAGACAAAGTCA


CTAAGGACTGTGCTGCCCCGCCAGCTGCCCTTCCCACCAGCTCAAACCTCCTCTCCCTTCTGAGGAGAGCCACATGGCAGCAGAGTG


CCCACTCAGAGCTTGAGGGGCTCATCCTGGTGGCCTTGCACTGGCCAGCGGGTGCCGCACAGTGCGCCTCCTGTCGCCAGTTCCTGT


CCCACATTAACACTCCCTTGGGAGAATTCTGTATTCTCAGAGGCATTAATGCTTCCCCTTTCACCTACAGATCCTCTGGGCAGAGCT


AGCTCATTCCTTGCGCTCTAAGCTAATAAAATCTGCCCCACACCCCGCAGAGAAGGAAAATAAACAACCCGAAAAAGTGGAACCATG


TTTCTGATCAGACCCTGTGAGACGTCAGGTTGTCTGTGTGATTATGTGGTCGGGGCATTGTTTTGTTTTTTAATTATTAAAAGCTCA


TTGAAAAACAATTTAAGTAACATGGAAGTACATAGATTAAAAAGTAGCAGTCCATCCAAAAGAGCATACATGAAGATTCACTGTGCC


CTTTATGTTTTTTATCTGTGTCTCCAGTTCCCTAAATCCCATAAGCTTCTTGAGGTTGGCACCACTTTGAATCTTGAGCCTCCTGTG


TGATAGACTTGCTGTCTTTTCTGATATTCCCCAAGCCTTAGTTTTCCTTATTTGTAAAATAGGGCATATTTTAATACCTACTTCTGA


AGATTGTCGCAATAATGACATGGGATCATGTATATAAAGTGTTTAACATAGTGCTGCAGTCTTTGTGCCCAGATACACATTTTATTA


CTAATGCGTAACAGAAGTCTTCTGCTCATTTCTAGGTGGGCTTTCTGTCTAATGAGTAAATTTCACTTTTCTCTTTCCTTTCTTCAC


CAGGAAGATGTCATCAACACTCAGTGTGGCTATGATGCCAGGCAAAAACCAGTAAGTGGAATCTCATGTTGTTGCTTAGCACGAAGG


GTGTTGGAGGAGCTTTGGCCTGTGCCTGGTGCTCTATCTGTGACAATGTGCTCTCCTCTTCTCTTGTGAAGGAAGTTGACCAGCAGA


TTGTAATCTACACGAAAGGCTGTGTGCCCCAGTTTGAGAAGTGGTTGCAGGACAATTTAACCATCGTTGCTGGTATTTTCATAGGCA


TTGCATTGCTGCAGGTAAGATAAGGGTCCTTTATGGATATCACAGGGAAATAATGCCCTGGGAGAGCCCTTGCCAGGATCGGAGCTT


TGCTTAAAAACCTTGATTGTCATAGTTTTTAAGACACATTGGAGGGCTGAGGAACAGACCTAAACGATTTGGTTTGTGTTTTATTTT


ATTCATTTATTTATTTATTTTATTTATTAATTTTTTTTTGAGATGGAGTCTTGCTCTGTCGCCCAGGCTAGAGTGCAGTGGCATGAT


CTTGGCTCACTGAAAGCTCCGCCTCTTGGGTTCATGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTGCCCGCCA


CTACGCCCGGCTAATTTTTTTGTATTTTTAATAGAGACGGGGTTTCACCGTGTTAGCTAGGATGGTCTCGATCTCCTGACCTCGTGA


TCCGCCCATCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGTGATCCACCGTGCCTGGCCTGATTTGTGTTTTATTAAAGCTCTGAG


TTTAGATGCTACTATCATGAAATACTTTAGGAAACCTTGTCTTTTTCTAAGATGGAGACATTAATTAGATAGTGGTTGCCTACTGGC


ATTCCATCGTTTACATGGGCTCAAAAATACTGCATTGTGGCAACTGAGTCAAACATGCATAGTTAGAAGTAGATCTCAGTGGTGACG


TTAAGGTTTTGGGAAGTTTCACAGAGATGTCATACCCCTTTCTCTCCCTAAACTACCTTGCCAAAGTGCTAGTGAAGGAAGGGAGCA


CCCACTTTTCCTCCTGGCCAGTCTTAAGAGCTGGACTCTTCATGTTGTTGGTGTGATACTTTCCAAAGAGCACATAGTTGAAACAAA


TTAAAGAAGACCTAAGTAAATATAAAGATATCCTGTGTTCACAATTGCAAAACTTCATATTATTAAGGTAACAACACTCATCAAGTT


GATCTACAGATTCAGTGTAATCCCTATCAAAATTGTAACCACCTTTTTAGCAAAAATGGACAAGCTGATCCTAAAATTCATATGGAA


AAGCAAGGGACCCATAATAGCCAAAACAAATTTGCAAAAGTAAAACAAAGTTGGAGAATTCACACTACCCAGTTCAAAACTTAGTAC


AAAGCTATATAGTAATCAACATAGTGTGTACTTGAGTAAGATTAGCCATATAGAGAAGTGGAATAAAATTGAAAAATCAAGAAATAA


AACCAGGCCAGGTGTGGTAGCTCATGGATGTAATCCCAGCACTTTGAGAGACCAAGGCAGGAGGATGGCTTGAGCCCAGGAGTTCAA


GACCACCCTGAGCAACATAGCAAGTCCTTGTCTCTACAAAAAGTAAAAATAAAAAAATTAGCCAAATGTAATGGCACATGCCTGTGG


TCCTAGCTACTCAGCAGGCTGAAGTGGGAGGATTGCTTGAGCCCAGAAGGTTGAAGCTGCAGTGAGTCGTGATTATGCAACTGCACT


CTAACCTGGGTGACAGAGCAAGACCTTGTCTCAAAAAAATAAGAAAAAAATATATATGATTAAAAAGAAGAAATAAGGCCGGGTGCA


GTGGCTCATGCCTGTAATTCCAGAACTTTGGGAGGCTGAGTCAGGTGGATCACTTGAGCTCAGGAGTTTCAAAACAGCCTGGGCAAC


ATGACAAAACCCTGTCTCTACAAAATATACAAAAGTTAGCTGGGCATGATGGCGCATGCCTGTGGTCCCAGCTACTTGGGGGGCTGA


GGAGGGAGGATCACTTGAGCCTGGGAGGTTGCAGTGAGCTGAGATCATGCCATTGCACTCCAGCCTGGGTGACAGAGCAAGATCCTA


TCTCAAAAAAGAAGATGAAATAAGCTCGTACGTATATGGTCAGTTGATTTTTGACAAGGGAACCAAAACCATTCAATAGGGAAAGAG


CAGTCATTTCAACAAATGGTACTGGGAAAACTAGATATGCAAAATAATGAATTTAGACTAACTCACACCATATGTAAAAATTAACTC


AAAATAAAGCAAAGACCTAAATATAAGAGCTAATGCTATAGAACTCCAGAAGAAAACATAGGCATAAATATTTGTGACTTTGGATTA


AGCAGTGTCTTCTTAGATATGACATCAAAAGCATAAGCAATGAAACAAATGTAAATAAATTGGACTTCAAAATTTAAAACTGTGCTG


AAAATGATACCATCAAGACAGTGAAAAGATAACTCCTAGTATCTAGAAAAATAAAGAACTTTAAAAGTCAACAATAAAAAAGACAAA


CAACTTAAAAATGGGCAGCCAGGCATGGTGACTTGTCCCTGTAATCCCAGCTGCTTGGGAAGCAGAGGCAGGAGCCTGCACTGAGCT


ATGATCACGCCACTGTACTCCAGCCTGGGCAACAGAGCAAAACCCAGTCCCTTAAATTATTAAAAAACAAACAAACAAACAAAAATA


CGGGCAGAGGATCTGAACAGACATTTCTCTAAAGATTAAAATTGCTAATAAAGGCCGAGGCGGGTGGATCATGAGGTCAGGAGATCG


AGACCATCCTGGCTAACAAGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGCGGTGGCGGGCGCCTGTAGTCCC


AGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAAGCGGAGCTTGCAGTGAGCCGAGATTGCGCCACTGCAGTCCGC


AGTCCGGCCTGCGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAATGGCTAATAAGCACATGAAAAGATGCCAACGTCA


GTAGTCATTAAGGAAATGCAATTCAAAGCCACATATTTCATACTCGTTAAAGCGGTTAGAATAAAAAAGACAGACAATAACAAGTAT


CGGCAAGGATGTGGAGAAAACGAAACCCTCATATGTTGCTAATGGAAATGAAAATGTTGCAACCTCTTTGGGAAACAATTTAGCAGT


TTCTCAAAAGTTAAATATAGTGCTACCATATGAGTCAGCAATTCTACTCCTAGAGGAGTACCCAAAAGAATTGAGAAAGTGTTTACC


CAAAAACTTGTATGCTCATGTTCATAGCAGAATTATTCATAATTGCCAAAATGTGAGAGCAATGCAAATACACATCAACTGAGGAGT


AGATAAACAAAATGGGGCATATCCATGCCATGGAATATCATTCAACCATCAAAAGGAATAAATTAATAGCACATGTATATGAACCTT


GAAAATATTTTGCTACATGAAAAAGACAGCCACAAAAGCCCCATATTATATGATTCCCTTGATATGAAATGTCCAGAAGAGGCAAAT


CCACAGAGGCAGGAAGTAGATTAGTGGTTGCTAGGTCTGTAGGGATGGTGGGATGGGAATGACTGCTCACAGGTACACGGTTTCTTT


TTGGGGTAATGAAATGTTCTGTGATTAGATAGTGGTGATAGTTGCATAGCTTTGTGAATATACTAAAAGCCCCTGAATTATACACAT


TTCAAGGATGCTTTTTACCACATATGAATTACATCTTAAATTTCAAAAATCAATGATTTAAAAAAATGGGACACAGTGGCCAGGGAA


ACAAGTTACAAGTGTCACTGTTTCACTCACATTTTCTTCCTTTCTCAGATATTTGGGATATGCCTGGCCCAGAATTTGGTTAGCGAT


ATCGAAGCTGTCAGGGCGAGCTGGTAGACCCCCTGCAACCGCTGCTGCAAGACACTGGACAGACCCAGCTTTCGGGACCCTCCCGCG


TGCCGAACTGATCTTCGAGCTGCATGGACCTAATCACAGATGCAGCCTGCAGTCTCGCCTAATGGAGCTGCCATTAGGGGAGTGTAA


AACTGGGAAATGCTGCTCACTGACAGAATTAAAAAAAAAAATAACCAGTATGAAAGTCGTTGCGCCGTGAATCTCTACTGTAGCCAT


GAATTTATGGACAGTTAGATGCTTACCAAAAAAGAAAAAAAGGGAGGGTAGGGGACCCAGATGTACTTGAATGTGCAGAAAATACAT


TCTTGTCCTCATCTTCCGTAATTGGAGGGCTGGGAGAGGCAGCTTTGCTCTTCACCACACCTTGGACGGACCACCTTCTTTCTGTTC


CATGGCCTGAAGGAGTGCATCTCCTCAAAGACTCAGCCCCTCACCTGGGAGGGCAGTGGTTTGTGGGCATCCCTCCATGTACATTTT


AGGAAACACTTGCAACTCTCATCTGAAGAAGAAAACAACTCATCTTTGGGTTCAGATTTTGTGATGGTATTCAGCAAGTCACTTGGG


CGAGCACACTTGGTCTATCCTGGAAAGTCTCCTTATAAGAGAAGTTGTGTATTTCATGTGCACCGAGCAAGGGCATTGGAAGACGTC


ATGAGGCTGTATTTTAGCAGGACTGATCGTTTTTCTAAGTAGACCTGAGCTTTGTTTATCAGTGAAATTCAAGGAGAAAATGAGGTT


AATGAAGAGCTATCAGTTAAATATCCCCTTCTTCTCACCCTGCCAAAATTAGCAGTTGGATTTTTGGAAACTCTGGAATATTCTGGG


TCATTTTGTTTTGTATGTTTGTTGTTTTTCGTCTTCCAAAGGTGAAAGCTATGATACAGTTCCACTTAAATTTTAGTGTTTTCTTAC


TCAGCTCAAGCATTAATTTTTGATTAAGTCTTAATCTGCATGACCTGTGAATCTGAATCCATCATCTCCCTTTCCTGCCAGCTTTTC


TACAAACATTGAAATATGTTATTTGGTCAGCACTTATTTCCTAGGTTCACAGCCTTGGGAGGTTGTGGCATGTCCTCCCAGTCTGCC


TGGGAAGAGACCAGCTGTACCATCCAAATGCTTCCCTGGTCTTGATGATCTCTTCCAGAGTCGATCTGAGTGGCCTTTTCTGCACCC


TCCCCTTCTTTCTCTTTGAATGGAATTAAACCCAATTTGGAAACAACATTGACCCAGTCAAAAGCTTCTAATGGTTTCTTTTTCTTC


CTCCAGTTTTAGTTTGCTTTTATTAAAAAAAGAAAATAGTGCATGGCCATAGCTCCTTCAGTTCTCTTATTGCAGACTAACCATCAG


GATGGTATCAAAGCACAAATACTTTGGAGGGGAATGCGTTGAACTGGGGCAAGTACTCTGTAACACAAAGTGGGAAACCACTTCCTG


GTGCTGCCGCTCCTGCCCCCACTTTAGGTGGGAGGGACGAGTTTTGCCCTCTAGATTTTAATCCAGCTGGTGTCCACCGGATGTTGC


CCTCCTGGGGAGCAGATATCAGTCTGTGGAACTCTGGGAAAACCACAGGCACATTTTTCGGTGCGGACAGATTTGCCAGCACATAAC


TGGGCAGCCAGCTAGAATACTTTGTGGAAATTAAGCGAGGTTTTCCATTTCAGCCCCATGGTGCATGGTGGTGGCCGATGAATGTGT


CAGTCTGCTCAGAGAAAGGACAAAAAGGAAATTATTTTCAAAACTGTGTTCACTGTTTGGGTGTGTGTATGGCTCTGCATGTGTGTG


TTTTTGTCTCTGTATAGGTAGAGGTATTCACATCTTACTCCGACTGTAAGGTTGTCTTACTTCATCTCTGCCCCCACCACAGTTGCC


ATTTTGTAATGTCCTTCCAACATGGAGAAGACACGAGCTCTCTCCAGTTGGCATCATTTGTCTTTTTTGTTGATTGCCTCATTCTCC


AGTGAACTCCATCTGGCCAATTGATTCAGAATCAGGCAAGATCCCTGCCCTTTGGCACATCCACTGAAAGGCCAAACAGCAAGTCCG


AGTGAGTTTTAAATATTAATTAATCACCCTTTATTTTTTACACTTGAGAGTGATTGTAATAAAGGCTGTCATTAATAAACTTGGTTC


TACCT





HUMAN mRNA SEQUENCE: AR28-002.1 (Seq ID No: 53)


CGCACGGACGCGGGCGCTCGCTTTGTGTTCGGGGCTAGCGTCGGCGAGGCTTGAGCTTGCAGCGCGCGGCTTCCCTGCTTTCTCGCG


GCCACCCCGGCTCCGGCGGCCTCGGCGCGCGAGGGGCTGGAGGTGCGGGAGCCGCTCTCCGCCGGTCGGTCCCCGCGCGGCTGAGCC


CAGGCCGCCAGCGCCGCGGCCCCGTGCGGTGTCCCTGAGCTCCTGCTCCCCGCCGGGCTGCTCCGAGCAACGGTGCTTCGGAGCTCC


AAACTCGGGCTGCCGGGGCAAGTGTCTTCATGAACCCAGAGGATGTCCGGGAAGCACTACAAGGGTCCTGAAGTCAGTTGTTGCATC


AAATACTTCATATTTGGCTTCAATGTCATATTTTGGTTTTTGGGAATAACATTTCTTGGAATTGGACTGTGGGCATGGAATGAAAAA


GGAGTTCTGTCCAACATCTCTTCCATCACCGATCTCGGCGGCTTTGACCCAGTTTGGCTCTTCCTTGTGGTGGGAGGAGTGATGTTC


ATTTTGGGATTTGCAGGGTGCATTGGAGCGCTACGGGAAAACACTTTCCTTCTCAAGTTTTTTTCTGTGTTCCTGGGAATTATTTTC


TTCCTGGAGCTCACTGCCGGAGTTCTAGCATTTGTTTTCAAAGACTGGATCAAAGACCAGCTGTATTTCTTTATAAACAACAACATC


AGAGCATATCGGGATGACATTGATTTGCAAAACCTCATAGACTTCACCCAGGAATATTGGCAGTGCTGTGGGGCTTTTGGAGCTGAT


GATTGGAACCTAAATATTTACTTCAATTGCACAGATTCCAATGCAAGTCGAGAGCGATGTGGCGTTCCATTCTCCTGCTGCACTAAA


GATCCCGCAGAAGATGTCATCAACACTCAGTGTGGCTATGATGCCAGGCAAAAACCAGAAGTTGACCAGCAGATTGTAATCTACACG


AAAGGCTGTGTGCCCCAGTTTGAGAAGTGGTTGCAGGACAATTTAACCATCGTTGCTGGTATTTTCATAGGCATTGCATTGCTGCAG


ATATTTGGGATATGCCTGGCCCAGAATTTGGTTAGCGATATCGAAGCTGTCAGGGCGAGCTGGTAGACCCCCTGCAACCGCTGCTGC


AAGACACTGGACAGACCCAGCTTTCGGGACCCTCCCGCGTGCCGAACTGATCTTCGAGCTGCATGGACCTAATCACAGATGCAGCCT


GCAGTCTCGCCTAATGGAGCIGCCATTAGGGGAGTGTAAAACTGGGAAATGCTGCTCACTGACAGAATTAAAAAAAAAAATAACCAG


TATGAAAGTCGTTGCGCCGTGAATCTCTACTGTAGCCATGAATTTATGGACAGTTAGATGCTTACCAAAAAAGAAAAAAAGGGAGGG


TAGGGGACCCAGATGTACTTGAATGTGCAGAAAATACATTCTTGTCCTCATCTTCCGTAATTGGAGGGCTGCGAGAGGCAGCTTTGC


TCTTCACCACACCTTGGACGGACCACCTTCTTTCTGTTCCATGGCCTGAAGGAGTGCATCTCCTCAAAGACTCAGCCCCTCACCTGG


GAGGGCAGTGGTTTGTGGGCATCCCTCCATGTACATTTTAGGAAACACTTGCAACTCTCATCTGAAGAAGAAAACAACTCATCTTTG


GGTTCAGATTTTGTGATGGTATTCAGCAAGTCACTTGGGCGAGCACACTTGGTCTATCCTGGAAAGTCTCCTTATAAGAGAAGTTGT


GTATTTCATGTGCACCGAGCAAGGGCATTGGAAGACGTCATGAGGCTGTATTTTAGCAGGACTGATCGTTTTTCTAAGTAGACCTGA


GCTTTGTTTATCAGTGAAATTCAAGGAGAAAATGAGGTTAATGAAGAGGTATCAGTTAAATATCCCCTTCTTCTCACCCTGCCAAAA


TTAGCAGTTGGATTTTTGGAAACTCTGGAATATTCTGCGTCATTTTGTTTTGTATGTTTGTTGTTTTTCGTCTTCCAAAGGTGAAAG


CTATGATACAGTTCCACTTAAATTTTAGTGTTTTCTTACTCAGCTCAAGCATTAATTTTTGATTAAGTCTTAATCTGCATGACCTGT


GAATCTGAATCCATCATCTCCCTTTCCTGCCAGCTTTTCTACAAACATTGAAATATGTTATTTGGTCAGCACTTATTTCCTAGGTTC


ACAGCCTTGGGAGGTTGTGGCATGTCCTCCCAGTCTGGCTGGGAAGAGACCAGCTGTACCATCCAAATGCTTCCCTGGTCTTGATGA


TCTCTTCCAGAGTCGATCTGAGTGGCCTTTTCTGCACCCTCCCCTTCTTTCTCTTTGAATGGAATTAAACCCAATTTGGAAACAACA


TTGACCCAGTCAAAGCTTCTAATGGTTTCTTTTTCTTCCTCCAGTTTTAGTTTGCTTTTATTAAAAAAGAAAAAATAGTGCATGGCC


ATAGCTCCTTCAGTTCTCTTATTGCAGACTAACCATCAGGATGGTATCAAAGCACAAATACTTTGGAGGGGAATGCGTTGAACTGGG


GCAAGTACTCTGTAACACAAAGTGGGAAACCACTTCCTGGTGCTGCCGCTCCTGCCCCCACTTTAGGTGGGAGGGACGAGTTTTGCC


CTCTAGATTTTAATCCAGCTGGTGTCCACCGGATGTTGCCCTCCTGGGGAGCAGATATCAGTCTGTGGAACTCTGGGAAAACCACAG


GCACATTTTTCGGTGCGGACAGATTTGCCAGCACATAACTGGGCAGCCAGCTAGAATACTTTGTGGAAATTAAGCGAGGTTTTCCAT


TTCAGCCCCATGGTGCATGGTGGTGGCCGATGAATGTGTCAGTCTGCTCAAAGAAAGGACAAAAAGGAAATTATTTTCAAAACTGTG


TTCACTGTTTGGGTGTGTGTATGGCTCTGCATGTGTGTGTTTTTGTCTCTGTATAGGTAGAGGTATTCACATCTTACTCCGACTGTA


AGGTTGTCTTACTTCATCTCTGCCCCCACCACAGTTGCCATTTTGTAATGTCCTTCCAACATGGAGAAGACACGAGCTCTCTCCAGT


TGGCATCATTTGTCTTTTTTGTTGATTGCCTCATTCTCCAGTGAACTCCATCTGGCCAATTGATTCAGAATCAGGCAAGATCCCTGC


CCTTTGGCACATCCACTGAAAGGCCAAACAGCAAGTCCGAGTGAGTTTTAAATATTAATTAATCACCCTTTATTTTTTACACTTGAG


AGTGATTGTAATAAAGGCTGTCATTAATAAACTTGGTTCTACCT





HUMAN PROTEIN SEQUENCE: AP28-002.1 (Seq ID No: 54)


MSGKHYKGPEVSCCIKYFIFGFVIFWLGITPLGIGLWAWNEKGVLSNISSITDLGGFDPVWLFLVVGGVMFILGFAGCIGALRENTF


LLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDLQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNAS


RERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEA


VRASW*

















TABLE 6










MOUSE GENOMIC SEQUENCE: mD28-010 (Seq ID No: 55)



GCATTTCTTACTTACTGAAAGGTAAGGGTGAATTGTCCTCAGTATTCTTCCAGAAGTTTGTAAGAATGATAACTTAGATGATGGGTG


GATGGCTTAAGAAGGGCTGATAAATGTATCCCTTGAGGCCAAGTGTGTACAGCTACAAAAGGTGCTTGTCCCTGGTGTCCTTAGCTT


TTGGGGAGGACACAGTTCCTTTCTCTAATAGTTATTTCTCATGAGTCTGTATTTCAGACACTCACTGGATGAAAGTGGCTTTTGGTC


GAACTGAACTTGGAGTGGAACTAAGGGAACATTGGGTTCTCTGAGGTGTAAATGAGTGTGAGCACCTGTCATTAGGGATCAGCATCT


AAAACTGGTCTGAGAACATTTCCAGAACTATGTTGTAGGAATTGGAGTTAGAATCCTAGTCTCATAAGTTGTGGTGTCTCTCACATG


TCTTTAGAGATCATTCAGTCTACTTTTTGGAGGAGACAAATCCAGTGTTGGATTCTTAACACTGTCTGGAACGTGGAAGGGTTGGCA


CAGAGGAGAAAGGAGACTTTTAAAGAAAGCACTAGAAGAAGAGCGAAAGGGAGACCAGTCCCACCTTGCAGGTGGGAAAGGGAAGTT


GCTGTGGGGGTGGGGTGGGGTGCTTCTGGTTCCCTTCATAGCAGATGAACTGTCTGCTAATGAGGGATTCTCAAGATATCATATGCG


CACTGGGAATCTTCATAGTTTTGGCCATTGCCAGTGTGTTTTGATTACAGGTGACTTTATAGAAATGACACAGATGCTCCCTGTAGT


AGGGTGTACCAAGCAAACTGTTTGGGCAATACTTTCTTTCATACTTTTCTATAAAAATGTAAGTAGCAAGTAAGGCATTGTTTAAAA


GAAGAAAGTGCACACTGGGATAACAAGAAAAACAGTCAACATTGAGGTGTTCTAAAGAAATAAAAGGACTCCTTTTCTGGAGAGTCT


ACAGTTAACTGGGGGACATGCATTTTATGAGTCTTTGGGGTTGGTCAGTTGGGTTGGGCCCATTTCATCATTGATTGGCTAGAGCAC


ATGAGGCTGTGCACTTATGTTCTCTGAACCTTAATCTTTTTCATTTAGATAACAGATAATCTGCCCAAGTGGGTGACCATGAGGAAC


AAATGCATAGGTAAAGTGCTTGCTGTAATGGTAGCCCCTCAGTGAAGGTTGGCTTTCTTTTTCAGGAGAAAGTCCAGATACTGAGTC


AGGTCAAGCTGAGGTGTTACTGTTTGCTCTGTAAGAAAACAAAAACAAAAACAAAAACACCCGCCTTGTGCTTATGATTCTCCTGCA


TGTTAGGATTATATGTGTGTACCACCACAGCCTTCTAGAAAGATCATTNNNNNNNNNNNNNNNNNNNNCATCCCCCCAAGCTATGTT


AAGAACATGGGATTGGACATGATAATAAGAATGATAAGATGATTGGGTTCTGATGAATAATATTCAAAAGTCAAAAGTCCCCCAGAC


AGTTTCCATATAAGTCTTCAGGTTTGAAGATCTGAGGGAAGATCTGAGCTCTGAGGGAAGTCATTGCTGTTGAACATAAATACTGCA


TTTGCAGTATTTTCTTCTTACCAAGGCCAAAGTTTGTCCTGTGTCCTACTGTCAAAGGCAGGATCCAGAAAGAGAACCTGCTACACT


TTTGTGTTGGGAGAGGACTCTGGGAAGCAACCCTGTGCATCCTTTTGTTCCTGTCTCAGAAGGTCCACGAATAAATGCACATATGGG


TGTGGAAACACTTAGTCATTTGTTGTCATAAAATTGTGTTCATTCAGAAACTTCTGGTGTTTAACTTAGAATGGGTCTAGCCTTTCT


GTGGCCAACTCATTGATTCTTAAACAATGGAAGATATGATGAATTTTCTTACGTGTCTGACCCATCTGTCATTTGTAAGTTGTGATA


ATGAACATGAATATTTACTTCAATTTGAGGCATATTAACTTACTACAATAAGACAGTCACCCAGTGACTCAATTATTAATTGTATTA


AAATATATATTTTCATGTACATAACACTTAACAGATTAAGCTATATTTCCTAGTTGCATAGGTGGTAAAGAAAACCTTAACTTTTAA


AAAAAATTCTCTAATAATGACAATATGAATTTATCTAAGATATCTAGATTCGATACTTTCTTACCATATTTAAAAGGTTATCACTTG


TTGGTATGATTAAACCCAGGGCCACAATCATGGTAGGCAAGTGCTACATGCAGCTCTGGAGTGAAGAGAATCAGAACTCTAGGTCTG


TGTTTTGGAAGATGTTTAAAGATGAACATGTTCCTCACATGCATGCTGGCTACACTGTGCTTCCGTCTTTGATCTCTGATAGAATTC


AGTCAGTAAAGCTTTTTCCTGGGCTTAGTTTCCTGCCTTGTATGATAAGGGGATCCACACCACAGGATTGTTGAGTGTAAATGAATA


GATTTTCTAAGGTGCTTAGCTCTAGCAAATGTTTAGTAAATGCAAGCTTGGAAAGACATTCGGTTCATTATACACCTTTAAGGGATA


AGGTGCCCTTTATTTGGTAGAATTAAGGTAAGTTCATTTTTGCGTCCTGTCCTCTGATGCATAGTCATCATCAAGGTTTAATTACAG


GAAGGAGAACGTTAACTTCTTGTTCTTCAGCAAGATTGTGATTACAATACTGCTTCAAAATGACCAGTGTCATAGCAAATGGTGACT


TTTTTTTTTTTTTTTTTTTTTTTACATCCTTCAATGTCTCAGTCCTGTGGTATAGAATGGAATTTAGATTGATCTCCTATTGAATTT


CTGGGGTTAGCAAGTGTGATCATATTATCTCCATGGTATGTTTAACTTTACATCTTCATGTACATGAAGAAATACTACTCCATTCCC


AAAGAGACTGTCACAAAATTTTTAATCCACCTTTTATGAAAAACAGCAATCCTTATCCTGCTCTTTAGGTCAGAGAGGACCCTCATG


GTAGTGGTGTGCTATATTTGGAGTCCTCCTGCATCTCTCCCAGGGCACCTGGGCTGTGAGTCTGCTCACATCAGGGAATGCAGACCT


AAATCCTGTCTCCTGGGGTAAGAAAGGTGAGAAGCTGCTGCTATGCCCATATCAAAGCCCCCAGCCCTCTGAGGACTTGGGGCATTT


GTCCTTTTGGGGCTAGAATATTAGATACTTTATACATCAGTTACTTTTCTGTGATAATATATCATGGCCAAGACAGCTCAGAAGGCA


GGGTTTATTTGGGTTTATGGTTTCAGAGGGAGGGTCCATAGTGTGTGTTGGGGGGCGCACATCTTCAAATGCAACCATGAGCCAGAG


AGTAAACCGGAAGTAGGGCAAGGCTGTGAACCCGTAAATCCCACTCTGGTGTGCTTCCTCCATCAAGGTTGTATCACCTTCCCAAAT


TATACACCAACTGGGGATCAAATGTTTGGATACCCAGAGCTCTGGGTTTCTCCTTCAAATCACTACAGCTAGCCATCCTGTGAGCCT


CTGAGTGGAGGGCATTCCTTCCCAGTCTGCCCAATCCTTGTCCAGTGTGTGGGAGTGCTAGGTAGAATGAAAGCCAACCAGGAAAGA


ACATGACAGTGGTTCTTAAAAGATTCCCAAGAGCTCCTTCTTTTTCTTTAAAAAAGATAATTATGTTGATAATTGCTATTGCAATTA


ATTATACAAAGCTAAATAACTTTAAGTTATCCAGGGGAACTATGTATCCTCTTGTGAATTCATGTATCCCATCATGAACGTACTGAT


AAAATAAAACCCTTCAATTTTGGATGCATAAATCCAGATGCTCGTATGCTTTTCCTCTGCACCAAGAAGCTTATATTTTTGGTGGGG


GGCCTGGGGTAGATGTGTGGCTGTCGGTTCCCTTTCCTTCCTCTTCTTTTCTTTTCCTTAGCTTTAAGAACACCAGACTGCTTCTCA


CCTCAGGGGGAGACATCAGTCTGCAGTGTGAGGAAGCAGACCTCATTTTCTGCCTGGGTGCTTGTTTCTAGCTTATTAAGAGCTGCT


TTAATTGGGTCCCTAATTTGTCAGGAGTACAAATTGGTCAGCTCCTACTTAAGCAATGTAATTGGTGCCAGTGATTTGTGAGCCAGA


GCAGAAGGATGGGCTTGGGTGACCTCGGCATGGCTTGGTGAATAATGGTGTGAGCCAATTTTTAATCTGATCTTTATTCATATCTGG


CCTTGCCTTAGAATTTATGCTGCTCTTAGCAATATACAATGCCGCTGTAAAATGAATGACACACAGACTATGAGGCACTGCTTAGTC


CTGGTGACATTGTGAGTCCAGTCACATCCTTTCTTGCCCACACTACCCTGTAATAAACTAATTTTGTGTCCTTCTTCTCCACCTCTC


GTGCTTTGTGCATGGCTCATTCCTTGGTGTTGAATGAGTTATTTCAAAGCCCATTGGTGTCCCTCTTATTTCCATATATATATATAT


ATATATATGTGTGTGTGTGTATGTAGTGAGAGCACAGGCCTGGGAAGGAACATGGCTATGAGACCTTGATTGGCCTCGTCTCTTAAC


TTCTCTGACTTTCGCTTTTTGATATTTCCATCTCAAATGCATGTGCTCTTTGCTTCACAGAGCTCCTCTGGGGGGGGGGGGAATCAT


AAGATAATTCAATGAAAGGCTCAGCACTGTGTGGCTTGTTTCCAGTAAGTGCCGCTTCACTGCCTTTGTGCTGTGATCCTGTACAGT


CTGCTGGGACATCTGTGACTTTCAGGCTATGGTGGACTGAGTGAGGGCACCTTCCCAAGAGAGTTCCACATTTGAGGTTAAGGTCCT


GATAAGCCACCTGCTGGGTAAGGTGACTGAGGTCTTCTCTTCAAAACTCATTAAGAGCTCAGAGCCTTTGATCTTTGTCACTACAGG


TAGCTTGGCCTTTCAGATAGTCACTATAGGAACAGCCAGAATTGGTCTTTGTACCTGAGGGAGATGCTGACAAAAAGCAAAATTTCT


AAGCAGATGGTTGGGTCAACCCTTCCAGGAATCTCAGAGGAGAGAGTATGGAGTTCTCTGAAATGGTCAACTGAGACCTGTCCAGGT


AGTGTCTCCAAGTTGTCCTGTGACGCAGGTGTCCGGTGGCTTTAGTCAGCTTAAGTTTTAAACAGTGGTTTCCAGTCAGAGTCCTCA


TGACCCGTGGCCAGATACTTACCTAGTGAGTCATGTTTCCATGAAGAGGAAGTGAAAGCAAGACCTGTCTGAGAGGGGCATAACTGT


ACCTAGCATTGGTGAAGTTTGCTCTGAATCAAGGCTTTGCCTTGCTGTTACAGTTGTGTGTGTGAGTGGGGGGTGGGGGGGGTGGGG


TGCTGTCAGAAAGTGGGCTGAAAGGAGACATCCAGAACAATACTTTAAGTTCTGACTGAGAAAGTGCAAATTGTGGCTAGTACATGC


TGTCTGATATTAACGTCACTCTCAAAGATGGATACTCTTCGCTGCCTTTTGCTTTAAGGAGAGTGACCAGGCCCCTAAGTCAACACA


GAAGCCTGGCCCCAAACCATCAATCTTCAGGGTCCATGCTTCTTACAACTTCATAGTGTGGAAGATTGCCCTCAAACAAGTCATGGT


ACCCTTTCAGAAGATGTGTCAAGTGGTTATTGTTATTTCCCACAGGAAGCCAGCCTATGAGTGAAAAGACCATAGGCACATGACAAA


GAATTGGTGAGACCATGGAGTTCTCTGAAATGGTCAACTGAGACCTGTCCAGGTAGTATCTCCAAGTTGTCCTGTGACACAGGTGTC


CGGTGGCTTTAGTCAGCTTAAGTTTTAAACAGTGGTTTCTGGTCAGAGACCTCCTGACCCAGATACTCACCTAGTAAGTCATGTTTC


CATGAAGAGGAAGTGAAAGCAAGTTTTGATTACTCTGTGTTTGAACCCCTGACATAGACCTTCATTTTGTTAATGTTGATTTCTCTG


TCATTTTAACTTTTAATTCTTTTTTAATTAGATATTTTCTTTATTTGCATTTCAAATGTTATCCCTTTCCTAGTTTCTCCTCCAAAA


ATCCCCTATCCCCTCCCCCTGCTCTCCAACCTACCCACTCCTGCTTCCTGGCCCTGACATATTCCAACTGTTTCTCAATCATTTATT


GGAGCAGGACTCTTACTGCATTTAACAGTGAAATAATCCCTTCCATCAATTAAAAGAAAGAATCAAACTTTCAAGATTAGGCTTTAA


ATCTCAAATTAGTGAATAGTCATTTTATGAGAGTAATATCTATTCTGAAAGCTTATAGATGCGAACCAATTACTCCGCTTTCCATCC


ATATTAGATGATGGTGGATGTAGAGCTAACAAGCATCTGTTGAGATCTTAATACACGTGAGCTATGGTATGGCGCATTCTGGGAGGT


TAGAAAGTAACGAGGCCTCTATTCCACAGGGTTTTAGTTTTTAGTAGAGACAGTAACTCTGATAAAGATAAGTAAATAAGTAAGTAA


AGGATAAAAAATAAAAGATAAATAATAAAAATAGGAAGTTCAAAAGGAAGAGGCTCTGTTTGGAGATCAAGGATGACTTCCTGCAGG


AGGCTGGGACAGGGTCTAGCTCTGCAGTGGCAGACCTGTGCTTCTCTTTGGGAGCTGAGTTCCTGTCTGTTTAATGTAAGAAGTTTC


TAAGTAACTGGGTGAGCTGATGGGTGGAAAGCAGAAGCAGTTGTGAGAGAAGAGCTCCCAGCAAGGCTTTGTTAAACAAATACCTGC


TGCTGTGCCCCAGGCCTGTGGCAGCTGGGGGAGAGCCACTAGTACAAGACACAGATCCAGTGATCTGGGCAAAGGGCACAGTGGCCG


GGTGTGGGGAGGGAGTGGCAGATAAGCAAACCTAAGAGAGTTGGCAGAGCTTGTGAAGATCCTGGATGCTGAGGAATTTGGGGAGTG


GGACCACCAACGGCTCCGTGCTGCTCTTTTATTTGGAATAAGAAACTATAGGCTGATAACTGATCATGTGGATTTCGCTCGTTAGAA


AGGTAGTTAAGCCTAAGCATAGACATTCCTCTGTGCACTTGAGGATCCTGCAGTGTCCAGGACATCTACTGATACCGGCTCTGTGCT


GCTCAAGGCCCTTAGGTAAAAGGGTATGAACCGCATGCACCCACTCATCTCCTCATGCATGCTCTGAACCAGCTATAGATTACATAG


CTGCATGATTGGTTTTAATTTCAAAGTAATTAAGATGTAAGGTTAGCTCCGGCCGCTTTCCTCCTTCTCCCTGTGCGTTTCCTCCCC


CGCTTTCCCATTCTGTGTATGACTTTGCTCTATCGCCCACATCCCTCAGGATATCTTTCTTCCCCTCATAATTGTCTTTTCAATTTC


CTGACTTGTGAACACAGATACAGAAACACGTACGTATATATTGAATTTTGAGGCTATGTTCAGCATAGAAAAGCAAACATGCAGCAT


TTGTCTTCTAAGCCCTCTGTACTTGGTTTTGCATAGTGATCTCTGGGCATCCTTTCATGGTAATCTTACCTATCGTTCAGTACCACA


CCATCCTCCTGAGCTGTCTCACCAGCTTAAATACCTAGTTCATTGTAAATGCCACAGGAATCAATATCATCTTTTCTTGTTTGGGGA


ATGATAAGAAATAAATGCCCCATGTGTTTAGTGCTGACATATGCCTCCTGTCCTTATCCCTCATACACACACACACACACACACACA


CACACACACACACACACACACAGTGTGTGTGTGTGTATATATATATATATATATATATATTCAGTGGCTTGATGTAGCTACAGATTA


GATTTTGTGCCTACATGGGGCTGCTCGTATTTCCTCTCACAATATTCTAGAATATTCGATGGCTTGTAACTTGTTTCAGTGTTTTCC


CAGAGCAAATGAGCGGTGCTCAATAGTAGAACACATGTCTCATTTGTATTTAATTATAATTAGTTTAATCTAAAATTATATTTTACA


GGTCTGCCAAATTTATTCTGTTATTATAAAAACTGAATTTTAAGCAGCCAAGGAATTAATGAATCTAGGGCTTTAATTCTAGCATTT


CCTTAAACCAGCCATGGATGATTGGAGTGAGCTGTTCAATTTAGATGTCATATGTGTGAGAACTGTCCATTGTTCCTACCTATGTGG


CTATGACTGTATCCTTGCTACCGTCACATCACATAGACATAAAAGCTGAAAGAAGCTTTGAAGTTTTGAGTCCATCTGCCTTGTGAG


ATGTCTGACCATGCCACCTCTTAGCCAAGGGCCTTTAGGCAATTTGCTCAACTTTGAATCTAACTTCCTTATCTGTGACACCGCAGT


GACAATTCCCTATGACTCCTTATTACATGTTTATTATTTAGTAATCACTAGGCATTTTTTCAAATAAGGACACTGGGGTGTGGAGCA


ACGAAATTCTTCACTTATGGTTGAAACAGGGCCGGCTGGGCTTCCTGGCTCTGTGGCACTGTCTGCTCTGCTCTGTGGTGGCACTTT


AAGGGCTTTTCAACCAGGGGGTCTGAAGCTGACACATGCTGGTTTTGTCTCCCAGGGTTTTTGTGAGGCTAAAGTGAATATCACGTA


CTTCTTATTAAGGGCATTTAAAAGTATTAAAGTTTTAATTATTTTTCTATGCTATTGACATTAGTGATACATATTCAATGTAGAGAA


CTTTAAACAAATGAAAGAATGAACTAAGGCGGGGCCCTCCATAATCCCTAAGGATAATAATAAACTGGCTTGGAATTTTAGTGAAAT


GAATACATGCTTTGGTTCCCTGTTTGTTCTTTTTAAATTTTATTTATTTTGACTTTGGCAGCTGCATCGCCTTACAGGCCAAGTGTG


AATTTTATTTACATACTGGAATCAGTCATGACACATGCCAGGATGAAAGTTAAAATCTCTGTGAAATGTAAAGCCTTAAAGGGGCGG


GGAGCTAGGGAATAGTGTGAGTTCTGGGGCATTCAAAAGCACAGGCTGTAATAATACTCAGAAGACCAAGGGGCAGCTGGCGAGGTC


TCAAAGGCTGTAGAAGTTCTTGGCTTTTCTGCACTTGTGGAATCTCACGTATTTTCGGCTTTGAGTCAGAACCATGAATTTGAGTCA


GAACCTTGAAAATGATCTGACCTAGCTTTGCTGGCATCTACCACAACCTATGGGAACAACTAAAAATCATAAAGCAAAACGCAGAGC


AAAGATGACCCAAAGAGATCTGCTCTGCCTTTGTTCCAAGGCTCTGAAGTGAGTTGATCACAGATACTGCAGAGCTCGTTTGGAGAT


GCTGACTGGTGCGTTGCTATAGATGGGGAGCGAGAAGCTTCTGGAAGCTCAGGCATTCCACACTGTCTACCCAATAGCTGGGGCCAA


TAGACAGGGGAGAGTTGGCCTCTAAGGACTCTATTACATTAGGTTTGTGACTAGAGGTCTTCCAAAGATTCTGACTGTTGGGAAGAT


GTGACTTAGCAGGCTGGTAACTAACACGCTTTATCTCTGGTTCACTCACAGGAGTCCAAGTGAAGAGAGCAAGATGGTGTCTGCCCA


GCTTCACTTCCTGTGTCTTCTCACACTTTATTTGGTAAGCACAGAGGGTCTCTGCAGGATATTTCCTGACAGCCTTCCACTCCATAC


CATGAAAAGAACATTTATTACCACTTTTTTAAAAGGTGGTTTATCAGAATTGTACAAAAAGATGTGACGTGTTCTCGTATGATGTAT


CCAGTGAAGCGACCACAAGCCCCACGGTTGCCATCGGCTGAAGGGTGCACTTTATCCTCAGCCCTTAGAAGCTAATACGCCGTGGAA


TGGCAAACTGAGCTCTATGGTTATAGCTTTACTTGTTTCTGTCTCTACCGCTGTTACCTACACCCCAGACCTTGTACATAGACAATC


ACTCTGCCACAGAGTTACAGCCAGTACTGAACAAACCCACCTTTCACCTGTAGCTTCTGGCCATAGAAAAGAATTACAATGATTTAT


CTGTAAGCCTCTATAACCCAGCTTTAAACCCACAAAAGCACCAAGAAACTATTTTTTCCCTGTTTTCACCTTTCTATGCTCTGTATT


TTTATTTTCATAAATGGCTTGGAGGTTCCTAGTTAAATTTGTCATTAGCCACATCTTCTATTGTTGCTATTGTCTGACAGGCTTTCA


GCACGGAACAGAATGGAAACTGGGCCCCAGCTATTGGGTAGACAGTGGGGTACCATCTCTACTTTACTCACAAGGCTCCTGTGGTAC


AGAAGGATGTCCAAAGTTTCAATGTCTTATGGACCAAGATCTCAGGTGTGCTTCTGCTTGTTTCCATAAAAGGAAGTTTTAGATGGC


TGTACCTAAAATCTTGCTTCCTTTTTTCTTGTACCCTAAAACTACACACCAAATTTTAAGTCCTCAAAGTCCTCCAAGGGCCTTATA


GTTTAAAAAGGTTTAATGTTTTTTATTAAAATACATTTTATATGTAATGCATATGTACACCTTAACACATTACAAAACGTACTTTTA


TCACCCTACCCTCTGTATCATAGAACTGAACCAAGATCTCTGGAGCTTCCATCAAGGCTAAGGAGGAGACTGCTGTTCAGATCGTAG


GAGAATTCTCACAGCCTGGGTCTGAATGAGGACAGTGCTCTCCCTGTCTTTCCTGCCTACGTTATCATAGGAGGACAGTAACGTCAG


TGCCAGGTTCTAGTTTGTGGCTACAACTTGCTCATGATAGGAAATGGACTGAGTAGCTTTAAGCTTTAAATCTCAGTTTTCTGTCCT


TTGGGCTGGGTCTCATCCTAGCATTTGACATAGAGGAACGTTTGCATCAAGGAGTAGCACAGCCTAAGCTCTGAATACATAAAAGCC


ATTAGTAGTCTATATTTCAAATGTCCAGCCCCTATATCCATATAGACCTGCCCTCGATAATGAATGAGGTCACCTTAACAGGCTTTT


CTCAGCACCTAGCATAGAGATAGGAGGTGATCACATGATCTCAATTAGGAAGCAGCGTTGAGATCAGAGAGAATGAACATTTAGCTG


TGGTACTTCGCTGGTGGTGGGCTCATTTTCTTCTTGTCTGAGGTGACTTGCCTTCCTTTCTGTAGATGGAAGCTGTCTTTCTGCCAC


CAACACCCTTCTCAGCTCTGGCCGTGGTGGTTTGGTGACTCATATTGTTCACATTCAATTTGAAATCTTTATAGCCCCAATAGTCAT


GTTAATGGGAGGGAAGAAAGATTTGTTGCTCGATACCAGGAGGAGGAGGATGTAACTTTGAACCCTGGAACTGACTCTCCCTCCCTG


CATCTCGACAGCTTGTCTGTATGCATAAAATGTAGCCTTGTCTGTGAGGTCTGTGGGCTAAGGAAGTTTCCATTGGTGTGGATAATT


GCGAGGCTGATTGCTCACTGGGTGGTCTCAGAGCCGAGCCTTGGAGCTCAGCTCTCTGGTAGCACTGCAGAAAACACTGTCCTTGTC


TTAGATCCAGCTACACTGGAGGCCTGTGCTCAGCTCTCCTGCCTCACCTTCTAGAAGTAATGGAGCTGGAGTAGACCTGAGAAGAAG


GAAGGAAAGGCTCTTGAAGGAAGGCAAACTCAGAGAGACGGTGCCTAGAAGTCTGGAAAATTATTGTGGAAGTTAAAAATGCTTTTA


GCTGCAAATAACAGGAAATCGGGATTTGGAGCAACTTAAATAAATGAAGGGTTATTTCTCAGCGATAACAGGAAGCCCGAATGATAA


ACTTAGGGCAGGGCTAACCATTCTGTGATATATCTGAGGGGGGATGCTTTTGTCTTTGGACTCCTCACTGCTCTGGGTGACTGCTCC


AGCTGCACATACAAAGCCCGTGGCCTTTCTAAGAACAACAGGGAGGGGTAGAAATGCCAGCCATAGCTGCTCTTTCCCTTTAGGAAG


GAAAGGCCAGCATTCAGATTATGACATTGACTTCTGGTTCTGGGTTTAGACGCCTATTCACCTGTTCTACTCCCTTTGGGAGTGGTA


GTAAGAGTCAGTAGAGATGGCAGCCATTGGCTATGGAGTATTCCCCAGGGGTTGGAATGGTGGGAGCCACACCTTCCGGCACCTCCC


TATTACAGCCAACTTTCCTTCATCACTTTTGCATCCCCTGGTGGACAATAACGCCTGGGGTTGAGGAGGTTGGTTCCAGACATGCAG


GTTCAAATCCCGCTTCTAGTTACTCTGAGGGGGAAATAACTTTGCTATGCCTTAGTCTCAATGGGGCTAGCTGTACTATACTTTCCA


TAGTATGTCGCAGAGTTATTGCTAGGATTCAGTATGCTTAGGAAAGATTCCCATGAATACCACCTTAGCAATTATAAACTTTCCTTA


CCACCCTGGTCTGGATTCGAGTAACTGCTGAGATGCTTAGATTTCTAAGGTCTTTAGGCTTTAGAACCACGTGAGACCACTGCTTGA


AGTAAACACTTTATGATTTTAATTTATAAAGTGTTGGTCAGTTGTGACGTATATATGCTGAACTTCTAGTTTGACCGGAATTTACCA


CGTGATTGTGTGCCAAGTAAGCATTGTGCTAAACTATCTACATATTCTTTCTCCCTCTGATAAATTCAACCGCCTTTGAGGTGACTA


TAGACTCCAGGATGCTGGGGACGTCTCACAAATGTCACAGAACATTTTAAGTGGTGGGGGTATTTCAAAAAAGCTGGTATAACCATG


TATAATTTATAAGGCAGAACGGCTCTGAGAGGCTGCAGGATTTTGTTTAGTTAAGACAGAGCATGTGCTGTCCCTGCTTGTCACACC


CATGGTTTACTCCGGGTTTCACCCTCAGAAGTCTCCTTTGTAACATGGGAGTTAAGATTCTTCCTATGGGATGGTAGCACTCATGGC


TAAATGAGAAAAAGCAATTTGAAACTCATGGCAGACTACTTTGGCAAAGTAGGAGAGTCTCTCAATAAACACTAGGCCAGTTTGCTT


TCTGACCAGGTCCACACTATTTTTGGCCATCATGGAACCCTCCACTCCGTACATTGTTTCTGCAAGTGACACCCATCCATTCACACA


CGCTCTCTTTATTAACAGACCTGTGGATATGGCGAAGAAGGGAAGTTCAGCGGTCCCCTGAAGCCCATGACATTCTCCATTTTTGAA


GGCCAAGAACCGAGTCAAGTCATATTCCAGGTAAAGACTGATCTTTGTTATCTTGATTTCTGTTCGTAGTGGACCTTTGCTCTCATC


TCTACTGAGCAGCAGGGAGTAACACGAAGGCGGGCAGTTTTTATCCTCTGTGACTTTGATGAAGCTGAGTTGCAGAGCAGTGTGGGT


GTAGCATAGGAGGAGGAGCTAGCATTCTCACACAGGCTCCCTTAATCACGATTGTGGCCAGTGCTTCAGTCCTCTCAGAGGAGGTCG


GCATTATGGACTCCACCTCTGTCCTGAGTGCAAAAGCTGCTGATTTCTTCGGGAGGTGCTGGCTTTCTGGTCATTAGGGCATCCGCT


CCTCACCTCGCTTGGCCTGTGAGGTGTTTGAAGTGGGTGGAGGAGCTTCTCTGTGAGACCACAGCCTGACTTCCTGCCTGCCTCCTC


TGAATCCTTGTCGATGTTCTTGCCTATGGGTTGCCCAAGTCATGTTGGACATGTTAATCACCATTTCCATTACTGTGATGATTTTAG


TTTTATTTTCGGTCGCTGTGATAAATACCCTGACAACAATCAACTTACGGGAGGAAGGGTTTCCTCTGGCTCACGGTACCGGAGGAT


ACAGTCGGGCATGGTATCGAAGGCAGGGCAGGAGGAGTGAGACACTGCTCAAATTCCGTACATGCTCTGTAAGCAGAGAGAAAACAG


GAAGTAAGGGTCAGGCTCTAAAACCTCAAATCCTCTTTCTAGTCACCCTGTGATGTGCGTCCTCCAGTGAGCTCCACCTCCGAAAAA


ATTCCAAAACTGGGCCACCAGCTGGGGCCCAAACATTCAAATACAGGAATCTGTGGGTGGCATTTCACTTTCAAACAACAATAATTG


CAGACTACTGGGTGTGGAAGGAGAACGACTCAGAGAGAAAAAAGTTTGACTCATGACTTCCATCCATGGTAACTAGGCTCCATTTTC


TGAACCTTTGCTGAGGCAGGGCACGGTGGAGGAAAGCCAAGGCCTGTGGTAGTAAGAAGCAGAGAGAGCAGGAAAGGTCCAGAGATA


AGCTATGTATTCTAGAGGTACTCTCCTCTAGAGTGACCCATTCCTCTAACAGCAGTTCTCAATCTGTGGGTTGGGTCCCCTTTGGGG


GTCCAACGATCCTTTCACAAGGTTCACCTAAGACCATGGGCAAATACAGATATTTACATTATGATTCATAACAGCAGGAAATTGCAT


TTATGAAACAGAAACAAAAATATTTTATGGTTGGGAGGTCACCACAATATGAGGAGCTATATTAAAGGGTCGAAGCGTTAAGAAGAT


TGGGAACAACTGCTCTAAGTAGCCCCCACTTCCTATGATCCCATTCAGCAAATGAAGTCATTAAAGCATTTGTCTCCTGATGATGTT


CACACTCTTACAATCCAATTCCCTTAACGGCATCACCAGATGGGGACAGGACCTCCGATACATGAACCTTATTGGAGGCAGACAACT


CATATCCCAGCCATAATCTTGGCAGGTAGTTAGGTACCCATGAAAAGCAATAGGGGCTGGGGAGATGGCTCAGTTGATAAAGTGCTT


GCCACACCAAGCGTGAGGACGTGAGTTTGGATCCTCTGCGCCCACATATATGAAACACTAGATAAAGTGGCTTGTACCTATAATGCC


ATCACTGGAGATACTGAAGCAGGAGGACCCCAAGGGCTTGCTGGCCCAGCTCTTCTTGCCCAGTCAATGAATTCTACATTCAGTGTT


ATATTTCTGCCTTGTAACAGAATGGGGAAGACCTATGAGGGTAGCTCAGTGGGTAAGGAAACTTGTTCTGCAAGAAACAAAAGACTG


AATTAGAATCCTAAGCACCCACGTAAAAGTTGGGTATTGGTGCTTGTAACCTTATCACTGAGGGAAGAGGTAGTCAGATCCTGAGAT


TGCACTGATTGGCCAGCCTACTCCAAATAGCAGGCTCTGTATCAGTGAGAGTCTCTGTCCCATGGCAAATAGGCAGAGAGTAATAAT


GGGCAAAGACACCCAATGCTCTGTTGTGACTTCCTCGTGTGTGTGCAGGGAAATTCAAGCTGTGTACTCACACTCGTGTACCCATAC


CACATACAACATGCATCACATGAAATAAATGTGGAGATTAATACAGACTTCTGATGTTAAACTCTTACCACATACACACTCACACAC


TTGAGAACGTGTACACACGCATACACAGAACACATAAATATGTGTATGCCATACTTTTGAAGGTGGAGTGAAGAACCTTGGCTCTCC


CCCAGGGGGCCACTGACATGCATCAGAAGGAGATGACATTCCCTACAAATGTACCCGAGGGTCCAGGCAGAGCATCCTCTCTACATG


TGTGCATCTGCCTTCTCTTCCCACCGCAGGCATCTTTATAACATGGGACAAACGGCAGTGACCTTGCGTGGGAATAGTTTGTCTCTT


AGCTGCTCTCAAGGACACAGTGCTTTTTCTCCTGTGCTGTTTTGCTCCAACAACATGCCTTAGAGGACACTTGAAATATCCAAGCTG


AAACCTGGGACAGGAGACCTCCTTGCTCCCAGAGCCCATGTTTGACAAGCTTATACATCACAGGACAAGTCACCATTGTACAGTACA


AATGGGCTTGACTTAAGTTTCTGGTCAGAAAGATCTGTCCTTTGACTGAAAGACAGACAGCTAGGGAGATTGCAGGGTCCTGGCTAG


GGGGCTGCAGTACAAGTCTTTCTCCTTTTCTGCCCTGCCAGGGAGCTCATGTCAAAGAGTCTCCCTGATATTTTTTAAAAATCTATT


TCCTTAGAACATTATACTTTAAAATCTGATATGAAGTTCACACACTAGGCATCACATCTATTTATTTAATTTATTTATTTAGCATAA


ACAGAATGCCTACTGTGAGGTACAACCAATTTAAACTTATCCACGACTGGCTTACAAGTAAATGAGACTCAGATTATGGTTATTTTA


TTTGGCTTTGACAATTACTGGGGGGTCACCCCTAATCGACTCTTCTAACTGCTGCCCTGGCTACCTCCCCAGCCGTGTACCCCAGAT


ACTTGCTGTTTCTCCTGGCCATGTGCTTTCCATTCATCTCCCCTCATGGGTGCTTCTACTCTTTTCTTCCTCCTTCTCCACTGGTCT


CTCCTCCAACCAGGTCACAGATACCCCAAGAACCTCTAATCCCTTCAGTAACGGAGCTGGTGACCATCAGAAGTCTGTCTGCTGCTC


AGCTCAGAATAGAGCAGATCACCGCTTACTCTGTGCTCCCCAGTAGCTCCACTGGCTTTCAGTAAGACATGGACTCCCTTCCCCTCA


CCTCCACACCATACCATTTCTGTCTCTCATTAGAAAAACAAACAGGCTTCTAGGGAATAATAATAAATAAGATAAAAAGAAAACTAA


CACACCAGAATTGGACAAAATAACCACAAGGAAAAGAGCCCAAGAGAGACATAAGAAACAGAGACCCACTCATGGGCACGTTCAGGA


AGCCCATGGGAACACTAGGCTGGAAAACTGGAAGCCATCATATATGTGCAAAGGATCTGTGGGGTAGAAAGAAGAAAAATTATAAAA


AATACAATAAATCTTCTTTGAAGGTCTGATAGAACTCTGCAGTAAACCCGTCTGGTCCTGGGCTTTTTTTGCTTGGGAGACTATTAT


TGGCTGCTTCTATTTCTTTAGGGGATATAGGACTGTTTAGATCATTAACCTGATCTTGATTTAACTTTGGTACCTGGTACCTGTCTA


GAAACTTGTCCATTTCATCCAGGTTCTCCAGTTTTGTTGAGTATAGCCTTTTGTAGAAGGATCTGATGGTGTTTTGGATTTCTTCAG


GATCTGTTGTTATGTCTCCCTTTTCATTTCTGATTTTGTTAATTAGGATGCTGTCCCTGTGCCCTCTAGTGAGTCTGGCTAAGGGAG


TATTCTGTTGGTATAGCTTCAAGTTTGTCTGTGGTGTTATTCCAAGCTTTCTTTCCTTATTGGTTCTTGATTTGCTCTATAATTATT


GGAAGTGATGTCTTGAAATTGTCAGTAATGACAGTTTCATGATCATATTTCTGTCCACTCTCCCACTCTTTGATGCACTTTAGAGGC


TGTCTCTAACATTTAGGTGTGCAGATGTTTGCAGTAGCTATAGTTTCCTGGCATGCTAACCCTGCTATATCTTGTCTTTCCTTTTGA


ATGGGATCTCATTCTGTAGCTCAAGCTATTAACTCATTCTACAGCCCAGGCTAGCAAGAATTTTTCCCCTTAGTTTCCCAAGAGCAG


AGATTACAGGGAGGAGCCACCGGCCTAACTCTTACTTTTTATCTATAACAAGTTTGCCTGAAGCTCTGTTTTGTCTGGTTCTAGTTT


AACTTCACCCTCACTTTGGGCAACTGTTTTATTGGATTAGAAGTCTTCCTCATCTCACCAACTGTAGCACTTGGGATGTGTTATTTC


GTAGCCCTTGGCCTTACTGAGAAACCTCTTCATTTTATTGAAAAGCTCTGTGTGTCCTGATTCACTAGAGTCCTTCCTGCTATTTTT


CAGGAAGCTCCGTCTTTCAGATGTTTGATTGTGCTGCATTTGGGATCATGTGTCTGTGCCTTCTGCAGTTCACTGAGCTTCATGGAT


GGGTCTGCGAGTGTCTTCTTCACATTTGGGGAGTTTTAGGCATTCTGTCTTCAAATCATCTTTTCTCTTCATTCTTCCTCCCCTATG


GGAATTTTACAGTACAGGTATGCATTTGCTTGATGGTGCCTTTTCAGGCCTTCATTTTTGTTGTCGGTAGTTCATTTTTCTTTTTTT


TTCCATTTTATTAGGTATTTAGCTCTTTTACATTTCCAATGCTATGCCAAAAGTCCCCCATACCCACCCACCCCCACTCCCCTACCC


ACCCACTTCCCCTTTTTGGCCCTGGCGTTCCCCTGTACTGGGGCATATAAAGTTTGCAAGTCCAATGGGCCTCTCTTTCCAGTGATG


GCCGACTAGGCCATCTTTTGATACATATGCAGCTAGAGTCAAGAGCTCCGGGGTACTGGTTAGTTCATAATGTTGTTCCACCTATAG


GGTTGCAGATCCCTTCAGCTCCTTGGGTACTTTCTCTAGCTCCTCCATTGGGAGCCCGGTAGTTCATTTTTCAAGTTCTCTGGTTTT


CCACCAGCTCAAATATTTTTTCAAGTTCTCTCAAATGTTTATTTTAACTAATATTCTTTCAACTCCAGAAATCCTACTTAAAAAAAA


AAAAACAACAAAATTTTTATGTCTGTATTCTCTATTTGGCATGACTTATTTTTATGCTTTCCCTAGTCTTCTAGAGAAGGCTTCCTT


TAATCCTGGATCTATTTAAAATAGATCATTTAGGATCTTTAGCAAGTTCAACATCAGGGCTTTCTTAGGAACAGTTTTTGTATCTAC


AATGTACGTTAGTTACTTATTTAGCTGTATGTCACACAGACATTTATTGAAGAGTGGACATTTTAAATGATGTGATATGGTAATCTA


GGCATCCTGTTGCTTCCTTCCTTAGAGCATATTGCTTCTACTTCTTGCCTAGTGGCTTTTATGGACTAAGTCTGAAAAGTCAGTATT


CATTGTTATGTTCAGCCACTGAAGTGCCTGATCACCTTGGTGCTCAGTTAATGATGGGACAGAGATTATGTTAGGTGCATTGGATCA


GAAAGTCTCAGCCTTCACCAACATTGGAGCATGTTGGAGCACATTGGAGCATGCCACTAGCAGTGTGGTGGAGAGTTTACAGATTTG


GCTTTCCCTTCATTTCATACGTGTGTTGAGCCTCAACATCAGCTGGGGTGAGGGGTTAGAGCCTTCTCTGACCCTTCCTGCACATGC


TGGCAGCTCGGTTAAATGGATGATGCTCCAAGGACTAACACACCAGGTTTGCCGAGTCCCCTGTGGGCAGCTTATTCCCCCAGCCTT


TCCTTTAAATGTGTGACCAGTTTCTCATTTGCTTCAGCTATCATTCCTGCCTTAAGCTCATCAGTATCCATTGCTGACAGGTCTGAA


GATTACTTATTTTAAAAACATTTTTATTTATTCTTGGAAAATGTTACATGTATCATGTATGCAATGTATCTTAATCATATCCAGCTC


CCACTCCCCATTCCAGTTTCCCCATCCCAGACCCTTCCCAATGCATCTCCCAAACAATTTCATGTCTTCTTTTTAAATGTTTATTTT


TAACCCCTGACTCCAAGTAGAGCTGCATATATGTGTGCATAGTATAAGGTCATCCATTGGGCATGGTGTTCCAGTGGCCACACCTCT


CCTAAGTACAGTGACTCTCCCTCCCTGCAGCAACCATCAACTGCAATACTTCCAAAGTGAGGGCTGGGCCATCGTAGCCCTGCCCCT


ACCCATGGTGGAATTTTAACTTAGTTCATGCGTACAACATCCATGTCTTGTTCAAAAGACAGCATGCACGCGCGCGCGCGCGCGCAC


ACACACACACACACACACACACACACACACCACACACACACACACACACACACACACACACACACACACACACACACACACACACAC


ACACATTTAGTCTTTCTTCAGTGATGTACCCTGTTCCCTAAGCCTTTGGGAGATATTTTATTCACAACAGGGACTTGCTATATAGAA


CTTGGGTTGGCCCGGTGCTATATCCTAAGCTGACCTCAAACTTACAGCAATCCTCCTGCCTCAAACTCCCAGGTGCTGAGATCTATG


TGTGAGTACTATGCCCACCAGTTTTGCATGGGTCTTTTCAGTAGAAGTCCGTGGAACATTAATAGTGATAAGAACTGACTCAGATTA


AATAGACACCAGCAGGTTACACAATGACGGTTCTCTGGCAATGGCTCTGGGAGTTACTGTCTTCTCTGCCCACTGCCACACTGTGCT


GGTGAGTCTGTCCTGTCCCTTCTATCCTCTTTCACACTGAGCTGGAAGGTCAGTGGGGTAAGGCAAATTAAAACAGCACAGGTTGGT


GCTTATTGACATCCAGGAGGGTTTTGGTCAGTTCTGATGCTCTGACAAAGTTGATAAATTGGTGTTTGCCACTATCTACCAACATTT


TCATGCTTTACTGGAGGAATAGCAGGGTCTCACTCCATCTCTCCCATTGACGTCATACTCGTCTTAAAACACTAACAGTGGCACTGT


TTATTAATAGCCGTAATATCGACAAGAGGATTTGTAAAGCCCTGTCTAGCCATGCTGTTCTCACCTTGTTTGTACACACTGCTGACA


TGCGCACTTCTGCTTCAGAGGCAACCATGGCCTGGCTTTACTTGTGTGTACTTTTGTTACTTTATTGTATTGTGTCTTTTGCCCTTT


ATAATGAAGCTTAAAGGATCAATATTGATCATGTTCTCTGCTTTAAGAATTCATGAATTCATAGATATCTGAGTTTTTAACTTTGCT


AACATAACAAACATTTCCTCTTGCACTCTAAGAATGTAATTCATGCTTAAAAATTCCAAATTTTTATATTATTGTTTACTATTAAAG


ATGGTACTTTATACCTCAAGCCATTTCCAGATGGGTCATATAAATTATATCCTATCAACAAAATATCTATTTCTTTGCAGCCTAATA


TCAATGAAATGTACTTAAAATTATTAGTGAAGTTTAACACCTTTTATATATTCTTAGTTTCATGCAGAATTCCTAATTTTTCACTGT


TGTCTTATAAGGAGCTGCATCTACCTCGTGAAGAGTTGTTGATTAGTTTTTCTATGTTGTAGAAAGTCACCATGAAGATTATCATTC


AGGAATATGTGATGTTGAAGGCACTTGTAGACTATTTTCTTTAACATTAACTTGTGTCTTCATCTTTGTCACAAGTATTAAAGTACT


GAGTGACATCTTTTGGTTTTGGCAATAAAGCTAGAAATCTTAATGTTTCTTAGATGCTGGTAACATCATGGCTCTCACATATTCACT


GAAAACTATCTTTTTTAATATAATTTTTTCTTAGGTATTTTCTTATTTTACATTTCAAATGCTATCCCCAAAGTCCCCCATACCCCC


CATTCCCCTACCCACCCATCCCACTTTTTGGCCCTGGTGTTCCCCTGAACTGAGGCATATAAAGTTTGCAAGACCAAGGGGCCTCTC


TTCATTGGATGGCTGACTAGGCCATCTTCTGATACATATGCAGCTAGAGACACGAGCTCTGGGGGGGGGGGGGGTACTGGTTAGTTC


ATAATGTTGTTCTACCTATAGGGTTGCAGATCCCTTTAGCTCCTTGGGTACTTTCTCTAGCTCCTCCATTGGAGGCCCTGTGATCTA


TCCAATAGATGACTGTGAGCATCCACTTCTGTGTTTGCCAGGCACCGGCATAGCCTCAAAAGAGACAGCTATATCAGGGTCCTTTCA


GCAAAATCTTGCTGGCGTATGCAATGGTGTCTGTGTTTAAAGGCTGATTATGGGATGGATCCCCGGGTGTGGCAGTCTCTAGATGGT


CCATCCTTTCATCTCAGCTCCAAACTTTGTCTCTATAACTCCTTCCAAAAACTATCTTTTAGCATTAGCTACAGTTTAAAGCACCAC


AGCCTTTTCTCGGCATATTGGATTGTATGATGCTTTGTTTATTGAGAGAAATGTGTTCTGAATGCTACATAAAGGATGCACAGACAA


GATTTTAGCATTGCCACCATAAAGGGCTCAAGGTTTCTTATTCTGCGATGTACAAATAAAAAAATGGAAATAGGCATCTTTCTACAG


ATCTACAGCATTGTGCTTTCCTCAGAACCTGATGTGATGGTAATTCTTTTTTCTTTTTCTCAGTTTAAGACCAACCCTCCAGCTGTG


ACTTTCGAGCTAACGGGAGAGACAGATGGTATATTTAAGATAGAAAAGGATGGACTTCTGTATCACACAAGAGCCCTGGACAGAGAA


ACAAGAGCGGTTCATCATCTGCAGGTGAGCTGAGACAGTGGGATGACACACAGTGGGATGACACTCAGTGGGATGACATGCAGTGGG


ACAACACACAGTGGGATGACACACAGGCTTCTGTAGCACGCTCAGTTCCCGAATCCCCTGGGACCATTATCCCTTGCTTCTTGTTCA


GTTCTCCTGGCATTAGTACAAAACTGCAGTCCTCATATGACCTCCCTCCCTCCCTCCNNNNNNNNNNNNNNNNNNNNCCTCCCTCCC


TCCCTCCCTCCCTCCCTCCTCCTCTTTCCCCCTTTCCTTTTCCCCTCATTCTCCTCGCCTCTTTGAAACCGACTACAGAGTGATTTT


TGACCATAGTAATCCAATTTACATGATCAAAGTCCTCAGATGGCCATACTCATTTGGGTACTGGGGCTGAAGCCCAGCACTGTGCTC


CTGGTGTGCCCTGGTGCTTGGTATGTGTGCCTCACACCCACTATGAAGGCAGCATCAGTGCTGCGCAGAGCCACTGCGGCCCCAGAA


TGCAGAAGGAACTCATGGTCCTACTGGAAATGCTCTTCCTTTCCGTTTCCCCATAGCTTCCTAGTAGGTTTCTGAATAGCTAGAAAG


GCAGAGCGCTAACTGAAAAAGAGCAAGCTGAAACCATCTTCACTTTCTGCCATGGGCTCTGTAGACTGACCACTGTGCCAGCTCTGA


GGAGTCATAGTACACCATCACCTGAGTAATGTTCTGCATCCAGTACCCTGAACATCTAGAAAGCTACTGCCATCATCAGGGTAGCTT


AACTGATTGGACCCTTATTTTAGCAGTATATAATTTGGGCTTTTGTGGGTTCTTCATCTCCTGCAGTCATCAGGTCATTGGTCTTTT


GAATTTTTAAGTTCCTATAAGTGACTTTGGGGCATGTATCTTAGTCCAGAGTCACAAGGTAGCTTTCTTTTCTTCAACAACAGCTTG


CAGCCTTGGATTCTCATGGAGCTATAGTGGACGGTCCAGTCCCCATCACCATAGAAGTCAAGGACATCAATGACAACCGACCCACGT


TTCTCCAGTCAAAATATGAAGGCTCAGTGAGGCAGAACTCTCGCCCAGGTAGAACAGTCAGTCTGAGTATGTCTGTGGGGTGATGAA


AGAGTGGAATTGTGTGGCTGACAGTTGTCACTATAGCTCCACAAGACTGACTATCTAATGTAAATTTCATAGCGATCTGAATGCTGT


TTTATTGTGCCAATTGTTTTGGACCAAAGTCTCTCATCCTTGGCCCTGTTTAGTCTTGGGTAATGTAGGATGTTTGGAAATATCTCA


GACCTCTATCTATGAGATGCCAGGGACACTCCTGTCTCTAAACTGTGACAATAAAAAATGTCTCTAGGAGATCTAGAGAGAAGGCCT


AGCAAGAGCCTTTCTGCTCTTCAGAGGATCTGAGTTCAGTTCTGAGCACTCTTGCTGAGTATCTCATAAATTGCCTTTGACTTTGGC


TTTAAGGAATTCATTGGTTTTGTTTTTGTTTTTTTTTTTTTTTTGTTGTTGTTGTTTTGCCTCTGTGGACACCCACATTTGTGTGCC


CATACTCCTCCCCTCAATTAAAAATGGAGTAAATCATTGAAAGAGTCTCTAGATCTTGAGAAATGTACAGTGTAAGTCAAAACTATG


GTTCTCTAGTGAACTTTCACTAAATACCACACAGCTTGAGGACATCGAAGGACTGTCTGGAAAAATGAGCTTCCTCTCCAATATCCT


TGTGGGATACTTAGAGTTACTGTTGGCTCCTTTCCTTATTGCTGTTCCCCAGCTGTGGCCTGTGCCTTCTCTATGTTGACCTACTCT


CTATTTCTAGATCCTTGATCTTTTCATCAACTTATAACAAGGAATCATTTGTGTTATTCAACCCCTTTCTTTTCTCAGTCTCCAGTA


GGCAAGTAACCATTCAGGGATGGCTGCACTGTCCCTGTCCCTTGTCCCTAGTGGCATCCTTGTCAGTGTTTAGTATCTGCTTCTCCT


GGGTGAGTGGGAAGAAGTGTGGTTTGTTCCCTCTGCAAGCTTTCATGGTATAACTATTTACCATGGCCTATTTCAAATTACTAGTGA


TATTAATACATGACTTTATAGACTTTGGGTCTGGTTGGTTTTAGCATATGGTGTTTTTATTTGTATGCTTTTCTTGTAATCAAATTT


ATACAAACTTTAGAAAAATAACTGACTGAAAAATTTCTGGAAATTCAAAATTGTGCTCTCCCAAGGTGAGTCCAGTGTAGCACTGGC


TAACATCGTAGAAAGTAAAACACTGACTTAGTGAATAATTTAAAAGAGCACAGAGTGTTTAGTGAAAAGTATATTTTTCAAGACAAA


AATAGTTTAATGAGAAAAATGACATCATTTGAATCTTTGCAAGTTTCTTAAATGTCTGGATGAATAAAAACAATTGGGATAAAGGTC


TGTGTCTGGATCCATGATGTTCCCACATGCTGTTTTTGTTGAAGTAGTATGTGACGAAAATTAGTCTCACACAGATCTGTAGCTTAG


GAAATGAGGAATATTTTAACAGCATCTTCAGATATTATGGACATTCTTTCATATACAACCAAAGCTTGAAAAATGCATTTTTCTTGC


AGATGGTAGCAATATAATAATGGTATATTTTGTACTATTTTACTTTAAAATCCACTAAATTATCTTGTTCTTAAATGGACCTTTTCT


AGATGTGATTTCAAACACCATAACTTTTTGAAATATTCCTGAGGACTCCTATAGGATACAAAATAAAGATTAATTTTTCCAGTTAGG


AACTGAGGCAATTTCCTCCACTCTCTTTGCATCTCCTGAGGCAGACATGGATACAGTTGCTTTAAGTTTCAACTCTCTTCTGCGTAT


GCTTTGTCACCAGGAAAGCCTTTCATGTATGTCAATGCTACAGATCTGGATGATCCGGCTACTCCCAATGGCCAGCTTTTTTATCAA


ATTGTCATCCAACTTCCCCAAATCAACGATGTTATGTACTTTCAAATCGACAGCAACAGGGGCAATAAATCGCTTACCCCAGAAGGT


AAGTCAAGGCAAGCCCTCACAAACCTCAGCCAGAGGAAGGTCTGTCACCTGTGGGCACATGTCTTTTCTCCTTCTCCTCCCCAACTT


CTACAGGATCCCAGGAATTGGATCCAGTGAAGAATCCTTCCTACAACCTGGTGGTCTCGGTGAAGGACATGGGGGCCCAGAGTGAGA


ATTCCTTCAGTGATACTACATATGTAGATATTTCTATTAGAGAGAATATCTGGAAAGCACCAGAACCCGTGGAGATTAGAGAAAACT


CGACTGATCCTCACCCCATCAAAATCACTCAGGTAGTGTCCAAGTGACATTTATTGCTAGTTCGGATCCATACCTTGATATGTAGAG


ACATATTTTGTGGTCTTCACTAATTGTTTTACTAGATAGAGTTTTGCATCATATAATTACAAAGCAAACTAAGTAATCTCCAAAGAT


TATCATCACAAGCAGAAACTTGGCCCATGTGCACAAACGCGCGCACACACACACACACACACACACACACACACAACACACACACTT


TATTGTGGTGTTTTATTGTTTTCATTCAGCAGTGTGAAATATAGCTGCTTTATAGTAGGTTGAATGGCATGTGGTATACCATAAATA


TATGTTGTTAGTAATAATATCAGAGAAACCAGGCCTTGTCTATGTATCAGGCCTTACTTTTGAATATTTTTTGTTGTTGTTTGGAGG


ATAACTAGGGGTCAGTAGTTATTTTTATTTCTGAGATCTTTCAGCCTTTAATATTTGAGGGAGTACCCCTCATCATGTGTCTCAACT


AAATGAATGAATGAATGAGTCTAAGTCAGTTGTTCTCAACCTTTGGGGGTTGAATGACCCTTTCATAGGGGTCACATTGGATATCCT


GCTTATCAGATATTTACATTGCGATCCATAGCAGTAACAAAATTACAGCTATTTAAGTAGCAATAAGAATTTTTTTATGGTTGGGGT


TACCAAAACATGAGGAATTGTATTAAAGGGTCTCAGCATTAGGAAGGTTTAGAACTACCTCTTTAAGGAATCCTTTATTGCTCTGGA


TTCATCTTAATTTTGGATTCTAGAAGCTCATCATACATCATATGAAGTGCCTTTTTTCTTGATAAATTGATGTTATACCCAGTCAGA


GTTCTAGAAGAAAACAACCTGTGGGCTCTTTGTGAGTTTATAGATTGCTTTAAGGAAGAAAGAATTCCCTTGTCTGCTTTTAAAAGG


TTAGTTTAGGTTGAGAATTTTAAATATGTTACTCAGTTGCCTTAAGAAACTGCTCATGTGCAGACAGAGTTGTGAGAAAATTCCAAG


TGAGAATATAGAAGCTGTTGATCACCTTTTCAGTCTGTTAATTCTTGTGTTTTTTCCCACCACTCGCTTTGGCCGTGCAGGTGCAGT


GGAATGACCCAGGGGCCCAGTATTCCTTAGTCAACAAGGAGAAGCTGTCGCCGTTCCCATTCTCGATCGACCAAGAAGGAATATTTT


ATGTGACTCAGGCCTTGGACCGGGAGGAAAAGAACTCAGTGAGTGAGACGGGATGTTCCGTGGGCCACAAGACAAATCCTATGTCTA


CTTACAATTGAGGACAAATTAATTGTAAATTATTAAAAAAAAATGGAACAAAACTGTGTTCTAGATCCTGGATGTTTGTGCATTCTC


AAAGACACAGTGATTCGATAATTTCCCCACAAGTGTAGCCAACATACTTAGAATGGAGAATTGAGGGGGGAGTAAGTATGTCTGTGG


GATGATGAAATTCACTCCCCCCCCTTCATTTCTCAATTCTAAACATGTTGACACTAAGGTGAGAGATGGTTAGCAAAACAGTTATTT


TCCTCCACCTGTTAAAGTGAAGGCATCTTCTTACCTTTGACCTTCACATTGCAGCATGTTTTCTTTGCAACTGCCAAGGATGAGAAT


GGAAAACCACTTGCATATCCACTGGAAATTTATGTGAAAGTTATTGACATTAATGACAACCCACCGACATGTCTGTCTCCAGTGACT


GTATTTGAAGTCCAGGAGAATGAACCATTGGGTAAGAAATGAGAGCTGTTTGATGTCATGAACCTGCCTTCCTCAGCTGCTCCTGTT


ATCCCTTTCTAGCCTCTGGGGGGTCAGGTAGACCTATTCTGCAGTCCATTGTCCTTGTCACAGACCTTGAAGGTATCATGAAAGTCA


TATAGGTACAACACTTTGAAATGAACACTGTCTCTGGTCCTCTTAAGTTTGATGCTTTTATAACTGCCACCACCACCACTGTTTCAA


TGACAGTCACTGCAGAGCAGCATCTTGTGTACAAGTCCAGAAGGGTCCTTGTTGCAAGATTTTCCCTTCAGATATCTTATCATGCTT


CTAAACAAAATACTTTCAAGAGATAAAACCTCATCCAGCATGCTAAAGAACTTGATCCTTTACATCCACAGCCAGATATCCCACAAT


AAGTAGACAATACCAAGTTCAATGTAACCCTGTGGTTCCCATTTGCGGAAGCCAAAGATAACAGAAACCTGGCAAGTGAAGTTTTAA


GCCTCAAGCATGCTTGTCCTTTTGATCTTTCTATGTTTGAGAAGAATGTATCTCCTGATAGCTTTACATTTGTATAGGGACGACACT


GTAAGAATGTTAATGACTTGGGGGGGGGTGTTGTCTCTCTCCTGGATTTGAAGCTTTTGTCTATTTCCATCTTGGAGGTGAGCCCAT


TGAGTAGGCTGATGTGTCTTTTGTGTTTGGGTTATGTACTTTTTAAGCTTGTGAGATCAGCATCTTTGTGGTCCCCATGGGTATGGC


CTACCCATCTAGGGATGGACATTTTCTTTGATCCTTCTGCTCTGGCTGCAACTCAGCTTTGACACAGCAACTGCTTTCCTGGTGGCT


TGGTGGGTTTTCCTCCCATGTAATCATTCTTTGCCTCCTGGTGTTAGGTGTCAGTCACACAGAGGTTGAATATTCTCTGTGTGTCCT


GCACTGGTGTTCTTCATTTTATTTATCTAAATTCCTGCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTATTGTTGTTCCACCT


ATAGGGTTGCAGATCCCTTTAGCTCCTTGGGTACTTTCTCTAGCTCCTCCATTGGGGGCCCTGTGTTCCATCCAATAGCTGACTGTG


AGCATCCACTTCTGTGTTTGCTAGGCCCCTGCATAGTCTCACAAGAGACAGCTATATCTGGGTCATTTCAGCAAAATCTTGCTAGTG


TATGCAATGGTGTCAGCGTTTGGAGGCTGATTATGGGATGGATCCCCGGGTATGGCAGTCTCTAGATGGCCCATCCTTTTGTCTCAG


CTCCAAACTTTGTCTCTGTAACTCCTTCCATGGGTGTTTTTTTCCAATTCTAAGAAGGGGCAAAGTGTCCACACTTTGATCTTCGTT


CTTCTTGAGTTTCATGTGTTTTGGAAATTGTAACTTATATCTTGAGTATTCTAAGTTTCTAGGCTAATATCCACTTACCAGTGAGTA


CATATCATTTGAGTTCTTTTATGATTGGGTTACCTCACTCAGGATAATGCCCTCCAGGTCCAACCATTTGCCTAGGAATTTCATAAA


TTCATTCTTTTTAATAGCTGAGTAGTACTCCATTGTGTAAATGTACCACATTTTTTTGTATCCATTTCTCTGTTGAGGGGCATCTGG


TTTCTTTCCAGCTTCTGGCTATTATAAATAAGGCTGCTTGAACATAGTGGAGCATGTGTCCTTCTAACCAGTTGGAACATCTTCTGG


ATATATGCCCAAGAGAGGTATTGCAGGATCCTCCAGTAGTACCATGTCCAATTTTCTGAGGAACCGCCAGACTGATTTCCAGAGTGG


TTGTACGAGCTTGCAATCCCACCAACAATGGATGAGTGTTCCTCTTTCTCCACATCCTCACCAGCATCTGCTGTCACCTGAATTTTT


GATCTTAGACATTCTGACTGGTGTGAGATGGAATCTCAGGGTTGTTTTGATTTGCATTTCCCTGATGATTAAGGATGCTGAACATTT


CTCAGGTGTTTCTCAGCCATTCAGTATTCCTCAGGTGAGAATTCTTTGTTTAGCTCTGAGCCCCATTTTTTAATGGGGTTATTTGAT


TTTCTGGAGTCTACCTTCTTTATATATATTGGATATTAGTCCTCTCTCTGATTTAGGATAGGTAAAAATCCTTTCCCAACCTGTTGG


TGCCTTTTTGTCTTATTGACAGTGTCTTTTGCCTTACAGAAGTTTTGCAGTTTCATGAGGTCCCATTTGTCAATTCTCCATCTTAAT


AGCACAAGCCATTGCTGTTCCATTCAGGAATTTTTCCCCTGTGCCAATATCTTCGAGGCTTTTCCCCACTTTCTCCTCTATAAGTTT


CAGTGTCTCTGGTTTTACGTGGAGCTCCTTGATCCACTTAGATTTGATCTTAGTACAAGGAGATAGGAATGGATAGATTCGCATTCT


TCTACATGATAACCACCAGTTGTGCCAGCACCATTTGTTGAAAATGCTGTTTTTTTTTCTACTGGATGATTTTAGCTCCCTTGTCAA


ACATCAAGTGACCATAGGTGTGAGGGTTCATTTCTGGGTCTTCAATTCTATTCCATTGGTCTACTTGTTGGTCGCTATACCAGTACC


ATGCAGTTTTAATCACAATTGCTCTGTAGTAAAGCTTTAGGTCAGGCATGGTGATTCCACCAGAGGTTCTTTTATCCTTGAGAAGAG


TTTTTGCTATCCTCGGTTTTTTGTTATTCCAGATGAATTTGCAAATTGCTCTTTCTAATTCGTTGAAGAATTGAGTTGGAATTTTAA


TGGGGATTGCATTGAATCTGTAGATTGCTTTTGGCAAGATAGCCATTTTTACAATGTTGGTCCTGCCAATCCATGAGCATGGGAGAT


CTTTCCATCTTCTGAGATCTTCTTTAATTTCTTTCTTCAGGGACTTGAAGTTTTTATCATACAGATCTTTCACTTCCTTAGTTAGAG


TCATGCCAAGATATTTTATATTATTTGTGACTATTGAGAAGGGTGTTGTTTCCCTAGTTTCTTTCTCAGCCTGTTTATTCTTTGTGT


AGAGAAAGGCCATTGACTTGTTTGAGTTAATTTTATATCCTGCTACTTCACCGAAGCTGTTTATCAGGTTTAGGAGTTCTCTGGTGG


AATTTTTAGGGTCACATATATACTATCATATCATCTGCAAAAAGATATATTTTGACTTCTTCTTTTCCAATTTGTATCCCCTTGATC


TCCTTTTGTTGTCGAATTGCTCTGGCTAGGACTTCAAGTACAATGTTGAATAGGTAGGGAGAAAGTGGGCAGCCTTGTCTAGTCTCT


GATTTTAGCAGGATTGCTTCCAACTTCTCACCATTTACTTTGATGTTGGCTACTGTTTTGCTGTATATTGCTTTTATTATGTTTAGG


TATGGGCCTTGAATTCCTGATCTTTCCAAGACTTTTATCATGAATGGGTGTTGGATTTTGTCAAATGCTTTCTCCCCATCTAAAGAG


ATGATCATGTGGTTTTTGTCTTTGAGTTTGTTTATATACTGGATTACGTTGATGGATTTCTGTATATTAAACCATCCCTGCATCCCT


GGGATAAGACCTACTTGGTCAGGATGGATGATTGTTTTAATGTGTTCTTGGATTCAGTTAGTGAGAATTTTATTGAGTATTTTTGCA


TCGATTTTCATAAGGGAAATTGGTCTGAAGTTCTCTATCTTTGTAGGATCTTTCTGTGGTTTAGGTATCAGAGTAATTGTGGCTTCA


TAGAATGAGTTGGGTAGAGTACCTTCTACTTCTATTTTGTGGAATAGTTTGTGCAGAACTGGAATTAGAACTCTGCACTAAACCCGT


CTGGTCCTGGGCTTTTTTTGGTTGGGAGACTATTAATGACTGCTTCTATTTCTTTAGGGAATATGGGACTGTTTAGATTGTTAACTT


GATCCTGGTTTAACTTTGGTACCTGGTATCTGTCTAGAAAATTGTCCATATTGTCCAAGTTTTCCAGTTTTGTTCAGTATAGCCTTT


TGTAGAAGGATCTGATGGTGTTTTGGATTTCTTCAGGATCTGTTGTTATGTCTCCCTTTTCATTTCTGATTTTGTTAATTAGGATGC


TGTCCCTGTGCCCTCTAGTGAGTCTGGCTAATGGTTTAATCTATCTTGTTGATTTTCTCAAAGAACCAGCTCCTCGTTTGGTTGATT


CTTTGAATACTTCTTGTTTCCACTTGGTTGATTTCACCCCTGAGTTTCATTATTTCCTGGCGTCTACTTCTCTTGGGTGAATTTGCT


TCCTTTTGTTCTAGAGCTTTTAGGTGTGTTGTCAAGCTACTAGTGTGTGCTCTCTCTAGTTTCTTTTTGGAGGCACTCAGAGCAATG


AGTTTCCCTCTTAGAAATGCTTTTATAGTGTCCCATAAGTTTGGGTATGTTGTGGCTTCATTTTCATTAAACTCTGAAAAGTCTTTA


ATTTCTTTCTGTATTCCTTCCTTGACCAAGGTATCATTGAGAAGAGTGTTGTTCATTTTCCACGTGAATGTTGGCTTTCCATTATTT


ATGTTTTTATTGAAGATCAGCCTTAGTTCTTGGTGGTCTGATAGGATGCATGGGATGATTTCAATATTTTTGTATCTGTTGAGGCCT


GTTTTGTGACCAATTATATGGTCAGTTTTGAAGAAGGTACCATGAGGTGCTGAGAAGAAGGTATATCCTTTTGTTTTAGGATAAAAT


GTTCTGTAGATATCTATTAAGTCCATTTGTTTCATCACTTCTGTTAGTTTCACTGTGTCCCTGTTTAGTTTCTGTTTCCATAATCTG


TCCATTGATGAAAGTGGTGTGTTGAAGTCTCCCACTATTATTGTGTGAGGTGCAATATGTGCTTTGAGCTTTACTAAAGTGTCTTTA


ATGAATGTGGCTACCCTTGCATTTGGAGCATAGATATTCAGAATTGAGAGTTCCTCTTGGAGGATTTTACCTTTGATGAGTATGAAG


TTTCCCTCCTTGTCTTTTTTGATAACTTTGGGTTGGAAGTCAATTTTATTCGATATTAGAATGGATACTCAAGTTTGTTTCTTCAGA


CCATTTGTTTGGAAAATTTTTTTCCAGCCTTTCACTCTGAGGTAGTGTCTGTTTTTTTCCCTGAGATGGGTTTCCTGTAAGCAGCAG


AATGTTGGGTCCTGTTTGTGTAGCCAGTCTGTTAGTCTATGTCTTTTTATTGGGGAATTGAGTCCATTGATATTAAGAGATATTAAG


GAAAAGTAATTGTTGCTTCCTATTATTTTTGTTTTTAGAGTTGGCATTCTGTTCTTGTGGCTGTCTTCTTTTAGGTTTGTTGAGGGA


TTACTTTCTTGCTTTTTCTAGGGCGTGATTTCTGTCCTTGTATTGGTTTTTTTCTGTTATTATCCTTTGAAGGGCTGGATTCCTGGA


AAGATAATGTGTGAATTTGGTTCTGTCGTGGAATACTTTGGTTTCTCCATCTATGGTAATTAAGAGTTTAGCCGGGTATAGTAGCCT


GGGCTGGCATTTGTGTTCTCTTAGTGTCTGTATAACATCTGTCCAGGATCTTCTGGCTTTCATAGTCTCTGGTGAAAAGTCTGGTGT


AAATCTGATAGGCCTGCCTTTATATGTTACTTGACCTTTTTCCCTTACTGCTTTTAATATTCTATCTTTATTTAGTGTATTTGTTGT


TCAGATTATTATGTGTCGGGAGGAATTTTTTTCTGGTCCAGTCTATTTGGAGTTCTGTAGGCTTTTTGTATGTTCATGGGCATCTCT


TTCTTTAGATTTGGGAAGTTTTCTTCTATAATTTTGTTGAAGATATTTGTTGGGCCTTTAAGTTGAAAATCTTCATTCTCATCTACT


CCTATTATCTGTAGGTTTGGTCTTCTTATTGTATCCTGGATTTCCTGGATGTTTTGAGTTAGGATCTTTTTGCATTTTGTATTTTCT


TTGATTGTTGTGCCCATGTTCTCTATGGAATCTTCTGCACCTGAGATTCTCTCTTCCATCTCTGTATTCTGTTGCTGATGCTTGCAT


CTATGGTTCCAGATTTCTTTCCTAGGTTTTCTATCTCCAGCGTTGCCTCACTTTTGGTTTTCTTTATTGTGTCTACTTCCCTTTTTA


GGTCTTAGATGGTTTTATTCGATTCCATCACCTGTTTGGTTGTGTTTTCCTGCAATTCTTTAAGGGATTTTTGTGTTTCCTCTTTAA


GGTCTTCTACCTGTTTAGCAGTGTTCTCCTGTATTTCTTTAAGTGAGTTATTAAAGTCCTTCTTGATGTCCTCTACCATCATCATGA


GATATGCTTTTAAATAGGGGACTATCTTTTCAGGTGTGTTGAGGTGCCCAGGATTGGGTGGGTTGGGAGTGCTGTGTTCTGATGATG


GGGAGTGGTCTTGGTTTCTGTTAGTAAGATTCTTATGCTTGCCTTTCGCCATCTGGTAATCTCTGGAGTTAGTTGTTGTAGTTGTCT


CTGGTTAGATCTTGTTCCTCGGGTATTTATGTTAGCCTCTATCTGCAAACCTGGAAGACTAGCTCTCTCCTGAGTTTCATTGTTCAG


AGTACTCTCTGCAGGCAAGCTCTCCTCTTGCAGGGAAGGTGCCCAGATATCTGGTGTTCAAACCTGCTTCCTGGCAGAAGTTGTGAT


CTACTCACAGAGGTCTTACGATCCCGTGGAGGGTCCTATGTGTACCATGCAGGTGTCTGCAGACTACGTGCCCAAGGTACCTCGGTG


CTGGCGTGCACC2GAAGGGATTTGTGCCCCTGGTCAGGCCGGGTTTTTTGCTTCCCCAATTAATGCAGTCTCAGGTCCAGCACGATT


GGATTGGAGTAGCAGCTGTGTTCCACTCACCAGAGGTCTTAAGATCCTGTGGAGGGTCTTGTGGGTAGCCTGCGGGTGTCCACAGAC


TCCGCGCCCAAGCTACCCCAGTGCTGGTGGGGCACTTCATGAATTCTTTAAAGGAAGAAAAATTCTATTCAACTTGTTCCATATGCA


GCTGTGGGAGGTACAGACAATGCATCTCCTTCTTGAGGGCTTGCTGCTTAGCTAGCTATAAAAACATACACAAGTAGAAATGTTAAC


ACATGAAGTACTGGTTCGTTCCTCTTAAGTTTATACTGTCCTCTTTAGGAAAAAGAGGAAAAGAAAAGTTTCCTCAATTATGATACA


TTTAGAAAGAAGCAGCCGCTGTTACATGAGTACAAATTCCAAATGGCTCTGAGCCACATGCCTCATGGGTGGATCTATGTCTATCTA


TCTATCTATCTATCTATCTATCTATCTATCTATCTATAGATCTATAGATCTATAGATCTATAGATATAGAGAGAGACAGAGAGAGGC


AGAGAGACAGAGAGAGAGAGACAGGAGAGACAGACATAGTGATAGAGATAGAGATATTTCTTCCCTTTTCCATCCTTTAAAACCCAA


CTCCTGTAAGTGTCTGTATAAGGCCTTGGCTGCAAACTGATATAAATGAAGAGTGTAATTCAATTCAAATAGTGGCATCTGAATAAA


TCTCAGGTGGGATTCTGACCGCATGAAAGGAAACTCACACTTCCCATTTTATAGATCTGGATGACCACAGATTCTATCAGAACTTGC


TCAAAGTTGGTAGGACACAGAATCACATCCACTGACCTCAGGAGCTCCTGGGCCAAAATACACACAGGCACAGTATACATATGGCCA


TGGCATGTGGTATGTGTGTGTGTGTGTGTGTGTGTGTGTATGTGTGCGTGTGTGACTATTCTTTATGTGTTATCTTTGAGTGGAGTC


AGTCTCTACAGTTGTTCACAAAGCTCTCAGAAGTAGCCCAAGATTGGCTTCTTCTAGTTTAGCTGTGACATTTGTCCAGTGTGTTAG


TGTCTTGGGGCTATAGTAATAAAGCACCAGAAATGTGAACTTCTCAGTTCTGCTGATGGGGAATCTGAAATTATGGTGACAGGATCT


TGTGGGAAAGCCTGTTGCCTCTTCTGACTCTGACTTAAGCTAGCTGCTGACAACACTCTGCAGATCTCTTTCCTCCTCTTCTTCTTT


ACCTCCCTCTGTGTGTGGATGATCTCACCCCAGTAATGTAGTTGCTTATATCTCTGATCACCCTATTTTCAAATAGGGCCCCCCACC


AAGATTAGAGGTGGAAGTAGATTCCTTTGGGTGGGTGAGGAGCAGGACGTACACCATGCTGAACTGTCACTCCCCACCAAATCTGTA


AGTTGATGTCCTGCTCCTTGTGTGGGGTAAATTGTTCTTCCTCCCCAGCTCATAGGATAAAGTTCTAAGTCTTGGTACTTCAGAATA


TGGCTATACAGATGTAGATGTTTTAAAGAGGAAATTGGGTAGGATGAGTGCTGGGTAGGATGTGGGACTGGGTAGGATGAGTGCTGG


GTAGGATGTGGGACTGGGTAGGATGTAGGGCTGGGTAGGATGTGGGCTGGGTAGGATGTGGGCTGGGTAGGATGTGGGTTGGGTAGG


ATGTGGGACTGGGTAGGATGTGGAACTGGGTAGGATGTAGGGCTGGGTAGAATGTAGGGCTGGGCAGGATGTAGGTCTGGGTAGGAT


GTAGGACTAGGTAAGATGTGGAACGGGGTAGGATGTGGGACTGGATAGGATGTGGAACTGGGTACGATGAAGGATTAGGAAGATAGC


TCAGTCAGTACATTTTTTACCTTGCCTCTATAAGGACCTGGGTTAGATCCCCTGATGCATACACACAAAGCCAGGCATGGCAGTACA


TTTGTAATCCCAGTGCTGGGGAGGCAGAGACAGGTAGATTACTAGGGTTCACTGGCCAGACAACTTAAATATACTTAGCAAGATTTT


GTAGAGAGAGAGTGCTAGAGACCCTGTTTAAAAAAAAAAACTAAATAAAACAAAACAAAAACCAAACAACAACAACAAGAACAACAA


AACCAAACAAAAGGAAAAACAACAAGAACAACAACAAAAAGGTGGGTAGCTTCTACGGAATGCCGCTGAGGTTGCCCTCTGACTCCC


ACATTCACATGTATGTATGTGTATACCCACAAACACCCAGCTGGTGGGCCTTAATCTAATCTGACCAGAGTTCCTAGGATAAATTTG


GGTGCTAAGGTATAAAGAGGAGGTTACATAGTGAGGAGGAACAAATAGCCAGGGAGAGACGCTTAGAGGAAAGCCGTTTTGTCAACA


CCTTGATTTCATGTGTCCAGGGTCTAGGTCTCCCAGAAGGCTGATTTTTGTTTAAGTCTCTCAATTAACAATACTGTGTGGCAGGCA


GTCTTGGCTGCCACTATGTTCAATCAAGCATACCATGAAAAAATGCAAGGAGCCAAAGTAAATCTAAATGTCTTTGCTCACCACCCC


AGACAGTTCCCGTGTTTCCTAAGAAGCCACTTGATGAACTGATGTGGTTGTTGTTCTTTCTTCTCCAAAGGTAACAGCATCGGGATC


TTTGAGGCCCATGATATGGACGAAGCTAACAACATCAACAGTATTTTGAAATACAAGCTTGTAGACCAAACACCCAAAGTTCCCTCA


GATGGACTTTTTCTCATTGGTGAATATGAGGGAAAGGTTCAGTTAAGTAAACAGTCCTTGAAGAAGCAAGACAGTCCTCAGTACAAC


TTAAGTATCGAGGTGTCTGACGTAGGTAAGCACTGTACCCGATGTGGTGAGTTTACATGTCTGTTTTCCTTTTACTAAGGATTTGTG


AGGCCCTTCCCATGCCAGTAGCTTTCTCTGCTATCTTTGTGACTGTGAGGAAGCCAGATGTTTTCTCAAGAGCTAGAGGTGCAGATT


CGGAGACATCGCATTGTCTTTGGTCCTCTGAGAACTAGGTGTCAAGAGGAATTCAGTGACCATCTTAAAGAGAATGCCCTTAAGAAA


AAATGGAAAGGAAGCTTCGAAGTCTAGGGGATCCCCAGACAGCAGTTCTGGCTTGATCAAGATGGAAGGAGTTTTGATAACAATGTT


CTAGACCACTGAGCAGTCTAAGAAGAATTCCAAATGGTTATCGGGAAGGTCTGATGCAGGGCATTGTCTCTGTGGATAGGCCTGTCT


TTGCATCACTACTTGCTCAGTAACCATCTGGGGGCAGCAAATAGAAGATGAGGTACAAGTGTACTGTTGGTCACAGCATAACACTGC


AGCTACCAGGTTATCAGTCCAGCTGTTAAAGTCACCAGGCGCAGTCTCACAGCTACTATAATTAAAATTCAGGAAAAATTCTTTCCT


CATCCTTGCTTCCAGACTAAAAGTATCTGTGTATGAAAGCAGTAGAGAAATTAGTCTTTGCTGTTCTTGAAGGCAGAGAGAGTTCTG


CCCTTTCTTGCCACCTTCGTATTGCCCACTAGACAACAATAGGAAACCTTTCCCCTTAATCCTTGTATACTATCTAAGTGGGTTCTG


CTTAACCTCTCCTCTCCTTAGGGCAGAGGAATCCTTAGAATCTTATGGCAACTTCCCATTCTTAAACACATCTATACATCCACAGAC


AAATTCGCTGCTATCTCTAGGGTACTCAGAGTCCTAGGAGGTAACTGGCTCATGAAATGATTCTGTAATTGTTTTCTGAGGAACACA


GTTTACATAGGTGTGGAAAAGAAAGGACCAGTGGTTCACATGTATTTCTTATTTTTTTTCCCCTTTCCCATGGACCCTGGGAGAACT


TGAGAACTTGAGTTAAACAGGTTCCAGTGCAAACTGCCTGTCAGGTTCTCAGGTAGCTAGTGAACTGACACACGATGAAGGTCTGAT


GCTGTTTAGCACTATGTTAAAAGATCCAGTGAGATAAATGTCAATCATGCTATCCATGGCAAAGGGGCAGACTCTCCCTCACATTGG


CCACCCACACATTCAGTATTTAATCATTTGCCTTGCTAAGGTATCAAAGTATTAGGCATGCACAGATGAACTGGACCCAGTGTTTGT


CCCTAGGGAGTACCCCTTTTGTCAAGAAAGATGGACACACATGTTAACAACTTGTAGGGACATACTATCTACTGTCATTGTGGTGCT


CTTCGTAAACACTGTCCCACAACTCATCTGCAGGCCACACTCATCTCGAATCTAGGATCCACTTGCTGGTTCCAATTAGTCCTAGAA


TTGTCAAACCACCCTCTAAGCCTGGACCATTTCTGTGAGCTACCTTAGCCTCCCTTGGAGGTGAATTATGCCACTTTATTCCTTACT


TGGAGAAGAGGAAGCAAGTGACCTTGAACCTCTCTACCATGCTGGGTAGACACATGCAGAGAGGGAAAGGCAGCCTGTGGGGTGTTC


AGCAGAATTGTGCAAAGGGACAGTTTTGCTTTGGGCATCAGAGGTTATATAACATTCACCTGTCAGGTAAGGGAGCTGCTTCAGAGA


AAAGCAGCCATCCTGGTTGTTGAAAAGCCTTCCCAAGGATAGGGCAGAGGGATGCTCAGGAGAGACTCTCAGGGCCCAGTCTGGCTT


CCACTTCCTCTTGTTGACCTGCTTGTGGATGAGGTGGTGGTGGTTGGGGTGGGGGGCAGAGCAGCCTCCATTCACAGGAACTGTAAA


GTTATAGCAGCAGCTACTGTGTCACTTGTCAATGTTTCCTTACCAAATCCTGATGCCAATGCATGATTTCCAGTGAGAATTCTGTGG


TGTGACTTTGGTTTTCAGATTTCAAGACTCTCTGTTATATTCAAGTCAACGTTATTGATATCAATGATCAGATTCCCATCTTTGAAA


CATCAAATGTGAGTAGATATCACTATTTGTTTTATTTGGATCATATAATTGAACCCTTATTTAAATAAAAACACAGACAATGTGCCA


GGTAGCCTGCTCAATGCATCAATAAAAATCAGGCACCATCTTCACGTGAGTCCTCAGGGGCCCTAAGGTGTACTGAGAGTAAGGAGG


GATGTCTATTTATAAACTCTTGCCAACAGCTCATTTATTCTAAATGAGGCTTAAAGGCTACAACCACAATCCTTTTCAGATTGAAAA


TTAAATGGCTGCTGGTGGCTTGTTATAGATTTTGCATACAATGGACAGTAGCTAGAGCTACAAGATCTATGCCAAGCATTTGGGATT


TAAAAAATTAGCATCAGAAATACTGGTGACTTTAACTCATTTAGTATTTAACCAAGTAAGAGGAAAGGAAAGGGGAAAAATATTTCT


GGCTTAAGCCTAAGAGAAATGTGCTCCCTATATTTGCAAGAATTAGCGTTGGACGTAGAGTAAGTGTCAGGGCAGAAAGGACGTCAG


GGAAAATGGCTGTGGTCACAGTGTGGTGTTATCATTGTACCCTTAAAAGGAATGTCTTGGTTTATTTAGCTCCAGGGAAAGAGAAGC


CCACTTGACTAGATTGTTATGTTAGAAGTCAGTTTTGAGGCAGCCCAGAGCCTCCTGATGATGTCCATAAATCAAAACAGAGGCAAG


GCTGTAACAAAGAAGGGAATTAATTTACAGTAGAGCTCAGAACCGTAAGAAGTGTGATGGAACGTATCTTGTCTAACAGCCACTGAG


CTTAAGTAAGCATGAAATAAAGTATTCATTTTTTTCTCAGCCTCTATCCTCTGAGGCATTTTTCACTTCCTAGTATTGTGTGTCCCC


TGCATTTCAGCAGACAGTGGTCAAGTAGATTGAGCAGAAGAATTCTGCAGTGGGGAGTTCAAAAGCTTGGAGATGCAAACCTGGCTG


GAGAGAAAGTGGGCTTGCTTAGTCCATTGCCAGCGTCTTCTCTTGGATGCTGGCTGGTACCATTTTTGAGGTCATGATGTGGGGGAA


GAGTGGGTCATGGGGCTTCAGGGGAGTTAGAATGCTTTGTGGGGTGTGAGGAACACAGGCTTTGGTGGTTTGGGTTCAATCATACAA


GCTGTTAGCCTGGTGTGTGTGTGGGGTTGACTATGCTAGTTCTTGGCTCCTCTGTCAAATGTCACTGACATGTTTGTAGCCCTCTAG


TGTACTTTGCTGCTCATCTTTCATAAGGGCTGTATACCAGCCATTCAGAGGCTCTGCATGCATTATCCCCTAATGACCACAGGTTGC


ATTCTCTTAGTTGACAAGTGACAGAGCCCATGTTTAAAGAAATGAGATAACTGTATCATTCAACTAACAAACAGCAAGTTTAGGGTT


AGTAGCCAACTCTGACTTCAATGTTTTGGGTTCCTAATGTCCATCACTTGGTTGACTCAAGAATTAGAAGTATCTGTCACATCATAA


GGACTTCTCATGTTATGACTACCTATATCATTATTTTTCAAATAATTATAGTTATTAAACATGTGGATATTGGAGGGGAACTCTATT


TTAGAATCCTTGTAGAATGTCTAAGTTCTATAAACTTAGTTTAGTTGGTATAAATTTCGGTTCATGAGTACAAATGATGTCAAACCC


GACTGTCACATGTTCATCAAGAGGAAAACCATGCTGGGTATTAAAGCCAGCTGTGACCTCTGTCCTGAACCCAGAGACGTTTGCCTT


TTGTCCAGTAAACTCAATGCCATGGACCTTCTGCTTCCTTTCTTGTTTCTTCCTCAGTATGGAAGCAAGACTCTGTCTGAAGACACC


GCCATCGGATCCACCATCCTAATCATCCAAGCTACAGATGCTGATGAGCCCTTTACAGGGAGCTCTAAAATCCTGTACAAGATTGTA


CAGGGAGACACGGAGGGAAGACTAGAAGTTGTCACAGATCCCACGACCAATGCAGGATATGTCAAGATCAAAAAGGTAGATATCAGC


CGGGCAGTGGTGGCACACACTTTTAAGCCCAGTGCTTTGGAGGCAGAGGCAGGTGGATCTCTGAGTTCAAGGCCAGCCTGGTCTACA


GAGTGAGTTCTAGGACAGCCAGGGCTACACAGAGAAACCCTGTCTCAAAAAACAAACAAACAAACAAACAAACAAACAAACAGCTAT


CCCACATAATAATTGTTAACAAAATAAATAAAATAGATTATTCTACTCACAATTATGTCAGGACCAATAGGCAGAGGTAACATGTGC


ACATGTACACAGAAGTTATCTGATGTGGATACTGGGAACCAAACTATGATCTCTGCAAATGTTCAACTGCTAAGCCACCTCTCTAGC


TCCCAAGATGAGACTACAGACAGATATTCCTTATGTGAGTAAAATGGCCATGCATAGAATTAATCAGGAAGGTGAGCCCAAGTTTTA


AGACAGAGGAGACAGATGTGAAATGAAGGAAGGTGACAGACTTTTATCCTGATTTTAGTTAGCTTATGAGTCTGAGTGAGGGGCCAG


TGCTTTTCACCACAAGGAATTATGAAGAACTGCAACTCCTTCCTTTACCATGTTTCTAAGCCCAGTTGGCTCTTTTCTCCTTTCTAT


AGACTAGAGAGTTTGGAGATACAGTATTAACTCATAGTCTCGTCTTCCTCCAGGGTCTCTGCAACTTTCCCCCAGCCTTTTCTCATC


CCTCACTAGGTACCTGAGTCTCAAGTTTTCTCTTCTGTAACTGCATAATTTGTGTTAGAGCTCACCATGGGATTACCAGATAACTCA


TTTGGAACCAACACCACCCAATGGGTGTTGAGTTAAAGCACTTCCCATGGGGAGAGTCCAAAGCCTTCCAGGTGAACAAGGAGAGGT


TCAACAGAGAATTGGTTGGAATGCTGCTTGTTGGTTGGGGCTGAAAAAAAAAAAGGCCCAGGAAATGTTTTTAACTAGAGCAATGGA


AAGTTGAAAATAAAGAATAAAAGTGGAGGCCAAGTAGAGTGGTTGCACAGAAAACAAAAAAGAGCCAAGGAAAAAAATAACGCCAGC


CTGGAACCAGCCATTGAATTGCATCAGCTATTTGGATGCGAACTGTTGCCCATAGTCTCATGTGTTTGGACACTTGGTCTCAAGCTG


GTGGTGCTGTTTTGTAAGGCTATAGATCCTCCAGGAGGTGAAGCTTTGCCTGAGAAACTATGGCCAGAGCTAAGAAGTTTAATGGAC


CAGCCTTGCTTCCTATCCATTCATTTGCTTTCTGATAGCAGACACAGTGTGATCAGCTATCCCTTTCTTGCTGAGATGGGCTGTGTC


TCTTCATAAGCTGTGAGCCAGAGTAAACTCTTCCTCCCTTAAGCTGCCTCTTGTCAGGTATTTAGTGACAACAAGAAAAGAGTATGT


ACTGTCCCCTGTACCACATCTGACAAGGGTGCTTAATGGGTTCAGCAGAGTTCAGTGTATTACACCCATAACCTTCTGTGGAAGCCT


GATATTTGGAGAACATATGATCACAGCTTCTTCTTCTTCTATACTTGGCTATTTACATGAAGAAAGAACATGGGAAGGATGGAGGAA


GGGGTGCTTTTCATAATTGGGAGTGGGTAGTCTGCAAAGCATGAGTCTTTGCTTCAGGGCCGGGACATCTCTCTCCTCCCATCACTC


TAGGGACTCAGAGAAGATAGGAAGATGTCTGTCCCAGTAAACAACTGCTGCATGTCATTTTTTTCTTTGTGGTAGCTTATCATGTAG


CATCCTCAGCTTACCTGACCATGTGTGGTGATTGGATCCTTTAGGGAGATGATGGTAGTGGAGAACTATAGCTGTACTTCCACATAA


GTCATATATAAGGTACCATTATAGTGGTGCCAGGCCACTCACTGAACACTTGCCATCCTTGTTTCATGTATTGCTGTATTTACAGTG


TCTAAAATATTGCTTGACACATGGCAGATGAAGATATTGAGTATTGCTTGACTGAATGAATAATTGAAATTTGTTTCATGTCTAATT


TCTAATAATCACATAGCAATAGTATAACCTCTGTATTAGGAACCTGAAGTCTCAGCTCTCCGTTCCCCAGGCACTGTGACTACAGAA


CTTGAGTGTCAAAATTTGGCAGGCTGATCATTGGAAGGTAATCTCAGAACACAGCTGGAGTCCTGGAATTCTGAAGGTCACAAGCTG


TACCAGAGGCTTACACTACTATTGACAATGACACTGTGTTTTTAGCCACACTAAGTACTTAACAGTCTGTCCTCCCATAACACCAAG


CATATCTCTGCAAGAGCATTTTGGTAACGGACATACACTGTGCTGATGGGCAGAGTAGCTGGAGATTTCAGTGGCTCCTTCTGGAGT


GTGGACCTCAGATTAGGCTTTTTGAAGTGCAACAACCAACCCTCAGGGATGACTTTTAGCTCACTGGATGCAGAAAAAGATGTCATC


ATATACATATACATACATACACATACACATACACATACACATATACACATACATCACAAATATATATATCACAGATATATATATATA


TCACAAATATATATATAATATTTATATATTATTTATATAGTATTTGAGTGTGGACTTGGCATCAGTGTATGGTTTATACATGTGTGG


GTGAATTCAGGAGGCCATGGAAGGATGCTGTATATTCTCTTGTATTACAATTTTCTTTCCATCGAAACTCTCCAGGATGAAGCCTAT


GTACCCTCTAACTGATGTACTCTGGGTACTGTTTGTCAGGAAGGAGATAAAAAGTGAGGTGACTATGCCCCAGTCCTTCCTTTCAAC


AGGAGTCTGAGGGTTATACTAGACATAGCTTGAGCATATATAAGACCTCAAAACCCACCCCTACAGTGACACATTTCCTTCAACAAG


GCAATACCTACTTCAACAAGGTCAAGCATTCAAATACATGAGTCTGTGGGGGCCATTCCTATTCAAACCACCACAATATTCTTTTGG


GCTTTGCATTGGTTCTGTTTAGTTTTTGATGTTTTAGGTCCTTTTAAGAATCTGACAACAACAACAACAACAACAACAACAACAACA


ACAACAACAACAACAACACACTACCTGACTATTTGACTGGGACTGGCAAGATGGCTCAGTGGATGAAGGAACTTACTCCATAAGCCT


GACCACCTGAGTTTTATCCACATGGTAAAAGGAGAGAGCTAACCCCCACAACGTAGCCTTTCATCTTCGTACATGTACTATGGGATA


CATGTACCAACATACATATACATACACATACAAATAAATAATGGAATTTTAAAAGTCTACGTGCCTCCATCTTAAAATAACAATAAT


ACACACACACACATGCACACACACACACACGGAATGTTTAGATTTTAGTTCACAGGGGTTCAGAGTCCTATGGGATTCTTGAGTCTT


GAGATGGCAGCCTACACTGCAGGAGCTATCATTTCTTGGTCTCTCGTCTCCTATAGAACAATAAATTCCTGCTTAGAGGGGGATATG


AGGTCTCATAGGGCCAGTTGCTCATAGGATAGATACATCTTTCTGTTCTGTTGCATATAGTTAAGCATATCCTTGAAAAGTTACAGA


ATTTGGAATGAATTGTTTTCTGAACCAACTCTTACCTTCCTTAGGTAGCCTGGTTGTTAAATTCTCCCTCATACAGAGCCAGAAACA


ATGCCTTGTTCTTATTACTGGTCCTGTCTATCCAAGTGGACCAAAAACACATCCTCCTGCCGGCATGGCCTCTGCTCACCTCTCCCA


GAGTCTCATGTTTGGGGTCTTGGGTTCTGAAATCACTGGAAAGTGATCCTCCATACCATGTGAACATCTCTGTAGTACAAATATTTT


CCTAGATGCCATTGTCTGAGGAGAATCGAGATTTTTCTGAGAAGACATGTAGGGTGTACCAGGGTTAAATGAATCTGAGGAGGGCTG


TGTTAGAGTCTCTCTTCCTAGACAGCCCATGTACGTGAAACCACTTAATGCCCTGATGGCACCTGAAATAAAGTTGTGTTATGGATT


TCTTGATATGAAGGTTTCAACTAAGATTTATGAATTTTTTAAAAAATAAATCCTTTAAGGGGGCTATTCACCCCAAGATTAATTTCC


CCTTGTTTTCTCTCCCTCCACAGCCTCTTGATTTTGAAACTCAACCAGTTAGCAGCATTGTGTTCCAAGCGGAAAATCCTGAGCCAC


TGGTGAAAGGCATAGAGTACAATGCTAGTTCTTTTGCCTCCTTCGAGCTGATTGTGACGGATGTGAATGAAGTGCCTGTGTTCCCCC


AGCGAATATTCCAAGCAAACGTCAGCGAGGATGCTGCTGTGGGCAGTAGAGTGGGCAACGTGACTGCCAGGGATCCTGAAGGCCTGA


CTGTGAGGTACAGGGCAGCAGGGCTGGACAGGCCTACTTGCATGCTGCAACCATAACCAGAAGGAGGGCTGGCAAGGCAGAGAAGCA


GCGTGCCCTGACTTCAGGACTGGGGCAATGAAGCAGACAGCAGAAGCAGGGTCTCTGGCCTTGGTTCAGTGTGTCAGACACATGGCT


TCAGGTGCCAATTCTGTCTCCTTGCTGCAAGCTTCATTTGAGATCTGGTGAAGGTAGTAGGTGGGAACCCCACTCCCTGAGATTGGG


TGAGCCATGGCTAGGCCCTAGGTTTGAACTATTGGGGTTCTAGAGAAGCTTCCTGGGGAAAAAAGACTGGAGTTGTAGAGAGAGAAA


CACCCAGAAGTAGAGAAAGCCACCCTAGAGGCCAAAGGGAATGTTTCAGAAGTAGGGATTCTGGGCTTCTCCTCTCTCTGGAGAGCT


AGTCTGGGGCTAGTCTTCCCCCTCATTCCCAGAGGGTTAGTGCTCAAGGTGAGATGCTAAGACAGCATTTCTGTTTTAGCCATTCTC


ATTCCTTCTTTTTCGATGCTACTGTCCCCACACATATTTGCCTCAAAAATGTACAATGATTAATTCATTTACTATATACACATATAC


ACATTTGTATAATACCTAAATGATTTTAAAGATCACATAGTTAGTAAACATAGATAGGACTTGAACTCAGACCTTTTGTTTGTCTTA


TACAATATTCTCCAGAATATAAACAAATAATTCCACATGACTTAGCTGGTACAAGTATTTCCAAGTCTTTAAGTTTCTCTGTATACT


TGAGTGAAGTTGTATCTCCTATCGAGCTGTCCTATAGACAGTTGGGTTCAATTATATGGGCTTTACTGATTTTCTTGCATGAAATAT


ATTATTAGTTTGCTTACTATAAAAAGAGTGTGAAGCAGAGAAACTTTATAAAGAAAACCAGTTTATTCAGTTCATAGCTCTGGACAT


TTATGGGCATAGCACCAGTACAGGCTGGGTCTGTTGAAGGTCAGTGTGATTATTAACACAACAGCAACACAAGCAAAGGGAAAAGAT


CACATTGTAGGCAGGAAGCTGTAGCCACTGCATTCTCACAACCCCTGCAAGGGAGTGTCCCTAAGTGATGCAAGACATCCCACTAGA


CCCTACCTTCAACGGTCCTGTATTCAGCAAATTTACCATCTGAGAAGGAGGCTTCTAACACGAGAACAGTTTTTGTGGGGGAGGGGG


AACACTCAAATCATGTCCATATCATACTGAGGAGTAATGTTCCCACTAGTGAGGATTATATTGAATTATTCAGTGTAGAAACAATGC


TATACATCCAGGTCACAAGTCATGATGGAATTCAGAGCCCATTACTATCTAACCAATGCCTCTGTATTCTCTGGGCGAATGCTATAA


AAATTTGCTGATTGTAATGAAAAGATAAAATAAATCAGTAAAATTACTGGCCAGAGGTATGTGCACGTTAGTATAGAGAAACAGAAG


CATTTAAGGAAATTCCTCTGTTGTCTCAAAAACTGGTATAGAGCATAAAACCAGAGTTACCATCAGATGAGACGGGCAAGGGAGACT


GAGAAAGGGCATTCTGAGAAGAGGCATTCTATAATGTCTGTTTCTGGAAGCACGTGAATGAGGAGTAATCAAGGCAGCCAGGGGCAC


ATGACAGAGTAAGAGCTAACTTTATGGACTCTGACATTGTGGACTGGGAAATTTAACTCTCCAGCTGGGTAAACCTAGAGAGTCGAT


CAGCAGATTCAAATCCAACCCACCTTCACATATTATAGAGCTCATTGCAGGCCACAGATCTAGAAGCCACACCTTTCTGACTACTTC


CCCTGTGGTCCACAGCACTGCCATCTCTGTTGTGGACCCATCCTTCCCCACCACTCCATATCTCATTTGAGTCAACTGTGCACTGCA


GGCAATGAGAGCCTTTAAGATGAAGTAAGCTGACTGTCCAGCTCCTCTTCTGAGCTTGCCCTGGGATTCTTGCTTCTGTCAGGGTTG


GATCCCAAGTACTTAGGAGCTCAATTTATCATTCACACAAAATCATCAATACAGTGCTTGACATATGCAACATGCTCAAAATATACA


TGGGAAAATTAATTTGACTAAATATAATTTTAATCATTCATATTCCTGGACATACAAACTAACAGAATTTTAGAAAATTGTAGGCAG


TCTTTTGAAGTCACACACACACACACACACACACACACAATTCCTTGACTCCTATTAAATATTTATTGAGGTGACATTTCCAGGACT


GGAAATAAGTGGCTTGCAACTATAGACATCTTTACAGACATATGTGAGGCTTTACAAAAAGGCTAAATTTACTGGCTTTTGTCAGAC


TTGTTTCTCTCAAATTTATCTTTCCTACACCCACCAATGAATTCTGTTGAGGACACCATTTCAGCCAGGTCACCTTTCCACTCAGCA


TAGCTCGATGGCTACCTCTGGCTTGTATGATCTGGCTCTCCCAGTCTCTGTGGCCACATCTTTTCCACTTACTGCTGCCCAGACATA


TCCATGTACTGTGCACACACCAGGATGCTCCTGGCCTCTCTGCTGGTTTGTGTATCTTTGTGGCACCCTTCTTGTCTGTGTCAACAT


CTTCAGAAAGGCTTTTCTAAGTCTAAGTACTGGATTATCTGTGTATCTAAAGGCTTCATTCTTCAATTCTTGTCTCACCCCTGTCTG


CTGGAGTTGATGCTTCTTTAGTGAAGTTTTGCCAGGCCACCAGCAGCCTATGTCTCCAACATTACTTGCTCAGGTTTCCTTAGCAGG


GTGGCATACTGACAGCTTTCAGAAGACATATACTTCAATATGAAATCTTGATTGCCAGGAAAGCATAACTTTTCTCCCAGAGCTGGT


CACTTCGCCATACATAATAAAACAAGCATAGGACCATGTTCTAAGGCAGTGGTTCTCAGCCTTCCTAATGCTGCCACTCTTTAATTT


AGTTCCACGCGATGTATGACCCTCAACCATACAATTATTTTCATTGCTACTTCATAACTGTAATTTTGCTACTGATATGAATCATAA


CATAAATATCTGTGTTTTCAGATGGTCTTAGGTAACCCTGTGAAAGAATTCTTTGATCCCCAAAGGGGTCACAACCCATAACTTGAG


AACCACTGTTGTAAAGACAGCTCTTTTTCCAAAGAGAGATGTGTAAATGAGATGTTGATTCTGTGATTCTGCGATTCTGCTCCATAG


GACACCCAAATGATGATTCTATGTCGGTGTATAGAAGCACAAAATGTTTTCATGTCAAGTAACACAGGTTTTTTTTTCTGCTCTCCC


CTAATGAAGTTATTCACTGAAAGGCAATATGAGAGGCTGGCTTAAAATCGACTCTGTCACTGGTGAGATATTTAGTGCTGCTCCGCT


GGATAGGGAAACAGAAAGTGTGTATCGAGTACAAGTGGTGGCCACTGAAGTAGGTGAGCAAAACAAAGCACAACCAGATCACAGATT


ATCAGGGGTGGGGGGACTTCAATAAAAATGAGTGGGAGGGCATGAGAAGGTTAAAAATCGTTGCTGAGTATGACCATAAAGCCATGG


GAAGCAGGCACAAAAGGGAGGGGAGGGAGGGAGTGTGAATATGTGAGTGAGTGTGAGTGTATGCACTTGTGTGAGTGTGTATGTGTA


TGAGTGTGTATGTATCTGAGTGTGAATGTGTGTGTACATGTGTGTGAGTGTGTGCTTGTGTTTGTGTGTATGTGTATAAGTGTGAAT


GTGTATGTGAATATGTGTGTGAGTGTGCAAGTGTGTATGAGAGTATGTATGAGTGTGTGAGTTTGTGTGAGTGTGTGTGTCTATGTG


TGTGAGTGTATATATGAGAGAGAGAGAGAGAGAGAGAGAGAAAGAGAGAGAGGGAGGGAGAGTTTGTGTTTTCCATCCCTCGTGGTT


GTGTTAGAGAACACTTTGAGCCAATCTGTGCTTCAACTAGGCAGAGTTTCCCCAAGGCTGGAGGGTTATCAAGGTTGTTATCTGCTC


TGGTTTTCTGGAGAAACTAGAGCCTCTTCTTGGAATGTTCTGGAGTCCCTAGCTAACCTCCCTCTCTACTTCCTCAAAGGCGATTGG


GGGCTTCTCCTAAACCAGACACCAATGGTCCTCAGAGACCCTTGGTGCTCATGCCTTTTTAAACACTTGTGCATTAATGAAACTGGG


AGTTTCATTTCCTTGGGGGTTCTGATTCAGCAGGTATCTGAACCCGAGTATCTGCCACTTCGATGAGGCAAGATAAACTTTGAAAGG


GAAGACAATTGCACAGATATGCCAGAATGTTTGGACCAGCTTTGCAAAGGCCTTGCATTCTATTTAATTCACTTGTGATACAAGTTG


TCTACTGGCTCTGAACACAGAGTTCCAGGAAAATTATCAGATTAAAATAAAGATAAACTCACAGGAATGATATGGTATCCAGGGATA


AGGCTGGTAATTAAAACACTGAGTGTCTTTAAATGGAATTTTCCATCTTGCAGTAGAAATTCTGTGGATCTTGTGCTGATCAAGGAC


TCTCATTAGCTAGTAATATATCTGCTTGACTTATAAAAAAAAAGATGAGAGCAGAACTAATTACTATCAAACAAATACAGTTTTAGA


CTAAAAAATAGTAAACTTTTAAAATACAAAGCCCCAAATTAGAGGCAGACACAGGGAACAGAGAAAGGAATCATAAAAATGTATGGG


AAAAAAATGGAGAAAACCAAAATGACCATACTTGAGTTCAACTTTAGCAAAGTTGTTTATTATTGGAAGGGATGTACAAATAGATGA


AGCTTTGCTGAGACACGGACAGCTCAGTCTCTGCCGCCTGCTACCCATTCTGCTATCAGGATGTATATATTTTAACTGGTGATTTAA


AAGCTCCCAGCAAGTCCAAGGGATGGATGCTGTGTCTTCTCCTTGATCCCATGACAATCAGCATTTCACTTTGCACAAGTTTCTAAG


TGGTTTTCATGTTTTAGAAGTCACATGGATTATGACTGGGAGCCAAAAACCTGTTCCATTTTCAGTTGTTGGCACCAAAATAATAAT


AATGTTAATAGACAAAACAATTTCAAGGACATCAGTGGACTCATCTTTGATTTAAGAAAAATCAGAGACATAAAAGTTGCTGTAAAG


AAAATGAAGAAAACAAAGCTTCCTGGAATCAAAGCAGGAGCCATAACAGTTTACAGGAACACAAGTAGTGACCAACCATCAAAGCAG


TGTCTGCGTGAGGTCAAGCAGGGACAGTCAGGGTCGATTGTACCACACTGGACGCCTCCTGTGCACTTCTGTTATTGACCATGCTTT


GTGCACAAAGAAACCAAGGCATTGAGAAATTGATTTGCCCAAGAGTGCACAGTTACCATCGGTCATAATGAAGACGACATGGTCTTC


ATCACTATAGCATGACAGGACATTTGTGCAACCATTTGCTGTTTTCTCTTTGTATGTGACATATCCACAATGATCTTCACATAGCCA


TGTGCTTCTCAGCTGAGGAAATGAAGCTTAGAAGACTGAGTTAGGATGTAGAAGGTAGTGGAAAGTGATCAAGGGTGTGGCTCATAG


GGACCTCTCCACTGTGCACTAGCTCTGTGAACTTGGCTAGGTCACACAGCTTTTGAGTGTCATTCTTCTCCTGTGTAAAGTTCAAAG


TTCTTTTGAAGATATACACATACACACACACTCACCTGGTTAGTATTATCATTTAAACAATTAAAACATTTTTTTGTGTTTATTTGT


GTGTGTGTGCCCATCTGAGTGTGCGTGTGTGCATGCATGAGTGTGTGTGTATGTGTGTGTGTGTGTATACATAAGTGCATCAAAGAA


TAATGTATGGGAGTCAGTTCTCCTTCCTCCATGTGGCTTCCAGGGATCGAAGCCATGTTGCCAAGTTTGGTAGCAAGTGTCTTTACT


CACAGAGTCATCTTGTTGGTTCCATTTAAACATTTTAAGCAGTACTGAAATTAAGTCTAATTCTAAAAACTTCCTTCTATCACTTTA


ATAGACCCAACTACTTAAATATTGATATTTTTGAGGAAAGAGAAACATGATTCCACGTGAAGGATGATCATAATACTTAGAATATAA


TTCTCACCCTTCAATTTCTTAGGTGGGTCCTCTCTGAGTTCTACGGCAGATTTCCACCTGGTCCTCACAGATGTGAATGACAACCCC


CCTCGCCTAGCTAAGGACTACACAGGCTTGTTCTTCTGCCATCCCCTCAGTGCCCCTGGGAGCCTCATCTTTGAGGTCACTGACGAT


GACCAGCAGTCACTTCGGAGGCCCAAGTTTACATTCGCCCTTGGCAGAGAAGGCTTACAAAGTGACTGGGAAGTTTCAAAAATCAAT


GGTGAGTTATCAAATGTACAATGAGAAAAATCAATGGTGGATGAAGGAATTACTTTGTGTGTGTATGTGCTAAAAACTTGAAGCATT


TTCACTAAAATCAGGAATAAACCAGGAGTGCCCCACCCTCCCTGACACCTGTTCAGTATAATAACTTGTAACATTAGATAAAAAATA


ACTCTGCAGCCAGTCCCACAGCACCCAGAGGAAGCTCCACTCACAGGCACTCTAACAATCCCAGGATCATAGGACCAGAGGTGAAGA


GGACACAACATCTACCCCAACATTGGAGGTAACTGGGACCAGCCGGACACAGGCATCCAGGAGCTCTGCCCACATGTGACACAGGTT


ACTTCCTCCCTGGGCTGGTGTCCTGAGCAGAATTTTGGTTCAAACTCCCCAGCCAGTTTCACAACACCCAGAGGAAGCTCCACTCCC


AAGGGCTCTGGCTCTCCCAGGATCATAGGATCAGAGGTGCCCTGAGCAGACCTTGGGTGTGAACTCCGGAGCCAGTACTACAACACC


CAGAAGTTTGACTCCCAGGCACTGTAACACCCCCAGGACCACAAGATCCCAGGATCCCAGGATCCTAGGAGCTTGATCACACTAGGA


TCTTAGGGTCCCAGAGGCAGCTTGACTCCCTGGAGCTCTGACGAACCTAGGATCTCAGGATAACAGGATCTCAGAATCACAGAGACA


GCTGAACTCTGAGGAGTTCTGACACAACAAGGATCACAAGAAGGACAGGATCCAGTCAGATATATGAGAGCAGATAGCACTAGAGAT


AATCAGATGGCAGGAGGTAAGCATAAGACAATAAGCAACAGAAACAAAGGTTACTTGGCATTATCAGAACCTAATTCTCCCACCATA


GCAAGTCTATACCATCACACCAGAAAAGCAAGATTCGGATCTAAAATCACTTCTCATGTTGGTGATAGAAGGGCATAAATAACTCCC


TTAAAGACATACAGAAGAACACAGGTAAACAACTAGAAGCCCTTAAAGAGGAAACCAAAAAAAAAAAAAATCTCTTGAATTCTAGGA


AAACACAATCAAACAGCAAAGGAAATGAACAAAACCATTGAAGATCTAAAAATGGAAATAGAAAACAATAAAGACATCACAAAGAGA


GACAACTCTGGAGTTAGAAAACCTAGGAAAGAGATCAGGAACCATAGATGCAAGCATCACCAACAGAATACAAGAGCTAGAAAAGAG


AATCTCAGGTGCAGAAGACACCATAGAAAACATTAACACAACAGTCAAAGAAAATACAAAAAGCAAAAAGCTCCTAACCCAAAACAT


CCAGGGAATCCAGGACACTATGAGAAGATGAAACCTAGGGATAAAAGGTATAGAAGAAGGTTTCCAACTTAAAGGGCCAGTAAATAT


CTTCAACAAAATTATAGATGAAAACTTCCCTAACCTAAAGAAAGAGATGCCCATGAACATACAAGAAATCTACAGGACTACAAATAG


ACTGGGCCAGAAAAAAAATTCCTCTCATCACATAATAATCAAAATACCAAATTCACTAAACAAAGAAAGAATATTAAAACAGTAAAG


GAAAAGGGTCAAGTAACATATAAAGGCAGACCTATTAGAATTACACCAGATTTCTCACCAGAGACTATAAAATCCAGAAGACCCTGG


GCAGATGTCATACAGACCCTAAGAGAACACAAATGCCAGCCCAGCCTACTATACCCAGCAAAACTCACATTACCATAGATGAAGAAC


CAAGATATTCTAATACAAAACCAAATTTACACAATATCTTCCCATAAATCCAGCTCTACAAAGGATAATAGATGGAAAACATCAACA


CAAGCAGGGAAACTACACCCTAGAAAAAGCAAAAAAGTACTCAACTTTCAAAAAACCTGAAAGAAGATAGCCACACAAACATAATTC


TACCTCTAACAACAAAAATAACAGAAAGTAACAATCACTTTTCCTTAATATCTCTTAACATCAATGGGCTCAATTCCCCAATAAAAA


GACATAGACCAACAGACTGGCTACATAAACAGGACCCATTTTGCTGCATACAGGAAACCCACCTCAGGAACAAAGACAGACACTACC


TAAGAGTAAAAGGTTGGAAAACAATTTTCTAAGCAAATGGTCCCAAGAAACAAGCTGGAGTAGCCATTCTAATACTGAATAAAATCA


ACTTTCAACCAAAAGTCATCAAAAAAGATGAGGAAGGACACTTCATACTGGTCAAAGGAAAAGTCTACCAAAATGAACTCTCAATTG


TGAACATGTATGCTCCAAATGCAAGGGCACCCACATTCATAAAAGAAACTTTACTACAGCTTAAACCACACATCTCACCCAACAATA


TAATAGTGAAAGACTTCAACACTCTCATCAATGGACAGATCATGGAAACAGAATCTAACCAGAGACACAGTGAAACTAAACAAAAGT


TATGAGCCAAAAGGATCTAACAGATATTTATAGAATATTCATCCTAAACCAAAAGAATATACCTTCTTCTCAGCACCTCTCAGTAAC


TTCTCCAAAACTGACCATATACTTGATCCTAAAACATGACATACAAGACATACAAGAACATTGAAATAATCCCATGCACCCTATTAG


ATTACCATAGACTAAGTCTGGTCTAGAATACCAACAAAAACGATGGAAAGCACACATACACATACAAGCTGAACAATGCTCTACTCA


ATGAAAACTTGGTCAAGGAAGAAATAAAGGAAGAAATTAAAGGCTTTTTAGAACTTAATGAAAATGAAGACACATCACACCAAAACT


TAGGGGACACAATGAAAGCAGTGGTAACAGGAAAACTCATAGCTCTGAGTGCCTCCAAAGAAAAACTGGAGAGAGCTTACCCCAGTA


GCTTGACAGCACACCTGAAAACTCCAGAACAAAAAGAAGCAAATATACCCAGGAGCAGTGGAAGGCAGAAAATAATCAAACTCAGGG


CTGAAATTAACCAAGTAGCAACAAAAAGAACTATATAAATAATCAACAAAAGCAGGAGTGGGTTCGTGGTGGCCCATGCCTTTATTC


CCAGCACTTGGGAGGCAGAGGCAGGCAGATTTCTGAGTTCGAGGCCAGCCTGGTCTACAGAGTGAGTTCCAGGACAGTCAGGGCTAC


ACAGAGAAACCTGTCTCAAAAAACAAAAAGAAAAAAAAAGAAAAAAAGAAACTCAACAAGATAGATAAACCCTTAGCCAAACTAACC


AGAGGGCACAGAGATAGTATCCAAATTAACAAAATCAGAAATAAGAAAGGAGACATAACAACTAAACATATCTTTAATTATTCTGTT


TGTTGAATATTAACATTTGAAAACATTAAAATCATGTTCTACACACATCATGGAAGTATTATTGACAATTTTTCGCACTGAGCTTGA


ATTAGCATTTTCTTAATGTGTAACTTCAAAGGGTTTTTGCTATTTTGAAATTTTTAAAATATACTTACTGATAAAATAATTTCTCTC


CTAGAGACACTGGTCTTTTCTAAGTAAACTTATAGTTAGACAATGTACACAGATATATAAAGCATTTTAAATACTCTCTCACTATGT


CAGGTGGTATCATATAAGGGCTTTTGAATGTATTTCTTGAGTCATTTTTAATATTTTGTGTTCTTTTATTGTGCTTAATTCCAATAT


TTTGTATGTTTTGAAACAATTTAGTATTCCACATTAGATATAGGATCCTCAATTATGGATAGAATCAAATATTCATTAACAATATTT


TTAGGGTATGAAAGGATATGAATATAAAAGTTGTACAATTTTTTATGTATTATTTGATTCTCAAAATACTCAATATTATTAATATGT


TTGATGTATAAAATGCATTTAAATAATAAATATTTAAGGGAAAAACTAAATAAACAAAAACAAAACAAGGAGATACAGGAGATAGCA


AATAGACAAGGAAGAAGTTAAAAGGATGTGTTAGCCCATTTTTTTTGGTAAGAGACATGGAAAAATATGTTAAATATGTTAAATTAT


TCAAACTATCACCTATATCAGACTATTTTTCAATTTACTTAATTATATACAATGCAAAAATGAGCTTTATTTCTGCTGAGTGAAGGT


TCTAGAGTTGTATTATCACGTGATTCATTTTCTCCCTGTTCTGACAGGTACACATGCTAGACTCTCCACCAGGCACACACGCTTTGA


GGAACAAGTTTATAACATTCCAATCCGCATCAATGATGGGGGGCAGCCACCCATGGAAGGGACTGTCTTCTTACCAGGTAGGTACCG


TGTAAAGGTGATGTAGGATATAGGGTACCATGTGCACTTTAAGAAATGCTTCTTTAAGTTGGGATTTTGCAACTATTCACTTAAAAA


CGTAATCTATGGAGCCCTGTTCTGCTTTTTAGTTACTTTCTGCCAGTGTGTGGAAGGAAGCTGTTTCCGGCCAGCAGGCAGACAGGA


TGGGATACCCACTGTGGGCATGGCAGTTGGTATACTTCTGACCACATTTCTGGTCATTGGTAAGTATGACTTTTCAGAGCCAAGGTT


TCCTGCCCCCAGCCTCAGATGTGAGCTCATCATGCCATCTATAGGGGTGCTCTGGGGGTTTCTTGCCTTGGGTATCAACCAAGAATA


CAAGTCCCCAGTCAATCACATCAAAGTATCCTGGTTGAGAAATACTGTGTCAAAGCTCCCATCTTCCTGTCATTTCCTTGCTTGGAT


TTTCATGCTGACATTTATACCAGAAGGCTCTTTATTAACCAGCCATTCTTTATTGTAGCAAATATCTAAGACAATCAACATTTTAAA


AAAGTTTCTATTTGGCTCATGGCTTCAGTAGTTTCAGAGGTCCACGATTGACTGGCCTGTTGCTTGGGGGTCCACAGGAAGATAGTA


CTTTATTGAGGAAAGCTGCTCACCTCCCTTTGGGAACAAATGAGAGAGGAAGCGGGAAGGGGCTCAGGTCCTACTGTTCCCTTGCAG


GGTACAGTCTTCAACTGTCTAGGGGAGGTCGTCTGTTGATAATGCTGAATTGGGAACATTTGAAGGCCATTTAAGATTGTAACCAAT


ATCAAACTTTACACACAAATTGCTGCATTTTGGGCCGAGTTACCAAGCTCTTATGAAGGAGAAACAAATTAGTCTCTGTGACCTGCT


GTGTCGGGCACTGAGTTTATTAGAACTGATATCATGATGGGCAAGGCCTGCATTGACCCTCTACCCGTGTTGGAATAGGGAGGGGTA


GGCTGTGAAATGAAGATTCTGTGACACCTGAGATGCTGCCGAGTTTCCCTTTGCGTTATTTTCATAACTCTGGCCTCTGCGTCTTTA


CAACCTGGAGTAATTTCACAGCATCATGGCTTTGACTCTTCCCCTAGCTGGAGAGCTGTCCTCTCTCATGCACGGAGAGCAGCTGGC


CTCCTTGAGAACGCTGTCTGCTGCATGTGAGCGGCCCTTCTTTTGAGAGGGACTTGCTTTGTAGTCCAGACTGGCCTTGAACTCAGG


CAAGCTCCCAGCCTCAGAGCTAGATTTTGAGATACTGTTTACTAAATCCTTTGGCCTTTATGCCTTTTATTGTTTTTCCTACCCACC


TTGAGAAGATTGAGTTCATGCGCCACACTGAAATTTTTTCACACAGCCTCATTCCCATGATCCTACTCTAAGTAAAGAATGGGCAGT


TTTGAGGATATATAGAAATAGAATTGACAGGGCTATTTTTGTTTTGTACCCTTATTCTTTTCGAATGGGGGCATGTGAATAATCACA


AGATTGTCAGCAAGTGTCTGAATGTCTAGTCTTCTTGGCTATGGTGCCTTCTGTAAGCTTATTGATGAGCAATTTCCTTATAGTAAC


TCTACACTTTTCCTAGTGGGCTCTGACAGTTGAGATTAGTGCTACAAAGCACAGCGTAGTCCTGTTAGAGTTCAGAGAAGTAAGAGA


AACCAGAATGAGTAGGCAGGCCACTGAAGGTCCCTCAGGAGAGGCTGGTACTGCGGGGAAGGTCCCCAAGCTGCGCATCTGACAACT


GCTCTACTAGTAAGCTGCATGCTGAGCCCTTACTGTGAAGTTAAAATTGTTTCAAAATCAATTTTAAATCATAAACAATTCATATTT


GGTAGATACAATGAAAGTAGACTCTAGGCAGGTGGGCAGGTCTAGATAACTCCCTAGTTATGATTAGACTTTTTTCTCTAGGGAAGA


AAAACTAGCATCAATGTTTGGGTATATACGTGGTTCAGACAGACTTATTTCCACATTCTTTTCCCTCCGAGGAATTATAGCACTGGC


TCCTCTATTCCCTATTGCCAGCCTCCAGGTTAGTTATAACTTCGGGCTTCCTATATACTCATAACAAATGACCTCTTTACTTATCCA


AGAGAGCCAATGCCCAGAGCTCTATACTCACTAGAACAACGAAGCACAGTTTAATCACACAAATGGTGGCTCACAAGTCATCCCCAC


TCCTACCCTATAAGTGACTGTGTTAGGACATCTGAAGACTGTGCTTGTTTGACCCTGAGTTTTCTCTTTTCAGGTATAATTTTAGCA


GTTGTCTTCATCCGCATGAGGAAAGATAAAGTTGAAAATCCGCAGTCCCCTGAGAATAAGCCTCTGAGAAGCTGAATTTGAAAAGAA


ATGGTCAAGTCTGTGCACCAAGCACTATATCAATGCCTCAGCTGTTTAATTTCATCCAAAATGTGAACTATAATTGGTAGAGTTTAT


GCATCATGGGCTATATCTGGTCCCCAGCTGTTTAATCTCATAATTTCATCCAAAATGTGAACTGTAATTTCTTTGATGGCATGCCCT


TCTTGTCCTGCAACATTTTATGCTACTTAGATATTTTATGTTCTGCAGACATTAGAGTTATTCTCCATTTCCCCATAACATTTTCCT


CCTTTACAAAAGCCTTAGCTTTATAACTTGAACCTTCCCCTCTGGGCAGGAAGAGGAGCTGAGTACACACCCTGTGTTGTTGCTTCA


GAGGACGTAGCTGTTATCTATCACCAAATTTCCTAGGTTCCACTTATCCTTTCTGTTTCAGCCTGTGCTCCTTCATCTCTTAGCATT


ACACTGAATTTAAAATGTGTCAAACAGAAGAACAAAGTGAAGTCCTGGTTGGGGGTTGGGGGGTAAGTGGGAGCCTTGTTCTTTAAC


ATGGGCAACAGCTTCTCTGTGCTGTTAATGTTGTTAATGGCGGTCCTCCAACTTGGCTATGGCACAGACGCTGATGAGGTTATCAAA


TTCAACTGCTCTATTTCAAGAAAGATCTACTTCCTACGGCACAGGAACTGGTGAGCTGTCTGGTTTACTCACTACCACATGCTTTCA


TACCTGCTGTACACGTTTTATTTGTATATTGAAGTTTTGTTATATATTTATCATGTGGAGGAAACAAGAAAGTATAAAGTGGTAAAG


AAATC





MOUSE mRNA SEQUENCE: mR28-010.1 (Seq ID No: 56)


AGGGAGAGGCTAGAGGAGCAGAACAGGTTGAGGAAGTGTCTCTTAGGGTTCTTCAGCCACAGCAAGTGTCTCCACGGCTGAATGGAC


GACAAAACTTCTAAGCAGCATTTCTTACTTACTGAAAGGAGTCCAAGTGAAGAGAGCAAGATGGTGTCTGCCCAGCTTCAACTTCCT


GTGTCTTCTCACACTTTATTTGACCTGTGGATATGGCGAAGAAGGGAAGTTCAGCGGTCCCCTGAAGCCCATGACATTCTCCATTTT


TGAAGGCCAAGAACCGAGTCAAGTCATATTCCAGTTTAAGACCAACCCTCCAGCTGTGACTTTCGAGCTAACGGGAGAGACAGAAGG


TATATTTAAGATAGAAAAGGATGGACTTCTGTATCACACAAGAGCCCTGGACAGAGAAACAAGAGCGGTTCATCATCTGCAGCTTGC


AGCCTTGGATTCTCATGGAGCTATAGTGGACGGTCCAGTCCCCATCACCATAGAAGTCAAGGACATCAATGACAACCGACCCACGTT


TCTCCAGTCAAAATATGAAGGCTCAGTGAGGCAGAACTCTCGCCCAGGAAAGCCTTTCATGTATGTCAATGCTACAGATCTGGATGA


TCCGGCTACTCCCAATGGCCAGCTTTTTTATCAAATTGTCATCCAACTTCCCCAAATCAACGATGTTATGTACTTTCAAATCGACAG


CAAAACAGGGGCAATATCGCTTACCCCAGAAGGATCCCAGGAATTGGATCCAGTGAAGAATCCTTCCTACAACCTGGTGGTCTCGGT


GAAGGACATGGGGGGCCAGAGTGAGAATTCCTTCAGTGATACTACATATGTAGATATTTCTATTAGAGAGAATATCTGGAAAGCACC


AGAACCCGTGGAGATTAGAGAAAACTCGACTGATCCTCACCCCATCAAAATCACTCAGGTGCAGTGCAATGACCCAGGGGCCCAGTA


TTCCTTAGTCAACAAGGAGAAGCTGTCGCCGTTCCCATTCTCGATCGACCAAGAAGGAAATATTTATGTGACTCAGGCCTTGGACCG


GGAGGAAAAGAACTCACATGTTTTCTTTGCAACTGCCAAGGATGAGAATGGAAAACCACTTGCATATCCACTGGAAATTTATGTGAA


AGTTATTGACATTAATGACAACCCACCGACATGTCTGTCTCCAGTGACTGTATTTGAAGTCCAGGAGAATGAACCATTGGGTAACAG


CATCGGGATCTTTGAGGCCCATGATATGGACGAAGCTAACAACATCAACAGTATTTTGAAATACAAGCTTGTAGACCAAACACCCAA


AGTTCCCTCAGATGGACTTTTTCTCATTGGTGAATATGAGGGAAAGGTTCAGTTAAGTAAACAGTCCTTGAAGAAGCAAGACAGTCC


TCAGTACAACTTAAGTATCGAGGTGTCTGACGTAGATTTCAAGACTCTCTGTTATATTCAAGTCAACGTTATTGATATCAATGATCA


GATTCCCATCTTTGAAACATCAAATTATGGAAGCAAGACTCTGTCTGAAGACACCGCCATCGGATCCACCATCCTAATCATCCAAGC


TACAGATGCTGATGAGCCCTTTACAGGGAGCTCTAAAATCCTGTACAAGATTGTACAGGGAGACACGGAGGGAAGACTAGAAGTTGT


CACAGATCCCACGACCAATGCAGGATATGTCAAGATCAAAAAGCCTCTTGATTTTGAAACTCAACCAGTTAGCAGCATTGTGTTCCA


AGCGGAAAATCCTGAGCCACTGGTGAAAGGCATAGAGTACAATGCTAGTTCTTTTGCCTCCTTCGAGCTGATTGTGACGGATGTGAA


TGAAGTGCCTGTGTTCCCCCAGCGAATATTCCAAGCAAACGTCAGCGAGGATGCTGCTGTGGGCAGTAGAGTGGGCAACGTGACTGC


CAGGGATCCTGAAGGCCTGACTGTGAGTTATTCACTGAAAGGCAATATGAGAGGCTGGCTTAAAATCGACTCTGTCACTGGTGAGAT


ATTTAGTGCTGCTCCGCTGGATAGGGAAACAGAAAGTGTGTATCGAGTACAAGTGGTGGCCACTGAAGTAGGTGGGTCCTCTCTGAG


TTCTACGGCAGATTTCCACCTGGTCCTCACAGATGTGAATGACAACCCCCCTCGCCTAGCTAAGGACTACACAGGCTTGTTCTTCTG


CCATCCCCTCAGTGCCCCTGGGAGCCTCATCTTTGAGGTCACTGACGATGACCAGCAGTCACTTCGGAGGCCCAAGTTTACATTCGC


CCTTGGCAGAGAAGGCTTACAAAGTGACTGGGAAGTTTCAAAAATCAATGGTGAGTTATCAAATGTACAATGAGAAAAATCAATGGT


GGATGAAGGAATTACTTTGTGTGTGTATGTGCTAAAAACTTGAAGCATTTTCACTAAAATCAGGAATAAACCAGGAGTGCCCCACCC


TCCCTGACACCTGTTCAGTATAATAACTTGTAACATTAGATAAAAAATAACTCTGCAGCCAGTCCCACAGCACCCAGAGGAACCTCC


ACTCACAGGCACTCTAACAATCCCAGGATCATAGGACCAGAGGTGAAGAGGACACAACATCTACCCCAACATTGGAGGTAACTGGGA


CCAGCCGGACACAGGCATCCAGGAGCTCTGCCCACATGTGACACAGGTTACTTCCTCCCTGGGCTGGTGTCCTGAGCAGAATTTTGG


TTCAAACTCCCCAGCCAGTTTCACAACACCCAGAGGAAGCTCCACTCCCAAGGGCTCTGGCTCTCCCAGGATCATAGGATCAGAGGT


GCCCTGAGCAGACCTTGGGTGTGAACTCCGGAGCCAGTACTACAACACCCAGAAGTTTGACTCCCAGGCACTGTAACACCCCCAGGA


CCACAAGATCCCAGGATCCCAGGATCCTAGGAGCTTGATCACACTAGGATCTTAGGGTCCCAGAGGCAGCTTGACTCCCTGGAGCTC


TGACGAACCTAGGATCTCAGGATAACAGGATCTCAGAATCACAGAGACAGCTGAACTCTGAGGAGTTCTGACACAACAAGGATCACA


AGAAGGACAGGATCCAGTCAGATATATGAGAGCAGATAGCACTAGAGATAATCAGATGGCAGGAGGTAAGCATAAGACAATAAGCAA


CAGAAACAAAGGTTACTTGGCATTATCAGAACCTAATTCTCCCACCATAGCAAGTCTATACCATCACACCAGAAAAGCAAGATTCGG


ATCTAAAATCACTTCTCATGTTGGTGATAGAAGGGCATAAATAACTCCCTTAAAGACATACAGAAGAACACAGGTAAACAACTAGAA


GCCCTTAAAGAGGAAACC





MOUSE PROTEIN SEQUENCE: mP28-010.1 (Seq ID No: 57)


MVSAQLHFLCLLTLYLTCGYGEEGKFSGPLKPMTFSIFEGQEPSQVIFQFKTNPPAVTFELTGETDGIFKIEKDGLLYHTRALDRET


RAVHHLQLAALDSHGAIVDGPVPITIEVKDINDNRPTFLQSKYEGSVRQNSRPGKPFMYVNATDLDDPATPNGQLFYQIVIQLPQIN


DVMYFQIDSKTGAISLTPEGSQELDPVKNPSYNLVVSVKDMGGQSENSFSDTTXTDISIRENIWKAPEPVEIRENSTDPHPIKITQV


QWNDPGAQYSLVNKEKLSPFPFSIDQEGNIYVTQALDREEKNSHVFFATAKDENGKPLAYPLEIYVKVIDINONPPTCLSPVTVFEV


QENEPLONSIGIFEAHDMDEANNINSILKYKLVDQTPKVPSDGLFLIGEYEGKVQLSKQSLKKQDSPQYNLSIEVSDVDFKTLCYIQ


VNVIOINDQIPIFETSNYGSKTLSEDTAIGSTILIIQATDADEPFTGSSKILYKIVQGDTEGRLEVVTDPTTNAGYVKIKKPLDFET


QPVSSIVFQAENPEPLVKGIEYNASSFASFELIVTDVNEVPVFPQRIFQANVSEDAAVGSRVGNVTARDPEGLTVSYSLKGNMRGWL


KIDSVTGEIFSAAPLDRETESVYRVQVVATEVGGSSLSSTADFHLVLTDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEVTDDDQQS


LRRPKFTFALGREGLQSDWEVSKINGELSNVQ*





MOUSE PANTHER CLASSIFICATIONS


FAMILY (SUBFAMILY)


CADHERIN (LIVER-INTESTINE-CADHERIN)





BIOLOGICAL PROCESS


Signal transduction(2.11.00.00.00) > Cell communication(2.11.03.00.00) >


Cell adhesion-mediated signaling(2.11.03.01.00)


Cell adhesion(2.29.00.00.00)





MOLECULAR FUNCTIONS


Cell adhesion molecule(1.05.00.00.00) > Cadherin(1.05.02.00.00)





MOUSE GENE ONTOLOGY


BIOLOGICAL PROCESS


cell adhesion > homophilic cell adhesion





MOLECULAR FUNCTION


ligand binding or carrier > calcium binding


cell adhesion > calcium-dependent cell adhesion





CELL COMPONENT


cell > membrane fraction





MOUSE PROTEIN DOMAINS (INTERPRO SIGNATURES)


IPR002126 (CADHERIN)


IPR002126 (CA)


IPR002126 (cadherin)


IPR002126 (CADHERIN 2 5)





MOUSE mRNA SEQUENCE: mR28-010.2 (Seq ID No: 58)


AGGGAGAGGCTAGAGGAGCAGAACAGGTTGAGGAAGTGTCTCTTAGGGTTCTTCAGCCACAGCAAGTGTCTCCACGGCTGAATGGAC


GACAAAAACTTCTAAGCAGCATTTCTTACTTACTGAAAGGAGTCCAAGTGAAGAGAGCAAGATGGTGTCTGCCCAGCTTCACTTCCT


GTGTCTTCTCACACTTTATTTGACCTGTGGATATGGCGAAGAAGGGAAGTTCAGCGGTCCCCTGAAGCCCATGACATTCTCCATTTT


TGARGGCCARGAACCGAGTCAAGTCATATTCCAGTTTAAGACCAACCCTCCAGCTGTGACTTTCGAGCTARCGGGAGAGACAGATGG


TATATTTAAGATAGAAAAGGATGGACTTCTGTATCACACAAGAGCCCTGGACAGAGAAACAAGAGCGGTTCATCATCTGCAGCTTGC


AGCCTTGGATTCTCATGGAGCTATAGTGGACGGTCCAGTCCCCATCACCATAGAAGTCAAGGACATCAATGACAACCGACCCACGTT


TCTCCAGTCAAAATATGAAGGCTCAGTGAGGCAGAACTCTCGCCCAGGAAAGCCTTTCATGTATGTCAATGCTACAGATCTGGATGA


TCCGGCTACTCCCAATGGCCAGCTTTTTTATCAAATTGTCATCCAACTTCCCCAAATCAACGATGTTATGTACTTTCAAATCGACAG


CAAAACAGGGGCAATATCGCTTACCCCAGAAGGATCCCAGGAATTGGATCCAGTGAAGAATCCTTCCTACAACCTGGTGGTCTCGGT


GAAGGACATGGGGGGCCAGAGTGAGAATTCCTTCAGTGATACTACATATGTAGATATTTCTATTAGAGAGAATATCTGGAAAGCACC


AGAACCCGTGGAGATTAGAGAAAACTCGACTGATCCTCACCCCATCAAAATCACTCAGGTGCAGTGGAATGACCCAGGGGCCCAGTA


TTCCTTAGTCAACAAGGAGAAGCTGTCGCCGTTCCCATTCTCGATCGACCAAGAAGGAAATATTTATGTGACTCAGGCCTTGGACCG


GGAGGAAAAGAACTCACATGTTTTCTTTGCAACTGCCAAGGATGAGAATGGAAAACCACTTGCATATCCACTGGAAATTTATGTGAA


AGTTATTGACATTAATGACAACCCACCGACATGTCTGTCTCCAGTGACTGTATTTGAAGTCCAGGAGAATGAACCATTGGGTAACAG


CATCGGGATCTTTGAGGCCCATGATATGGACGAAGCTAACAACATCAACAGTATTTTGAAATACAAGCTTGTAGACCAAACACCCAA


AGTTCCCTCAGATGGACTTTTTCTCATTGGTGAATATGAGGGAGGTTCAGTTAAGTAAACAGTCCTTGAAGAAGCAAGACAAAGTCC


TCAGTACAACTTAAGTATCGAGGTGTCTGACGTAGATTTCAAGACTCTCTGTTATATTCAAGTCAACGTTATTGATATCAATGATCA


GATTCCCATCTTTGAAACATCAAATTATGGAAGCAAGACTCTGTCTGAAGACACCGCCATCGGATCCACCATCCTAATCATCCAAGC


TACAGATGCTGATGAGCCCTTTACAGGGAGCTCTAAAATCCTGTACAAGATTGTACAGGGAGACACGGAGGGAAGACTAGAAGTTGT


CACAGATCCCACGACCAATGCAGGATATGTCAAGATCAAAAAGCCTCTTGATTTTGAAACTCAACCAGTTAGCAGCATTGTGTTCCA


AGCGGAAAATCCTGAGCCACTGGTGAAAGGCATAGAGTACAATGCTAGTTCTTTTGCCTCCTTCGAGCTGATTGTGACGGATGTGAA


TGAAGTGCCTGTGTTCCCCCAGCGAATATTCCAAGCAAACGTCAGCGAGGATGCTGCTGTGGGCAGTAGAGTGGGCAACGTGACTGC


CAGGGATCCTGAAGGCCTGACTGTGAGTTATTCACTGAAAGGCAATATGAGAGGCTGGCTTAAAATCGACTCTGTCACTGGTGAGAT


ATTTAGTGCTGCTCCGCTGGATAGGGAAACAGAAAGTGTGTATCGAGTACAAGTGGTGGCCACTGAAGTAGGTGGGTCCTCTCTGAG


TTCTACGGCAGATTTCCACCTGGTCCTCACAGATGTGAATGACAACCCCCCTCGCCTAGCTAAGGACTACACAGGCTTGTTCTTCTG


CCATCCCCTCAGTGCCCCTGGGAGCCTCATCTTTGAGGTCACTGACGATGACCAGCAGTCACTTCGGAGGCCCAAGTTTACATTCGC


CCTTGGCAGAGAAGGCTTACAAAGTGACTGGGAAGTTTCAAAAATCAATGGTACACATGCTAGACTCTCCACCAGGCACACACGCTT


TGAGGAACAAGTTTATAACATTCCAATCCGCATCAATGATGGGGGGCAGCCACCCATGGAAGGGACTGTCTTCTTACCAGTTACTTT


CTGCCAGTGTGTGGAAGGAAGCTGTTTCCGGCCAGCAGGCAGACAGGATGGGATACCCACTGTGGGCATGGCAGTTGGTATACTTCT


GACCACATTTCTGGTCATTGGTATAATTTTAGCAGTTGTCTTCATCCGCATGAGGAAAGATAAAGTTGAAAATCCGCAGTCCCCTGA


GAATAAGCCTCTGAGAAGCTGAATTTGAAAAGAAATGGTCAAGTCTGTGCACCAAGCACTATATCAATGCCTCAGCTGTTTAATTTC


ATCCAARATGTGAACTATAATTGGTAGAGTTTATGCATCATGGGCTATATCTGGTCCCCAGCTGTTTAATCTCATAATTTCATCCAA


AATGTGAACTGTAATTTCTTTGATGGCATGCCCTTCTTGTCCTGCARCATTTTATGCTACTTAGATATTTTATGTTCTGCAGACATT


AGAGTTATTCTCCATTTCCCCATAACATTTTCCTCCTTTACAAAAGCCTTAGCTTTATAACTTGAACCTTCCCCTCTGGGCAGGAAG


AGGAGCTGAGTACACACCCTGTGTTGTTGCTTCAGAGGACGTAGCTGTTATCTATCACCAAATTTCCTAGGTTCCACTTATCCTTTC


TGTTTCAGCCTGTGCTCCTTCATCTCTTAGCATTACACTGAATTTAAAATGTGTCAAACAGAAGAACAAAGTGAAGTCCTGGTTGGG


GGTTGGGGGGTAAGTGGGAGCCTTGTTCTTTAACATGGGCAACAGCTTCTCTGTGCTGTTAATGTTGTTAATGGCGGTCCTCCAACT


TGGCTATGGCACAGACGCTGATGAGGTTATCAAATTCAACTGCTCTATTTCAAGAAAGATCTACTTCCTACGGCACAGGAACTGGTG


AGCTGTCTGGTTTACTCACTACCACATGCTTTCATACCTGCTGTACACGTTTTATTTGTATATTGAAGTTTTGTTATATATTTATCA


TGTGGAGGAAACAAGAAAGTATAAAGTGGTAAAGAAATCGGAAAAAAAATGTTGGTTTCAATT





MOUSE PROTEIN SEQUENCE: mP28-010.2 (Seq ID No: 59)


MVSAQLHFLCLLTLYLTCGYGEEGKFSGPLKPMTFSIFEGQEPSQVIFQFKTNPPAVTFELTGETDGIFKIEKDGLLYHTRALDRET


RAVHHLQLAALDSHGAIVDGPVPITIEVKDINDNRPTFLQSKYEGSVRQNSRPGKPFMYVNATDLDDPATPNGQLFYQIVIQLPQIN


DVMYFQIDSKTGAISLTPEGSQELDPVKNPSYNLVVSVKDMGGQSENSFSDTTYVDISIRENIWKAPEPVEIRENSTDPHPIKITQV


QWNDPGAQYSLVNKEKLSPFPFSIDQEGNIYVTQALDREEKNSHVFFATAKDENGKPLAYPLEIYVKVIDINDNPPTCLSPVTVFEV


QENEPLGNSIGIFEAHDMDEANNINSILKYKLVDQTPKVPSDGLFLIGEYEGKVQLSKQSLKKQDSPQYNLSIEVSDVDFKTLCYIQ


VNVIDINDQIPIFETSNYGSKTLSEDTAIGSTILIIQATDADEPFTGSSKILYKIVQGDTEGRLEVVTDPTTNAGYVKIKKPLDFET


QPVSSIVFQAENPEPLVKGIEYNASSFASFELIVTDVNEVPVFPQRIFQANVSEDAAVGSRVGNVTARDPEGLTVSYSLKGNMRGWL


KIDSVTGEIFSAAPLDRETESVYRVQVVATEVGGSSLSSTADFHLVLTDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEVTDDDQQS


LRRPKFTFALGREGLQSDWEVSKINGTHARLSTRHTRFEEQVYNIPIRINDGGQPPMEGTVFLPVTFCQCVEGSCFRPAGRQDGIPT


VGMAVGILLTTFLVIGIILAVVFIRMRKDKVENPQSPENKPLRS*





MOUSE PANTHER CLASSIFICATIONS


FAMILY (SUBFAMILY)


CADHERIN (LIVER-INTESTINE-CADHERIN)


BIOLOGICAL PROCESS


Signal transduction(2.11.00.00.00) > Cell communication(2.11.03.00.00) >


Cell adhesion-mediated signaling(2.11.03.01.00)


Cell adhesion(2.29.00.00.00)


MOLECULAR FUNCTIONS


Cell adhesion molecule(1.05.00.00.00) > Cadherin(1.05.02.00.00)





MOUSE GENE ONTOLOGY


BIOLOGICAL PROCESS


cell adhesion > homophilic cell adhesion





MOLECULAR FUNCTION


ligand binding or carrier > calcium binding


cell adhesion > calcium-dependent cell adhesion





CELL COMPONENT


cell > membrane fraction





MOUSE PROTEIN DOMAINS (INTERPRO SIGNATURES)


IPR002126 (CADHERIN)


IPR002126 (CA)


IPR002126 (cadherin)


IPR002126 (CADHERIN 2 5)





HUMAN GENOMIC SEQUENCE: hD28-010 (Seq ID No: 60)


GGAAGAGGGAGTGTTCCCGGGGGAGATACTCCAGTCGTAGCAAGAGTCTCGACCACTGAATGGAAGAAAAGGACTTTTAACCACCAT


TTTGTGACTTACAGAAAGGTAAGGGCTGACATGTCTTAACTGTGTCAGTAACGTATTTATTCCAGAAGGACAAAGTAGATGGAGGGG


GAGGGCACTTAAAAAGTTGCTTGACAAATTTGTTCCTTGAGGTGGGCTATGCAGATGCGGAGAAGGGAAATTTGTTGCTGGCATGAC


AAGTTTTGCTTATGGAGCACAATTTTTTTTTGTAGTTTCTTTTCATTGGTCCATATTTTATAAATTCATTTGATGAAGTGGCTGCAG


TGAAATCAAGCTTGGCAGTGGAATTAAAGGGGAAATTGAGTTCTCTGATGTTTAAACAAGTATCACATCCATTCTTTGTGATGAGTA


TATAAAAGTCCCTGGTCTTAAGATGCTCTAGGGCTCTTGTATTCTAGAAATTGGGGTTGGAATCACATTCTCAAAAAGCATGTCATT


CTATCTACTTCTCAGAGAATGAGATTCAATTTGGGATTCTTAGAATTGTCTAGGACACAGCAAGGGAGGGAACATGCAGAGAAGAAG


AAAAGTCTTTTTGTAAAAGTACTAGAATAAGAATTGAAGACAGACAGACCTGCCTTCACAAGTGAGAGAAGAGGCTGATGTGCGTGT


TAATCAGCTTCCTGGGCTGCTTTTGGCCTTGGTGGTGGAGTTACCACCTGCTAATGTGTGGTTATTTTTATGTTAAGCCACACACAG


CTTATTGGTATCTTCAATGGTCCGATATTTGCCTCTGTCTTGGTCTTTTATGACAGGTGACTTTATAGGGACAGATGCCCTCTGTGG


TAGGGGATGCCAAGCAGCAGATTGGAAGGACAGTGCCTTCTCTAATATTTTCTTGTCTTTATTTTTCTTCAAAAGCTTAAATAGCAA


ATGAGGCATTATTTGAAAGAAGAAGAAAAAACACATGTTTAGATGAAAGGAAGATGAATGCTATTCAGCTCTCACCAGGAAACAAAG


CGAGTCCTTTACTGAGAGAGGGTTTCTAGTGAGTTACGGGGCCATATGAGTCTTCAGGGTTGGCCAAATGGGTTAGGCCAGTTTCAT


CATTTTCCAACCTGTGGGCACAGAACAGAGAGCTGCCACTAGAGACTTGCCTAACTAGGTAGTTGTGAGAAGTAAATTAGATAAGTA


GGTAAAGAGCTTACTATGTTGCTTGGTGCATGGTACACATCCAGTGAATGTTAGCGCTCTGTTCCATGAGAAAGTTCAAGTAGGTGA


CTCAGGATGAATTGAGAAATTTTTGTTTCATTCTTTAGAAAAATAAGAAAAAAATCAGTGATGCCATAAAAATAGCATCTACCATTA


TGCAAGAGAGGAACTAATTCTATGTTCAGGAAGTAGGATTCAAAAATATGAGAATAATAAAACTATTGGTTTTGCTATATATATAGC


ATTTTAAAGCCCCTCTCATGGTTCCCATATAAGTCTTTGGGTGAGGTGCAGGTGGGGCATCCTTTGAAACTCACCCAGATGACCCCT


GAAAAAAGTCATCACTGTTCAAGGTGAAGGTTACATTTCCGGTACCTCCTCCTTTCTCATACAAAAGGCAAAATATGGCTGGGTGTG


GTGGGTCATTCCTGTAATTCCAGTACTTTGAGAAGCTGAGGAGGGAGAACCGCTTGTGCTGGAGTTCAAGACCAGCCTGGAAGGTCT


GAACATAGGGAGATCCAGACTGTACAAGAAAATTAAAAATTAGCCAGGCATGATGGCACTTACCTATAGTCCTAGCGACTTGGGAGG


CTGAGGTGAGAGGATTCCTTAAGCCCAGGAGGTTGAGGCTGCAGTGAGTCATGATTGTGCCACTGCATTCCAGCCTGGGTGACAGAG


TGAGAACCTGTCTTCTAAAAAAAAAAAAAAAAAAAAAGGATGATGTGCAAAATATATCCTGGCAGAAACTCTACTTCTCGTTCCATT


GTCAAAAAAAATGTCTAGAAGGATGTGTCCCTCATTTTTCTTCCACATTAACAGCAACAGCTCTGAGGAGGAAAGCTGGGCATTGTC


ATGCTCCTTGCTCTGGAGGCCGACAAACAGTGCTTGAACAGAAGCTGGTTCACATGGGTAGAGATGTATAGATTTGACATAAAATTG


CATTGATTCAGAAATCTCTGGTATCAGATTTAGAATGGGGCTAGTTGTTCTGTAACTGCTCGTTGATTATCCAAAGAAAGACACACG


GAATTTTAAGGGAATACCTATCTACTTATTTGTTACTTGTAAGAACAGACAGGAAGAAGAAGGAATGTTTACTTAGGTACAAGAAAT


ATTAACTTAATAAAAGCAGATATTCCCCTAGTGGCTGAGGTATTAACTACACTAAAGTTGATTTTTTTTTTTCACTTAAGCAATACG


TAACAAGCTAAGCTATGCTTGATTTTTGTGTATGTGGTACAAAGAAAATTTCTCTTCAAATATTCTGTAAGACTGACATGGAATTCT


CTCATTCATGATATTTCTGAGTTATTCATTTTTGACCATATACTTATTACTTAAAAATATTAGGACTTGTTCTTAAGTGACGGATGA


GGAGAATGGAAATGGTAGATTTGTTCCCTTAACATCTAAGCTAAAGATGAGTTCTCTTCCTCACCAAGAGGCCATCTAGCAGAGTGG


CTTGGTGCTTGGCCCCTGCATTCACACCACTTCCTCAAGCGCTCTAAGCATCAGTTTCCTGCTCTGTGGGATAACAACAGGACCCAC


ATTATATGATTGTGTTGTTCAAGTAAGTTGTCCAAAGTGTTTAACTTAGCTTGCATTTGTTGAGCATTTGCTATTTTTTAAAACAAT


TCCAATGATTAAAAAAAAAAACAATTCATGAATGAGATTTCATCGTGGTCTGGCACCTTTTATTAAGCAGAATTAAATTTATTTTCC


CTTCCTCTCCTACCCATCCCAGTTGTCAGTTACGATTTAATTACAGAAATTGGAAAGTGAACCTGCCATACTTAAGCATGACTGCAC


ATTCTTGGCATTAAAATTCCTGCCTTGGGTCACTTTGCAAATGAACTGGTATTAGAGTATTTTTCTTTCTCTTCTCTTCTCTTTTCT


TTCTTTCTTTCGATCCTTCAGTGTCTAAATCCTATGGGATGGAACCTAATTTAGATTTACTTCCTACTCAATTTCTAAGGCCAGGAT


GTGTTGCTTTATTATCTTGACAAAATGCTCATCCGTAAACTTTATATTACATAAAGAAATGTTGTGTAATACATAAAGAAACACTTT


GTCAAAAAAAAGTCAAGCCACCCTTTATGAGAAATAGTGATTCCAGTCCTCCTCTTTAGTCCAGGGAAGATGCTTGTGATATTGTTC


TGCTAGATCTGGGGGAGAAAGGGTCTCCCCCTGCCACCTTCTAGGGTTTTTGCGGGTATATAGCTGCACACGTGAGGGAAGTCAATG


CTGAAATTCTTCCTGGCTACCTGCTTAAAACCCATTTATGCCTAGTGTTCCATTATTGGAACACTAAGCATGTGGGAGTTATTTATA


TCCTTCTGCACAAGGTCATCGTCAAGGTCTGATTGCAAAAATTCAAAAAATTGCAACCTCAGGTATAAATGGGTTACAACATCAGGC


AAGTGCCCTGGTGGGACAGTCACTGTTGTCCCTAGGTCAGTGGCTCCCTTTCCTGTGACTGCTCTGGCCCCCCTTCCATTCAATGCT


GGGATGTTTTGGGAGACTTGGAGGAGAGGCCTCTTCTCCCCAGCTGATCCTTCCCTTGCTCTGTCTTGGGGAGCACTGGGGGAACAA


ACGCCAACCAGGAACAACATGACACCTCTCTCAAATATTTCTTGGAACTTGTTATTCTTTTCTTTAATAAGAATAATTATGCTAGTA


ATCCCATTACTGGGTATATACCCAAAGGATTATAAATCATTCTACTATAAAGACACATGTACACGTGTGTTTATTGCAGCACTATTT


ACAATAGCAAAGACTTGGAGCCAACCAAAATGCCCATCAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATAC


TATGCAGCCATAAAAAAGAATGATTTCATGTCCTTTTCAGGGACATGGATGAAGCTGGGAACCATCATTCTCAGCAAACTAACACAG


GAACAGAAAACCAAACTCTGCATGTTCTCACTCATAAGGGGGAGTTAACAATGAGAACACATGACACAGGGGAACATCACACATCGG


GGCCTGTCCTGGGGTGGGAGGCAAGCGGAGGGAGAGTATTAGGACAAATCCCTAATGCATGTGGGGCTAAAACCTAAATGACGGGTT


GATGGGTGCAGCAAACCACCATGGCACGTCTATACCTATATAACAAACCTGCATGTTCTGCACATGTATCCCAGAACTTAAAGTAAA


ATTTTTAAAAAAAGAAAAAGTGAGACAAACATTTTTTAAAAAAAGAATAATTATGCTAGTAATGTGTATTATAATTGATTATATCAA


TCTAAACCATTTTAAGTTCTCCAGGGGACCATTTAGCCTCCCGTGAGCCCATCTTCCCTATCATGAACCTATTGGTAGAACAAATCA


TCACCTCTAATTTTGCATGTGTGTAAATCCAGATTTTCATATACTGAAAGATTGGCATATCTATATTACAGAGTTTAGTGACAGAAA


GCTGGGCTTATGTTTATGTATGTATGTTCATCCCTCCCTCCCTCCTTTCCTTCCTTCTTCCCTGTCTTCCTCTCTGCTCTAAAAACA


AATCATCCAGCTGCCCATTCCCTCCCCATGTGGAGTAATCTGTTTGAAGTGTGAGGCAGAAGCCCAGATTTATACCTGTCTGCTTGT


TTCTAGCTTATTAATGGCCACTTTAATTGGGTCCTTAATTTGTCAAAAGTGCAAATTGGTCAGATGCTTCTGCGGTTCTCTAAACCT


TGAGTGATCCAATTGGTGCCAGAGATCTGTGAGCCAGACCAAAAAGATGGGCGTGGCAGATCTGAACATTAATCGATGAAAAATGGT


TTGGGCGAGATTTTCATCTGATCTTTATATCTATCTGGCCTTGCCTTATAATTTATGCCGCTCTTAGCAATATACAGTGAGGAGGAA


AAATAAATGGCTCACAGGATATTTGGCACTGTTTGGTCCTGGTGGTGTTATGAATTCCAGTCACATCCCTTCCTGCCCACACTACCT


TAGGATATTTGAAAACAAATTCTGTAGCTCTCTCCTTCTGCAACTTCTTTGTTCTTTGAAGCTTCATGGCTCAGCCTTAGTGCTAGG


TGAATTATTTTAATTCAAAGCCCTTCATGCTTTTTAAAAAATAAATAAATAAGAGATGACTGACTCTAAGATTTGTCTATCACTTAG


CTTTTTTCACGGGGGACAAAAATCAATGCTTATGTGTTGACTTGTAAATCTGGAGATCTGGGACGTAGAAACTCCTTGTCCTTACTC


AAATAAATGGGTAAATGACAAGAGCGTCTAAACATCACCTTCCCATCTTGCAAGATGGTGGGTGAAAAAGTTGAGAAGCCGGATACT


AAGGAGAAGAAACCTGAAGCTAACAAGGCTTTGCCAGTGGCAAGGTGAAAAGGGGAACCTCAGAGCTAAAAAGCCCAAGAAGGGGAA


GCCCAAAATCCTGTCCTCATTGGAGGAATTGGCAGATATTCCTGATCTGCTATGTATTCCAGAAAGGCCATGTACGAGAGGAGGTAC


TTAGCTGCTAAACCCAAGATTGAAAAGAATCTCGCAACCGTTACAAACCCAGTTGAGGTGACAAGAATGGTGATGCCTGGCTATTTA


AACTTCACAAAATGCCTTGATATTATCCAACAGAGATGTGCCTCAAAAGCTGTCCAGCCATCGCAAGAAACTCTGCAGTCAGCATGT


GAGAAAACTTGGAGCCAGCACGGCCCTCGAGACCATTCTGCTCATCCTCCCTTGGTGCCACCAAGGCAGGAGGGTGGTTTTCCTGGA


GCAGCTGGGCAGTAGCTTGTTACTTGTGGCTGGACCTCTGGTCTTCCATGGAGTTCCTCTGTGAAGGACACACCAGAAATTTGTCAT


CACCACCTCCATAAAAATTGATATCAGGACTGGGTGCAGTGGCTCACACCTATAATCCCAGCACTCTGGGAGGTCAAGGTGGGTGGA


TCACTTGAGGCCAGGAGTTCGAGACCAACCTGGCCAACATGGCGAAACCCCCGTCTCCATTAAAAATACAAAAATTAGCCGGGTATG


GTGGCACACACCTGTAATCCCAGCTACTTGAGAGGCTGAGGCATGAGAATCACTTGAACCTGGGAGCTGGAGGTTGCAGTGAGCTGA


GATGGCGTCATTGCACTCCAGCCGGGCATCAGAGCAAGACTGTCTCAAAAAAAAAAAAAAAAATCGATACCAGCAGTGTGAGAAACC


CAAAACATCTTACCAATGCCTACTTTAAGAAGCAGTTGTGGAAGCCTAGTCAGTAGGAGGGTGAGATCTTTGACAGAAAAAGACAAA


TGTAAGACTACAAAGCAGTGCAAGGCTGATCAGAAAACCATGGACTGGCAAATTTTACCAAAACTCAAAGCTATTCCTCAGCTCCAG


GGCTACCTGCAATCTGTGTGTGCCCTGGTGAATGGAATTTATCCTCACAAATTGGTGTTCTAAATTTCTTAAGAAGAACCTAATTAT


GTAACTAAAAAAAAATAAATGAATGCCGTTAATCCCCTTGGGAGCTTGGAGCCTGGTGGGAGAATCAAGGAAGCCTTGGGTGGGCTG


CTGGGATGCGGGGGGTCCCTAGGTGTCTAATGACTGAGCAGAGCCCCCTGTGAGGCCACCTCTGTCCTGGGACAGCAGCACAGGCTA


AACAAAAGTTCCATGGGGTCTTCATTTGCTAGGGCTGCCTTAACAAAATACCACAGAACGGGAGGCTTAAACAGCAGATATTTACCA


TCTCAGTTCTGGTGACCAGAAGTCCAAAATCAAGAGGGCAGTAGGGTTGGTTCCTCCTGAGAGCTGTGAAGGAAGGATCTTCTGTGC


ACCTCTCTCCTTGGCTTGTAGATGGCTGTCTGTACATTCACACAGTGTTCTTTCTTTGTGGATGAGCCTGTCTCCAAATCTCTTCTT


AGAAGGACATCAGTCATTGTGGATTAGAGCCCACTCTAACAACCTCATTTTAACTTCGTTACCTCTGTAAAGACTCCAAATAAAGTC


ACATTCTGAGGTGCTTGGAAGTTAGGACTCCAACATATGCTTTTTGAGGGGGAGGGAGACACAATTCTACCCATAGCATTTGGATTG


ATTTAAAAAAGGGAAGATTCCTAAGGTGAAGCACAGAAATGAGGAGAAATAGTGAGACACAGAGATACATTTGCAGTAGAAACAAAA


CTTCCCAGACCAAGGCAGCCTTTTCCTCCAGGCAGGTCGGGGCAGGTCATGTCAGCATCTGAAAAAAAGAGCAGCTGCAAAGTAGGG


GGAAAAAACCTTTTCAACATTTTGGAAAGATCTGTAGTGGATTAAATGATACTTGGTGTCTCATCATCAGGATATTTGTGTTTCAGA


GGGAGTGAAAATTAGCCTGGCATTGTGACCTTGGGCAAGTCTCTTAATTTCTGTGGTCTTCATCGTTTGATTTTTCATTTCATCTTT


AAGAGGTATATTATAATAGCATCTGCTCCATAGAGTTGTTCTGAGAAATCAGCAAGATAGTTTTTCACCACCAAGTCTTATCGGTGC


ATGCAGCAAATTGTTTTCAGTCAATGTTTGCTGCCTTTGTCGTTATCCGGGCTGGATGCAGATCCAGGCCGCGGCGGGATTCCCATG


TCTTCTGTTGTGTGGTAGATTAAAATGAGGCACTGTTCCTGCAGAGCAAGCCCAGCAGCCCTGGTTCCCGTCTGCAAGCAGGTGCCC


TGGTCTACTGTTGAGCAAGTGGTGGTCATGGTGGTGCCCATTGGGTGAGGGGCAGCCACAGTTTGGGAACCGAGGCCTTCTTTTCAA


AACTCCTTTTTTTGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACAAAAGATAATAATAATAACCCTCTGATCTATGTTGCAAAG


GGTGTGCTTGGTCTCTCAAATAATTGCTGTAGTAACTGTCTGAATTTAGTCCTTGTATCTGAGGGAAATCCTGACAAACGGCAAAAA


TTCCACGCAGACGGTTGGCCAATTATTACAGGTAGTTCAGATAAAATGCCACAGAATCCTCTGGAAATCTATTTCAATTCTTTTCCA


AGTAGTGTTTTTGAGGAAACCTAGGTGTCTGGCTTGGTGGTTTCGGGCAATTTCAGTGATGAAGGATGGCTTCCCATCAGCACCATT


GCGACCCAGGGTACCCCACACTTGAATGGTATTGTGTCCATGGAAGGAGGAAGTGTAGGTGGGACCTGTTTGAGAGACCAAAGTCCT


CTTTTGACATAATCCTAGCACTAGTGTAGTTTGCCTTGAATCATTCGGGTAAAGGCTTTGCCTTGCTGCCTCATTTGGCTGTGAGGA


TGTTCCTGTGTAGGCTGTTTTTAGAATATTTTCATTAGTGGGCCACCAAAAGTTGGGAATTGTGAAGAGAAATCTCCTGTTGGACAA


TGTTTACAGTTTTGACTAAGCAAACGTGAGTGGCAAAATGAATTTTTGGCCAACAGTATTCCAAATATTAACTCGCTGAATCTCTTA


ACTCTCGAAGGTAGGTATTATTATTATTATCCCTGCTTTATAGATGAGTAGATAGGGCCACGAGTCAGCCGGTGGAGGAGTTAAGAC


CCAAGCCAGCCAGTCTAACTCCTGGGTCTATGCTCCTAACAACCGCATGGTGTGGTAGATTTGTCTTCAAATAAATCATGGCACCCT


ACGTGTGGCAATGGAAAGCAGTGACTTCTACTTCCCACTGGAAACCCTCGGTGAGGGGCAGGCCTAAATGTAAATGACAAAATAAAG


GATAAGTACATTTCTCCTTCTACTTCCTAGGTTCCATTGAAACATCCCAGACAGTGATCTCTCTGAGCATCTGACCAAAATAAGGCA


TTCCTTTTATTTTTATTTGCTTTTCTATCATTTAACTTGTGTTTTTCTGGAAGACTGAAGGTGTTAAAAAAAAAAAAATTAGTTCAA


GAAGAGATGATCTAGTTCGACCAGTTCTGGGTTATTTACTGAGCAGAAATCTGTTAGTGTATTCAAAGGAGAAACAACTCTTTTCAT


CAACAATAAAAATGTATTACACAATAAAGCTTTGAATGTTGAATGAGTTTCCTTTAATATATCATCTTTATTGAAAGCTCTTACAGG


TGAGAACAAATTAATAAGATATCCATGTTAGGTAATCATAAATGTTTTAGAATTTACCCAACATCTGATGATGGCTTGATATATGCA


AGGGATAGTATGAAGAGACCTGATAAGTTAAAAATAAGGCCTCTGCCCTTAAGGATTTTATTTAATAGTGGCAGTAATGCTAACAGA


CAAATGATAAAAAAAAAAAAATATATATATATATATATATATATATATATATATATATATATCAATCAGAACTGGCTCTGAGAGGAA


GAGACTGGCTGGAAATCAAGGAAGATTTCATGAAGGAAGTAGGGTTTAGGTCCTAGCTCCATGAAGATAGACCCTGTACCCCTTATT


TTGGTACCCCAGTTCTTGGCACGGTATCTGGGACATACTAGAAGTGGTGTAGTTCATTGCTATTTAAATAATTAAGTTGAACTTAGA


TGGTAAGATGTGAGAAGCAGAAATGAGGAAACATCTCCATCCAACCTCATTAAGCAAATATCCATTGTCCATTTTCTCTGGGCCAGG


CCTTGTGCCAGGCAGGGAGAGCAGCAGGGGTGAGAGCTTGGCTGCCAGAGAGCTCAGGGTGCAAAGTCCATCTGGGTGGAGGTGTGA


CTGGGTGTGGGAAGGGAGTGGCAGATAAGGCTGGAAGAGTTGGGAGCAGCATTTGAAAGATCTTGAATGCTGAGGAGTTTAAGGAGA


AAGATCTCCCAATGTGTCATTATTGCCTATATTTTTACTTGTATTAAGCAAATACAGGTTGATAGCTGACCGTGTACATTTTGCTAA


TATTACAGAAAACTAGTTTGTTAGACTTAATTTATTCATTTATAATTGATAATATCATCTTGCAATATGCTAGAATCTGAGGTTGTT


ACTTGTTTCTATGTGTTTCCAAACCAAATAAGTACTCTAAAGCAGTAATGTCTTGTTTAACTATGAGTTAATTCTAAAATGATGTTT


AGATATGTCAACCAAATTAATTATGTTGCAAAAGCTAATTTTTAAACATGCAAGGAATTTATGAATCTTGGAGTCCTGAAGGGTTTT


AATCCTAGCTTTTCCTTAAAATAGTTGTGGAATTTCAGGGCAAGTTGCTTAATTTATATAGCATGTATAAATATATATACATACATA


CATGATATTTGTATATCTCTACAGCTCTATCTCTGTCCATGCTCTATGTCATACATCTACATCTAGGTAGCTATCAAACTATATAAA


GCACAGTAGCAAGAGTTGAAATTCCAGAGTTTAAACTCTGGAATTGATAATCTGGTTGGAGGCAAGGTAATGTCACTTCCTAGCTGT


ATGTCTTTAGGCAAATTGCTTGACTTTTAACCTCAATTTTCTCACCTACAAAATGAGAAGAACAATTCCCAGCTCATTATATCTGAG


AAAATCATAGGAGCACAAACTTTTTCTTTTTTTCTTTTTTTTTTTTTTTTTTTAGACAGAGTCTCGTTCCATCACCCAGGCTGGAGT


ACAATGGCCCAGTCTCAACTCACTGCAACCTCTGCCTTCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTA


CAGGCACCTACTGCCACTTCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACTATGTTGACCAGGCTTGTCTCGAACTGC


TGACCTTGTGATCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCCTGAGCCACCGTGCCTGGCCAAGAGGACAAACTTAT


TATTGAGCAATGGCTATGTGTTTTCCATGTGAGGAGACTAAGGCACCGAAAGATGAAGTAGTATATCCATAGCCACATAGCTATAGA


GAGCAGTGCTGCGTTGCTAGGCCAGCTTTCTGACTCCAAGCCTACCTGCCATACCACTCTGTTACTGTTTTTATTTTTAATTTTAAT


TTATTATTTATTTTTATTTTTTGAGACAGGGTCTCGCTCTGTCACCCAGGCTGCAGTGCAGTGGCGCAATCATGGCTGGCTGCAACC


TCTGCCTCCTGGGCTCAAGTGATCCTCCCACCTCAGCCTCCCAGGTGAAGTGGCATCATTGTCTGGGATAAATACCCGAGGTCATCA


ACTCAGGGTAGAGAAATAGAAAACCTGGGCAAACAAGAAGTGAGTTTAAGAGCAGAGGTTTAATAGGCAAAAGAAAGAGAAAGCGGA


TTAGCTCTATCTCCTGCAGATAGAGGGGGGTGCCCGAGTGGGTCTTCCGGTTTTGTGGTGAAATGGCACAGGGTTTTATATATGAAC


TTGAGGAGGCGGTATCTGATTTACACAGGGCCGGAGAGATTGGTTGGACCAGGTGTGATGTTTGCATAGTGCTTGAAGAAGCTGGCC


TAATCTTTTATTATGCAGATGGATTCTCTACCTGGCTAGCACCATATAGTCTGTTGCTTACTGTACACGTGGTTACAAAGAAAAGGG


AAGATGGAGCCGCCGTGTTGAACATGCCCGGCCCCCAGATAGCCTTTTCCTATTGGCCGAGCTGCTGGCATTCACCTGTGGAAACTT


CCAGCTTGCTTATCTATGTCTGCAGCTGGATTCTACAGGCTGCTCTTTGTTAGAAATGATTTTGGGGCTGCTTTTTGTTAAAAGGAA


ACCTTACTGAGGACTCTCTTACCCTTACTATCTGCCTAAATAATTTATTTCCAGCTCCTGTATAACAAGTAGCTGGGATTACAGGCA


ATGAGTCACCCACCTGGCTAATTTTTGTGTTTTTAGTAGAGATGGGGGTCTCGCCATGTTGGCCAGGGTGGTCTCAAACTCCTGAGC


TCAAGCAACCCACCTGCCTCGGTCTCCCAAAGTGCTGGGCTTCTGGATGTGAACCATTGTTTCCCGCCTGTTACTGTTTTTAAAGAC


CTCTCTGCAAATCTACATCCTGGGTGATGCTTAATAAAGGATTGTTTCTTTATCTCCCAGAACATTGGTGAGGCTAAAATGAAATAG


CATTTTTACCCTTTAAAGTTCAAATATAAGTTATGCAAATGTAGGGCATGTAAAATTTTCAGGATCTAAATTTTTAGAGTGGTTAAA


ATGTTAGTGAAATTTTTTCCATGCTGGTGATATTAGTGATATGTGTTCAATGTAGAAAAACTTTAAAGAATAAGATGATCAAGTAAA


CCAAGATTATTCCTAATCTCTAGAGATAATAAAGTGATTGGAATTTTCGTGAAATAAATACATTGAAAAAATTTTCTTGACTCAGCC


AGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGACGCAGGCAGATCACGAGGTCGGGAGATTGAGACCATCGTGG


CTAACACGGCAAAACCCCATCTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTTGGGA


GGCTGAGGCAGGAGAATGGTGTAAACCTGGGAGGCGGAGCTTGCAATAAGCTGAGATCGTGCCACTGCACTCCAGCCTGGGCGACAG


ACTGTTTTCCAGGCCATGTGGAAAATTTCTCTCACATCTTAAAATCAATTAGTCATGACATGTCTCATAGTGAAAGTCACAATCTCT


GTGAAATGGGAAGCCTTAAGGAGGAAGGGAAAAATAATATCGGACAGGAGACAATAAGGACAGAGTTCAGATTTTTGTTTGATCTCT


TTTGGAATAGTAAGAAATTAATTTTTTCTTAGGTTTATTGTGTAGGTAATGACAATATCTAGAAGATCAAAGAGGCAGCTGGTGACA


TCTTTGAATGAAGAATTGTGAGCATTCTTTAGTTCTTTTCACTTGCGGAATCTCATATGTTTGTGGCTTTGAATCAAAATGTTTAGT


TATCCTGGAATCTGCCAAAATACATCTTCTCCATCTGTATAATAGGAGTGAAAGGAATACTCATTGCTGGCTGGGCATCTGTAATCC


CAGCACTTTGGGAGGCCGACGCAGGCAGATCACCTGAAGTCAGGAATTCGAAACTAGCTTGGTCACCATGGTGAAATCCTGTCTCTA


CTAAAAATACAAAAAATTAGCCAGGCGTGGTGATGGGCATTTGTAATCCCAGCTACTTGGGAAGCTAAGGTGGGAGAACTGCTTAAA


CCCAGGAGGTGGAGGTTGCAGTGAGATGAGATTGCACCACTGCACTACAGCCTGGATGACAAAGTGAGACTGCGTTTCCAAAAACCC


CAAAACAAACACTCATTGCCCATCATTTAAGACGCTGAAATGAAGAAGATCATAACAAAGCAAAGCAGTTAGATAAATGGAATTATT


GTGAGCATGTTTTGAGATGTTGGCTTGCATATTGCTATGGATGATGTGCATGAAGCTTCTGGAAGACTGGGCTGCTCCATATAGAGG


AGAGGCTGGCCTTTTGGGATACCATTTTACTAGATTTATAACTGGATATCATCCATTGATTCTTACTGATTGGAAAGACATGATTTT


AACAGACTGGTAACTAACCATTTTTTTATCTGGTTCCTTCACAGGAATTTGAATAAAGAAAACTATGATACTTCAGGCCCATCTTCA


CTCCCTGTGTCTTCTTATGCTTTATTTGGTAAGAGAAGAGGGTGTTCTTCTCTATTTGTTTACTAGAATATTTTCTGCTATCTTTCT


ACCCCACACCAGGGAAAGAATGGCTATTATTACTTAAAAAAAGATGACCTATCAAAATTAAGTTGTTGTATAGAATGGAAACATAGC


TTGTTCCACTGTGATATTTTCGATGAAATGGCTACAAATCACATGTCTGCCCTCGACTAGGGAATGTATTTTCTTTCCAGCTCTTAA


AAGCCAACACCAGTTATGGGTAATGTTGAAAACAAATCTATCTATAGCTCAGGGAATCTGAAATGACATTGCACTGATACATGAATT


AGTCTGTGTCCCTTAATCTTGACTTTCTTTTTTAAACTTTGCGCATGAAAACTTACCACCAAAACATCAAGAAAAGCATTTTCTCTA


TTTTCAGCCTTGCTCTGCTCTATACTTTTCTTCTCATCAAGGGTTTGGAATTTTCTGGTTGTCTTTAACCATTTGTTGGGTTAACCC


TATTGACTGACAGGCTTCTAGAGCTCGGAGCTGGATAGAAACTGGGGAGTCCTCACCCTTGACCTTGGGGTAAACAGTAGGTGCCTT


TTTTTAAAATCTACGTGACTGCTGAGGTTCATAAAGGTTGCCCCCAAAATTGCTGCATTATGAAACGAGATTATAAGATTTAGAGGA


AGCATTTGCTCTCTTTTTTTTTTTTTTAAAGAAGGAAGCTTCTAGATCCTCATACCTCAAATCTTACTTCCTTTCTTCTGGGATCCA


TAAATAATACATCAAATTTCAAGTCCCAAAAAATACCCTAGAGCTCACATAGTGACAGTGTGAAATTGAATGAAACTTGAAAACTAT


CAGAGCCTTCCTCCCGGGGGAAATCTGCAGTTCAAACTTTATGAGAAGCCTGAGTCCTCACAGCCTGCAGGCTCAAAGCCTGTCTCC


AGGATTGTGGAAGGGCTGGATCAAACATCCCCACTTGACCTCTCTCCTCATGCTACCCCCTCAAATGCCCTTTGTCACCTATGTTAT


CCCAGGGTAGTGACAAATTCAGACATGGATTCAAACTCGGTGCCTCCACTACCAGTGATAAGAATTTGGTGAGTTACCTAAGCTTTG


AACCTCAGTTTTCTGCCCTGTGAAGTGGATCTAATAATAGTACTTGTCTTATGGGATTTTGTGGCAATTCAATGAGATACTGCATTT


ACAAAGCTCTTGGATCAGCGACTGGTGGTTAAACACACAATAAACATTAGCTACTATAATTACTACAGCATTTTAAGTGTTCAGTGT


GTACGTCCACATGGACTCTGACCTCCATGAAAAATGGACTGTGCTTTTATCATCTTTGCAGATTCAGCACTGAGCACACTGCTAAAT


TATTTAATAATAATATCTAATTATTAGGCCTTATTTGCTTCTTGTCTGAGAAGGGAACATGCATTTTTATTCCTGGATGAAAGGTGA


AAATAAGGTTTCCTTCTCTCTACTCTCACCCCAGTGGGATTTCTATCTAGAGTGAAAATACTGCCCAACCACTGCTGGCAGCAGTGC


CTTACCCAGGTGAAAGCCACAAGCACAGCTGTCTCTGGGTGAAGTCAGGGAGTGGGATTTCAGGGGTGTTGGGAGGGAGCCACTTCT


CTCTCCTACCTCCTCCCAAGGCCTCTTCTATGAAGACTGGAAGTTTGCTTGAAGAATCTTGCCTTCTGCATAGGGCTTTATTCAACA


GAAGCACTAATTTACTCCAGACTGCGAGTAGATCTTCTGTTCTTTTCCAAGAGATAGATTTATCAGAGGGTTAGAAACACAAATACG


GCATTGATGTACTTCAGGGGCACCAAAGAGAGAGTAATAGTGATCCAGGGTTTGGGAAATGGTACTGAACAGGGAAAATCGGAGGAA


ACCAAGGCAGAGCCATCTCTTTTGGAGTTATGCCTGGGCCTTCCAGAAGGAAGATGAGTTTGGTACAAATACTACATAATCACTGCA


CTGAGCTCTTGATGGAGCTACCAAGTAGGTGAACCTGGCAATTGCACATGTCCTTTGACCTGGAAGGCAGTAACAATGTGGTTAAGA


GTTGGGGCTTGGTGGTCCAATGGCGCTGGGTCTGGTCTGGAGGTAGCTCTGTCTCTGAATGCTTTGCTTCTACTGTGGGACTTCTCT


GGAGATACTTTCTTCATAGCATTGGTCAGAAGAAATGATGTCTTGTGGTGATCAAGTCCCATTACTGCCACATAAAAGATGCTAAAA


ATGACTTTAAGATGGCAGTTCCATTCTCTTCCTTTCACCTCTTTGTGCAAGATGGAAAACGCTATTCCCTCCAACTCCTGCATAAAG


CCGCCATCTTGTCCTTTCACAGATTTCCACCATACCATCTTTCCCACTTCTGGGGAAAGCGGCTTGATGATTCACAGTGTCCACATG


CACTTTGAAATCTTTATAGCCCCAATAGTCATGTTTATTGGCAGGAAGAGAGATTTGTTGCCCCAATACAAGCACGCAACTTTGAAC


CCTGGAACCAAGACTTGATTCTCATTTTCTGATGGGTGAGCCAGCTTGTCCTTGTTGGAATAGTGCAGCCTTGTTTGTGTGTGGCTA


ATGTAGTTTTCACTGGTGTGACTAACTGAAAGACTGCTTGCTGACATGAGTGCAAAGCTGATAAGCAGCAGCTCCACAGAAAGCACT


GACCTCACTTAAGCAACCATGGTGGTACCTGGACATCTGTCCTGCACACCCAGTTCTTATGCCCTGCCTTCTAGAGGAGCTGATGGA


ACAGGAAAGATGTGGAAAAAGGAGTGAAAGGGATGAAGACCTCCCAAAGGAAGATAAACTTAGAAAGGAGGAGATGGGCTAGAAGTC


TGGCAACATTACTTTGTGAGTTAAGGATGCATTTTCTTGGCCGGGCATGGTTGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTG


AGGCGGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGTCCAACATGGTGAAACCCCATTTCTACTAAAAATATAAAAAATT


AGTCGGGCATGGTGGGGGGGTGCCTGTAATGCCAGCTATTCAGGAGGCTGAGGCAGGCGAATCGCTTGAACCTGGGAGGCAGATGTT


TCTTGCAAGTAACAGGAAATTTGACTTATTTGACTTTAGAGCATTTTAAATAAATAGGGGTTTATTTTCCTCAGATAACAAGAAGTC


TGAAGTAGGCAATCCAGGGCAGGTTTAGCAATTCCATGATGTTGCAGAGACTTGGGCTACTTTTCTTTGCTACACCATTTTTTGAGC


TGGTTTGTCCTCTCAGGGTTCATCACAGCTGCCCCAACTGCAGACACAAGGTACATTGTCTCAGCAAGAGTCACAGGAAAGGGCAAT


GGCAGCCACAACTACCCTTTTTTTTAAAATCAGGAATATGGAAGCTTGACCACTGCCAGTCGACTTCCCCTCTCATTTCATGAACCA


GAACTGGGCCACTTGGCCACCTTCCTAGCTGCAAGTGAGCCTGGGAAAGGGAACTTGGTTTACCGGTCTCTGTGGTGGGAGGAAGAA


AAGGAGAGGGCTTGGCAGTGGCCCAGGGGCAGCAAATCTAAGGCCCTACCACAAATCTGAGAACAGAAGACCAAACTTCAAAGCCCC


TGTGTTCTCATTCATTATTGCTTTTTTGCCAGACATCCAGCATCCAACTTAGTCAAGGTTCCCCAGACTGAGCGATCTAGCATAAGA


CCTTTCTCTGATCACTGGCATATTGATGGCTTTTGGGTATTCCCAGCAGGGAGCAGTTTCCATGGCAAGAGTGTGCTTGCTCTCCCT


AAATAACTGGAAAATAAATGGTTTTCCCCCAACCTAGTGGCACCTGCACATCTGTCCTGCATACCCAGTTCAGGGAGTGAGAAGACT


TTTTACTCTTTTATTTTTATTGTCTAGCTCCAAAAACCATTGGCTTGCCACATCATGCTTCTGATTTCAATCTCTTTCACCCCTGAT


TTCCACAAATGGGAGACCCAAAGTCGTGCCCAGGAAGGAGAGAAGGCCAGCGTGGGGATGAGGCACTAAATCCCTGGTCCTAGAGGG


TGCCCCAACGTGGCTGCATGACTGGCTGTCCCTTCCCGTGGGTGCCCACTCCATCTGCCTTCAGAGGTGCTGTTGTGGTGAGGGCTA


CAGTGATGCTCCCCATGTTCTGAGACTGGGAATGCTGGGAGTCACACTCTCATGCACATCTTCAGTGCAGCCTGCCAGTTTTCCCTC


CAGGTTGCCTTGGCTGTTTCACCCGCTCTGGTGGGTGCTGGTGCATAGAGGCTGAGAGGGCTGGTTCCAGAGTTGCAGGTTCAAATC


TTGCTTCCAGCCACTACCTGGGCAAATAATTTAACCTCTTTGGGTCTTAGTGTCATCACCTGTTAAACAAGGGTAACAATAGTAACT


TTCTGCCAGAGTTGTTGTCAGGATTAAATGTGCTTAGGACAGAGCTCCACATGTACTAACTTAGCAAGTGTGAGCCACTCTTCTTAC


CATCCCAGCCACATTCACTACTACTCCAGTCTTGACTTGGGTGTCTGCAGAGCCTGCTTAGCTTTCAAGTTTAGGGTCTTTGGATTT


TGGAACCATTGTGGGGCTACTGCTTAAAGTAAACATTTTGTACTTTTATTTTTTTCTAAATGAATGTAAAGAGCTAATCAAATGTTA


AAATAGTAAGCTTTGCTTAAAGTTATAGTTCAAATTCAGATTCAAATTTGGCTAAAACTTACCGTGTAACTGTGCCAAGCAAACTTT


GTACTAAATACGTCTATATTTTCTTTCTCCCCCTTATAAATTCAAAACACTAGAGTGCTGGCAATCTGCTGTAAATGTCTTTATAAA


ATAAAAAGAGTGGAGGGAGGTGTTTTATGAAGCTGGAGTAAAAACATATATAATTTAGAAGACAGTGTGGGATTGTGGAAGACCATG


GGCTTTAGTTCAGTTAGGCCTGAGCATGTGTGCTGTGTTAACCTTTTTAAGCTTCATTTGTAATATGGGGATGTTAACATTCTTCTC


ATAGAGTGATTCTTCTCATCTCACATTCTGCTCAGATGTTTAAGAAAAGCAATGGAAAGGTTTGTAACAAGCTACTTTGACGTGGTA


GAGCTTCAACAGCTATTACACTCTTTCCTGTTTTGATCAGATTTCAGCCATGATAGAATCCTATGTTTTGTATATTGGTGCTGGAAG


CCCTAATAAAATCAATGAGTGACACAGACACTTCATACAAGATGCTAATTTTCTCTTTCTTTTTTAACAGGCAACTGGATATGGCCA


AGAGGGGAAGTTTAGTGGACCCCTGAAACCCATGACATTTTCTATTTATGAAGGCCAAGAACCGAGTCAAATTATATTCCAGGTAAA


AGCTACCCTTGATCACTGTCCTCTTGATTTTGTATGCTCTCTTGGTGGACTTTTACTTCCTTATCTATTGTATAGCAGGAAATAAAA


TAAAGGCATGGCATTCTCATTATCAAGAATGATTTCAGAAGCTAAGTTAAACAGAGAGATGAGTGGCCTCAGTATCATAAGAATTGT


ACCTCACATTCTATTTGGACTTCCTCAATCATCTCTGGGGCGAGTGCTCCCAGCCCTCTGCAGGGAGCTTGGTGGCTGCAGGCTCTG


CCTCTCCCCTAGAGTAGAAAGGGAACCTGTCTCTGGAGAGGGGAATGACCATCCACCCTCGAGGCTGTCTGATCAATGAGCTTGCTG


CTTCAAGTACTGGAAGATACGGCTTCTCTGGAGTCAGTGCTAGAATGAGCTTTCTGGCCAGAGGACTGCCTTTTCCTTACCACCTTC


TCTGAGCCCCCATGTGGGCCATTGTCAAGGTGCACTGGGAGGTGGACGTTTTATTTAGTTAGATAACCATGAACAGTATCAGATGGA


GGGGCAGTCTGCAGGTGGGAATAAGGGAAGGGACCTAAGTCCCATCTTAAGTGCTATTAAAGACACAGAAATAATCCTGGAAATGTA


GTGGAGAAGGGGAAAACACTACTGTATTTACCAGACATCCCCTGAGAAAGTCACTTGGCCCTGAAGTGATTGGAGGATGCTGATGAG


CCTTCTTGGGGGTGCCCGTGACCCCTCCCCGTCCCCTGAACCAGGGAAGTGGCAGAGGTTGCTGAGCTACCTACCTTCTAAGGCAAG


TGCCTTCCATTAACTGCCAAAAATTTACAGACGGCCCTCTGTATCTGTGGGTTCATGCATCAGCAAATTCAACCAACAAAGAATCAA


ATATATTTGGGAAAAACAATAAAAATGATACAAATTTAAAAATACAGTATAATAATCATTTACATAGCATTTACATGGTATTAGGTA


TTATAAATAATCTAGAGATGGTTTAATGTATATGGGAGAATGCGAGTAGGTTCCATGACCATAATACACCACTTTATATAAGGGCCT


TCAGTATCTGTGGATTTTGGTATCTGCGTGGGTCCAGGAATGAGCCCCCACCAATGCCAAGGGACAACTGTATTGTGCTGGACAGTT


CCCCTCCACAGAGGAGAGGCTGAAAGCTATCTCTCTTCCCCTTTCTTTCATTGGTACCAGCTTAAGGCAAAGGGCCCCAGAGTAAGA


GCTGGCAGGGGCATGCTTGCATGTCTATGCAGCCCGGTGAGGTAGGGTGTTATTAGGGGCCTCCACCTCTCCAGTCAGGGAAGTCAG


GGCCTGAAGAAGCAGTGAATGTGTTGAGAGCTGGAGGTTGATGGGAATTAACTTGGTGAGGAAGGGAGGGAAGAAAGCTTAGAAGAG


GCCCGGCAGGGATGGCTGCCCTCTGCCAGGAGAGGGCAGGAGACATACCAAGGACTAGCAGAAGGCCATGCAGGTAGGGAGGATGGA


GCCAGGAGGAGCAGGTGGGAGAGGAGGCCACAGAGACAGGGAGGACCCTGACTCCTAAGGATCTTGAGTTTTTCTCAAAAGCAATGG


ATCTGAATCAAGACTCCATTGAGAAAAGGTCACTCTGGCTACAAACTAAAGGAGGAAAGAGAGGATTCAGGGAACTGGCTAGGGGAC


TCTGGCAGGGGCTCACACAGAGTTGAATTACTTACTTTTTCTCACAGACTTTCTTTTATTAACCATGTACGGAGTGACTACTATATA


TACCAGCTGCTCTGCTGGGTACTGGGGATATGGGATGACCCCGACTCCATCCCTGCTCCGGTGAGCTTACCAGCTAGTAAGAGAAAA


CTAACAAGGAAACAGACACATGCACTGAAGCTTCTCATGGGAGGCTGGTGGGATGTGGAGGGGGCAGAGGGTAAACTAAGAAAGAGT


GACTGATTTTTATTTGTTTATGTTTATTTTTAATTGACAAAATTGCACATATTGTGTACAATGTGTTTTGAAGTATACAGAGAAATG


ACTAAATGAAGCTAATTAACATATGCATTATCTCACTTATCTCTTTTTTGTGGTGAGAACACTTAAAATCTAAGAATGATCAATTTC


AAATAAAGATGGTAGTGAGTGAACAGAAGAGGTTTCATTGACTCCTAAACTGAGTACTCAAAAACGAGCAGGTGCTCACAGTCAGGA


AGCAGGTGCTGAGTACAGGATGGGAAAAAGCATGGGGGTGTGCACTTGTCAAGAAAATGACAGCTGGCATGTGGGCCAGAGTATAGA


GTGGGAGACAGGATGCAGTCAAAGGTCTGCATGCCTGCGGAGGTCAGCACGGGCTGGACTAGCCCTTCGTCCTATAGCAGGCTGCAG


GGTGCTGCTGGAGGGTTTCAACAAGGAAAACCGTAACTAGATTTGTGCTGTAGAAGCTTACTGTGTGATCACTCAGAGCATGAGCTG


CAAGGGAGCGAGCCTAGACGTTAAAAGGATTTTAGAAAACTGTTTTCAATAGTTCAACGGGAAGTGAGGGAGGCCTGGTTTGAGTAA


CTATAGAGGTCTGAATGTTGGTGTCCCCACAAAGTTCATATGTTGAAGCCTAATCTCCAATGTAATAATATCAAGAGTTAGGGTCTT


TGGTGGGTGATTAGATCATGAGCGCTCTACCTCTATGAATAGGATTAGTGCCCTTATAAAAGACGCTTGGGGGTGCCTGTTTGCCTC


TTCTGCCATGTAAGGACACATGAAAGGTGCAGTCTGTGAGGAGTGGGCCCTCACCAGACACTGAATCTGCTGGTTGGATTTCTCAGC


CTTCAGAACTATGAGCGATAAACTTCTGTTGTTTATGTTTCTGAATGAGCACAGGGGATGAGGGAACACAAAGAAGGACAACTCTTA


GGTCTCTGGCTTGCTTGACTGGGTAGTTAGTGGTGTCACTGAGTGAGAGAGAGAGAGAGAGTACAGCAAAAGATTTAGAGAAAAGTG


AATGAGTTTTAGGCTTATTGATTTTAAGGTTATCTGTGGGGCAGCCAGGTGGAGAGGTCTCAGACAGTGTTAATATGGGTCAGGAGA


TACAGATTGGGGAGACTTCCTTATATAGGTGCCAATAGAGTGCTTGGATATGACATAGATACCTGTCTGTGGTGAGTTATCTCAACT


GCTCTTAGGGGCTAGCTGAGTGATAAATGAAGCCATATGGAAAAAAGAAAAACAACAGCCAAACAACAACAACAAAAAACAGATATG


AGAAAAAAACCCAACTGCACAAATATGAAATCAAACGCTTTCTCATACTTGTCTTTAGTATTTGGGACAAGAGGGAGTAGTGGGGAC


TGTGGCAAACTGAAAGTAAGTCAAAAGGGGATAGGCTTAATTTAGCTCCAGACGATTTTCACGAGTTAGAATTTGGGTACTACTCTA


CTAGATTTTATAATTTTCCTAGAAAAGGCATAAAATGTTATATTTATATAAAATTCACTGATGTAAAAAAATTGGCATAGTTTTTTT


TTAATTACAAGCTAAATAAAACATATTTGTGAAACAAAGTTTGTGGCTACTTCTGAGATTTCTGTATGAAAAGACCCAAGGTCAAAA


TAGAGTAGGTGTTCTGTGAGTACAGGTCCACACTCCATTGAAGACAATCAGGATTGTACATAGATGCAATCTTCAACTTACAAGCTT


TACAACGGACAAACATCCAGACCTAGAAACTGTTCAGTAGGATCATTCCAGAGTCTCTGGGGATCCTAGCCAGTAAAAGTCATGCCT


TGGGCTGCTCCACTTTTCTTTTTTTGTTTTGTTTTAGTTTTTCTGTTAGTCATGCTGCAAAGTTATCCCTTCTTAGCAGGAAATGAT


AGCCTGGTTATCATGGTTGAATGTTTCTTCTTTACAGGGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTGGGGTAG


GGTGTGGGGTTGGGATGACAGAGTAGTGAGAGGAAGATGAAGGGGATTTTCTTTTTAGAATCACAGAAGCTTCATGCTAGAAAACAC


ACTGGGGAGTTTTGGTACAACCGCTTGTTTTAAAAATGGGGAAACTGAGGCTTAAGTTAGTTAATGGCAGAGCCAACAATAGAACAC


AGGTCTCCTGACTTCTAGTCAAGCACATTTTGCTCTCTCCATCTTTGTACGTGGAAAGAATGCAGCAAACCCAGCCTTGGTAAGATG


TGCTCGGAGCTCTTTGCTTCAGTGGTGGGGAGGAGGTAGGTGTACAGATCCTCTCATCCAGCACCTGGACCTACAGAGGCATGAAGA


ACACTCATTGCCCCATGAGGTTGGTTCTTGGGTTTTTAATATGTCCTCAAAAATAAAATGAACTGAACCACCATACACTTCTTTCAT


TGTGGATTTTCAACTAGTGCCAGCTCTGTACTCACCAGGGGCTTCCATATCATCAGACAGTGTGATATAAATCTGAGAGAGGTCTTT


TTTTTTCTCATTTTAAATAAGATGTAACCCTAAAAATTCATGCCTCTAAAATTCAGTAGTTTTTAGTATCTAAAAAGACGTGCAAAT


ATCACTGCTATCTAATTACAGAACATTTCCATCAGCCTCCAGAGAAATCCTATGCCTATTAATAGTCACTCTCCAGCCTCCACTCCC


CTCAGCCTTGGGCAACCACTAATCTACTCTTGATCTCTATAGATTTGCCTGTTCTAGACATTTCATGTAAATGGAATCATACAACAT


ATGGCCTTTTATGTATGACTTCTTTTATGTACCATAGTATTTTAAACATTCATCCATGTTGGTAACATGTACCAGAACTCCATTCCT


TTTTATGACTGAGTGATATTCCATCATCTGGATATATCACATTTTGGATATCCATGTGTCAATTGATGGACATTTTTTTTCATTTAT


GGCTATAATGAATAATGCTGCTATGGCTATTCATGTACAACTTTTTATGAGGACATGTTTTTGATTCTCTTGGACACACACACACAC


AAACACACACACACACTCAGTAGCAGGACTGCTGGGTCAAAGTTAATTCTGTTTAAACTTTTGAGAAACCACAAACTGTTCTCCAAA


GCAGCTGAACCATTTTACATTTTCACCAGTAATGTATGAGTTCCAATTTCTCCATATCCTTAGCACTTGTTATTATCTGTCTTTTTT


TTTTTTTTAATTATAGCTATCCTAGTGGTTGTGAAGTGGTATTTCTTTGTGGTTTTGGTTTATATTTCCCTAATGACTGATGTTGAG


TATTTTTTCATGGGGCAATTGACTATTTATATATCTTCTTGGGAGAGATGTCTATTCAAATCCTTTGCCTACTTTTAATCAGGTTAT


TTGTCTTTTTATTGTTGTAAGAATTATTTACATATTCCGTATACAAGTTCTCTCCCTTATCAGATATGATTTGCAGCAAGTATTTTC


TCACATTCTATAAGTTATCTTTTCACTTTCTTGGTGGTGTCCTTTGGAGCACAAATGCTTTGAATTTCGATGAAGTCCAATTTATAT


TGTTATTGTTATTTGTACTTTTGATGTCATATCTAAGAAACCATTTCCTCATTCGGGGTCATAAAGATTTATGTCTATGCTTTCTTC


TCAGAGTTTTATAGTTTTAGTTTTTCTATTTAGGTCTTTGATCCATTTTGAGTTAGTTTTGTGTATGGTATGGGGTAAGGGTCCAAC


TTCATTCTTTTGCATGTGGATATCCAGTTGTTCTAGCACCATTTATTGAAAACACCATTCTTTCCCCCACTGAATTTAGCATCCTCA


TCAGAAATCAATTGAATTGTTTCTGGCCTCCCACTATGATTCCATTGATCTATATATGTTTATGCCAGTACTGCATTATCTGGAACT


ACACCTTTGTAGTAAATTTTGAAATTAGAGAATGTTAAGTCTTCCTACTTTGTTGTTGGCTATTCTGAGTCCCCTGTAGTTCCATAT


GAATTTTAGGATCAGCCTGGAAATTCTACAAACAAGGCAGCTGTAATTTTGATAGGGATTGTATTGAATCAGTAGATAAACTTGGGA


AGTATTGCCATCTTAATAGCATTAGATTTTTAAATCTGTAAACACTAGGTGTCTTTCCATTTATTTAGAACTTGTTTAATTTCTTTC


AACAGTGTTTTGTAGTTTCCATTTTATAAGCTTCATATTTCTTTGCTTAAGTTTATTCTGAGATATGTTATTCTTTTTGTTGTGGTT


GTAAATGGAATTTTAAAAATATCATTTTTGGGTTGCTATTTGCTAATGGTTAGAAAGATTGATTTTTGTTTATTGATCTTTTATCCT


GAAACCTTATAATACTTGTTTATTAGCTGTAATAGTTTTTTTAGGTTCCTTAGAATTTTCCCTATATAAAATCATGGCAACTGTGAA


TAGTGATAGTTTTATTTTTTTATTTCCAATCTTTATGCCTTTTATTTCTTGTTCTTGCCTAATTCCCCTTGCTAGAATCTCTAGTAC


AATGTTAAATAGAAGTGGCAAGATTGAGTATCCTTGTCTTGTTTCTGATCTTATGGGGAAAGCTTTCAGTCTTTCACCATTAAGTAC


AATGTTAGCTGTGGGGCTTACTTCGGTGTCCTTATTAGGCTGAGAAGTCACCTTCTATTCCTGGTGTGTTGAGTGTTTTTATCATGA


AAGGATGACGGATTTTGTCAAATGATTTGCTGCCTCTATTGAAATATGTGGTTTTTATCCTTGATTCTATCAATATGGGGTACTACC


TTAATTGACCTTCATAGATTGAACCAGCTTTGTATTCTGGTATAATTTCCACTTGGTAATGGTATATAATACTTTTCATATGTTGCT


GGATTCAGTTTGCTAGTATTTCATTGGAAAATTTTGTGCCTATATTCAAAAGAGACATTAGTCTCAAGTTTTCTTGCATTGACTTTT


TTCTGGTTTGGGTATCAGGATATTGGCCTCATAGAATGAATTGAATAAGTGTTCCTTACTCTTCTAGTTTTGGAAGAATTTCTGAAG


GTTTGATGTTAATTCTTCTTTACATGTTAGGTACAATTCACTAGTGAAGCCATCTGGTTCTGGGCTTTTTTGTGTGTGGAAATTTTT


TGATTACTAATACAATCCCTTGTTATAGTTCTATTCAGATTTTCTATGTGTTCTTGAATCAGTTTTAGTAGTTTTTGTCTGTCTAGA


AATTTGTCCATTTGATCTAGGTTGTCTAATTTGTGGGAAAACAATTGTTCACAATATTCTCTTTAATACTTTTTGTTTCTATAAGGT


TGGTAGTAGTCCTCTTATATTCCTGATTCTAGTTATTTGAATCTTACCTCATTTTTCTTGATCAGTCCAGCCAAAAGTTTGTCACTT


TTGTGGATCTTTTCAAATAATCAACTCTGGTTTTGTTGACTTTTCTCCTGTGCTCTTATATTCTCCATTTCATTAATTTCCACTCTG


ATCTTTGTTATTTTCTTCTGCTTGCTTTGCTATTCTTCTTTTTCTTGTTTTTCTTTTCTTTTTTTTTTCTAAGTAGAAGATTAGGTT


CTTTGGGATATTTCATCTTTGTAAAGTATGAACATTTACAGTGATAGATTTTCCTCTAAGTACTGCTTTATCTGCATCCCATAAGAT


TTGGCATGCTGTGTTTCATTTTCATTTACATCAAAGTATTTTCTAATTTCCCTTGATTTCTTCTTTGACCTTTGGTTTTTAGAGTAT


ATTGTTATTTTACATATTAGTGATTTTCCCAAATTTCCTTATATTGTTTTTAATTGTATTCAATTGTCAAATACTTTGTATAACTTC


AATCCCTTTAAATTTATTGAGACTCGCTTATGGTCTAACATATAACCTCTCCTGGAGAATGTTCCATGTGACTGGCTTTTGTTGGAT


GGAGTGTTGGGTGTTTGTTAGCTTCTAATTGGTTTATAGTATTGTTCAAGTCTTCTGTTTCCTTATTGATTTTCTATTCTATTATTT


AAAGTAAAGTCTTGAAATCGTCAATTATTACTGTTGAATTATTTAATTTCCTTTCCATTCTGTCAGCTTTTCTTTCATGTGTTTTGA


GGTCCATTGTTAGGTGCATATATGTTTATAATTGCTATGGTTTCTTGATGGATTGACCCTTATATCATTATAGAATATCCCATTTTG


TCTCTGAAAATTTTGTTTTAAAGTCTGTTTTGTCTGATAGTAGTATAGGTTAATTTTATCCTCATTTTGAAGGATAGTTTTGTAGGA


TTTACAGTTCTTACTTGGCCACTCTTTTTCTTTCAGCACTTTGTTTTTTTTTTTTTTTTTGGTTTGTTTGTTTGTTTGTTTGCTTGT


TTTTGTTCGAGACGGAGTCTCACTCTGGGAGTCTCACTCTGTCCTCCAGGCTGGAATGCAGTGGCACAATCTCAGCTCACTGCAAGC


TCCGCCTTCTGGGTTCACGCTATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGATGCCCACCACCATGCCCGGCTAATTT


TTTGTGTTTTTAGTAGAGATGGGGTTTCACCGTGTTAGCCAGGAAGGTCTCGATCTCCTAATCTCGTGACTGCCCACCTCAGCCTCC


CAAAGTGCTGGGATTACAGGCATGAGCCACTGCACCCGGCCTCTTTTAGCACTTTGAATGTGTCATTCCACTGCCTTCTGATCTCCA


TGGAAAATTAGCTGTTAATTTTATTGAGGATCCTTTACATGTGATGAGTCTATGCACTTTTAAGATTCTCTATCTTTCAAATGTTTA


TGATGTGACTAAATTTGGATTTCTTTGAGTTTATTCTATTTGGAGTTCATAGTGATTGTTGGATATATAGATTCATGTTTTTCTTAA


ATTTGTGAAGTTTTGGGTCATTCTGTCTTCAAATAATCTTTTTTCCCCCTTTTTCCTTTCCTTCTGGAACTTTTATTATGTATGTGT


TTTTCTGCTTGATGGTGTTTCACTGGTCTCTGGGAATCTATTCATTTTTGTTCATTTTTTTTCTTTCAGTAATCTCTATTAATCTAT


TTTCAAGTTCACAAATTCTTTCTTTTGCTAGCTCAAATCTGCTTTTGAACACCCTCTTATGAATTTTTCCTTTCACTTATCATCCTT


GTCAACTGTAGAATTTCTATTTTAAAAATTTCTATTTTTAATCAATATTCTATATCTGATGAGGCATTGTTTTCAAACTTTAATTCT


TTAGAGATGATTTCCTTTAGTTTTTGAATCTATCTAAAATAGATTTTTAAAAATCTTTAGTAAATCCAACATCTGGGCTTCCTCAGG


GACAGTTTCTATTGACTTTTTAATATTTTTGTACATTTCATAATTTGTTGAAAACCAAACATTTTAAATAATGTGATGTGGCAACTC


TAGAAATCATATATCTTTCTTTTCCTGGAGTTGGTTGTTGATGCTGTTTGTTTGCTTAGTGACTTTCCATAATGAATTCTGTAAAGT


CTGTATTCTTTGTCATGTCTGGCCACTGAAGTCTGCTCAGTCAGCTTAGTGTTCAGCTAATGACTAGATAGAGATTTCCTTAAATGC


CTTAAGCCAGTAAGTCTCCTGGTGTTTACCAAGGGGCACTGTGTGCATGTTGGGACACAACCTTCAACTATGTGGCAGGCAGTTTAC


AACTCTGCCTTCGCCTTCACTTTCTGCTTATGCAGAGCCTCCAAGTCAGCCAGAGGTGAGGGATTAGGGCCTTCTCAGGTCTTTCCC


AGGCATGCACACAGCCCTGCTCATGATACTGGCCTTGTAGATTGCCAGGAATATATTAGAGATTTTCAAAGCCCCTTATGGACATCT


CATTTCCCAGCTTTCCCTTTTAAGTGTTTTGGTCAGCTGCTTCTTTGCTTCAACTGTTATCACAGCCTCAGGCAGCTGCAATGTTGA


ACAATTGCTAATGGTTGTTTTCAACAAATGCCCCAGGGGAAAAATTGTGTGTGGTGTATGAATTCTGAGTCCGGTCAAATGAAGATA


AGTGTTGTAAGTAGATGTTCCCAGGGAAATGCCAACAGGATAGATAATGATAGTTCTCTGGTGATGGAGCTTTTGGGAAGCTACAAA


CGCTTCTCACCCTCTCCATGGTACTGTGGTGTGAGGCTGTTGCTTTCAAGGCTACTTCAGATCTTAGGAAAGGACCATGGGATTAGG


GTGCATTAAAACACCACAAACCTTAGTTTTTTTTTTTTTTTTTTAATAAACATTCCTTGGATTTTGCAAGCATCTGGTTAATTTCCC


ATATTCTTAAAAAGATGATATTTACAATTTTTGCCAGTGTTCTCATTGCTTTTATGGAGGAGCAGTTTTCTGTAGGCCCTTACTCCA


CCTTTCTCACTGATGTCCAGGTCTTTTTCTGAAAACACAAAATAGCAACATGTTCATTTATTATATAAACAATATAATATCAACAAG


CAAACATGCACAAAAACTTTTTAACTTACAATCTTACCCATTTAACACATCAACTCTTCTTATATTTTAAATTCCATTTCTTACCTA


CTGACATGAATTCTTTTGGTACCATAACAGTCTAGATTTACTCTCAAATTTACTTCTGTTACTTTACATCATTGTTTCTTATGTTTC


TTCATAATTTGTAGAATGAACATTTTAATGATTAATATTCTGTCAAGTTCATGTGCCATAATAATTTCACTGTCCTTTTTTTTTGAC


CATTTAGGAGTTTTCAATCTTACTGGTATTATAAATAAAGTTACTTTCACTATAAGCATGTACTTGTTTGAAGAAATATTTCCTTAG


GGTAAATTATGTATAGTAATGTTTGCTATCAAAGGGTACAAACATTTTATGCCTCAAGTTATTTCCAAAAGGATTATAGGAATTTAT


ATTTCCATCAACAATGTTTCTTTATATCCATACTAACTTTGATATTGCTTTTAATTTAATAAAAATATATAAAAGTATACTAAAACT


TAACGTTGAACAGCTTTTATGTTTTCTTAGTTTTATGTGAATTTTCTGTTGCTGTGGTCTTAAAAGTGATATAGCCATATCTATGAA


TATGGTGGTCGGTATTTTCTCCACTTCTGAAAAAGTAATAGATTATCATATAGCATTTGCATTAAGTTAAAGCCACTTATAAATTCT


TTTCCTTAACATTAACGTGTCTATTAATCTTTGTCACAATTTTTAGAAGTGCTAAATGACATATTTTATCCTAGAGAGAAAGCTACC


CTTTTAATGCTTCTTAGAAGCTAGTAATGTCATAGATTTCAGATATTACCAAAAAGTCTCTTTTAACCCCAGCTATAATTTAAAGCA


TCAATGACTTTTGTCAATGTATTGAATAATAGTATACAGTCTCTTGAGGAAAATGTATGTTAAATGTTACACAGTTATTGTGCAAAC


AAACTTTTAGAAGGTACCACTTTAAAAGTTGAGGATTTCTTATTTAGTAATTGAACCAATGAAAATTTTACCTGAAATTGGTGACTT


TCTACAAATTCCACAACATTGTTTTTTCCCTTACAACTTAATCTGTTTTTTGCTTTTTCCCCAGTTTAAGGCCAATCCTCCTGCTGT


GACTTTTGAACTAACTGGGGAGACAGACAACATATTTGTGATAGAACGGGAGGGACTTCTGTATTACAACAGAGCCTTGGACAGGGA


AACAAGATCTACTCACAATCTCCAGGTAAATTGATACCAGCTGAAGGGATCTAACTCCAACCTCTCTGAGCACCCTTTGTTCTGGAA


GTATGGCTGGCACCTTCCTTCCTTGCACAGAATCCAGTTACAGCTTTCCTTACATTAATGGGACGCTTTGCAATCCTCACATGTCCA


TTTCTTACCAACTACAGAGGGGTGTGGCAAACATATCCTTTTCCTTAGGCTTTTTAACCAACGTAACCCCACTTACATTGCCAGGAC


CCTCTGATGGCATTACTTATCCAAGTAAGACCATGCTTAGGTACTTGGATCAAAAGTCAGCACATCTCTGATACTTCAATGGTATCT


GCCTGTGGCTGTTGCATTGGCTTGGGACCCATGAAGAAGGCTGTATCGGTGCTGGGATGGAGCTCCTTTGGGCGTTGGAAGAAGCAG


AGGGAACCAGTAGCCAGGAGCTGACTAAAAAGACCCGTCTCCCTCTCTTTCTCCTTTAGTTTTCACCGTTGGTATCTGAATACCTAG


GAAAGTCAGAGAGCCTACTATGGAAAAAAGAGTGAGATAAAAGCTTTCTGTCTGGTACTTCTGCTGCAGGCCTTGCAGGCTGACCGC


CATAATGGCTCTGGAAGAGAACACAACACTTTCATATTCTCAGGGGTCACAGTGCTCTTGTTTCATGGACTTCACCCATCCAGAACA


GATGCATGTTCAGTGTCCAGAACACCCTGCTGATAGAAAGTCACCATCATGATTAGCCAGGCTTAACTGATACAATCCCTGTTTTAG


CATTTCCCAATTTGGCCTTTTGTGAGTTCTTTCTCTCCTACAGTCACCAGGCCATTGGTTCTTTGAGTTCTAATTTCCTTCAAGTGA


TTTTTGGGCATGTGACATGAAGTTCAGTCTCACCAACATGGTTTCCTTTTCCTCAACATCAGGTTGCAGCCCTGGACGCTAATGGAA


TTATAGTGGAGGGTCCAGTCCCTATCACCATAGAAGTGAAGGACATCAACGACAATCGACCCACGTTTCTCCAGTCAAAGTACGAAG


GCTCAGTAAGGCAGAACTCTCGCCCAGGTAACAGGCAGGGGCCAGAGATATTTATGCAAAGATGGAAGGGTGTCAGGTGGAAGGGGC


AGACTTGTGTGGCTAATAGCTGCAGCTGTCACTCAATAAGCACTATCTTACCTACATTTCACACTGATTTGGGAGTTGTTTCACTAT


CTCTATTGCTCCAGAGCATGGTCTCTCAATGCAGCACTATGTATTGACATCTTGGGTCTGATAATTCTTTTTTTGGTCAGAGGCTAT


TCTGTGCCTTGTAGGATGATTGGCAGCATCCCCCTGACCTCTATCCACTATGTGCCCCCCTGCCAAGTTGTGGCAATAAAAATGTCT


CCAGGCATTGCCAAATATCCTCTGGTGGGTGGAGGGCACAAAATCCCAGTACTTTGGGAGGCTGAGGTGGGAGGATCACTTCAGCCA


GGAGTTTGAGAACAGCCTGGGAGTTTGAGACCAGCCTGGGCAACAAAGTGAGATCCTGTCTCTACAAAAAATAATAGTTTGCCAGGT


GTGGTGGTGCATGCCTGTAGTCCTAGCTACTTGGGAGGCTGAGGTGGCACAATCACTTGGTCCCAGGAGATTGAGGCTGCAGTAAGT


TGTGATCACACTATTGCACTCGGTCTGGGCAACAGAGTGAGATTCTGTCTCAAAAATTACCCCCAGTTGAAAAACGCTTTTCTAGGG


TGATCTCTAAGATACCTCAGAGCTCTAGAACACTCTAGAAAGGTAAGCTTACTCCCCTGTATCTTCTTAGGAACCTCCATTGATATT


GTCACTGGTGGTTTCCAGCTCTTTTCTTCTCTTACATCCCATCTGTGGCTCAGCCCTTCTCTATGCTGCATTGACCTTCTACCTTTC


ACTTCCACAAAAGCCCTTCATTAAGCCCTTCATTAAGGCCTTCATTAAGGCGTGAGTGTGTCCAGCAGGCACCTAGGAAGGAGCATC


ACCTCCTAACAGTTGCACACAACATAAATGAATATTAGACTTCAGAGTTCTTAGAAATATGGTTTATCTATTAACATTTACTGTATT


AGAAATTTTAAAGATATTCATTTAAAATAATACTAATCAAGACTTGGGGCCATTTGCATCATCCCACCATCAAGCTTCTTCCTTCTC


TTTCTTCAATGCCTGCCTCCGAGAATTCCAGGAAAAAATTCACTTCAGTTTATTATGTGGAGTGATGTCCCTGTCCCTGAAGCTGCA


TACCAAAGACTCACACAGACTCTGCTAAATGTGTAGGCTCCAGGCCGTACCTTTTCTCTCTTCACTAATAGAATCTGCTAGAGAAAT


GGCTCTCAAACTTTTTGGTTTCAGGACTTGTATATTCTCTTAAAATTTACTGAGGACTCCAGAGAACTTTTAGACATGTGGGTTATA


TCCAGTGGTGTCCTGGTAAAGGCTTAACAGCTATTTTTCTAGGGGGACAAAGCTCTGATTTGTAGAATTTTCTAGTTTCCATGTTGC


AAATACTCCTACCATGGCCTATTTCAAGTGACCATTGGTATTAATAATTGACACACAAAATTTCTGAAAATTCAACAACTGAGTCTC


ATGAGCTGTCTCTAGTACATCACTGGTTATATCTATCAACATTTACTATATTAGAAATTTTAAAAAATTATTAATTCATTTAAAATA


ACACTAATCAACATGTTTTAATGAAAAATAATTGATTTTAAAGACAAAAATAGTAAGAAAAATGGCATTGTGTTAATCTTTGCAAAT


CTCTTTAATGTCTGGATTAATAGAAAACGCTTGGATTCTCATGTCTGTTTCTACATTCATTCTCTTGCCATGTGCTAGTTTGGTTGA


AATATATGAAGGAAAATTAGCCTCACACAGATATGCAGTTGGACAAGAGAGGAATATTTTAATAGTATTTTCAGATAACTGGACATT


CTTTAGTACTATACCCAAACTCAATAAATTGTGGTTTCTTAAAGATTAGTTGCAAAGTGAAATCAAAATTAATACCATATTTTCCAT


TCTTTTACACTACAATTCATTAAATTATCTTGTACTTTAAATGGATCTTTTACAGAAACATGACCTTTAGCTTTACAGAGCACTTGA


ACAGTTTCAGGGACCCTTAGAGGTTCTTGGACCAGACCTTGAGAAACCTTATTTTAGGGAAGGGGGGAGTGGGATAAATATTTATTT


CCCCACTGGTGTGAATTGTCATACCTTTCCCTATTATATCTCCACTTTTTAGATGGAAAAAGTAGCTATGGTTGGTTTGGGTTTCAA


TTAATATCTTTTTTTTTTTTTTTCTGGGTACGTCTTGTTAAACAGGAAAGCCCTTCTTGTATGTCAATGCCACAGACCTGGATGATC


CGGCCACTCCCAATGGCCAGCTTTATTACCAGATTGTCATCCAGCTTCCCTGATCAACAATGTCATGTACTTTCAGATCAACAACAA


AAACGGGAGCCATCTCTCTTACCCGAGAGGGTAAGTTCAGGGGTGCCCTGGTAGGACTGTCTCGGTCAGAAAAAGGGAGTTTGGTCT


GTCTCTTCCAGAGACACTTCCTATTCCCTTCTCCCCTACTTCTCACAGGATCTCAGGAATTGAATCCTGCTAAGAATCCTTCCTATA


ATCTGGTGATCTCAGTGAAGGACATGGGAGGCCAGAGTGAGAATTCCTTCAGTGATACCACATCTGTGGATATCATAGTGACAGAGA


ATATTTGGAAAGCACCAAAACCTGTGGAGATGGTGGAAAACTCAACTGATCCTCACCCCATCAAAATCACTCAGGTAGTACCCAAGC


CCAAGTAACACTGAGAGCCAACTAGATAAATGGCTTCACTTTGTAGAGACCCACCCTCACAGTCTTCACTGATACACTTATTAGATA


CCTTTTTCATAGCATGATTATAAAGCAAATTATATAGCCTCTGGCCCCGAGTCACTGGACTTGACCATGCATCATGGGCAGGCAACT


TGGATGCAGATATTATGTTAGGCCGTTTTTGTATTGCTATAAAGAAATACCTGAGGTGGGGAATTTGTAAAGAAAAGTTTAATTGGT


GCATCGTTTTGCAGGCTGTTCAAGCGTGGCTCCAGCATCTGCTTCTGTTGAGGGCCTTGGGAAAATTACGATCATGGCAGAAGGCAA


AGGGGGAGCAGGAGCATCATATGACGACAATGGGAGCAAGAGAGTTAGGTGGGAGGTGCCACACACATTTAAGCACCAGGTCTCATG


TGAACTCAGAGTGAGAACTCACTTACCACCAAGGGCGTGGTGCTCAGCCATTCACGAGGGATCTGCCCCCATGATCCCACCTCCCAC


TGGGCCTCACCTCCAATACTGAGGATTACGTTTCAACATGAGATTTGGAGGGGACAAACATCCAAACGACATCAGATATATACTTTT


GCTTTCAGAGAGAACTTCACTCACCCTCACCTTAAAAGTTGACAGCAGTGATGTTTGTTGTTCCCTGTTAGCAGTGTGGGATATGGC


AGCCCTGCAGTGGGTCATTTATCGTGCACTATGTATGGACATGGTTTGATTTGGGGGTTGCAAATAGATTTGAAAGGCTGCTGCTTC


TTATTGTGGAAAAAATCTTGACCCAATAGACTTGCCCATCTTAGGCTGAGGGACGGAGATAGGACTGGCTAGGGGTAAAAGGATCAT


AGTAGGGAACCTTTCCCCTTGGAAACTCCCTCACCCCTGGCACTCTATCTCCTGTGTGTGCCTCTCCCCTCCGTTCAGATGCTCCTA


CTTCCCCACCTCTGTGGCATGTGCTCTTACCCTGGGCCCCCTCCTACCTTAGCTCCTAGAAATTCACTCTGGACTCCACCCAGATTT


GATATTTTCTGGAAGCCCAGGAAATTCCTCCACATGAAAGCTGTGGGTTAGTGGGAGATCCCTGGATTTGGAAGCAGATGAACAAAA


TCATATTCCTGTTCCATCACTTGAATGACTGATCATAAACAAGTCATTTAACTATTCTGAGCCCCAATGTCTCATCAATAAAATAGG


GATAATACTTCAGTGTTTTGTGAAGATTAACTGAGACAGTATCTGTAAAAGTAGATAAAAATATTAGATATAAAAGCTATTATTATG


AAGAAGTACTAGTCTGTAGTTCCCCTAATTTTTTTTTAATGCTACTATTGTTAAGGGGCCCTGGAATGGCCTATTCCATCATATTTA


TTGGGATGGGCCCAGGGACATTTATTTATTGAATGTTGAATTAATGAACTTCAACTTCAGGAGGGGAAAAAAAGGAAGAACAGCAGG


AGAATTCTGATTTCCCAGTTAGAAAGAAAGCATGTCAGCACTCATTACCATGAGAATTTCTGATTGGGGGCCTAGACTAAAGTCTTT


CATAGCTATTATTCAGGTTACTCCCAAAGGGATTGGTAAATGCTGCAAAGAACTCATGCTTAGTTGCCTTGGGGCTGCCAAGGGAAA


ATTCTAGAGTGCCTACCCAATTTTCAGGTCTGGAAAAAATGCTCTGGGTGTTCTGAAACCCAAAAGGAGAGAGGGAGAAAGAGAGAG


GGGGAGAGGGGGAAGGAGGAGCGGGAGAAGGGGAGGGAGGAGGGGGAGGAGGGGAGGGGGAGATGGGAAGAGGAACTCAGACTGAAT


TTTTAGAACACAAGAGGAGCCCACTTTAGAACCAAGAAGGTAGTCTGCAGGGACAATGGGTGATGCTTAAATAATTAGCAAGGGACA


AAGTTGCTGCTGTGATATCTTCCCAGGCTGCTCTGAGAATAGTTTACTGTGGAAATTTCAACTAGCAGTAGGACCTTGGGCAAGTCG


CTTAAATTTTTTGTGCCCTAGTTTCTTCATTATAAAATAGAGATAACAGTAGTCTGTACGTCAGAGGACTGTTTGGAGATTAAATGA


GATATAACACATAAATATGTTTAGAATTGTGTCTGGCATGTGGCAAACTCAGTAAACATTATTAATATATCAGACCAGGCTCTGTCT


ATATAGCAAGTAGACTGGTCTTACTTGTGTTTATTTTTTATTTTTGCCAGGTTGTTTACAAACAACCCTAGGAGTTGGCAGTTATTC


TCATCCCTGAAGTCTCTCAAAGGCTAATATTTAGGAAGGAATGTCCTTATTTTTGTATCATTTGTCTTACTTAATGGCATGGAGAAG


ACTTCAGAGTGGCCCCTATTGCCCCTGTTCATCTTCATTGGTGAGTATTAGATGCTCACCATACATTGTGGCTTAGTCCTCAGACAC


TGCCAGCCACAAAGTACATTTTGTTTCTTAAATGGATGGTTCGTGGATAGAAAGCTTTCACAGTCAGACTTCCAAAAGAAAGCAGCC


CAGAAACCCTGTAGAGGGTTTGTGAAGAATTGCTTTAGAGAAGAAACATTTCCTGGTGTGCTTTTTTCGAGCAATATAACTTGGTGG


GGGGAAAAAGGCTTATTTTAGGTTAAAAGTGAAAAACGTAATTCAGTTGTTACAAGAAACCACAAACATACAAGGTTGTCAGAGATT


TCAAATTGAGAACTAGAAAATTATTTCCTTTCCAGTTCTCTCAGTCCAAATACAGCTTTCCTCACAACTGACTTTGGGCCCTGTAGG


TCCGGTGGAATGATCCCGGTGCACAATATTCCTTAGTTGACAAAGAGAAGCTGCCAAGATTCCCATTTTCAATTGACCAGGAAGGAG


ATATTTACGTGACTCAGCCCTTGGACCGAGAAGAAAAGGATGCAGTGAGTAAAAGAGAAGAGTTTCACAGGCGACAAGACAAAGTCC


TATGCCCATCTACAGTTGAGACCAAAATGGATTTTACTTTAAAGAAAAAAAAGACACACATTTCAGACTCCAGCATATTATTGGTTT


TCAAAGACATGATAATTTTCACATAATTCTGACCCATCTCAGTTTTTAAAATTTTCCAATTCTAAGTGAATTAAAAATAAGGGAGTA


AATGACATAGAAATGAAACAACGATTTTCTCTGCTTTTGACAGAGGGTGGTGGGTGAGTCTTGCCTTAACTCTGACTTTCCTGTTGT


AGTATGTTTTTTATGCAGTTGCAAAGGATGAGTACGGAAAACCACTTTCATATCCCCTGGAAATTCATGTAAAAGTTAAAGATATTA


ATGATAATCCACCTACATGTCCGTCACCAGTAACCGTATTTGAGGTCCAGGAGAATGAACGACTGGGTAAGAAATGAGAGCTGCCTA


ATGCTGTGTAACTGCCCTCCATTTCTCTCCTCTGCTGGGTAAAAGGTGAGCAGGAGACCTTACTGGGAGTCAGTAATCCATGTCTTC


CACAGCATAGAGGTTGACTGTACCTTGGGAGTCACGTAAGGACCGTATTTGGGATCAAACAGTATCTGGATAGTATTCTTAAATTGG


GGCTTTTATAGCTACCATTACCGCTACTACCATTATCACTATCATTATCAACCTTACTACTATCATTAGTATCACAGCCACCTACAC


TAGTATCTTATATACATGTATATAGGGATATCTCATTTGCAGGATTTCCCCATACGTTATTTGACTTCTAATAATCTCATTAAAGAG


ATAATCTCATCACATTTGCCAAAGAATTTAACATTTACACCCAAAGTCAGACAGACACCCTGCAATAAGTAAGCAAACACCAATGGA


AGTTGACTTTTGACCCTTGGGCCCCCCTTTCCAAGAAGCTGATAATATAATTCAAGAGGCTGCTAGATGAAGTCAAATCCCATCTAT


TTTTATCATTTTTGCTTTGTCTTGCTATGTTTTCTTTTACTGTGTCCTGTGATAGCTTTTTAGTTTTTGTATAGGAACAACTACTAT


AAGAACATTATAATTTCTGGGAGTTTTATGGCTTCTCTGGGTTTGGGACAATGCTTGTCTGTTTCCCCCTTGGCAGTGAGCCCCTTG


ACTGAGCAGACTGGCATTTCTTGAACTGTTTTGTTCTGTTGTGCTGTGTACCTTTCAGAGGCTTCCAAGTGTAGCAGCCTCACGACT


ATCATTTCTAGAGCTTCACTGCCCTTGTGGAGAGATCCTCCTGTGCTTTGTGGATGGGCTCACATTTTCTTTTCGTCCCTCCATTCC


TCACCAGACACACCTCTGACAGAGTGGCTGCCTTCCCGGAGGCTTGGTGGGCGCTGCTGGAGCGGCTTGCTCACACTGCTCATTATT


TTTCTTCTTGCTATCAGGTGTCGTGTGGGCTGCCTTTTGTCAGTGTGTTCTGTGTCACTGTGTTCTGTGCAGGTCCTCTCTGTTTCA


TTTTTCTCAACTCTTGCCACAACAGGAAGAGTTAATGCCAGCTTGAAGGACTTCAGTTCGTTATAAGGAAGAATCTTCTCACAGTCA


CAGTAGTGTAACAGTAGCCAACAAACACGTGTGCCATCACCTTCTTGGGAAATCTGGGATGGTCTGTGACACTGAATAAAGGTGGAA


AATCTTTGACAACTTTCTTGACCCGGACATGACACTTCAAGCCTCTTTTACATTGGGCCAATCATATAGTCTATTTGTTACCTATTT


CTGCAAAACAGATTGCTCTAAATCTTGGCAGCTTGAAACAACAAGCATGTATTATGTCACAGTTTCTGTGAGTCTGGAATCTGGGTG


AAGTTCAGCTGGATACCTCTAATTCAGAGAGTTCTGAGAGAGAGGGAAAGAGTACGGCACAGCAGGAAAGGACAGGCATCAGTCTTT


CTATGACCTAATCTTGGAAGCGATCCCATCACTTTTGCCATTAGAAACAAGTTGCTAGGTCCAGCCTGCACTCAACAGGATGGGGTT


CTGAAAAAGCACAAATATCAGGAGATGGGGGTTGCTGGAAGCTCTTTTCGAGGCGCCTACCTCATCTGCGAAGAGGATAGTGCTGGT


TTTCTGAGACTGAAGAAGTCATTGTTGGTAGAATAAATTTTGAAGGGGCTCAGCTTGCTATTTGCCTCTCTAAAGGTGAGAATTTAT


TTTGTAAAAATATTTCAGAGTCTTTAGTGGACCAAGAATTCTTATAAATCAACTGAGCATATTCTATATATGTAAGCTTAAAAGGGT


ACAAGACAATGCTCCTGCCTTGTGGGGACTTACTGTCTAGCTTAGCTGATAGGACATGAGTAGGTGGAAATATTCACAAATAAAACC


TTGATAAAATACTGAATTAGGCCAGGTGCAGTGGCTCATGCCTGTAATCCCACCCAGCACTTTGGGAGGCCAAGATGACCAGATCAC


TTGAGGCCAGGAGTTCGAGACCAGCCTGGCCAACATGGCGAAACCCTGTCTCTACTAAAAAAAAAAAAAAAACTGCAAAAATTACCC


AGGTGTGGTGGTGCATGCCTGTAATCTCACCTACTTGAGAGGCTTGTAGAGATTGCAGTGAGCTGAGATCATGACACTGTGCTCCAG


CCCAGACAACAGAGTGAGACTCCATCTCACACACACACACAAATATATATATATATATATATATATATATATATATATATATATATA


TATATATATATATTCCCCAGTGTATTTACATTCTCCTGTTTGGTATCTTGTGGAACTCGTGTCCCCAAGTCTTAGCAACACTAACAT


TTATTCTTGAATCCCACTTGCCACCAAGTCTTATGTATTCATACAGAAAATTTAGACTCTCATAAAAACCCCACCTCCCTAAATATT


TCTGCATATTTCTAAGAGATGCTACGTATACTCCTGTATCAGTTTGAGTTCCACTTGTTCCAGGCCTCAGTCACTCAGAGACATGGT


TTTCCTTTCACTTCCGACTGATCCACAAGGTCCTCTGCTCCCAGCGAGGGGTGTCCTCTGATGCCAGCAGTCCTCATGGTGCCTCTG


GCAGCATGGAGGTTTCCTGTGAGTGAGAGGAGGACAGTGTCCTCAGTTTCTTGCTCACTTGCTGAGGGGATAGGGCTATAGCAGGGC


TGCTGAGACACCAAAGGACCACAGAATTTAGTAAGACACTCTTTCATCCCAGCACACAGATACTTTTCTTGCAAGGGCATATGCATG


CCATATGCACTAGAAACATATTCTCTTCTGTCCTATTCATTCCGATGGTCCCTGCATGCAGCCCATGAGGCACATCTGCATGTGTCC


AGCTCCACTGTAGACATACATAGGTACTTTCTTTTTCCTCCCCCAACCCAAAACCAAAAAACCTCTAAATTTCCATATGCGTCAGTG


GATGCAAACTGTGTCAGCTGATGGGCGAGGGGGTGTAACTCCACAAATGGGATGAATTCAAGTTTGAGCTCCTACGTGGGATTCTTG


CTACATATAAAGAGACCTACAATTCCCACCTCCCAGAGTAGGATGGTCTGGAACCTGTCAGAACTTGCCCAGAGCTGGGTGCAGAAC


CGAGTCATAGCCACTGGTTTGTAGAACTCCCTGGACTGAAACCCTCACAGGAATAAAATACTTAGGACCACAAACTACAGCAAGGTG


GAGAGGATCCTGCCTGGTCCCTGCCCTGTGTTATCTTTGGAGTAGAGTCAGTTTCTGCAATTGTTCCATGAAGTTGCTTAGATGCAA


TCTAGGGTTGGCTTCTCTTTGTTTAGTGATACCATTTGCCATGTGTATTAGCGTCCTAGGGCTACAGCAACAAATCACCACCAATTT


GGTGACTTAAAACAACAGAAATCTTTTCTCTCCTAGACCTGGAGGCTGGAAGTCTGAAATCAAGGTGCTTGCAGGGCAGCGTTCCCT


CCAGAGTCTCAAGGGGAGAATCTTTCCTTGCCTCTTCCGGCTTCTGTTGGCATCTGGTGTTCCCTGGCTACTTGTGGCAGCCTATCT


CCAACTTCTGGCTTCCTCCTCCAGATCATTTCCTCCTCTGTGTGCATCTCTGTGTTTCCCTTCTTATAGGGGCACCTGTCACTGAAT


TTAGGGCTGCCTCTAAATCCAGGATGATTTCATCTCCAGAGCCTTAACTAGTGACATCTGTGAAGGTCTTATTTGCAAATGAGTCCC


ATGCTCAGGTTCTGGTAGACATGAAGTTTTGGGAGGGAGTACTAGGTGTTATGGGCTGAATGTGTCCCCGTGCCCCCCAAATTATAT


GTTGAGGTTGTAACCCTCTGTTCTAGGCTACATCTTCCCCCTCCCCCAGATTCATAGGGTGAAGTTCTAACCCCTAGTACCTCGGAA


TGTGACTATATTTGGAGATAAGGTTTTAAAAGAGGTAATGAAAGTAAAATGTCCTTACAGTGGGCCCTAATCCAGTATGACTGGTAT


CCTTATAAGAGGAAATGTGGACATAGGGAGGTTCAGAAGGAAGGTGCTGTGAAGGCACCGGAAGGAAAAGACAGCCACTCACAAGCC


CAGGAGAAGCCTCGGAAGAAACCAACCCCAGCAACACCTTGATTGCAGACTTCTGGCCTCCAGAACTGTGAAAAAATAAGTCTCTGT


TGTTTAATCCATGATACTTAATGACAGCCCTGGCTGACAAATACACTATTCAACCCATTACATGATAGGATGAGAAGAACCAAAATA


ACTCTAAGAGCATTTGTCTGCTATTCAAAGTTATTCATGGTGTTTTCTAGGAATGTGCTTATTTTAGTGAAACTATTTTAATAGATT


ATGTGGAGCCTGTAATGGTGGGTTTTCCTTCTTTCCTTCCTCATAGGTAACAGTATCGGGACCCTTACTGCACATGACAGGGATGAA


GAAAATACTGCCAACAGTTTTCTAAACTACAGGATTGTGGAGCAAACTCCCAAACTTCCCATGGATGGACTCTTCCTAATCCAAACC


TATGCTGGAATGTTACAGTTAGCTAAACAGTCCTTGAAGAAGCAAGATACTCCTCAGTACAACTTAACGATAGAGGTGTCTGACAAA


GGTTAGTATCATATCCACCGTCTTGAGTGCAAATCATTGTTTTCCTTCTAGCTATGAGTTATTTTCCTGCGCTAATGTCTGGTATGT


TATAGAATGATGCCATTTAAACATTCTTTGCTTCCTTTGTGAAACACACATAACACAGAGATAGCTGGTTGAACACTGTAAAGGCCG


GAGCTGCAGCTCAGGCACCATTGTTGTGTTGGTCTGGGTCCTATGGGAAGCAGATGCCAAAAGGAGATTAAATGTACGAGGATTTTA


TTGGGGGGAGCCCGTGAGAAAAAATTGCGGAAGGGCACAAAGAAGGCTGGGAGAGTCATCAGACCTAAATACAAGCCTGATGCCTGA


CGCTGGGTGAAGGGGAGATGGAGAAGGAAGGCTGGTGGGAATGTCCTAGACTAGGACAGTCTGAGGAAAGCTTGGCACAGCTGTCGG


GGAGTCTAAAGGGGGCTGTCAGAGGAATTCATTGTCTTTGAAAATGAGCTTTACAATTGCTGCTTTTCTCAGTCACTGGCTGTGTAC


AGTCCAGGGGAGTTGAGGTCTCAGTGTGAATGTGGTAATAGATTCCAGAGCACAGCAGTGGAGCTGTTGTCAATTAACAACCCTGTT


GTTGGAGGTCTGCCAGGCACATTCTGCAGAACATAATCACAAACAGGAAAATGAATTGTATTTCCCAATTCTTGCTTTCAGACTGAA


AGGACTCTACTGTAGGAAAGTGGAGGAGAAGAGCATCTTTCGGAAAGTTCTATCTTACCCTAACAGCTTCTAGTTGGCCGTTTGACA


GTATCAGGAGACATTCTTCCCCATACTCCTTATACAATTGCAGAGCAAGTGGTTCTTAATCTCTATTGGGTCACAGGAACCTTTGAG


AATCTGATAAAAACTATGCATTCTTAATCAACTGCACACATTGTTAAACAAATGTGCACAGACACACAAAATACCTGGATTCAAAGA


CAGACTCATTTCAAGGGCACTCAGACTCCTAGAAGGTCCTTTGAGTTAATGCGTACTAATCTTCGATTACCATATAATTCAGTAATT


GTTCTGCTGGCAGGCACGGATGACACAGGTATGGAGAACAAACAAGAAACGTTTCACACTGTGCTTCATGTTTCTGTCCTTTACAGG


GATATTGAGATACTAGGCAGAAGCCAGGTTTAGTAGGGCCCTAATGCGGAATGTTTGAAACCCAGTAATTTGACAAATATTAAGGCC


CTAATATTTGTCTAGCATTATTGTAAGAGATAGAACAGATGTAAGTATAATAAACCTTCCCTATTCATGACGAGCTAACAATTTCAC


ACTATCAACAGTCCATTCTTTCAGCAGTTATTCTGCATTTACCTATTTGAGGCACCATGCAAGGTACTGGGGAGACATAGATGATTC


TGTCCTCAAGGAGCACTCATTCTGGTAGAAGAGACGGACATGTGAGTCAGTAAATTGCAAGGAACTGCCCAAGGTAGCCCATGAAGG


AAATAAGTGACTCAGTGGAGGGAGAGAACAGGTACTGCTTTCTGGAAGAGGTATTTCTGAGCTGGGCTTTGAAGGATGAATATGACA


AGTTACAAAATCATGTAGGACTTATGGGAGAGTGGGAATCCATGTGGAAATACATGAGGACCTGGAGCAATTTGAAGATAGAGTTTA


AAGTGGGAATCAGATTACAAATTGTTTATTTGCATGAGTACGTCTATAGAAAATATGGACCAGATTATAAAATATATTAAAATACAT


GTGTGTGTTGATATAACTAAACATTCAACTGTGCACTACAGAAAACTAGAGACTAGGCTATAATTAACACAGTTTTACATAAAACCA


GGGAAGGCCTTTTACCCAGAAAGGCCCACTGCTGGTCAAACGAGGTGTGTGCAGAGCAGTGAGCCAGTGGGTTCTGGGTCTGGGACC


ACTCCAGTCTTCAGCCATTCTTGTTGTCTACAAACGTTCTGAGGACCAGCCTTAACTTCAATCAATATCCACTTGGTTGTAATTGGA


TTGTTAATAGATTCTGTCCCTGGGATCATGTCCAGTGCATTGAGCACCAGCTCTAGAGTTAAACTACCTGGGAATATTAGTCAGGAT


CCCAGCAGGAAGTGGAGACTCCCCTCAAAGAGTTGAAAGAAGGGATTGTTTGCAAAGGTTGTGGGCAGGGTTAAGGGAAACCAACAG


GAGGTGTGAAGCACAGTAAGCAGCATTTTCTGCCCTAAAACCTGAAGGAGCCAGGGAGGGGAGCATCCCCCAAAGGAGCAAGGCCTG


TGCCTGTCACTAGAAGAGGOCTGTTGGCAACGGGGGCGTGACACCCCCAGCTACACTCTTCCTGTCCTCCCTCCAGTCTCTTGCCAC


GCCTCTCAGTGGCAGAACCCAACTGTTACCCTCAGGGTGAGGATGTACATTGATGCAGTTCATAAGGTCAGCCCCTTGGGCTACAGA


GCACAGACAGAGGAATGGATGGTGGCTGCAGAGGGCAAAGGGAACCTCTGGGTTTGAATCCTGGCTCCATCACTAGTTAGTTGTGTG


ACCCTGGTTAGGTTACCTGAACTTCTCTATTCCCTGGCTTCCTCATCTGTTAATTAAATGGGAATGACAGTAGCACCTACAACATGA


AGTTATCATGAAGATGAATGAGTAACTCGGGTAAACAATACAGTTGCTGCTATATAGAGGCCGCTAACAACTGTATTATGATGAAAA


CATCTGTTCTGTTATTCACAGTTTACAGATAAATTGAGTGAGGCACCCAAGCTCTCACATACATGCTAAGTGGCAGACCCAGAGTCC


AAACAGTGAATTCCAAGCCCAGAGTCTTAACCATTATACAGTGCAGTGCACCATGGTTAGAACAACAGCAACCCAACAAAGAACCTG


TCATTTTATCTCTTGTTCTCTCTCCCCCAGGCATCCTGTCCCCACCTGCACTCCACACACATCTGGAATCTAGCTGAAGTGGCTGTG


TGCCTAGGTCTTGGAATTGTGAAACCCATCCCTGAAAGCCTGGGTGATTTCTCCAGGGTTCCAGGAGCTACCTCTGTCCCCACCTTG


CTTCCTGCAGGCTGGGTAGCCAGACTCTTGTGAACAGGCCAATGGTGGTAGTTCCTCCCTTATTTAGATAGAAGAGAGCAGGCCCTT


GGACCTCACCATCATAGTAGTCAGAGCAGATGTAGGTTGGATGTGTTCAGAGAAGGAGAGACAGCCACTGGGATGCTCACAGAAGGC


TTTCTGGAAGGACAGTTTTGCTCTGGACTTTGAAGATTACATAAGTTTCACTAGTCAGAAAAAGACTGCTTCACAAAAGGAAGCCAT


CCTGCTCAGGAACAAACCTTACCTAACTTTACTTAGGAGGACAGCAGGTGGACGGCAATGAAAAACCTAGAAAAATCTCTCTTAGAT


CTGTCTTTAGCCACCCTGCCCCACACTTGGTGACCACTTGGGTACAGGTGGGAAACAGAGAGCCCACTCTCTGCACAAATTGCATGT


CAATTGCAAAATTGTGCCTATGGCTGTCACTTCACTTGCCAAGTATTTTCTTGCAGATTTCTGATATTAATGCATGGTTTTCAGTGA


AAATTTCTATGACATATGACTTTGGTTTTCAGATTTCAAGACCCTTTGTTTTGTGCAAATCAACGTTATTGATATCAATGATCAGAT


CCCCATCTTTGAAAAATCAGATGTGAGTAGTTGTCATTATTTGTTTTTTCTTTACTTTATTCATTTTACTTCACCCTTTCTTCTGGG


ATAGAGACACAGACAGTAGCTAGGAAAAGTGCCAGACTTAACAGGTAACCTTGGTCAGTGCACAAATAACCCAGATGCCATCTTCAG


TGGAACTTTTTGGGGAACAATAACATTTACTATTACAGGTGTCTGGGAACATTCATTTATAAACTCCTGCCAATAGCTCATTTATTC


CAAGGGCTGCTTAAAAACAACAACCACAATCTTTGTCAAATTGAAAAAAGGTGAATGGCGGCTTACAGTTTGTCATTATATATTTTT


TTGTGTTAGGACAATAAATAGATTTACTGCTAGGTCTCAAGCATTTTTAGCCAAAAATTTAATATTTGGAATATTGGCGATTTAATT


TGTAATAATTGGGTAAGAGAAAGGGAGAAGAAAAAAATTAATCTCTGACTTAAGCCAAAGAAAAATGTGCCCAAGACATTTGAGAGA


ATTAGAACTGGACAGAAAGAAAAAAGTCAATTTAGAACCTCAAGAAAAATGCAAATTACTGTTTTCTTGTCATCGATAGGGCGTTCA


GACTTGGTGATGACTTTATCATTGTTTCCCTAAGGAGCGAAGTCTCTATTTTGAAGGAGCAAGAAGCCTATTTGACTAGACTGTTAT


GTTAATTTTTGAAGTCAGTTATGAGGCAGCCCAGAGCCCTGTGATGATGTTCATAAATCAAATAGGGACAAGCCTGCAACAAAGAAG


GGAATTGATTTATGAGGGGGCTAGGGGTGGGAAGAGGTGTGAGTGGATATGTCTTGTATAACAGGCACTGAGGTTCAGCAGGCATCA


AATAACCCATTTCTTCTCAGCCTCCATTCTCTTGGGCTTTTGATCCTTTCCTAACTTTGTGACCTCCTCGCCTTTTATCGAGACAGT


GTTTTTTAGATTGAGGGTAAGAATCCTGCACTTGAGGTCTCAGAGCTTAAATACTAATCTGGCTACAGAGAGTGAACCTGCTTGTTT


CAATGCTGTGGTCCTCTCTTCTGAGACCTACTTATAACCTTCTTTAGGATCATGATGCCAAGAGAGATAATCTGGGGGATTTTCAGT


GGAGTGGGAGATGGTCTAGGCCAGTGTTCAAGAGCATAGGCTTTGGAGTTGCACAAACATGGCTTTGAATCCCAATCCCTTTGACCC


ACTAGCTGTGTGACCCTTGGTGGGTTTTACTTCTCCAAGCCTTTGCTCCTCGTAAGTGGAGATGGTAACATAACTACTCCGTAAGGT


GTTTTGTTGATTTTCTTTATTGAGCACTTACTATGTGCCAAGAATTTAGGAGCTTTACATGCATTGTCTCCCTTAACACCCACAGCA


AACATGAAGTAGGTTCTATTACTATTGTCTCCATTGGACAGATGATGAAACTGACACTTAAAGAAGTGAAGTAACTTGCTTCAAGCC


ACTCAACTAATAAGAAGCAAGCCTACAATTCATATTCAGGCTGTTTAACTCCAAAGTTCAAGCTTTTAATCAACCTCTATTCATTGG


TTGATTTAAGAATTAATTAAATAATGTATATAAAGTGCCTACCACCTGATAGATACTCAATACATGGTGGCTATTTATATCATTACT


ACTACAATAATTAAGTTATTAAACAAATTGGATATGGGAGGGGGAATTTGTTTTAGAATCCTACCAGTAGCTCTCTGAGGTATTGCG


TTCTTTGGTACAATGGATATCAGCTCATGAGTATGACTGATGTTAAAATCAACTGCAATATATTCATCAATAGGAAAAAACATGCCC


CATGAAGATTGATGCAAACTATGACTTGTGTCTATTCTGAAACCAGAGAGATAAGTTTGTCCTTTGGCTTTGATGACAGCAGACCTT


CTCATTGTTTCCTTCTCCATTTTCTCCTTAGTATGGAAACCTGACTCTTGCTGAAGACACAAACATTGGGTCCACCATCTTAACCAT


CCAGGCCACTGATGCTGATGAGCCATTTACTGGGAGTTCTAAAATTCTGTATCATATCATAAAGGGAGACAGTGAGGGACGCCTGGG


GGTTGACACAGATCCCCATACCAACACCGGATATGTCATAATTAAAAAGGTAAATAGCCCATTTATTTAATAGAATTTGTCTTTGTT


TGTGGGTTAATTTACTAATGACAGTGTGAAGACCTATAAGCAGAGGTGATGTATTAGCAGCCATCTCTCAGGCATGGTGATGGGTTC


CTGGATTCCTGGATTCCTCTTAGTCGTTCCTGTCTTCCTGACAGACGGGAAGTCAGGATTCTAGACCTGGCTCTGTTGCTAGCTAGC


CAAGTAACTTTTGCAGGGAGGTAACGTCATATAAAATATATAAATTGCAGGATGAACAATTTTTTAGTATAAGTGTGTTCTATGCAA


TATTTGGGATGCACTTATACTAAAAACTTGTTTGTCATTTATCTGAACTTCAAATCGAACTTGGTGTTCTATGTTTTTATTTGCTAT


TTGCTAAATCTCGCAACACTCTTACGGTCTGGGAGTGGCACTCAGGGTCTCGCTTTCACTTCCCCCTTTGCAAATGTGAGGAGTTGG


GTTGGATGACCCCATGGGCCTTTTAGGCTGTAAACCCTTTATTCTAATGTGCCAGGCAGAGATACCTTTTGAATAATGCAACTGCTG


GGTCTCCTTCCAAGGTTTAATAGACAAGTGTCTTTTTAATCCCCCTCTCCGCTGCTTTACTTTCACCTTTTACTGTATTGCTAAGCC


CACGGGCTCTCATTCTGTCTCTCCCTCTGTAAGGACTGGATAATCTGGAGTCAAAGTCTTAATTACCTTGGTTCCTGTCTCTTTGTA


CAGGATTCTCCCAACCCTCCCTCAATCTACTCCTGTCCCCTGCCATGTATACCTGAATCTTGACTCTTTTCTCTGTGGCTGCCTCAT


CTGTGTTTAGAGCATGTCATGGGTTTACCAGATGACTCAATTGGAAGCAGCACTCAATGCCGTCCAATGTACTTACAGTTAAGATAC


TTTCCTAGGAAAGAGAGTGAAACCTCGCTGTTAAAAAGGGCCAGAGAGAATCTGCAAGGGTGGCTAATTGTTTAAGGTTTGCAGTGC


AGTGTGCTGGAAGCTGCAAAGGAAAGCTCTGGACTACAGTTTTGAGCCAGAATAAAAGAAAACTGAAAGAGGCTAAAAATGAAGACA


AAATAGAATAATTTCACAGAAAATGGACAGAAGCACAGAGAAAAAAGCACTAGTGCTGAAGCAAGCCCTAGGACAGAGCCTTGGAAT


TGTGATCCTACTGTTACCAAACATTCCAGCTTGAACCAAGGGCCCTGCTGCATTTCAGCAGAGAGGTTGCTGTGGACCAGCTCAAAG


CCTTAGCCTTGTGTGTGAGTCTGACATTTGGAAAAGGTACCATGACAACCTCCCCTTGTGCTCACAGCAGTCTGCATGGAGAGAGAA


TACCACAGAAAGAAAGGATAAAGGAAAGGGCAGTTTTCAGAGCTTGCAGTGGGTTGGTGTGTTCCTTTGCAGGTGACGGGGGCAGCT


TCCTTTTATCCTTTTGCAGGACCAGAGCTCTCTAGGAATCTAAGGGAAGATAGAGGCCCATCCATCCCAGTATGAACAAGGCCCGTA


TGTCATCTTTTTTTGAACAGCAGTTTAACTTGGCCATTTGTGGTTAATGGGCCCTTTTAGGGAGATGTTGGCACCTATCTCAATGAT


TAGCTGTGGGTGAGAGCTGTAAGTATCCTCCCTCACAACTTGACACGAGAGGTATGCTACAGTAGAGTAGGCCTCTGACCAAACTCT


TTGTCACATCCTTACTTTATATGTGGTTCTATTTCAAGTGTCTATTATGTCTCCTGGCATATATTAGAGGTTCAATAAATATTGCTT


GACTTAATGAATAAATGAATTCTGTCCCATATACAATTATGAACAAGCAGACACATAAGTGATCATCGAACCTGTGCTTTAGGCCTG


TGACATCCCAGCTCTCTGTCCCTTGGGCACTGTGATAACTGTCCTTGAGCAAGTGGATTTGTTCAACCATCCAGAGGCAGGTGATAA


CTGGCAGAACAGAACTGAGCCCTGGAACTCTGCAGGGTACAATCTGCTGGCCAGGCCAGATATCTATACTCCTGTTCACAATGACTA


AGGGATACACTATACTCGTAACCAAACAGCACATCTTTTTTTGAGACAGATGCAGTGCCGCAGTCATAGCTCATTGCAGCCTCAACC


TCTTGGGCTAGAGCAATCCTCCCACCTCAGCCTCCTAAGTAGCTGGGACCACAGGTGTGTGCCACCACACCCAGCTAATTTTTTATT


TTTGTAGAGATGGGGGTCTCCTTATGTTGCCCAGGCTGGTCTTGAACTCCTGGGCTCAAGTGATCCACCTGCCTCAGCCTCCCAAAT


TGCTGGGATCACAGGTGTTTGAGCCACTGTGCATGGCCCAAAGTGCATATCTTGGACACCACTCATATCACCAAGAAAATTTATTTG


TAAGATCACTTTGCTAATTAACAAACTTTCTAGTTCTAATTGAGATAGTGTTGGCTGAAGGACTATCATAGCTACCTCTGGGATATA


GATCTCGGATTAGGTTCTTTCAGATGCTAAGCAACAACCAACCCTGGGCTGTGGATTCTTGATTAGGACACACCAAATGTTAGCCAA


TTCCCCACTAGGATATAGAATAAAAATATAACAAATGTATGTAGCCATACTATTTGTTATTGAAGTGTTTTATAGACTATATAATTT


GGTTTTTTATGTATGGCTTTGTCTTCTAAGTCCTTGCCTATTAAGCCATCAAGGGACTACCACTGTTCTGAACCACTGTGTTAATAA


TTTTTAAAAGTTTAAGTTTGTTAATCACAATTATATCATTAACAGTTCATCTGAATTACATGTGCTAATCACAGGTAAAATTTTCAC


TGAGGGACTCATACGTGGCAACTATAGTTTGTTTGCATAAACTCTCTTGCTTCTCCCACTGATTCTGAGGGAGGCAGAAATTCAGGC


CCACAGCAAGGTACAGTCAGGCCTTCTGGTGATGGCAGAGCCGGGAACTTGACTCCAGGCCTCCACCTCCTCTCAGGAAATAATTTC


TGTGAGTCCTGGTGTTGCCACTTACTAGCTTGTGGCCTTGACCAAATGATGTAACCTCTCAGGCCCCAGTTTTCCAATCTGTAAAAA


TGGGTAAAATGGTAGCACCTTTCTAGTAAGGATGTTGAAGAATTAAATGCAAAAGTATGTGTATAGTTCCTAACACAGCATCCAGCA


GCTTGCAGACTTAAACACGTGGCATCACTTGATTCTAATTAATTAGAGCTAGGATTCTACCTGCGGACAGGTATGCTTTCCCCTGTT


GCCTAAGGGGGCCAAACTTGCCTAATTCAAGAGTCAGATGGTGCATACTGAGGACTGCGGCCTCAGCCTCTCAAGGGGAAAGCCTGG


AAATGAGTAATTTTGGCAAGTGCCCAAAGCAATCCTTCAGATTAAACAACTGTCAGAAATGCTCCCTGCTCTGTATTTACTTCTGCC


CAAGCTCCAGCCTCTCGTGTGCTTGGTTATCATGCTCTTGGGGCCAAACGTGTGTCATGAGCAGGAAAGCTATTTCTTTGAGCCCTG


CCTGGCTCAACAATAACTCTCCTGAGATCCTGTTTCTTGAAATTCAGGGTTCTGCCTTATTTTAACTTGCAAATTTTGTCACTTCTC


TACTATGGCTGATCCTTTTGAATTCTCAGTTCACTAGCTATTTTTAACCAGACCAAATGTCATCTGGAAAACTAATGTGCACACTTT


GATATCATCAGTGATCGCTAGTGAAAATTGTAAATATCCCAGTCTCAACCCCTCTCCTTCAGCATTTTCTTTGCCTCCAGGTTGAAT


CTAAATCTCTAGGTTTGACCTTTCAGGCGGTTTTGTGCACAAAAGGAATCGTGGTATGAGCAGGTTTTTTCAGTTAACTTGAATATG


TCTTGCCAGATGGGACTGAGGCCATTCCAAGAGGCAGTGACGGGTCTCTTGACTTGGCCTCACAGTCATATCCCCAGGTCATGAAAC


ACAATGCACGTGGCCGGACAAGGCTTGTTCTTGGCTCAGCTCTGCTTATTACCATGTGCTAATTTAGCATCTTCCGTTTATAATGAT


TTCTCCAGAAGATTTGGTTTGATGTTTTTCCAGGTGTGGAAGTTATGCGGATAGAATCCTCAATGGCAGGCTGCTGCTTTTCATTTG


TTCTTCCATCCAGTGTTTAGGGAACACTGACACTGCCTTCTAGCTAGTCTTCCCGCCCCAGTGTGGATCACCTCGAATCCATCCCCC


ATGTAGCTGCTCCTGGAGTTATCTTTCTAAGACACACATCTGACCTTGTTAGTCAAGGATGAAGTTCCAACTCCTCAGCTCGCCGTA


CAGTCTTGTCTTTCCACTGTCAGCCTTGCACGTTCTCTTCTGGTAATACAGGCTGCTTCTCATTTGCACACACAGTGTCTCATTTCT


TTAAACCATTCCCTCTGGGGCCACAGTGATGGGATGAGGAAAAGCCAGGGAGGGTGCTTAGGACCTGCTTGGTGGTGAGGATGGATG


CATGTGCTCTGTCTGAGCATATGGACAACTGTGCTGCCTGCCTGGGCCCGGACTTTGCTGGACTGGATAGGAACAGAGAGCTGTGTC


CTTTGTCCCCATCACAGGCTCATTCTGGGGGCTGCTGCCTTCCTGCTTCGTCTACTAGGCTTTTATCTCAACTGCACAGTTCTGTCA


TCCCCTGAGACTGGGAGTGGGTCCTGTGAGTGAGAAACTCCAGCTTGTTCTCCCCACCTCTACTTCAGGGGGAGAAGCCCTAATTGA


ACCGTGGACCACGTGACGTGTATTGGACCACGTCACGAGGTCGACGAGGGCCAGGCCCTGCAGACAGTGGGTGCTTATCACTATGAA


CAACCTCTTTTTTCACACTTAGCTGGCTTACATGATTTTATCTCTTATATATTTGAACAAATTTCAATTGATTCTTCTTTCTCAACC


CCGAGTCTTCACACACAGTTCCCACCCTTCTACGTGAAAAATTGTCCCACAGCACTTATGAACTAGAGAGTGAGTCATGATGGTGTG


TGTTGGTGCATGCATGCGGGAAAGGGGATTCTGGAAGGTGGGGATCTTCTCCAGAATCTCCTCTCCATGGAGGCCCTCAAGGACCAG


GCCTTCCTGGTCTTTGTAGTTCCTGACCAGCCCACTGTGGGCACTATGTGTCAGGGAACAGATGAGAAGCAAAGATGAATATGATGC


AGTTCTTCTTCTCATGGAGCTTAGGGTCAGTGAAGATCTAAAATACATCAACACTTAGATCTATTAGGTGCTATGAGACTGCACAGG


ATGTGCAGCTTGTCAGTTTGAGGATGGAATGTAGGGATCAGGAAGCCGACACGGAGAAGACAGCAGTAAGCCCACTCCTGAAGAGGG


GGAGTACTCTTGGGTAGCCCTGTTAAATTCTGCCTCATATTAAACCAAAATTGGTTTCTTGATGTTCATTCCTGGTTCCATCTGGCA


TGTCCTCAGCAGATCATCTGTCATCTCTGTTTCCCTTTCCCATCCTCCATGAGTTTAAAATCTTTGATTTGGGGGCTTGAGTTTTGA


GGCCCTTGGAAAATCATTTCCCATAAAAAATGGAAATCTCTATGTAAGCATTTCTCAAGCTGTCACCTGAGAATGTCTTGGGAGAAT


CAATACATTTCTGTTGAATAATGAAGTGTCCCACAGTTAATTTAAATTTGAGGACTTCCGTGTTCCAGTTCCTCTTCTAAGACATAT


TAGCGTAGTGCAAGCTCTGGTAAGACCTGCAGAAAAGACTCTTTCATGGCTCTGTAATCATTCTGAGAAGGTTTTTGCTGACACTCG


ATTGAGAACCACTGCTATGAAAGTTTGTCTTGTTTATAATTGACAAAAATTGTATAGGAGGACAACATGTTTTGAAATATACATACA


TTGTAGAATGACTAATTAGAGCTAACTAGCATCTGAATTACCTCACTTATCATTTTTTGTGATGAAAACACTTAAGATCTACTCTTC


TGTGATTTTAAAGTATACACTATATTGTTGTTAACTATAGTACCACGTTGTAAAATAGATATTTTAAACTCATTCCTTCTAACTGAA


ATTTTGCATGCTTTTACCAGCACCTCCCCAATCTCCTCATGCCCCAGCTCCTGGTAACCAACATTCTACTCTCCAAGTTCAACACCT


TTAGATTCCACATACAAGTGAGAACATGTGGTATTTGTCTTTTCATGCCTGGCTTATTTCACTTACCGTAATATCTTCTAGGTTCAT


CCGTGTTATCACAAATGATGGAACTTCCTTCCTTTTTAAAGCTGAACAGTATTTCATTGTGTGTGTGTATATATATATGTGTGTGCG


TGTGTATGTATGTGTATGTATGCATATATATACTGCATTTTGTTTATCCAGTTGTTTGTTGTTCGACACTTAGGCTGATTCCATGTC


TTGGCTATTGTGAATGATGCTGCAGGGAACATAGGAGTGCAGATATCTCTTTGACATACTGACTTTATATACCCAGTAGTGGGATTT


CTGGATCGTATGGTAGTTCTATTTTTAATTGTTTGAGTTTCCTCCATACTGTTTTCCACAATGGCTATTGTAATTTACATTCTTACC


AACAGTGTACAGGGTTCCCTTTTCTCCACATCCTCACCAATGTTTGTTTTTTGTCTTTTTGATAAGTCATTCTAACAGGTGTGAGGT


AATATCTCATTGGGGTTTTAATTTGCATTTCTCTGATGATTAGTAATGAGCATTTTTTTCCATATACTTGTTCGCTATTTGTATGTC


TTCTTTTGAGAAATGACTATTCAGGTCCTTTGCCTAGGTTTTAAACAGGTTGTTTTCTTGCTACTGAGTTGTTTGAGTTCCTTATAA


ATTTTTTATATTAATCCTTTTTCTAATGTGTATTTGCAAATATTTTCTCCTGATCTGTAAGTTGCTGCTTCACTGTTTCCTTTGCTA


TGTAGAAGCTTCTTAGTTTGATGCAATCCCATTTGTCTATTTTTGCTTTTGTAGTCTGTCTTTTTGGGGTCACACCTAAAAGATCAT


TGCTAGGCTGGGCATAGTGGCTCACGCCTATAATCCCAGCATTTTGGGAGGCTGAGGTGGGTGGGTCACTTGAGGTCAGGAATTTGA


GACCAGCCTGGCCAACATGGCAAAACCCCCTTCTCTACTAAAAATAAAAGGGTGAGTTTCCTCTATCTCGTGAGATGGTTTGCCCTT


CTGTCATAGGATAACACAGCACAAAGTCCTCAACAGATGCTGGTGCCATGTTCTTAGGCTTTCCAGCCTCTAGAACTGAGAGTCAGA


TAAACTTCTATTCCAGCCAGGCATGGTGGCTCATACCTGTAATCCCAGCCCTTTGGGAGGCCAAGGTGGGCAGATCACTTGAGGTAA


GGAATTTGTGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTATTAAAAATACAAAAATTAGCTGGGTGTGGTGGTGGGTGCCTA


TAATCCCAGCCACTTGGGAGACTGAGGCAGGAGAATCACTTGAACAAACCTGGGAGGCGGAGCTTGCAGTGAGCCAAGATTGCGCCA


CTGCACTCAAGGCTCAAGGCTGGGTGACAGAGCATGAGGCTCCATCTCAAAAATAAAAAATAATAAAAAAAGATCATTGCCAAGACC


AATGTCAGAGTTTTCTTCTATGTTTTATTCTAGTGGTGTTATAGTTTCAGGTCTTATATTTTGTCTGTAATCTATTTTTAACGGATT


TTCATATATGGTATGAAATAGTCTAATTTCATTCTCCCACATGTGGATATCCAGTTTTTCCAATATTATATATCGAATATATGAGAG


TTTAAGAAGGATAGGGAATGAATCTTTTAAGGGAGCTAATCACCCCAAAATTAATTTTCTCTCTTTCTCCTACACAGCCTCTTGATT


TTGAAACAGCAGCTGTTTCCAACATTGTGTTCAAAGCAGAAAATCCTGAGCCTCTAGTGTTTGGTGTGAAGTACAATGCAAGTTCTT


TTGCCAAGTTCACGCTTATTGTGACAGATGTGAATGAAGCACCTCAATTTTCCCAACACGTATTCCAAGCGAAAGTCAGTGAGGATG


TAGCTATAGGCCTAAAAGTGGGCAATGTGACTGCCAAGGATCCAGAAGGTCTGGACATAAGGTAAAGGGCAACAGTGCTGGGCAGGC


CTGGCTGCGTGGTCACCAAAGCCAATGGGGAGGAGGAGGAGCTGGCCTGCACTGACTCCAGGGCTGACCCTCACAGCATACCCAGCA


ATGATGAAATTGGCTTTGGTTTAGGAAGCTGTCAACACCCTGGGGGCATTCCAAGGGATGGTGGTTCATCAATAACCATCTAGGCTC


AGACAAGTGGGAAGCAGCATGAGGTTCCATTCCAGCCCATGAGCTTCAGGTCCCAGCTGAGAGCTGGATGGTTCAGGAAGTGAGGTT


CACCTCTGAGACACTAGAATAACCAGGCCCTGTGTCTAAGCCTGTTATCTAGGCTAGGGTTTAGGAAAGGGTTCCAGCCCTAAAGGT


GTATTGGAGTTCTAGACAGAGACCAAAGCCCAATTGGACAGACCATGCCAACTTACAGGGCTGAGGGAATCTTCTGGATGTAGGATA


CATAGGTTCCTTGGCTCCAAAGAGCTGATCTAGGGCACCCCTGGAGAAGCTGGTGCTCTGGCTGAGGTGGCTAAACAAAATGTGTAA


ATATTTCCATCTTAGCAATTCCTTTTTTTCAGTTCAGTAAGACCCACACAGATTTGCCTTAAAAAGTACAATGATGATTAACTTAAG


AAATATATGTTTGTATATATCTGTATAATATCTATAAAATCTTTAAGATCATGTAGTTAAGACTTGAACTCAGATCTTTCGCTGCTG


TTGTACATTACACCTCCTGTCTATGGCTAGGAATATTTCAGCATGACTTAATCACGCGTGTGGCTATGAATCGCAGAAAACAATTCC


TTAAGTTTCTCTAAACATCTGGAGGGAGTCTTGCCTCCCATTGAGCTGTCCTTCAGGCACTTGGATTCACTTCTAAGACCTTTATCT


GATCATTGAGAAGCAAAGTTACCACCTGCAGTTTTACTCTAACTACTTCTGTAGTTTTACAGAGAAGAAAGAACAGTAGGGGATATA


CTGTATGGTTTAGTGTAGATACTACTGGGTCAAAAATTATGAGAAGACACAAAATGTTTTTAATCTTTATACCATTTATTTAACAAA


AGTTCCTATCTTCTTCATGAAAATGCTATAAAAACCATTGGTCAAAGACGTGAATAAAAAGTTTATCAGTGGGAAAAATAAAGGCAT


GTAAGAAAATTACTGTGATGAAACAAGGAAAGGATACATATACCATTAAGTTGAGGTCAGGAAGAGGAGGTTAGCAAGGGAGACTGA


GAAGAGGTGTTCTGTAAGGTACAATTCCAGAAGACAAATGAAGAAAGTGTTTCAGGAGTAAGGAATAATCAATAGTTCAGACATGAG


TAATAAGTCTGTTAAGAATTAAGGATGACTCCAGTGTTGGTCTGAGTAATTTAATTCTCCAGCTCCACAAACTTAAAATCTGTTAGC


ACCCAATGGATTTGAATCCAATCCTTCAGCAAATATTATAGATTCTTTTATTGAAATATATTCAGAATCCACCTGCTTCTCCCTGCT


TCCAGCCTGCTCCAAGGCACCACCATGTCTGTTCTGGATTCGTCCTTGCCCCTGCCGTCCCCCACCCCACTCTGAATCTACTCACTG


AATTGCAGTCAGTGACCTTTTAAAAAAGTCAATCAGATCATCTGACTCCTCTTTCAAAACCCTCCAAAGCATTCCATCTCTTTCAGG


ATGAAATCCCAAGTATAAAGGGTTTCATACTCATTACCCATGTATATAACCTAACACAGTGTTTGGCATATGGAATATACTAAAAAA


ATACATTGTGGGAAATTAACACATCATACTTTTTTAATGATTCTCTTGTCCTTTGATATGTAGGTTGCTTCCAGTATTTTTTATTAT


AGAAAATGTTTTAAATAGATGTATGCATGTAATTCTTTTTAAACTTTGATTAAATTGGGTTTTTTTAGGTAGCATTTCCAGGAGTGA


AATTATTTGGTCTAAAGATATGGACATCCTCATGACTATGATGTGTTGCTTTTTAAAGGACTACCATTGGTTTTCCTGTGGTTCTAG


TCTTGTCTGTCTCAACTTCATCTTCCAAACACCTACCAATGAGCTCCGTTGAAAGCACAAATATGGCCAGGTCACCTTCTTGCTTAA


ATCATTGGCTGGCTGCCCATTGCTTCTTGTGATCTGGCTCTTCAAATCTCTGTGGCTTCACCTTTTGCCACCTTCTGCTTCCCAAGT


ATACCCCAGCACTGCTGAAATGCCTGACCCCACACTCACCATGCTGTTCCTTGGCCCTTGGTGCTTTATCTCACACTCTTCCTTCTA


CTTGAAGCGTCTTCTTCTTGCCTTAAACATCTACTACTTCAGAAAGACTTTGCTGATTCCTGTAAACTTCTCTTGGATTCCATAGGG


CCCCCTCTGTTGTGTTTACCACATTTTATTGGAATCAACTGTTTATCTGTCTATCTCACTTGCCTAAGAACACCTTTTTGTGATCTC


TTCCCTTGGCCCACTGCCTGATCTTCCTCAGCACTCAATAGATGTTTGTTGGATGAGGAATTCACTGTGTTACCAGGGTCTATGAGT


ATCCACCCATCTCGCCCAACGTTTCCACCACTGGGTGTTCAAATTTTCTAGGTGGGTGGTTTGCTAAGAGGTTTTAAAAGATACTTC


CAGGTTACTTTAATTTGAGTTTTTGATTGCCAGAAAAGTTTAACTACTTTCCCCAGAAGTTGTGAACTATACCCTTCCTAATACAAG


CACAAACACCACATTGTAAGGATGAACAAATCCTTTTGAAGACAGATGAAATGCAAATAAAGCATTAATAATATGAGATAATAGATC


CTTTAATATGTTTTAAATAATATACAAGTAATGCTGATAATGATAATCTCAGCATTATCATTTGTATATTATTTACAACAATATTTC


AAGGATGCACAAACATATTTAGTTGACGCACAAACTAGCTTCACATTTTCATGCAAAGTAATGCAGGCTTTCTTTTGCTCTTTTCAT


TTGATGAAGCTATTCACTGAGGGGAGACACAAGAGGTTGGCTTAAAATTGACCACGTGACTGGTGAGATCTTTAGTGTGGCTCCATT


ACACAGATTATCAGAAGATACATGGGTTGAAATGGGAGGGAGGATAAGAAAACTGACAGGGCCAAAACACCAGAATATCACAACCTT


AAAGTGGAAGGATCAGAAGGGTACAAAATATAAGGGAGTGCTCATATCTTCCTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGATGG


AGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCGATCTCCACTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCCT


ACCTCAGCCTTCCGAGTAGCTGGGATTACAGGCACCCACCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCAC


CATGTTGGCCAGCCTGGTCTCAAACTTCCGACCTCAGGTGATCTGCCTGCCTCCACCTCCCAAAGTGCTGGGATTACAGGTGTGAGC


CACCACGCCCAGCCCCTTTGTGGTTTTGTTAAAGGTGAAAAACACCTGTGCCCCCAGCAGGGCTGCTGCTCACTCTGTGGTTTCCTG


TAGGGGCTATGGCCTCTTCTAGAGAGTTCTGTGTCCCTGGCTGAACTACCTCCCTTCTTCCAATGTGGTTGTGGGTTTCCCCCAGGA


GCTCTGAGTGGAATCAAACCACTGACCTGTTCACGTAGACCACCACTTGCTCCTTCAGCCTTAAATTGTAACTCTCATCCTTTTTGA


AGCAGAAAATGTTTTATGAAATGTTCTCTACTTTGATGTGTGTGAGAATCCCCGGGGAGCTTGTTGAATAACACTAGGAGTCCACCC


CTGGAGTTTCTGATTCCATAGGTTTGGGTGAACAAGGGGTATCTGTGTTTTGACGAAATCAGGTGAACTTTTGAAAGGAAAGACAGA


AAAGCCCAGGATGTTTGAGCCATTCCTGTGTAATCTTTGTATCTTATTTATTTTAGTTGTGCTGATATATATTGCCTGCTGGCTCCA


ACTGTGGAGTTCCAGAGAACTTTTTTAAAATAAAAATAAACACATAGGAATAGTATGTTTACCCAATAATAAGCCTGGCAACTAAAA


AAGAGTTTCTTTGCATTTTCATGGAATTTTCAGACATACAAGTAGGAAATCTGTTGATCCAATGTTGACCAGTCTCTAATTAGCTAG


TAAATGTATCTGGCAGGTTTACCAAAAAAGAGAATTAAACAAATTACTCAATAAATATGTTTTTAGACTCCCCCACCACAGCCCCGG


AAAAAAACTTTCAAAATGTGAGGGCCAGGGTTGAGAGCTGAATTGGAGAAGAGAGACAGGAATCATAAAAACGGCCCCTGCATGTGG


AAAGATTAAGAAAAACAAAATTACTTCAGTCAAGTCAAACCAAAAAGGGTAGAATGCAGAACGGTGTGCCAGCTTGGGAGGGGTGTG


TGTGAATGGACAGGCCCTCTGCTTCTGTCTCTTGCTTGAGTGCAGCACATTCCACTATCACATTGTATACATTTAACTCTTGATTTA


AAACCTCCCAGTGAAGCAGCAGGCAGGTTCTGGCTGAGCCTTTATGCTGTGCACACCCCTTTCTCATACCATGGGGATCAGAACTTC


ACTCTGGATGTGTCCCAAGAGTTTCTCACATTCTAGAAGTTTCAGAAATCAAAACCAGGGTCCAAAACCCTGTTCTGTTTTTAGTTT


CTGGCACTGACATGATATAAATAGATACAATAACTTCGAGAACACAGTGGCCTTTTCTTCTTTGGTTAAGTATAGCCATGGACATAG


ACGATGTTGAGAAGAAAATCAAGAAAACAGGGTTTACTGGAAATGAGCAAGAAAACATTACTGGAATCAAACAAGGTCAGAGTCAGA


AGTTGTAGAAACAATGTCTGTGATTGGTGTTGAGGAGGACATGATAACAGTCAGTGTTTATGTTGCACTGACAGCCCCATACTGAGC


ACTTAGTGTAATAACTTACTCCTCATACAACACTATAACGTAGGTGCTATTATTGACCACATACTGTGAACAAGGAAACCAAAGCAC


TGAGAAATTAAGTAACTTGCCCAAGATTACATAGCTACCAACCAGTTATGCTGCAGATCCAAGTTTTTTACTCCTATCATATAGTAA


ATAATGTCTGTGGAGCCTTTTACTATTTTCCAGAACATTCACTCATATGTGGGATTCTTGCAAAGCCACACAGCTGAAGAAAATAAG


CTTAGAAAACTCTACTAACATGCCTAAGGCCTGCTAAAGAGCAAGTGAAGGTGTGAGTGCTAGAGTTAGACCTCTTGGATTGAAAAC


CTCTCTGCCTTGGGCAAGTTACACAACTTCTGAGCTCAGTTTTCACAATTATTTTGAAGTAATATATGTAAAATATTAGCACATATC


TCTTAGTTATTATTATGATGGTCAGTAAGACTTTTTCACCAGTAATGAAACTAGGTCTTTGATTCTAAAAGCTTGTCGTCTTTCTAG


CATCTCAGTGTACCTAACTCCTTGAATTTTAAAGAAAGGGAAATCTTTCTTATTAAGAGGAAAATGAGTGAACTGATCCCATGTTTC


ATCATTCAATTCCTTAGGGGGGTCTTCCTTGAGCTCTGTGTCAGAGTTCCACCTGATCCTTATGGATGTGAATGACAACCCTCCCAA


GGCTAGCCAAGGACTACACGGGCTTGTTCTTCTGCCATCCCCTCAGTGCACCTGGAAGTCTCATTTTCGAGGCTACTGATGATGATC


AGCACTTATTTCGGGGTCCCCATTTTACATTTTCCCTCGGCAGTGGAAGCTTACAAAACGACTGGGAAGTTTCCAAAATCAATGGTG


AGTTGTCAGAAATACATGGAAAAAAACATAGATGGATGATGAAAGTAGGTTTTATTTAACTTGGTGGGTTTGCTGTACTCAGCAAAG


AGCTTTCTTTCATGCTTCAGGAAGGAAGTTCATGCTTTGGAAGCTTGTACAGGGAAGGACTCCAGAGGGGAAAAAGCCCCAGGATTT


CAAGGGAGGAAAGATTATGACCACACAGCATTCTCTTGGTGTAGATGAACAGTTGGATGACCTAAGCATCATTTGCAAAATTTTCAA


TGACAGATGGAAAGCAGATTTTATACAAATTTTTAAAAACTTTGAGATAGATATATATATTCAAAGTATACAATTTTATGAGAATTG


ATTACATGTAAATACCACTGAAGCCATCAGCACAATCAAGACAATGAACATTTCCACCACCTCCAGAAGATATTTCATGCCCTATTA


TAATCTCTGCTTCCCACCCATCCCCTCTCCCCAGGCAACCATTGAAGTGCTTTCCATTACTATAGTTTTCATTTTCAATAATTTCAT


CTAAATAGAATAGTATAGTATGTATATTTTTTTTGGTCTGGCTTCTTTCATCTCAGTATTTTGAGATGTATCGGTGTTGTTACATGC


ATCAGTACTTCATTCCTGATTATTGAGGGGTAGTATTCCATTGAATGACTATACCTGTTCACCTGTTGATTGTAACTCCAACTTTTG


CTATTACAAAGCTGCTGTGAGGATTTGTGAACAAATATTTTGTAGGGACAAAGATTTGCAGTTTTCTTGGTTAAATACTGAGGAGTG


GAATGGCTGGGTCATATGGGAGTTATATGATTCAGTTGTTAAGGAAAGGTTGAACTACTTTCCAAATTGTTCTTAACATTTTACATT


CCCACCAGTGTGTGAGAGGTCCAGTTGCTCAGCATTCTCCCAGCACTTGCTGTGCTCAGCCTCTTTAATTTTAGCCATTCCAGTGGG


CGTGGAGTAGTATCTCATAATGGTTTTATTTGTATTTCTCTAATGACTAGCGGTGTTGAGCATCTTTTCATATGCAATTTGCCATCC


ATCTTCACTGGTGAAGTGTCTTGTTAGATATTCATTTTTTAAAAATTAGGCTGTTTGGATTCTATTGCTGAGTTGCAAGCATTTTTA


ATATACATAGATGATGTGCTTTGTTAGATATATATCTTTTGTAAATATTTTCTCCCAGGCCATGGCTTGTCTTTTCATTTTGCAAGT


CTTTTAAAGAGCAAATTTAAAAATTTTGGTATCTATTTTTTTCATGTTTTATTCATGATTTGTATGTTGTGATGCTTAAATTTTTGC


CAAACTTAGGGTCCCTAAAGTTTTCTGTTTTTTTCATTTCCCAAATTTTATAGTTTTAGCTTTTGCATTTAGCTCTATGCCTTTTTA


AGGTAATTTTTGTATAGGCATACCTCATCTTATTGCACTTTGCTTTATCGTGCCCAATGGATCTTCCATTTTTTTATAAAATGAAGG


TTTGTGGCAACAAAGTCTCTTGGTGCCATTTTTCCAACAGCATGTGCTCACTTTGTATGTCTGTCACATTTAGGTAATTCTTAAACT


TTTTCATTATTATATCTGTTATGCTGATCAGTGATCTTTGATGTTATTATTATAATTATTTTGGGACACCCGGAGCCATACTCACAT


AAGACGACAAACTTAATCTGTCAATGCGACGTCGACGTACGTTCTGACGCTCCACAGACTGGCTGTTTCCCCATGTCTCTCTCTCTC


CTTGGGCCTCCCTATTGCCTGAGACACAATATTGAAAATTAGGCCATTAATAACCTTAAAATGGCATGTAAGTGTTCAGGTGAAAGG


AAGAGTCACACATCTCTCACTTTAAATCAAAAGTTAGACGTGATTTAGCTTAGTGAGGATGTTATGTTGATAGCCAAGATTGGCCAA


AAACTAGGCCTCTTGCATGAAATGCTTAGCCAAGTTGTGAAGGCAAAAGTTATTGAGGGAAATTAAAAGTGAACCTACAGTGAACAC


AAATAATAAAAAAGCAAAATAGCCTTATTGCCATTAAGGGAGAAAGTTTGAGTGGTCTGGATAGAAGATTAAAACAGCAACAATAGT


CCTTTAAACCAAAATCTAACCTAGAACAAGGCCTTAACTCTTCAATTCTGTAAAGGCTGACAGAGGTGAGGAAACTGCAGAATAAGT


TTGAAGCTAGCAGAGGTTGATTTATGATGTTTAAGGAAAGAAGCTATTTCCATAACAAAGTGCAAAGTGATGCAGCAAATTGATGCA


GAAGCAAGTAATCCAGAAGATCTGAGATCCTTAATGAAAGTGGCTACACTAAACAAGCTTTTCAATGTAGATGAAACAGCCTTCTTT


TGGGAGACAATGCCATCTTAGACATCCATAGCTAGAGAAGTAAATGCCTGGCTTCAAAGCCTCAAAGGACAGGCTGGCTCTTGTTAG


GGCTAATGCAGCTGGTGACTTTAAGTTAAAGCCAACCCTAATTTAGCATTCCTAAAATACTAGGGTCCTTAAGAATTATGCTAAATC


TACTTTGTCTGTGCTCTGTCAATGGAACAACAAAGCCCAGATGACAGCACATCTGTTTACAGCATAGTTTACTGAATACTTTAAGGC


CACTGTTGAGACCTACTGTCCCCCAAAAAAGATTCCTCTCAACATATTACTGCTCATTGACAATGCACCTGGTTACTCAAGAGCTCT


GGTGGAGATGTACAAGGAAATGAATGTTGTTTTCATGCCTGCTAACACAGCATCCATTCTGCAGGCCCCAGATCAAGGAGTAATTCT


GACTTTCAAATTATTTAAGATATACATTTCATCAGGTTATAGCTGCTATTAGATAGTAATTCCTCTGATGGATCTGGGCAAAGTAAA


TTGAAAACCTTCTGGAAATGATTCACCAGTTTAGATATCATCAAGAACATTTGTGATTCATGGGAGGAGGTTGAAATATACACATTA


GTAGGAGTTTGGAAGAAATTGATTCCAACCCTCATGGATGACTTTGAGGGGTTCAAGACTTCAGTGGAGGAATCACTGAAAACGTGG


TGAAAATAACAATAGAGCTCGAATTAGAAGTGGAGCCTTGATGATGTAACTGAATTGCTGCACTCTCATGATCAAACTGGAATGAAT


GAGAGTTGCTTCTTACAACTGAACAATGTGTTTTGTTTGTTTGTTTGTTTTTGAACAATGGAATCTGCTTCTGGTGAAGATGCCATG


AACATTGTTGAAATAACAAGCAAGGATTTAGAATATTCCATAAACATAGTTGATAAAACAGTGGCAGTGTTTGAGAAGACTTACTCC


AATTTTTGAGAGATGTTGTCTTGTGGGTAAAATGCCATCAACCAGCATCACATGCTATACAGAGGGCTCTCTCATGAAAGGAAGAGT


CAATAAGTGCAACAAACTTCATTGTTGTCTTATTTTCAGAAATTGCCACAGCCATCCCAGCCTTCAGCAACCACCAACATTGAGACA


GGAAATGATTTGCAGCAAAAAGATTATGACTCATTGAAGGGTCAGATAATCATTAGCATTTTTTGGCAACAAAGTACTTTTAAATTA


AGGTATGGACATTTAGGGGTTTTTTATTTTTAGGTATAATGCTATTAACAGTCTAGAGTATAGTATAAGCTGTTATTTCAGTAGAAA


AACAAAAAATCTGTGTGACTTGCTTCACTGAGCTATTTGCTTTATTGCAGTGGTCTGGAACCAAACCCATATCGCTGAGATATGCTT


GCATAGGGGGTGTGGTAAAGACCAAAGTTTATTGTTTTTAACATAGCTATCTAACTGTTCTAACACCATTTGTTTAAAACATCCTTT


TTTTACATTGAATTATCTTAACAACTTTGGCAAAAATCAAGTGACCACCTATACATAAATCTATTTCTGAATTTTTCTGTTTCATCA


ATCTGTTTCTATTTTTATACCAATAACACATTGTCTTGATTGCTGTAGCTGTATAAGGCTTGAAATCAGGTAGATTAATTTTTCCGA


CTTTGTTCTTTTTCAAAATTCCTTCATTCTATGTCTTTTTCATTTCTGTATAAATTTTAGAATGTAGCCTGTTCCTTTCTACCAAAA


AAATCCTGTTGAGATTGTATTGAATCTACTGGGGAATCTGGAGGAGAATTGATATATTAAGTCTTCCAATTCATGAACATGGTATAT


GTCTCCATTTATTTAGCTCTTTAATTTCGTTCAGCAATGTGTTTTAGTTTTCAGTGTATAGTTCTTACAAAATTTTCCCTAAGCATT


TCATATTTTTGATATTTTAAATATTTCAATTTCTAAATATTTCTAGATATAGGAATATAATGATTTCTGTATACTGATCTGTATTCT


AGAGGCTTGCTGACCTTATTTAGATTTCATAGATTTTCTACATAGACAATCATGTTGTCTGTGAATAATGACTTCTTCCTTTTCAGT


CTGTATGCCTTTTGTTTATTACTGGCTGAAACCTTCAGTGAAATGTCAAATAGAGCTAGTAAGAGCAGAAATACTTGACTTGTTCAT


GATCTTAGGAAGAAAGCATTTAGCCTTTCACCATTAAATATGATGTTAGCTGTAGGTTTTTTATTGTAGGTCGTCTTTATTAGATTT


AGGACTTTGCCTTTTATTCCTATTTGTGAGGGTTTTTTTTTTTCCTAAATTGGAAATGGATATTAAATTTTTCAAGTGCTTTTTCTC


CATGTATTGACTATGTGGCTGATTTGATTTTTTGGGCCTATTAATTGATGCATTATTATCAACTTTTGAATCTAAAAATCACCTTAT


TCCTGGGATAAAGCCTACTTAGTGATGAAATATTACCATGTTTATGTATTGTTGGATTTGCTAAAACTTAATTTTTGCATCTATATT


CATGAGGGATGTTGGTCTCTCTCTATATTTTGCCTTGTATAATGAGGAAGCATTCCACCTCTTTATCTTCAATTATCTGGACAAGTT


TGCATAAAATTGGTATTACTTCTTCTTAAAGTTTGAAAGAATTTGCCAGTAAAGCTATCTGGGCCTGGTGTATTTTCTTTTTAAGAA


GTTTTAACTACAAATTCAATTTTATAGATATAGAAAAATTCAATTTATATATTTCTTTTTGGTTGAGCTTGTACCTTTCAAATAATT


CATCTATTTCATTAATCTAATGTATTGATATAGTTCATATTTTATTAATATCTGTAGAATATGTAGTGATATCACCTCATTCTGATA


TTGGCAAATTATCTTTTTTCCTGATAATCTGGCTAGAAGTTTTATTGATATTTTCAAAGAACCAGCTTTTGGTTTCATTGATTTTTT


TTCTGTTTTTGTTTTATATTTCACTGGCTAGATCTTTATTGTTTCCTTTATTCTTCCTACACTGTGTTTTTGTTCGTGTTCTGTTTT


CATTAAGGTGGAAGCTGATGCCATTAATTTGAGATCTTTTTGTTAAACAGGCATTTAGAGCTATAAATTTATCTTAGGTGTCACATT


AGCTGCATTTTTTTTTTAATAGACAGGGCCTCAGTCACCCAGGCTCCAGTGCAGTGGTGTGATCATGGCTTACTGCAGCCTTGAATT


CCTGGGCTCAGACGATCCTCCTGCTTCAGCCTCCCAAGTAGCTGGGACAACACGTATGAGCTACCACACTTGGCTAATTTTTTATTT


TTAAATTTTTTGTAGAGATGGGGGTCACACTATGTTGCTCTGGCTTGTCTCAAACTCCTGGGTTCAAGTGAGCCTCCCACCTCAGCC


TCCCAAAATGCTGGGATTACAGGTGTGAACCACCATGCCAGGCCCACAAAATTTGATACATTGTGTTTTCCCTTTAGATTTCTTTTG


TGATTATGTGTTATTTAGAAGTGTGTTATTTAGTTTCCAAATATTCTGGGAATATTTCCTATACCTTATACCTTTCTAACTTCTAAT


TTAATTACATCATAACCAGAAAACATGACTAGAATACTTTTAAATTTATTTAGACATTTTTTCTTTCAGTACTTTGAAGGTATTTCA


CCACCCCCCCTTTTTTTTTATTTTTTTTTTATTTTTTGGAGACAGTCTTACTCTGTTGCCCAGGCTGGAGTGCAGTGGCACAATCTC


AGCCTCCCAGGTTCAAATGATTCTTGTGCCTCAGTCTCCCTAGTAGCTGGGATTACAGGTGCACACCATGATGCCCAGCTACTTTTT


GTATTTTTAGTAGAGACAGGGTTTTTCCATGTTGGCCAGACTGGTCTCAAACTCCTGGCTTCAAGTAATCTGCCTGCCCCAGCCTCC


CAAAGTGCTGGGATTATAGGCATGAGCCACCGGGGGTGCCCTGCCCACTATGGTTCTTCCTTGTTCCATTGAATGTTTGTATTCTTT


TTTCTCTGGGTGCTTTTAAGATATTCTCTTATTACTTTTAAGTAATTTGATGTTCATATTGCCTTGATGGCATTTTATTCATTTTTC


TTATTCCTGAAGTTTGATGATCATCTTGGATCTGAGGATTTGGAGTTTTCATCTAACATGGAAAAAATATTAGCCATTGTCTTATCA


AAAATGTTTTTCTCTCCACTATCTTTCTTGGCTTTCAGGAATTCGATTACACATGTATTAGGCCACTTGAAGTTGTCTCAAAGCTTA


TTTTTTTTCTATTTCTTTTTGGATAGCTTTATTTCTATATCTTCAAGTTTACTGTTTTTTCCTGCTATATTCAATGGCTATATTATA


GCCATTCATCCAACCTAGTCTATTTTTATATCAAACTTTGTAGTTTTCTTCTATAAATTAACTTGGGTTTTTAAAATGTTCTGTATC


TATCTACACTTCTCAGTCTTGTAGCTTCTTGAACATATAGAATATAATTATAACTGTTTTCATGTCTTTTCCCACTATTTATGTAAT


ATGTATAATTTCTGGGTAGGCGTCAATTGATCTTTTCTCTCATAGGTCATATTTTTCTCTTTTACTGAATGTCTGGCAATTTTTTAT


TAAATGCCAGACATTTAGATGCTGAATATTTTGTATTCCCATAAATATTCTTGAACTTTATTGTGAAATACAGTTAGATCATTTGGA


AAAAGTTTGATGCTTTCATGTGTTGCTTTTAAATTTTCTTAGATAGGGCCAGGGCAGCATTTATTCTAGGGCTAATGTTTTCAAACT


TGTGAGGTGAAGCCTTCTATGTATTCTACCTGGTAGCACATGAATTATGAGATTTTTAGCTCTAGGGACCAGGAATGATTCCTGGCT


CTTTGTGAGCGCTGTGTTCTCTAATCTTTTTAGGTGGTTCTTTCCCCAGCCTTGAGTAGTTCCTTCATATAAATACACTGATCAGTA


CTCAGCTAAAGCCTTAAGAGACCCCTCTATAAATCTCTTTAGTGTGCATTCTCTTTGCAGCTCTCTCTGGGACTCTGCTCTGTAAAC


TCTAGTTTCTTAACTTTGCCTTACTCCTGTGCTCCATCACCTCAACTCAGGGACATCACTGGGCTCTGTCTGAGCTCCTGCTCCCTG


CAACTGATACCTGGATATTTGCTTTGGGTGGTAAGCTGAGGCAATTATAAAATTTACCTCATTTGCTTTCCTTCTTTCAGAAATCAC


TGTCCATTGCCTAATATATAAATCTTTAAACCCATGGTTTCACATATTTTTTGTTCTTTTAGTTGTTTTTGGTGGAATGGTAAATCT


GGTCCCTGTTACTATATCTTATCTAGGTGGGCCATAATAATTTTTAAATATGCATATTTAAATCTTCCCAAATTTGGGAAAATTTCT


TGGCAGATATGAATAGGGAGGGCATAAGTGTGAATTGTAGCAAAATCAAATTTTTGTTTAGAAATTTGAAGTTTAGTGTTTTTGTAC


TCTCAATTTTCTATTTTAAAAAAGGTGGTAAATGCCCTGAAAACCAGGTATAATATCATCCATACCCTTATTTCTGGACTCAGAGGG


ATTTTGAGGCCTATAAATGTTATGACTTACCCAATTACATAGCTAACAAGCAGCAGATTTGAAACCCAGAATCAGGTCTACAGAAGC


TCAGTCCCAGGTACTCTCCAATCTTCTGACACATACAGTCGATCCCCATTATTTGCAGATTGTGTTTATAAAATAATCTACATGATA


AAATTTGTAACCCAAAAGTCAGTACTTACAGGAGCTTTCGCTTTTGCTTTCATGGACACTGGCAGGGTGGTGAAAAATACTGGACAC


ACATATTCCCAGCTCTCACATTGTTAAGTTAGTTAGGTTTTTTTTTACTTTTTGCAGTTTATGTAGTGCCCTGTTTTTCACGTTTCT


GTGCTTTTCATTGGTGATTTCATTGTTTAAAATGGCTCTGAACTGGGTGGGGTGTCGCCTCACCTAGGAAGCACAAGGGTGAGGTGA


TTTCCCTTTCCTAGTCAAGGGAAGCCATGACAGACTGTACCTGGAAAAACAGGACACTCCCACCCAAATACTGCACTTTTTCCAAGA


TCTTAGCAACTGGCAGAGAAGGAGATTCTCTCCCGTGCCTGGCTTGGCAGGTCCCGTGCCCACAGAGCCTTGTTCACTGTTAGCACA


GCAGTCTGAGATCAAATTGCAAGGTGGCAGCCTGGCTAGGAGAGGGGCATCCACCATTCCTGAGGCTTCAGTAGGTAAAGCGGCTGG


GAAGCTCAAATGGGGTGGAGGCTACAGCAGCTCAACAAGGCCTACTCCCTCTATAGACTCCATTTCTATGGACAGGGCATAGCTCAA


CAAAAGGTAGCAGATAACTTCTGCAGACTTAAACATCCCTGTCTGACAGCTCTGGAGAGAGCAGCGGTTCTCCCAGCATGGCATTTC


ACCTCTGAGAACAGACACACTGCCTCCTCAAGTGGGTCCCAAACCCCCATGTAGCCTAATTGGGAGACACCTCCCAGTAGGGGCTGA


CTGATACTTCATATAGGTGGGTAGCACTCTGGGACAAAGCTCCCAGAGGAAGGATCAGGCAGCAATATTTGCTGTTCTGCAATATTT


GCTGTTCTGCAGCCTCCACTGGTGATACCCAGGCAAACAGGGTCTGGAGTGGACCTCCAGCAAACTCCAACAGACCTGCAGCTGAGG


GACCTGTTAGAAGGAAAACTAACAAACAGAAAGGAATAGCATCAACATCAGCAAAAAGGACATCTACACCAAAACCCCAACTGTAGG


TCACCAACATCAAAGACCAAAGGTGGAGAGAAACCAGAGCAGAAAAGCTGAAAATTCTAAAAACCAGAATGCCTCTTCTCCTCCAAA


GGATTGCAGCTCCTTGCCAGCAACGGAACAAAGCTGGATGGAGAATGACTTTGACGAGTTGACAGAAGCAGGCTTCAGAAGGTTGGT


AATAACAAACTTCTCTGAGCTAAAGGAGCACATTTGAACCCAACGCAAGGAAGCTAAAAACCTTGAAAAAGGGTTAGATGAATGGCT


AACTAGAATAAACAGTGTAGAGAAGACCTTAAATGACCTGATAGAGCTGAAAACCATGGCAGGAGAACTTCGTGATGCATGCACAAG


CTTCAGTAGCTGATTCAATCAAGTGGAAGAAAGTGTATCAGTGATTGAAGATCAAATTAATGAAATAAAGCAAGGAGAAAAAAAGAG


TAAAAAGAAACAAAGCCTCCAAGAAATATGGGACTATGTGAAAAGACCAAATCTATGTCTAATTGGTGTACCTGAAAGTGACGGGGA


GAATGAAACCAAGTTGGAAAACACTCTTCAGGATATTATCCAGGAGAACTTCCCCAATCTAGCAAGGCAGGCCAACATTCAAATTCA


GGAAATACAGAGACCACCACAAAGATACTCCTCGAGAAGAGCAACCCCAAGACACATAATTGTCAGATTCACCAAGGTTGAAATGAA


GGGAAAAATGTTAAGGGCAGCCAGAGAGAAAGGTCGGGTTACCCACAAAGGGAAGCCCATCAGACTAACAGTGGATCTCTCTACAGA


AACCCTACAAGCCAGAAGAGAGTGGGGGCCAATATTCAACGTTCTTAAAGAAAAGAATTTACAACCCAGAATTTCATATCCAGCCAA


ACTAAGCTTCATAAGTGAAGGAGAAATAAAATCCTTTACAGACAAGCAAATGCTGAGAGATTTTGTCACCACCAGGCCTGCCTTACA


AGAGCTCTTGAACGAAGCACTAAACATGGAAAGGAACAACCAGTACCAGCCACTGCAAAAACATGCCAAATTGTAAAGACCATCGAT


GCTAGGAAGAAACTATATCAATTAACAGGCAAAATAACCAGCTAACATCATAATGACAGGATCAAATTCACACATAACAATATTAAC


CTTAAATGTAAATGGGCTAAATGCCCCAATTAAAAGACACAGACTGGCAAATTGGATAAAGAGTCAAGACCCATCAGTGTGCTGTTG


GGAGACCCATCTCACGTGCAGAGAAACACATAGACTCAAAATAAAAGGATGGAGGAAGATCTACCAAGCAAATGGAAAGCAAAAAAA


GCAGGGATCGCAATCCTAGTCTCTGATAAAACAGACTTTAAACCAACAAAGATGAAAAGAGACAAAGGAGGCCATTACATAATGGTA


AAGGGATCAATTCAACAAGAAGAGCTAACTATCCTAAATATATATGCACCTAATACAGGAGCACCCAGATTCATAAAGCAAGTCCTT


AGAGACCTACAAAGACTTAGACTCCCACACAATAATCATGGGAGACTTTAACACCCCACTGTCAATATTAGACATATCAATGAGACA


GAAGGTTAACAAGGATATCCAGGACTTGAACTCAGCTCTGCACCAATCAGACCTAATAGACATCTACAGAACTCTCCACCCCAAATC


AACAGAATATACATTCTTCTCAGTGCCACATAGCACTTATGCCAAAATTGACCATATAATTGGAAGTTAAGCACTCCTCAGCAAATG


TAAAAGAACAGAAATCACAACAAACTGTCTCTCAGACCACAGTGCAATCAAATTAGAACTCAGGACAAAAACTCACTCAAAACCACA


CAACTACATGGAAACTGAACAAGCTGCTCCTGAATGACTACTGGATAAATAACGAAATGAAGGCAGAAAATAAAGATGTTTTTTGAA


ACCAATGAGAACAAACACACAACGTACCAGAATCTCTGGGACACATTTAAAGCAGTGTGTAGAGGGAAATTTATAGCATTAAATGCC


CACATGAGAAAGCAGGAAAGATCTAAAATTGACACCCTAACATCACAATGAAAAGAACTAGAGAAGAAAGAGCAAACACATTCAAAA


GCTAGCAGAAGGCAGGAAATAACTAAGATCAGAACAGAACTGAAGGAGATGATAGAGACACAAAAAACCCCTCAAAAAAACAATGAA


TCCAGGAGCTGGTTTTTTGAAAAGATCAACAAAATTGATAGACTGCTAGCAAGACTAATAAAGAAGAAAAGAGAGAAGAATCAAATA


GACGCAATAAAAAAATGATAAAGGGAATATCACCACTGGTCCCACAGAAATACAAACTACAATCAGAGAATACTATAAACACCTCTA


CACAAATAAACTAGAAAATCTAGAAGAAATGGATAAATTCCTGGACACATACACCCTTCCCAAGACTGAACCAGGAAGAAGTTGAAT


CTCTGAATAGACCAATAACAGGCTCTGAAATTGAGGCAATAATTAATAGCCTACCAACAAAAAAAAGTCCAGGATCAGATGGATTCA


CAGCTGAATTCTACCAGAGGTACAAGAAGAGCTGGTATCATTCCTTCTGAAACTATTCCAATCAATAGAAAAAGAGGGAATCCTCCC


TAACTCATTTTATGAGGCCAGCTTCATCCTGATGCCAAAGTCTGGCAGAGACACAACAAAAACAGAGAATTTTAGACCAGTATCCTT


GATGAACATCGATGTGAAAATCCTCAGTAAAATACTGGCAAACTGAATCCAGCAGCACATCAAAAAGCTTATCCAACACAATCAAGT


TGGCTTCATCCCTGGGATGCAAGGCTGGTTCAACATACACAAATCAATAAACATAATCCATCACATAAGAAAAACCAATGACAAAAA


TCACATGATTATCTCAATAGATGCAGAAAAGGCCTTTGACAAAATTCAGCCCTTCATGCTAAAAACTCTCAATAAAGTAGGTATTGA


TGGAACATATCTCAAAATAATAAGAGCTATTTATGATAAACCCACAGCCAATATCATATTGAATGGGTAAAAACTGGAAGTCTTCTC


TTTGAAACCGGAGAAGACAAGGATGCCCTCTCTCACCACTCCTATTCAACACAGTGTTGGAAAAGTTCTGGCCAGGGCAATCAGGCA


AGAGAAAGAAATAAAGGGTATTCAATTAGGAAAAGAGGAAGTCAAATTGTCCCTGTTTGCACATGACATGATTGTATATTTAGAAAA


CCCTATTGTCTCAGCCCAAAATCTCCTTAAGCTGATAAGCAACTTCAGCAAAATCTCAGGGTACAAAATCAATGTGCAAAAATTACA


AGCGTTCCTATACACCAAAACAAAGAGAGCCAAAACATGAGTGAAGTCCCATTCACAATTGCTGCAAAGAGAATAAAATACCTAGGA


ATCCAACTTACAAGGGATGTGAAGGACCTCTTCAAGGAGAACTATAAACCACTGCTCAACGAAGTAACGGAGGACACAAACAAATGG


AAGAACATTCCATGCTCGTGGACAGGAAGAATCAATGTCGTGAAAATGGCCATACTGCCCAAGGTAATTCATAGATTCAATGCCATC


CCCTTCAAGCTACCAATGACCTTCTTCACAGAATTAGAAAAAACTGTAAAGTTCATATGGAACCAAAAAACAGCCCGCATTGCCAAG


ACAATCCTAAGCAAAAAGAACAATGCTGGAGGTGTCACACTACCTGACTTCAAACTATACTACAAGGCTACAGTAACCAAAACAGCA


TGGTACTGGTACCAAAACAGATATATAGACCAATGGAACAGAACAGAGACCTCAGAAATAACACCACACATGTACAATCATGTGATC


TTTGACAAACCGGAGAAAAACAAGCAATGGGGAAAGGATTCCCTATTTAATAAATGGTGCTGGGAAAACTGGCTAGGCATATGTAGA


AAGCTGAAACTGGATCCATTCCTTACACCTTACACAAAAATTAATTCAAGATGGATTAAAGACTTAAATGTTAGACCTAAAACCATA


AAATCCCTAGAAGAAAACCTAGGCAATACCATTCAGAAGACAGGCGTGGGCAAGGACTTCATGACTAAAACACCAAAAGCAATGGCA


ACAAAAGACAAACTTGACAAATGGGATCTAATTAAACTAAAGAGCTTCTGCACAGCAAAAGAAACTACCATCAGAGTGAACAGGCAA


CATACAGAATGGAAGAACATTTCTGCAATCTACCCATCTGACAAGGGCTAATATCCAGAATCTACAAAGAACTCAAACAAATTTAAC


AAGAAAAAAACGACCCCATCAAAAAGTGGGCAACAGATATGAACAGACACTTCTCAAAAGACATTTATGCAGCTAACAGACACATCA


ACATGATCATCACTGGTCATCAGAGAAATGCAAATCAAAACCACAATGAGATACCATCTCACACCAGTTAGAAGGGTGATCATTAAA


AAGTCAGGAAACAACAGTTGCAGGAGAGGATGTGGAGAAATAGGAACACTTTTACACTGTTGGTGGGAGTGTAAATTAGTTCAACCA


TTGTGGAAGACAGTGTGGTGATTCCTCAAGGATACAGAACCTGAAAGACCATTTGACCCAGCAATTCCATTACTGGGTATATACCCA


AAGGATTATAAACCATGCTACTATAAAGACACATGCACACGTATGTTTATTGTGGCACTATTCACAAGAGCAAAGACTTGGAACCAA


CCAAAATGTCCATCAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATATTATGCAGCCATAAAAAAGGATGAG


TCCATGTCCTTTGCAGGGACATGGATGAAGCTGGAAACCATCATTCTCAGCAAACTATCACAAGGACATAACACCAAACACTGCATG


TTCTCACTCATAGGTGGGAATTGAACAATGAGAACACTTGGTCACAGGGCGGGGAACATCACACACCAGAGCCTGTCAGGGGGTGGG


GGTCTGGGGGAGGATAGCATTAGGACAAATACCTAATGTAAATGACGAGTTGATGAGTACAGCAAATCAACATGACACATGTATACC


TACGTATCAAACCTGCACATTAAGTTCTAGGGTACATGTGCACAAAGTATTAAAAAAAACCACACAGGGTCAAACCTAAAAGATGAC


CCATGATAAAAAAAAAAATGGCTTTGAACTATAGTGCTGAAGTGCTATCTAGAATTCCTAAGCACAGGAAGGCTGTGATGTGTGCCT


TACAGGGAAAAATTGTGGTTTGGGACACAAATTAAAAGTAATGTCCAAAACTGCGATTATTTTCCACCAACCTAAATATGTGTGTTT


GATAAGCTTTGTTCAGGAAGTTCTAGTGCTGTTAGATGTGAGTTAAATGTTAGAATGAACAATATATGTTAAATAAGATATCTTTGA


ACAGCAACACACAAAAAGCAAGGTTATGTATTGATCAGTTGGGGAAAATATGACTAGAAGCTCACAGAAACCTAACCCTGTCTTTCC


TCTAGGAGCAATGGTTCAGCATTCATTAATTCAGTGTTTGGGGCAACTTTATAGAGCATAAGTGCTACAAATGATAATTGACTATAT


TTAGTATAAATTTCTACAGAGAAATCATGAATTAAGAACTTAAAGGATGCTTTAGCCCTTTCTTACCTTATGGGAAGATACATGTGG


AATGATGTGGATGATACTTTGGGCAGTTTAACTCATATCTAGCCATGTTCCAGTCAACCTTAGTATGTGATACAAAATGAGCTTTAT


TCCTGCTAATCCAGGGTCTGAAGTTGTATTTTCATTTTTTTTTCCTGTCCTGGCAGGTACTCATGCCCGACTGTCTACCAGCCACAC


AGACTTTGAGGAGAGGGCGTATGTCGTCTTGATCCGCATCAATGATGGGGGTCGGCCACCCTTGGAAGGCATTGTTTCTTTACCAGG


TAGATATTCTGCTATAGGCAACTCAGGCTAGTATCTGTCACCATGGGCCGTTTGAGGAGATTCTTGTCTTTGATATGGGATTCTGCA


ACTATTCACTTGAGAATTTATCCTACCAAATACTGTCCTGCTTTTCAGTTACATTCTGCAGTTGTGTGGAAGGAAGTTGTTTCCGGC


CAGCAGGTCACCAGACTGGGATACCCACTGTGGGCATGGCAGTTGGTATACTGCTGACCACCCTTCTGGTGATTGGTGAGTGTAATT


TCTTAATTCAAAGAGTCTTATCCTGGGCCTCAGAAATGTGAGCTCATCTCAGGGCCTGTCTTCCTGGACTGGTCTGGTGGCTGCTCA


AATGGCAACTCAGGCAATAGCCCAGAAGGTAGATCACCAGCAAATTACATCAGACTTTCTTGATTGGAGTTACAGCTTTAGTACTAC


CCTCTGTCTCTATTGCCTTATTAGTTTAGAAATATAAGGGGCTTTATGGTCATCAATTGTCATATATTATGCCTAGTTACAAAGCTT


TTGTGATAAAGAGGGAAGAAATGCAGTAGCTGTGCCATGTGTCAGGCACTGTGCTTGATGGGGAAAGAGTGACATACACAGATCCTA


CACCAGAGTTTATGGTCTCACCTGCCATTGTTGTTACAGGCAGAAGTTAGCCTTCCAGTGGCGATGCTGAGATACCTGAAATGTGTA


GTGCAGAACTTCCCTATGCATAGAACCCTGATTCTTTACTACCCAGAATAACCCATTGCATCATGACCACAGCCTCTGCCATAGCCC


CTAGCTTGGCTAGACAGTACAGTCCCCTGATCTAGCTGTCTTTTTCTTTTTTGCAAACAACTCAGTGCCTATTCCAAGTGTTTCCTT


ACCCAAAATGCTTGAGAGCAGAAGTGTTTCAGATTTTGGGTTTTTTCCAGATTTTTGAACATTTGCAAATACACGATGAGATATCTT


GGGGATGAGACCCAAGTCTCAACACAAAATTCACGTGATTCATAAACATTTTATACACGTAGTCTGAAGGTATTTCATACAATATTT


TAAATAATATTGTGTATGAAACAAAGTTTTGCCTGCAACCTGTCACATGAGGTCAGGTGTAGAATTTTATGCTTGTGACATCAAGTT


GGTACCCCAAAAGTTTCAGATTTGAGATTTTCAGATTAAGGATACTCAACCTATATAGTAATTGCCCTCTTTCAACTGTTGTCCCCA


CCACAAGTTAAACATTAGGAATAGATACTTCATTATTTCATGTGTACCTGAGTGAAGGGGTTTATGGTTTCATATCCTTTTTCTTTT


AAAAGAAGGACTAGGATTATTCTAAGTATTATTGATTGTTCTCTCAGCATCTGATCTTTTCTCCCATGATCCAGTGTGTCACACTGG


ACTCTGATTCATGCATCTAAAGGGGGTCTCACTTCTTTATACCCTTCAGTCTGGACTCCCTATGGCATGGGAGGGCCTTCATGTCAT


GGCCACTTCCCATCCTAATGTGTGCATGGTGATCATCTTTCCTCCCTGAGAACCACTATCTACTGCACACTTTTCATGGTAATTGAG


CTGTCTTTTTGAGGTCCCACTCACTTACATAGGTCCCTTCTGCCTCTGTGCCTTTTCTTATTCTATTTGCCCTCCCACCTTGAAAGG


ATTTTTGAATTTACAAATCAGATAGCAATTTTCTTAACGTATCAATTTAATTCCATAATCTTACCACAAGTTAAAGACTGCTTGAGT


TTGGGGACATCCAGAAATAGAAGTAATAGGATTTTACAGTTTCATGACCTTATTTTCAAGATAGGGTTGGAATTATAAGTTTCTGAG


CATCCAGACTTTTCTGCCATGATTCCTCCTATAAACTTACTAGCAGGTTAATTTCCTTAAAACAACTCCTTCTTCATAGTGGACTCT


GACAGTACACAATCAGTGCTGAGCTGCACAGTGTAATTTTGATGTATCAGGTGGGAGAAACCAAGAAGGTTAAGTAGTCTACCCAGG


GTCCCACAACAACATAGGCAGGATCCAGGAGGAAGGCGCCCAAGGAAATGCGATAGTTGGTATGGACACGATGAAAATCAGCTTCAG


GGAGGTGAACAGGTCAGAGAACAGCTTTCTAGTTGTGCTAATTGGATTGTTTTCTCTAGGAAAGGGGAAGAATAGAATCAATATTAA


GTATATATAAAGTTCAGGAACTTTGTCAGGTGCTTATACACTCTATAGTGTGGGACATATACACTCCATAGTGTGGAACATTAGGTC


CTATATTCTTACAGCGAGATCCAGTGAGAGCCACCAAGTCAGCTATGATTTGGGACTTGATACATACATACAACAGGATAAATGATA


AGCTCATTTCTCCAAGAAGGCCAACGACTAGAGTCCCTTATTCACTAGGACAGTGAAATTTTGTTGAATCACATACAAAAATGAAGT


TGAGTCATTTTTTTCCTACCACAATACTACTTTATAACTGAATGTGACAGTACATTTTAAAAGGTCCCATTTATTTGACCCTGGGTT


TTTTCTTTTAGGTATAATTTTAGCAGTTGTGTTTATCCGCATAAAGAAGGATAAAGGCAAAGATAATGTTGAAAGTGCTCAAGCATC


TGAAGTCAAACCTCTGAGAAGCTGAATTTGAAAAGGAATGTTTGAATTTATATAGCAAGTGCTATTTCAGCAACAACCATCTCATCC


TATTACTTTTCATCTAACGTGCATTATAATTTTTTAAACAGATATTCCCTCTTGTCCTTTAATATTTGCTAAATATTTCTTTTTTGA


GGTGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTACAGTGGTGTGATCCCAGCTCACTGCAACCTCCGCCTCCTGGGTTCACATGATT


CTCCTGCCTCAGCTTCCTAAGTAGCTGGGTTTACAGGCACCCACCACCATGCCCAGCTAATTTTTGTATTTTTAATAGAGACGGGGT


TTCGCCATTTGGCCAGGCTGGTCTTGAACTCCTGACGTCAAGTGATCTGCCTGCCTTGGTCTCCCAATACAGGCATGAACCACTGCA


CCCACCTACTTAGATATTTCATGTGCTATAGACATTAGAGAGATTTTTCATTTTTCCATGACATTTTTCCTCTCTGCAAATGGCTTA


GCTACTTGTGTTTTTCCCTTTTGGGGCAAGACAGACTCATTAAATATTCTGTACATTTTTTCTTTATCAAGGAGATATATCAGTGTT


GTCTCATAGAACTGCCTGGATTCCATTTATGTTTTTTCTGATTCCATCCTGTGTCCCCTTCATCCTTGACTCCTTTGGTATTTCACT


GAATTTCAAACATTTGTCAGAGAAGAAAAACGTGAGGACTCAGGAAAAATAAATAAATAAAAGAACAGCCTTTTCCCTTAGTATTAA


CAGAAATGTTTCTGTGTCATTAACCATCTTTAATCAATGTGACATGTTGCTCTTTGGCTGAAATTCTTCAACTTGGAAATGACACAG


ACCCACAGAAGGTGTTCAAACACAACCTACTCTGCAAACCTTGGTAAAGGAACCAGTCAGCTGGCCAGATTTCCTCACTACCTGCCA


TGCATACATGCTGCGCATGTTTTCTTCATTCGTATGTTAGTAAAGTTTTGGTTATTATATATTTAACATGTGGAAGAAAACAAGACA


TGAAAAGAGTGGTGACAAATCAAGAATAAACACTGGTTGTAGTCAGTTTTGTTTGTTGATCCGCTCTGCCTCTGTTTTTATTTGTGG


AGGGGAAGGACAGAATAACAATTGTTATTTTTTGTGTATAAAAATTGCCTCCCCAGCAGCCCTAGTCAGGGGCTTATAGATAAAACT


CCCATCTC





HUMAN mRNA SEQUENCE hR28-010.1 (Seq ID No: 61)


GGAAGAGGGAGTGTTCCCGGGGGAGATACTCCAGTCGTAGCAAGAGTCTCGACCACTGAATGGAAGAAAAGGACTTTTAACCACCAT


TTTGTGACTTACAGAAAGGAATTTGAATAAAGAAAACTATGATACTTCAGGCCCATCTTCACTCCCTGTGTCTTCTTATGCTTTATT


TGGCAACTGGATATGGCCAAGAGGGGAAGTTTAGTGGACCCCTGAAACCCATGACATTTTCTATTTATGAAGGCCAAGAACCGAGTC


AAATTATATTCCAGTTTAAGGCCAATCCTCCTGCTGTGACTTTTGAACTAACTGGGGAGACAGACAACATATTTGTGATAGAACGGG


AGGGACTTCTGTATTACAACAGAGCCTTGGACAGGGAAACAAGATCTACTCACAATCTCCAGGTTGCAGCCCTGGACGCTAATGGAA


TTATAGTGGAGGGTCCAGTCCCTATCACCATAGAAGTGAAGGACATCAACGACAATCGACCCACGTTTCTCCAGTCAAAGTACGAAG


GCTCAGTAAGGCAGAACTCTCGCCCAGGAAAGCCCTTCTTGTATGTCAATGCCACAGACCTGGATGATCCGGCCACTCCCAATGGCC


AGCTTTATTACCAGATTGTCATCCAGCTTCCCATGATCAACAATGTCATGTACTTTCAGATCAACAACAAAACGGGAGCCATCTCTC


TTACCCGAGAGGGATCTCAGGAATTGAATCCTGCTAAGAATCCTTCCTATAATCTGGTGATCTCAGTGAAGGACATGGGAGGCCAGA


GTGAGAATTCCTTCAGTGATACCACATCTGTGGATATCATAGTGACAGAGAATATTTGGAAAGCACCAAAACCTGTGGAGATGGTGG


AAAACTCAACTGATCCTCACCCCATCAAAATCACTCAGCTGCGGTGGAATGATCCCGGTGCACAATATTCCTTAGTTGACAAAGAGA


AGCTGCCAAGATTCCCATTTTCAATTGACCAGGAAGGAGATATTTACGTGACTCAGCCCTTGGACCGAGAAGAAAAGGATGCATATG


TTTTTTATGCAGTTGCAAAGGATGAGTACGGAAAACCACTTTCATATCCGCTGGAAATTCATGTAAAAGTTAAAGATATTAATGATA


ATCCACCTACATGTCCGTCACCAGTAACCGTATTTGAGGTCCAGGAGAATGAACGACTGGGTAACAGTATCGGGACCCTTACTGCAC


ATGACAGGGATGAAGAAAATACTGCCAACAGTTTTCTAAACTACAGGATTGTGGAGCAAACTCCCAAACTTCCCATGGATGGACTCT


TCCTAATCCAAACCTATGCTGGAATGTTACAGTTAGCTAAACAGTCCTTGAAGAAGCAAGATACTCCTCAGTACAACTTAACGATAG


AGGTGTCTGACAAAGATTTCAAGACCCTTTGTTTTGTGCAAATCAACGTTATTGATATCAATGATCAGATCCCCATCTTTGAAAAAT


CAGATTATGGAAACCTGACTCTTGCTGAAGACACAAACATTGGGTCCACCATCTTAACCATCCAGGCCACTGATGCTGATGAGCCAT


TTACTGGGAGTTCTAAAATTCTGTATCATATCATAAAGGGAGACAGTGAGGGACGCCTGGGGGTTGACACAGATCCCCATACCAACA


CCGGATATGTCATAATTAAAAAGCCTCTTGATTTTGAAACACCAGCTGTTTCCAACATTGTGTTCAAAGCAGAAAATCCTGAGCCTC


TAGTGTTTGGTGTGAAGTACAATGCAAGTTCTTTTGCCAAGTTCACGCTTATTGTGACAGATGTGAATGAAGCACCTCAATTTTCCC


AACACGTATTCCAAGCGAAAGTCAGTGAGGATGTAGCTATAGGCACTAAAGTGGGCAATGTGACTGCCAAGGATCCAGAAGGTCTGG


ACATAAGCTATTCACTGAGGGGAGACACAAGAGGTTGGCTTAAAATTGACCACGTGACTGGTGAGATCTTTAGTGTGGCTCCATTGG


ACAGAGAAGCCGGAAGTCCATATCGGGTACAAGTGGTGGCCACAGAAGTAGGGGGGTCTTCCTTGAGCTCTGTGTCAGAGTTCCACC


TGATCCTTATGGATGTGAATGACAACCCTCCCAGGCTAGCCAAGGACTACACGGGCTTGTTCTTCTGCCATCCCCTCAGTGCACCTG


GAAGTCTCATTTTCGAGGCTACTGATGATGATCAGCACTTATTTCGGGGTCCCCATTTTACATTTTCCCTCGGCAGTGGAAGCTTAC


AAAACGACTGGGAAGTTTCCAAAATCAATCGTACTCATGCCCGACTGTCTACCAGGCACACAGACTTTGAGGACAGGGCGTATGTCG


TCTTGATCCGCATCAATGATGGGGGTCGGCCACCCTTGGAAGGCATTGTTTCTTTACCAGTTACATTCTGCAGTTGTGTGGAAGGAA


GTTGTTTCCGGCCAGCAGGTCACCAGACTGGGATACCCACTGTGGGCATGGCAGTTGGTATACTGCTGACCACCCTTCTGGTGATTG


GTATAATTTTAGCAGTTGTGTTTATCCGCATAAAGAAGGATAAAGCCAAAGATAATGTTGAAAGTGCTCAAGCATCTGAAGTCAAAC


CTCTGAGAAGCTGAATTTGAAAAGGAATGTTTGAATTTATATAGCAAGTGCTATTTCAGCAACAACCATCTCATCCTATTACTTTTC


ATCTAACGTGCATTATAATTTTTTAAACAGATATTCCCTCTTGTCCTTTAATATTTGCTAAATATTTCTTTTTTGAGGTGGAGTCTT


GCTCTGTCGCCCAGGCTGGAGTACAGTGGTGTGATCCCAGCTCACTGCAACCTCCGCCTCCTGGGTTCACATGATTCTCCTGCCTCA


GCTTCCTAAGTAGCTGGGTTTACAGGCACCCACCACCATGCCCAGCTAATTTTTGTATTTTTAATAGAGACGGGGTTTCGCCATTTG


GCCAGGCTGGTCTTGAACTCCTGACGTCAAGTGATCTGCCTGCCTTGGTCTCCCAATACAGGCATGAACCACTGCACCCACCTACTT


AGATATTTCATGTGCTATAGACATTAGAGAGATTTTTCATTTTTCCATGACATTTTTCCTCTCTGCAAATGCCTTAGCTACTTGTGT


TTTTCCCTTTTGGGGCAAGACAGACTCATTAAATATTCTGTACATTTTTTCTTTATCAAGGAGATATATCAGTGTTGTCTCATAGAA


CTGCCTGGATTCCATTTATGTTTTTTCTGATTCCATCCTGTGTCCCCTTCATCCTTGACTCCTTTGGTATTTCACTGAATTTCAAAC


ATTTGTCAGAGAAGAAAAACGTGAGGACTCAGGAAAAATAAATAAATAAAAGAACAGCCTTTTCCCTTAGTATTAACAGAAATGTTT


CTGTGTCATTAACCATCTTTAATCAATGTGACATGTTGCTCTTTGGCTGAAATTCTTCAACTTGGAAATGACACAGACCCACAGAAG


GTGTTCAAACACAACCTACTCTGCAAACCTTGGTAAAGGAACCAGTCAGCTGGCCAGATTTCCTCACTACCTGCCATGCATACATGC


TGCGCATGTTTTCTTCATTCGTATGTTAGTAAAGTTTTGGTTATTATATATTTAACATGTGGAAGAAAACAAGACATGAAAAGAGTG


GTGACAAATCAAGAATAAACACTGGTTGTAGTCAGTTTTGTTTGTTGATCCGCTCTGCCTCTGTTTTTATTTGTGGAGGGGAAGGAC


AGAATAACAATTGTTATTTTTTGTGTATAAAAATTGCCTCCCCAGCAGCCCTAGTCAGGGGCTTATAGATAAAACTCCCATCTC





HUMAN PROTEIN SEQUENCE: hP28-010.1 (Seq ID No: 62)


MILQAHLHSLCLLMLYLATGYGQEGKFSGPLKPMTFSIYEGQEPSQIIFQFKANPPAVTFELTGETDNIFVIEREGLLYYNRALDRE


TRSTHNLQVAALDANGIIVEGPVPITIEVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMI


NNVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAPKPVEMVENSTDPHPIKITQ


VRWNDPGAQYSLVDKEKLPRFPFSIDQEGDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFE


VQENERLGNSIGTLTAHDRNEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSDKDFKTLCFV


QINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFE


TAAVSNIVFKAENPEPLVFGVKYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKVGNVTAKDPEGLDISYSLRGDTRGW


LKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFPCHPLSAPGSLIFEATDDDQH


LFRGPHFTFSLGSGSLQNNWEVSKINGTHARLSTRHTDFEERAYVVLIRINDGGRPPLEGIVSLPVTFCSCVEGSCFRPAGHQTGIP


TVGMAVGILLTTLLVIGIILAVVFIRIKKDKGKDNVESAQASEVKPLRS*

















TABLE 7










MOUSE GENOMIC SEQUENCE: mD28-021 (Seq ID No: 63)



AGGAAGGAGCGGAGGCCCTGGTGCCCTGCCCTCAGTGCTGACTGCCCAGCGAGAGTGACTGGTATAAGCAAGCAGAGACCCGGTGAG


TGTGCCCCAGTGTGCGGCCGGGGCTGCAGGGGTGGCTGTGGGCCGGGCTCAATGACTTGGATTTTGCTGTGAGATTCATATAGAGTT


GTGGATGGGATGTCCTGTGTGCACGTGGCTGAGAGACGCTAGGGTGGGATGAGGGAGAGAAGGGAGCTGAGCCTTGTTTAGGGAGGT


GGGAAAGACAGACCACCACCGTGAAGGGTGGGGGGTGGGACGTGAGGGAGGGGAGCTGTCTGGCTAGCGTGGGGGACAGAGGTGGGT


GGGGAGTGATGAGGTTCATCAGCTGCCGTAGGTGTGAAATAGGCTTCCAGATGACACCAGAGTCTGCCTGCTTCTCCATTCCCATGT


TTCTGTATGGAAAACAGACTGCCTGTGAACTGAGGAGTATGGGAGGAGGAGCAGGGTGCTCAGAGCGGTGGGCTGGAGCTGTAGGGA


ACAAGGTTAGGCAGTTAGCTAGGAGTCTACATGGTGGGCTTGGATGTGAGGCCGAAGGCTGTAGATGTCTTCCTAAGGGGGCTTTGG


AAGAAGGAAAGTTTCTAAAGCAACAATGTCCTTACATTCTTCTGTCACTTCCTTCGTGGAACACTGGCAAGTGGCACCTCCTGCAAA


CTAGAGCAGCAGACAGAGCACACCCCGTGGACATGATTAGATCTGCATTTAAAGCTGGGCAGTGGTGGCCCGCACTTTAATCCCAGC


ACTTAGGAAGCAGAGGCAGGTGGCTCTCTGAGTTTGAGTTTAGCCTGGTCTCCAGAGTTCCAGGACAGCCAGGGCTACACAGAGAAA


CCCTGTCTCAAAAAAACAAGCAAGCAAACAAAAATATCATTTAAAAAAGGATTGTTTTTATTTTATGTGTATGTTTGCCTACATGTA


TGTATATATTCCATGTGTATGCCTGGCACTTGTGGCGGCAGAAGAGGGGCGTTGGGTCCATTACAGAGTGTTGGGAGCCACCATGTG


GGTATTGGGAACTGAACCTGGTTCCTCAGCAGGAGCTTTAAAACACTCTTAACTGCTAAGCCATATCTCCAGCCCCAGGTTTGCATT


TTTTGTGAGCTAAAGGCACCATTGGCTTGTGTTCAGGATGAATTGGAAGGAAATGATGGAAGGCAGGGTGCCCACTGAGAGGATGGG


ACTTAGTTGGGATAGATGAGGGAGGGGCAAATTCAAACTCCCCACAAGTTGGGTGTTTAGAATGAAGAAAGGGCCTTCAAGGGTTTG


CTGACCTGGATAACAGGGTGTCCTTGAGCTTGGTGGGCCTTTCTCTGTAAGCTTGAAGACAAGACCCATGCCTCCGGCCATCACCCT


GTTCATTGGACAGTTCGAGATATGGTTAAACAGAGGAAGCCATGACAAAGATTGATCTGAGCCAGTGAAGAGGCTCAGCAGGGAAAT


GTGCTTGCTGCCTGACCGTCCGAGTTCCCTTCCCAGAACCCAGTGGTAAATGTGGAAGCAGAGAATTGACTCCACAGAGTTGTCCTC


TGACCCCTGAGTAACCGCACACAATTATAACAAATACTTTTTTTTTTGAAAAAAAGAAATGGATCTGGTCTCGATGGAGAGGAATGT


AGATGCTGTGGGTGGTCACACTTGGTGAAATGAGCAGCAGGGTTATGCGGAAGGACAGAGGGGGCTGCCATGGGCAGGAAATGTCAG


CTGGGGAGGACGGGGGTAAGGAAACCCTTCCGTCCGTCCTCAGGTGAGGGGGCTGATCTGCTTAAAAATGCAGAAGAGGCTGGGAAA


GAAGAGCCCTTTGAGCTCTGGGATGCTGCTTGTTAATGGCTTGTCTGGAGGGTGGAGATGGGGTGTGTATGGATGGGGCCCCGCTCC


TGGAGGCTGAGTTAATTTGGGGGTAGGGAGAGACGCTTTGAGAGTCTACAGACCAGGAAGGTGCTGATGACATCAGGCAAGCTAGGA


TAGGACTGCCTGTGGTTGAAGGTGTAAGTGATTCTTAGGGGACTGGGTTCTAGAGCTGGGTCAGCCTGTAGGCCAAGGGCTTGTCAT


GTGTCAGGGTTTCTCAGTTGTGGTACTGTGACCTTTCTAGACAAGGTGATACTTCTTTGTGTGTCTGGCCTGATGTTGTAAGATGTC


ACAAGTATCCAGGGATTCTTCCCATTAGACCCTAGCTAATACCACCTACCTCTATCCCCAGTCCTAACAATCAGAGATGTCTCCAGA


CATTACCTCACGTCCTGTGGCAGGGTAGAGCCACCCTGGACTGAGAACCACTGGTTTGCATTGCCTCTTGTGATTTCACTAAATCTG


TACAACCTGGAGACCTAGGGGGAGTCACTTGGAAGGTGTGTTTATGGATCACTTGAATCTGGTTCTGAAGTGGGCAAGAGGAGGCAG


GAAAGATGGTGAACACTAATCTAAGCAATCCCTCCCCACACCCCCAAAAGGCTGAGGGGTGGTAGCTGTAGAAAGGAATCCACTTTG


ATTTTTGTTTGTTTCATAACGAGGCCCTTGTTAGGTTCTTGGCTGCCACTCACAGAGATTTTGACACCTGTGGTTTCCCCTTTGACT


TCCCCAGACATACAGAAGCTGAGGGCTACAAAAAGGGCCTCAGTGTAGTTAGAGGATCCCTAACACTGGAGTGGGAGGGGATGTTGT


TCCTGGCTGTTCACATGGAGTCTGGCAGCCCGGCTGGAGGAGGTAAGACTGTCTCAGGCTCCTTCCTGCCAGCCACCTTCTCTGCGC


CGGGGTCAAGGACAGGGTTGTGATTTATTCCCATCACAATCCAGCAGTTGGGTTGGTGAGAGTTGGACCCATGCTGGTTTTCCCTTC


CCAAGTGTGACAAGGCCTCAGCAGCGGCTGCTGCAGTACCACGCGGTGAACTGTCCAGGGCATGACAAAAGGGCTCGGTTAGCTGCC


GCCACAGGTTAGAAGATGAACAGCTCACAGCTCTTCCGCCCCATGTGCAGCTTGTCGCTTAAGCCCTGGCCGAGCACACTGTAGAAC


CCGGGATGCCCCTTCTTCTGCCCATGGCCATGTTTGGTCTCCAGTCTCCTGGGAGCCAGGGTCCTGGCCTGAAGAGGAGGTGAGGGA


GGCTAGAGGAACAGGTGGTATTTGGAGACTAATTCATATTTGTGAATAATAACCCATGCCCACAGGAAACAAATCAACCTGTGTTTG


CATATTCATGAGGGGGGCCTTTAGAATGATCCCAGCTGTTTTCCATCCGGGAATCCCTGGGTCCTGGCGTCACATGGTCTCTTGGGG


GTCCTCTTTGGCCCTGGCAGGGATAGCTAGGGTGGATCTCATGGAAGTGACACGCATTTTCCATGAGACACATACATGACTCCTGTG


GCTTGGTGTTGTGCCTGCTGATCCCTCTTTCCTCAGAGCAGTGGTTCCCAGGATCTTTGGTTTCACACACAGTTCAGTTTCCAAGAG


TGCTTAGGGCCAGACAGGGGGTTAGCAGGTTTTTTTGTTTTTGTTTTTTTTTTTTTGTTTTTTTTTGCCAAGTAAGGACATTATTAA


AAAAAGAAAAAAAAACAACTGCTATCGGCTGTCCCTATCACTTCTTCATACAAGAAAGGATATTTTAGCACCAAGGACAAAATTTGA


GAATAAAGGACATTTCTTCCTAAGAAAGGGCAGTTGGCAGCTTTACAGTGGTGTAGCAAGGAAAAGAGATATATCAAAGCCATTCTG


AATGTAGAAAAATTACACTCAATTATATCCTATAATATCGTATGGCACGTAATTGTTTTCCTGAACAAGTATGTCAGAACCAGCAGT


CCTCGGTGCAATTCACAGATGAGCTTGAGTGTCCAAGGGTTTGGGCCTTGAGTCTATCTGAATTGTCCCGGGCACAAGCTCATCTGT


CCATGCTGGTGGAGTGACTGTCTGTTCCAAGCACCGCTGTGTTGGGTGGGTGCACGAAGCCATGGCAGTCCAGCAAGGCAGACTCGT


TCTGCAGGGGACCTGGAGACCAGGGTGTAGGCAGGACCAACATCTAGACTTTTAAGCCCAGGCCTGGGACTCAGGGTGCTCACCTCT


CTTCTGATGAGGGAGGAGGCCCTGGAGCTGGGAGCAGCCTTGAACTGCCTGACACCAGCATAGGCTCTGTGCCCAGAGTCCAGGGGT


GGGAGTTGCTGAGAAGGAGAGGCCCTGACTCGGGAGACTGTGTAGTTGCCAAAGCGGTTCCCTGTTCGTCCCTGGGGTCTTCTGGTG


TTTCTAATTGTCTGTGGCCTTGCGTTCAAGGACCACTGGAAGCAGCTCTCTTTGGGGGGAGATGTCTAGATTTTTCAACTGAAAAAA


GAAAAAGGTTTAACTATATCCTGTGTATGAGTGTCTGCCTGCCTGTGTGTCTGTGTACCATGTGTGTGTCTGGTGCCCACAGAGGGC


AGAGGAGGGCGTTGCATCCCCTGGAACTGGAGTTGGACAGTTGTGAGACGCTGTGTAGGTGCTGGGAAAACTGATGCAAGTCTTGGG


GCAGCCTGTGCCTTTAACTCTGAGCCAACTCTCTGACCCCTGTTTTCACCTGGTCTGCCCATTTTCTACACCGTGGAAGTGTATACA


GTGTTCTGAACACTCCCCCTGACTTACACAGGGGCTCTTGAATCCCCAAGTAAGAGCCGCCGGCCTTTGCTATGCTGGGAATTGGGC


TCAGATAACGCTTGTGGCCAGATTTTCACTTACCTGTTCTGGGAGTGAGACACTATGGTGGCTTTACTGAGAGGAGCTTTGCTCCCC


TTTAATAGTTAATATCCACATCCCCATCCCGTGCCTGTGACATGTCTGTGGACATCCCTGTGATGCCCTTATCAGGCAGCTGTACCC


GCAGATGTCTGTACCCTCTGTGTACCCCACATGATGTGTCTGCACCTGGGAGTTAACCATGCTGTGATTGCTGTACTAAGGCAGCTA


CAGGGGGATTAAGGTTCCGTAATTGTACTGGGGAATTGTGCCCCACGATGACTGTGCTGTGCATTTTTGTACGGCGTAACATCTATT


CTGTCTCATCCCTTTATGTCTGTACCAGGGAGATGTGTCCCCATGACACTGGTACTGAAGATTATGTCCATATGGTGTCTGTGTTGG


GGGTGGGGAGCGTGCCTGGGGTACCTGAGCACACAAGTTAAACTCCAGCTTTTGTGATGTCTCACCCACGAGACCTGCCTCGACCAC


TCTGCCTGACTTGTGTGTGGGGTGTCACACTTCTGAGTTGTACCCGTGGTAATGGTACCAAAGCAAGAGTCCTATCTGAATACAGTG


TTCCCATGGTAACCTGGCCAAGGCAGTTCACCACCTGGTGTCCTCATAGCCACACTAAGATAACCATGGTGCTGTGATGAACAAGCC


CAGATAAGACTTTAACAGAATTAGAACCCCTATCCTGACATGGCAGTGTGTGGCCTCACTGTGGGCTGACCCACCTCAGCTCTGTGG


TCCCTCAGAGGAACTCCCGGCCTGGAATTAGGAGTTCTGGACACTATGTCCTGTCCCTGTAGCGTTATGGCTCTTGCTGCTTATCCC


TTGCTTACAGGTTGGGTAAGCGTCTAAGACAGGGAACATCTCCCCTTCCCAATGGTCACTAGCTCCTCGCTCACTTCACAGTCCCAC


CTGCCTTACCTTTGCCCATTCACCTCATGATCGTGGCTATCCTAAGTTCAGATAAGGGTTCAAGTCCCAGGGAGGGGCAGAGCTATG


CTTGAACTCCATCCCTCTTGTTCACCTGTCCTCTCATTTTGAAAATTCTCTTAGCACTATAGGGGCCCATGGGGTCCCAAGTTGTAG


TGAGAAATTTGTGAGGTTTTTGTTTTTCAAAAATACAGAAATATAATGGGAATGTTTTGTTTAAATCCCAGGTGTGGGGTAGGGAGT


GGCTTCAGACTGTCCACAGCAGCTGACTATGATTTGCCTCGTGCTCTAGCAGGGGCGTGATTTTTGCCAGTGGCAGATAGCTTCTGC


AATTGTATGATATTTGGAATTTGGGGGTCTTTTCAGAGAGTATTCATTCGTGGAGAGGTGGGGTGGGTTGTTGGTTGGTGGCTGTTT


GTTAAGTAGTTGTGTGCAAAGAAGGAACGAGAAGAAATTAGATATCCCAACTGTGAAGATTAAACTTGCCCCAAGAAGCTCAGCACC


CCATTCAGCAGGAAGCTCTCTAGTGATATTTTGCCCCCTTCCTCCTCTACCCTTTTTCTCTCTCCTATGTTTAGAGGATGAAAGGGT


GGTAAGAAGGGCAGAAGAAAAAAACCCCACAAAATAGCAAAGGTCCAACTACATTAAATTGTGTCCGGTATCACTCCTCCATTAGAC


CCTGTTGTATTTTCAGAGCATGGCTGAAGCCTGGCCATGCACCAGTGGCCTGTATGTGGCAGTGTGAGCAGAATTGGTGGGCCCTGC


TGCATGTCACCTAAGCCCCCAGACAGGCAATGTGGCACCGGAACCTTTAGAAGCTCACCCTAGGTACATAGTGTGGCCACTTCTGCA


TGGGTTTGCAGAGTGAGAAAGTCATGTAGACAGGAGGGTGAGCAAGGTCTGGAAGGCTTCGTTTAGCCCCAAGCACAGCCCTCCCCC


ATCTGCTCTGGACACCCGGAACAAGGGAAGAGGAAACATGGATGTTGACACTCAGGCTCTAGAATTCCAATCCACAGCCGCTTTATA


GTTTGTCTTTGGGATAGGAAGGTGCCATGGGAATTAGGTAGGTTGAGAGTGACCAGGCAGGGCAGCTGTAACTTGTAGAGAGCAGTC


CTGGCGAGCCCCAACGGGTTGTGGCTTTGGCTGTGAGCCTCTGACGATGTGGAACCAACTACTGCTAAGTCTGTGTACTGGGGCTTT


TCCTGAGTGTGCTGGGGTCTGGCCACTTGCTTTCTGAGGAAGAGCAACAGGATGCCCCAGGGACTAAGATGGCCCTGGACAGTGTAA


AACCTGCCTGGCTGCTCTCTGTTCCTGCCTCTGCCTTGGTTTTGTTTGGGTTTTGTCCCAACCTGTATGTATCTTTGACTCCATTTC


CCTGCCCTCATCCCCTTAATGGTGTGAGCCGGAAACTCACATCTGGAATGGACCCGCCTCGTGTTAGTTTCTAACTAGCTTTCTTCC


CCCTCCTGGCGCTTAGAGGATGCCCTGAAGGTCTCTGCACTCTTTCCATAGGATGGTTGACCTTCAGTGGTGAGGGAGTTTGGGTAG


CCATTGCATGGTCCAGTGTGGGACTGCTGAACTGTCTGAATGGGCAGTGAGGGTGGGTGGCAGTGGGGTGGGGAAGAGCATGTGCAG


TGGGGACTCAGGGGGACACTGGCTAATTGGCTCTGCCTTTCTCTCCATTACAGGTGGATTGTCTTAGGCTGTGGCTGGCTGTGGAGC


TAGAACCCTGGATGGCTCCCGAGCCAGCCCCAGGGAGGAGGATGGTGCCCCTTGTGCCTGCTCTCGTGATGCTTGGTTTGATGGCAG


GTGCTCATGGCGACAGTAAGTCTGACTCCTCATCATACAGATACATCATGTTGAAAATCGACTTAGCTCCTAGCAGGTCTCTAAAAT


GCAATACCGGACCAGGTCCCAGGAAGAAGAAACAGGATGACCATAGATAACCCACTAGTCCTCCTGCCCTAGAGACCTGCACTGGGA


AAGCCCTCTTCTAAGGAGTACGTGCTCCTACTTCCTCTGAACATCCTGCTGAGCACCTGGGTATCCCTTAGGCTCTGCAGAGTGCTG


CATGTCTAAGCGTGACCCTGTTATATAGAGCTGGGGAGCCGTGTCTTGGATTCATGTGATCTTTGTGTGACGTGCATAGGCATGTAC


TTTGTCCACATTGCAGATCTCTGTAGAAGGCCCCGAGCAGAAGGAAGCAGGGCACCAGACATGTCTGCAGAGCCAGGGAGGATTCAG


AAGCAGTTGCCCATATCCTTCCCTGAGGCGGCCTGCAGTCCCTGGAAAATAGGGAAGGACTTGTCACTTGGCTTGCAGGAAGGAGAG


AGGGGGCAGGGAATGAAACTGAGTCTGTGTGTTTGTGTGTTGGGGGGATGATTTGTCCCCTACTCCAATCCAACTCTGAACTTTGGT


CTCTTCCCTGCTGCTGCCCTTCCCCCTGCCTGGCACTATAAGACTGGCCATAGCCCGCCCTGTCACCATGGTTACCACTGCTTGGTT


ACTGGTAGGAGGCGGAGCACAGGACAGGCTTAGCCAATCTGCAGACTGGGGGGAGGGGCAAGGTCGGAGCTGAGGTCCCTTGGGGGG


AAGGGGCTATTCCCAGCCTGTCCTGAACCCAGAGGCAGTCCAGGGCCAACCCAGGGGTCAGACCCCAGGATAGCAGGCCATAGGGAT


CCCTCTATCCCCTCTGGGTCTCTAGACAAGAGCCTTGTCCCACCAGGGCTCTATCTAAATGGCTCATTTTTTTTTCAGGAGCCAGTC


ATAGAAGAGGGTGGCCCTGGAGCACCCCTCCCTTTGTCCTCAGAGGCTGGGCCCTGGATAAGGGAGAATGGGAGGGAGAGGGCCTTT


CTCTGGAGAGTCTAGCCAGTGGAGTGCAGGGCTAGGGGTCTAGAAGAGAAGTCAGGTGGAAAACCTTAGAAAGGGGTAGTGTGAAGG


TGATCCTTAGCCCTGGCTGGGGCTGCAGAGGCAGCAGAGGGAAGTGATCTGGGGCCCAGCACCCTAGGTGTGTGACTGGCATTGACA


TGGTGAAGGACTGTTGTCACTCTTCTCAGATTGTCTCAGGGCCCTGACAGCAGGGGAGACATGCCACTGAGTTTTGAGAAACAGTGA


GGCCTAGGAAAATAACTGCCTTCTCTATCTTCCCTCTGACCCAGCACACCCCAGCCTGCGCCCGTCCGTCCCACCATCCTGCCTGCC


CCCTGGTTTTCTCTGTGACTGGCATTACTGTCGACCTGGTTACCAAGTCAAAAAGCTGGGCCTTCTGGCAGCTCCTCTCCCCCTTCC


ACACCCCCCTCTTCCCCCCGTGTGATCTGTCCCCAGGTTCTGTGGCCTCTAGCTTCTGAGTGTCTTTGGAATGCACTCTCTGCTCTC


CCTGCCCCCTTCTGCCAAGCCTTCTTCAGCTTCTGCTTGAGTTTGAGTGTGCACCAGGGAACCTTCTGATGGTTCCCTGCCTCAGTC


CCATTCCTCTGAACCCATTCTCTAGTCTACAGTGGGAATTGGGTTGCGTCTCTTCGCTCCCCAACTGCCTGGAGAGTGAGCTTTAGT


GTCTGACTCTCTGCTACCCTACCCTCCACCGGCCCCGCTGTGCTCTCTCCTTTCGGCTGCACAGAGCTCCGTGTCCAGGCATCCTTC


ATGCCTTCTGTTTGCACTCTCGCAGTCAGGTGTGATGACGTGGGCCTGTATCCCTAGCATTTGAGAGGTGGAAGCAGGAGGATTAAG


AGTTCTAGGGGATCTTGGCTCTGTAGTAAGTTGAAGACAAGCCTGGGCTACGTGACTGTCTCCAAAAACAAACAAGGTGTGGAGGGG


GGGTGTTTTCCCTCCCTTTACATGACCAGAACTGACTCAACTGTCACTGCTTCCTGTAGCAGCAGTGTGGTCATGCCCTGGTCCTCT


GCAGCCCTCATATGCTCTTGTGGCGCTTCGCCCTCAGTCTGTCTGCCCTGGCAGGCTGAGAGTTTAGACATTTCCAGCTCCGGGTCT


AGAGGGGGTTGGTGAATAAGCGAAGGGGCAGGACAGTCCTGACCACCGTAGGAGTGGGGAGTGAGAGGAGCTGCTTTAGGGCAGAGT


TCCAGGGTCTTCCTGCTGGCACCTTGGTCATTTGGTTACAGAGACCAGGCCGGGACTTGATGGTGGAAACCAGGTGAAGAGGCTGGG


ACCCTGCCTCTGCTAAGGGTGAACCCTCAGGTGCTGTGACTTGGGCACTGTCCCAGGCCAAGAGCCATCAGCTAGGGGCTGTGGTAA


GCCAACCTTAGGAGTCAGGGTCTGCCCTCCTAGCCTACCTTTAAGTTACTCTTTTTTTTTTTTTGAATCTTCCCCCATTGTGACCAG


TCTTGGACTGAACTTGCAAGACTTCTCACTAGGGGCAAGCAGCCAGACACGGACAGGGCTGCTGCAGAAGGCAGGGCGGGTGCCCCC


AGAGAATTGACGACCAGAGCAGTGAAGCGCAGAGCGGACAAATCTGTTTCTATAGGCCTCTTAACGAGACAAATGAATGGGGGCCCT


GGCCTCAGAGGGGAGTGGAGAGAAGCAGGGGAGAGAAGCAGCTGCCAAGAGCTAGTCTGGAGGCCTAGCAGTGATGCCTAGTCAGCT


CCAGTGGAAACCTGGATACGAAGGGATGCTTGCTTGCATGCACGCACCCTTCTGGAACCTCCCTCACCTCGTGTCCCCAACCCAGGA


TTTTATGCCTTCTTGCGAGGGAAGATATAGATGGATGTGGGCATAGAGGTGGTCTTGGTCCAGCCCTCAGGCAGAGGTTTCTGCTGA


CCTCATGTGGTAGGTGGTAGGAGAGAAAGAATCTGCCCAGACCCATCACAAGACAGAACCCACCGAGCTGGGCACACGTCTGTGAGC


TAACAGATCAGTGGGGGCAGGTTGGGGCAGCGCTGGCACAGGCAGCAGCCTGATTATCTTGAGAGGCTTCCTGGAAAAGAGGGCCCC


TGAAGATGAGTGGGCATTTGCTAACATAGAGGATTGCCCAATGAAGGAATGAGACTGGCAGAGTCATACCCCTGCCCTGGCCTTCTG


AGCTTACGAGAGAGCCAGAGTCCTGAAGACAGCACAGGCCAGCGATGGGATCCCCGCCCCCAAGACCAGGTGTACGTTGGGTCCTGG


TTATGACCAGGTTATTTGCAGGCATTAAAGTTGAGCAAGGTGCTTGGTAGGTGAAGGGGTCGGTGGTATGAAGCAGAGAGGCAGGAG


ACTGAAGAGTGTATGTGTGTGTGTGTGTGTGTGTTGCTTCTCCAAAGCCCCTATTTTGGAACATGGCAGGGCCCTCCCCCTCATGTT


TATGGGTGGCCCGTCTAGACCCTGCCCTCTGGAGCTTCCGGCACAAGTGCTTTCTCTGAGCCTGTTTTCCTATTGCACAACAGGGGT


AATCACTCCGACCTGTAAAGGTTAACCGAGGTCACATGGGCAAGGCACCTGGCACCTATTGAGTTCTCCCCCTGTTGCAGTGCCTCC


TGGAGCCAGGATTGCCCTTGAGTGGACAGGGCTGGGGGAGGCTGCCAGGAGCAGTCACAGGAGCTCATTAAGTCCCCAGCTCATTGA


GTCCTCAGCTCAGAGCCACTCAGGGCCTGGGAAATCACCTCTCCAGCAGCTCCCCTGCCCTCGTGGTCCTAAAGTGCTGTGTGTGCT


TCCTCCGTGTGCAGTGCTGTTTGTGTGCCTGTGTATATGTGCTTCTCAGGGGAGGCACAAAATAGCAATCAGTCTCCCCATGGAGGA


GCCTTGGAGGTGGCCCAGTTTAGCCGTCTCTGGAGTTGCATGTCTTCATGTCTCCAGGGGCTGTGCCTCCCTCTAGCCCAAGCCAGG


CCCTCTCTCTGGTAACTTCCTCTCATGTACAGGGTCAGCGGTTGACATGTAAAGCATGGCCCAGGGTATCCTACTGTGAGTAGCTGC


CCACGGGGTTGGGTGACACAGCAGGTAACTGTGACACAAAGCTGCTCCTTGCTTGTTCAGATGACACCTGTTTTCTGGTTCAGAAGT


TTTGCTCATAGACCAACAAGATGGCTCAGCAAGTAAAGGCACTCAACCACCCATGGCCCGTACACACACACACACCACCACCACCAC


CACCACCACCACCACCAGCTGATAAGGCCCAAGGCAGGGTGGCCGCAGTAGCCTGGCTTTGCCTACCTGCCTGCCTGGCACCCCAGC


TGGCAGTGGGGTGTGGGCCAGGCTTCCACAGTCTGGAAGAGGGGGCTAATAAAGGATGCAGGGTACACACAGAGGCAGGCCTGGATT


GTGAGCAAGCTCAAGCTAAGTTCTCAGCAGAGTGCTTGCTTGACCTCTGGCAAGTGCATACAAATCAAGATCCTTGCTGGAATGGAA


AAAGGGGGAATTTAGAGAAGCTAGCAGGAGCAAATTTGGGGAGACAGGGTAGAAACAAGATTTGACTGTGATCTCTGAAAGTCTCCT


GAGGAACAACAGGAAGATCCTAGGCTAGCTAGGGCGCTGGAAGGAGGAAGAGCCAGGTGGCCCGGGCCTCTGCGAGGGTACCCTTAG


TCGGAACCAAGGCATAGAAGGCATAGAAGGAGCCTGGGACTGGAGGAGCAATGCCAGCCTGATCCTGGGCAGCACCCTGGCTCTTCT


CCAGTCTCCAAGGGAGAGGAGTAGTTGTACCTCCCTGATGGCCCCAGGCCTTGGGCACAGGCCAGCCCCCACACAGCTTCCAGGTTT


GTTCCTGCTGGCTGCTCCGGAGCTACCTGACTCCTGCCCAGCCTCGGCTCTTTGTTTGGCTCGGGAGGCCCCACCCCACCCCACCCC


AGCACACTCCTAGTCTTTCTGGTTCTTCAGGTTCCAGCCTCTGGTTTCACTGGAGACACGTTGAGGCAGGACCTGGAGGGGCACTTA


TTCCCTGGGTTTCTCTCTTGCCTAGAGGGAAGGAGTACGTGAGGCCCCAGCCTTCTACACTCCTCTCACTCCTTCCTCTGTCCTCTT


CTTCCTGTTCTGCACACCTGGGTGTCAGGAACTGGGTCAGACAGTGGGACAGGGCAGAAGACAGGACAGACATGGAATCTGCTCTGC


CCAGGGTCATGGTCTGATTGGGAAGCAACTATTAAACACCAGAAAGGTGGGAAGGCTTTAGCTTCCTGTGCACCCCGAAACTGTGGG


CAAACTGTGGGCGGCAGAGCGAGTTTGGTGGGGGTGGGGGTTAGGGAGGGATAGGGGAGAGTTTTCTGAGACGATGACGTTCAGAGG


TGACITAGGATGTTAGTGGGTAAGGGGTAGTCGAAGAGGCGCTTAGCAGAAGGTGCAGCTTACGCAAAGGCCCTGAGGCAGCATTGC


TTATTCAGGGCTCTAAAGCCAGGACTCTGGGGAGCATGGTTGGGTCAGACCTGGCAGAGCTTTGTCTGCAGTGAGAGGAGCTTACTC


TTTGTAAAGAGCAGTGGGAGGCCTTTGGAGAGATTTGATCAGGAGGAGGCTTGTTCTCTGGCTTCAGAATAGAGAATAGAGGAGGTG


GGGTGGGGGTGACAGAGGCAGGGCCATCAGCCTGTTCAGCCAGCCAAGCCGTTTGTCCCATGGACGGGATGCAGAGCTGGAAGCTAC


TGGGGTGGGGGAGGGGTTAAGAGATAACCTCAGTAGACCCTGGAGGAGGGGGCTTCCTCTCAGGCAGGTATTGGCAACAGTGATAGG


CTTTGTAAATTCTACAGACTAGGAAAGATCCACACCTCTCTCCAGAGGCGGGGGTCGGGGTGGGGGTGGGAGGGTGGTAGAAGCAGA


AAGGAGTTCAGAACTTTTGGGTCACCTGCATGACTTCCTGGCCCCTGCCTGCACTGGGCCCTCTGAGTTGCTCAGCCTCCCCCCCCT


AGGAACAGATTGTGGTGGGTCCCGAGCTTTCTTCCTGGGGAGGACACAGGTTATTTAAAGTGAGTTTAGGATTTAGAATGTAGAGTG


AACCCCAGCTCCACCCCAGAACACTGACTCATTGGTCCTTGTTCCTTCCACTGCTTGGATGTCTTTCCCTATCTCTAAAATGAGGGT


GATTATGGATCCACTGACCCACAGGGCTGCTGATGTTAACAAGTGACTGCCTGCCCTGGGTGAAGGCCTGCCACTGACACATGTCCT


TAAAAAAAACAAAAAAGACCAAAACAAAACCAAAAAAAAACCAGAATTGGTGCTGGAGAGCTGGCTCAGTGGTCAAGAGTGCTTGCA


GCAAGTGATCTTGTAGAGACCTGGGTTTGCTTCCCAGCACCCACATCAGGCAGTTCACAGCCACCTCCAGCTCTAGAAGATCTAATG


CCCCCTTCTGGCCACTGTGGGCATTGCACACATGTGGTGCACATACAGACAAGCAGGCACGTATACATAATACAGATAAAACTCCAA


GAGTTTCTAAACCTTCCTCCAGTTGGCATCTCTTTCCTAGTCACAGCGTGCTGTGACAGTCACCTGTGCCTCTCCCTCACCTTGGCT


ACTCCTCTGCTTTTGTCTGACTTTTGCCACCACTGGCTGTTCTCTTCAACAAGGTCCCCTGCCTCCTGTGAACTTTTTGTGTCAGGT


GTTTTGGACTTTGATGGGCCTACATTTGGGTCCCAAATGTGTCAGTACTCACTGGCTGTGTGACTCTGGGCATGTGACTTGGTCCTT


CAGCCTAGAAAGTGGAGGCACCGGTTGTGCATGAAGTGACATAAAGTACCTGGCGCACAGTGGGCACTTTTCTGCCAGGGCCCAAAC


TGAGCCTGGGTTATGGGCAACAAGCAGGTCCTCTGAAGGGCCAGCTCCCAAGGCACTGGCTTTCCTGCACCGTGCACTGGCTGCACT


AATAGGAAACGGATCCACAGTCAGGATTAACGAGGCATTGCTACGTCTCAATGAGCCAGCTTGCTTGGGGCTGTGACCCTGGGTGGT


GGGACATGGAGGGTATGGCCAGGCCTTGGCTGAGCCCCTGTCCTCCTCCTTTGGAGTAGGAACTCTGGAGCTGCCCATGCTGTGGAA


AGGCAGTTGCCAAGCCGGTGGGGGCAGGGAGTTACAGGAAAGCATCCCTCTGGGAAGTCATCCAGAGCCTCTCAGGAGCTGGAATGT


CCAGGCCTTTGGGGCTGTTGGAATGCAGGGGTAGGGAAGAGGAGGAGTCCCGGGGTCTGCCTAAGGCTTAGCGTAGATGGAAAGGCT


CTAGGAGAGTCTGGGGCACTTCCCAGAAAGCAGTTCTCCAGTATTGTTTTTATTTTTTTGTTATTCCCGGAGCTTGGAATAACCAGG


AGCCGGAGACAGACGGAGGTCGAGCCCAACTCCAGACTCTGCTCTTGACCAGCTGTGTCCCAATGAACAAATCTCTTGACCTCCGCA


CACCTTGATTTCTTCTCTGTAAACAGTAATTATAGCACCCACCTCCTTGGCTTCAAAGAGTTACAAGGGTTCCGCTCTTTGAACAGG


GCTCGGCACTTATTAAGCACTATATAAAAGTTAGGTATTATTGTTGTTCTCTCTAAGTCTTTCTTGCCCCCTCGTCCCCAAGGCCTG


CTACCTGTAGCATGGTAGCATTGACCATGCCTGGTGTGATCATGCCACTTGATTTGAGTGTCTCTGTCTCTTCCAGGCAAACCCGTC


TTTGTTAAGGTCCCCGAGGACCAGACTGGGCTGTCGGGAGGGGTGGCCTCCTTCGTGTGCCAAGCCACAGGGGAACCCAAGCCTCGA


ATCACGTGGATGAAGAAGGGGAAGAAAGTCAGCTCCCAGCGCTTTGAGGTTCGTCCTGGACTGGCCGGGAGGGCTGGGCAGGCTTTA


GAGTTGGCCTGCTCTCTGTGTGGTCCTTCTCTTGTTCCTCAAGGGTCTTTTGGGGATGTGAGGAAAACTATAGTAGATCCACACACC


CCTAACAGGCTGTGACCACGTCTGTCCTGTGACAGGTAATTGAGTTTGACGATGGAGCAGGGTCAGTGCTGCGGATCCAGCCATTAC


GAAGTGCAGCGAGACGAGCCATCTATGAGTGCACAGCCACGAACAGTCTCGGGGAGATCAACACAAGTGCCAAGCTGTCAGTGCTTG


AAGGTATGTACCAAGAGGGACAGGCCACCGTGGCCAGGTAGACTGAGATGTGGGTGGGGCCCACCAGGACTGGCTGCCCTGGGGTGG


GTGAGAGTCAGTGCTCAGCAGGCCAAGGTCACTGGTCTGTGTTGAAGCCAGCAGCGAGCTTGCCAGCTGTGTGATCTCCTTCCTGCT


GGGTCATCGCTCCCTTGGGTCTGGGTCAGGCTGGAGGTATGGTGCTGCAGCTCTGTGGCCCTGGGGTTACGTGACGGTGGCAGTGAA


GCCTGGCAGTTGCTGGCAGTGTTCTCTTGGTACCCTGATGAAGGAGCTGGAGCTGGCCTCTCCATGTGAATTTTAGTGTCTCTTCTC


ATCTGGTGGCTCGTTCATTCATTTAGTCATTCACAAACTTTGCTTGAACTGCCGTTAAGCCCAGAATGTCACTTGATACGTGCTACC


CTCAGTCAGTGTCCAGTAAATTCTGTAAGGAACGTGGACACTTTGCTTCTAGGCCTTTGCCAAGACCCGGGGTGTAAAGGGGAGCAG


AGCTTCCAGAACTCTGAGTGGTCAATTTGAGGCTTTTCAAGTGGCGGCTGGAGAGCGGAGGGGAGGGAGAGGGGGGAGGGTAATTCA


GTGAGGCTGCAGGATCAGGCTGAGGAACGGGCCCTTTCTTGAGGACGTAGAAAGCCACAAATAGGGTGGGAAGTGACAGGATTAAAC


CTTGACCACAATGGATACATGAATCTGAATGTGCATTTTCAAAATACCGTATTGATTGTTGCTTTCATTTTTGAATGCAATACCAAT


ATCTGTTCACTGTTAAAGAATTGAGAAGCATAGGATAGTGTGTAGGGAGAAATAATAATCTCTTATTATCCTACCCCTAGTGCTATT


AGTTATTTCTTGGTGGTCCATTTTCTATGTGTATGTTTTATATACATCTATGTATATTTGTATTAATTTATATAAACAGAATAGTGA


TCACACACTGTTCCATGACCTTGGGGGTTTTTTTTTTGTTTGTTTCTTTTCCAGCTAGAAGGCAAACCTAGGGCTTTTCAGACAAAC


TCCCTCACTGATTCCTGGAGCTCACCTATTTGGCTAGCCTAGTGCCAGCGAGCTCTAAGAATCCACCTATCTCTGCCTGCCTCCCCA


GCACTAGAGTCCAGGCACTCACTTCTGTACCCAGCTTCCTCCATGGGCTCTAGGAAACACAACTCAGGTCTTCACGCTTGCTCAGCA


GGTCCGTTACTGAGCCACCTCCCCAGCTCCTCCTGCTTAGGAAAAAACATAGTGTGAAGATTTTCCTTGCCATTAAATATTCTTCCA


CACCATTATTTTTAATGGCTGTGGTAAGCTGTCACATGGAAGCACCCTAATTTATTTAGCTGTTCCCTTTTTGTGGGGTGCATATGT


TCTCAGCTTCCAGCCTTTGTAAGTACGGTGTCACACAAGTCTGTGACGATGCCGTTGCTTTGCTGGTCATTTCCTGACTCTAGGTTC


GTGGAGTAGAATTGCTAAGTCAAAGGGCACATGCATTTTAAAGCCTTCAATATTGCTAGAAGATTGTATCTGTTTATATTCTTATCA


GGGAGGGCATACGAGGGCCTCTTCTCTGCACATCTTCACCAGCAGTAGAAATTACCATTTTTTTTTTTTTTTCTTTGCCAAGTTAAT


AGGCAAAAAATGGCATCTCAATTTAATTTGCATTTCTTTGATTACAAGAGCAGTGGAACATCTTTTCACATTGGCCATTTTTATGCT


TTGGCTTTATGTGTTCACACATGCATCCATTCAGTAATTCTTGCATCTGTGTGTCTCGTGTGAATCAGTGGGTTCTAATAGAGCTGT


GTGCGGCCCTCCCCTGTAGACAGGAACGCTGGGCCTCATTTGTTCCATCCGGGATCCAGGACATCGTACCCACAGTCCAAGCTAGTG


TGGAGCTTTCCCTGTAGCCCAGGATCTCAGAGTCCATTCTGAAGTGTAGACAACCTGAGCCGCTGCTGCTTGGTGTCACTGGGTTGT


GCTAGCCCTGCTGTCCGTTCCATTTGGGGACAGGGGGCCAGACAACCAGGTCTGAGCTGAAACCACTGGCTTGGAGGTTCCTTCTGG


TCATTTCTGACCTCCAATTTGTGACCCAGGAGAAAGGATTTCACCTGTTGGTGTGAGAGTCATCTACCCTGCCTTGTATTGGAGTGG


AGTCTAAAAGACTAGAACTATAATCCCTATCATGGCGGGCAACCTCTGAGGCTCTCCGGCTAGGGAGTAGTCTCCTTGTGAGACTGG


AGAGCTGATTCCTCTAAGACATCCCACTGCCCTGTCAACTTTACCCTTTAAAGGGTCTCTCAAGGCCCGGGGAAGAGAACTCACACT


TGGCATAGGGTTGCCATTAGAAACGGCCTTCCTGGTCAAGAGTTTCTTTCCATGGATTAGAGGGTGTTCTTTCTTATGTGGTGTTGG


GATGACCCCGGTACTAGACATGGACTTTTATCCCCAGACCTGGGCTTCAGGCTATATGTTGATGCATTCTGGGAACTGGAAGATGTC


TGATGATGTGTGAGACAGACAGGTCCCTACTACACCAGAGTGGTTGGAATTGTGGGCTTCGTGGGCCCCTCCTGCTCCTGAGATATT


GCACCAGCGAGGCAAAAGTGCTGACCTGTCCTGTTGTCTTTGTAACCTTGACCAGCTTAAGGCTTGGCAGAAAGGAATGTCACAGGG


GATAAGACCACGGAGAGGCAGCCTAAAGCAACCCTGCCTCATTTCCTCCCTGTTCTTCTGGGGTGGGGGGCAGGAAAGCTGGGGTGC


TTGCCTGCAATAGATGAAAAGATGGCTTTTTTTTTTTTTTTTTTTTTTTTGGAGCTCTGCGGTTGACACGAGGGGAGAGCCAGGGCC


ATTTTCTATGGAGAGACTACCATAGAATCCTAGTAGTGAGAGATAAACTTGGCTTAGGGGCTGGAAGATAGTGCCTGGTTGCTTTGC


TCTCACGTCTCACACACATGTGCCCGCCTGTGCATCAGGAGACAGGTGCTTTGGGGAGTTCCTGGGTAATGCCTGGGGAATCTGGCC


CAGGTGCAGGAGCAGTGTGTCTTCAAAAGGGAACCCCAGTATTATACTTCCTTTGGGGCCTTCTGCCCTTCCTCCTACCACCCCAGG


CCCAGCTCAGTCCACTCTCACTGCAGCCTCTGGGGACACCACCATTGCCAGGTCCCCCACGAGTCTCTGTACTCTGCCGCTGCTGGT


GCAGCTTGTGAGACCTAGCCCACTATGCTGGGATGGCCAGCCGGTGTGCCAACATCCCTGTCAGGGTGCAAGGTGGGGTGTCCAGCA


CAAGCTGGCTGGGGCTGGGCCTGTCCTGTCCTGGGCTGTGATGAGTACCAGGGCCCTGCCGCCCAGCGTTCCTGTCTGAGTGGTAAT


TGAAGCCATTAGCGCGCCAGCCTCTCCCTCGCCGGGTAATGGCAGGAAAAGCTCTTCTCGCTCCGCACTCTTGAGGCGGCGGCTGAA


TCATTCCCCCTCCAACCCGCCCGCTGCCGCCACTGAGACAGGGAATCTGACATTTTCCCTCACAAGGGAGGGGAGGGGTGGGGGAAG


GGAGTGAGGCCTTGATTCTGGGCTTTCCCTTCCGAGGTGGAGGGGGATAGTGAGGGTGTTGAGCTCAGTTTGGAGGTCATTAGAGTC


CCCAGGGTTTGCAGAGTCCAGGCCAGGCAGAACCATGGTTGGGGAGAACTCCAGGGAGGAGGCTAGACAGCCAAAGCTGTGGTGGAG


CCCTAGTGACTGGGTAAGTTCTGGAAGGGACACCGAATGCCCAAAGGAAGATGGGGACAAGAGGCAGTGGAGTAGGACTTGTCCTGG


GGGCCGGGCTCAAGGGCTGGATGTTTGTCATTTCGTGCACATAGAAGATGATGTGCTTACAGTGGTGTGAGCATGTGTGAAGGGATG


TGTATACCAGCAGTGTGCCTCAGGCAGCTGGGGAGGGGCATGATGTGTAAGCAGGTGGTATGTACTTTAAGGGCTCTGTGCAGTAGT


GAGATGTGTGCATGTGCACGCATCTGTGCATGGCAGGTAGTATCTAGGGTGAGTGTGTGTGTGAGTGAGTGTGTGATACGGGTGTAC


AGCAGGTGGTATTATACCTTAGCTTTGTGAACAGCGAGAGAGTCAGCAGTCTGAGTTGGATGTGTAGGGTCAGTCTGGTGCTGGTGG


GACGTCAGGTCCCGTATTCAGATTTGTTGTTTCTGGGGTCCCACAGAACAGCGGACAACAACGAATGCTGGTCAGTGTGGTTGGGGC


TAGAGTGTTGTTGTAATCTGCTGCCATCATACTCAGCAGCTCCTCTGTGACCAAGCCAGGAGGAGGGCACACTAGGAGTCCTGACCA


AACCTGGCCTTAGGATTTAGGACTTCTCCTGTCTTCTCCACCCCCCACCTACACTTGTCCTTCTACCTGCTTCCATCTTGGGCTCTG


TGTCTGCTAAGTGGGCCAGACTGTACCACCTATGCCACTTGGCTGGATCCAGCTAGAGTGTCTCACATTGCCTAACCTGGAGAGCAG


GCAAGAGAGGGCGTTTCAGTTAACACTGGATCGTGGGTTCTGCATTTGCTCTCACCCTCGTGGGTTCTGAGGCTTTAGGGTGACAGA


TAACTTCTTGCCACACACGCTCGCTCAAGTGTGCGCGCACACTTACACACACAAACACACACCTCCCCCAACACACACATATGATCT


TTGGAAGCAGCTCCAGAGGAAAAGACTGATGGTGACCCTGTCCTGAGCTGTCCTGCCTGAGCTGGGCAGGATGAGTGCTTTCCTAGG


GGTCATTTTTCCCTGCCCCACCTTTTTTCCTACCATAAGCCTTTCTATTCCTTTCACTCTCAGTGGAAAGATGAGGGTGAAAGAGCT


ACTACAGGAAGTCCCAAACCTAGAATTCTAGGCAACCCCTGTTCTCCCCTGGCAGCAGTGACACTGATGTACCTCTTGTCCAGTGGC


CTTTAGGACGTAACCTCCATTTCCTGTGACCACAACAGATCTCAGGACCATGAAGATATGAAATACTATAGCCAGATTTTGGAGGTT


CAGACAGAGATAGTCTTGGGTAGGAAGGCACATCTGGAATGGGGCAGTAGAGGGTAGGAAGGCACATCTGGAATGGGCCAGTAGAGG


CAGCTGGAAGGTCAGACACGGGGTTTCTTGGTTCCTGGAGAGGATTCTCATGGTTTCCAGTTCTGAGAGTCTTCGAAGAGCTCAGTG


AACTCCTTTTGAACGGAGTCCCCTTCTGTGAGCTGTGGCCTGTGCCCACCTAGTTCCCCACGCCCGTGCTCACAGGTGTCTCGTCTG


TGCTCTGTGCTTTTTGACACCCCCCCCCCGTCTCCCTGCCCAGCTTATGATCATGGGCTGAACCAGCAGCGCTAGAAATAGCTCTCA


AAGTTGGAGGTCTTAGATACCCCTGGATGTATATTCTCCATCTGTGGTGAGGTATCCTCCTCACCCTGATTGCCAGGGGAGAAGAGG


GCTTACTAACGGCAGATTCATGCTTCAGAGAAGTCCTTGTTGATGCAAAGTAGGGCGGAAGTGTATCTATGAGAGGTAGGTGTAGTC


AATCCAACTAGCAAAAGCCAGCATCACCCGAACCTTGTGAAAAGAAGAGGAAGGGAGATAGATCAAGAGCATGACAGGTAGCATCCA


GCCCAGCTGCCTGGGACACCCCAGGGGTGGTTGGCTCTGCATTCCTGGTTCAAGGCTGGTAGACAGCGGAACCAATTTTCTATCTAA


GATTGAAATACAGGAAGAGGCCCAGGACTGAAGAGGTGAGTTGATAAGTCTGATTTGAAGTCTGTCAAGTCAGGTGTGTGCAGGCAT


CCAAGGAAAGATGTGAGAAGGCCECACATGGGTTTGCCTGGCACTCTTGAGGGGCTGGAGATGGAATCGTGAGAGCCAAGAAGCCAA


GCCAAAAGGATCCCCAGGAACTGGCGTTCACTGTTGGGAGGAGGTTCCTGGGAGCTAAGGGGGAGCCAGAGCAGGGGAGGCAGTGGA


AGAGTATGAAGGAGGAGAAGCCAAGCAAGATGAGTATTGGGCAGTGTCCTTTGGATTTAGCTCTGCAGTTGGCACTGACCTTGGCGA


ACAGGCTTCCAGAAGCCTCGGCGGTGGCAGCAGGGCTGCAGGGGGCTGAAGAGCGAGTGGGAGGCTGTCAGTGGTCTGAAGTGACTG


CGAGCAAGGGCTGAACCTAGAGAGGTAAATGGCTAAAAAGAAAATTCCTGAGCAGGCTTGGGGTACAGGGGCATCAGGAGGGAGAGC


CCAGCATGAGCAGAATCTGAGTGTGGGGACCAGGCAGTGGCTCTCGGGTCCACTGAGTCCAGTCCGCACGGTGGGGAGGCCTCACCT


GCCAGGTTGAGTAGGACTCCGTGGAGTGCCAGGGAAACCCAAGGGAGGGGGGATTACTGAGTGGGGGAGGCCGTGGCTGCCGACAGG


CCCCAAACAGCTCAGACTCAAAAACAAAACAGGCTTTTAAGATGCCAAGTTTGATGAAATCTGAGTGCTGGAAGAGGTGGGAGTTTT


CTCTTGGAAAAACAGCTGAAAGTCGAGACTGAAAGCTGCGAAGGGAGATGGGCGCTGAGGCCCCTTGGGCCCCCCTTACCGCCTGGG


AGCCTGGGGGTGGGGTGCAGGCTAGGCACTGAGCGGGAGAGCTTACAGGTTTGGGGAGGGCTCTGTCTTGACCCTGTCTCTGCTGAG


GATGGAGCTGTTCTGGGCGGCTGAACTGAGGGTGGCCCTGGGCTTCCTTTGGAGTGCCAAAGGGCAGGGTGGGGCCTGGCCACCCAC


AGAGGTTCCTTTGTGGGTTTGGTCTTACTGTGTCTCCAGGTGCGTGTGTCTCTTCATGTGTGTGTCTGACTTTGCATGTCCTCGCAC


CCGTGTTCCCACACCTCTGCATGCCGCCTCTGGATCTGCCTGCAGGAGTCTGTTGCCACAGGTGCTTGTCACTGCAGATGCCCCGCC


ACAGGCACATGGAGGTTTCTATTTTTGCACCTGTCTCTTTCTCCTCGTAGTTCTCTAGGTCCCTGGCTGTGCGTGTTTCTAAGGTGT


CTGTGTGTTCAGGGACAGGGTGATACACTCATGCATAGAGGAGGGGTCAGCCTCACAGACTGTGCCACCCCGGGGAGCCAGTCTATG


TGCATGCGCATATGGGCCTGTATTCAGAGATGCCATGAAGCTGGGTAAACACGGGTGAAGAGGTCTCTCTGACAGACGGTGCCAGTG


CTCTCCCTTACAGCCACCACCCTCCCCTCTAAGGCATCTCCATCTGTTAGCTTTCCTGGTGCAGCCCCCTGCCTCTGGCCCAGACTC


CGCCCCAGGCATCCCTGGCTTCATGGACAAAGAGACCTGTGTGTGTTCTCTAGAGGCCTTCAGCAGCCTCCCTCCCCCAGTCCTTGC


AGCCTGTCGGTCTAAACTTCCCACCCACCCCTGCCCTCTCCTTGTCTATCAAAACTCCAATACATACCCCAGACTCACCTTGCTGTT


TAGTATTCCTCCATCCTGGCTATAGTCTTTACCCGGCAGTGTGCAGGAAAGCTTTTTGCTTTGCATCATTCTTGATCCTCCTTCCTC


CAGGAAGTCACCAAGATAGCAGATGAGAGGTGGAGTTATAGTAATTAACTCTACTGCTGAGGGACATCAACCATGCTCCCTGTCTCT


GTCGTTTGTATCCTCCCCACCCCACCCCTTAGACACGCCCTCCCACATGCCCTGTCATCTCTGAGCTGTAAGACAACAGGACCTCTC


CAGGGAAGGGTCTCTCAACCGCAGTATCTGAAGGGCCAGTTGGGTACAGGAGCCATTCATGAACCACTTGGATGCTTACTCTAGGTG


CACAGATCTGTGCCGGAGGGGCAGACTTTCGATTATGTGTGGTACTTATGTATAGAGGCTATCCAGGTCTAGGCTACTGTGTTGGTC


CCTCTCCAGAGTCCCCCAAAGCTAAGGGACTTCTCTTTCTGCTCTGGGAACAGTGCAGTGGAGGACCTGGCCGACACTGCGGACTGG


ATATGCAGAGGCAACTTAAGAGTCTTCTGCACTGTTCTGGACCCTAGCAGGCGGGAGCTGGGTGCGCTGCGTTGGTGGAGCTGGAAT


GCCTAAGGGGGAGCACCCCCCCAACTGAGGCGCAGGGTCCAGGGAGGGGGCACGGCTGCTCCGCCTAGGTGGGGGCGGGAAGGGCGG


CGCCCAGTAGGACTTGGACGCGGAGGCGCGCACCCGCTCGGACACAAGCGCGCGCAGCCCTTCCACCGTGGCACCCGCCTCTTTGCC


GTCGCCATGGTTACCGGGTGGCCTGGAGGGGGGAGGGGCCCTCCCGCACCAGCAGCCCGTGTTTGGAGGGGCTATAGCGTAACCCGT


GCACCCACACACACACAGGCGCGTGCCAGGGATGTCCACATGTGGGGAGCATTGGGCTTCCTTTACAGCACCTGAAAAAACGTAGAG


GCGTGTGTGCATGGGGGGTCTGCAGTAGAGTCCGTAGCCGGAAGCCGCTTAAGGCCGGGGAGAGGGGGAAGGGCGTGGCTCTTCCCA


GGGACGCCCCTCCCTTCCCCTGCCCTGCCCACCTTTTCGTGAATGCTAGTCTAAAGCAGCAGGGTCCTACCACCTGCTTTCCTCCAA


GCCACACCTCCAATTTAACTGAGTGACCTTGGGCAGGTTTCCAGATTTCTGCCAAGTCCCCATTTGCTCATATGCCTCATAGGGTTT


TGGTAAAGATTGTCATTTTGTAAACCTGAAACAGAGGGACTGCTTCATGCTTGGAACCTTTTATCCCTGTGTCCAGAGGCCTCAGTT


TTCTCAGTTGTTGATGGGTTGGAAGTGACAGTGTGGCATGCATCCTCTTGAGAAATTTGCCTTGGTCATTAACCTGAGTGGTTTGGA


CTTCTATAGACACAGCTCTGGTGGTGGTGGTGGGGGGGGGAGGCTTAAGGTGGCAAGGGGGCCAGTCACTCCGCAGGCATCTGGGGA


ATGTCTGTTGTCCTTGACTGATAAGAGTGTGCTGAAGGCTCCCAGGTGGGAGAGGAGGAGGCTGCTGCAGCAGCAGGTCAGCCCTCA


GGGGCTGACTTCCCCTCCTGGAGTGGTCTAAGAAGCAACCTTGCCTGTGCTCACTGCTTGGGAACCTAGCTGGCCCCAGGGACTTGC


TTTTGGGTCCTGCTGTTCAGTAGTCGCTCTTCACACTCCCTGGTTTTAGGCTTTGGCAGTGGCGCCTAAGGAATGATCTGAGCCAAG


GACGGAGCCATTTGAGGGTGTGATAATTGAGGGAGGAAAATTAATTGTCCTTAATTTGGCGTAGGTCCCAAAGACCTTCCCCGTGTC


AAGAATTCAGAGTAGATCCCTGGGACCTACTCTGCTTTCATTCTAGATCAGTGTTTTGCACGTAGGCCATAGAGGCTGGAGAGCTCC


TTGGCTCTGACTCTGCCAGGACCTAGCCGCCCCTCATCCTGCACCCCAGTTGTTCAGACAGACAGGAGTAAGCCTGGAAGAACACGC


TCGATGCGGTGGTCAGTGATGATAGCTGTAGCTCTAGCAGCCTTGGGATCCCTGATGCTAGATGGGGATGGGGAGGTTGCCCTAGGC


CTCAGGGCTTACTCTTAGCTTCCAAGTGGTGCCAGGCCAAGGAAGCTGTGCATCTTCAGTCCTCACTCCCCTCCTCTTTCTCTTCCT


GCTGCTGTTTAATATGATCCTTTCAAGAATCAGCTGAGCCGGGCAGTGGTGGTGCACGCCTTTAATCCTAGCACTTGGGAGGCAGAG


GCAGGCAGAGTTTGAGGCCAGCCTGGTCTACAGAGTGAATTCCAGGACAGCCAGGGCTACACAGAGAAACCCTGTCTTGAACCCCCC


CCCCCCCCAAAATCAGCTAAGAGTCAGAGCTCTGTGGCATCATACTTACAGCCAAAGAGACCCAGGGTTTACATCAGAATTTATAGG


GCTCCAAACAGGGAAGTGTATAGCCAATTCCTGGCCAAACCTGGGGATTCAGGGCCATGATGAGAGATCTCCTATAACCCCAGCCAG


ACACCCTTCTAGGATATCCCTAGAAGTTGCAACTTTGATGGAGGTTCCTCTGCCTGCGGTGGCTCCTCCAGCTTCATCTTGTCTGTG


CCCCGGGTGCTGTCACCCTGCCCTTTACTTTTCTCCCTCTGAGGCTGAGTCTTCCTGGCATGGGAGCCTGGCTGCAGCAAATGTTCC


TGCACACTGACCTGTGCTGGGCATGTGAGAGGGAAGAGTGGAGTGGTGCCTCTGCCACCACCATACTGCCCAGCTTTCTTGCCGAAA


GGTAAACAAAGGGCAGACATTCTCTAGTCCCTCATTAGGTACACCCAGAGCCAAGCTTGGGAAGAGGAGAGGTACTGTTGAATTCTG


GAAAACACTTGATGCTTTTGTTCCAATGGGAAACCATAATGGGAAAGGGGGCCCCAGGCTATAGTTCTGGTATCTGTCTGCCCCAGT


GGCTCAGGACTGGTTAATTATAACTTCTAACAGTTACTGGGTGCCTGTTCCGTGTCAGATACTCCCTTAGCACCCTGGATTCTTTTT


TTGGTGGAGTCTTCAAGGTATCTTTACGAGGTGGACACCTAAACCCAGTAGATAAGTCAAGCATCAGTGAGTAACGAACACGCATAG


GCCGTAGAAGTGGTAGTCAGTGGTAGAGACGTCCGTCCCACATGGTCTACACTGTCCCAGGGCTTGTCTTCCCAGCTCCTGGTGAGA


GGTGGGCATCGGGCAGCTTTGTCTCAGCTTGTGGGGACTGCTTCAGGAACCTACGGCAGGAGGAAATGGGTCAAGTGAAAGTGATTT


CCTTTGTGAGTCGCTAACTCCAGGAAATAGTGGGAGGGTTGGTTTTGTTTTTGTTGTTGTTTTTACTGTTTGGTTTTTTTTTTTTTT


TTTTTTTGTCTTCTTAGCCTACACATACTCAGACATGGCCCTGACACCTTATCCTGGTTCTTGGGGCCAGGAATGAGTAAGAAAGAC


CAAGGGTCAAGACTATAGTAGAGGATGGTCAGAGGCAAGACTAGAGTTTGGTCATCGGTAGGGCAGGGCCAGGGTCAAAGACCTGAG


GCTCAGCCACATGGAACAGCTGAAGAGATGCAGGCCAAGGAGAGATAGCATGTGTGCTGACAAGGAGCTGCGGGCTGGACCAGCACA


CCTGGTGGGGTTGTGGCTATTGATGCTTGGGGGACTTTACTTCCCTTGCCGCCCCCACCCCGAATCTATATAGCACTTTGCCACAGC


CAGCAGAGCATCGATCCCTGCTCTTCCCAGGACCTAGAGAGATAAGTGCTGACGTCTTTAGTCTGTGCTTCCAGACTTGGCAACTCC


CCAGCAGGGATGTGGTGCTATGGGCCCTCCTGCAGCCCCTGCCTTGCCCAAAGGGACCTAGGACTCTTGACTCCTCATTTGGGGTAG


GGCTTGTGTTTAGAAGTCAGGGGTGGGAAAGAGAAGTGTATCATGGGTTCCCTGCTAACCTGGAAGTCAGGAGAAAGCTACACAGAG


AGGCCCTCAGTGGTGCAGAGGCAGTCCTAATGCACGCGTCACTCTTTGTTTGCAGAGGACCAGCTGCCGTCTGGGTTCCCGACTATC


GACATGGGACCTCAGCTGAAGGTGGTGGAGAAGGGTCGCACTGCCACCATGCTGTGTGCAGCCGGTGGGAACCCAGACCCTGAGATC


TCTTGGTTCAAAGACTTCCTTCCTGTGGACCCTGCTGCAAGCAACGGTCGTATCAAACAGCTGCGATCAGGTGAGCTGAGTTAAGGC


AGAGTCCTGAGTACCTTGGGGAAGGCACCTTCCAGCCTGGTCCAGCCAGGTGCTGGAGGATGAGCTTTCTAAGAAAGACTCATTAGA


ATGTCCCTATTGTCATAGGGGACAGGATGTGGTGGCTAGCGCTGTCCTGATCCTTCTGGCATTGTCAGGCACCACACTTTAGGCCAG


TTTTGCTCCTCCAGGCATGCGTGACACGCCAGTGTGGCAGGCCTGAGGAAGGTGCCCTGGCTTTTCATCTACTTTCCTAGAGCCCAG


TCCACGTCTCTGCTTCTCTAGGCAGCATGGCTTCCTGGGGAAGGGGCCAGTGATACTTAATTCATCTGCCTAAGAGCCTGAAACTAG


GGGCATCTGCCTCTGTGCTGTGGCCACCAGAGCCACCTGTTTCCCTCCCGTGGATGTCTCAGTCGAGCCACCTTGGAGCCCTGGGAA


CAAGGATGCCATTGTGACCAGGAGGGAAGTGTCGCCCCGTTGATCGATCTGCCTGTGAGGCTCCCGCCAAGAAAATGGATTTTGATT


TTGTAGGGATGGAGTGGGTGGGAAACGAGGCTCAGAATCCGCTGGGCTGTGTTCTACACCCGCTAGCAGCTCAGGACAGACCCACAG


ACTTGGCTCCAAAAGTCCTGCTGTCTGGGAGAAGGTAGGCCTTTCTCACGTGGCTTGACTTCCTGCTGCCTATCAGCTGTGATGTCA


ACACCATGAAGGATGGTGTGTCTGCTTCTCTTAGGGCTCTTCTGGCTTCAGAGGTACACACCAGTCCCAGCCCCTCCTTAGCCCCTC


CTTTCAGGCCCACACCATTTTGGTACCCAAGAAGAGGAGGGAGTGATGAGACACCCAGCAGGGCAGGATTCCGGCCCCAGCCACGGC


CGCCTGAGACAGCCCACGAAGTGTTAGCTCATTTAATTTAATTAAAACTCAACAAGATGGAGGCAGCTGTAGTGCAGTTAATTAAAA


CAGCCATAATCAAGGCAGGAAATGGTCCGGCAGTGTTTGTGGCTGCTGCCCAGCACAGCACAGAGGCCGGCATGGCTCCGCTCCCCT


GTATTTGTTCATCGGTGCCCCCAGGCAGGTTCCCCATGCTGCCAGACGGTCCTCCCCGCAGGCCTGACTCCTCCCCGGAATGGCATT


GACTGTCTGTGGCAGGCAGCAGTTCTGGGAAGGCCCGCTGTCTGCAGCATTTGTTCATCAAGTATTTATGTAGCGCTTGCTGTGTGC


CAGACCCCGTGCCACCCCTCCCCTGCCCATGACTCCCCGGGATGCTGCGCAGGCCTCTTCCTTCTTGTCCGCACAGTGACCGACAGC


ACTTCCTCCTCCTTGAGCAAACCTCCTGCCCTCCCTCGGGCTTTGCCACCCCTGATTTCCTCGAGCTGTGCTGTTGTCTCCTTGCCT


GAAGCCCAGGTGGGTTCTTCTAGCCCAGAGACCTGCCAGCCTCACCTTTGCTCTAACAGTCTGTCCTCCAGCAGGCAAACCCATTGC


TTCTGGTGCTTCAGTCACCGCCTCCTTATCTGTCCTGATACTGGTCAACCCAGCCCAGATATCCTGTGAGCTCCAGGTCCCACATTT


GATGGGTGCTGTCTGGATTTCACCCTATCATGGATGAGCAATGACTTCTTTACAAACAGCCCTTCCCTGCTCCTGTTGACCATTTGT


CCATGAGTAGCAACCTCACCCCCACCCCCAGAGCCCAGCCCCCCATTTAGTAAGGATCCACATCCTCTTCATGCCTCACCAAATGGA


TCTCAGATTGGTGCCTTCTTTCTTTCTGTTGCCTCTGTCCTAGCCTGGGACACCACTCCTGTTCTCCCTGCCTCTAAACTTGCTCTG


AAAACTCTGTCCTCCGGCAGCTGTTGGTGTTGTCCATTCATCTTCCTCCTAGACTCCGAGAGCCAGCGCTGGACCCTGGGCTCCTAA


CCCTTGCCCCTGCCTGCTTGGTCAGATATGTGCTCCTGGTCAGGGACCCTGCTCAATCACATGCTGGCTTTATCTCGTCCTGTCCTA


TCTACATGCACCTTATTAGTTCTGTGGCCTTAGGTAACTTTGTCAGTTTTCATATCTTGCAAAGTAGCTGCATTAAGGACACAGTGA


CACTTTGCGGCCTGGTTTGTGGTAAAGGCTCTGTCCCTGCCTGCTGCCACTTACAGGTAACCACGATGACCCATCCTTGCCCACCTG


GCCCTCCGCTCACTTTAGCTTCTTCCACTGGGCACCTGCACCCAGCTTCTGACTACTCCCTCAGGAGCCACCCTGCTTCATGCTGTC


AGCGTTTGTCTCCAGCCCTACTTACCTAGGCTGGATGTGGGAGGAGCTGGGACAGATTTGCTTGGTAAGGTGCCCCTCCCCACCATA


CCCGGCTCTCTGTAAGTCCTCATTGAGGAATTACTTTATTGACCTTTGGGACTTATGACTGAAGATGATATCTACTCATTTGACCTT


TCCTGCTCCAGGAAGCTGTGACTTAAGGATCATAAATAGGCCAGGGAGGGTGTGTGCCCAGTGCTTGGGATGAAGCCGTGTGAGGAC


ATCCCTTCACAGAGTGGGCTCAGGCCCCTATTATACACTCGCCTGTGTCCAAGACCCCTTGTGGTTTTCATGTCACCCACAGTTCAC


AGGGTGCTTTTCTACCCTTATTACCTCAGAGTCTCTTGCAGCGTCTCTGCAGCAGGACAGGCCGTGTTGATTATGTCTACTTTCCGC


AGGTCAAGGGGTCACACGTGGAGGTCCTGGGAGGTAACCCAGGGAGGTCCTTCTAACAGCATATCCTAACCCTGGAGTCTGAGAAGT


AGTTGTATCCATCAGAGCTCCAGACATTAGCTCTCCAGACCTCAGGTCCCCCTGGCGGTCTCTACAGTACCGCCAGCATCTGTGAGC


CATAGCACATCTGTACACATCAGCTCTGTTTGAAGGGCTCTTTTCCCGCTGCAGCCATGGGATCCCTGCCTCGGTACCCCATGGGCC


ACTTGAGCTTGAGACCTCAGGCAAGCCCATGCAGAAAGGACGCCTGCTGTGGCAGTGGCCGAATTGGGGCTGTCAAGTGGAGATGGC


AGCTCTGCCTGCAGGAGGAGGCCTCTGTTCCCTCTGATGAGATGCTCCTGGCTTCTCCCTCTGCTGGCTGGCCCAGCTCTGACTGGA


AGAGCCTATCTACCCTGCCTTGCTCTCTCTTTGACTGGGTCTTCCAGAATGGTGCAGTCAGCATGTGAGTTCACTGGCACGAATCTC


TTGGGGAGGCTGACACTTGGGCCCCTTCAGTGCCATATACGTGTCTAGTGAAACAGAAAAGCCAGATTCTCAGTCAGTGGGTTAAGT


GGAGAGAGAACAGAAGCCACAGGCTTGGCTTCAGTGCCAGACTGTGCACACTACAGCCCCCGCCCCAGCTCCAGCCTAGACTGTAGG


AGGTCAGTGCTTGTCAACTTTCTGGTCTTAGTATTGCTAACTTTAGCTCAGAGGACCGTAAGGTAGTTTTGTTTAGCTGGCTTATAC


CTATTGATCTTTACCGTATTAGACATTTAAGATAGAAGATTTTAAATGTTTACTAATTATTTTAAAATAATTTAAAAACTATCAAGT


GTTACCATAAATAAACATTCTAAAATAAAAAAGATAATTGTGTACTCTAAGACAAAAAATATTTACTTAGGAAAACCTCACTGTTAA


TTTGGAGCTTCAGTGTGGCTGCGTTCAGCCTGTTAACAGCGTTACAGGTTGTGAACCCTTCAGGAAATGACACTGTATGTACATAAG


AGAAAGCATCTAAATAAGGCAGATAGTTCTGGTTTTGAAACAAGACCTTTACTGTATAGCCCTGGGCATGATACTCTATAGAGCCCA


GCCTCTCCTAGAACTTGCTGCAGTCACCCTGTCTCAGCCTCCCAAGTGTTAGGATTACAGGCAGACTCCACACCCCCTCCCCAGTCT


TAGTATTGTAGGAACTACTAATTGTAGGCTTTATTCTGGTGGACTCCCTAAAAGGTTCTCAGTGATTCCCTCTCCCCCCAAACACAC


ACACGCGCACGCATGCATGCACGCATGCACGCATACACACCCCTCTGGAGCACACATGGAGAATCTCTATGTTGGTCTAGTATCACT


TTCCTATATGAACACATCACTCCCTCCCCAGCCCCCACCGGTGCCTTCTAGCTTCCGTATCTGTAGGATGTCCGTCAGGAAGGCTCC


AAGTTAGACTGGTTCGATCCTGTTGCCTCACATAAAAGCCTTTTACTGTTTCCAGGCCTCCTTTTCCTCATTCGTGCATAGAGATGG


GTATTTTTTCCAGATGGGTGTTGCCAAGTTTGATGGGACAGGAACTGATCTCTGGCCCCAGCACTTCCAACCCAACCCCCACTGAAG


GATCGAGAGGGTGGATAGACTCGGATCTGGGTCAGTCTATAGGTTCCTGGGTCAGTCTAGGTCCCACTGAAGGAGCTAGAGGGTGGA


TAGACTCGGATCTGGGTCAGTCTATAGGTTCCTGGGTCAGTCTAGGTCCCACTGAAGGAGCTAGAGGGTGGATAGACTCGGATCTGG


GTCAGTCTATAGGTTCCACTGAAGGAGCTAGAGGGTGGATAGACTTGGATCTGGGTCAGTCTATAGGTTCCTGGCTCCGGTGGTTGA


ACTGGAAGTCTCGGGACAGGCACCTGTGGAAGGCAAACCTACTAAGGGTTCGTAACAGGCCTGGCTTAGGAAGACAAATGCCTGCCT


CTTTTGGCTGCCGATCCCAGGGGTCTGAAGCACCAGACACACAGGGGTGGGTGCTGACCCTTTGCCTCTCACCAGATAGGCTGAGGA


GCTCTGGCTACTCTATCCTAATAGGGGCAGGTGGGTTTTACAGGCTGTTAGCCACCGGGGTTTGAGTTGAGTCCCACGCTTCCCCTG


TTGGATGCCAGGGCTGCTCTGTGCCTTGGGATCCCTGATTCATCATGGTAACCTATGTGAGCTCTCCCCTTAACCCTGCCTGCTTAA


ATGCCCTGGTTTTGTTTTGGTAAGTGCTCTCCTTGGACGCTTACCCTGTGGGATTTGGGCGGTCTTTGGGGTGGTTGCTGCTCCCGT


TTCTCTCCATCAGCCCAGCCAGCAAGGGTCATAGGAGCCCAGCCCCACCTCCCTGATTCCTGTCAACGCCTCTGCCAGTTCCAGTTC


TCTGCTTCCCCCGAGCAGTGCTAATGACCCAGGGGACATGCTTCACCCACACTCAGCCTGGCCCAGCCTAGTGCTTGCTCACACAAC


ACTCGAGTCACCTACACTGAGGCCGCAAGTTCTCCATATATATATAGTTAAAGCCCTTTCTAGTGTTTTGTTTTATCTGATTTGGCT


TTGTGTGGCTTTCCTTCCTTTTGTACTAATGTTTCTCTCTGATCTTATTTGCATTCAAATTACCTCGCCAGGTGGTTCACCAATCAG


AGGTAAGAATGCTGTCCGTGCATTTCGCCACGCCACGCCACGTCACACCACGCCACACCACACCACTACTGTCGCCGTCGGTCACCT


CCACTCCATCCCGTCCAGTCCGTCACCTCCCCATACCCATCCTGCCCTCTCCAGTCTCTTCATCTCCAGCTCCAGCCCCTTCTGCCA


CCAGCCACCACACACCTCCACTCTCAGTCATTCCCTCCTGTGGACTCATCCATTATAAGTCTGCATTGTGGACATAACCAGCTGAGA


CCACCCAGGATGGCAAGCCCTGCTACTCAGGCTTTCTAGGCTAGTCCCACAGAACGGACCCATTTGGTTCCCATAGCGAATCCTAGC


CTGAACCTAAGGCTGGCATAGGCTGGGGAGCATGACAAGTCTGGCCCTTTCCCGTGAGAGTCTCCTTTTTCTTAGGATAGTTACCGC


TTGGCCTTTCCTGTAGTATTTTGGTCCCGTAGTCAGATGAGGATCATCCCTTATATCTCTTCAGCAGCAAGGACTAGGATCTTAGGT


GGCAATTGGGAAATAAACAGACCCATGTATAACTAGGTCAGCTGACCTGTCAGCTTGCAGCCCCCCAGAACTGCCTTCACACGACAG


GGTCCTGCAACCTACTGGTGAGAAAGCATAGATTCTGGGCTGATAGAGGTCAGGGTTCAAGTCTGCCTCCTCTTAGAACTAGAGCCA


GGACCACCTCCCCTCAGGCTGTGTGACCTACAGGAGACCCAGGACGCGTATGGACAGTTTGTCACATACAAAATGTAGTTTGTGTTT


CTATGCCACTATTTTCTTCCCATATTCGTCAATATTTGTGGGCACATCTTGGCCCTCTCTTGAAGGCTAGAGAGCTCAGGAGAGAAG


CTGGGGCTGGGGAGTAGCTATTTGTCCCTCTGACACCAGGACTCGGTTTCCCTTCCCTCTCTGCCTCTCCCTGCACATCCGTCTCCT


TAGCACACGCCCACCCTGCTCTCCCTGCTACTGGATCTGCGTGTCGGTACCAGATTTGGAGATATCTGTGTGCAGATAGATCCAGTG


TCTGTCCTGGGTAATGTCCTAGTTTCCTTTTTATTGCTATGATAAACACCATGACCACAGGTGACCTGGGGAGGACGGGGTTCATTT


GACCAGCATGTCCCAATTACTGTCTATCACTGAGGGAAGTCGGGGCACGGATTCAAACAAACAGAGAAAGCCAGTGGAGGAGAGCTA


CTTACTGACTTGCTCTCCTTGCCTTGCCCAGCTTGCTTTTTTCTCTACACCCAGGACTACCTGCCCAGGGGTGTTTCCACCCACAGT


GAGCCTGGCCCTCCTGCATCAATTGCTAATCAAGAAAACATCCCACAGACTTGTCTACCAGCAAATCTAACGGGGGCTTTTTTCTCA


ACTGAGAGTCCCTCTTCTCTCATGACTCTCATGGCATGTGTTAAGTTGATAAAAATAACTAACAAGCACAGGTCTCCTAAGCAGACC


TAGGCTCTTGTCCCAGGGGAGCTTCCTCCGTCCATCAGCTACAATCCTGGGCACTCTTTCCCTCAGCTTGTGGCACCAGCTGCCTGT


CTATCCCCTTACTTTTCTTGAGCTGACCATGGGCACACTCCACCAGCCAGGGCCCTGATCCTCACCTGTTTGAGTGAACGTCTGCTA


TAACGGTGTCCATTCATTTCATGAATATGACCCACTGGCTGCCAGTCAGCACCGTTGTTGCAGTTGCTGGGCATTTGCCTTGTGCTC


TGATGTCCATGGGGAGGCTGAGGTCAAGGCTACGGACAGCCAGCCCTTTTCCTCTGTGTTAGTGGCTCGCGCACACACTCACACACA


GAGCCACCACCACCACCCTCAGCCTTCTGATGTGTACAGCTCCTGCTGCCATGGTGCTGATGGTGGAAGGGGGAAGAACGGGGTTTG


AAGAAGCTGAAGCGTGGACCCAGAGTGTCTCCCCGTGGGCCTGGGCTGTGAGGACACAGCTTGAAATTGCCTCTGAGGTTCCTGTCC


AGTCCAGTTAGGTGGGACCTGGCAGGTTCTGTCTGTCCTCTGTGGGCGTGATTGTCAGTCGGGGTGGAAGCAGAAGCTCTTTAGAGC


TCTTCCAGCTGTTCGTGAAGGAGGTGGTTTTCTGTCAGACTGTGTCCTGTGGGGGTTATTAGCTGTCCGTTGGACTGTCCTGTGTGG


GTGTAATTGTCTGTCAAATTGTTCATGGGAGGGGCGTGGTGCTTTGCCCTGTGGGTTTCTCTGTCATAGATAGCTATCCGTTTGCTT


TCACTAGCAGTTTCCAAGTGTTTATTGCTGGGGGGTGGGCTGGCATCAATGCAAATGATCCTTCACCTTGGGGTCACTCACTTGACT


TGACATGGCAGTGTGGGTCCCAAATGCAAACTTCATCCATCCTCTCAGAGGGTCCTTTCAGCTACCCCCACCCCCAGCCTTGGCTCC


TGTCTGTCCGCCTGTGGCCAGGAGCAGCCCCTCAGGGCGCTGCCCCAAGTGGGAGCTACAGTCTCCATTAGCCTTGTGAATTATGCA


GCAGCCTTGGTGGGTCGAAGCACTTTAGCAAGACCAAGCCGAGGAAAGTGGCCGGAAAGGGTGGGGCTAGCAGGGTGGAGGCAGAGT


GGGAGACGATGGTGGGAGTGTGGGGCCGACGCTGCTGAGCGGCCAGCCCCAAGGCAAGCCCCTTCCTTCCTTCCGAGTAGATGATAG


TGTCTCAGGCTCTTGTTTGATGAGGACATTGCTTCTTTAGGAATTCCAGACCTATGGGGTCTGTAGGCTTTGAGGACAAGAACATTG


ATAAGCATGGTTATTGGCAAATAGCCTTAGGACTCACTCGAACAGTGGTGGACGCTCTATGGACAGCCCCTGGGTGGATCTTGCTTC


TAAGTACAAGTTCTTGACTCTTGCTTAGAGGGACCTGGCTCATCAGAAAGAACTTCCTGAAAGCCACACACAGGCCCTAGGCTGTGG


CCCAGGAGAGCCCCTGTCGCTGGGGCTACACTTGTTGTCGAGGCTGCCGTGTCCCAGGCCACACGCACCATGGACCGTGACCGACGT


CTTCTCTTGTGTCCCCCCCACAGGTGCATTGCAGATAGAGAGCAGCGAGGAGTCTGACCAAGGCAAGTACGAGTGTGTGGCCACCAA


CTCTGCAGGCACACGCTACTCGGCCCCCGCCAACCTGTATGTGCGAGGTAAGAACTTGGCCACACCCAGCTCTGTCAGCTTGGAGCC


AGGCGTCACCTGCCAAGCATTGCTGCCTAGAGGAGACCTTGGTGCAAATACTGGAGGGACTCCGAAAGTCTTTCCTTCCCATCTCTC


TCCGCAGCAGCACTAACAGCCACCACCTCCATAGCTCCCAGGGGCCATTCTACTAGCAGCCGCCACGACTTGCCTTCTTTCCCTTCA


GGCCCTTGGGGAAGCAGACGCTCCCTCCACCCTCTCACCCTTGGGAGCATTTGTATCTCTTGTAGGTCTTTGCTGCCCGGTCCCAGA


GCCCTATGGGAGTCTGGAGCCTTCTGAGCAGACATTGCTGTTCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT


GTGTGTTGGTGTGGTGGGGTGGGGAGTGGGCACACAGACACATGCAGTTACATGTGAATATGCATTTTTGACCTGACTTTCCCTCCT


GCTACTCCAGCAGGCTGGGCTCTAGGACTCTGGTTCTAAACTTTAAATCTGGCTCAGGAATGGCCCAGATCGGCCTTCCGGGAGGAG


CCTGCTGTGGTCTACGACCAACTCCGCCCCTCACGTTGCGTGAGGCTGAGGTAGCTGAGCCCCTATGGGTATATTGCCTTGAGCATT


CCTAGTTGGGGCGAAATGGACTGGGGGCTATTTACAGTATTTACAGTTCGGTCCACAGCTGAAGGGTCTGGGACTGTTTTGGTGTGT


CCAGCCTCTGTTTATAGCCAGAGGGAATCAAAGTTGGCCGCCTGGGCCTCCCTGAGACCATGAGAGATAGTCGAGAAAGATGGATCT


CTCACTGGGGATGGCTGAAGGAAAGAGACCAAGCTTCCTTGTAGCTCCCTGCAGTAGTCACTCCGTCCCTTAAAAGCTTCCTTCCCT


CTTTCTGAGGATAGTATGACGTCTCTCCAACTCATGGAGCCCAAGTGATGGCAGTGGCCTGTCCTGTCTCAAGGCAGTTCAGTAGAC


TTGCTTACCCAAGGTAGAGAGGTGCAAGCCACCAGCTGCTTACTGAGGGCCAGCCATGCCCCAGGGCACAGGTTTTGGAGGGGTCAA


AGGTGTCAGCTTGTTAGTTGACCAGAGGGGCTGTTTGTATTGGGCTAATTGTGTTCCTTCATGGGAGTTGGGAAACCCCTCTCTCTG


TCCTTGTTGCTGGGTGCCCTTGTATACCCATCAGTGAGATGACCCACGGCCAGTCTTGAGGAACACCACCAGAACAGAGACCAGGAA


CCCAAAAACTTCCTGAAGGCAGAGAGGAGTAGAACTGGAGAGAGCACACTTAACCCAGGGCTGATCCAGGCTGGGTATCTTAACAAA


GGCCCAGGAGTCTGCCAAGTCCCTTCTGGGAGATTAGCAGCTGAAAAGATTTCACAATGACTGGCCTCCTCCCCGCTCTTCAGCCAA


GGCAGCCCCTATCTACACATGGCTACAGCAGAGAGCGGAGAATCCAGCAGGGCCTTGGTAAACCCCAAGCCAGCTGGCTGTTTAAGC


ATTGCTTTATGGCCGTTTCCTAGGGTAGAGCTGCCAGAGGCAGTACCAAAGCAGGAAAAGGCCACCCAGATTCAGAAAGGATGACGC


GGGGCATCCTAGCTAGGCACCACACCTGTCCAGCTCGCACCGACATGCTGGCTGTGGCCAACGGCGGGGCCATGGTTATCTCTGGAA


ATGGACTGAGGTGGCTGCTAAGGCACTCCTTGGAGCATCCCTACCTGCAGAGTCCCCGCTGTCCACACATGATTGACTTGGACATGA


CCCTAGCTGGAGCCTGCCTTCTCCCACCTCGTGGCATAAGATCCACTTGGAAGAGCTTTGGGAGGTCAAGGGCATGGGAGCTTCTTT


ACCCATTTTACGCTCAGCCCTTCCTGCCTAGAGCCTAACGTCGCCAACCTGGCTTCTATAGCTCACCCTCCAGGCCCTGCCTCATAT


CTAGAACCCATCTAAATCTATGAGGGACCTTTGATTCTCGGATCTGTACCGTAAGGAAAGCCCTGCTCACTGAGACCCTGGCCTGTA


GTGTTTGCAGCTTCCTTTTGTGCCTAGCAAAGCCCCATCAGCCCCAGGAGTGCTCTGGGACCACCTTGTGTAGTAGTACTAACTACC


AGCTCTGTATTTGTAACTCTGTATGTGGGTGGCTAGGGATGGAAGAACCCCGCCCCACTCCAGTGCCTATCTGCTGGACTCTTTGTC


TCCCAATATAGCAATTTCAGTCCATAATGGTTCCTGTTATCACCCAGAGATGGAAGTCCCCCAACTCTTGTCAGGCCTTAAGCCTCC


TGATTCAGGCTAGTATGAATTATAGCTCAGATGTTTCTTACCCTTCGGACTGTTGACATTTTAGACTGAATACATCTCTGTTGAGAG


CCATTCTACGCATAGTAGGATATTTAGAAGCATCCCTAGCCAGTCAGGAACCAGTAGCAGCACTTAATAAGACCAGTCTAAATGGCC


ACAACTCTCTCCAGACGCTGGCACCCAGAGGCAGTTTGCCCCTGTGGATACCCTTTCTCGGGATTGCTGCCTCCTGAGGGCTTCTGT


CTCCATCTCTAACTTTGTTCTTCTGTCTAGTGACTCATCTTCTCAGACTTAGCCTCCCTCCTCACGTCCTTCCTCTGTTCCCCAGAC


TGTCGGGGCTCTCCCTGCCTCTCTGAGGCCTTAGGCTGCTTCAACCGATGGGGCAGTGCATGGGCATCAGAGCTTCCCGCATGCTGC


CAGGAGCACAGGAGGCGCGTGAGAGTCAGCTGTCTGGGCTCTGTTGGGCTAGCGCTGGGGCACACACATCGTGCAGTCACAGCTGAC


TTTATTCACAGTTGCCTGCAGTTCCACCCACCGTCTAGCAGGCCCAGGCACGCTGGGTGGACCAGCCTCTTTCTCCATCACCATCTG


ACTCCCTCCCTGAGTGACTCACTCTCTCCTTCCATCCACGGCGTCTCTCCCCTCCGGCTCTCAGGCATACAGCTTCCCGGGCCAAAG


GCAGAACTCTGCCCTTGGCAAAGCTTGCCTTACCTGTACCAAGATCACCAGCCTCTCCGTTCTCTTCAGGAACCCGGCATCTGAGAC


TCAGCTGTATGACTAGAGGACATTTCCTCTTAGCCTTTCTTTCCACAGGCATCCGGGCGTGCTCCTCACACTGGTGTTGGCGAGGCA


TGGGGCTTCCTCACAGTGGTGGGGCTGGAGTGGCTTGTGTGCCTCGGTGGGTTTGTGAGCTGGGTGGACCCTGACCCCAGAGCCTGG


TAGGGTCTGTCTGAGCGGTGAGGGTGTGTGAGGCATGGTGACTAGCCCGTGCCCCACTTCTACCCCTACCTGCTCTGCCCTCATCGT


CCCTGGCACTGCTGGTGGGCCCTACCCTGTCCACTGTGTCTCTCCATGAGTCCTAAGTCCTCTGTGAGCGGCGTGGTCCGTGTGCAC


CTGTGTGCACGTGTGTGTGCGAGGGGCACAGGAGTCCTGTCTTGTCTCTGTGCTGTGTGGGCAGATGGAGGTTGGCCTGTTTTTACT


CTCTCTGTGTTTCTCCTTGTCTTTTTTTATTCCCTCTCATCCTCATCGCACTCTGCCATCAACCCAAACTCTCATCTCTCAGATCAG


CGAGAAGGTTGGTCGTTTTCACTTCTTATCCATCTACAGTTCGCCCACCGACTGTGCCCATCAGTTGGGACCAGCGGGCTTGGTCGG


CTCCCTCAGGCTCACTCCAGCCGCGCCTGCCCGCCAGTTGGCCTCTTCTCGGTGTTTGGGCTGGCTGGCAGGCAGGACCAGGGATGG


GTGGGCAGGCCTTCTGCCCTGCATGTACCTGTTGCTTGACCCTGATTCGCTGTGTGTCTGCATGTCCCCTTAGCCAGGCTCCGCTGT


TGGAGTGGCCACACATGCACGGTGCACCGCATAAAACTGTACCCTACAGAACTGCACTCAGCTTTGCACCCAGACCAGGCTAGCCCT


CTGTTTCAGGAATGGTCATGGGGATCTCTGTCAGAGAAACTAAACTACATGCTTGGCATGTAGGAGTTCAGGGAAGCTTCTACCATT


TCCCCACCCACCCTTATGTTGTCTGCGGAACTAAGAGAAGGCAGAACTGCAGGAGGCAATAGGAGGAGGCTAATTTAGAGTGAGTTG


TCCCCTTGAGATCTCACAGTACGCGACACAGTCCTGCAGTGTCTGCCCTGCCCTTGAGGCCCCCAGAGCCTTACCAATGCTCCACAA


AGCAGACTGGCTGTACTGAGACTTAAGACCAGCCTTGGTCTGCCTCTCAAAGACCCTGATGGCCGTAGTCCAAGGCAGGTGGCATCA


TTTTCATACACTGAGTAAGTGTCCCGACATTATATCTTTTCTGTCTCCTACCAGGTCCAAACCAAGGTCACCCTGCCTGCCCAGACC


ACTCTACCCGAGCTTCCAAGCCAGCCTCTGTGCCTCTCCGAGGGTACAGTGTATGTGGCTCACTGACCAGCTAACAGCCCTCAGTCC


CATGCTGGGCAGTGGCACTGAGCGTTCAGATCCAGTTTGCTTATGCCTGGAGTGACTGAATTGTCACTGCAGTCTCCTTAGGCCTTG


AGTATCAATCAGTCCAGCTCAGCCTTAGATTGGGCAGGGCTTTTTGAAACTCCCTGGATCCTCTCCCAGAGCTGTCCCCTGGAGCCA


GGCCTCTATTTCCCAGTACTGGACCAACAAGGGGCTGGTGGTCCTTTATATATCGTGTGGTGTAAAGGGTTAATCACTGGGCTTTGG


GGGGTCCAAGGAAGAAGCACAGGGCAGACCCCAGCTCCCAGGTGGCCTCTGCATCATGCTCTGTGGCTTTGAGTTTACTCCGGGAGG


ACAAGGGAGCCAGTCAGGAGGAGGGCTGCAGCCTGGGCTCAGATATCAACATAAGCCTCCATCTGTATGCACTCCTGAGCTCTGGGG


CATTTCGGTTACACCATTTCGCTGACCAGGCGGATCTGCCAGGGCGTTCAGAAAATAGTCATCAGCAGACAGCCCAGCCCGCAGCCA


CTCCCCCCACACCCCTTCACCTACCCTCTGCATCCTTTGTTCTCTCCCCACCCACCCTGTGGTCCCACCAAAAATACACACATACAC


AAATATTTAACGGGAAGGAGAAATGAGTTTCTAAATATTCCGGGGGGATTTGCCGGGCTGGTAATTTGTTTGGTGCTGATAATTGCA


TCTTACATTTTTCTAGCTTTACTTAAAACTGTGTGCCGGGTGTGCCAGCATTTAATTACTGCTCTGCGGCAGCCACAAGGTTATTTA


TTAAAGAGTTATTTTATCTTGATACAGTGGATCCTGCCCCTTATCCCCTCCTTAATGTTGTGTTATTTTCATCAGAGAAATTTCCGC


AAGTGAATGCAGATTGCGGGGCTACCTCCCCCTGCGATTAGGCTGTCACTCCACTGAATGCGGATACCTCCAGGCGCCGCACCACCC


TATTATAGGGGGTTGTCAGCGCAAATAATTAGACTTAAAAGTTACAGCTGAAATATAATCCAGAAATGGCAGGGCCCTGTTTTGGAA


ATTGTCTATAAAATGTCAGCAGTAAGGATGCACGGGGAACAGTAATAGACCGGCATTGTTGGAGCCTGAGATTAGACCCTAAGTGCA


TTTTCCCCAGCTCCAGTTTTTCCTTCCCTGCTGTTGCTTCTGTCAATAGACCAAGTCCAGGGAGAGTCCTGTTCCCTTTGGAGGCCC


TGTGCTTGTGGCAGCCGGGGGAGGACGGTGGAGATGCTATGTTGGAGCATCAGCCACTTGCAACTGTTGGCACAGGAGTAGCTGTCT


AGGCTGGGCTAGGACACAGGGCCTCTAGCATTTGGGGCACTTTGTTGCCTCTTTCCCCATTTTCAGTAGATATGCTGGCCTACCTGA


GCTCTAGCAGATTGAACTTCCAGGAGTCTTTGCTGTGGCTGGACCCCAGTGCCCTTCTATAGGAATGTAGTTATCAGTGGAATACCT


GGGGCCTCTGGCTGAGTTCCTTTCCCAGTGCTGAGGTGACCCTGACCTCACACCTGTCTGTAGCCCCCAAAGTTCTCCCTATAGCTT


GCATCTTGGAGGGAAAATAAAAGCCATTCTTAGCCGGGCGTGGTGGCACACGCCTTTAATCCCAGCACTCAGGAGGCAAAGGCAGGG


GGATTTCTGAGTTCGAGGCCAGCCTGGTCTACAAAGTGAGTTCCAGGACAGCCAGGGCTATACAGAGAAACCCTGTCTCGAAAAACC


AAAAAAAAAGAAAAAGCCATTCTTAGTGTCACTTCCCATGGGGGCCCAGTTTCCTGACATCGACTAGAGATGGAGCCTTTGAAAGGA


GCGGCCCAGGGCATTGGCCTGGCTCCGAAGCTGATCCCTGAGGACTCTGCTGGCTTGGAAAACACTGTCCACCATGGACTATCCAGG


GGTCAAAGTTTGGACATGTTTAGGTATGGGCCCCAGGTATTTTAGCCAAAGACCTACTTCCTACTGCATAAACCCAGTGGCCCCTCT


TTCATTTGGGTTCCACCATTAACTAGAGCCACCATTAACTAGTGTCACTCTCAAAAGTCTTATCTGTATGCCATCTGGAGCTCGACA


TTATGCCAACGCTAAAGCCCCATGGCCTTCATGGGCTTTCGAAGATAGAGTTTTTACCACACAGACCTGATCTTCCTGAGGATATAA


AGGCAGATGCGTCACTTCCTGTGTCAGCATTGACTCTGGCCCTCATCTGCAATTGAGACATGGTGGCACAGGCACCCTCTGTACAGA


GTACAGAGTGGCTTTCCACTAGGCATGATGTGCATGGCTTTAATCCCAGCACTCAGAAGGCAGAGGCAGGTAGACCTTTGTGAGTTC


AAGGCCACCCTGGTGTATACACTAAGCTTCAGGATAGCCAGGGATATATAAACCCTGTCTTAAAAAAAAAAAAAGAGTGGCTTCATC


AGTACATGACTGCATGCCCTTCAATGAAAAGGAAATGACAGAGAGGCTTGTTCAGTTCCAGCAACTTCTGTGTTCTGAACTCCTCCA


TTCCTTGCTAGGCCTGGACCTGGCTTACATGCAGCACTGTATACCTGTTCTTCACCTTGGAGTGCTCAGCTATTAGACCTGGTATGA


AGCCCAGGAGTGCCCATGCCCTGGGCTGGCAAAGCCTGCCTGTACCATCTGCCAGTTGAAAGTTCTTGCAAGGGAGTCTGTTACCAT


GGGACACTTGGTAGCTATGATCCCTGGGATATACCTGTCCCTTGTCATGAAAACTGTGTCTGTGATACCGTGTCATCAGCCATGTAG


ACTCCTGATAGTAACATACATGATGCCCGGCAGTGGTGGCACACACCTTTAATCCCAGCACTTAGGAGGCAGAGCCAGGCAGATTTC


TGAGTTCAAGGCCAGCCTGGTTAACAGAGTGAGTTCCAGGACAGCCAGGGCTACACAGAGAAACCCTGTCTCAAAAAACCAACAACA


AAAAACAAAAACAAACAAACAAAAACGAAAATCCATACATGATAAAAAGGCTAGGCATGGTGTCATACACTTAATCCCAGCACTCAG


GAAGGGGGCTGAGCTGAAGGCCAGCCTGCTCTACAGAGTAAGTTTCAGGACAGCCAAGGGTATACAGAGAAATACTGTTTTGAACAA


CAACAAAAAGCATCAATGATGAGGGGTTTGGAGAGAAGGGTTAAGAGCATTTGCTCTTGAAGAGGTCTATGTTCAGTTTCCAGCACC


TACATAGTGGCTTCCAACCATCTGTAACTTCAGTTACAGAGTCTCTAGCATCCTCTTCTAGCCTTCGTGGGTTCCAGCATACATTTA


TGATTGTGCAGGCCTACATACACATACATTAAAAAAAAATTAGGGTCAGAGATTTGGTTGAATGGTTAAGACTACTTGTTCTTGCAA


AGGGCCCAGGCTCAATTCCCAGTTCCATCCTGAAAGCTCACCACATCCTTGGGTATCAGGCACCTAGAGTAATAATAAAATAAATCT


TTAAGTGAATAATAAAGTAAGTTTTGTTGGACAGTGGTGGCACAAACCTTTAATCCCTTCACTTGGGAGGCAGAGGCAGGTGGATTT


CTGAGCTCAAGGCCAACATGGTCTACAGAGTGAGTTCCAGAACAGCCAGGGCTACACAGAGAAATCCTGTCTCAAAAAACAAACAAG


AAATAGATACGTTTTTTTCAAAAGAGACTTAGGATAAACCCAGGTATGCTAGACTAAGCAAAATAAAGAGTCTTATGATACAAAACT


AGGAAGTGTAGAAATAGATTCGGTGTTGGGAAGCCCTGGAGCCAGGTCTTCAGTGTGTTCGGGCCGCTGCTCGCCATCGCCTCGCTC


TGTTCCTCCACTGCTCTTACCTTTGTACTGCAGCCGGTCCTCCCCGGCCTTAGGAAAGGAAACCCTGAGCTCAGCTGCCCCTGTAAA


GTGTGTTGCTGCTCTCACCGGCTGTGCAAACATCCAAAGGTTGCTTCTGGTGCAAAGGTTGTTACTTATTAGCCAGATCTAGATTAC


AAACCCCGTGCCAAGGATGGAGAGATGGCTCCCCTAGAGAAAACAAAGATGGGACTGGAAATGTTGCTCAGTGGTAGAGTACAACAC


CTAGCATATATGAGTCTCTGAGTCTTCTTCCTCTAAAAGAGAGAGGAAGAGAGGCCTTGGGGGGGGGCGGGGAGGAAAGAATGAGGG


TGCTGCTCTTTCAGGCCAAAGGTGGAAGTCTAGACATGTACAATGCACTCCAGGTAAATGTCTGCCGTGAGTTTAGGGAGCAGACCC


AGCCTGCCTTTCGCTGTGACTCACTTGGGGCTGCCAGTGTTGTGATCCCACCCAGGGCTTAGGGAACCTGGCATAGAAGGTGTGGAA


GCAAGTTCTACCCACGGTCCTGTAGGCTGGCCACGGAGCATCAGGAACCACACAGAAGCTTGTTAATCAGGGGCCGCCAGTTGTCTG


TGCAGAGCTTGGGAGTTGGTTAGGGTGAGACGTTAGAGGGAGCGCAGGAGTGGTGTTATTTAGATGTTACTAGTAGGGGTGATGGAT


TTTTTTTTTGTACCCCATTTTTTAATAGGGTTATGTGATTTTTCTGGAGTCCAGCTTCTTTTTTGTTGTTGTTGTTTTGTTTTGTTG


TTTTTCTTTTTTGTTGTTGTTGCTTTTTTTTTTTAAATTGGGTATTTTCTTCATTTACATTTCAAATACTATCCCAAANNNNNNNNN


NNNNNNNNNNNCCCTCCTCCCCTACCCACCCACTCCCACTTCTTGGCCCTGGTGTTCCCCTGTACTGGGGTATATAAAGTTTGCTAG


ACCCAAGGGCCTCTCTTCCCAATGATGGCCGACTAGGCCATCTTCTGCTACATATGCAGCTAGAGACATGAGCTCCGGGGGGTACTG


GTTAGTTCATACTGTTGTTCCACCTATAGGGTTGCAGACCCCTTCAGCTTTTGGGTACTTTCTCTAGCTCCTCCATTGGGGGCCCTG


TGTTCCATCCAATAGATGACTGTGAGCATCCACTTCTGTATTTGCCAGGTACCAGCATAGCCTCACAGGAGACAGCTATATCAGGGT


CCTTTCAGCAAAATCTTGCTGGCATATGCAATAGTGTCTGCGTTTGGTGGCTGATTATGGGATGGACCTCTGGGTGGGGCAGTCTCT


GGATGGTCCGTCCTTAGGGTGATGGATTTTGAAAGCTGTCTTAGGCAGCCCTTAGTACAACCCCGGTGACTTTTACTACATGTCTCA


GCTCTAAGCCTCAGTCTGACCCCTAGGAATTGAGGTGAGATTGAACCTTGGGTTCTTTCTTGGGATGCCACCTCTGCTTCTGTGACC


TGGGACTGCGTGACATGCTTCTTACAATGGGTCCTCTGCATGTCCGGACCCCCCAGCAAGAGTCCTCAGAGACCTGTGCTCTCATAG


TGGCCCTCAGGTCACTTGGGCTTGCTGCCTGTCCTCTCTGGCCCTTTGTGTAGGGTGGCCGTCTAGGATACACATGAGCCTCTGCCA


GCAGCTGCATGACCTGCCTGTGTGCCAAGCATGTCTCTGTGTAGCTAGCTCTTGTCCACCTTACCCTTTCTGCATGCTCTGAGTGTC


TGTGCCAAGCTTGCCACTTCGGGGTTGGTTTCCGGCTTTGCCCTGGACTGAGAAGCCCAGGACAGCTTCTGGCCAGGGGAGTCCAAG


GCTGAGGGTTGCGGCTAGGCACAGCCACCTCCCTTGAGAGCTTTACTCACTGGTGCAGAAAGCCGTCTGCTCGGCCCCCTCATCATG


TTACTGCCATCCTCATGCCCATCCTGCCCGCGGACCACGTCCCTGGCCCGCCCAGCCCCTTGTCCCCGGACTAGCCCTCCTAAGGCG


CCATCCACATTGTGGGTCCCAGGCTGACCTGCATAGGCAAGGCCCAGCAGGTACTTGTGCCATTTTCTCTTCTCTCCTGGGGCCATG


GCCTAGAGGTGGAGACACTGACTCCAGAGAAGGTTGCCATGGTACTCCCAGACTGATCCTTTGCCCCACCCCCCACCCCCAGCCATG


CTCTGAGGACCTGGATTGCTTTCATTGATGGTCCCTCTGGAGACACAGGAGGAGGGGAGTCAGGAATAAACAAGGGTGGTCATTGGA


GGACCACCTGGAGTGTGGCCCTAACCAGGCCTGGCTCTTGCATTAAGTCCTGTGTGACCTTGGCTGAGTGTCCCATGCCATAAGATG


GGAGCTTGGTTATGCAAGTTGTCATTAAGAGGTGTTCCAGATGGTCCCTGAGTGCAGGGACGACTTCTGGAAAGTGAGGTGGGAAAT


GGTGAGCCAGGCCCCAGGGACGCCACTCCTCCTGTCTCTGAGCATGGGCTTGGCTCTGACAAGAGAGGCTTCCTTGATGAGGGGCCC


CTGCCCTTCTGTCCACCCTTGCATCCCGCCCAGCCTGTGAGTGCCTCTCTCCCTCCTCCCACAGTGCGTCGCGTGGCTCCTCGTTTC


TCCATCCCTCCCAGCAACCAAGAGGTGATGCCGGGCGGCAGCGTGAATCTCACATGTGTGGCAGTGGGCGCGCCCATGCCGTATGTG


AAATGGATGATGGGCGCCGAGGAACTGACCAAAGAGGATGAGATGCCAGTTGGCCGAAATGTTCTGGAGCTCAGCAATGTCATGCGA


TCTGCCAACTATACCTGTGTGGCCATCTCTTCATTAGGCATGATAGAAGCCACCGCCCAGGTCACAGTAAAAGGTGAGTGTAGCGGT


GCCTCAGCTAGCTGATGTTCTCCTCTGTCTTGGGCTTTAGATCCTCAGGCCTGTGGCAGATAAGGAGGAGCTGGCCTTGAACTCATA


GAGCTCTTCCTGCCTCTGCTCACCAAGAACTGGGGACACAGCTCAGTTGATAGAGAGCATTTACCATGTTAGAAGCCCTGGATTCAG


TCCCCGGTACTGCCAAGAGGAAATCAGGCTGTAAGCTAGGATTAATCATGTCACTCTTCCTGGTCCTCTTTGGGAAGGAGCCCAGGG


CCTCACACACACTAGAGAAGCGCCTACACTCTGAGCCTTACACTGGTTCCTTTATAAAAGCAAAAGGTAGCTTTCAGGGGCTCACGT


TGCTCTGGGAGTCACCCAGAAACATTAGCCGGTCTCCCACTCTCAGTTTCCGCCAGCTACACTAAAACACACAGTTCTAGTCCCCTG


CCTGCCCCTCCTCTATCACAGTAACTGGCTCAGCACTGTGAGACTCTTCCCGTCCCCCAAGCCCCACACCCATCCAAGGAGAGGCTG


TGCTTTCCTCCTGTCCTTGTTCACAGTTACCATCAACTCATTTGCTGATTATTTTCCCAGACGATAAATTCCAGAGAGCAGGAATGT


GACCACGAGCCATTGTGGCACCAAATGGGGACTTAGTGGCTATTCATTCTTCATGCAGCGATCGCAGGCCTGGGATTGTGCCACCTT


TGTTTTGAGCCAAGTCATGGGGCCTAGTGGCGGGGCTAGCAAGTTCATGGCTCTTTCTGAACTCTAAAGGCCAATTCCTTGGGAGAT


CGTGCATGCGTGTGTGCGTGTGTTACACTTGGTACAAGTGAGAGTAGATGAGCAACAGGTAGGTCTCTGCCTAGTGTAAGCATGTGA


ACTGTGTGAGACTTGATAGGACCAGGTCTGTTTGTTGGGTGAATCACATGTGCTAATGTGACGATCCAGTGCGGGTGTGTGTGTGTG


TGTGTGTGTGTGTGTGTGTGTGTAGGTTCTAAGGGTGATGTGTTACACACCAAAGGTCTTAAGACTCCTTGGACCACCATCAGACCT


GGCTGCACTATCTCAGTAGTTGCCCTAAGAAGTCACCACAAGCTTTTCAAGCCTTTTTTGAAGGAGGGTTGTGGGCATCAACCACAC


TTAGGTGGCCATACCCTGTGTTAGGATGATGCCTTGGGTTTGTCCTCAGAATCATGATATCTAACAATTCTTTCTCCTCAGCTCTGC


CAAAGCCTCCAATTGATCTTGTGGTGACAGAGACAACCGCCACCAGTGTTACTCTGACATGGGACTCTGGAAATACCGAGCCTGTGT


CCTTCTACGGCATCCAGTACCGCGCAGCTGGCACAGACGGCCCCTTCCAGGAAGTGGATGGTGTGGCCAGCACCCGATACAGCATTG


GTGGCCTCAGCCCCTTTTCGGAATATGCTTTCCGTGTGTTGGCTGTTAACAGCATTGGGCGAGGACCACCCAGTGAGGCAGTGCGAG


CACGCACGGGGGAGCAGGCACCCTCCAGCCCTCCGCGCCGTGTGCAGGCTCGAATGCTTAGCGCCAGCACCATGCTGGTCCAGTGGG


AACCACCTGAAGAGCCCAATGGCCTGGTACGGGGATATCGCGTCTACTATACCCCAGATTCCCGACGCCCTTTGAGCGCCTGGCACA


AGCATAACACTGACGCAGGACTCCTTACCACCGTGGGCAGCCTGCTACCTGGCATCACCTACAGCCTCCGAGTCCTTGCCTTCACTG


CTGTGGGTGACGGCCCACCCAGCCCCACCATCCAAGTCAAGACACAGCAGGGAGGTAGGTAGGGGCTTTGTTCTAGATGGACAGCTG


ACATCAGAGGCTCCGGCAGAGTCCCACCTGTTTCCTCAGGCTGTGAAGTTTGGAGCTTGGGAGGGGCGAGGGTGTCATACTCCACAG


ATAGGTGGTCACTGGGGATGCACGCCAGGCTGGTGAGAGCTTGGCACCCTCTCACTGGGCCCTTGGAGGTGTTGCGAGGCTGACCTT


GCCTGGGGTGGACATTGCAGTGCCTGCACAGCCTGCGGACTTCCAGGCTAACGCTGAGTCGGACACCAGGATCCAGCTCTCGTGGCT


GCTGCCCCCGCAGGAGCGGATCGTCAAGTATGAGCTGGTGTACTGGGCAGCCCAGGATGAGGGCCAGCAGGTGAGCCAGGAGGCCAG


GAAGGGTGGAAGGGGGATAGCCCCCAGTTCCTGGTGGTCTGTGATGGGCACACCTAGGCAGGCTGCAGACCCTAGGTTTCCCTACAG


CTTTGTAGCTCTCACAGCCTATGTGGTCTGCACCACCCCTGTGCTAGAGGCAAAACTTCTAAAGTTTGCCTTTGTTCTCTTGGGTTA


GTGGCCCGTGTGATACTGTCCTAGCCTTGAAGCTTCCCCTGGGGACACAGTTCCCTGGTGGCCTTTGTGATCTTTGAGGTGGCTGTG


GCATGAGTCACGCCATGCATTTCTTGCAAGGCTGTGTGACTATGTGGGGTGGGGCTGTCAGAGAACCACAGTGGGTCCTCTGCCAGC


TGCTTGCAGCCCACGTGGGGATAACCTCTGAGTGGCCTTTGAGATCTGAGCAGTCAGTAAGTGNNNNNNNNNNNNNNNNNNNNNCAC


CGTAGAGGCCCGTACAGCACAGTCCAGTAAGTGTCTGCTAAGGCCACCCTTGTCACATCTGGGCTGGTACACTACACACGGGCACAT


ACCATTCCCTTTCAAGCAGATGGGTGGTCAGGTCTGCTGAGTCCAGTATTGGACTCCAGTCTGGGCTCTTGAGTCTGAACCCCGAGA


AAGGGACAGGTAAGTGTCCTGTTAGTCTGTGAACAGGCAGTGGTTGCCTTCTCTGCTCCCTGCCCAGCCTTCTGACCCTCTCTTACC


CCTGTGACTCTTATGTCCTGCACAGGTAAGTTCTGTGTGGCTGTGACTCATCTCTATCCTCTGTCCTTCTCCTTCCATACCTAGATC


ATAGCACTGATTTGGTGGGCCTGCCACGTTTGAGACCTGCCTAGATGCCTGTCTTCCTCCTCATGGTCTCACATCTCATCACCCATG


TTCCCCACCTCATACCCCACCACCACAGTTCTTTGGGAGTTGTGTAATCTCTGAGGCCTCTGCACTTGCGGACAGGTCCATGAGAAT


GTGACCGTGTGCCAGTGTGTGTGTGTCCCCACATCTGCCTGTGGGAGCACATGGCTTCTGTGACAACGTGACTGTTTGTAGGACCAC


CTGGAGTTTGTGTGAAGACCCAGCCAATAGCACCTGAGTGTGTCAGTGTGTGTGGGCGTGACTCTGTCGCACCCAGATTGTGATTGG


CACAAGATGGCAGATTGTAAATGTGGCTTCGTGTGATAGTAGACTAAATTCATTCTAGAAGCCTATGCTCTAGGTCTGGTAGCGCAG


CCAGAAGGCAAGGCCAGTATCCATAGGGCTCCTGCAGTGGACTGAGACAAACAGTGGTGCCTGTAATTACCCAAATGAGCTCTTAAT


TACATTTGTGCAGAGTGAGCTGGGAGGGTGGAGAGATGGCAGGCAGTACAGGAGCTACTGTTGTTGGTGCAAGGTCAGAGGCAAACA


CTGTTGGTGCAAGGTCAGAGAGAGTTCAGTCTCAGAGCTATGACACGTGACCTCCACTGAAGCTAATTAGGTAAAAAGAACAGGGAA


TATGGTGGCCCTGGGTAGGGAATATAGTGGCCCTGGGTAGGGACTCTGCAGCCACCCAAGCTGTACCAGTCGGGTAGCTCTGAAAAT


GGGCAGGTGACCCAAGATGCAGAGACCACTTAGAAACCTCTTTTGTGGACTAGGCGAAGTTTGCTGCCTTGGCTGAACTGGTCAGGG


GGTGCGGGAGGGTTACCTAGGCTACTTCCTGGTCTGGGCTTGGTGATAGATTGCAGATGCGGAGCCGTGGCTTAGAGATATGGAGGT


GCATCATGTTCCTGATAGAAGGCTCCACCAGTGCGCGCTCCCCCCAAGTCAGGTGATGCATGGAAGCAGGCTCGAGCAGTGCGCCTG


GTTTCAGGCACCCAGATTCAATCGCTGTGTCTGTCAGCGGTAGAAGTGTGGAGGTGTAGGGCCTGAGCTGGAGGAGGCAGTCCTGAG


AAGACTAGAAATGAGATCTAGGGCTGGGGAAGAGGACAGAGAGAAAGACAGACGTGGGCCTGAAGTTGCTGCTGAGTGGCTGAAAGG


GACTAGAAGTAATCAGAAAGCAGGCTTGGGGGTGGGGTGGTGGTGGCAGGCTGTGTGGTAGCTTGGCAGGGGCTCGGAGTGGATGAG


GAAGTAAGCCAGCATGCTAAGATGTCATTAGGAGCTAGGTGGGGCGCTGTAGCAATGAGGATGGGGTCTTCTTTGAAGGCGGGAACT


CTTGAAGTGCGTCCGTATGCTTTTGTGAGTTAGGAGGACCACGCTGGAAGCATGGATGGAGAGGGACAGCTGGGAAAGTCTCTGGAG


GGAGAAGGAAGGGAGCAGAATGTAGGTGAGAAAGAGCTCGGCCTTGGACTCCACTCTTGAGATTGTACAGGAAGAGGGGGGCTGGGG


CTGGAAATAGAAGCGGGTACTGTTGGAAGGCAGGCAGGCAGCAAGCTTATATGCCTACAGGTAAAGGGAGCTGGGGGTCTGGAAGCT


GTGCAGATTGACTGCGTTATTTGTAAAGTGGCAGAGTGAGCAAGATAGAGTAGATCTCAGCAGGTAGCCCAGAGAGCCCAGGGGGAG


CCCGCTGGAGATGCCTTGTCTGCCTGCCTCAGGGCTGCAGTATCCATTACCTAGTGTGGCTCAAGAGATGGTGGGAGAAGGAGGGGC


TGAGCGGATGGCTCAGCAGGTAAGAGCGCTTGCTGCGTAATCATGAAGAGTTGAGTTCAAATCCTCGGCACCCACATAAACAATAGG


GTATCGTCATATATGCACCTTAGCACTAGGACTGTTGGGAGGCCGAGTCAGGAATCTGTGGGGCAGGTGCCCATACTCACATATACA


TACACTACACACACTTACAGAGATGAGAAGTGAGTTTAGGGCACTGGTGAGAATGGTAAGCCAGGGTGCTTTTAAGTCACGTCTGAA


TATTCAGGGCTGTAAGGATGGAAGTAAGTGATGGGATCCCCAGGAGTAAGAGTAGAATGCTGGGGCCCAGGGAGACCCAACTGGGAC


AAGAGGTGGGCGCACAGGGTAACGTTAAAGGTCATTCCCAGTACTGGTGTGGTGCTTAGCCACCGGTGAGTCAAAGGCTGTTGAAGT


TACCCAGCCAGTGAGTGGCAAACTTGAGGTAAACGGAAGCCCCTGGATTGGTAGTGGCATGGTGTCACCAGGCACAAGGAGAGCACA


TACTTGCCTCCTAACTCATAAGGAATCTGTTGAATACTGCCATCCCTGTGACTAGCCGCAGACGTTGATAGCTCAAGCACAGAGCTC


TGTGCATGCAGGCTCAGGCTAAGTAGTCTTAAACCAAGGGAGGCCTTTGCATCACGTGTCCCAGAAGAGAATTATATTCTCCAAGTG


TTCTGGTGTGTGTGTGTGTGTGTGTGTGTGTGTATACTTGATACCATGTTTGTGTGAGACGGCATATGCATGGGAAAGACGCTGTTA


GAACTCCATATGTGCGTGTGAGACACTGCACATACTGTGTGTGTGTGTGTGTGTTTAGAAAGCTAGTTCTGAGGCAGTTAGGCTGTC


TCAGCAGCCATATGCCTAGAGGGCCTCAGCATGGCTGGGTGAGTCTCCAGTCCCTTGTTACTTGGTCACTGTGCCTGTGGTCCCCAC


CCTCCATTTGCCTGCTTTCCCCCCATTTGTCTTCCCCAGCCCCATCAGCCCCTCCCCAGAAGGTGACATGTGTGAGCACGGGCTCCA


CCACGGTCCGGGTAAGTTGGGTTCCACCGCCGGCCGACAGCCGCAACGGCATTATCACCCAGTACTCCGTGGCCTATGAGGCACTGG


ACGGCGAAGACCGTAAGCGACATGTGGTGGATGGCATCAGCCGTGAGCATTCCAGCTGGGACCTGCTGGGCCTGGAGAAGTGGACGG


AGTACCGGGTGTGGGTGCGGGCACACACAGATGTGGGCCCTGGCCCTGAGAGCAGCCCGGTGCTGGTGCGCACCGATGAGGACGGTA


GGCTGCAGTGGGTAACATTGTTATGAGGAGGGGTGGGGATGAGAAGCATGCCACCTGAGGCTGTCTGCCAAGCACCCAAGATCCCTC


CACAGGACCTGACAGACTCATTTTCTAAATTTAGGCTTAATGGTCTAAACTCTGGGGCGATGTAGTTGGTGGGGTATCCCGTATCCA


CGTCCTGGCTTCTGAGCCGTCTCCAAGATAACTGAAGCTTTAAAACCGTACAGGGCTGTGGCAGAAGCAGCAGCCCCACCTAATATG


AGAGCCAGGATTGAGAAGATGAGTGCAAAAGACTCAAGTGGGCTTTGTCTGGATACTAATGAAATTTGTTACAGATGGTGTGAGCCT


AGGTAGTTGAAGGTGTGGTACCTCACTTCCAGCTGTTCCCCACATCTATGTTTCCCATGAATAAGTAGCCCTGCTAGAGGGACCCAT


AGGGATGGCCCTCGGCAGGCAAATCAGCCAGCCAAAGAAACAACATTGGAACCTTTCCCAAGGGGGCAGGTGCAGAGTCACGGCCCT


AAAGTTAGCTGTACGTGCCTAAGCCAGGCGCTGTTGCTCCATATCTGACTCTCTTCTCTGCCTGGCCCCTAGTGCCTAGCGGGCCAC


CACGGAAGGTAGAGGTTGAGCCTCTGAACTCCACTGCTGTGCATGTCTCCTGGAAGCTGCCCGTCCCCAACAAGCAGCACGGACAGA


TTCGTGGCTACCAGGTCACCTATGTGCGGTTGGAGAATGGTGAGCCCCGAGGCCAACCCATCATCCAGGATGTCATGCTGGCTGAGG


CTCAGGTATGTCATTGACGGTGCTAGGTGGCAGGGTAAACAGTGACCAGTGTGTCACAGTGACCCCCTAGAGCCCAGATTTGTCCCT


CCAATGCCTGCCCTCAGAGGTGGTTATGCCTTTTATGGTCATTGGAGCTGCCTTGGACTGTCTGGGCAGGAGTTATTGAGATCGGGA


GGTGAGGCTCATGTTCCAGAGACTTTGTTCTTCTGTTAGGATTGTTAAGCTGTGCTAACCTAGGTCCTGCTACCCCCTCCACCCAGG


TAGCAGTCTTAGTTGCCAGTGCTCACGGGGCTGCTCCCAAAGACCCCCAGGCTCCTTGCACAGCACACTGGCTTCATCCTTGTGGTT


TGCAGAAAGCACATTTGCTGTGGCTTTGAGCTGAACTGCTGTCCCAGGCAATACTGTTCTTAGCATCACCTGGACTGCACAGCCAGG


GGCAGACAAGACTTTTCTCCATCCTCCATGGCCTCAAGCCAGTGACTGAGGCAAAGCTCTGCAAATAATGACCTGAGTGTCACTCTG


CTCTTGACCTGAGTGTTTCTCTCCAGGGCTGGACCTGCCAGCCCTTTTCTGTTGGAAGCTTCTGTCTTCCTGGGGCATCTGCCCACA


GGCTTACAGTGAGGTCAGTATTCTGACCCCCACCTTGCTAGTCCATCAAGGAGCACCGAATACTGTGAGATTATATGTGTGGCCAGA


ATGAGCCAGCATGTAGGTGGCAGGGATTGGAGAGGAACCAAGTCTCTACCCTGGGAAAGGACTAATCAAGTATAGGAAAAACTGTGT


TGTCTGTCCTTGGTCTCCCTGTCTAGAACCAGGTCCTGATGATTCTTGGGCCAGCTTCAAGTCCCAACAGAAAGATCCTAGATTCCC


TCCCCAACCAAGTGGGAACCCCATATTCTGCAGGCTGTGCTGAGGGATGAACCCCCACACAGACAAACTGCTTTCATACCTTTGGCT


AAGCTCCACCCTCTGAGCCAAAATTCTTTTCTACCCAGAGGGTACCCTCTTTCTTCTCCCAACCTGTCTATGCTGAAGGACCCAAGG


GTGGGGGAGGTGGGTGTGTTCATCAGCCTGCATTCCTGGGGCAGGTTGAGGGCTCCTCACAAAGTCTCAGCAGACACACCCGCTCAG


AAACATCCAGAGAATGACTCCATCCAGCCCCTCCCATCCTAGGAGTCTGGCGCCACAGCTGCAGCCTCTGTGGTTTCAGGAAAGTCA


CTTCGAGTACTTTTGTGTGCTGGTCCCCAAGAGTTTGAAGGGGGTTGGGTAATAAGACCAGGGACATTGTCCCCATATTTGTGTTCT


TTACAAGGAATATGCCCAAGCAGGCTCCAGGGAGGCCACGGAAGACAAGGCCTGCCCTTGTAGCCTTCCACCCCCTGGGACTTTGTC


ATTCTGCTTTGGGCCAGTGGGAGACCAGATGGTGCACTTATCCAGCCTGGCCCCAGGGCCTAGGTATCCCCTGTGTGACTCTTTTCA


AGGACACCCCAGCCTGCCCTTATCCACCCAATAGAACCATCTGTGCAGCCCTGGGCCCCAGTAAGATCAGAAAGAAGCATGTGGTGT


GTATCCCCACCAGATGTGCATAGCCCAGCCTGCCTCCCCTGTGCTCCCTCTAGATGAGACTCGCCACCCTCCGCCCCCTTTTTGTCC


CTTCCTTTTGTCTTTTCTCTCACTGTAGGAGTTTAGTCTAGCTACTCTCCATCCCCTTTTCCTTCTCTCCTCTCCCTACTCCTCTTA


CAGCCTCTTCCTTTCCCACCTACCCCTCTGTCTTTTTCCTCTCACTACCTGACATAGGAGGGGCTACCTGCGATAGCTTCACACCAG


GGCTCCCCTCAAGTAAGGAATCCTAACTAGACCTGGTTCCAGCCCGCTCTGATAATTCCAGGACTCTATAGCCTCTCTATATTCTGT


CGCAAAGACTGTGACAGAACTGTCTCAAATAGCAGGAGCTCAGGCCACTCCAGCACCAGGCTAGTGGACAGGCCAGACCAGCTTATA


TGAGGGTGATCTGGCTAGAGGACTCCAAACAGGGCCTGTCCCTCACTAGCCAACTCCTAGTTTCAAGACCACAAGGCTTCACATTAG


AGTCCTCACTCCATATACCTGTTCACCCAGCATACCAGTGCACGCTGGCATTAGAATTTACCACTGCCAGCCAAGAAACTAGTTTTC


CTATTTTGACTCCAGGCACCTGTAGAATCGAAATCAGGGGTGTGGGGTCTCCTTGTGGCTTTGGGGTAATGCCCAGGCTCTGAGCTG


GCTACTTACCCTTTATTATCTCTCTGGCAAGCCTGACTCTTGGCCCACTCCAGCGGTAAGTCCAGCACTTGTGTTCTAGGACACTCA


GCTCAGGTGACTCTAATTTAGTGTCTCAGCTGAAAGCAGGATGCATGGATGGATGGATAAGTGGATGGATGGATAGGTAGGTAGAAA


GAGAGAGAGAGAGAGAGAGGTAGGTAGGTAGAAAGATAATATAGATAGACAGAGGAAGAGAGGGAGGTAGATAGATAGATAGATAGA


TAGATAGATAGATAGATAGATAGATAGGGGGAGCAAGCTGAACAACCATAGCAGGACATTGGGACTCTAAGCACATATCTTCCCTCT


GCCTAAGCTGTCAAGTCTATCTCTACATCTGACAGTCCACCATGTCTCCCTGCCCTCGACAGGCCTGGTGCACACAATTGGTGCTCA


ATGATGCAGGAACTTGTGTCTTTGAGTGGGCACTGGTCCTGGGCTATCACCTCAGTGGGTACTTCAGAGCTATCTATCAGTTCTCCA


TGGGCCAGGTCCTCTCCAGGCCAAATCCTTCACCATCCTGTCTCCCTTTTTCTCCTTCTCCCGCTGTCAGTGGAGACCAGAGGAGTC


CGAGGACTATGTAAGTAACAGGTGTGCAAGCACGGGCAAGACTGGGTCAGACTGGGCTCATGGGACACTCCCCCTCTCCCAGCCTGT


GTTGCCGAGATCCACAGGGCACCAGCCACATCCAGAGAAAATTGGCGTGTAGACATGAGCACCAGGCTGAGCAGTGATTGGCGTTTC


CTCTAATCCGTACTCCTCGCCTGTCGAGCAGCAATTTGAGGCCAATGTTCACAATCGACCAGGACCTGGCCCCTGCTCTGGCCAGAC


GGGGATGGAGTTAAATCCAATCCCGATCGTTAGGCCTTATTGATCCCTAGAGTGAAAAATCACCTGCTCAGGCCCAGGCTGGGAGAA


GCACTGGGAGCCAGGTCCAACACAGGCACTGCTGGAGCCCGAGCCCTGGGAGACCCTCCAGCTTGGCCCTGCAGAGGGTTGTTGGCA


TCTGCAGTTGGCCCCACCTGAGGCTTAGAGCTGGAGGGACACCAGGGCTGGTGCTGACAGCCCTATGCCTACTCCATGGTGGTACTC


TCCCCTCCTCCTCCTCTCTGTGTGGCGTGGCTTGGTCTCCTATGGTGTTTCTCCGCATGTCCGGAAACATTGCCTTTGCTGGATGGG


TGTGTGGGTAGGATCCGCCAAGGTAGAAGGAAGTGGAGTGGCCGACTTCTTGGGCATCGGTGGAAACAAGAGGGGAATGTGTTCCTG


GGTTTGGGGAATTCTGTGTCCTGTCTTTTTTTTCCCTCTTATGTGGTCTCAGGAGGCATTGGATATCCCAGTCACCGGAGTAGATAG


GGTCACTGTAACTTACAGTGTTGTAGGTTGGGCCCTCTCCTTTACCCGGCTCTTTTATAAGTGGCCTTGCACCAGCTAATTCCAGAG


GAATGGTGGCCTGTATGCATTTGCGTGCCAAGAGGCATGGAAGGTACCTGGTGCATGCAAGGCTCTGTCTGTGTGTAGAGACCTCAT


GAGGTGTCACTCACAGCACAATGGCATGAAAGTAACAGTGTGGTCCTTTGTTCTTCTCTGAAACAAAGAATGAGCTATCTGCCCCAG


GCCTGGGGTTTTGGGTTGGGTGGCATGCTCCTAGCCCACGTCCCACCTGGCTGTCCTGCCTCCAGCAAAGGAAGCAGAGGAAGGATT


TGTCCAGCTTCACCTCCCAGGACCCTGGTCCTGTGTACCTGGGGCACCCTAGGCTCCAGTCTTCAGGTGACTGGTAGTCTAACTTCT


TACGCAGTATGATGGGACCTGCCTTTCCCCTTCTTCAGGAGACCACCATCAGCGGCCTCACCCCCGAGACCACCTACTCCATCACCG


TCGCTGCCTACACCACTAAGGGGGATGGTGCCCGAAGCAAGCCCAAGGTGGTTACTACAACAGGGGCAGGTGAGTGAGGGGTTCATG


GACAAAGCTGGGTGGGCAGCAGGGAGGATGGCACCAGAGCCCAGTGCGTGCTGTTCAGTCCCAGGACGGCCCACCATGATGGTCAGC


ACCACGGCCATGCACACCGCGCTGCTGCAGTGGCACCCACCCAAGGAGCTGCCTGGAGAGCTGCTGGGCTACCGTCTCCAATACCGG


CGGGCCGACGAGGCGCGGCCCAACACCATAGACTTTGGCAAGGATGACCAACATTTTACAGTCACCGGCCTGCACAAAGGGGCCACC


TACGTCTTCCGGCTCGCTGCCAAGAACCGGGCTGGCCCAGGAGAAGAGTTTGAGAAAGAGATCACCACCCCCGAGGATGTGCCCAGT


GGCTTTCCTCAAAATCTTCGAGTGACAGGACTGACCACATCTACCACGGAACTGACCTGGGACCCGCCGGTGCTGGCGGAGAGGAAT


GGTCACATCACCAACTATACTGTGGTCTACCGTGACATCAACAGCCAGCTTGAACTACAGAATGTCACCAACGACACACACCTTACA


CTCTTGGGCCTTAAACCGGACACCACTTATGACATCAAGGTCCGTCCACATACCAGCAAAGGCGCCGGCCCTCTCAGCCCCAGCATC


CAGTCCCGGACCATGCCCGTGGAGCAAGGTGTGTGCTGTGATCATGGCATTGGCTGCCCAAGCGTGACTGCTCCTAGGGACCTGTGC


TGTCCTTGACCCACTGACCTCTCGCAGCTGATCCACCAGCTTCTGCTGTGTGACACTTCACGCTCTCATGACCACTAACCTCTAATG


GACAGGCACCACATCCTTGGGTGTGTGGCCCTGACCTCTGCTGTCCTTGACCTACTGACCTATCTGCGTGGCCTTCCAATCTCTTGT


GATCTTGATCCACTGATCTCTTTCTGCTACATCACCTTCTAGGGTGTGCAGCTCTCTCTACTTTGCTCTGTAGCACTAACCTTTTGG


GGCCTAACCTACTGACATCCAGAGTCCGTGTGGCCACGTACATCTTGTGACCACAACCCACTAATCCCTGGCTACTCTGAACCAGTG


TCTGAGCCGAGCTTCCACCCATGCTCTTTCAGAGGTGTGGCCCCAGGCACAGTGGCATCCCCAGCCGGTTCAGTGTTCACTGTGGAA


GAACCTGGGTTAGGAGTTGGACTGTGCCATGTTAAGCTGCCTGGGGTACTTGGTTGTCACCCTTAGTCCATAGCCCCTCCCTCCCCT


ACTCCTGTGCTACAGCCATTGTCACATCCTCGGGCCCCTTCACCACAGCCCAGCTAGCCACAGATCTCACTCCCTCCTCGTGCTTCC


ACAGTGTTTGCCAAGAATTTCCGTGTGGCCGCTGCGATGAAGACATCTGTGCTGCTCAGTTGGGAGGTCCCCGACTCTTATAAGTCA


GCTGTGCCCTTCAAGGTGGGTAGGACTTCTGCCAACCTAGACCAGAGCTGCCTCCCATGTCTGCTCTGCATCGCCATTCCGATCCCA


GCTGCTCTTCCCCCTCCCCCTCCAGATCCTGTACAATGGGCAGAGCGTGGAGGTGGATGGGCACTCGATGCGGAAGCTGATTGCAGA


CCTGCAACCCAACACGGAGTACTCCTTCGTCCTGATGAATCGTGGCAGTAGCGCCGGGGGCCTACAGCACCTGGTGTCCATCCGCAC


TGCCCCGGACCTCCTACCCCAGAAGCCACTGCCTGCCTCCGCCTTTATAGAGGATGGCCGCTTCTCCCTCTCCATGCCTCAAGTGCA


GGACCCCTCGCTAGTCAGGTGTACAGAGGAGGCTGGAGGCTGGTGCAGATCGGGAGCGTAGCAAAGATCGATGAAGGTTCTGATGGT


TGCTCTGTCCACACAGGTGGTTCTACATTGTGGTGGTGCCCATTGACCGTGTGGGCGGGAACTTGCTGGCACCAAGATGGAACACAC


CAGAGGAGTTGGAGCTGGACGAGGTGCCTAGGGGAAGATCAGTACTGAGGGCAGCCACGTGGTGGGCAGTGGCCATCTTTCCCTGAG


TGTTGCCCCAGGAGTCCAAATCTGGCTGTCAGCCGCTCTCTCTCTCTCTGGGGAGAGGACCTCTGAGGAGTATCCCCAGGAGAATTT


TTAAAACTCCGGAAGGGCCTACAGGGACTTCCCTGGAGGTATTTGGTAAGAATCCCATGGTATAGGAGTCACTAGAGACATTTCTGC


AGCTCTCAGTGTGGACCTCAGAGATGCCTGTGGTGTAGAGCTTTAAGCCTAAGTTCTCCTGAACAGATGAAATCACCTCTTTCCTCC


TCACAGCTCATGTCAAAACTGCTTTCTCTGATTAGGATAAGGTTATTCATGTGGCCCTTCCTTATAGGCTACAAGGAGGGTCTCGCT


GTGATGTCAGAAGTATCCTGTAATGGCTATGGCCAGGCCAGGCCCATGAGGGTCCCCAGGAAGAGGGAACCTCTATATCTGCCTCAG


TAGCTAATGCCCCAGGGGAGGAGGCTCCCAGGCCTTGTGTGACTCTGTGCTCTCCTCTGCCAGCTTCTGGAGGCCATCGAGCAGGGC


GAGGAGAAACAGCGGAGGCGCCGGCGCCAAGCAGAGCGGCTGAAGCCTTATGTGGCGGCCCAAGTGGATGCGCTCCCTGACACCTTC


ACCCTGGGGGACAAGAAGAGCTACCGCGGCTTCTACAACCGGCCCCTGTCTCCGGATCTGAGTTACCAGTGCTTCGTTCTCGCCTCC


CTCAAGGAACCCATGGACCAGGTTGGCCTGAGCTGGCATGACTTTCAGAACCCCAAGACCCCAGGCTTAATCTAAGACCAGGCCAGC


TTCAGACCTTAGGAGACCCCGGGTCTGCATTATCCTGAGACTCCAGCATCCTAGGACTAGGACACCCCTGAGGACCTATACTGGATA


TCCCATGACACTAGGCCTCAGGGTGTGAAGATCAGACCTAACATGGCTTCAGTAACCCTGCTGACCTGTCACATGTCGGTCTCACTG


GTCTCGGTGCCCTCCCTGGGTTTGATGGATGAGGGTGGGGCTTTCTTGCTGTGCTGTGCTCATAGCCTTTGCTGTTGCTTCCTTCCC


TGGACCCCAGAAGCGCTACGCCTCCAGCCCCTACTCGGACGAGATTGTAGTCCAGGTGACGCCAGCACAGCAGCAGGAGGAGCCCGA


GATGCTGTGGGTGACAGGCCCTGTCCTGGCCGTCATTCTCATCATACTCATTGTCATCGCCATCCTCCTGTTCAAGAGGTGAGTGCC


GCGCCTGGTTCTGGGGGACAGAACCTGCCTCCTGCCTCGCTGGTACCCTCTGGTGCAGTGTTAAGTGCCCAGATGGACGGAAACAGC


GGGTCTGTGTGTGTGTGTGCACTCGGCTGTGCAGGTCCGCCTTTATGAAGAAGGGCTGAGGTGAACTGTGCGTGTCCCGAGGCGTGT


CTGTCTGTGTCTATATGTGTGAGTCTGTCATCTTCAGTTTGAAGGAGCCACAGCTTCCTGGTGTCCTGCTGTAAGCACTTTTCTTCT


GCCACCGAGTGACAGGCTCTGTAACGGCTATCACCAGCCCAGGCCCTCCTCTCCTCCTTAGGCCCACAAGAGGTCCAGGCTGAGTTG


CAGACCTACATCCCCATGAGAATTACACAACAGACATTTACTAAAGACCCATCATAGACGTGGCTGTCAACACTTACCTGTCTTGGG


TAGTTGTCGCACCTGTCCTTGGAGGTGCCCTGCTATCCTGTCAGCTTCCAAGCTGCTTCCAATTATTTTACTTGGTCTTGGTCATTC


CCAATATATATATATTTTTTTCCTCCTAATATTTTTAAGATGAGGTCTCACTGTATAGCCTTGGCTTCCCTACCGTGTAGTCCAGGG


TGGCTTCAGACTCAGAGACCTGCCTGCTTCTGTCTCCCAGGCTACTCTAGAAACTGAGGTAGAAGGATCCAGGCCTAACTTATCTAA


GGCCTCGAACTTAGGAATCTGCCTGCCTCTGCCTCCCAAGTGCTGGGATTAAAGGCATGTGCCACCACTGCCCAGCTTGTTTTGTTT


TTTAAGGTGAGGTTCTTTGGCTCGGTGTGGAGTGCCTGCCTTTGCGTGTACAAAGTTCTGGATCCAATCGCCAGTAGCACAAAAACT


TAAAAAGTTTTTTTAAAAAGCCTAACCTTTGAGCCTGACAGTTGAAATGCCTGGTTAAATGTGTCTTTAGCATTTCCCTTGACATCA


TTACACCAAATAAATACGGTCCCTTGGCCCCTGGCTCCTGCTCTGCAGCAGTGCCCCCCCCACACACACACACACACACAGCCCCAG


TGCCCCCTCACCTGGCAGCTGTTCATACCATGTTCTTACTTCTAGTCTCTGGTGCTTCAGAGACCCCTGGCTCCTGGTCCCATCTTT


ATACAGCCCCTCATCTACCCCAGAGTGCCCCACTGGATATGTGCTGAGCCCCCAGCAGCTAGCACATGGCTAGCTGTTGAACATGTC


CTGTGCTATGTGTGATGTGTCACCTCATGGAGGTACCCACTTCCCTGTCGTTATCCTGCCCTCATCTGGACCCCATAATCCATCCTG


GCAAGTTCCCTCCTTCCTCTTGCGGTCACAGACCTATAGGTGTCACTAAACAGTGTCCCTCCACCCACTTACCCTCACCATCCCCAC


TCAGGTTCTGATGTGTGTACATGGAGGTGAACTCCCTGAGGTTGTCCTATGGGTACCTTATAAGAGTCCCATGGTTCCCTTGTCATG


TGAGGGCTGAGTGCTTAGCAGCAACAATGACCATTCCTTTCTTCTGTCCTTGCCTGTCTCTCGGGACCTAGTAAACAAGAAAGGTAG


GAGTCGTTCCTTCTCTCTGTACACGCCTCCCCCTCTACTTATCCCTGTGCACATCTTGGGCCTGCAGGAAGGGGTGGAGCTCTGACC


AAACCCTCTTAGCCTGTGGCTTTAATCAGCAACCTGCCTGCTCAGCACAGGAGGCTTCTCCAGTTCTGGATGGATCCTCATGGGCAC


GAGGGGGCAGTCTCGATCACATTCAATGTCAGTCCAACTCTGTCCCTTCCGCAGAAGATGCTCCCCACTGGAGCTGTGCACGCTGCA


GCCCCCATTGCTTCCCTGAGTCCACAGAGCTCTCCAGAACCCTCCTTAGGTTCCCATTTCTCCATCCTAATTCCTACGAGAGGCCAC


CTCTGCACTCGGCAGAGCAGCAAGGAAAGGTGTCGTGATGCAGACACGTGCGGGCATATTTCCAAGTTCTCCCCGGACACTCCTGTG


CAGGGGCTGCACGTGGTCCCCAGTAGTCTGTCTGACCCTGTCCTTTTTAGATGGGCAAGGTGACACCAGTGAGAGAGGACTCTGTCT


GGCTAGGGCCCTGCTGTTCCTGCCCCTCCCCTGCTACTCTGGACATTGGCCCTGAGAGCCAGGCAGCTGGGACCCAGGCCCTCGTGA


TGGCGTTTGTGTGTTCTGTGTACCAGTGCATGTTTTCTCGTGGTGGTTTCTGCTGCATCAGCTGGGGTCGAGTTAAGGACAGCAGCC


ACTGCCCAGCGGTGACCTGCCTCCTGTCCAGAGGAACCACCAGCCTCTCTGGCCTCCCTCCCTCGCTGCACTGCTCCTGGGCCCACT


CCACACCTGCCGTCTCCCTGCCCTGTCCCTACCCTGTGTTCTCTCATGTTGACGCTGCTCTCCCCCTGGCTCACACCCAGAGATCCC


AGGATAAGGTGGGGTGGTGGGAAGACATCTGGGGCCGTGGGAGCTGCCTCTGTTCCCAGTTTTCACTAGCCTCTTCTTGTTTCTTTA


GGAAGAGAACACACTCCCCATCATCAAAGGATGAGCAGTCAATCGGGCTGAAGGACTCCCTGTTGGCCCACTCTTCTGACCCTGTGG


AGATGCGAAGGCTTAACTACCAGACCCCAGGTAGGGTTGATCCCTCGGCCTCTTGGCCTCCAGCTCAGTCCCACAGGTTGTCAAAAG


ACCTTAGTGCACGCTCACTTCTGGCTGCTTCTCTTCCTTTTTTGTTCCGTTTGAATTGACATGATGGGACTTCATGATGGATGGGGG


CATCCATATTGAACAGGTGGACAGGCTAGGAGACTTCTAGAGACAACAGAGGTCCCTGTGTGTCTCCAGTCTCTGAATAGATGGACT


GTAAGAGACCTCTTGAAGCCCTCAGCTCTGGCACAAGTGGTCAGTCTCAATATCTGCCCTCTGGCCCTTAACAACAAACACACACAC


ACACACACACCAGGCTGTGTTAGAAGTGAGAAGCTGTAGCAGACAGAATGGTAGGTGAGGGGCTCATACCTGGCCCTTGATGAAGGC


TATTTCAGGTTCACTGTGCAAGGGTGTAGGGTTCCTGCTCCAGGCTCAATACCTGTCCCTTCCCCTGAGCTGCTCTCATGTGACTTC


GAACTGTTCCTTCCACCTGGAATATCACTCCTTCCCTACACCCCAGAGGTGTCTCTCAGAGAGCGACAGTCTCTAGCTGTAGCTCCA


GGACCTGGCTGGCTCAACCCGTCCTTGTGTTTATCGTGTGGTACATTCTCGCTGGATGCTTGAGCACACAACAAAGGAATGAGTGAA


TGAAGTCATGTGTGCACACTGAGGGCTTATGTTTGTGTGAGCTGGTTATCACTGCGCATCAAATTACCCCTAACCTTCAAGGCTTAA


AACAACAGTAATTATGTCTTCTCTCTCACAGTTGTTATGAGTCAGGAATTGGGACAGGGCACGGTAGGATACCCAGCCAGGGTAGGC


CTTCAGCCGGAAGATTTGAAAGCTGGGAACTAGAATCTTATAAAGTGGGGCTGGCAAATTATGGCCTGGAGCCAAATACAGCTCACT


GTCTGCTTTATAAATAAAATTTGCCCAGCACACCACCACACCCATTCATTTCTGGGGACATTTGCACTACAAAGGTCAGTTGACAAC


TAGAAGGTGGAAGAGAACCCTGGGTGTCTGCAAGCCTTTAGCACTGGTTTTCTGGCCTTTGGTAGTGAACTTTGCCAACCCTAGGGT


GGTTTGTTCCGGTGGGAGGTAGTTGGCAGACGAGCTAGCCTCTTTGTGTAGCCTGGACTTCCTTATAGCATGGCGACTGAGTTCCAA


AGACACGTGTCTTGAGAAAGTGTTCCGTGTGGACCCAGCGGGCTGTTGTAACCAGTGCGTGAATCTGTGGTTAGAGGAGGCTGCTCT


CAGAGGGTGCCTCACTTTGTGGGCACCAGACAGAAAGTTGGGTTGGAGGTGGTTCTAAGTGGAAGCACAGTGTGTATACATCAAGTT


AAACCCCTGAAGGGTATTTCTGCAGCATTGGAGCCAAGAAGTGACCGTGACCGGCAGGCTGAGCAGCTTAGACTTCATCCTGACTGA


CCAAGGGAGTCATTGAAGGTCTTCATCAGAGGAGCAGCAGAGCTGGCTGCTTCTGTGGAGAGCGGGCGGGCCCTGGGGAAGACATCA


GGCAGTTAAGTGGTAGGAAAGGGAGGCAGGAGAAGAACAGAGTCTGGGAAGCTGAAGGTGGTAAGGCAGGTGAGCTGAGCTCACACA


AGGATGCAAAGCCAGTTCTGTGTCTGCTGCCATAGAGGATATCCAAGTGGCAGTAGGCCTTTGTGTCTGGACTTTGTGCTGACCTCA


GCCCGGGAGCCACCAGTGTGAATGGTACCAAGGATCAGGTAGTGGTCAAAGCTCAGAATGGGCAGACTCTCCCGGGACGAGCAGGAA


GGGAGAAGGGAACAGGCCGCAGGATGGTGGTGTTATAGGGGAGCATGCAGGCAGAGGTGTGGGCAGAAAGGTTCCCTGTCTCAGGTG


CTGGCGTAGTGTGGCACTGAGAGGGTAGGGCCCATAGCTGTGTTGAGGTATAGGACCCAAGCCTTCAGGCAGAAGTATTTCCATGGG


TTGAAAAGCAGCAAAAGGGAATGCAGAACGCTTTTCCATATCAGTGTGTGAAGGATGTCATGGGCACATGACATCCCTGAGAAGGGA


GGAACTTGAGATTTTAAAAGATTTTTCATTTCCGGTATGGAGACCATCTGAAAATGGCCAAGGTCAGATTTTGAGGGGGTGAGGGCT


GGGCTGGAGTGACTTTATTATAGGGTCTCAAGAGGCCACTCACACCTATGTTGCTTGGAAGCTCTCTCTTTGGGGGAGGGGGACTGT


CTGTTACTGGAAGGCACGTGAGCTGACCCACTCTTTCTGTCTGTGCCCCTTCCTCTTGCCCTTCACCTACAGTCCCTTCAGTGTCGA


ACCGCAGAACCAGGTGACCAGAAAGAGGGTTCCTGAGCTCTGCTCCTGTCCCATTGTTTTCTTTTGGTTTGTTTTCTCTGCAGGTTC


CAGTGCCCCCAGTTGCCCGAATATCTCAAGTTAGTTTTCAAAGTTCCCACATTGGTTTGGGGACACTTTGGCTTCAGTGTGTCTCCA


CTCTTCTACTTCCTCACGTCTCCCCACTTTCTCCTTGCCCTTTTCCCCTTGCCTTTATCCCTTCCCTCCCCTTCCCGCGTCTCCCTT


CTCTCTGTCCCCTCCTGTGCTCACTGGCTTCCTCCTGTATCTGCTCTCCCACCCTCTCTCCTTGTCCCTGCCGCCTCTGGTCTCCAT


CCAACCCCTCTGTGTGCCTCCGTCCTGATCCCTTGCCTGTCTTTGTATCTTCCTCCCCATCTCTGCTTCTCTCTCTCCCTACTTCTA


TGCCACTCTGCCATTGTCTTTGCGCTCCATGACCATTCCACCCACACACTTGGTGCCCGGGGTGACAGGGTCACCAAATCTCTGAGG


TGACTGGCGTCAATGAGGGGTCGGGGTAAGGGGGTGTCTGTCTCAGACAGGTGTGGTAAGAGCCCAGCTTCCACCCTCTTCCTGAGC


TCGAAGCCCCGTCTTAGTGGGAAGAAGCCCCTTGCTCCTCTTAGGCAGGCCTGGCAGGCAGAGAGCCCTGTTGTCCCGTGCAGCACC


AGGTCATCTGGACATGCTTCTGTGTGCTCACAGTACACACACCTCCATCTCTGGCCTCCCCTGATGCCCAGCCACTGTGTGTTCTCC


ATTCCTGTTGCCGCCGCCGCATGTGCTGTTGTCTCCATGCCACCAGTGCTGAGTACTTCATGATCACACATGTTCACACATGCCTTG


GGCTGTCTCTACCACCCTGACCAGAACTCACACTAATGCCACCCATGTGTCTGCCCCACCTCCCCCAGGTATGCGAGACCACCCGCC


CATCCCCATCACTGACCTGGCAGACAATATTGAGCGCCTCAAAGCCAACGATGGGCTCAAGTTCTCCCAGGAGTATGAGGTGAGACA


CCCACCACTCCCACCGTGTGTCCTCAGTCTCTCCAAGTCTGGTTTTGTTTTGTCCTGGGTCCCACCTGAGGTCGAGGATATTGGGAT


GTAGGCCAGGGAGATCAAAAGTTCAGTTGGGGAACTGGCCGTCATAGGTGTTGGGCTCAGCCCACAGGCTCACCATAGCCCTCTGGT


GGTCACCCTAGGACATGCTTCAGAAGGCTCTGCTAGGTGATGCCTGCAGAAGCAGACACTGATTTAGTAGCAATGGCTATAATATCT


AATCTCCAACAAGAACAGGCCTGCACTTACCAGGTACGGGACAGCATCCTCTTACTCGGTCCCCCGTGGAGTGGTACTGTCACAGTC


TTGTCTTACATACCAGAAACCAGACTCAAACAGAGGTGTGAGTTACCTAGAGTCAAACAGCTGAGGAGTCGTGGAGCCACCCAGACC


TTGCCTGTGCTGGTTTCATGACCATCCGCACTTCAGTCTTGCATAACAATGTTACTGAGTCTCCACATGGTAACCATTGTCCGAGAA


GGGTGGGAGGGTCTGTTCTCAGCCCCGCTTCCATTCCCGCTCCCACATGTGATCACACATGCATGCCGAAACACATAGCTCATAGAT


GGGGAGTCAGGAAGCCCTCCAAGTGTTCGCCTCACTCTGGCCTTCACCTCTGTTTGCTAGCTCAGACTTCAGGGTCAGTGACCACCT


GGTTCACCCACAGCTCTTTGTCAGGGACCTTTGGGTGTTCCCAGGCCATACAGTCAGGGGAGCCTTGTTAGAAAGGAAGTGCTAAGG


AGACCCCCTTTCTTTGTCTCCCTGCTGTACTGGCCGCTCTTTTGTCAGCACTTGGCATACACCTCAGAGGATGACTGATGGACAGAT


GATGGATAGATCTGTTCAGCTGGACCCAGGGGGTTGCTCTCTTTTAGTCAGGTGTCCACTCTTGAGTTATGTTTGGGGGATATATCC


CTGGGTACCGGATTTGCCCTTCCGAGGGCACTGGGCCAGGTAGATCCTAAAGGCGACAGGCCAGGCTTCCAAAGAAGAAAACTGAGC


TTGGCAGGTAGACAGATGAGCATGCCTCTGCACAGCAACAGTGTCACCTCTGCTGTGGAGGCAGAGCCTGTCAGCCGGGTGGCCTGG


ATTTAGCTTAACTTCTGGACAAGGAGGCCTTCCTTGTTTTTTACCAGTATTCGCCCTTGTCCTGCCCCACGCCTTGGCATCCTTCCT


ATAAGCCCCTGCTCACGGCCGTCACCTTACCACCTCCCCTCCATCCCTCCCATCTGAGCGTTCTTTAAAGGCCCTTCTTTGTCCTAG


AAGCCACCAGATCTATTGTGGGCTTTCCCGAAACTTTCTCTTCATGGTCTGTAGGTCATTTGTCAGACTGTTGTTAGCACTTAACTG


TATTCCAGTCCCTATGCTGACATGTAGAAGCAGATGGCCTTGGGACGCAGTCACTGAGAAACACAGACAGAGCAGTAATCGTTGCTG


TGAGTGTGTGGTTCTGACAGCATGCACTAAAATCATATATAGCAAACACAATGGTGGGTGTGTCTGGTGGGTGGGGCCTCACAGAAG


TGATGAGACAGCCTCCTTAGAGAATAAGGTGGCTGGGACCAAAACGGAGGAGACTGTGATACAGGCATCGATTCTTTCCATCCTCAA


AGGAAGGACAATAACTCAAACCTCTCTTGAGTAAAAAGATGGAGAAATGCACGCAGTGGCTTAGGACCGTGCTGGGCACACCGTGAG


CTCACACAGAAATGTAGCTGTTAGCATTTTTGTGTCCTGAGCCAGTCAAGAGCATGGGAGGCCTCTGAGCAGGAATTTGATACTCAG


ATCTGCATTTTTTTTTTTTTTGAAAGACTGTTCTTGCTGAAGGACAGAGAGGGTTGGAGCAGGGCAAGAGAAGAGGCCTGGAGGTAC


CAAGCAGAGCTAGCTGCTGGCAGCAGCAGCAGGTTGAGAAAGGCAGAGGAAAGGAGTGTACGGGGGTGTGGTAAGCAATGGGAGGGA


CCTTGGGGAGGTCCCAAGATGGACTTTAAACCTGGCTGGGCTTCCTGGGTCAGTGATTTGTGCTATCCACTGAGGGGTGGGGGGGTC


ACATCAGAACCTGCTTTGACAGGAAACAGATGAGCTGGCCTTTAAAGGGACTGGGGTGGAAAGAGCTGTGAAGCTTGCACATGGAGA


TGTCTAGGGGGCCGCAGGATAGTAGGGGCAGCTCTGAGATGTAAGCAGGAGAGTCCTGTGAATGGGGTGGCGGTGGCTAATGGGAGT


GGTTCAGTCAGTGAAGATTGACTTACAAAAGGTGAAGATTGCAGCTATAGCTGTGTAAAATGGCCACTTGTAATCCAGAGTGGGGAG


ACAGAGACAGAAGCCACCATGGTACTACTGGCTAGCCAGCCTGGCTTACTTGGTGAACCGGGGGCCACTGAGAAGTCCTGGCTCAAA


GGCAGAGGGTGTTGCTAGGGTTGTCTACCACACAAGTGCACAAACACATATGTGTACACACATGCATTTTAAGAGAGAGAGAGAAAA


GAAAAACAAATCTTGTGAATGGGCTATGGATGAGACTAATTTGGTAGAGTGCTTGCCTAGAATTTGCAAAGCCCTGGATTTCCTCCA


GCATCACATAAATGGGGTAGCACACACTTTAATCCCACCACTCACCCACACATAACATGGAAGTAGGAAGATGAGAGAGAACTTTGG


AGCCATCCTTAATTGTATCCTATATAGTAGGTAGTAAATTCAAACCTAGCCAGGTATACATGAGACCCTATCCAAACAAGCAAACAA


ACAAAACATTTCCTGAGCAACGAAGTGAGAAGAGAGCCAGGGAAGAGATGTAGAGGAGCTTAGATCCTGCCTACGGGGAGGGCAGGG


AACAGACAGAATAGGAAAAGCCAGAGATGGAGAAGAGAGCTGGGCAGCATGGTATGTGGACCTGTAGCCTTGGACAGTCAGTCTCCA


GCACAGCCCAGGTGGCCGCATCATCATCATCATCATCATTATCTCCATCTCATTCCACTGGTTGGATGCAGGGCCTGACCCATGACC


CACCTGGTCTTCATAAGCTCTACAAGGGGCTGCCATGGAAGTTTGAGTCTTCAATTTATCTCTTTCCAGACTTGGGCTGGGGAATGT


AGGTGTTACTTGGCTGCAAAGCACCATGGATAGGCCTCCCACGACTTGGCCCTCACTTTCCCTGTTTCTTCCATTTCTGGCAGTCCA


TTGACCCTGGACAGCAGTTCACATGGGAGAATTCCAACTCGGAGGTGAACAAGCCCAAGAACCGCTATGCAAATGTCATTGCCTATG


ACCATTCTCGAGTCCTCCTCACCTCCATTGATGGTGAGCCCGGGGCACAGTGCCCCCTTGCCCTTTGCTGTCCTGTACCCTGCTCTC


CAGAATGCTCTGAGCCCCAGGTTAACACTCTCGAATCCCTTTGCATTCCTGTAGGTCTTCCTGGGAGTGACTACATCAATGCCAACT


ACATTGATGGCTACCGAAAGCAGAATGCCTACATCGCCACACAGGGTCCGCTGCCCGAGACCATGGGCGATTTCTGGAGGATGGTGT


GGGAACAGCGCACAGCCACAGTGGTCATGATGACCAGGCTAGAGGAGAAATCCCGGGTGAGGGGGGTGATGCTGGGTACCACCTCCT


GTGAGTCTTTTCAAGGCACTCCCCAAAGGCTGTGGTTTTCCTGGAGTATTGTCTCATCCCCTAGATAGAGGGGAACTGCTGGGATGT


AATGTAATGTGGTCCCCAGGTGTTTATGGGTTCCCGGGATGTTAATATGTTTTACCAAATGCTGTCGTTTTCTGGAATGTTAATATG


TTCCCCAGTTTCTGGGGTGTTCCTGGGGTATTCACATGTTCCCCAGATGCCAGAGTGCTCCTGGGGTGTTCACACATCTAAGTTAAT


TAGTGGAAGGAGCTGCTGATGTCTGCTTTTGCACCGCGAAGCATTGACTGGAACATAAAATTTACAGAGCTTGAAAATGGGGCATAA


ACGTTATGGGTAAATTTGGCAGAAAATGTGCCTGGTACGATCTGGTGTTGAATAAATAATTTTCAATTATGGTCCTCCTTCAGCCAG


TGAGGGCCAGGGTGGTAGCTTAGTGTGAGGAGGTTTGGAGAGGAAGAGGGAAGTGAGAATCGAGGGAGCTGGGGCCTTCCCCTTGCG


TCTGCCTGTTTGAGCCTTTGGGCATCCTATAACTTTGTCCCCTGTCCTGCCCATCCCCCTCCAGGTGAAGTGTGATCAGTATTGGCC


AGTCCGTGGCACTGAGACCTATGGCCTCATTCAGGTGACCCTGGTGGACACTGTGGAGTTGGCCACATACACCATGCGCACCTTTGC


CCTCCATAAGGTATGTCCCTGAGTTCCCAAGCACTGGCCCATCCCTTAGGTTGTAGCCTGAGTGTGATGGGCTGGCGGAGGGCAGCT


GTGGGGTCAGGGCCTGGGAGGTGTATGAGGGGTTCTCACGGCTTGTGTTAGGTGACTGTCTGCTGTGGCTTCTGAGTGTCACCTGAG


AGTGGCTGGTCTGGCCCCTTCCCTGGGTGTGTGGCAAGCAAACCTCAAACCTCATCTCCGTTGACCTTTCCCAGAGTGGCTCCAGTG


AGAAGCGTGAGCTGCGTCAGTTCCAGTTCATGGCCTGGCCAGACCACGGCGTTCCTGAGTACCCCACTCCCATCTTGGCCTTCCTGA


GACGGGTCAAGCCCTGTAACCCACTAGATGCGGGGCCCATGGTGGTGCATTGCAGGTGAGAGTCCAGAGCCACCAGAGGGGAGGGGT


GGGAGGTGAGGGGACCCCTGCCCCAAGCTCTGCTCTTCTCCTCAGTGCGGGTGTGGGGCGCACAGGCTGCTTCATCGTCATCGACGC


AATGCTGGAGCGTATGAAGCACGAGAAGACGGTTGACATCTATGGCCACGTGACGTGCATGCGCTCACAAAGGAACTACATGGTGCA


GACCGAGGACCAGTATGTGTTCATCCACGAGGCCCTGCTAGAGGCTGCCATGTGCGGACACACCGAGGTGCTCGCTCGGAACCTCTA


TGCCCACATCCAGAAGCTAGGCCAAGTGCCTCCCGGGGAGAGCGTCACGGCCATGGAACTTGAGTTCAAGGTGGGACTCCAGAGGCC


TGACTTGGTCGGTCGTGGGAAGCCTGTTTGCAGCAGGCCAGGCCTGACAGAACCCTTGCTCTTCACAGTTGCTGGCCAACTCCAAGG


CCCACACGTCGCGCTTTGTCAGTGCCAACCTGCCCTGCAACAAGTTCAAGAACCGCCTAGTGAACATCATGCCCTATGAGCTGACCC


GAGTGTGCTTGCAACCCATCCGTGGTGTGGAGGGCTCAGACTACATCAATGCCAGCTTTCTAGATGGCTACAGGTCGGCATGCTTCT


CCCTGCTGCCCCACTGTGCCCCTTCTGGTACCTTGGTCTGCTTCTGGTTGGGAGAGTTAAGAGCTAATCCAAAAGATCAGAGTGAGT


TGGGGACAGAAGTGAGGGCTTCCTGGAGGAGGGCTGCTCTCTGAGGAACTAGACAATGTCAGGATAGGTGCGGGCAGCAGCACCTCC


ATCATGTGAAGTCTTATGTCACCCAGACAGCAGAAGGCCTACATAGCTACACAGGGGCCTCTGGCAGAGAGCACCGAGGACTTCTGG


CGCATGTTATGGGAGCACAATTCCACCATCATCGTCATGCTGACCAAGCTTCGGGAGATGGGCAGGGTAAGCCCACCCCTTCTCCTG


GGGCCCCTCTCATACCAGGGGGGACACCAGCTACCCTTGGGAAAGGGGAACCTCCTCCACCCTCTGCTCTCATGCCCCAGCTCCCCA


TCAGCATGGCCTCAGACCTCTTTACCAACACCTGAGGCACCCCTTCCCAAAGTCCTCTGAAAGGTGGCATTCTCTTCTGGCCTCCCC


ACCTGATCTTGGGCGGTGCCTGGTGTTCTGTCCACAGGAGAAATGTCACCAGTACTGGCCAGCAGAGCGCTCCGCTCGCTATCAGTA


CTTCGTTGTTGACCCGATGGCTGAGTACAACATGCCCCAGTATATTCTGCGTGAATTCAAAGTCACAGACGCCCGGGTGAGTGTCAG


CCAAAGAATATGCACACAGATGTGTCCCTCGAGCTACCCGGGCACACGTGGCTCCATCTGCCCCAAGACACTGCAGGGATCTGAGTC


GTGGGCGAGTTGTTTGCGTTACCTCCTAGAGTGTCCTTGAGAGTGCGTCCCTGGGTGGTTGTGCTCCTGGTTTAGAGGGCCTAGTAC


CTAACATCCAAACCTTCATTGTGACCCCTGACCCTCTCTCCCAGGATGGGCAGTCAAGGACAATCCGACAGTTCCAGTTTACAGACT


GGCCAGAGCAAGGAGTACCCAAAACAGGTGAAGGCTTCATCGACTTCATCGGGCAGGTGCACAAGACAAAGGAGCAGTTTGGCCAGG


ATGGGCCCATCACGGTGCACTGCAGGTTGGGACGGCCCCCGTGGAGGGATATGGGAGGGGGGACGGTGGTCCCGAAGGCCAGGGAAG


TTGATTGTGTGAAGGGAGCAGGACTCCTGACACAGCCATTCTCTGAGCAGTGCTGGTGTGGGCCGCACCGGTGTGTTCATCACCCTG


AGCATTGTCCTGGAGCGCATGCGGTATGAGGGTGTGGTTGACATGTTCCAGACCGTGAAGACCCTCCGCACACAGCGCCCTGCAATG


GTGCAGACAGAGGTATGCAGGCCAGAGGGAGGGACCCACGTGTCTTTGCTACAACCCACAGCTGCACCTGCAGCTGGCCCACGTGTA


TTTGTTCTCCTTATAGCTCTGTGGTATTGCTTGTCCCACATGGCGTGCAGGGAAGAGGAGAGGGAGCTGTGTTCATTCCGTAGCCCC


TTCCTGAGCGCCAGTGTGTCATGTTGCCTTTGGGGTCAGAAGTAGACGTAGCAGTCTGTGTAAGACGGTGGGTGAGTCTGGGTACAG


ACAAGTGGTTTGAGTAGCAGAGGTGAACACAGGCCTGGGAGAGGCAAAAAGGAGAAATGGCCTTTCGAGACTTCAATTGGAGAGTAC


CTGGGTAGTTCTCGGTGTTCAGCATCTGCTCTTAGCCAACAGAGGCCATTTCTGTGGCCACTGGCTGCAGCACATGCAAACCCTTGT


GTTTGGAATAGCTATTGGCTCTGTTCACACTGACCAGTCCCCCTCTTTCCTCAAAGGACCAATACCAGCTGTGCTACCGTGCGGCCC


TGGAATACCTCGGCAGCTTTGATCACTATGCAACGTAACTACTGCTCCCCTCTCCTCCGACGCTCCCCCGCGGGGCTCCGGAGGGGA


CCCAGCTCCTCTGAGCCATACCAACCATCGTCCAGCCCTCCTGCACGGATGCTGTTGCCGGCAGAGCACAGCCCACTGGGATCACAG


CATTTCGGGGAACATTGCCACACCAGTCAGAGAGCCCAGAACACCTGGGCAAGTAGGCGGACTGGCAGCCTGGCTCTGGGCCCTCGT


CCACCGGGCCAAGTGGAGCCCCGCTTCAAGCTCTCTGTTCAGCTCCGCGTTCTCATGCTTCTCATGGGGTGGGAAAAGGGGGCAAAC


CCCCCACTTTTTATACACTAGGCGGGGTAGACTGCGGGGTCCTAGCCTCTTCCTCCGACTTTGCTTTTGCAGGTCTTTCACTGCAGA


TGGGGCTGCTGTGGGAGTTGGGACTTGTTTGTTTTCCTTTTTGAGTTCACGTTGGATCCTTTCTTGTACAACTTCTGCGGAAGGACA


CAGTAGTAACTCGCCTTCCTTGTGCAGAGCTAGGGCCCTACCTGAGCAAGTCGGCTGTGGCCCGGGAGGCAGCGTGACTCCTGCTGT


CCTCCAGCCTTTCAGATGAGATCCTATTCCAGCCAAATGCAGGGAAACACTTTATTTTGTTTGTTTTAGGTTTTGTTTTTCCTTGAG


AGCCTTTTTTTAGGCCCCACAGACAGTGGTGGCTGGGGAGGCGATAGGAAACACATTCCCCAGTGTGCATTTAACATTCATAGCCTA


CAACCACAGACGTGTCTGGGGGAGCCTGGCAAGGCGTTCCTCGTCACCATCGTGTTTGCAAAGGTTCAAAAAACAAAAATCAAAAAA


AAAAAAAAACATAAAAATATTTTTTTTTAAGAAAAGAAATAAAGATTCATCCCCTGGCCTCTACTTCAGATTCGAAGTGGGAGGCAA


CTCAATGTGCCTGGGGCTCGCCATGGGCCCACAGAGTCTCGCTATCATCCCCAGCGTCGCAGTGTGGCAGGTGTTTGTAGGCTGTGG


GTTCTGGCCACCTCGGGAAATGAATGGCACAGGTGAOGGCCTGTGCCACGCCCCACACACCTCAGGGCCAAGCGGGGGCGTGGCTGG


CCCTTCAGGTCAGGCCAGTGGGCCTGGTAGCACATGTCTGTCCTCAGCCGGACAGATGCTTTCTCTCCTGGTTTGCAGCTGTCTTCA


AATCCCCCCATGACCCCCTCTTCCCACTCCTTCAAGTTGCCCTCACAAACCAATGTGGCAAGACTACTGGACTTGTATCCATGGTAC


TATACTCAGTCCTCTTATCTCAGCTTGCTGAGGGGCAGGGAGAGGGTCTCTTCCTCTGGGCAGCACTATCTAGATAGGTAAGTGGGG


CCGGOGAAGGGTGCATAGCTGTTTTAGCCGAGGGACTCGATACCGACGTCCCCAGATATAGCTAGGCTAAGTCAAGATCAACAGTCC


GGGGTTGGTGGTGTTGGATGAAACATTCATTTTTACCTTGTGGATGCTAGTGCTGTAGAGTTCACTGTTGTACACAGTCTGTTTTCT


ATTTGTTAAGAAAAACTACAGCATCATTGCATACTTCTTGATGGTAATAAATTTGAATAATCAAGATTTCTTACACACTAGGCCTCT


GTCTCAGCTCCTGTATCTAGAGTGTGGTATCTTAAGTCTATGGCTGGGGTGGGTTCTGAGGAGTC





MOUSE MRNA SEQUENCE: mR28-021.1 (Seq ID No: 64)


AGGAAGGAGCGGAGGCCCTGGTGCCCTGCCCTCAGTGCTGACTGCCCAGCGAGAGTGACTGGTATAAGCAAGCAGAGACCCGGTGGA


TTGTCTTAGGCTGTGGCTGGCTGTGGAGCTAGAACCCTGGATGGCTCCCGAGCCAGCCCCAGGGAGGAGGATGGTGCCCCTTGTGCC


TGCTCTCGTGATGCTTGGTTTGATGGCAGGTGCTCATGGCGACAGCAAACCCGTCTTTGTTAAGGTCCCCGAOGACCAGACTGGGCT


CTCGGGAGGGGTGGCCTCCTTCGTGTGCCAAGCCACAGGGGAACCCAAGCCTCGAATCACGTGGATGAAGAAGGGGAAGAAAGTCAG


CTCCCAGCGCTTTGAGGTAATTGAGTTTGACGATGGAGCAGGGTCAGTGCTGCGGATCCAGCCATTACGAGTGCAGCGAGACGAAGC


CATCTATGAGTGCACAGCCACGAACAGTCTCGGGGAGATCAACACAAGTGCCAAGCTGTCAGTGCTTGAAGAGGACCAGCTGCCGTC


TGGGTTCCCGACTATCGACATGGGACCTCAGCTGAAGGTGGTGCAGAAGGGTCGCACTGCCACCATGCTGTGTGCAGCCGGTGGGAA


CCCAGACCCTGAGATCTCTTGGTTCAAAGACTTCCTTCCTGTGGACCCTGCTGCAAGCAACGGTCGTATCAAACAGCTGCGATCAGG


TGCATTGCAGATAGAGAGCAGCGAGGAGTCTGACCAAGGCAAGTACGAGTGTGTGGCCACCAACTCTGCAGGCACACGCTACTCGGC


CCCCGCCAACCTGTATGTGCGAGTGCGTCGCOTGGCTCCTCGTTTCTCCATCCCTCCCAGCAACCAAGAGGTGATGCCGGGCGGCAG


CGTGAATCTCACATGTGTGGCAGTGGGCGCGCCCATGCCGTATGTGAAATGGATGATGGGCGCCGAGGAACTGACCAAAGAGGATGA


GATGCCAGTTGGCCGAAATGTTCTGGAGCTCAGCAATGTCATGCGATCTGCCAACTATACCTGTGTGGCCATCTCTTCATTAGGCAT


GATAGAAGCCACGGCCCAGGTCACAGTAAAAGCTCTGCCAAAGCCTCCAATTGATCTTGTGGTGACAGAGACAACCGCCACCAGTGT


TACTCTGACATGGGACTCTGGAAATACCGAGCCTGTGTCCTTCTACGGCATCCAGTACCGCGCAGCTGGCACAGACGGCCCCTTCCA


GGAAGTGGATGGTGTGGCCAGCACCCGATACAGCATTGGTGGCCTCAGCCCCTTTTCGGAATATGCTTTCCGTGTGTTGGCTGTTAA


CAGCATTGGGCGAGGACCACCCAGTGAGGCAGTGCGAGCACGCACGGGGGAGCAGGCACCCTCCAGCCCTCCGCGCCGTGTGCAGGC


TCGAATGCTTAGCGCCAGCACCATGCTGGTCCAGTGGGAACCACCTGAAGAGCCCAATGGCCTGGTACGGGGATATCGCGTCTACTA


TACCCCAGATTCCCGACGCCCTTTGAGCGCCTGGCACAAGCATAACACTGACGCAGGACTCCTTACCACCGTGGGCAGCCTGCTACC


TGGCATCACCTACAGCCTCCGAGTCCTTGCCTTCACTGCTGTGGGTGACGGCCCACCCAGCCCCACCATCCAAGTCAAGACACAGCA


GGGAGTGCCTGCACAGCCTGCGGACTTCCAGGCTAACGCTGAGTCGGACACCAGGATCCAGCTCTCGTGGCTGCTGCCCCCGCAGGA


GCGGATCGTCAAGTATGAGCTGGTGTACTGGGCAGCCGAGGATGAGGGCCAGCAGCCCCATCAGCCCCTCCCCAGAAGGTGACATGT


GTGAGCACGGGCTCCACCACGGTCCGGGTAAGTTGGGTTCCACCGCCGGCCGACAGCCGCAACGGCATTATCACCCAGTACTCCGTG


GCCTATGAGGCAGTGGACGGCGAAGACCGTAAGCGACATGTGGTGGATGGCATCAGCCGTGAGCATTCCAGCTGGGACCTGCTGGGC


CTGGAGAAGTGGACGGAGTACCGGGTGTGGGTGCGGGCACACACAGATGTGGGCCCTGGCCCTGAGAGCAGCCCGGTGCTGGTGCGC


ACCGATGAGGACGTGCCTAGCGGGCCACCACGGAAGGTAGAGGTTGAGCCTCTGAACTCCACTGCTGTGCATGTCTCCTGGAAGCTG


CCCGTCCCCAACAAGCAGCACGGACAGATTCGTGGCTACCAGGTCACCTATGTGCGGTTGGAGAATGGTGAGCCCCGAGGCCAACCC


ATCATCCAGGATGTCATGCTGGCTGAGGCTCAGGAGACCACCATCAGCGGCCTCACCCCCGAGACCACCTACTCCATCACCGTCGCT


GCCTACACCACTAGGGGGATGGTGCCCGAAGCAAGCCCAAGGTGGTTACTACAACAGGGGCAGGACGGCCCACCAATGATGGTCAGC


ACCACGGCCATGCACACCGCGCTGCTGCAGTGGCACCCACCCAAGGAGCTGCCTGGAGAGCTGCTGGGCTACCGTCTCCAATACCGG


CGGGCCGACGAGGCGCGGCCCAACACCATAGACTTTGGCAAGGATGACCAACATTTTACAGTCACCGGCCTGCACAAAGGGGCCACC


TACGTCTTCCGGCTCGCTGCCAAGAACCGGGCTGGCCCAGGAGAAGAGTTTGAGAAAGAGATCACCACCCCCGAGGATGTGCCCAGT


GGCTTTCCTCAAAATCTTCGAGTGACAGGACTGACCACATCTACCACGGAACTGACCTGGGACCCGCCGGTGCTGGCGGAGAGGAAT


GGTCACATCACCAACTATACTGTGGTCTACCGTGACATCAACAGCCAGCTTGAACTACAGAATGTCACCAACGACACACACCTTACA


CTCTTGGGCCTTAAACCGGACACCACTTATGACATCAAGGTCCGTGCACATACCAGCAAAGGCGCCGGCCCTCTCAGCCCCAGCATC


CAGTCCCGGACCATGCCCGTGGAGCAAGTGTTTGCCAAGAATTTCCGTGTGGCCGCTGCGATGAAGACATCTGTGCTGCTCAGTTGG


GAGGTCCCCGACTCTTATAAGTCAGCTGTGCCCTTCAAGATCCTGTACAATGGGCAGAGCGTGGAGGTGGATGGGCACTCGATGCGG


AAGCTGATTGCAGACCTGCAACCCAACACGGAGTACTCCTTCGTCCTGATGAATCGTGGCAGTAGCGCCGGGGGCCTACAGCACCTG


GTGTCCATCCGCACTGCCCCGGACCTCCTACCCCAGAAGCCACTGCCTGCCTCCGCCTTTATAGAGGATGGCCGCTTCTCCCTCTCC


ATGCCTCAAGTGCAGGACCCCTCGCTAGTCAGGTGGTTCTACATTGTGGTGGTGCCCATTGACCGTGTGGGCGGGAACTTGCTGGCA


CCAAGATGGAACACACCAGAGGAGTTGGAGCTGGACGAGCTTCTGGAGGCCATCGAGCAGGGCGAGGAGAAACAGCGGAGGCGCCGG


CGCCAAGCAGAGCGGCTGAAGCCTTATGTGGCGGCCCAAGTGGATGCGCTCCCTGACACCTTCACCCTGGGGGACAAGAAGAGCTAC


CGCGGCTTCTACAACCGGCCCCTGTCTCCGGATCTGAGTTACCAGTGCTTCGTTCTCGCCTCCCTCAAGGAACCCATGGACCAGAAG


CGCTACGCCTCCAGCCCCTACTCGGACGAGATTGTAGTCCAGGTGACGCCAGCACAGCAGCAGGAGGAGCCCGAGATGCTGTGGGTG


ACAGGCCCTGTCCTGGCGGTCATTCTCATCATACTCATTGTCATCGCCATCCTCCTGTTCAAGAGGAAGAGAACACACTCCCCATCA


TCAAAGGATGAGCAGTCAATCGGGCTGAAGGACTCCCTGTTGGCCCACTCTTCTGACCCTGTGGAGATGCGAAGGCTTAACTACCAG


ACCCCAGGTATGCGAGACCACCCGCCCATCCCCATCACTGACCTGGCAGACAATATTGAGCGCCTCAAAGCCAACGATGGGCTCAAG


TTCTCCCAGGAGTATGAGTCCATTGACCCTGGACAGCAGTTCACATGGGAGAATTCCAACTCGGAGGTGAACAAGCCCAAGAACCGC


TATGCAAATGTCATTGCCTATGACCATTCTCGAGTCCTCCTCACCTCCATTGATGGTGTTCCTGGGAGTGACTACATCAATGCCAAC


TACATTGATGGCTACCGAAAGCAGAATGCCTACATCGCCACACAGGGTCCGCTGCCCGAGACCATGGGCGATTTCTGGAGGATGGTG


TGGGAACAGCGCACAGCCACAGTGGTCATGATGACCAGGCTAGAGGAGAAATCCCGGGTCAAGTGTGATCAGTATTGGCCAGTCCGT


GGCACTGAGACCTATGGCCTCATTCAGGTGACCCTGGTGGACACTGTGGAGTTGGCCACATACACCATGCGCACCTTTGCCCTCCAT


AAGAGTGGCTCCAGTGAGAAGCGTGAGCTGCGTCAGTTCCAGTTCATGGCCTGGCCAGACCACGGCGTTCCTGAGTACCCCACTCCC


ATCTTGGCCTTCCTGAGACGGGTCAAGGCCTGTAACCCACTAGATGCGGGGCCCATGGTGGTGCATTGCAGTGCGGGTGTGGGGCGC


ACAGGCTGCTTCATCGTCATCGACGCAATGCTGGAGCGTATGAAGCACGAGAAGACGGTTGACATCTATGGCCACGTGACGTGCATG


CGCTCACAAAGGAACTACATGGTGCAGACCGAGGACCAGTATGTGTTCATCCACGAGGCCCTGCTAGAGGCTGCCATGTGCGGACAC


ACCGAGGTGCTCGCTCGGAACCTCTATGCCCACATCCAGAAGCTAGGCCAAGTGCCTCCCGGGGAGAGCGTCACGGCCATGGAACTT


GAGTTCAAGTTGCTGGCCAACTCCAAGGCCCACACGTCGCGCTTTGTCAGTGCCAACCTGCCCTGCAACAAGTTCAAGAACCGCCTA


GTGAACATCATGCCCTATGAGCTGACCCGAGTGTGCTTGCAACCCATCCGTGGTGTGGAGGGCTCAGACTACATCAATGCCAGCTTT


CTAGATGGCTACAGACAGCAGAAGGCCTACATAGCTACACAGGGGCCTCTGGCAGAGAGCACCGAGGACTTCTGGCGCATGTTATGG


GAGCACAATTCCACCATCATCGTCATGCTGACCAAGCTTCGGGAGATGGGCAGGGAGAAATGTCACCAGTACTGGCCAGCAGAGCGC


TCCGCTCGCTATCAGTACTTCGTTGTTGACCCGATGGCTGAGTACAACATGCCCCAGTATATTCTGCGTGAATTCAAAGTCACAGAC


GCCCCGGATGGGCAGTCAAGGACAATCCGACAGTTCCAGTTTACAGACTGGCCAGAGCAAGGAGTACCCAAAACAGGTGAAGGCTTC


ATCGACTTCATCGGGCAGGTGCACAAGACAAAGGAGCAGTTTGGCCAGGATGGGCCCATCACGGTGCACTGCAGTGCTGGTGTGGGC


CGCACCGGTGTGTTCATCACCCTGAGCATTGTCCTGGAGCGCATGCGGTATGAGGGTGTGGTTGACATGTTCCAGACCGTGAAGACC


CTCCGCACACAGCGCCCTGCAATGGTGCAGACAGAGGACCAATACCAGCTGTGCTACCGTGCGGCCCTGGAATACCTCGGCAGCTTT


GATCACTATGCAACGTAACTACTGCTCCCCTCTCCTCCGACGCTCCCCCGCGGGGCTCCGGAGGGGACCCAGCTCCTCTGAGCCATA


CCAACCATCGTCCAGCCCTCCTGCACGGATGCTGTTGCCGGCAGAGCACAGCCCACTGGGATCACAGCATTTCGGGGAACATTGCCA


CACCAGTCAGAGAGCCCAGAACACCTGGGCAAGTAGGCGGACTGGCAGCCTGGCTCTGGGCCCTCGTCCACCGGGCCAAGTGGAGCC


CCGCTTCAAGCTCTCTGTTCAGCTCCGCGTTCTCATGCTTCTCATGGGGTGGGAAAAGGGGGCAAAGCCCCCACTTTTTATACACTA


GGCGGGGTAGACTGCGGGGTCCTAGCCTCTTCCTCCGACTTTGCTTTTGCAGGTCTTTCACTGCAGATGGGGCTGCTGTGGGAGTTG


GGACTTGTTTGTTTTCCTTTTTGAGTTCACGTTGGATCCTTTCTTGTACAACTTCTGCGGAAGGACACAGTAGTAACTCGCCTTCCT


TGTGCAGAGCTAGGGCCCTACCTGAGCAAGTCGGCTGTGCCCCGGGAGGCAGCGTGACTCCTGCTGTCCTCCAGCCTTTCAGATGAG


ATCCTATTCCAGCCAAATGCAGGGAAACACTTTATTTTGTTTGTTTTAGGTTTTGTTTTTCCTTGAGAGCCTTTTTTTAGGCCCCAC


AGACAGTGGTGGGTGGGGAGGCGATAGGAAACACATTCCCCAGTGTGCATTTAACATTCATAGCCTACAACCACAGACGTGTCTGGG


TTTTTTTTAAGAAAAGAAATAAAGATTCATCCCCTGGCCTCTACTTCAGATTCGAAGTGGGAGGCAACTCAATGTGCCTGGGGCTCG


CCATGGGCCCACAGAGTCTCGCTATCATCCCCAGCGTCGCAGTGTGGCAGGTGTTTGTAGGCTGTGGGTTCTGGCCACCTCGGGAAA


TGAATGGCACAGGTGAGGGCCTGTGCCACGCCCCACACACCTCAGGGCCAAGCGGGGGCGTGGCTGGCCCTTCAGGTCAGGCCAGTG


GGCCTGGTAGCACATGTCTGTCCTCAGCCGGACAGATGCTTTCTCTCCTGGTTTGCAGCTGTCTTCAAATCCCCCCATGACCCGCTC


TTCCCACTCCTTCAAGTTGCCCTCACAAACCAATGTGGCAAGACTACTGGACTTGTATCCATGGTACTATACTCAGTCCTCTTATCT


CAGCTTGCTGAGGGGCAGGGAGAGGGTCTCTTCCTCTGGGCAGCACTATCTAGATAGGTAAGTGGGGGCGGGGAAGGGTGCATAGCT


GTTTTAGCCGAGGGACTCGATACCGACGTCCCCAGATATAGCTAGGCTAAGTCAAGATCAACAGTCCGGGGTTGGTGGTGTTGGATG


AAACATTCATTTTTACCTTGTGGATGCTAGTGCTGTAGAGTTCACTGTTGTACACAGTCTGTTTTCTATTTGTTAAGAAAAACTACA


GCATCATTGCATACTTCTTGATGGTAATAAATTTGAATAATCAAGATTTCTTACACACTAGGCCTCTGTCTCAGCTCCTGTATCTAG


AGTGTGGTATCTTAAGTCTATGGCTGGGGTGGGTTCTGAGGAGTC





MOUSE PROTEIN SEQUENCE: mP28-021.1 (Seq ID No: 65)


MAPEPAPGRRMVPLVPALVNLGLMAGAHGDSKPVFVKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFGDGA


GSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEDQLPSGFPTIDMGPQLKVVEKGRTATMLCAAGGNPDPEISWFKDFLP


VDPAASNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSNQEVMPGGSVNLTCVAVGAPMP


YVKWMMGAEELTKEDEMPVGRNVLELSNVMRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNTEPVS


FYGIQYRAAGTDGPFQEVDGVASTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWE


PPEEPNGLVRGYRVYYTPDSRRPLSAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQANA


ESDTRIQLSWLLPPQERIVKYELVYWAAEDEGQQPHQPLPRR*





MOUSE PANTHER CLASSIFICATIONS


FAMILY (SUBFAMILY)


Unclassified





MOUSE GENE ONTOLOGY


BIOLOGICAL PROCESS


protein modification > protein dephosphorylation


enzyme linked receptor protein signaling pathway > transmembrane


receptor protein tyrosine phosphatase signaling pathway


isoprenoid catabolism > phosphate metabolism


axon guidance > motor axon guidance


defasciculation of neuron > defasciculation of motor neuron





MOLECULAR FUNCTION


protein tyrosine phosphatase prenylated protein tyrosine phosphatase


enzyme > protein phosphatase


protein phosphatase protein tyrosine phosphatase


protein tyrosine phosphatase transmembrane receptor protein tyrosine phosphatase


transmembrane receptor > transmernbrane receptor protein tyrosine phosphatase


protein tyrosine phosphatase > non-membrane spanning protein tyrosine phosphatase





CELL COMPONENT


plasma membrane integral plasma membrane protein


cell > plasma membrane


cell > membrane fraction


cell > soluble fraction


cytoplasm > cytoskeleton





MOUSE PROTEIN DOMAINS (INTERPRO SIGNATURES)


IPR001777 (FNTYPEIII)


IPR001777 (FN3)


IPR003598 (IGc2)


IPR003599 (IG)


IPR001777 (fn3)


IPR003006 (ig)





HUMAN GENOMIC SEQUENCE: hD28-021 (Seq ID No: 66)


GCGTGTGTGGACTGAAACCCAAAAGCCAGAAACTCTCTGCATGTGTCCCTCATGGAGCCATATGGTCTCTAGTCTCTGTTTTTCAAA


ATTTGCAGGACTGATGACTGATTGGACAGTGGTGCAGGAGGGAAGGTCTCTGCATGTCAGTGATTAAATTGCTGAAGATGCCACTGC


CTGAGACGGGCAGTATTGAAGGTAAGCAGATCTGGGGTGGGCGGGACAGAGGAGGCTCTTAGTTATATGGATCTGGAGCTCACAGGA


GCGGCCCAGACTGGAGATAGAGACTTGGAAGTCATCAGCATATGGTTGGTAGTGGTCAAGATGATCCAGAGAAAAGGGGCAGAGCAG


GAGAAAAGAGGAGGCCTAGGACAGAGTCCCGGAAGAGCAGAAGACGAGGTGGTAAAGGAATCAGAGACAGTAGCCAGTGAGGAGAGG


GTGGGCCAATGAAGCCAAGGAAAAGAACTGTTTTAATAACTCAGCAATGGGCAGGAATAATTGGCTGAAAAGTATACTTTTAAAATT


TGGGGGCCGAGAGGGAATCTCTAAATCCTCAAAGTTCTGGAAAAAAAGGCAAAAATGCTTAAAGATGCATAAAATTTGCAATACCTC


CCCCGTGGTGCACCAAAATTACCAATGGTGAAAAACCACTCACTGGAAATATTCATTTTTGATCCGTTTGTCATCCAAACCAAATTG


TCCAGAATCACTGGAGCCAGTCCCATCCCCTCCTCATACGCCAGGGGGCGCACACGCACTGTTTGTGAATTCAAGTTCAGGACAAAA


ACAGGCAGTGAATCAGGTGGTTACCAGAACCTGATTCCTCAGCCCAGATCCCTGAACACCACAGCAACCATGCCCTGCACATTACCA


CGTGATCCCTGAATCCAGGCACCTCAACGATCTCCAAATTTTATTTCTCACCTGACTCCAAACTTACAGGGTTATCAGAAAGACCCC


ACAGAAGAAACCCCACAGAGGAGAAACCTCATCTCTTTTTCTGCTCAGTTACCTGACCCAGGGCAGTGGGGGTAGGTCCCCCATCCT


TCATGGTGAAGCCTAGCAAGCGGCGGGGGGAGGAGGGGTGGGGTAGATAGGAAAGAGCTGGTGTGGCTTTGGCTGACTCTTAAGTGG


TTTTAACACGGATTGCGTGGGGGCGGGGTCTGGAGGCAGGGGCGCTTGGATTGAAGCTCATCAAATCCCTCTGATCAGTAGGTCTTG


GAATAAATCTTCAGGTAGGTTATTGGTTTCACCCAGAAATTTCTAGGGTCATTATTTGAGTTTGGTATGAGAAGTCAGAAACTCAGT


ACTGACATTTAAATTACATTTAGAGGGCATTATCATGTCTTTAATTCCGAGGCCAATGTAAGGTTCACAGCTGGAATTGGTATAATA


TTGGGGTATTAGTCAGTCTCTGCTTGGGGTTGACACTAGGTCAGAGAAGTGGAGGGTGAACATGAGGATGAAGGGGCTTTGTGTGGA


GTTTCTGCAAAGCCAGTCTTATCTTGGGTTCCAAGATTATTATTAAAGCTGGGTTGGTTTAGGGTCCTAAATGGTCTCAAGTTTGGG


TGGGGTTTCAGGTCAGTATCTGTGTTTGGGGGTCCTTTTATGGTGACCCAATCCCAACTCTGGAATTGAGAATCGARTTCAGAGTGC


ATTGGTGTTGATCTGGGAATGGGAGAGCAGTACTGGAGTTTTATGTAAGGCTTGGGGTTCAGAAGAGAGATAACTGGGGTCCATAGC


AAGGTAGCTTTTGGACTTTAGGGTTCATTTAGGGACTGGGGGCTGAGCATTAGTACAGGGTTCCATTTAAGGTCCAGCGTTGGTGCT


AGCGTCACTATCAAGGTTAGGGCAAGTAGAAGTAATAAAGAGATTTAGAGTCAGAATTGGTATTTGGGATCAGTATAGAGGTTCACA


ACAAAATTACTACTTGTGCTAATTTGGGGGCAGATTAAGGGCTTTGGACTCAATATTGGGTTTAGGGCAAGGTGTGGGCTCAGTATC


AGGTTCAGATCTGTATGGGGAGGAAATGGGGTCCTAGAGTGGTATTAGGTTCATGCTAGGGCTGGGAGCCACTAGAAGGATCTGGAT


GTAGTATCACAGTTTGGTCTGTCTATGTTCATTATTGGGGTTCGGGTTCAATATTGAGGTTCCGGTCGGTTTCGACTTGGCGTTGGG


TTGTGGCCTGTCTGGGCCTCAGCGGCTCCGCGGCTCTACGAGCGAGAGTGCACGAGGGGAGGGGCGCCGCCGGGGGCGCGCACGGCA


GGGGCAGGGGCGCGGGCGCGAGCGCGAGGGGAGCGCGCGGCTCGAGCTGGCGCGGGAGCGGCGGGAGCGGTGGCGGCGGCAGAGGCG


GCGGCTCCAGCTTCGGCTCCGGCTCGGGCTCGGGCTCCGGCTCCGGCTCCGGCTCCGGCTCCAGCTCGGGTGGCGGTGGCGGGAGCG


GGACCAGGTGGAGGCGGCGGCGGCAGAGGAGTGGGAGCAGCGGCCCTAGCGGCTTGCGGGCGGACATGCGGACCGACGGCCCCTGGA


TAGGCGGTGAGTGACCCCCCGGCCCCCCACCAGCCCCCTCCGCTCCCGTCCCTTCCCCGCTCTCCTTGCCCTCCCCGCTAGTCCACC


CGGCGGAGCTGGGGGCGGTCCCGGGGGGGACGAGGGCGCCGCTGAGGCCGGGCCGCGCCCCCACCTGCCGCGCCCGCAGCCTCGGCG


AAGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN


NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCCCTCCCAG


CCGGCGGGGGATCCGCAGCCGGCGCGCCCGGGTCTCGCTCGCGGCCCCGGCGCACGTGCGGTCCCGGGCTGCGCCGGGCGCGAGTTT


GAAGCCCCCCCACCCCCTTCGTTCGCGAGCACGGGATGGGCAGGGGCCGAACGGGCTGTACCCGCCCCCAACCGGGTGCAACGCCCT


GGAGGCCCTGGAGCGACCTGTCCCGTGAGGACGTGGCCACTCGGACCCTCTCCGAAAGTTCACTCAGTGGCCGCCCCGCGTCCCGTC


CCGTCCCGTCCCGGCTCCCCATCGCCGTGCCGGCGTCTCTGTCTCGGCTGCTTTCTGTTTTCCTCGGCGTCTCTGCCTCCCCGTGTC


AGTGCCTCCCAATCTCACGCCCCTGCAATCCCAGGGTCTCTCCAGCTGTCTCCATTCTTTTTCCCCAGGTCACTCTGTTCTTTCTCC


CCAGGTCTCTCGATTCTGTCTCCCTGGGTCGTCTTGTTCCCTGTCCCTGAGTCTGTTCTCTCCGCTTGGGTCTCTCTATTTCCTCTC


CCTGGGTCTCTGTCTCCCTCCTTAAGTCTCTGCCTCTTGTCTCTCACCCATCTCTTGGTGTCTCTGCACTCTCTGTGCTAGGCGCCC


CCCCATTTCCCTGGAATGCTGCCCCTCTGGTTCTTCCACCCCGGAGGGGGAGGGGCTAGACTTTCTCCCCATTTCAAGCCCCCCTGC


CCCCCAGTGCACGGCCCCTGAGTTGGAGCAGGTTGGGGGTGGGGAGCGCTACCTGCCTGAGCTGTGAAATGGGAGAGGGAGGCTGCC


CCAGCCTGGGGGTTGTCTGGATCTCCCTGAGGGGCCACAGGGCAGGGCCGGGAGGCTGGATTAGGTTGAGGAAGGCTCCACTTTTGA


AGGAACAGGGGCAGGGATCCAGAGCGATCTGGTGTCGGATCTGGCCTGAGAAGCAGGGAAGTGCACTGGGGTGAGAGGCGTAGAAAA


GGATGTGGGGTGGTGGTTCCAGGCGGGTGCTCATGGGGAGGAATCTGCTGAGAAGGGAAGATCTGGTGGGGAATCCTTTCGGAGGCT


TCGGGGATCTGAGGGATCCAGAAGAGAGTTCTGACAGGCTATCTAAGGAAATTTCTGTGCTTAGCTCCTTATTAACTCTTGCTTCAG


GGAGCATGAAAATCCCTGTTTTTTACTGATTATATGAATGAGCCTAGGGCTTCAAGAAGGAGCAGGTGTAACTCCCCAAGTACAACC


CCCTACATTCTCAGCCCCAGGCACAGGCCACACTTTCTCGTACCCTCTTGCCTTCATTTCCACACTCAGCTCACCCCCTCCACCCCC


ACACACACTCCCTATTCAGCTGCTTTCTTGCCCCCTCTCGCATACCTGGGCCCGCATGCCGGCCAGGGCTCAAGAAATCTGTGCCTG


CACACTCTCGCAGCATACCTGTGCACATGCACAGTCATCCTTGTGTATTTTTGTATATGCACTTTCTTGCACATTTTACTTGCTCAG


TCTCTTATTTGAAATGTCTTTATAGTGTTTTTTTTAGTTTCCTTTATAGTTTCCTTTTCCAGCTGCTCTTCCTCTTCCCTCTTTCTT


TCCTTTAACAAGAAAATTGTTTTAACATAATTCCTTCCTTCCTTCCTCCCTTTCTTCCTTCTTCTTGCAACTACTGATACCTCCCCT


TTATCCAGCTTTGTGTGCCCTGGGCGGGTTGGCTTGGTGTACAAGGCTGCCAAGAGAGGAGGGGGTGGTTGGGTGTTGGTGAAGGAA


TTTGGCGGGGCAGAGTTAGACTGCAGCAAACGGAAACTAGCTACACATCTTTTACTGGGAAGTGTATGGATACGCAGCAAAATACTA


GCCCTGGCAGTTTGGGCACAGTCCACCCTTTTTTCCATCAGCCTGAACTATGGGAGTCTAGCTTTGAGGGTCCTCCCTGGGGGCGGG


GAGGAGGGGACCCAGACCTCCTGCAGTAGAGGGGTTGTGATACACACCACGGCTCCTCCACTTTCCAGCTTCAGGCCTCAAAGAGGC


CCCTTTCTCCCTGAGTCTCAATTTCACTCCCTGTAAAATGGGGTAGCTAATCCAACCCGGACTGGGTCCCAGGGCTGTTGTAAGAAT


CCAAGGGAACTGTGTGGCAGTGCATCGTCAGCAGTGGCAGTCACTTCCCTTGTGACTGACACTGCTGTGTGCTTGGTTCCAGCTTGC


AGTCAGGGCCCTACCCTCGAGAAGCTCGTGGTCCTTGGGGGAGCAGGTTGCACCATGGGATTGCAAAAGCAATTCAGTTACCTGTCA


TTGATTGCTGACTGTGTGCCAGACCCCGGGGTAGGCGCTTTCGGCCCCGGCTGCCTTTCTTCCTTTGGGACTAACAGCTATGTAGAA


GAGGCAGCCCACCCCTAAGGTTCAGGCATCTGCTCAACTAAAGCAGCTGCGGTTCTGAGTTGGGTTAGAACATTGCAAGAGTTCATC


AAGAGACGGGGGAGAGTTCGGAGGTCAGGGTGAGGTGAGTCCCAGAGGAGACCAAGAAGAAGTGATGTGAACTAGGTTTGGAGGGAT


GAGTAGGAGTTTGAAGAAGAGAGAAAGGACTTGAGATAGATAAAAACCAGTATGAATAAAGACTGGGAGGTGTTGTCACTTGTGAAG


TATTCAGAGATGTGGCAGATCACAGAGGGCATTGAATGCCCTGTTAAGTACCTGTAATTTTACTCTGAGAACCCAGAGAGAAAACAC


CAAAGGTTTAAAGCTTGGATAGGGAGGGTGGAGTGTGCTGTGGTCAGGTTTATGTTTCCAGAAAATGCTCTGTGGCTATCGGAAAAG


GATGGAGACAGGATGCCCAGTGGGGCAAGAGGGTGCAGGTAAGTAAGGTGAGAGAAGATGCTGGCTTTGATAGGTGGTAGCATGGTG


CCATCTTGAAGGTACACTTGTCAGGACAGAATGATTTATTGGATGTGGGAGTGAAGGAGAGGAAGAGGAAGGAGTCCAGGTTCCTCG


GAGTGGTTGAGCGGGCCTTCACTGAAGGCCCTGAAGCTTCACTGTGTTAGGGACTTGGTGAGGAGGGGCAGAGAATAAGCTCTTAGT


TGGACATGTGGCCCTTGAGGTACTTGGGACATTGGAGGCTCAGTGGGGGAGGCACATCAAGGAGGGGCTTTGGTGTGAGGGTATGGG


AGAGAAATGTCGGTCGGACCAAGAGAAGCGAGAGCTGTATGAGAGACCATAGAGCTGTGCACCTCGAGAGAAAGTAACCTCCGACAG


TGGTGAAGAGCTCGAGTTTTATACTGCTAGGATTGGACTCTGTTTACTAGCAGCGTGACTTTAAGCAAGTGGCTTAACCTCTCTGAA


TCCGCTTCCTCATTTGTCAAATGATTATAATAAAAACCCGTGCCTTATAAGGGTTGTTATGAGGATTAAAGATAGTATGCATAAAGT


GTGTGTAGCACAGGGCTTGGCATCTAGTGAGTACTGTTGTCTGTGTTTGCAGTTACTGTAATCATCCTCAACTGGGATGGTGTAAAC


CCACCCTCCCATCAGGGGTCACATGAGGTTGCCTTTAATGAGAAGATAGACTGCTAAGGTTAGGGTCCCTGTCTGCCTAAGGTTGCT


GCAATTCTGAGCTGAGATTAGCAGGTCAAGGAGCTCAACAAAGGGGGTGCCTGCCCCTATTGTTATCGATGGGATTGTTTGTGTTGC


TCAGGTGTTTGACCTTCAGGTGGGTGGGCTTGAGAAGACTAGAGGTGAGGCCTGCAGAAGAGACTCCATGTTTGGGGTAGGTGGAAG


GGAATTTTGAGAAGGGGCAGCCTTGGGGTATTGAGTTCTCCATTTCCTCCCACCCTCCCTGGGCCCTGGGCTTCTACTGAGGCTCTT


TCTGCCACCATCTGCCTCTGTGGTCCAGATGCACCATGTCTCTGTGTGACCGTGACTTCTAGGTCTGAGAACTCTCGTTTTAGCTCC


TTAGCAGTATTTTAGCTGCTGTTTCTGGGGACTGTTCCTGGTGCAGCCACAGGGGCATTCTGGGGGTTGCTCCAGAGGGCACCTGTG


CCTGCATTCCCCTAGGTATCATCGACTTGCTCCTGACCCACTGCCGGGCCAGGTTTCAGGCCTGGCAGATGATGGGGAACCCTACTG


GGGCCAGCCCTGCGTTGGCCCCAAGGGCTTTCTTTCTTGATATTGGACATGACTGTGGACTTCACCCCTTCTGAGGCCTTCCTGGGT


GCCAAGCAGTGTGATTTCTTTCTTTTTCTCTTTGGTTTGAAACAGAATCTCACTCTGTTGCCCAGGCTGGAGTGTAGTGGTGCAGTC


GTGGCTCACTGCAGCCTCCACCTCCTGGGCTCAAGTGATCCTCCCACCTCAGCCTCCTGAGTAACTGAGACTACAGGTGTAGTCCCA


CCTGGCTAATTTTTGTATTTTTTTAGAGACAGGGTTTTGTCATGTTGTCCAGGCTGCTCTTGAACTCCTGGCTCAAGTGATCCACCT


GCCTTGGCCTCCCAAAGTGCCGGGATTACAGGGGTGAGCCACTGTGACTGGCCAGCAGTGTGATTTCTAACTTGGGTCCTGAACCAT


TCAGGCCCTTTCTGAGTAGCTTTCTAGTCAACCTTCCAGATGTCAGCTCTGGCTCTGTTCTGGGGGTGTATCTGGTTGTCCTGGTTG


TTCTGGGCTCTGTCCCAGTGTGAGTGTAGAGTGGGTTCTGGGAGCTGCAGTTGGTGAATCTGAGTCTTTATTTGGTTGCCTGATAGG


TTGTTTTGAGGTCAGTTTGATCCCAGACTGACGTGGTTCAAAGTTACTGTTTGGCTTTTCTAGGATCCTGCCCTCATGCTGTTCTGT


GTGCCTCAGGGTCTTTGCAAATGTTTAGTCTTCTAAAATGGCCCCTGGCCACTTTGGGTACACACCTCTTTCCAGGTGTGGCTTCTG


CTCCATGTAGGGCCTGTCTCAGTCTCCAAGCACGAGACCCTGCTGTGGCTGGGTGTGGCAGCAGCGCCTGGCCAGCTTGGGGGGCCT


TTCCCATTACCCAGTTCCCTGCCTTGGACTCTGCCCCTCTGCCCAGGGTCTCTGCACAATGGTGCAGCCAAAAACCTCACTTGAATA


CTGTGAGGCCCTGCGGGCATCTCTAGACAAATGGGCCTTTAAGTTTGGGGCCTGGAAGCTGGTTTGTCTGGCCAGACCTGCTGGGCA


GCCTGTATGCTGGGAGCAGCAGCTGCTGGAAACTCAGCTTGGGGAGCGGGGAGGGAAGCATGCAGAGAGGGCTGCGGCTTCTGGTGC


AGGTAGGTGGGGCAGTGGAGGCTGGGTCGCCAAGCTGGCGAGGGCCATCTTGGGTCAGTTGGGATGGCCTTCAGTCGGTGAGAGTAC


CCCCATATTGGCAGAGGTGGTTAGTGCAACTTGAGGGTAATTCCCAGGTGCAGAGGTGTGTCCTTGATTTCATGATGAGGGTCAGTC


TTGGGCCGGTGAGGACATTCCCACGCACCACCCTCCCACTGTGGTTTCTTTGTGTCCGTTATAGGAGGAGCCAAGGTGGCAGAGTGG


TGTGGGGTGGGGATCACTGTGCATGTGGGGGCTTGAGGTGAGAAGCCTGCTGCAAGGTGCAGCTTGCGTCGAGTAGGCCAAACAGCT


GAGCTTCCGTGAAGTGGTGATGAGGTGGTATGGGTGTGTCTGACCCCCACCCCCACCCAGGATGGTACCCACGCTGGTGGGGACTCA


ATAATGGCTCTAGAAGGAAGGGGCTGGGCTCTGTCGCTGCATGTGTGCCAGCAGAGGAGGCATCCAGGGGCACGCCTTCATTTTAAA


AATTATAGAGTAGAGAAAGTCAAAAATAAATATTGCTTCTGAAGCTTCTTTGAAGACTGGCATGTATGTTGGGGTGTGTTCTTCCAG


GCTGGGCTGTTTTCTTTGAACTCATTCATGCGTTCATCCACTCATTCAGTGTATGCTGACTGAGCACCTACTATGTGCCAGCTGTCA


GCCAGGCGCTGGGGATACGGAAATGAGCTGGGCAGCCACAGTCCATGCTCCTATCAAGCTTATGGTAGTGACTCAGTAATTGTAAAA


ATATATAAATAGTCATGTTTGTGGTCACGGCTCCAAGCCAAGGTCCAGGCAGGTAGTCTGGGACATTGTGGAAGGCTTCCCTGAGAA


AGTGCCACTGGACTTGAGATCCGAGGGTAAGTTGGCCAGAAGAGCATGGGTAGCCTGTGCCAGGCAGTGGCATTCAGCACTGGCAAG


GCTGGGAGACAGGAAGAAATTTCGCACATTTGAGGATCAGAAGAGGAAGTTCCCGTTCTGGCAGGAGGAGAGCATGGGCAGGTAGGG


CTGCAGAGGTGGGAGGGGCCGACTCTGCTTGGCTCTGGGGTCATGCTGAGGAGCTGGGCCACAGAGTCTACTGCTGAGGTCAGGGAC


TTGGTCTGTGTGGCTCACAGCTATATGGCTGGTGCCTGGAAGGACGCCCAGCACATAGTAGGTGCTTAGGGAGTATCAAAATGAATG


AGCGAGGGAGTGAAGGGAAAAGATGGGCATTTTTACCAGATGGGGATGGTTCTACATGAACATTTCCATAACCTGCTTTTTTTTCTG


CATAAACAGCAAATTTTTAATGTCTTTCTGTGTCAATACATATGCTGTTGTGATGAAATTCTTGATGTTTTCTCATGCTTTCCTTTC


TGTCCAGGAAGGAGTGGAGGCCCTGGTGCCCGGCCCTTGGTGCTGAGTATCCAGCAAGAGTGACCGGGGTGAAGAAGCAAAGACTCG


GTGAGTGTGCCCCACAGAGTGGCCAGGAGCAGGGGTGCACAGGGGTCCTATGGACCAGGCTGAGCAGCTTGGATTTGATGCAGGGTC


AGTGGAGAGCTATAGAGGGGGTGTCAGCAGGGGGCATGACATGATCCAGTGTGCACTGGTGAGAGATTGTGGAGGCCTGGACCAGGG


AGGCAGTGACAGAAGTGGAGAGAAGGGATGTGAGTGCTATTTAGGGAGGTAGAGTAGACAGGACGTGGTGAAGGATTGAATGTGGGG


CATGAAGGAGGGGAGGTGTCAAGGATGGTGCCTGAGTTTCTGGCTGGAGTGGATGATAGAGGTGGATGGGGAATGACATACAGCTCG


TCAGCTACTGTAGGTGTGAAATAGGCTTCCGGGTGATGTCCTGGGACTTACACCAGGATCTTTCTTCTGCTTCTCCATTCACCACGT


TTCTGTAGAAAAGACTGTTCCCATCGACTGTAGGTTGTCGTAGAAAGAGCTTGGTGCCTGCAGGATCTCGGCATGTCCTCTGCATCT


CTTTGATGTCCCCTTGTTCTCCTCTCTGTCTGTTAGAAGCACAGAATGGGTGGGCTGGAGTTGCAGGGAATGAGGTTGGTAAGTTGG


TTTAGAGTCAGCATCATGGGCCTTGGATGTCAGGCTAAAGACTTTAGACTTTTTCCTGAGGGCAATACAGCAGCATTGAAGGTTCTT


AAGCAGAGAAGCAATATCCATGTGTTGATCTGTCCATTGCCCATCCGTTCATTCTTTCACGGAACACTGTCTGAATGCCTGCTGTGA


AATAAAGTGGCAAACAAAAGTGCAGATTTGCATTTTTATGTGCTGAAAGGTGGCACTGGTCTGTGTGCGGGATGGGTTGGGAGTGAT


TGAAGGCAGGAAGCCCACCAAAGAGGCAGGAAGTGATGAGGTCTTACTAACACAGTGGCAGTGAGGATGGAGGCAGGTCAGATTCAA


ACTTATTGATGGGTTAGATGTGTGGGATGAGGACAAGGGAGCATTTAAGGAGGGTTTGCGGGCTTGGTGACTGACAACATGGTGGTG


CTGTCCCCAAGACTGGACACCCTGGAGGAGGAGTGGAATTGGGGCAGATGAGTTCTGGTTGGGCCATCCTGAGCCAAGAGCTCGGTG


GGTCTGTTCACCCTCTGTAAGCTCCTCGAAGGCAGAGCCTGTGACTCTCTTGTTCATCACCCTGCCCACTGAACATCTGGACGGGTG


GCTGAACTAACAAGGCTGTGGAAGAGATGGGTCTGGCCTGGGTAGGGGAAGGAAATGTGTATGTCCTGGGTGTCTCCTGGGGTCCAG


ACCCTACGTTTGGTGAGATGGGCACTGGGGTTATGTAGAGGGTGCAGCAAGAGGGGCTGTGTCACAGGCTGGAAAGGTCAGATGGGG


AGGGTGGGTGTAGGGACACTATGTGTCCCTTTGCCTCTCCATCCTCAGATGATGGTCTGACCTAACTCGAAGTCCAGTCTTGCCAGA


ATAGGTACCTGAAGGTGGAGCCCTCTGTCCTCTCGGGAGGCCACTAGCTGATGGCATGTCTGGTGGGGTGCAGATGGGGTGTGCTAT


AGGACCTGACTTCTGGAGGCTGGGTAGGGCTGATGTGGGGGTACAGGGGAAGATACTCTGAGATCCTGAGGCCACGCGCCAGCAAAT


ACAGGAGTTAAGCCAGGTTGGAGCTTCCTTGGGTACAAGGCCCAGGGTGCCCACAGGGGATTGGGTTCTGGGGCAGGGGCCAGGTCA


GGCTCTAGGCTCAATTGGCAAAGGATCTTGTTGTCTGTGTTGGGGTTTCTCAGCCTCAGCACCATTGACATTTTGGATCAGATAACC


CTTATTGTGGGGGCAGGGCTTGTTATTGTAGGGTGTCTAGCAGCATCCCTGGTTTCTTCCCCCTAGATGCCAGTAGCATCTCCCCGC


TTTCCCCAGTCTCGACAATCAAAAATGTCTCCAGTCGTTGCGTAATGTCCCATGGGGGCAAAATTACCCTGAATTGAGAACCTCTGG


TCTACAGCCTCTTGCTGCTTTCACTATACTGTACAAACCTGGAAAATTGGGGAGGGTCAGTGGGGAAGATGGATAGTGATGGGCCAC


TTGAGCAGAGTTCTGAGGGGTGAGTGAGTGCTGGGGCAGGAGAAGGACATTTTTTTCCAATAGACAGAACGGCAGGTACAGAGGCTT


GGAGGCACAAAGTTGGGAAACAGTAATCCAAGGGGGACCCCAGCCCCAGAGGAAGGGGCCTGGAGGCTTAGGGGTTACAGCCGCAGG


AAGATACCTCTGCTGGTCCCCTTTGGTCATTTGCCTCCAGAGTTAGTCTCCTGCTGACCCTTTGCCGCCTCCAAGTCTCTGCGACAC


TCCTCCTAATCTCCCCCTCCACTCCTCAGTGAGATGGAGAAGCTGAGAGCTGCAACAGGGTGGGACTCAGTCCAGCTGGTGGGAGCC


CCGATACCAGCCGTGGGAGGGAGGGCTGTTCCTGGCTCTGCTCACGGATTCTGGCCAACTGGCTGGAGGAGGGAAGGCGGCCTCACC


CTCTTCCCCACAGGCCCCTCCTTCCCTGGGTCAGGGGTCCTGGCTGAGACTATAATTTATTCCCGTCATAATCCAGTGGTTGGTTTG


GTGAGAGCTGGAAACATGTTGGTTTTCCCTTCCCAAGTATAACAAGGCCTGTTTCCGCCTCCGCGGCCGCTGCTGCAGTGCCACGCG


GTGAACTGTCCAGGACATGACAAAAGGGCTCGGTTAGCTGCCCGCTGGTTAGAAGATGAACGGCTCAGAGCTCTCCCTGCCGACAGG


CTCTTCCCTTCCTGTTGCCCAAGTGCTGGCCTTTCCTCTTGGCCGTCTGCTCTGTAGGGCCCTGGATACCCCTCCTTCTGCTCATGT


CCATTTCTGGGCCCCAGGGTCCTGGCCTGGGGAGGTGAGATGGGGGAGGCTACAGAAACAGGTGGTATTTGGAGACTAATTAATATT


TGTGAATAATAATGCATGCCCAAGGAAAACAAATCAATCTGTGTTTGCGTATTTATGATGAGGACTCAGGAATGATCCCAGCTGTTC


TCCAGCCAGGGAAGCCCCCATCACATGGTCCCTTGGGCCCCCACAGAGGCTGGCAGGGTGGTTAGGGTGGGCTGCATGGAGGTGACA


TGGCTTCTGTGTTTTGCAACGTGAATCTTCTGTGACGTTCATATGCGAATGCTGTGGCTTGGTCTAGTGCCTGCTTCTTCCTTTTCC


CTCAAAGCAGTGATTCCCAGGCTCTTTGGTTTCACGAACCAATACAATTTCCAAAAGTACTCAAGAGCCAGACATGGGGTTGGCAAT


TTTTTATTTTGCCAAGTAAAGGCATTATAAAACAACTGCTATCTGCTGTCCCCATCATTTCATACAGGAAAAAAGAACATTTTAACA


CCAAGGACAATATTTGAGAATAAAGCAAGAAAGGGCAGTTGGCAGCTTTACACTGACGTAGCAAAGGAAAAGGATATATTAAAACCA


TTCTGAATGTGGAAAAATTGTGTCCAATTATATTCTATAATATCATACCGTATGTAATTGTGTTCCTGCCCAAGTATGTCAGCTTGG


CAGAACGGATGGTCCACAGTGCAATTCAGAGACGAGCTTGAGTGCCCCAGTGCTCCGGCCTTGTTTTTATCTCGGTTGTTGAAAGCC


CAGGCTCACCCAGCCATGCTGGTGAAGTGGGTGCTCTGCTGTGAACACCGTTGCATGGATTCACAAGATGCTCAACCTCGCAACCGC


AGTCAGGCTAGCAGCAGCCCTGCCCCTTGTTCCTCTCCCACCTTCTCCCCACAGGTGACCCTGGGACCCTGGGACTCTGGGGGCCAA


GGTCTACTCTTGAGGCCAGGCCTGGGGATCCAGGGCTGCTCTGCTCTGATGAGGGAGGCCCTGGAGCTGGGAGTGGCCTGAACCGCC


TGACACCAGGGCAGGCTCTGTGCCCGGAGTCTCAGGGCGGGAGGCAGCTTGCTCTCGCCAGGAGCTGGTGAGGGAGAGGCCCTGGCT


CGTACAGCTGTGTGGCTGCCAGAGTAGTTGCCTGAGAATGTGTTTGTGTGTGTCCCTTGTGTTTCCCCATCTCCCTGGGCATCTGTG


TCCTTGTGTCCATCATGGACCACTGGAAGAAGCTCTCTGTTCTACTTTCTGGATCTGAACAAAGTGTCCTGAGCACCCCAACCCAGA


TACACAGGGGGTTTCTGGAGGCCCCACGTTGGGGGTAGGGTTACCTGAGGCCCAAGTTCTCCAACACCCATGGCCAGACTCTCATCC


AGGCTTGTACCACATGGGTGTCTATTCTGGGAGTTTTACCCCCATGATGGCTCTCCTGGGAGCTCTGCCCCCACCATGAAGTCTGTA


ACAGCACGTTACACCTCTGCTAATGTATGGGGAGTTGCACCCCTGTAATGTCCTTATCAGGCAGCTGCACTCCATGATGTCTGTACC


CTCTGTGTCCGCCCACGTGATGTCTAGACCACACCATTACACCTCCATGATGTCTGCACCTGGGCGTTATACTGCTATGATTACTGC


ACCAAGGCGGCTACAGGGGATTAAGCCTCTGCTCATTGTACTGGGGAGCTATATCCCATGATGACGGTGCTGTGCATTTTATTTTCA


TAGCAGGGAGATATGCTCATGCTGGGGGCCTATGTCCCTATGAAGCCTGCCTGGCAGGGGTTGCATGCTTGGAATGCTTGTTCCTGG


AAGTTAACCTCTGTGACTATTATATTGTTATACCCGATGATGCCGGTACGAGGCCACTGTGCCCTGTCCTTTGGTGCAACACAGCTG


TTGAGTTATAAACTCATGTGTCTCATTCAGGGGCTCCAGGATGGTCCATCAGGGGACCATACCCCCATGATGACCTGCCCTGGCATA


GGATACCAGATGTGTCCACAGGCCCAGGGAGGAAGAGCCACTCATAGTCCACCACCTGATGGCCGCTGGGAAGGTGCTCCATCGTTG


GCTGCATGTGGCACCATAGCGCAAGCTCAGGCAGGGCCTTGGTGATGTGTGACCTCCATCCCACTGTGGCCTTGCAGGCGTCATTGT


GGTCTCAGCCACCTCAGCTCTGGGATTGTGGAGCAGATCCATCCCCAGCTTGGTGTAAATGGGGCTGGACACCTATCAACGTTCTTA


CTTGAAGAACTGGTGTAAATGAAGGCTGGACACCCTTCACCGTTCTTACTTTGTTGTTCAGCTCCTGTCTCAGATTTTTGGTGGGAT


CCTGGGACAGGGGACAACTCTCACCCCTTTTCCTTTGTGTTTGGCCCCATCCCACTTTGCATTCCCACCTGCTTTGTCCAACACCTT


TGCTCAACTGCTGCCTTCTGACCTCATGAACTTTGATTATCTCAGTTGAGACAAGGGTTCAAATTTCAGAAACGACTGGAGCACCTT


TGAGCCCTGCCCATTCCTGGTCACCTGCCCTGTCACCTTGCAAATTCTCTTACTATTGTGGGTCAGCGGGGACCTGGGTCTGATCAC


AACTCCCCTATCAAAGTCCATGCGTATCACTGTGGGGCCCCAAGGCGTGTTCACCGTCATGCACTCTGCTCTGTTGCGTCTTCACAG


CATTCATGAGGGATCGACCACGTCTCACCCCTCTGCCCAGAGCATGGTGTGATCAGAGCTTGTGGGCCCTTCCATACATCCCCTGGT


GCCCCCCAGGTGAGGGGTATGGGAGAGAGACCCTGGGGAGCTCACCAGTGGGGCCAGGGAGTGATAGCAGCGTATCTCCCATGTATA


GTGCGGCCATGCTAGAGGCTTCACCCAGGTGCCTGCAGGCACTTCAGGCCAGGAGCCTTGGAAGTAAAGGCCTAGGGGCATTCAGCC


AGTCCCAGACGCTACTCAGTCTTTTTGTGCATAGCTTCCTGTCTCAAACATCAGCCCCTGAGGTTCACACCCCATCATCCCTACACT


TGTTTGGCTCCGGGCTTCTGGGGCAGGGCAGAAGAGATGTGAGGTTTGAATTCTAGGGTCTAACACCCCATTCCATGGCCACTGAGG


CCTCCCTGTGGTTTCTCTGTGAAGTAGGAAGGTGCCATGGGAATGGGTAGGACGAGGGTGGCCAGGCAGGGCAGCAGCAGCTTGTCA


AGAGCACGTCCTGGTGAGCACTGAGGGGTTGTGGCTTTGGCTGGAAGCCTCTGATACCTGGAGCCTGTCTTCTGCTAACAAGCCTGT


GTTCAGGGGCCTGTGCTCAGCGTGCTCGTGGAGTCTGGCCTCCCACCTTCTCCCTCCCTGCTGGGGAGAGGAGGGGCAACAGAATTC


TACCAGGGAGACTCCAGAGTCAGTTGGCTTTGCCCCTCACTGCTCCTTGTCACTGTCTTGTCTCTCTGTCCTCTGTCCCACGTAAGC


GTCTCTCTGACCCTGTTTCCCTGTCCTCTTATGGGGGTGAGTTAGAAGCTCAAGGTTTGGACTGGAACACACTGTACATCCTCTGGT


CTCACTCACTCCCTGTACCTCCTACTCAGGTTTAGAGAATGGCCCGAAGGCCTCCTGCGCTCTTTCTCCCTCCACCGTGACTGTTGG


GCTGTCCTTGTGGGTGCTGGGGAATAAGTGAGGAGCTTGGGTGGTCACTGGGGTCAGAAGGTCTAGGTGGTCATTGCACAGCCCAAG


TGGGGGGCTCTGTTGAACTAGGCTCTGGATGGTCAGTGAGGATGACTGGGGGTCAGAAAGCGTCAGGGGTGGGCATTAGGGACAGCA


GTAAATACCAGCTAACTGGCTCTGCCCTTCTCTCCATTACAGGTTGATTGTCCTGGGCTGTGGCTGGCTGTGGAGCTAGAGCCCTGG


ATGGCCCCTGAGCCAGCCCCAGGGAGGACGATGGTGCCCCTTGTGCCTGCACTGGTGATGCTTGGTTTGGTGGCAGGCGCCCATGGT


GACAGTAAGTCTGACCCCTCAAGGTACAGATCTCCCAGGTTGAAAGGTGGCATCCTTCCCAGCAGGACTCTGGGATGGGGACAGACC


GGCTACTAGGAGAGACAGGGTGGCCAGAAACCCTTTAGACCTTCTGTCCTAGAGAGCCCCCACTGCTTGGAGAGCCTCCTTCTAAGG


AATACCTGGGTACTTAGGAGCATCTTTAGGCACCAGAGCGGGGCAGTCGAATCGTGACCCTGTCTTATGGGGCTGGGGTGAGACCTG


TCCTGGATTCATGTGGTCATTGTGTGATGTGCGCGTGTGTGTGCTGTGTGCACTGTTGCAGATCTGTGCTGAAGGCACAGTGTGAGC


TACAGCCAGGGGTCGGCATGGGAATGGGGGGTGGCACGCAGGGCATGCGTATGGATGTGTGCCCAGGACGCGGGTGTGTCCATAGGC


CCAAGGAGGGTCAAAAGCGGGAGCCACCCATAGCTCTTCCCCTACGCTGGACCCTCAGGATCCAAGTATGCAGATCTGAGCCCCTCC


TTCTCCTTTCATGGGGACCTTCTAGGCAAAGGAGCATCCCCCCACCCCAGCTCCTCAGACCTGGAAATGGGGGGAAGATTGTGTTTG


GCCGGCAGGAAGCTGAGCAACGCCCCTCTGTGTGTGTTTGTGTTGGAGGGAGGTGGAATTGTCCCCATCCAGATCCAACTCCGAACT


TTGGTCCCTTTCCTGCTGCCCTTCCCCCTGCCTGGCACTATGAGACTGGCCTCAGCCCGCCCCATCGCCATGGTTACCACTCCTTGG


TTACTGGTGGGAGGCGGGGCACAGGGCAGATTTAGCCAATCTGCAGGCTGAGGGGGAGGGGCGAGGTCGGAGCCAAGGTCCCTGGGG


GAAGGGGCCGTTCCCAGCCTGTCCAGAGCCCAGAGGTGATCCAGGGCCAACCCTGGGGTCAGCCCACGGGTCACCAGGCCATAGGGC


TCCCCCACCTGCCTCCGTATCTCTGGGTACAGATCTCTCCCCTTGCCCCACCAGGGCTCTTTCTCCTAATGGCTCATTAATTATTCA


GGAACTGATTCTGGAGTGGGGTGGGACTGGTGTGGTCCCGCCCTTTGTCCTCAAGTGCTGGGTCCTGGGTGGAGCTAGAAGGGAAAG


GAGAAGGGGCAGGCATTCCCAAGGGGTGGGGCAAAGGGTCATGGGAGCACCAGGTACCAAAGAGAGGGCTGGGCAGGTGAGAGCAAG


GAAAAAAGACAGGTGGGGAATCACATGGGGAAGTGGGGCAGGGGATCTCCAGGCCTGGCTGGAACCTGCAGGGGCAGGTTGGAGTAG


AAAGCCTTATCAGGTGTGACCCACATGGTTGGCAGGAAGGTGAAGGCTTGTCCACGTGTGGTCAGTAGCTCTTGGACATTGAAGTAC


TGTCCTTGCCCTCCCCGCCGACCCAACCCCAGGCACTTTCAGGGCCTTCAGACAGGAGCTCTAGGGCAGGGGAAGGATGGCCCAGTT


GGGCTTCAACAGATAACACATCCTGGGAGAAGAGCTGCCCTCCTCCTCCTGCCTCAGACCCAACGCGCCCCAACCTGTACCCCTCAC


TCTCATCCCCCAGCCTGCTGTCTTCCCGTGTTCTCTCCCGTGAAAGGCATTACCACCCACCCGGTCACCCAAGTCAGAACCTGGGCC


TCCTCCAGCCTCCTCCCTCCGTGATATCCCACATCTAATCCATCACCAAGCTCCGTTGCTTCTACCTTCTGAATATCTTTGGAATGC


ATCCACTTCTCTCTCTACCGCCTTCATCCAAGCCACCCTCGGCTCTTGGGCTTTTGCACGCAACAGCCTCCTGACGGTTTCCCTGCC


TCCAGTCTTTTCCTTCCTAATCCATTCTGCATTCCAAAGGTAGAGTCGTGTCACAAGGTGAAAACATCATCCTGTCACTCTTCAGTT


TAGAATCCTTCATTCCCTCCCACCCCCAGGCCCCCAGGGTCGTAACCCTTCTATAGGCCCTGCATTATCAAGCTTCTATCAACCTCA


TCCCTCGCTGTCCCTCCACCCACCCCACTCACCCACCACGCTGACTTCTTTCAGTGGTTCACCAATTCCCAGTAGTAATTGGTAGGG


GCAAGGGGGAACAGTTTTTAAAGCAGAGAACCTCCATGCTGGTTCCTTAGGAACCAAAGCCCAAACACCAGGTCTTGACGGTAGAAA


GCAGCTGAAGAAGCTGAAATCCTGCCTTCTTCAGGTAGGGGGTTCAGGGGACTCAGGCCTTCTCCCAGGCAGAGAGCCATGGGGCAG


GAGCCTGGGCTGGGGGTCAGAGTGACCGAGCCGCAGGAGCCAGGGTCTGTCTTCCAGGCCTGTCTTACACTGCACACAGTTTTGGAT


CTCTCCCTGCACTGAGGCAGGGCTCAGGCTGAGCTTGGGCAACTACTAGCCAGGGGCAAGTGGCCATACACAGACAGGGCCACTGCA


GAAGATAGGGTAGGCACCCCAGAGAATTGACAGCTGGGGCAGTGAAGCGCGGAGTGGACAAATGTGTTTCAATAGGCCTCTTAACAA


GACAAATGAATGGGGGCCCTGGCCTCTGAGGGGAGTGGAGGGAAGCGGGTGGAGAAGCAGCTGCCAAGAGTTAGCCCAGAGGCCCCA


GTGTCAGTGCCGCACGCGCAGCTCCAGTGGAGATTTGGGCACACATTGGGGTAGGATCTGCTGCAGCGCAGCTTCCCCAGCCAGGCT


TTGTGGCTTCTCAGGAGGGGAGGTTGTGGGGCCAGAGGTGTCCTGAGCCAGGGCAGAGGTTTTTGCTGATCTCAAGTGCGTGTCGCG


TGCCTGTCTTCAGGCAAGACCTGCAGTGTGGAGGCACAGGCTTGTGAGCAGTGACCACAGGGTGTGCTGGGTAGGTGGCACTGACAC


AGGCCATGGCAGAAGCATCTTGGGAGAGGAGTTGGGAGGCTTCCTGGAAGAGGGGAGCCCTGAAGGGTGAGTGGACATTTGCTAATG


GGGGGGTATTGCATAATGAGGTGGGGTTGGGGGGAAGAAGCACGAATGTGGCTGGGCTTCTCTGTGGAATTCATGGGAGAGCCACAG


TGAGAACCCGACAGCATGGGACAGAGGTGGGGTCCGAAGACCAGGTGGGAGTGAGACCCTGGTTATGGCCCATTTACCCAGAATCCT


AGGAGCTCAGAGCAGGATGCGTGCTGGCTGGAGGGGTGGGTGGCGGGTGGGTTGACAGAGGTGGGCAGAGGCTGAGGAGCTGGGAGT


GTGTCTGTTGTGTCATTTCCCTCCTCCCCAGAGCCTGTGGAGCACACAGGGTCTGTTGTCTGTCGTCATGCTCTCCCCCTCGTTCTA


TGGGTGGCCTGTCTAGACTCTGCTCCCTGTGGGACTTCCCGCAGATTCCGTTGCTTTCTCTCTCTGGGCCTGTTTTCCTATTGCACA


ATGGGGATAATCACTCCTACCTGGAAAGGTTAACTGAGGTCACATGGATGAGGCGCCTGGAACCTAGTATGTATTCCCCTTATCTGA


GGCCATGACCTGGGGCTCTTGCTCTGTCCCTGGGAACCAGGCTTGTCTCTGAGTGGGCTCCAGGGGGGTACCAGGAACAGTCACAGG


AGCTCACTGAGTCCCAGCTTAAGCTGCTCAGACCCAGGGATATCTGTCTCTCCAGAAGCTCCCTGCCCTGCCTTCGCCGGCCCTCAT


GGCCCTGCCTCCGTGTGTACATGTGTATGTGTATTCCATGGGAAAGGCACAAAATAGCAGTCAGTCTCTCCATAGAAGAGCCTTGTT


GGTGGCCCAGTTTGACTCTCCCTGGGGCTGGACCCCTACAGCCTCCCTGGGAGGTGGTTGCAGCCCCCTTCCTCCAGCCAGTTCCAC


TTACTCCTTTCTTAGGCCACTTCCTCCCACCCTGCATGGGCTTGGTGGCTCGAGAATGTTGCCGTCCATACCCTGGGAGCTGTGCTG


AAAGGGCTGTGCGGCCCCCGACCACTGTGTGTGTCAGGGAGGGGGCACGCTCTCGTGGGGTGTCAGGCCAGGTGGCGGTGGGTAACT


GGCAGAAAGGCCCTCCTGGTGTGCTCTGGTGGCACCCTGTTGACCCAGTCTCAGAAGTTGTGTTCCGACCCTCACTGAACACCAGCT


GTGGGTCAGGCACGGGGCAGAGTAGTCCAAGTAGCTTGGTTTGCTGCCTGCCTGGGGACCTGACACTGTGGGATCTGGTCAGTGCTG


GGATGGCAAGCTCTGGGCACCTCAGGCCATGGGACACAGAGCAGGCTCCTACAGCAGCTTGGCTGGGTGGGACATGAGAGAGGGGCT


GGGCTGGGCACACTCAAAGGCAGGGAGGAGTCTGAGGGCCTGGCCTGTCAGGGTGGCCTAGGTGGTGGGTCCAAGCTGTGTGCTCTG


CACAGTGCTAGGCCTGTACTATAGTAGGTGCTCAAAAAATACTTGTTGAAAGAGTAAAGAAGCCGGGTGTGGTGGCTCATACCCGTA


ATCCCAACACTTTGGGAGGCCAAGGCAGGTGGATCGCCAGAGCTCAGGAGTTTGAGACCAGCCTGGCAATGTGGTGAAACCCTGTCT


TTACCAAAAATACAAAAAATTAGCCAGGCATGGTGGTGTGCACCTGTGGTCCCAGCTACTCGGGAGGCTGAGGTGGGAGGATTGCTT


GAGCCTAGGAGGTGGAGGCGGAGGTTACAGTGAGCTGAGATTGTGCCACTTGTACTCCAACCTGGGTGACAAAGTGAGACCCCCCTC


TCAAAAAAAAAAAAGACTAAAGAAAAGTGAGCCTGAGAGCTTAGGAGGAGCACATTTCAGAGGGGAACGGAGAGAGGAACATCAGGC


CCGTTGGTAGCTGAGGAGAGGTGCGGTTAGATCTGTGCTCCCCAAAGATCCTCTGCTGAACATAAGGGGCAACGCCTTGTCTCCTGT


GCTGTGTCCTGCGGGTGGAGGTGGATTGGAGGGAAGCGGAGGGCGAGGCCTGGTTGAGGGGCGGGGCCTGCCTGTCTGGTCCCCCGG


GCTGCCTTGGGCCAGCCTGGCCTAGTCTGTTGGGTGGGCGGGCAGGGTGCAGGCTCCTCTCCAGCCTCCAAGGGAGGGGAGTTGTTC


TGCCTCCTCGATAGCCCCAGGCCTTGGGCACAGCCCAGCCTCCCACGGCTCTTGGGCCCTCCTCCTTCCAGGCCGCCCGTGACCCAC


ACCTGGCTCTCCTCCCCGGCGTCTCCTCTCCGCTTCTTTGTTTGGAGCGGAGGCCCCGCCCCACCCCGCCCCCAGGCGCACTCGCCC


GGCCATTCCGGTTCAGCCGGTTCCAGCCCCCAGTTTCTGCCGCTGCAGGTCCCGGCAGGAGCTGGAGGGGCACTTTCTCCCTGGGTT


TCTCTTCCCTGGTGCAGCAGGGGCCGCGGTCCTCATCCTCCTGGTTCCTCAGTTCGGTCCTTCTTTCATTCTCCACCCCTGGGTGCC


AGGAACTGGGTCAGACACTGGGACAGGAATCCAGACAGGCATGCTATCTGCCCTGCCCAGGGTTATGTTCTAGGAGGGGAAGCAGCC


ATTAATCAAACACCAAAAATGTGGAAAAGTAATAATCTCACACGTGTGCATAATAAACTGTGAGTGAAAGTTATAAGCTCGGCAGGT


AGGTAATAAGCTAGGAGCAGTGCTGTGGGAGGCAAGGGAGTTACCCGGGAGTTTCAAACTAGGAACTGAGCTCATAGGTTGGGGGCA


GGGGGACTGGAGAAGGCAGTGATACTTAAATGGAGAGCAGAAGGATGAATGGAAGTTAGAGTGTATGGCGGAGGTTGGCAGAAGCAG


CAGCTTATGCAAAGGCCCTGTGGCTGCAGGGAACATGACGTTGCTCTTTAGAGGAGCCAAAGCTGGGGCTCTGGGGAGAGCAGCTGG


GTCAGACCCCGCGGCTTTGTCTGCCATAACAGGTGTTTTGAGAGTGATTCGGCAGGTCTTTGGAGGGTTTTGATAGGGCGGGGTGTC


GGGGGAGGCTGTCAGCTCACTCTGGACACTGAGTAGAGAACAGACGGGAGGCGTGGGGCAGGCCTGGAGGCAGGGGCTTCCGCGTGT


TAGGCCAGTGGAGTGCCAGTCAAGGGAAGGTGGTATCTGGACTAGGGTGTGGCAGCGCAGGTGGAGAACCCTGAGCTGCTTTGTGGA


GGGCTTCAAGTGTGGGGGAAGAGTGCACGGTATGGGGGTGGGGGACAGGAGACACCCCCAGTGGAGCCTGAGCAGGAGAGTCGTGTC


TGAGAGGGTCTGTCTGGAAGGCGCAACAGAGGCCAACTTTGCAGACAGCTGCAGTCGGGAGAGCCTGGAGCCTCCTTCAAAGGGCAT


TCAGGGGAAGGGCAAGGCACGCTGGGGGGTTCTGGACCTTCTGTGGTGTCTTCTTGTCTTTCTGGTCCCTACAGCCTCCCTGAGCTG


GCTGCCCGAGCCTGCCCTAGGCACTCTAAGAACATAGTCAGTCCCAAGGTCTCCCTCCAGGGAAGGCCGTAGGTGAGCTTAGGAGTG


AGAAGGCTGGATCAAAGCCTGGCTCCATGCCTGCATCCCTCTGACTTGCCAGTCATTTCACCCTCCGAGCCTCTATTTCCCCACCTC


TTAAATGGGGATAATAATACTACCTACCTTATGGGATTGCGGTAAGACTGATAATGCTGGTACGAGTGACAGCTTCCCTCATGGAAG


GCCCACCACGTAAAGCAGTTTACAGCCATCTCATTCCATCTATGACAGAATCCTGTGTCACTGTTTTGGAGATGGGAAAAAAGAGGC


TCAGAGATGGTGAGTGACTTGCATAATAATTACATAAAACCCCCAGAGCCCCTGGCCCCTGGAGTTCTCAAAAGTTCCTTCTCTGTT


GGTACCTGCAGCTGCCACTCCCTACCCCGCTCCCATAGACCCTCTCCTCCTTGGAGACTCTGCCCCATCTGCCGTCCCTTCTCTGCT


GGATCAACACCTTTTCCCTCTCTGCTGGCTCCCATCAGTATTTAAACATTGCCTTTCATATCTGTCTTCAAGAAAAAAAGAAAAAAA


AATTCACAAACCTCCCTTCCCGCCTCATCCTTTCCAGCTGCTGGCTGTATAGTCACCTGTACTTCCCTCTCTCCCTCATCGCCTCCC


AGTCATTCTTTGGCCTTCTTTGGTCTGGCTTTGGCCCCCACCCACCACTCCACTGACTCTGTTCTTGTCAAGGTCCCTGACAATCTT


GTGTGAACTGTTTTGTACCAGGTGTTTGACAGTCAAACATGCCTGAATTCAGGTCCCAGATGTGCCCCTCACTGGCATGTGATCTTG


GACAAGTGACTTGACCCCTCTGAGCCTGTAAACTGAGGATAATAGCAATGAAGGACTAAAGATAAAGAACCTGGTGCAGAGTGGGTG


CTTGGCAAAGGATTGTCATCATCGCACACGTTTCTGTGCCAGGGACCAGGCTGGGCCTGGGCTCCTGGGGACCAAACAGGTGGTCTG


AAAGGTCATTTCTCACAGCACTAGCCCTTTTTGGAGCTGTTCATTGGTCTGATTAATAGGAAATGGATCAGCTGTCAAGATTAACGA


GCTATTGCTACAAGATTGTAGCAAATGGGTTGGGCTTCTCTGGGTTCATGACCCTAGGTGGTTGAATTCTTAGGGATAGGGGCTGTG


GACTGGCCCTGGTATGTGTACTGAGGTGATGAGGGTGTGGCAGTGCCATGTCTGAGCCCCTACCTTTCTTCTCCTCCCTCTGCCTCC


CTGTGGACACCTTGAGGAGACTGTCAGAAGGCAATAACTAAGTCGGGGGGGAGGGATGGGAGAGGCAGATTTACAGGAAAGCATTCA


CCTGGGAAGATATCCAGAGAGACTTATGAACTGGACTGTCTAGGCCTTTGGGACTGCTGCTGGTATGTGGGGGCTGGGAGAGAGGGA


GGAGTCTCGGTTCCTGGCCGGAGCCCCGGGGTGGATGGTGGTGCCATCACTGAGATGGAGAGCAGGGGGAGGGACAACTCTCAGGGA


GAGCTGGAGCTCTTCCCAGCAGCTCTCCAGCACGCCTTTTTCCTGGAGCTTGGAATTGATGTGGGGCGGGCAACAGAAGGGTGCAGT


GGTAGTGTGAACTCCAGACTTGGAACACCTGGGTTCAGATCTTAGCTCTACCACTTACCACCTGTGTCATATGGGACAAATCCCTTA


ACCTCTCTGGGCCTCTAGAAACAGATACAGTTATAGCACTCACCTCATATGCTTAACAGAGTTAAAAAATGTTAAACTCTCTGAACA


GTGCCTGGCACATACTAAGCGCTACATAAAGGTGAGGTGTCCTTGTTTTCTTTGTAGGTCTTTCTCTCTGCCCCCATGACTGCCACC


TTCCTCACTGGCCATTCCTATAGTGACTGTGCTGTGGTGACTTGGTGTCTCCATCTCTTCCAGGCAAACCTGTCTTCATTAAAGTCC


CTGAGGACCAGACTGGGCTGTCAGGAGGGGTAGCCTCCTTCGTGTGCCAAGCTACAGGAGAACCCAAGCCGCGCATCACATGGATGA


AGAAGGGGAAGAAAGTCAGCTCCCAGCGCTTCGAGGTGCGTCTGTGGTGGGAAGGGGTCGGCAGGGCTCAGGGTCTGCCCACACTCT


CTCCTTTCAGTGTCCCTCCTCATGGACCTTTTGGAGGTGGGAGGACAACTGACCCTGAGCAGGCTCCTGTGTCCTGAGTAGGCTGTG


ACCCCATGTCTGTCCTCTGACAGGTCATTGAGTTTGATGATGGGGCAGGGTCAGTGCTTCGGATCCAGCCATTGCGGGTGCAGCGAG


ATGAAGCCATCTATGAGTGTACAGCTACTAACAGCCTGGGTGAGATCAACACTAGTGCCAAGCTCTCAGTGCTCGAAGGTACGTGCT


AGGGAGACGTGGCACGGTGGGCTGCCGGGCTGAGGCGTGGGAAGAGCCAGCCAGCCCTGATCCTGTCCTGGGCCCATGTGCATTTGG


CAGAAAGGAGGACTGGCCACCTTGGGGTCAGTGAAAGTCAGTGGTGGACAGGGATAGTCATTGGATCTGGCCTGGATTGTGCGGCTT


ATGCTGAGGCCAGCCATGTGGGGCATGATGCCTTTGTATTCTCCTGCTGAGCCGGGTCGTTGGTTGGGTGGGGTCTGGGGTCTGACT


TGAGGTGTGGAGCTGCAGCTGTGTATCCCTTGGGTTACGTGGTTATGGCTGTGCCTCTTTGGCAGTGAACCGGATTTCCATGTGGAG


CCTGGCCGTAGGTGTCAGGCAGGTGTGTTCCTTGTTGCCCCTGTGAGCTGAGGGCTGGGGCTCTGTCCGTGGATTTTAGTGTCTTCT


CTCACTTGGTGGCTTCTCCATTCATTCACAAACACTCCCTGGACCACCTTGAAGTCCTCTGAGCACCGAGGAGGAGGAAGCTGTGTC


TAAGCCAAGTCTTGAGGACAGGTGGGAGTTGGGGGTGGCAGTTGGCAGCTAGGCAGGTGCCCAGGCCCAGAAGCAAGAGAGGATGGA


GCTTTCAGAGAGCTCTGAGTAGTTCAATTTGGGTTTTCTGGAGGGCAGAGGGGGAGCTAGAGAGCACAGGAAGAAGGAGAAAGCAAT


TCAGCATGAGTCTGGAGAGGTTTGGAGGGCAGATTACACAGGATCTGGCTGAGAAATGAACACTCTCCTAGGGACATAGGAAGCCAC


AAACAAGGCGGGGGTGACATGATCAGACCCCAGCCACAACTGATTCATCAGTCTGAATGTGTTTATGTTTTCAAAATATAGCATCGA


TTGTTGCTTGCTTTTTTTTCTTTTCTTTCTTTCTTTCTTTTTTTTTTTTTGAGATGCAGTCTCACTCTTGTTGCCCAGGCTGGAGTG


CAATGGTGTGATCTCAGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCGATTCTCCTGCCCGGCCTCCCAAGTAGCTGGGATTACA


GGCATGCGCCACCATGCCTGGCTAATTTTGTATTATTAGTAGAGATGGAGTTTTACCATGTTGGTCAGGCTGGTCTCAAACTCCTGA


CCTCAGGTGATCCGCCTGCCTCAGCCTCCCAAACTGCTGGGATTACAGGTGTGAGCCACCGCACCCGGGCCGATTGTTGCTTTCTTT


TTAAGAATGTGATGTCGATACCTGTTCCTTTTTGAAAAATTGGAAAGTATAGAATAGCACAGAGGAAAAAATTAAAATGTCTCAGTT


TACCTCTAGTAATAACATTTGGTTACTTACTCGTGGCCCATTTTCTGTGCATACATATATATGTGTGTGTGTGAACAGAAATGGGAC


CACATACTGTCCGATGATTTGTAGACTGCTTTAAAAACAAACAAAAAAAAATATGGCTAACATCTTCCTTGCCACTAAATATTCTTC


TGTATCATTATTCTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTAGCTCTGTCACCCAGCCTGGAGTCCCGTGGTGCCATCTTGG


CTCACTGCAGCCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGGCTCAGCCTCCCGAGTAGCTGGGACTACAGGTGCGCACCACCACT


CGTGACTAATTTTTGTATTTTTAGTAAAGACGGGGTTTCACCATATTGAACAGGCTGGTCTGGAACTCCTGACCTCGTGATCCGCCC


ACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGTCCAGCCTGTATCATTATCCTTAATGGCTATGGGTAAGCTG


TCACATGCAAGTACCCTAATTTATTTAGCCATTCCCTTATTGTTGGACACATATGTTCTCAGTTTTTTCGTTTCTATAAATAAGGTG


CCATACACGTCGTTGCAGATGGATGTGTTCACCTTCCTGATTATTCCCTTATTCTAGGTTCATGGAACTGGAATTGCTGAGTCAAAG


GGCACATGCATTTTTAAGCCTTTTGATATTTCCAGAAGATTGTGTCAATTCATACTCCTGCCAAGCAGGGCAGAAGAGGGCCTCTTT


CCTGCACATCTTCCCCACTGTTGGGAAATATCTTCAAAAAAATATTTTTTGCCAAGTTAATAGGCAAAAAATGGCATCTCAATTTAA


TTTGCATTTCTTTGATTACAAGAACAGCTGCACATGTTTTCACATTGGCCATTTTTACGCTGTCGCTTTATCTGTTCACACACACAT


CTCCATTCAGTTACTCTTTTTGTTGTTGTTGTTGTTGTTTGGTTTTGGGGGGTTTTTTAGTTTTGTTTGAGACAGAGTCTCACTCTG


TTGCCAGGCTGGAGTGCAGTGGTGAGATCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGTGATTGTCCTGCCTCAGCCTCCC


AAGTAGCTGGGACTACTGGCAGGTGCCACCACGCCCAGCTAATGTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGG


CTGGTCTCGAACTCCTGACCTCGCCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCCTGAGGCACTGCGTCCAGTGTCGGTTAC


TGTTTTGCATCTGTGTCTTGTATGAGTCCGTGGGCTCTACAAGCTTAGAGGAGCCATAGAGGACAGTGGTTAAGACTCTGGACCACT


CACTTCTCGTGTGTCTTTGGGTTAGTAACTATGCCTCTGACCCTCATTTGCTCCATCTGTAAATGGATATAATGCCTACCACCCAAG


CTGGTTTGGAAGATTGAATGCTGTGTATGAAGCGCTTCCCAGGAGTGTGGTGGTGGTTGCTGTGGGGCTGGAAGCTGTACATCTTGA


GGCCTCACCACGTGAGCTGAAGGTGGTTGGCCTCCGTGCTGCGTGGCATCATCCGGGTGATGCAGCTCCACTGCCTGCTCCCACGGG


GGGACATACCTGTGCAATAGGAACTCAGAGAACAGGCCCTGGGCCAGCATCACTGATTGCTGAGTGTTCTCAGGCTCCTCCCTGCCA


CTTCTGACCTGTTTCCCCACTCGTGACCTGGGGGCAAGTATTTCAATGCTGCCCAGTCCTCCTATTGGCAGCTGTCCTAGCAGGGAG


CCATCTGCCCTGCCCTGGCATTTGGGAGGTGGCTGAAGGACCAGAGGCCCCAGAGGGCTTCTTTTCAGGCTCTCAGATTGGGGAACA


GGGCCTCCTTGTTAGTATTGAAAGAGGAGTCCTTCAAAAGCGCCTAAGCCCCAGGTCCTGGGTCAGGAGCCCTCTTACCTCTGCCAC


TGCCCTGGGCAGCCTTACCTTTCAAAGGGTTGAGGAGGATGGAGGTGGTCTTTCAGGCCTGGGGTGAGGAGGACGGACTTCAGACTG


ACAGGAGGGGCTGGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCAGAGGCCTGCACATCACTTGAGGTCAGGAGTT


CGAGACCAGCCTGGCCAACATGGCAAAACCCCATCTCTACCAAAAAATACAAAATTAACTGGGCGTGGTGGCGCACGCCTGTAGTCC


CAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGGAGGAGCTTGCAGTGAGCTGAGATTGCGCCACTGCACTCCA


GCCTGGGCGACCCAGGAGACTCCATCTCCCCCCCCCCCCCCGAGGACCTGCAGGAGGTGCCTCCGTTTGGTTTCTCTACCAGGGGCC


AGCAGTATATGTTTGCGCTTCTGGGGTGTGAGAAGTGTCTGATGAGGCTGGGGAGAGTGTGGCGCAAGTACCCAGACCCTGTCCATG


CTCCGGGGAAGGGTGTGGAGCTGTGGGCCTGAGTGAGCCCCTCCTGCTTCTGAAACATAGCACCAGGAAGACAAAATGCTGACTTAT


CCTGCTGGTCTGTATAACCTTGGCCAGCATTGGGCTTGACAGAAAGGCGTGCCGCAGGAGGGCCAGAGGGAAGCAACCCAGAGGGTG


AACACCCGCCCCCTGCCCCGCCTCACCCCACCCCTCCCCTCCCTCCTAGGAGGATCAAGAAAGCTGGGTGCCTGCAGGAACTGGGTG


AAAGGATGGTTGGACTTGGACTGGAGCTCTGGGGTGGGGCCGGCAGGAGCCAGGGCCATTCTTGGGAGGCCACCACAGGGTACGAGG


AGGGCTGGGGAGGGGATGGAGCTAGTTGGGGTCGGGGAAGTAAGAGTCCTTCCTGAGTTGCACACAGCTCTCCCTGTGAGCTGGTCT


CCTTGGAGAATGGCTGAGGGCTGTCTGGGGTGAACTGGCTCAGGTGAAGATCAGTGTGCCCCCAAAAAGGAGTCCAGGCCTGCAGTC


TGTTCTGTGCCCTCTGCCTTTGCCTCATGTCACACCAGGCCCAACTGCTGTGGCTCCAGGGCCACTCCCACCACAGCCCGTGGGAGT


GCCCCCCCAAATCCCCCACAGCCGTGCCCTTTGCACCTCGCATCTGAGCAGGATTGTTATTCCCAGTGTGGCCTCCCCTTGACACCC


CCGCCAGGACTGCATACGAGGTGGGGGTGCCCAGCACAAGCTGGCCGGGGTGAGCCTGTCCTGGCTGTGATGAGCGTGGGGCCCGCC


GCCCAGCGTTCCTGTCTGAGTGGTAATTGAAGCCATTAGCGCGCCAGCCTCTCCCTCGCCGGGTAATGGCAGGAAAAGCTCTTCTCG


CTCCGCACTCTTGAGGCGGCGGCTGAATCACTCCCCCTCCAACCCGCCCGCTGCCGCCACTGAGACAGGGAATCTGACATTTTCCCT


CACCAGGGAGGGGGAGCCCTGCGGGAGGGGAGGGAGGCAGGCCTGGATTCCTGGCCTTTCCCTCCAGGAGGTTGAGGGGCAGTGAAG


GTCTTGGAGCTCAGTCTGTAAGTCATGGATECACCTGGGGCCGCAGATTTCAGGCCTGGAAGGACTGGCCGGGAAAGCCCAGGAGGC


CGCCAGACATTCAGTGGTGTGGGGAGGGCACTGATGACTTTGGGTAGGTTCTGGGAGGGACAAGGAGGCGGGGAGAAGAAAGAAGCT


GTGGAGCAGAGATGAGCTGTTTTGGACTTCTCCTGGGGGGCTTAGCTCCAAGGGTTCTGAGTACAGGTAGCATTACTTGTCTTGGGG


TCATTGATAGGGCAGATAACGTGCACTGTTCGTGTGGTGTGGGTGCCCTGTGTGCCATGTTTAAGGCAGTGTTTGTGTGAAGTGTGT


GGTGCAGTGTGTGCAGCAGGGGTGCTGCCTTGCAAGCTGTGCGCACAGAACGGGGTGTGCAGCGGTCAGCGCACACGTTACCATCAG


GCAGTGGGGAAGGGGCAGTGTGTGCAGGAGGCACTGCATGCTGTATGGGCTGTGTATGCAGCGCGCAGTGTTTGTGTGCACGTGTGT


GCGTCAGGCAGTGCGTGGTGTGGTGGTAAGCAGGTAGTGAGTACCTTATGGGCTATGTATACAGCAAGGCATATGCATCAGGCAGTG


TGTGGGCAGTAGCCAGTGTGTGTGTGTGTTATCAGGCAGTATATGTGTGCGGTGTGCCGTGCGGCAGGCTACCTGTGTTTATATCGG


GTAGTGTGTGTGTGTTTATGTGCAGCAAGGGTGTGCAGTAGGTGTGCAGTAGACTGTGTGCAGCAGGCGTGTGTGTGTGTACAGCAG


GTGGTGTGCAGCAGGCAGTGTGTGTATGTATCAGGCGGGGTGTGGTGTGTGTTTATGTGCAGCATGCGGCGAGTACTTTGTGTGGTG


TACAGCAGGTGGTGTGCGGCAGGCTGTGTGTATGTATCAGGCTCTGTGTGTGTGTGTGTGTGTTTGTACAGCAGGTGGTGTGCAGCA


GGCAGTGTGTTTATCAGGCAGTGTGTGGTGTGTGTGTGCATCTTTATGTGCAGCGAGTAGTTTGTGGGGTGTGCAGCAGGTGGTGTG


TAGCAGGCTATGTATGTATCAGGCTGTGTGTGTGTGTGCGCGCGTGTGTACAGCAGGTGGTGTGTAGCAAGCTGTGTGTATGTGTCA


GGCAGTGTGTTTATGTGTGTGTGTCCAGCAGGTGGTGTGTAGCAGGCTGTGTATGTATCAGGCAGTGTGTGTGTGCGCAGCGGGTAG


TTTGCAGGGGTGTACAGCAAGCAGTGTGCATGGTATGTACAGCAGATGGTGTGCAGCAGGCAGTGTGTGTGTGTGTGTGTGTACAAT


AGGTGGCATGCAGTGGGCAGTGCATTTGTGTGCATGCAGCAGGCTGTGGTGTGTACAGCAGGTGGTGTGCAGCAGACTGTGTGTTTG


TATGCATCAGGCCGTGTGTGTGTGCAGCAGGCAGTGTGTGTGTGTGTACATGCGCACACGCAACACGCACTATATTTGTGCAGCAGG


CCATGTGTGTGGTGCATACAGCAGGTGGTGTGCAGCAGGCTGTGTGCTTGTACATGCAGCACATAGTGTATGTGTGTTGATGTCAGA


CAATGCATGTGCATGTGTGTGGAGTGTACAGCAGGTGATGTGCAGCAGGCTGTGTGTGTAGGTGTGCCTCGGGAGTGTGTGGGGGTG


GGAGTGGACAGCAGGTGGTGTGTGCCTTACAACCTGTGTGGGCAGCAGCAGGAGTGGGCAGCAAGCAGCCCGAGCTGAAGTGTGGTG


GGGTCAGTCTGGCACTGGCAGGAGGTCGGAGATGCTGTGTCTGGGCTCATTGTCTCTGGGACCCCGCAGGATCCCTGTTTGGAGCTG


TTGGTCCGCCAGGAAGTTCGACAGAGTTGGATGTGGCCAGAATGGTCTGGCTGAGCTGTTCTCAGCACCTGTTGTGGTCGACCTCAG


CAGCTCCTCTGTAGCCAGGCCAGGAGGTGGGGTGCACCAGATAGGGATCCTGCCCAGACCTGCCTGCAGGAGGTCTTGGGACCCTTT


CCTCTCCCTCCCCTACCCCACCAAGCCCACAGTCCCTTCTGTCTGTTCCCACCTGGCCTCAGTGTCCAGCCAGCACCATACCACCTA


TGCCATGCGGGCCAGGGAATCCAGGTGTCTCGATGGAGTGCCTGGTGTTGCCAGCCTTGGAGCAGGCTCTGGGGAAGGGCTGTCCGG


CACATGAAGTAGTGACCAGGGTGGGGGCTAATCAGTGCTGTACTGGGCTTGGACCTCTGGGTTCTGCAGGAGCTCTGACCCTGGCTG


GCTTTGGGGCTCGTGGGATGACGAAGGACCTCTTGATATACCCCCTGACCACTCCACAACACAGTCCTTTTGGAAATAGCCCTAGAG


ACAGAGGGTCAATGATAGACATATGACCCTGTCCTGAGGTATCCTGGGCTGGGCTGGAACTGGAGCAGAGCTGGTGAGGGAGCTTAC


ATTTGCAAGATGGGTACATGTGTGTTTTCTCAAGGAGTCATCTCTCCCTGCTCCACCTCCTTCCCTGCTCCAAACCTGTATATTCCT


TCCACCCATGGTGGAATGACTTGGCCCAGGCCTGACTTTGATGGCTGGGGAGTTGGGTAAAGGGCTATTGCAGGCACAAGATGGCTT


CCCAAGTGGCAAGATGTGATCCCTTTCTATTGTCTACATGTGTGTCTGGGGTAACAGTCTGCTTTGGCAGAAGCTGGGGCTGTCAAC


TACCTGATTTGCAGCAAGAGGATGTAGAAGTGGCCCCAGAACCTGGAACCCAAGCCAGCTTCTACCTCTCCCTTAGCAAACTGAGGC


ATGACCTGTATACCCCTGGTCCAGCTGCTGTAGTCCTCTGTGACCTGTCCTTACACCCCCATGACTGCAGTAGATTTCAGATCCACG


CAGACATGAGGTTCTACAATCATTTCCTGGAGGTTCTAGGCCTCAGGGATGGGGATGGGAGAGGTATTAAGTAAGTTCTCCTGTTTT


TATTAGCTGTGATCTGCCTTGAGGCGCCCAAGTGGATTCCCTTCCGAATGGGTGCTCCTGTTTAGTAGGTGGTACTCCTGCCTCTTC


TGTTAGCCATGGACACTGGGCACTTCCCCTGTGCCCAGCCTGCCCCCCTGCCCCTATACTCACAGGTACTTGTAAGGCCCACTGTAC


GTGTTCCCTAGCCTCATGACCACGGTGGAGCCAATGGCTCTGGGAACAGGCTCACCAGGATGGCGGTTTAAATGCCCAAATGCCCTG


TGCATGCACATTCTCCATCCTTGGTAAGGTGCTCCCTCCTACTGGTTTGCTTGCTGGGGAGAGAGCACTTGTTTTTTTTTTTGAGAT


GGTGTCTGACTCTGTGGCCCAGACTGGAGTGCGGTGGCACAATCTCACCTCACTGCAACTTCCGCCTCCCGGGTTCAGATGATTCTC


CTGCCTCAGCCTTCCGAGCAGCTGGGACTACAGGCACGCGCCACCACACCTGACTAATTTTTTGTATTTTTAGTAGAGATGGGGTTT


CACCGTGTTAGCCAGGATGGTCTTGACCTCCTGACCTCATGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTATAGGCGTGAG


CCACCGCGCCTGGCCCTGAGAGGACTTTTTTGAAACGGAGTCTCACTCTGCCACCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTC


ACTGCAACCTCTGCCTCCTGGGTTGAAGCAATTCTCATGTCTCAGCCTCCCGAATAGCTTGGGATTACAGGCATGGACCACCACGCC


CGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACGAAACATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATT


TGCCCGTTTTGGCCTCCCAGAGTGCTGGGATTACAGGCATGAGCCACTGCTCCTGGCCAAATTTTAATCAGAGCAATGACGTGATCA


AACTTAAGCTTCAGAAAGGTCCGTGTGGGTGCATAGTGGGGGCTGGAAGGAAACCAATGACAGGTTGTTGCAGTCCAGGTGAGTGAT


GGCATTGGCGCAAATCTGGGTATGGGTAGGGGAAGATAGGGGAGCAGATCACTAGAAGGTTAGAAAGAGGCCGGGCACGGTGGATCA


TGCCTATAATCCCAGCGCTTTGGGAGGCCAAGGTGGGCAGATCACTTGAGGTCGGGAGTTCGAGACCAGCCTGGCCAACATAGTGAA


ACCCCGTCTCTACTAAAACTGTAAAAATTAGCTGGGTGTGGTGGCAGGAGCCTGTAATCCCAGCTACTCTGGAGGCTGAGGCATAAG


AATTGCTTGAACCCGGGAGGCAGAGGTTGCAGTGATATGAGATGGCGCCACTGCACTTCAGCCTAGGCGACCAAGCGAGACTCCATC


TCAAAAAAAAAAAAAAAAATAAGATTAGAAAGAGTAGAGGCCTGCCTGGCTACCTGTAGGATTGGGGAGGTGCAAGCCTCCAGGTTC


CTGGCTCTGGGGCTGGGTAGGTGGGGGTGCCATTTCTAAGATTCATGTACTAGACGAGGACCAGGTTTGAGGAGGCGAGTTGGTGAG


TCCAGTTAGAAATCTGTTGAGCCAGGTGTGCGCAGGCATCCAGGGAGGTGTCAAAGAGGCCTCGTACACATTTGCCTGGCACTCCGG


GGGACATCTGAAGTTGGAATCTTACAGGCTGAGAAATAGCAAATCTCAGGAGGCCAGAGCCAGGACAGAAGGAGCCCCAGGAACCGA


CTCTCCATGTTGGGAGGAGGTTCCTGAGAGACTGGAGGGAAACTGGGAGTGTGTGAGGTCAAGAAATGCCAAGAGAAAAAAGTGTGC


GAAGGACGAGGAGTGGTCAGCAGGGCGGGGTGCTGCCGAGAGGCCCGGCATGTGTCCTTAACAGTTAGTTCCGTGGAGCCATTGTTG


GCTTTGGTGTTGGGAGACAGCAGGGCTGAGAAGTGAGAGGGAGGCTATCAGTGTCTGTAGTGACTGGAAGGGCCCGAACCTAGGGAG


TGAATGGATGACAAGAGTCTCCCTGGAGTAGGACTGAGGTTGGGGAGCCACTGAAGGAGAGTCCAGTGTGGGCCCGAGTCTGGAACT


CCAGTGTGGGTCGGGTGTATGCGCAGGGCATGGCCCCTGGGTTCTTGTGGTGGGGAGGCCTCAACTGGGTTGAGTAGGGCGATGTCG


GGTGCCAGGGAAACCCGAGGAAGGAGGGGATGACTGGGAGCGGGACGCCGTGCCTGCCAACAGGCCCCAAACAGCTCAGATTGAAAA


ACAAAACAGGCTTTTAAGATGCCAAGTTTGATGAAATCTGAGTGCTGGAAGAGGTGGGAGTTTGCTCTTGGAAAAACAGCTGAAAAT


CGAGACTCAAAGCTGCGAAGGGAGATGGGCCCAAGGCTCCCCAGGCCCCCCTTACTGCCTGGAAGCCTGGGGGTGGGGCTGGGCTCT


CTGGGAGAGTGTGGGAGCGTGCAGATCTGGCAGCCTTCGACTTTTGGAAGGCGTCTGGCTCTGGCCCTGCTGAGGATGGAGCTGCTG


GAGGTGGCCTTGGCTTCTGTGGAGCGGCTGAAGGGCAGGGGGAGCCAGCAGCCCTGCCACCTACGAGGTTCCTTCATGTGTCTCGTC


CCTGCATGTGTCTCCAGGCGCACGTGTTTTGGCATAGGTGTGTCTGGGTGTGCATGTCTCCACATGTGTGTTTGCGTGTCTCTGTGT


GCACCGCCTCTGGATCTGCTTGCATGCGCCTGTTTCCACAGGTGCTAGTCACTGCAGGTGCCCCTCCACATGCACATGTAGGTTTCT


ATTTTTACACCTGTCTGTTTCTCCATGTATATTTCTGTGGGTTCCTGGCTGTGCATGTTTCTATGGTGTCTGTGTGTTGAGAGGCAG


GGTGAGGCCAGGCCCAACACTCAAGCTTAGGGGAGGCGGTCAGGCTCACAGACGGTGCCACCCCAGGGGGCCTGTGTCTGTGTGTGC


GGGTGCGTGCCTGCGTTTGCACGGAGACGCCACGAAGCTGGGTAAACATGGGTGAAAAGGTCATACTGACAGACGGTGCTGCCTGCC


CCAGGACCCTGCAAGGCGTCTCCATCTGTCAGCTTCCCTGGTGCAGCCCCCTCCCTCTGGCCCAGAGACTCACCCTCAGGCGTCCAA


GGCTGAGCTGGACAAAGAGACCTGTGTGTACTTTGTAGGGGGCCTCAGCAGCCTCCACCCCCATCTTAGGCTCCTCTGTCAGGACCC


CAACACATGCCCCAGCTCCCACCAGACTCGCCTTGGTACTGTCATCCCACCACCTTCCCCCACAACAGCCTTTACAAAGGCAGTTTT


CCCCTCCTCCCTGGAAAGCTTTCTGCCTCCCATGCTCATGTGTTTCCTGTTCTTGAATCTCCCTCCTCCAGGAAGCCACCAAGATAG


CAAGTGAGCTGTGGAGTCAAACCGATCAGCTCCAACACTGCTGTGGGAGGTTAGCCAAGCGCTCATCCACTTCTGAACCTTGGATTC


CCACCATCGACCCCCGACCCTCCCCTCGCTAGGGCTTGTCATCGTCTTCTGCCCATGGGGCAACCAAACCTCTCCACGGAAGGGGAC


AGGTCTCCTTGCTGCAGTGGGTAAAGGCCAGCGCAGTTAGGTGCAGGAGGCATTCACACACACGTGCACACTCCCCACCTTGCACAC


ATATCTGCGTGAGCCGGGGAGACCCTAGGGAATGTGTGTGCATGTTCTCTATGCATGCGGGTAGAATCCGCAAACGGTGTGGAGACT


CGGGCTCTTGGGTACCTCTGAAGGCCCCTGAAGTCCCCATGGGCTTCTCCTTCCGTCCAGGGCACCCTCTTATCAGGCCATGGCCCT


GAGACGCGTAGTGCAGACGCCCCCGGCGCTGAGGCTGAGGAGGCAGATGGCCCCTCCCCGCACTGTGCAGGGCACCCGGTTGGGGGT


GGAGGGGAGGGCCGCGTCGGTGAAGCGGGAAAGCCTAGTGGGAGGATTCCCTGGAGCTGAGGAGCCGGGGCCTGGGAAGGGGCGCAG


AGGCTCCACCCAGGCGGGGGCGGGAAGGGCGGTGCCAGGGCGGACAGCGGACGCGCGCGCCTGCACGGACTCGGGCACACGCAGCCC


TTCCGCGGCAGCGCCCGCCGCTCCACCGTCGCCATGGCTACCGGCTGGCCTGGAGCGGGGAGGGGCCCTTCCTCCCCTTCGGCGCCA


ACAGCAGGCGATTTGAGGGGACTCAGTGTGACTGGTGCATCCCGGGGTTGGAAAATGGGTGGGTGCTTGCGACTGTCCACGTGTGGG


GGACCCTGGGGTTCGCTTTGCGGTAGATGCAAACGCCGCGGCGCGTGTGCGCGGCTCTGCAGTGGAGCCTGAGCCGTGCCGGCCGAG


GCGTGGTGTGGGGGAGGCTGCCGGCCCTCTCGCGCGCGGGGTGTTCACGCCTAGAGCGCTGGGGCTGGGGGCCTACCACCCGGTCTC


CTCCCAGCCCCACCTCCGATTTAGCTGTGTGACCTTGGGCAGGTGTCCAGATGTCTAGATCTCTCTCAGCCCCTGGTTGCCCATGTA


CCTCATAAGGGTTTGGTAAAGATTTAAGTCATTTTGTAAAGCATTTTAACATAGTACCTGGAACCTAGTAAATGCTTCATAAATCTT


ACTGTCCCTCATACCTGGGTCTCAGTTTTCCCAGTTGTTGATGGGTTTGGAGTGATCATGTGACATCATCTGAGGAGTTGCCCAGGT


CCTCAGCCTGAGTGTTGAGGCTGCGGTAGACCCAGCTTCCGCGGGTGCCCGTGGGGGAAGGTGGTAAGTGTGCCAGTCTGGCTGATA


GATCAGTTTACACCAGGATGCCCAGTGCTCAGCCAGGCCAGGCGCATGGTGGGCGTCAGGAAAGGGCTGCTGTACTTGGCTGAGTTG


AATGTTCAGAGGCGCCTGCATGGGAGAGAAGGAAGAGGCAGCAGCAAGTCGCTCCTGAGGGGCTGGAGCCCTCCTGTAAGACCCACT


TCCCTTCCCGGGTGGCAGAGTGGCAGACTTCCGAGTGCTGCCTAGAAGCCTAGTTGGCACAGGGGACTGGCTTTTGGGTCCCGCTGT


TTTATGGACAGCTCTCCACACATTCTGGTTTTAGGCTCTGGCGGCAGTGCCTGAGGGATGATCTGAGCCAAGGACAGAGCCACTGAG


GGCGTGATAATTGAGGGAGGAAAATTAATTGTCCTTAATTTGGCGTAAATCCCAAAGACCTTCCTCGTGTAAGGAATTCAGAGTAGA


TTCCGAGACACAGGGCTGCACACATTTGTACTTCCCTTCCCTTCCCTATCTGCGGGTGGAGATGAAGGCCACTTGACTCCTGGGCCC


TGACTCTGGCAGGCCATGGCCACGTCTTCCCCATGAGCTGGGCAGGTAGGAATGAGGTCTTGAAAGAGTTAGACTGGTGCTCTGGAG


GGCACCCAGGATGGCCCTAGCAGCCCCGAGTGTCCCCAGGTGTTGGGGAGGTGAGCCCTGCACCTCTGGTCCCCCTCAGGCCTTCCT


ATGGAAGCAAGCAGCAGCTGGGCCAAAGGAGGCTGATCCCCTGCCTGGTGCATCTCAGTCCTCTTCATTTCCGTCCTCCTTCCCTTC


TCTTGCCACTGTTGAACATTTTACTTTTAAAAATCTGAAAGGGCACTGTGGGATCATATTTACAGCCAAGGAGACACTGGGTTTATA


TCCAGAACTTCTAGGGCTGCAGGTGGGGAAACGTACAGCCAGGTCCCAGGAAAGGCTGGGGCGGCAAGGCCGTGCTGGGAATCCTAT


TGCTCTCTAGCCTGAGACCTCTGCTCCTCATGGGCCACAGTCCCTTTGGGATGTCCCTGGCAGCTAGAGCCTTGGGGAGCATCCCCT


GCGACTGGCAGCAGATAGATAGGTATCTTGCTCCTGCCTGTTGGGGCTCGTCCAACTCCCTCTTCTACCCGCCCCCCAGTCGCTCTC


CCTGGGTCTCCAAGAGGCTCCAGGGACGGCTAGTTTCTGCCAGCCTTTACCTTCTTCATGTCTGAGGATGCCATGTGCCTTTACTCT


GGCATAGAAGCCTGACTTCCCTTGGCACATGTTCCCATACACCCATCTTGTGCTGGGCTTGTGGAAAGGAGGTAGAGTGGTGCTGGT


CTCCCCCACCATGAGCCCAGCTCCCCGCCTTCCCCAGGAGACAGACAAAGAACACACATTCCCCTTGCCCCACATTGGGTGTGTCTG


GCATCCACACTGGGAGAGACACTCTGCTGAGGCCTTGAAAATTGGTGGTTTGCGATGGGGCCTGGTGGCTCACAGCTGTAATCCCAG


CACTTTGGGAGGCCGAGGCGGGTAGATCACCAGAGGTCAGAAGTTCGAGCCCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTA


AAAATACAAAATTTGCCGGGCGTGGTGGTGGGCGCTTGTAATCCCAGCTACTCGGGAGGCTGAGACAGGAGAATTGCTTGAACCCAG


GAGGCGGAGGTTGCGGTGAGCTGAGATCGCACCACTGCACTCCAGCCTGGGCAGCAGAGTGAGACTCCATCTCAAAAAAAAAAAAAA


AGAAAAAGAAAATTGGTGGTTTGGTCCTAGTGGGAAGGGCCTCTCACCAGCCTAGAGTGGAAAAGGGAGTTCCCGACTCTAGTCTCA


ATACCTGTCTGCCCCAGTGGCTCAGCCCTTACTAGTTACACCAGCTAATATTCACTGGGAGTGAATTCCGCATCAGATGCTCCGCAA


CACCTTGCATGCATGATCAGATACAGACCTCACAGTAGCCTTACCATCAAGGTGGGCACTTGAACCCTGTGTACAGATAAAGGAGAC


AAAGAATGAGTAACATGCCAGGCCCTAAAGCTAGTTCGTGGTGAACGTGGGAGTCCCATTTGATCTATACTAGTCCTGAGCCTGTCC


TGGACTTGTGCTTCCAAGGGGTGGAGAGTAGATAGCCTTGCCCTGCAGCCCCTCGGGGCTGATATGGGAGCCCATGTACAGTGGGAG


TGGGTTTGCTGCTGACATCTGTTCCTCTTACTCTATGCTAGTGACTCCTCTGTGTGCCGCCAAACCCCTAGCAAGCTGGGAGGGGCA


GCCAGGAGGGAGTTTTTTCTCCCCCTACCAACTTTTTGTGTCTTTAGAGCTTTTTTATCTCCTTTGCCTCCACACACTCAGGCATGG


TCTGCAGCCCTGACCGTGACTCCCAGGGTCAGGACTAAGTGAGGGAGAAAGCTCAAGGTCAAGGCTGCAGTAACGAATAGGTCAAGG


TCAGGATCGGAGTTAGAAGGGGATCATTGGTAGGGCTGGGGGTGCCCCGGGTCAGGGCTAGAGACCAGGCGGTGACCTGGGGCTCTG


CCATGTGATAGAGCTGAAGGCTGGATGAAGGGAACACTGTGTGTGCGGACAGGGGAGAGGGGGCTGGACAGCACAGAGGCCTTCAGG


CTGAGCTGTGGCTGTTGGATGCTGCGCGAGCTCCCTGCTAGCCCCCCCCCCCACCCCCTGCAGCCCCAGCATTCATGCAGTGCTTTC


TGCTGTGACCAGCAGAGCATTGATTCTCGTTCTTCTCAGGGCCTGGAGAGATAAGTGCTGACGCCTTCAGTCTGAGGCGTTGCCTCT


CAGACCTGGAAACTCCCTGACAGGGCAGGGGTGGGCCCCACTGCAGCCTCTGCCCTGCCAAAGAGACTTGGGACCCTGGTTCCTCAA


ATCGGGGTATGCTTCATGCTTAGAAGTCAAGGAAAGGGGAGGGGAGTCTTGAGGGCCCTGGCCAACCTGCAGTTGGGGAGGTTACCC


CCAGAGGGGTCATAGGGGGCAGGCAGAGCCAGCCCTAATACACACATTGCTGTTTGTCTGCAGAGGAACAGCTGCCCCCTGGGTTCC


CTTCCATCGACATGGGGCCTCAGCTGAAGGTGGTGGAGAAGGCACGCACAGCCACCATGCTATGTGCCGCAGGCGGAAATCCAGACC


CTGAGATTTCTTGGTTCAAGGACTTCCTTCCTGTAGACCCTGCCACGAGCAACGGCCGCATCAAGCAGCTGCGTTCAGGTGAGCAGA


GGGCAGGGGTCAAGGGGCCATGCAGACCTCAGAACAAGCGTCTTGTCAGATCCCAGCACAGCCTACTCCCTTGGGCCTGGGCACCTC


CAGGGCTGAGCGGAGGGTACCTGGTGGGGTGGGCTGGGTCTTACTGCAGGTGTGCCTGGCTCAGGGAAGAGAGCTCGTGGTTGGCTG


TGCCGTTACCTTCTTCGGATTGTCAGACTCCAGACTTTGGGCCAGTTCTGCCCCTCCCAGCACATGTGATGTGCCAGTGTGGTGGAC


TCTTCAAGGGTGCTCTATGGATGTTCACCCTCCTCCTTCCCTGTAGCCTGGCCTGAGACAGGGCCTGGATGATGCTTCTCTTTGCTT


CCTCAGATGGCAGGGCTTAGCTGGGAAAAGAGGCTAAAGGTGCCTGATTCATCAGGCTTCAAAAGGCTGGATCTCAGGGGCCTGGAA


CTAAGGGGACTTGCTGTTGTCCCTCGACCACCAGAGCCACCTGTCTCCTCTGGATGTCTCCGTCGAGCCAGCTCGGAGCCCTGGGAG


CAAGGATGCCATCGTGCAGGAGGGAGGTGTCACCCCATTGATCGATCTGCCTGTGAGGCTCCTGCCAGGATAATTGATTCAGTTTTT


GTGGGAACAGAGCAGGCGGGAAAAGAGGCTCAGAATCAGCTTGGCTGCATTCTGCATCTGCTGCCAGCACGGCCTGGACCAATAGTC


TTTGCTTCAGAAGCCCTCCTGCTAGCTATGGGATGGTTGGCCTCGGGCAGGATGGCCAGTGCCGGCCAGAGCCCCTTCTGCCTGTCA


GTTGTGATGTCAATGATGAAAAGGAGGACATGACTCTTGCCCCTTTCAGGGGCCTGCAGGCTTCAGAGGTGCCCTCCCACTCCCTGG


GATGCCAGCCCCTCCCCATCAATTCCCACCAGCCTCACAGCCCCTTGGTGCCCAGCAGGAGGAGGGAGAGACAAGCTGCCCAGCAGG


GCAAGATTCTGGCCCCAGCCACGGCCGCCTGAGACAGCCCACGAAGTGTTAGCTCATTTAATTTAATTAAAACTCAACAAGATGGAG


GCAGCTGTAGCGCAGTTAATTAAAACAGCCATAATCAAGGCAGCAAACGGCCGGCAGTGTTTGTGGCCGCTGCCCAGCGCAGCACAG


CGGCCAGCACGGTTCGGCTCCTCTGCATTTTCTCATAGTTCCTCCAGCCAGGCTCCCCAAGCAGCCAGACGCTCCTCCCTGCTGGCC


TGGGCCCCTCCACAGAACCACATGGACTTGTCTGGCAGCAGCTCTGGGAAGGCTCGCTCACACATTGGTTCATCTAGTATTTATATA


GTGCTTGGGGTGCCCGGCCCTGGGCCACCCCTTCCTTGCCTATCACTCCACTGGATGCCACTCAGGCCCCATCCTCCTTGTCCTCTC


GGCAGCAGCTAACATTCCTCCCTCCTTCCCAACCACACTCCCATTTTTCCCTAGCCTTTCAGGGCTCTGTCTCTTGCGACTTCCCTC


TTCCTAGTGCCCCTTCCCTGCAGCAGCATCTTCCCTTCCACCAAGCCCTGCCTTTGCCCTATGGACACAGCCTTGCCCTGGACGAGC


TCACCCCCTCCTAAAGCTCCAACTGCCATCTCCTCACCTGCAACTCTAGCTTTAGTCTTTCCAGCCCAAACCTCTTACCTGAGCTCT


AGATCCAAAATTCGACCTGCCTTCTGGTCACCCTGACCAGTGGTGATCAGTGATGAGTGATGACCTTCTTTTCAGACAGCTGTACCC


TCTTTCCATAAGTGGCACCCTCCAACCTGGAACATGGGTCTCAAGTTGGTTTGAGAGCTCTCAAATGTACCACCCTCGTGGCTCTAA


AATTGGCCCCCTTCTCCCCTCCTGCTGCGTCAGTCCTATCCCAGGCACCAGACACTGCTTTCCCTGCCTCCGGGCCCTCCCGAGAAT


CCATCATCCTGTAGGTCAGGTTTGCTGCTCATACCTTCCTGTGCCTCAGTGGTGTCTCCTTGCCTACCTGGTCAAGTGACGCTCCCA


AGCAAGGCTTAGAGGGCCCTTCTTGGTCTTCCCCTGCCCGTGTCTCATCGGGTCCTGGCTACACCACTTACCAGCTCTCTGGCATTG


GTTAACTTTTTCGTGTGTCAGTTTTCTCATGTTTGAAAGGAGTTACAGTAAGCAGTGAGTGAGTCAATGGCAGTCCCCCCCTTGAGT


TGATGGCCTGGCCTCTGGTAAGGGCTTCATGGAGCTCTTTCTACTTTCTGTACCCTTGACCCTCCTAACACTGAGCTGTGCTGACCC


GTCCTTGGTCCTTGCCCACCTCCGGCCCTCTGCTCACCTTCCGGCTGCTCCACTTGAAAACCTCCACCCTGCTCAGCCTCTGGCTGC


TGCCTCAGGCCTCACCTTGCTTTACATTGTCACCATCTGGCTCCAGTTCTGCTCAGCTAGGCCTTGCAGGGAGGGCCTGGGTCTGAT


CACACTTGGTGAGGTCAGCTGTAGGACAGGTCTTCTCTGAGCCCTTGTCAAGTGAATGATTTCATGAACTTGACCTTTGGCACTTGT


CCCTGTAGGCTAATATCTGCTCTAATGTTCACTCCTCCTTCTGCTTTCCAGGTCCAAGGAAGACTTCCTTATTTGTCTTCCTGCCAC


CTGGAAGTTGTGACCTCAGGGTCGTGGGCCCAGGGTCCAGCTCCTGGGATGGAGCCAGATGGCACCTAAGGGGCCTCAACCATCCCA


CCTCTGCAGTAATAACTGGGCTCTCTCCCCTCCCTGCCTGACCTGGCCTGGGACCGTTGGCCTCAGTTGTTGCTGGCCTTATCCCAT


TACCATTTAGAAGGGTGCTAAGGCTATTCCGTGCACATTTTTCAGGGACAGCCCTTCATGGAGTGGACTCAGGCCCCTGAGCACTCA


GCTGTTTACCGGGACCTTTACGGTTTACGCATCACCGACAGTTTACAACAGAGCTTTCCCCGCTTTTGTTGCAGCTGATTCTCTTGC


AGCCCTGTGAAGTAGGACAGGCTGTGATTACCATGCCCCCTTCACAGCTGAGTTAAGGGAGTCACTTGGGGTCACACATCGAGACTC


GGCCTAGGAGCTCCCCTGTGAGATCACCTCAGGACCTAGTATCACAATAGCAAACCTGGGGACCTGAGGAGCAGCTGGACCCTTCTG


GGGCTTCAGAGCTGCACATTCCCAGCTTCTCCAGACCCCAGGCCCCCACTGACCAGTACCCAGAAGTCCTCCACCATCTGCAACCTG


AGCCACAGCACATCTAACCAGGGCATGACCCCCCAAGTAGGAGCTGGACAGGAGGTAGCTGACGGCATGCGCTGCCCAGATGTGAGC


TCTGCTCAGCAGGCCTTTTCTTCTCTGTAGTGATGTGACATGCTGCCAAAACCACCTCCTGGAGAATTGGAACTTGAGACCGGGGTA


GGCCCAGGAGGAACAGGAACAAGCTTATAGAGTGGAAATGGAGTTGTGAGCAGGGGCTCAGAGCCCCTGCTGGGTCCTGAGAGGAGC


TGTTGGCCTGCAGGCTGTGCCGAGCCTGGACAGGGCTTGAGGAGATTCCCGCACTCCTGCTGTGGCCTGAACATATGAGCTGCCATC


CTTTGTCGTAGAGGACAGCCTAACTCACTAAGTCCATGTGCTCATCCAGAGAGCAGTCTCTTCCCCACCCCCAGCACCCTGAGGCGA


AACCTGGGGGTCTTAAGAAGAGATGCAGCATCTGGCTGCAGGAGGAGGCCCGTGGGTGGGACGCAGAGGGCTTGCAGCCCCTCACCC


TGCTGGCTGGCCCCAGCTCTGGCTGGAAGAGCCTGTCCCCACCCCACTCTGCTCTGCCATCTGCGGGGCCTGCCAGGAAGGCACACT


GCCAGTGCATGCTCACAATTTCCCTTTGGCCCAGAGCTCCCTGGCACCTCTTGGACACGAATACACCCCTAAGGATGCTGACTTCTG


GGCCCCTTCAGTCCCCCACACCCATCTTGTGAAATGGAAAAGTCAGATTCTCTGTTTGGTGGGGAAATTACTGTTAGATTCTTTCAG


AATAGGTTAGGTTCTGGAAGAGCTGAGGCCAGGAGCGAGGGATGCCAGCCCTGGACCATATCCACTGCTCCCACCCCCACCAAGTCC


TGGCGTGGATGACAGGAGATCAGCAATGTCAACTTTTTGGTCTCAGGACCTCTACTTGTAAATATCAGAGAACCTCAAAGAGGGTTT


GCTTGTGTGGGTTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTTTCGCTCTTGGTACCTAGGCTGGAGTG


CAATGGCGCGATCTCGGCTCATCGCAACCTCTGCCTCCCAGGTTCAAGCAATTCTCCTCCCTCATACTCCTGAGTAGCTGGGATTAC


AAGCATGAGTCACCACGCCTGGGTAATTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGTCAGACTGGTCTTGAACTCCGA


ACCTCGGGTGATCCGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGGGTGAGCCACCGTGCCCAGCCATTGTGTGGGTTATTT


CTATTGATGTTTACCATATTAGATATTAAGACTGAGATTATTTTAAAATATTTATTAATGCATTTTAAAATAATAAAAACCTATTAT


ATATTAGCATAAATAACATTTTTAAGGAAAAATAGTTATTTTTTTAAAACAAAAATATTTACCAAGAGGGACAACATTGGTTTACCC


TTATTACAAATCTCTTTAATTTGGGACTTATATAGAAGGCACCTGGATTTTCTAGCTACTTTTGCATTAGGGCAATTGTGATAGCAC


ATGTCATGTAGCCTCTGAAAAACTCTACGTTCATGAGAGAAAGTGTATAAAGCAAATAATTTCTTAGTATTATGAAAACAGTTTTGA


CCTTGCAGACCTCCTTATGGACCTCCTGAAAGGGTCTCTTGGAGAGAGAGAATCATTGTGCGGATTCTTCCCACATAACCCTCACTC


CCAGGTCCCAGCCTTTGCCCTCTCCCCTGCCTCTGCATCTGCAGGACTGGCAGCCTCATCCTGTGGGCAGGCTATGAGTTAGATGGA


CCTTGTCAAGTCCTTCCACTTCACTCACAAGCTGGTGTGACCTTGGGCTTTGAGTAATTCCCTGAATGTCTCTTGGCCTCTGTTTTC


TCATTTGAACTTAGAGATGAAGAATTCCTCTAGGTGCTGTTGTCAAGTTCCATGAAACGGATTGGTGTTGATTTTTCTGCACACTTC


CCAATCCCCAGACGTGGGCAGGAAGCAGGCAGCAGGGCAGGGTAGACGTGGGCTGGACCTGGGCCCATCTGTGGGCTCCTCACTCCT


CTGGGGAAGGCAGTGGTTGCACAGGGGGCTTGAGCCTCAGAGAAGGTACCTGTTGGGGATGAAACCCGCTCAAATCTCCTAATAGGC


CTGGATATGGAGGGTGAACGCCTGGCCCTCTGGGTTACCAACCCTCAGGGTTATGAGGTGCTAGACAGGAAAAGGGTGGGCCCTGAT


CTCTGCCTCTCGCCAGCCAGGCCAAATTGGGGAAGTTCAGTAGTCCCCCAGTTTTTAGCAGGGTTGAGTGGGCTTTCTAGGGACTCT


GTCTCTGGGCTGTGAGTTTGCTGAGTCCTGCTGCCCGTTCCTCTCGGCTGGGCTGCGTGTTGTGGGAGGCCCAGTGTGCTAGTAGCC


CATGGCAAGCCCTCCCTTTAGCCTGTGTCCTGTCTGCCTTAACACCAGGCTTTGTTTTGGTAAGTGCTTTGTTTTGGAATCTTACCC


ACCGGTGGGATTTGGGTGGCCCTGTGGGGTGGGGTTACTACCTCTTTTCTTCACCTTCCCCCTCCATTGGCCCCAGCCAGTGGGGTC


TGCAGGAGTCCTGACTCACCTCCCTGATTCTCGTCACCCCCAGCCCCACTGAGCCCCCTCCTCCTCCCCAGAGCAGAGCCAGTGACC


TGGGACACAGCTTCACTGACACTCAGTCTGGCTCTGCCTGCTTGCTCACACACTGTCCGTGTCGGCCTAACTCAGGCCTCAATTTCT


CCATGTATTTAAGGCCCTTTCTTGTGTTTTATTTTACCTGATTTGGCTTTGTGTGGCTTTCCTTCCTTTTATACTAATGCTTCTCTC


TGATCTTATTTGCATTCAAATTACCTCGCCAGGTGGTTCACCAATCAGAGGTAAGAATGCTGTCCGTGCCTCTCGCCACACCACGCC


TTGCCACTGCCGTCACCTCCACTCCATCCCGTCCAGTCTGTCACCTCCCCATCCCCATCCCAACCTCTTCAGCCTCCTCATCTCCAG


CTCCAGCACCCCCAACACCACCGGCCACCACACACATCCACTCTCAGTCATTCCCTCCTGTGGACTCATCCATTGCAAGTCTGAATT


GTGAAGATACTCGCCGGGCCCCGCCTAGGACAGCAAGCCCTGCTGCCCAGGCCTTCCAGGCCATCCCCACAGAAGGGACCCCATCAG


CTCCTACTGTGAAACTTAGCCTGTCCCCCGGCTTCCCTAGACAGAAGAGCTTCCCTTGAGGTTGAGGAGTGTGACCAAGCCTTGCCT


TTTCTCTTGACAGTCTCTTTTGGGGGGACCTCAATTATTACTTGACTTTCCCTTTAGTATCCCGGCTCTGTACCGTGGTAGAATGAG


GATCATCCCTTCAGCCTGGCAAGGATTAGGAGGAATGTTCACTTAAGAGTTCTGTGTAGGTGCTAGGATGACAACAGGGAGGTAAAC


AGGCTCGTGCGTAACTCCATCACCTGACCTGTCAGCTCGGAGTCCCCGCTAGGCTCCCTCCACGCAGCAGGGCCCTGCAGCCTAAGA


GTTAAAAGCACAGATTCTGGACTCAGGAAGATCCAGGTTCAAATCTGACTTACCACCTATGTGATCTTCACAAACTCAGTTCATCTC


TCAGAAGTGTATTTCCTCTTTAAATTGGGTCACGGCCACCTGCCGCACAGGGTCATGAGAATTAGAGGAGAGGAGCATGTGTAGTGT


CTGGCGCAGAGCAGACACCTGTAAAATGGTGGCTTGTCTATTCACATCATTTTCTCTCCAGTTCTCTCAGTGTCTGGGCACATCTAG


ACCTTCAGAGCTCAGGACCAGGATGGTCTCAGGCAAGAGCAGCTGCCTTCCTGGGTGCTATCTTGCCCATCACCCGGAGGCTGGCTC


TTGCTTCACCTGGGAGCCCCCCAATCCCCCTGCCCATCTACTCAGCCTGTGGTGACTCTTTGTTGTCCCTGCTCCTGGGTCCTGGTG


TTGGTTCCAGATTTGGGGATTTCTGTATGCAAATAGGCACCCAGTCTCTGTTAGGCCCCCTGACCACTCTTAGGCTCTTGTTGCAGA


GGAACCTCCTATTTTCTGGGTCAGAAATTTCACCCAGGAACCACTTTCTGCCCCAAGCCTGTGGCACCAGCCACCAGGTCTCCCTCA


CCCCACCCACACCCCCCTGCCTCACTCAGGTGACCTTAGGGCAGCCTCGACCCCTCAGCGGCCTGAACCCGACCTGCTTGAAGGAAC


ATTTTCTGTACTAGTGTCCATCCATCCCATCAGCATGACCTGTTGGGTGCCCATCAGGGCTGCTCTTAAAGGAGATGGTATTTGGCA


TGTGCACTGGGCCCTGGTGCTCCCTGGCATCTGGTGGGGAGGGCTGAGGCCAGCACCAAAGAGGCAGGCTGGTCCTGCGTCCTGCAT


TGGTGGCCTCCCCTCTTCCTTCACCTCCAGCTGCCAGCCCCCTGGGGGTTCCCAGTCCCTCCTGCTGCCCTGGGTTAGATGGTGGAA


GAGGGACATCAGGTAGTGAGGTGGCTATAGGTCAGACCCAGGGTGGTACCCCTTTGGGCCCCAACCGTGAGAGCATGACTTGGAACT


CTTCCTCTGGCTCCTGTCCAGTCCAGGCAGGGGGGGCCCGGCAGCTTCTGTCCATGTCCTGTGTGGGTGTGATTGTCCATCAGCCTG


GGCCCTGGGAAGGTGGGGGCTGTCAGGTTAGGCTGGCTGTTCTGTGCAGGAGGTGGTTTTGTCAGACTGTGTCCTGTGGGGGTTCTT


AACTGTTGGACCGTCCTGTGTGGGTGTAATTGTCTGTTGGATTGTTCCAGGGAGGGGTGTGCTGCCTGTGCCCGGGGGTGTGTCTGT


CACAGACAGCTTGCCCAGTGTGCTTTCACAAGCAGTTTTTTCAAGTGTTTATTGGTGGGGCCAGGGGACGGCCAAGTCCAGTGGATC


CACCCCCACCTTGCCGCTCTGCCTTGGCCTCCCCCGCCAGGACCTGTCAGAACTGGCCTCAAGCCCAAGATTCCTCCACCCTTTCTG


AGGGTCCTTTTGCTACCCACCCCGATCCTGCCTCCTGTCTGTCCGTCTGCGGCCAGAGCAGCCCCTCAGGGCACTGGCCCGAGTGAG


AGCTCCAACCTCCATTAGCCTCTTGAATTATGCAGGAGCCGTGGTGGGTCGAAGCACTTTAGCAGGACCGGGCTGAGGAGTGGAGCT


GGAATGGGTGGGGCTGGCGGGGAGGGGGTGGAGTAGGAGGGGAAGATGGTGCTGGGAGCAGAGGCTGCTGGGCACCAGGCCCCCAGG


GCAAACCCATTCCTTCCTGGTGGGCGGCAAATTCTCAAGCTCCAGCCTGATGAGGGCATGGCGTGCTTGTGAATCCCAGGCCCGCCA


GTCTGCAGGCTGCTCCCACACCTGGCTCTGACTGGCTTAGTGGGGCTGCGGGGCCAGGAACACTAACAGGGATGTTGATTCGGAAAT


AGGCTCCAGTACTGGCAAGAGTGTGGCAGAAACTGAATGGAGCTGGGGGTTGGGGTACAGTCCCTGGCAGAGCAAAGGTGGGTCTTG


CTGGACTGTGGGGAGCATGAGATTGTGCTCCAAAGCACAACCGTTGGTTCTAGACAGGAGGCCACTGGGCTCTTCAGGGAGAGCTTC


CTGGAAGCAGCAGGGGTGCCAGGGTGTGGCCTGGATGAGCTTCGACATCTGGTCAACATCAGCCACAGATGCTGTCGAGACCTCTCA


CCGTGTTCCAGGCCACACTCGACATGGGCCGTGCCTGACCTCTCGCTTCGTGTACCCACAGGTGCCTTGCAGATAGAGAGCAGTGAG


GAATCCGACCAAGGCAAGTACGAGTGTGTGGCGACCAACTCGGCAGGCACACGTTACTCAGCCCCTGCGAACCTGTATGTGCGAGGT


AAGGACTCAGGCAGTGCCTGGCCCCTGTCACCACAGAGCTGTGCTGCACCTGCCGGGCTCTCTGCCCAGAGCCCTTGGTGCAGACAC


GCAAGGGACTGCCATGGGCCCAGTCTCTTCTCCTTCCTGCTTCTTTCTGCAGCAGCAGCAACAGCTCCCACTGGGCAAGTTCCTGGC


GTCTGCCACTACTTCGCCTTCCTTCCTTGCAGGCCCATGGGGAAGCAGCCACTCTTGGGAGCATTTGTATCTTTTGTAGGTCTTGCC


GCATGGGCCCGGAGCCCCATGGGAATTTGGAGCCATCCAATCCGACTTCTTGGTGTATGTGCATGTGTGTGTGCACACACGGGCACA


CTTATCTGTGTGTAAATGCATGCATACCTGGCCTGGCTTTCCTTCAGTACATCCTCCTGCCTGCCGCAGCATGGTGGGCTCCAGAAC


CACCATGGCTCTGGGCTTTGGGGTAGTAAGGCCTCAGGAACGGACCAGGCCAGGTGAGCCTATCCTCTGGCCAGGTCTTCCTGGAGC


CTTCCTGGAGGAACCCTTGTGTTCAGCTGTGAGCCCCTGTGGTTATGTTGCCTCGGGTGAGCACCTGGTGTGTTCCAGATGTTCTTT


GCTGGGAGCGAGTGGACAGTGTGCTTTCTGGAAGTCCAAGTTCCCAGCAGAGAGGAACCTGGGGACTGTTTTGGGGTTTCCAATCTC


TGCTATGCTCACAGCCTAGGGGTGACTAAAGCTGGCCACCTTGCCCTTTCCTGAGAACACACTGGGTCTGGTATACATGTGCCCAGA


AGGGGCCCTGAGAGCCCCTTCTACCCTCATACTGTCCCCTCACCTAGCCTTCTTGTACAGATGGATGTCATTAAAAGTTAAACTGTT


GACCGGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATCACGAGGTCAGGAGATCGAGACCATC


CTGGCCAACATGGTGAAACCCCGTCTCTACTAAAACTACAAAAATTAGCTGGGCGTGGTGGCGCGTGCCTGTAATCCCAGCTACTCA


GGAGGCTGAGGTAGGAAAATCGCTTGAACCAGAGGTTGCAGTGAGCCAAGGTCGCGCCACTGCACTCCAGCTTGGTGAAAGAGCAAG


ACTCCATCTCAAAAAAAAAAAAAAAGTACAACTGTCTCCACCCAGGGGATTGTAAAGGAAAGCGGACATGGCTCCTTGCAGTGATGA


TTCCATCACGCCAAGTGCTTAGCGCGGCTTCCTGAGGGGTGTCGTCTGACTCTCCACCCAGTGCACGTGGTGGGTGATGGCGGTGGC


CTGTCCGACTCTTTGGGGCCATGTGGTCAGACTTGCTTACTCAGAGCAGAGAGAATTAGGCTGTCAAGGCTGTCAACCAAAATACAC


TTATCAAGGAGTTGCTGTCTGTCATGGGAGAGGGTGGTTCTGGAGAGGCCACAGGCTGCCAGCCCATTCGGTGACCAGTTGAGCTGC


AGAGGAACTATTTGTGGTGGGCAAATTGTGCTTCAGAGACTATTAAAGATGCTTCATGAGAGTTGGGGGCATGGGATGGGAGGTCCC


CTAGCTTACTGTCAGGTGTCTTACTCCTCAAGGCTCAGGCCTCAGGTCAGCTTGTCTGTCTTCAGGAACAAGAGCCTGAAAACTTCC


CAAATGGCCTAGAGGAGTGGAGTTGTAAGCGGCACAGCCTTGGCCCCACCCTGCCCCAGGCAGAGTGTCTGGCAGGCATTGGGGCTG


GCGAGTCCACTCCAACAGAGGAGCAGCTGGAATGACCCTTCTCAAAGATCTGCCTCCTCCCACCCTGACTATCGCAAATGCTGTGCT


CTCTAGAGCTCTGCTCACAAGACTGTAGGGTCGAGAGTGGCAGTTCCAGGCCTCAGCAAGAAAGCCTTTGCATGTGGCTGCACCAGG


GAGAGGAGAGGCCCAGTAGAGCCACTGTAAACCCAAGCCAGCTGCAAGGGCGTGGCCTATGGGCACATTTCCCAGGGCACAGCTACA


GGAGGCAGTGCTGAGGCAGAAGAAGGCCCAGAGGTGGATGGACCCCCGCATTGTCCTCTTCACTAGGCAGCATTCTCTGAAGTCACT


GTTACACTGGCCCCAGCCCTGGAGGCAGAGCAGTGGGTCTCTTTGGAGATCGACTGAGCTCAGCTGCTGTAGCTGGCAGCTCAGTCA


CTGCCCAGGGAGCTCTTATGTGCAGCCCCTTGGAGCATCCCTGTCTGTGGGGCTCCCTGTTTACACATGGTAGACTCAGGCAGGGCC


CTGACTGGCTCTTGCCATGGCCCAACCCCTAACTCTACCAGCTCTTCTTGAATCTACCCTTCTGGCTCCATCCCCACATGCCTTTTG


GTAGGAAATACGGGGGTTCCTTTAGTTCCAGCCCCACTTGCCAGGGACTCCAAAACAGCCAAACCTGACTTCTGTTGTCTCTCTCAC


ACACACATACGACGTTCCTCTAGGCCCTGATGTCTCAGGACCGTTTCTAAGCTCTGTCCCCAGGACCTGCCTCATGTAGACCCTAAT


TGAATCTACACCACCCTGCTTTGCCAAGAGCAACCTGCCCCATAGGCCCTACTGTCCTACTGACAGGACTTAGGCACACCTGAAAGG


CCCTGCTCCCTGGGTGCCTTGCCTCTGGTGCCCCCACTGCTCGTCATCTCATGGTTGGCAAAACCCCTGCCTTCTGCCCTCACCAGT


ACTAGGGGCCCTTCAGCCCCAGCGCCTGGGGACAGCCTGTACTGGGCTGACCACCAGCTCTGCATCCTGAGCCCTGCTTGTGGGTGG


ATGGCCGTGGAGGAGTCCCCAGTGCCAGCCTGCTTTCTGGCCTGCACCCCGTCCCATCTCCCAGCAGAGAGGCTTCGAGGTTTCCTC


CCACAGCAGGCTCCTGAGCCTCAGACGGCTTGATGTGGGCTCTAGCCCTGAACTTCTCAGCCGCAGCACTGTTGACATTTTGGGCTG


GACGATTCTTAGTTGTGAGGGGCCATCCTGTGCATTGGAGGGTGTTTAGCAGCATCTCTAGCTCACTAGATGCCAGTGGCACCCCTC


AGTCAAAACAAACGTTGCAACGTGTCACCTGGGGGAAATTACTGATGGCTTCCCACTGCCATTGTCTCCACCCATCTGACTCTCTTC


ACCTGTGTCCACTGGCCGCAAGGCTTCGTCTCCTCATCAGACTTGGCTTCGGTGTCTACCTCACATCTCCCTTCTGTCCCCCAAATT


CTCAGGGCTCCCAGTGTCGCTCTCTGAGGCCACGCGACTGCTACATTTAATGGGACAGTACACGTGAAGCACCAGGCACATTGCCAG


GCACACAGGAAGCACTTGCTAGTCAGTAGCCTCTGCAGCTAGCACTCGGCTACTAGTCAGTAGCCTCTCGGATAGCACTGTGGGGGG


ATGTGTCATCCAGTTACATCTGACTTTGTTCACAGTTGCCTGCAGCTCCACCCACAGTCTAGCAGGCCCAGGCATGCTGCGTGGGCC


AGAGCCTTTCTCCTTCACCACCTGACTCTCCCTGAGTGACTCATTCTCTCCTTCCATCTACAGCTCTCTGGGTGTACAGCTGCTGGG


GCCAGGGTGGAGCCCTGCCCTCCTCAGAGCCTGGCCTACCTGTGCCAGCACTACCAGCCTTCCCCCTTTCTCTAGGGACCTGGCTGC


GGGGCCACAGCTGTCTAAAACAGGGACAGTGCCTTTTTCCCCACAGGTGCCCAGACATGCTCCTTACACCGGTGGTGTGTGTGGGGG


TGGCTTCTAGTGGCTCCTGTACCTTGGCAGGTTTGTGGGCTGGGTGGGCCTTGACCCCAGAGCCCGGTCCACAGGGTCTGTCTGAGC


TGTGGGGTGCGTGTGAGGCATGGGGGCCTGCCTGTGCCCCATTTTCACCTGCCCCGGCCCCACCCTCGGCCTCCCTGGCGCCTGCTG


GCGGGCCTCAGCCCTGTCCACCATGTCCTCCATGAGTCCTGAGTCTTTTGTGAGTGATGTGGTTCGTGTGCACCTGTGTGCATGTGT


GTGTGCGAGGGGGCACAGGAGTCTCGTCTCGTCTCCGTGCTGTGTGGGCAGATGAAGGTTGGCCTGTTTTTACTCTCTCTGTGTTTC


TCCTTGTCTTTTTTTTATTCCCTCCTCATCTTCATCGCACTCTGCCATCAACCCAAACTCTCATCTCTCAGATCAGCGAGAAGGTTG


GTCCTTTTCACTTCTTATCCATCTACAGTTCGCCCATCGATGGGACACGCCTGTCAGTAGGGCCCAGCGGGCTCGGTCAGCTCCCTC


AGGCTCACTGCGCCGTGCCTGCCTGCCAGTCTCTGTTGTTTGGGCCGGCGGGCAGGCAGGACCAGGGATGGGTGGGCAGACCCCTGA


CCTGCATGTTCCTGCTGCTTGGGTCCCTGGTGCACCACGTGTCTGCATGTCCCCTTAGCCTGGTTCCCCTGCAAGGGTGGTGGGGTG


GGCATGCTGCATGGCATGAAACTGTACCCCACCTTTGCACCCAGGCCGGGCCAGCTGTCTGATCCAGGCGGTGCTCAGGAATGGTTG


TGGGGGGCTGTGGTCAGAGAGAGGTGTAAGACCTGTAGCGCTTTGTGTGCACCTGTGGGACCTTTCACCGCCCTCCTCGCCTAGAGA


CCCAGGCTCAGCCGAAACTACTGGAACATTAAGGCGAGAGGCTAGAGCAGGCTGTCCTCCCAGTATCCTGCAGCACAGGGCAAAAGT


CCTGCAGTGTGTACCCTGTCCTTGAGGCCCTCAGGTCCCCCACCAGGGCTTAATGGGGCAGTCAGCCCTGGTCTGCCTCAGGGAGCT


TGGTGTCCATGGCGCAGGGTGAGTAGCGTCATCTTGGCACCCTGAGGAAGTCTCCCATAAGGTTGTCTTTTCCTTCTCCAGCCAGAT


CCAAATTAAGATCCTCCTACCTGCCCCAGGCCCCTCTGCCCAAGCTTCCCAGCTAGCTCCCGTGTCTGTTTGAGGGTGGAATTTAGC


CCACCAGCCAGCTAACTGACATTCCTTAGCTTGATGCTTTGCATTCAGACTCAAGTTGCTTCTACCTGGAGTAACTGAACGGTCAGC


TGCAACTTAGCAGGATCCATATGGGAGCCTGGAAGTGGCCCCTGACTCAGCCACAGGTTAGGAAGGGTTTCCTGGAGACTGTCCTTG


AGCCCATTCCAGAGCAGGTCTGTTTGGGGCTTGGTTTTCCGCCCCACCCTTGGAGCCAGACCCCCACCACTGATGCTGGGGTTGGCA


GCAGGGGCTAGTGGTCATTCATGTATCACATGGTCTGTGTGGTCAGAGGAGACTCACCTGTCCATTGGGTTTTGGGGGTTCAGGATA


GCAGTGTAGGACAGGCTGAGCCTCAGGGAGCAAACCCAGGCCATCCTCGTTCCCTCTGCCACATCCTCCGTGGCTTGAGTTTCCTCT


GTGAGGGTGAGGGAGCCGGTCGAGAGGAGGGCTATAGCCTAGGCTCAGATATCAGCCCTGAGCATCCATCCATATGCACAGCTGAGC


ACTGGGGCATTTCTGTTACACCATTTTGCTGACCGGGCAGATCTGCGAGGGCGTCCAGAAAACAGTCATCAGCAGAGACAGCCCAGC


CCAGAGTGGCTCCTTCCATGCCCCTTCCTCTACCCTCCTGGTCCCTCGTCCCCTCCCTTCCCCCACCCCACCCTATGGTCCCACCAA


AAATAAGCACATGGACAAATATTTAGCGGGAAGGCAGACATGAGTTTCTAAATATTCCAGGGGGATTTGCCGGGCTGGTAATTTGTT


TGGTGCTGATAATTGCATCTTACATTTTTCCAGCTTTACTTAAAACTGTGTGCCGGGTTTGCCGGCATTTAATTACTGCTCTGCGGC


AGCCACAAGGTTATTTATTAAAGAGTTATTTTATCTTGATACAGTGGATCCTGCCCCTCATCCCCTCCTTAATGTTGTGTTATTTTC


ATCAGAGAAATTTCTCTGAGTGAATGCAGATTGCGGGGCTGCCTCCCCCTGCGATTAGGCTGTCACTCTACTGAATGCTGATGCCTC


TGGGCGCCGCACCGCCCTATTATAGGGGGTTGTCAGCGCAAATAATTAGACTTAAAAGTTACAGCTGAAATATAATCCAGAAATGGC


AGGGCCCTGTTTTGGAAATTGTCTATAAAATGTCAGCACTAAGGATGCACAGGGAACGGTAATATACTGGCATTGTTGGAGCCTAAG


ATTAGACCCTGAGTGCATTTTTCCCAGCTCCAGTTTTTCTTTCCCTGCTGTTGCTTCTGTCAATAGACTGTCCAGGGTGAGGCCTGT


TCCTTTTTGGAGGCCCTGTGCCTGCAGCAGTGGGTGGAGGATGGTTGGGGCTGCTGCAGTGAGATGCCAGCCACTCCAGCTGTTGGC


ATGGGGGTGGCTGTCTGGGCAGGTCTAGGATGCGGGTCCCTGTTGGCACTTGGAATACAAGGAGGTTGTCCCTTGCCTGTTTCCCCC


ACCCTTCCTCTGTAGACATACCCTGACCTCCCTCACATGGAAAATGTCTCAGTCTCAGTAACGTTTCTGCGTGGCTGAAGCCCAGTG


TCCTTGTGAGAGTGAAGGTGGTGTGCCCAGGAGCCTCTGGACCTGAGGCCCTTGCTTGGTGTTGCAGGTGACCCTAAAGGCCACTGT


TGACCTCTCACACTTATGCCTAGCCCCTAGAGCTCTCCCTGCCCCCTGCATCTAGGAGGGAAAAAATAAACACAACTCTTCTGTGAA


GCGCCTCAATTTCCTGACAGCCGCAGGAGTTGGAGGCTTTAGAAGACGTGGCTCAGGGCGTTGGCCTGACCTCCAGGGCTGATCCAT


GAAGTCCGCCTTTTGGCCTGAAGACCCTGTCCTCCAGGGACAATTTGGGGGTAAAGTCCAGTCAAGTTTCTAGGTTGGTGCCCAAGG


TTTATTGGCCAAGGACCTACTTCCTTCTGCTGGGGCTCTTTGTCCTGGTATCCAACGACGTGATTAGGCCCCATGATTCCACCACCG


ACTGGGGTCAAGCCTGCAATCATGACCTCTCCCTGGCACAGGCTGTCTAAACCCATCCTTACGCCCGCTGGAGCAGCGTCCTCTCCT


GCCAGCCTCTGCTAATTCTGATGCTTCTCCCCAGAGCCTTCTGGGTCTTTTTTCAGGCCTGTCAGCTAGGGCTCGAAAGGGTGACAG


TTTTTCATCACACAGACCTACTCCTACTACGTATATAAACTTGGTCATGTGGCTTGGTTTTAAAACAGTTCCCTTGACTGTAATTGG


CAGGTGATAGCATCTACAGCATGGAAACCTGCACCTAGTAGGTGCTTAAGCATAGCTTCCCTTCCCATGAAGAGGAGGAGACAGGGC


ACCCACTGGCCGAGAGGACAGGAGAGATTTAGTTCATTAAGGCTGCTCCTCTGTGCTGCCCCCACCCCGCTTCTGTGGCAGGCCTGG


ACCTGATCTGCAAACAGACTTGCCTGCCTGTGCCTGTCCCTGAGGCCCATCTCCAGAGCAGAGGGAGGGCATGCACCGCTGGGCTGG


GTGGTGGTCCTGGCTGAGCCTCCTGCTCTCACCTTGGACCATTTGACGTGCGTGCTCAGAGAGTCCTTTGTTGCCATGAGACACTTG


CCAGCCATGCCCCGGGATCCACCTGTTCTGCCACAAGAACTGTGTCTGTGACATGCTGTCATCATTGGTAGAGACTCCTGGCACTAG


AACAGATGACAGAAACCCACTTATACCAGCGTAAGCAAAACAAGGAAGTCCTGTGTTACAAATCTGAAAAGTGTAGTAGATTTGGTG


CTGGGCAGGGCTAGATCCAGGTACTTAAACAGGTTGGCCAGTCATTTGTCTGTCTGTTTCTGAGCTCTCCTCTCCTCTGTCGACATC


TTTGTTCTCAAGCAGCTTTTCCTGTGTGTTGGGAGAAGCCATCCCCAGCTGCTCTAAGCTTAGCTACCTCAGTAGAGAGAGAAGGTC


GCTTTTCTAATAGTTTCTGCGGAAGTCCAAAGGCTGTTTCTCCATAGTCAGATCTGGGTCACACACCCCATGTATGAAGAATGCAGG


TAGAAGTGGTTTCCTTAAAGACAATGGGAATGCTCATTGATTTGAGGAGAAAGCAGAACCCTGAATGTCTACAAGATACTCTCATGC


CCTAGGTGAACCTGGGGACACAGATCCAGCCCACCAGCACCTGTCAGGCCTGGTCTCTGGGGCTGCCAGGGTTTGGGTTCTGTCTGG


AGCACCAGAGTAAGGCAGGCTGTGGAAGCAGTTGAAGCAAGTGCTAAATTAGGTAGGGTCTCTTGGGCTGGGCAGAGGAGTCACTGG


GAGCCATGCAGGAGCTTGTTAAACAGGGAGTGGCATCAGATTTGTGCCAGCTGTTTGTGGAGGGCCCGTGAGCAGGAATTGGGGCAG


TCGACAACAAGGCAGGAGGACTGACGCAGAACACATTGCAGCAACTCAGGGAAGGATGATGATGGCTTGGACTTTGGTGGTGGCAGT


TGCCTGTGTGTATGGAGAGAAATACATGGATTTGGAAGATATGTTATGCCACGCTGTTGACAGGACCTGGTGACTTGCTGAATGTCT


GATCTCTGGGTCTAAGTTTTGACCCCTGTATGGTGAGGTCAGACGTTGGACCGGGAGGTCTCTGAAGTTGCTTCTAGCTCTAGTTCT


GTGATTTGGGGCTGTGTGAGCAGCATAGTCTGGTGCTTATAGTGGAGATGCTCTTTATGTGGTGCTGTGGGGTCTTTGCATGCCTGG


GCCCCCCAGCGAGGGTCCTCAGAGACCAGTGCTCTCAGCAGTGCTCTTGGGTACTGACTAGCCTGCTGCCTGCCGCCTTTGGCCCTG


CGTGTGAGAGTGCCCGTGTAGGACACACCCTGGCCTCTGCTCACCAGCTGCATGGCCCATCTGCATGCCAGACATGCCTGCCCACGG


CTGGGTTTCATCACCTCCCTTCCCTCTGCATGCTCCTGTGTCTGTGTCAAGCTTCCAACTTCGGGGGCGGGTGGTTCTAGGCTGTAC


CCTGGACTGAGAAGCTCAGAACAGCTTCTGGTCAGGGGAGTCCAAGGCTGGAGGTCGTGGCCAGGCACAGCCACAGCCACCCCTCCC


CTTGAGACCCTTGTTTGTTGCCGCAGGAAGCCGTCTGTTCGGCGCCCTCATCATGTTACTGCCATCGTCATGCCCATCCTGCCCGCA


GACCATGTCCCTGGCCTGCCCTGACCCCTGCCCCTCCCCAGTCCTCCTGAGGGCAGCCCTTTTGCTTGGGTTCCCAGGTTGTGCCCT


GAGCATGGCTGAGACCCTGGCAGGCGGCCCTGCTGCTTGCCTTATTTCTTCCCCTCAGGCCATGGCCTGGAGGTGGAGGCAGTGACT


CCACGGCAGGTGGCTGTGTCCCTCTGGACTGGCCTTCTGCTCTGCCCAGCCATGCTCTGAGGACCCTCCACCCTAGGGCCTGCTTTC


TCTCCTTGGTGCTCCAGCCAGGAGCAGGCAGAGATAGGCCCTGGAGAACACCCTGGGTTGTGGTCCTGACCAGGCCTGGACCTTGTA


CTGAGTCCCTGTGTGACCCTGGGCAGACAGGACCTTCCTGACAGGCCTCAGTTTCCTAGGCTATAAAATGGGAGCTTGGTTGCAAGA


TCTCTCATTGAGTAAGTCATCGTGCtCCAGACAGTCCCTGAGTGTGGGGGCCACTTCTAGGCTGGAAGTGGGTGGGGTGGGAGTGGA


TGATGAGCTGGGGTCTGGCGGTGCCACCCCTCCTGTCTCTGAGCATGGGTTTGGCTCTGACCAGAGGGGCTTCCTGAATGAGGGGCC


CCTGCCCTTCCATGCAGTCGTGTGTCCTGCCCGGCCTGTGAGTGCCTCTCTCCCTCCTCCTGCAGTGCGCCGCGTGGCTCCTCGTTT


CTCCATCCCTCCCAGCAGCCAGGAGGTGATGCCAGGCGGCAGCGTGAACCTGACATGCGTGGCAGTGGGTGCACCCATGCCCTACGT


GAAGTGGATGATGGGGGCCGAGGAGCTCACCAAGGAGGATGAGATGCCAGTTGGCCGCAACGTCCTGGAGCTCAGCAATGTCGTACG


CTCTGCCAACTACACCTGTGTGGCCATCTCCTCGCTGGGCATGATCGAGGCCACAGCCCAGGTCACAGTGAAAGGTGAGTGTGGCAG


GTGCTGTAACCAGTGCCCTCCCTGTCATCTGGGAGGTCCTGGTGGTGGGCGAATGTGAGCTGGCTGCCATGGGCACAGGCATGGCTG


AGGGATTCTTGCCCTTTCCTGGGTGTCCCTGCCCTGGGGTCCTCCAGCCCTTAGAGGGAGGGAGGGATTTCTGTTATTAGCCGGCTT


AATGATAATAGTTAAGGCATATTGAGTTTCTTGGTGGGAGACATCATGCTAGCAAGCACAGTTGATTTTGTTTTTTTCTGTTTTACC


CTGGGAGATAGGTGCTCTTATTATTTCCATTTTTGAAACGAGGGAACCGAGGCACAGAGAGGGTGTATCACTTGCCCCAGGGTCACA


TAAAAATAAATGACAGAGCAGGGACTTAAACCCAGTGTGGTCTGAATCCATATCTCACCCTCACCACTACATAGTACCAGACCTTCA


GGTTTAATAGCCTCCCAGCAAGAAGGGTGTGGTAAAATAGTAGGGGAAAGTGTGTTCTCTCTGCCCTGATACCTGGGGACAGGCACA


CATGTATTACACATATGTCACATATATGTAACCGATTCTGGCCAGGCACGGTGGCTCATTCCTGTAAGCCTAGCGCTTTGGGAGGCC


AAAAAAACTGGGCATGGTGGCACACACCTGTGGCCCAGCTACTTGGGAGGGCTGAGACAGGAGGATCACTTGAGCCCAGGAGGGTGA


GGCTACAGTGACGCAGTGAGCCATGATCACACCACTGCACTCCAGCCTGAGTGACAGAGCGAGACCCTATGAAAAAAAAAAAAACCA


GATTCCTTCCTGGTCTCCCCGCTGCAATTCTCAACAGCCTCTGATCCATTATCTGTTTTGCAGCTTGAGTGATCTTTAAAAAATGTA


ATTCAGGATCAAGTGACTCCCTTTTAGGAAAGGGAGAAACACCTTCCAGTGGCTTCCCGTTGTTTTAGGATACAGATCAGGATCCTC


ACTGTGGTCTCCCAGGGCCACTGGCTTCCCACCCTGTCACGCGCCAGCTGTCCAGACACATGCTGCTTTCCGTTTGCCGTGCTCCTT


GCCTGGCCCCTTCTCTCACTGGCTCCATGTACCCTTCCAGGCCTCAGCTTGGTGATGCTTTCCTTCCCTCATCACCGCATCCAAGGA


GATTCCCTGGATCTTACTCCACCTCAGCACCCTGATTCCTGCTGTCCTTGCACATGGCAGAATCATGAGTACGATCGACTTGTTTAT


TGATTCTCTCTTGTACTGAGGTGTAAACTCCATGAGAGCAGGGATGTGACTGTGTGGCATTGTAGCCCCAGCACAATGTCTGGCATT


GAGTGGGTGCTTGTTAATTATTTGTTGAATGACTGTGGACTCAGGACCTTTCCACTTCAATTTGAGCCAAGCTGCAGGGTCTGTGGG


GCCAGCAGCCCCATCACTCTTTCTATCCGGGCCAGTCCCTAAGGAAATATCTCCCCTTCCCCTGCCTATTACACATACTTTCCACCA


GGTGGGCTCAGGTGACCTGCAGAGGCACATAGCTGCTACCCAGTCTGGGTGTCTTTCATCTACATGGGACTGCAAGGGTCACATCAC


CTCCAGGTCTGTTTGTTAGATGAGTCTGGTGTGCTGATGGGAGGGTCCAGTGAATCCCACAGTTGATATGTGTACATACTAAATGAC


CCAAGGCCCTGGGTGGGGCACTGACAGGCCTGGCCACTGTCCCTCACTTGTGCCTTCAGAGGTCACCATAAGCTTTTCCAGCCATTT


TTCAAGGTAGGCTGTGGGTATCAGCCACACTCAGGTGACCCCACCAGATATCCTGGATAATCCCCAAGTCTAGGGTTGGTTCCTAAG


GATCTTGACCTCGGGCAGCTTTGAGCCTTCCACTTTGTCTCCAGCTCTTCCAAAGCCTCCGATTGATCTTGTGGTGACAGAGACAAC


TGCCACCAGTGTCACCCTCACCTGGGACTCTGGGAACTCGGAGCCTGTAACCTACTATGGCATCCAGTACCGCGCAGCGGGCACGGA


GGGCCCCTTTCAGGAGGTGGATGGTGTGGCCACCACCCGCTACAGCATTGGCGGCCTCAGCCCTTTCTCGGAATATGCCTTCCGCGT


GCTGGCGGTGAACAGCATCGGGCGAGGGCCGCCCAGCGAGGCAGTGCGGGCACGCACGGGAGAACAGGCGCCCTCCAGCCCACCGCG


CCGCGTGCAGGCACGCATGCTGAGCGCCAGCACCATGCTGGTGCAGTGGGAGCCTCCCGAGGAGCCCAACGGCCTGGTGCGGGGATA


CCGCGTCTACTATACTCCGGACTCCCGCCGCCCCCCGAACGCCTGGCACAAGCACAACACCGACGCGGGGCTCCTCACGACCGTGGG


CAGCCTGCTGCCTGGCATCACCTACAGCCTGCGCGTGCTTGCCTTCACCGCCGTGGGCGATGGCCCTCCCAGCCCCACCATCCAGGT


CAAGACGCAGCAGGGAGGTAGGTGGGGGCATGCCGGCTGGGCAGCCAACAGCAGAGAAGGGGAGGCTGAGGTTGTGGCGGTGCCTTT


CCCCCTCCCTCGGCTGTGAGGCTGGGGGCTCTTGGGAGGATCAAGGTGCCGTATTCCATAGATGTGTGGTCAGTTGGGATGTAGGAT


AAGGGTGTGAGGTTAGGACCTGACTTCCTCGGCTCCCTCCTCCCTGGGCACCCCTGACCTCACGCAGATGAGGCTGACCTGCCTGGT


GTGGGGTGTTGCAGTGCCTGCCCAGCCCGCGGACTTCCAGGCCGAGGTGGAGTCGGACACCAGGATCCAGCTCTCGTGGCTGCTGCC


CCCTCAGGAGCGGATCATCATGTATGAACTGGTGTACTGGGCGGCAGAGGACGAAGACCAACAGGTGTGCAGCGGGCAGAGAAGCAC


TGAGGGGGTCTCCTGGTCCCTGAGGGTCTGTGATGGGCTTAACCCAGGAGGGTATTTTCTGGATTCTGTGGCTTATGTGGGCACAGC


CTCTAAGGTTTCTGCTGGAGGCTTAGTGGTGCATGCGTGTCATGTGGCCCGCACAGCCTGTATGAATCTGGAGTCATTGTCACCCTG


TGCTAGGGGCAAAGTCCCCAGGGTCTGCCTTGGGTTTCCTAGGCTCTGTGGCTCATATGACTGGCAGAGCCCTGAAGTTTCCCCAGA


AGCCATGCGTCCCAGATGGCTCCTGTGGTCCATGTGGTCTGTGAGGTGTCTGTGGCATGGGCTAAGCCCTGAGTTCCTTTTGTGCTC


CATGTGGCCTTATGGTGTGGAGCCAGTCCTGGAGCCGTGGTGGGTCCAGAGGTGTCACATTGCAGCCCATGTTGGGGAACAACCTGT


GAGTGACTTTGAGCTCAGAGCTGTCAGTGAGTGCTCCCTGCTCTTCCCAGCACAAGGTGACCTTCGACCCAACCTCCTCCTACACAC


TAGAGGACCTGAAGCCTGACACACTCTACCGCTTCCAGCTGGCTGCACGCTCGGATATGGGGGTGGGCGTCTTCACCCCCACCATTG


AGGCCCGCACAGCCCAGTCCAGTAAGTGTCTCCCAAGTCCGCTGCCTGTTACACCTGGGCTGGGACACACACACACACATGCACACA


CATCCTTCCCCCTCGACCAGGCAGGTGGGGTGGTCAGGTCTGCTGGCCAAACCGAACTCTGGCCTGGGCTCTGAGTCTGGGCCTCGG


GAGAGGGCCAGGTAAGTGCCTCCCAGTCTGTCCAGTCCAGGCGGCTGCTGCCCTCCCTGCTCCCTGCCCAGCCTCCTGCCCCTCCTC


CCGCCCATGCCCCACACACTGCCCAGGTAAGTTCTGTGTCTGTGCCTCATCTCCGCCCCCACTCTGTGCTGGTCACACTAGCTTAGC


TGATGGGCCATCCTCGGTGGGTCTGCCATGTCCCAGACCTGCTTTGOCGGCTGTTTCTCCTCCCTATGGCCCCGCATCTCGTCTCCC


CATCACCCACATTCCCTTCCTCATACTCCCCATGAAAGTTACCTGAGAGCCATGTGATCACCCTGAGCTGACTGCACTCGGGGACAG


GTCTGAGAATGCGGCCATGTGACCCAGCCTGCCCACGTGTGCCTTGAATTGTGACCACGTGGCCGTGCAGGGGACTGTCTGCAAGGC


TGTCTGTGTGAGACTCTGGTGTTGTGTGTGAGAGACTCCGATGCTGCAGCTGTGGGAGTGGCACTGCCCATGAGTGTGAGTGTGTGA


CCACACCTGACCAGCTGGCTGTGCAGCACCTGTGTATGTGCATCAGTGGATCTTGGGCATGACCCTTGTCTTTGTGGGCGACTCTGG


CCTCATCCTGTAACCGTATTTGTGGGTCTCGGTAGCCCCCCAGACAGTAGACTGTGTGTGTGTGTGACTCTGTGGTTGCTGCTGGGC


GTCCTGTGTGTGGTCACACAGCCACAGTCAGCTGCTGCGTGAGACTCTGTGTGATAGGGTGTCATGGATGTGACTGCCTGGGTAGCA


TTGTGGGATTGAGATGGTGACCACATCTGATGTGGCCATGTGATCACCAGAAACATGGCGGTGTCTGAAGTGGTCCTTATGAAGTGG


GTTATGGTCACAAGGTAAGCCACCGTGCCTGGCTCTTCCATCCTACTTTACACAAATGTCATTAAAAGCTCATTTGGAGGCCAGGCA


CGGTGGCTCACACCTGTAATCCCAGCACTTTGGGGAGGCCAAGGTGGGCGGATCACCTGAGGTCAGGAGTTAGAGACCAGCCTGGCC


AACATGGTGAAACTTTGTCTTTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGTGGTTGCCTGCAATCCCACATACTCGGGAGGC


TGAGGCAGGAGAATCACTTGACCCCAGCAGGCAGAGGTTGCAGTGAGCCGAGATGGTGCCATTGTACTGCAGCCTGGGTGACGAGCA


AAACTCCGTCTTGAAAAATAAATAAAATAAAAAAGCTCATTTGGGTAATTACAGGTGCAATGTCTGTCTGCCCTGCTGGAATGCAGG


ATCCCCATGGGCAGACACCATGTGTCTGGTCATGCTGCCAGCCCTGTACCGTGCATGGGGCCTGGCCCCCACCTGCAGCACAGCAGG


TGCTTCTGGAATGAATCCATGAATACAAGGTCACACACAGCCTCTTGACATCACTGGTACATGCACATGTACCCTGCTCCTGTTCAT


TTACCAGTTGGCTCCCACCCTTCCTTCAGGCCTTGGGAAAGTGTCACCTCCCCAAGGCCTGAAGGAAGGGTGGGAGCCAACTGGTAA


ATGAACAGGAGCAGGGAGCACACAGGCCTCCGGGAGAGTCTGCAGGCCTGAACGCCTTCCACCTGCAAGGCACATGGTTATGGTCAC


AAGGTAAGCAGCAGGCCAGTGTGGCTGCAGTAGCTGCCGGATCTATGGCAGTCAGGGCCTTGGGGACACAGGGTAGGCAGGAGAGCT


GACTCTGGCTGCTCTGTGAGAATGGACAGGGCAGCCTGTGAGGAAGCAGAGACCGGTTAGGAGGCTTTGTAGCCGTCCAGGGAAAAG


ATGGTGGCGCAGGTGAGGTGATGGCGGTGGATCTGAGAACTGTCAGGGATGCTGACTGGTCAGACTTGGTAATGGGTTATGAATAGG


GGCCCAGGGGGAGGGAAGTGGAGGTGAATCTTGTTTCTGGTGTATTAACCTGGGAGGAGAGTGGTGCTGGCGTAGAATGGGAAATGG


GGCAGAGGCAGGTGTGAAAACTACAGCTGGTCTCAGACACCCAAGTTCAAGATGCCGTGTGCCATCTACATGGCAGTGCTCGGCAGG


CTGTGGGAATCCAGGGCTGGGCTGGAGCTAAAGGACCCTGAGAAGAAAGACTGCAGATGAGAGGAAATCAGGGGAGGGGAGCGACTT


GGAGGTTGGAAGGAGAGAAAGTTTCAAGAACTAGACGAGATGCTGCTGAGCGGTCAGGAGTACCTGTTGGACCGAGCAACATGGACG


AGTGGCCCTGGAGATGAAGCTTGGTGCATGGTAGGACCAAAGCTGGTGGATGTTTCATGAGGCCTGTGTGGGTGCTGAGAATGTGGA


GGCAGCAAGCCTAGACGTTGCCAGAAAGTGTAGCTCTGAACAAGGGGACCACTATGGCTAGAGAGGGCCGTGGAGCTGAGGGTGGGA


TTTTGTTTTGTTTTGTTTTGTTTTGTTTTTGTTTTTTTGAGACAAAGTGTTGCTCTGTCTCCCAGGCTGGAGTGCAGTGGCATGATC


TTGGCTCACTGCAACCTCCGTCCACCTCCTGGGTTCAGGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGTTTATAGGCGTGCC


CGCCACCACACCCAGCTAATTTTTTTTTTGTAATTTTAGTAGAGACAGTGTTTCACCGTGTTAGCCAGGGTGGTCTGGATCTCCTGA


CCTCGTGATCCGCCCGCCTCGACCTCCCAAGGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCTGGGATTTTTCTTTTAAGA


TGGGAAAATTTCAAGCATATTTAAATGCTATTGGAAACAGTCAATAGGAAAAAAAGAAACCGTGGAAAAGAGGGTAACTGGTGGAGC


CTTGGGAGGTGGAGAGAAGGGGAACAGTATGGGTGGTGAGAGAGCTTAGCCTTGGACAGGGTGGCTCAACTCTCCATTCTCATGGGT


GGAAAGGAGAGAATTGCTGCAGATGCAAGTACGGTGGGGGGGTTGTAGCAAGAGATGGAGGGAGCTGCTGTGAAAGCCTGGTCTTCT


CTGCAGTGTGGGAGACATGGTCATGCGCCAAGAGGAGGCAGGCAAAGGGAGCTGGAGGTCTGGGGAGCATGGAGGAGGGGGACTGTT


TCATGTGAGGTGGCAGAGCGAGCCAGGCAGGGGGCAGAAACAGGCAGCATGGAGAGTCCTGGAGGATGAGGCCTCTAGGGACGTGTG


CATAGGACGCCAGCCTGCCTCAGTGCCGCTGTAGAGAAGGAGGGGGAGAGCTGGATTCATCTAGGGCTTGGCAGCGGCCAGGAAGGA


GCATGGAAAGATCAGGAGGCGAGGGACCTTGCGATATTGGTGAGAGTGTGGTAGGTGGTAGACTGTGGAAGCTGAACATGGAGGGTG


GGAAGGACAAGGTTGATGGACAGGCATCCTGAGGAGCTGGCGAGCAGGCTCAGTGCCCGGGGCCTGGAGTGACTGAGCAAGAACAAG


GGGGTGGGGTCTGCAAGGGGATGTGAGAGCCCGTGATTCTGGAGGGAGGGCCATCCCCAGTACTGGCAGCCTCCAGGGCATGACCAC


AGCTGTGCAGGGGAGGAGAAAGTCCTGGAGATGAGGGGCTCTGGGGCCAGTGGGTCAAGGGGCTGCTGAAGTCCCCATGGCAGGGGG


TGGTGACAGAACTTGAAGAGGAAACCTGTGCATTGCAGCAGAGTCCTCGGTGGGCGTGGAGTCTGGACACATCACTGGACACAAGGA


GACACGTGTCTGCCTCCTAATTCCCAAAGAAGCTGTTGAGTGAGGGCACCTCTGTTGGTGGGTACTTTTTCTCCACGCCAGGGGCTG


TTGGCCTTCATGTTCGGCCTCCTGTTGGTGATTACCTGTGGCACTGGCAAAGAGACTGTTTCCAGGCAGGCACAGGTGAAGGCTGCC


TTATGCCAAAAGGGCCACTGGGGCCACTCTTCCTCGGAAGAGCAGAACCGTGGGCACAGCAGATGTGAAGCAGTTCTCCATATGTGG


CTGTGTGTGCGGGTGGCAGTGGGATGGCCACGTGCTTGTGTGTATGTGATATCGTGTATGTTTTGTGTGAGACAGCATATGTGTGGG


AGAGACCTCGTGTGAGAGATGCTGTGTCAGAACTCTAAGACATTGTGTGTGAGAGTGTGTGTCAGATGCCATGTGTGAGACACCAAG


ACACGGGTATGTGATACTCTGTGTATATGTGAGTCTGTGTGAGAGACACTGATACTCCAAGACATTGTGTGTGTGTGACACTGTGAG


ACACCAAGACAGTATATGTGCGAGACAGCCTATGTATGTGACAGTGTGTGTGTGAGACACCATGAGAGACTGTGTATTTACTGTGAG


AGACTGTGTGAGAGACACGTGTGAGACACTGTGTATATGACACTATGTATACGTGAGACTGTGAGACACTATGTGTATGTGACACTG


TATATGTGTGAGACCGTATGAGACAGTGTATATGACACTGTATATGTGTGAGACTGTGTGTGTGAAACACTATATGACACTGTATAT


GTGTGACACTGTATATGACACTATATGTGGAGACTATGTGTGAGACACTATGTATATGTGACACTATGTATGTGTGTGACACTGTGA


GAGACACTGTGAGACACCAAGACAGTATATGTATGAGACACCCTGTGTGTGTGACACAGCGTGTGACTGTGTGAGACGTGTGTGAGG


CACTGAGACTGACACTGTGTGTGAGGCTGTGTGAGAGTCAGTGTGTGTGATAACTGTGTGTGTATCACCGTGTGTGTGTGTGAGAGA


GGGAAGGAGAGAGAGGGAGGCAGGTCAGAGGGAGTCAGGCGTCCTTGGCGAGAGTGGCAGCAGCCTGCCTGGAGGGACCCTGGGATG


GCCATTTCAGCACCTAAGGGGTAGCCTGCCCGGGTGAGTCTCCAGTCCACTGTGACTCAGTCATTGTGCCTGTGATCCCCACCCTCC


ATCTGCTTGCTTCCCCCCCATTTGTCTTCCCCAGCCCCCTCCGCCCCTCCCCAGAAGGTGATGTGTGTGAGCATGGGCTCCACCACG


GTCCGGGTAAGTTGGGTCCCGCCGCCTGCCGACAGCCGCAACGGCGTTATCACCCAGTACTCCGTGGCCTACGAGGCGGTGGACGGC


GAGGACCGCGGGCGGCATGTGGTGGATGGCATCAGCCGTGAGCACTCCAGCTGGGACCTGGTGGGCCTGGAGAAGTGGACGGAGTAC


CGGGTGTGGGTGCGGGCACACACAGACGTGGGCCCCGGCCCCGAGAGCAGCCCGGTGCTGGTGCGCACCGATGAGGACGGTAGGCAG


TGCCACCGGGGCGGGAGGGGAGGCGTTCTGCCTCAGACACCACCCACCAAGCTCCCCAGGGCCTTCCTTTCCTGAACACAGGCCCAG


GTCAACTCATCTTTCTGGTTCAGGTGTAATGGCCTAAAGTGGGGGGATGTCACTTACGGGATAACTGAGGCCCAAATCCCAGCCTTT


GGGGCTGTCTCCAAAGCAGCTGAAACCTTCACAGGCTAAGATGGGAGAAGCAGCCCTGTCTAAGATTTGAAAGGTCAAGATTGGGCA


GATTGGTGTAAAAGATACTCAAAGTAGAATCAGCAAGACTCCACGTTGGCTGGACATTGGCATGATTGGGGCCTAGGAGGAGTCAGG


ACAGGTTGTGCTGACTAGGGGTGGTCAAAGACCTGGTGCCCCACCTCCACCTGTTCCCCCATGTCGACCCTCCCCACCAAGTGAGAG


GCCTGGGCCAGAGGGGTGGGCAGGGCCAGTCCTGGGCTCTTACCCGTGGCGGGCAGAGGGAGCCTTCCGTGTGCCTCACCAGGGACA


GATGATCTAAGGAAACTGTATCAGGGCCTTTCCTGGGGGAGTGGGGTGCTGAGGCAGGACCCTCAAGTTTGCTGTGCCCACCTGAGC


TAGGGTTGATACCTCCAGGCCTGACTTCCTTCTCTACCTGACCCCCCAGTGCCCAGCGGGCCTCCGCGGAAGGTGGAGGTGGAGCCA


CTGAACTCCACTGCTGTGCATGTCTACTGGAAGCTGCCTGTCCCCAGCAAGCAGCATGGCCAGATCCGCGGCTACCAGGTCACCTAC


GTGCGGCTGGAGAATGGCGAGCCCCGTGGACTCCCCATCATCCAAGACGTCATGCTAGCCGAGGCCCAGGTGCAGCATTGGGTGGTG


GTGGGGTGGCAGGGTGAGCACAGACCAGCATGCACAAGCTCCCTTTTGGGGCCCAGATATGTCCCTCTTCCCCTGCCTGCCCTCAGC


AGTGCTGTGACTGCCTTTCCTTGGTTGTGAGACCCGAGATGCTTTGCAGCATCAGGGGTTAGGCTGGGGTTTTTTGGGTGTGGGTTT


TTTGTTTGTTTGTTTGTTTTGAGATAGAGCTTCACTCTTGTCGCCTAGGCTGGAGTGCCTCCTGGGTTCAAGCAATTCTCCTTCCTC


AGCCTCCCGAGTAGCTGGGATTACAGGCGTCTGCCACTGCGCCTAGCCAATTTTCGTATTTTTAGTAGAGACAGGGTTTCACCATAT


TGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCTGCCTCAGTCTCCCAGAGTGCTGAGAATACAGGTGTTAGCCACTG


TGCCCCACCAGGTCGGGGTTTTGAGATGTGCCTTTCCCCTAGACAGTGCTGGGCTGGCATCCACTCTTCCCACAGAAAGGGTAGAGA


GAGTGCTCCAGGGCTGTCTTACCCCACTGGCGGCCATGGGTCCGTGGTTGCTGCAAAGCTCTGTGAGTAGCCAAGTAGAGTGTTGCC


CTGCTCCTGGCCCTGCAGGGAACGATTCAGCCCCTGATGTTCACCCTCAAGAGCTAGGCCTGCTGGCCAGCCTCACACCTCCCTCTG


TGCACATCTGTCTTCCTGGGAGGATGGTCCTGCCCTTGAGCTTGGGGTGAGGTCCCTGGGGTATTCTGAACACTGGTTGCTATTCAG


ATGAAGAACTTGGAATGCTGGGGGGTTATGAGAGTGGTATGGAATTATTCAGCAAGTAGGTGGCTGCTGCGCTTGGATGAGAAGCCA


TCTCTGTGGACCCCTAGGAAAGGGCCACAGTTGCTGTCATGAGCCCCCTCCCAAAAGACCCTGCTGGAGAGTCACAACACCTGGTGT


CGTGCTCTCAAGGTCTCCCTATCCAGGAGCAGGGCCTCCCCATTGAGCCTCTCACCTCTGCCTGGGTGGAGAGCAGGGGTGCGTGTA


CCACTCAATGCTGTACACACTGTGCAGAGGGGTGGGGTCACCCACACAGACAGGAGCCTTATTCCTCCAGCTGGGCTCAGCCATCTG


AAGCAAAATTCTTTCTGCCCAGAGGGTGCTCTCTTCCCCCTCTCAGCCTGCCCAGTGCTAAGGCATCCGGGGTGGAGGAGGCAGGCA


TGTGCACCCACCTGCATTCCTGGGGCAGGTTGAGGGCTCCTTGTGGAGCCTCAGTGAACACACCTACCCAGAAACATCCCAGGAATG


GGTTCCCCTAGCCCCTCCTCTCTGAGGGGGCCAGTGGCCACAGCTGTGGCCAGTGGGGTTCCAGAGAAGCCACTTCAAGTGCCCCCT


TCTGGTCCCAAGAGGTTCGGAAGGGAGCTGGGCCAGAGGCTCAGGGACGCTGCCCATTTAGTCTCAGACATCCCATCATGGGGGCGG


TAACTCGAGTCTGGGCTCCCGGAGGACACTGAAGATGGAGGCCTGCTCCGTAGCCCTCTCAGGACTGGGTCATTCTGTTCCTCGCCA


GTGGGAGAGCAGTGGGGCCTGGTCCCGAGCGTGGCCACAGGGCCCAGCTGTCCCTGTGCTTCTGTCAAGGGCGGCACATTCTGTCCT


TCACGCAACAGCACCATCCCCTCAGCTCATCCCCCATCATGCCTGAAGGAACTATGTGGTGCAGGTTCCCACCCCCAGCCTGGAAGT


GTGGAGCCAGACCTGTCTCCTTTTACGTCAGATTCCATCTCCCTGCCTCCCTTTTTCCCCTCTCGTGGCCTGCATTTCTCTCTCCTT


CTTGGAGTCTCTGTTTTTGTCTTGCTCTTTCTCTTCTCTCTCCTCCTTCCTTCCCTCCTCCCCCTGCCATTCCTCTGACCCCTTTCC


TTCATCTCCATTTGGTTTCATCCTCCGTCCTTCCCTTCTTTCTTGCTCTGCCTCTAGCGCAGGACAGGGTCCATGTGATGTGAGAAC


CTCCACGCCAAGGCTTGGTTGGGACAGCCCAGGTCTCCCCGCAGGCAAGGAGACTGGAAGGGACGTGGGCCCAGCCACACCCTATAA


AGTGGCCATGCACTAAGGACCTGTCCAGAGTCTCCTCTCATATTCTGTTCCATGCTTCTTGCAAGGACTTTCCAACAGAGTGTCCCA


GGACAGGAGGAACTTAGGCCACCCAGCATGGAGGCCAGTGGACAGAGGCCAGACCGGCACTGTGGGGGTGCTTGGGCTGGAGGACCC


CAGGTACTTCCGGCTTGGAGACATCCTGGACCATCTCCCTGTGATGTTTCATGGGGCCTCAGAATGGAGACCTCACAGTCCCTCCAC


CTGTCCATCTAGAATATCTACATGCACCAAAGGCCCGCAACACTGCCAGCCCCGAAACATTCCTTCCTACCTTAATCCTCAGACACC


CCGAGGAAGGAACGGGTATAGGTGATTTCCCGTGCCTGTGGGCTACAGCCCAGGCTCTGAGCTTGGCACTCACAGCCTTCATAGTCT


TGCTGACTGGCTTGCCCTTGGGCCCACCCTGGCCATGTGCCCTGTTCACCCCCAACTCTTACTGTTGTGGGACACTTCTCATGCCTG


GGGTGATTGTGTAATGTATGATCACATCTGGGATGCTTTGGCGGGTGGAAGGAGACACTGAATAGTCAATTCCATGGCAACAAGCAC


AGGCCAGGACTGTCCGAGGCAAACCAGGGCATATGGGCACCCCATTCACCCCTCAGTGTCTTCCTTTCCCTTGGCCTGAGCTGTTGA


ACCCACCCTTCTTGTCTGGCAGCCTCTCCCTCCCAGCAAGCCCAAAATTGTCAGAGCATCTGTAGCTGCTTTGTGTTCTTAGGGCCT


TCTGTCAGCGGGTCCTCTCCCTGCAGGCTGCCTGCCCTCCCTGTCTCCCTACCCTCCTCAGCCCTGGCACACCCAGTTGGTGCTCAG


TGAGGCAGGGATTCAAATCTTTGAACCGGGAGTTGTTCTGGGGTGCTACCCCCATGGGTACTTTGAGGCCCAAAAGCCCTCCCTCTG


TCCTCCCTGGGCAAGGTCCCTTCCAGGCCAGGCCCTCTCCAGGTCAGAGTCCTTCACCATCCTGTCTCCCTTTCTCTCCCTCTCCCG


CGGTCAGTGGCGGCCAGAGGAGTCCGAGGACTATGTAAGTAACAGGTGTGCGAACGCGGACAAGACATGGGTCAAGCTGGGCTCGTG


GGACGCTCCTCCTCTCCCTCCTTTCCTGCTAGCCTGCACTGCCAAGATCCACAGGGCTCTAGCCACATCAGGAGAAAATTGGCCTTT


AGACACAAGCACTGAGCTGAGCAGCGATTGGCATTTCCTCTAATCCTTACTTCTTGCCTGTCGAGCAGCAATTTGAGGCCAGTGTTC


ATGATCGACCAGGGCCTGGCCCCTGCCCCGGCCAGACAGGGATGGAGTTAAATCCAATCCTGATCGTTAGGCCTTATTGATCCCTGG


AGTGAAAAATCACCTGCTTTAGGGCCCAGGCTGGGAGGGCTGTCTGGAGAGTCGGATTCTGGCATTGGTGCATTCTGGAGCCCCAGC


CCTGGGAGACCCTCCAGCTGTGGCAGGAGGGGTCCATGAGGGGGTGGTGGCAGCTGCAGGGGCCCCACTCAAGGCCAGAGCTGGAGG


GATACCAGGGTTGATGACGGCTCTGTTCCCACTGCACGGTGGTCCCTGCCCTGCTTCCCACTCTTCTCTCTGTGTGGTGTGGCTTGA


CCTCCCATGGTGTTTCTCCGCATGTCCAGAGATGATGCCTTTGCTGCAGATGGGTATATGGGCAGGGTCTGCCAAGCGGGGAGGACA


TTGCCCTGGCTGCTGTCTCAGGCATCACTGAGAACAGATGTGGAAGCCAGTTCCCCAGGTGTGGAGGTTTTCTTATTCTCCTAGCCC


CTCCCCTGCCTTTCTCAAGAGGTATTGCAGGGTATAGACATTCACAGAGTTAGTGGCCTATATGGGGGCAGCGGAGTCCTGACTGGG


TCCTATAGGATGGCACCTTAGCCCATCCTGCCACCTTGCTCTGTCTGTGCATGCATGCACTGGTGTCCACAGGCAGCCTTACGCCTG


CTTATGCAGGAGCTGTAGGCTGTGTGCGTGTGGCTGCCAAGAGCCACGCAAGGTGCTGGGTGCGTGCGAGGCTGTGCCCTGTTGATA


TCCTCAGTCTCCGTTCACAGCACAGTGGAGTGAGGGAAACAGTCTGGCCCTTTGTTCTTGTCTGAAAAGAATAATGAGCTGTCTGCC


CCAGGCGTGCGGCTCCTGGGATGGGCGGGGTCCTCCCAGGCCTGCATCCTACCTGCCTGCTTCCTCTCCAGCAGAGGCCACCATTGT


ATAGCCCCACCTTCCACAACCCCTGGCCTTGTGTGCCCCGGGGCTCCCCTCAGGCTAGGGTCCTGAGGTCCCTGACAAGGTCTGGCC


TCTCCCTGCATTCTTGTGATGGGAACGAACCCCTCCTCCTCCCTCAGGAAACCACTATCAGCGGCCTGACCCCGGAGACCACCTACT


CCGTTACTGTTGCTGCCTATACCACCAAGGGGGATGGTGCCCGCAGCAAGCCCAAAATTGTCACTACAACAGGTGCAGGTGAGTGAG


GGGTCAGGACGGACCTGAGGGTGGGGCAGCAGGAGGGCAGCGCCAGAGCCCAGCCCGTGGTCCTTCAGTCCCAGGCCGGCCCACCAT


GATGATCAGCACCACGGCCATGAACACTGCGCTGCTCCAGTGGCACCCACCCAAGGAACTGCCTGGCGAGCTGCTGGGCTACCGGCT


GCAGTACTGCCGGGCCGACGAGGCGCGGCCCAACACCATAGATTTCGGCAAGGATGACCAGCACTTCACAGTCACCGGCCTGCACAA


GGGGACCACCTACATCTTCCGGCTTGCTGCCAAGAACCGGGCTGGCTTGGGTGAGGAGTTCGAGAAGGAGATCAGGACCCCCGAGGA


CCTGCCCAGCGGCTTCCCCCAAAACCTGCATGTGACAGGACTGACCACGTCTACCACAGAACTGGCCTGGGACCCGCCAGTGCTGGC


GGAGAGGAACGGGCGCATCATCAGCTACACCGTGGTGTTCCGAGACATCAACAGCCAACAGGAGCTGCAGAACATCACGACAGACAC


CCGCTTTACCCTTACTGGCCTCAAGCCAGACACCACTTACGACATCAAGGTCCGCGCATGGACCAGCAAAGGCTCTGGCCCACTCAG


CCCCAGCATCCAGTCCCGGACCATGCCGGTGGAGCAAGGTGTGTGCTGTGGACATGGCATCCCTTCCCGAGTGTGGCTGCATCTGGG


GGTCTCTGCTCTCCTTGAGCCACTGACCTCTGGCGACTGTGATCCACCAGCCTCTGGTGTGTGACCTCCAATCTCTCATGACTGTGA


CCACTAACCTCTAGTGAATGGGCACCACATTCTTGATGCCTGACCTCTGCTGTCCTTAACCTACTGACCTCTGCTGTATGACCTTCT


GATCTCTTGTGACCTTGACCCACTGATCTCTTTTGACTGTGTCACTATTCTTGGGTGTGCAACCTCCTGATCTTTGGTGTGTGACAC


TAATCTCTTGGGGCCATGACCCACCGACCTCTAGTGAACATGCTCCACCACGCTCTGGTGTGTGGCCACATGCTTCTCATGACCGAA


ACCCACTGACCCTCTGATCACTCTGGCCTGGTGTCCATCGGCTCAAGCTTTTACACTCGCGTTTCTGGAGATTCTGACCCTGGTTGC


TGTGGCATCCCCCGCCCTGTTTGGTGCTCACTGTGGAAGAGCTTCGGCTGGGAGTTCAACTGTGCCGTTTGAAGCTGGCTGGGAGTG


GGGCGCTTGGTACTCTGCAGCCATCCTTCAACCCCCTGTTCCCCAACCAGTGTCTCATCCTGGCCATTCACCTTCCACCCTTCCACC


CCATTCACCCCACCTCATATACCCAGCAGAGCTGACTCTCTCTATGCCTTTGCAGTGTTTGCCAAGAACTTCCGGGTGGCGGCTGCA


ATGAAGACGTCTGTGCTGCTCAGCTGGGAGGTTCCCGACTCCTATAAGTCAGCTGTGCCCTTTAAGGTGAGTAAGGGCCACGGCCAG


CTGAGCCTGGCACAACACAGGCCTGCTGGGTGCTGTCTTTCCAGTCCTAACCCATGTGCATCCGGCTGTGGAGCAGGAATGTGGTTT


GTGTATCCGTGCACTGTGCCTTGCAGCCCGTGGTAGGGAACCTCACCCAAAGGCATTGATTGCCCCTCCCGTCCCCCACAGATTCTG


TACAATGGGCAGAGTGTGGAGGTGGACGGGCACTCGATGCGGAAGCTGATCGCAGACCTGCAGCCCAACACAGAGTACTCGTTTGTG


CTGATGAACCGTGGCAGCAGCGCAGGGGGCCTGCAGCACCTGGTGTCCATCCGCACAGCCCCCGACCTCCTGCCTCACAAGCCGCTG


CCTGCCTCTGCCTACATAGAGGACGGCCGCTTCGATCTCTCCATGCCCCATGTGCAAGACCCCTCGCTTGTCAGGTGTGCACACGAG


GTATCGGGGGAGGCGGGGCAGGGCTGGAGGTAACCAGCAGTGACAGTCCTGATTCCTGCCCTGCCCACCCAGGTGGTTCTACATTGT


TGTGGTACCCATTGACCGTGTGGGCGGGAGCATGCTGACGCCAAGGTGGAGCACACCCGAGGAACTGGAGCTGGACGAGGTACCTGG


GGAGGGGATGGGGACACTGACAGCCCCATTGCAGTGGTCAGCTGTGGCCTTCCTGCCCTGAGCACTGTCCCAGTGACTCTCAGATTC


ACTCCCCAAATTGAAATCTCTCTTCTGGCTGGCAGCCCGCCCCTCTCTGGAGAGAGGGACTCTGAGGAAACCATCTGGGAGTATTCA


CAGAACTCCCGGAGGGCTTACGAAGAATCCCTGGGGTGGGATGTCGTGGAGATGCCTCTGCAGGTCTAGAGAATGCCAAGCCCTGTA


GACACTGCAGAGCCTCGCAGATCTAGAAGCTATGGAGGGCTTAGTGAGCCTTATAGCCAGGAGTCCCTGAATGTTTGAAATCCTTCA


GTCCTTTCTCATAGCCAGTGTGGCAACAGCCTGGTTAGGGTGGGGCAGCTTACACACAGGGCTGCTTCTCATGGGCTGGTGGGGAGG


AGTGGCTTCACGGTGTCTGTTACTCTGTAGGGGCAGTGGGTTGGGCAGGTGTGGGCTCTTACACGGAAGGTGAGCCTTGATCTCGGC


CCAGGGAGCTGACATCCCAGGCCACAGCCCCAGGGCTGGCCGGCATGCTCCAAGGCCCCTCATGACCCCCATGCTCTGCTCTGCCAG


CTTCTAGAAGCCATCGAGCAAGGCGGAGAGGAGCAGCGGCGGCGGCGGCGGCAGGCAGAACGTCTGAAGCCATATGTGGCTGCTCAA


CTGGATGTGCTCCCGGAGACCTTTACCTTGGGGGACAAGAAGAACTACCGGGGCTTCTACAACCGGCCCCTGTCTCCGGACTTGAGC


TACCAGTGCTTTGTGCTTGCCTCCTTGAAGGAACCCATGGACCAGGTCTGCCTGAGCCGGCTTGGCTGTCAGCACCCTGATTCCCTG


GGCCTGGCCTGAGACCATGCCAGTCTCAAACACCACAAGACCCCAGGTCTTTATCAGTTTGGGGGCTTCGAGATCCTGGGGCAGCAC


TAAAGACCCAAGATCTGTCCCGGGGATCCTAAGACGCGGCCCTGGGACCCAGAGGCCAGACCTAATGTGGCTCCAGGGACCCAGTCC


TGCCAGGTCCACCTTGTAGGGTCTGGGAGACCAGGCCCAGGGTAACCCAGACCCAGAGCCCTTTCTCCAGGATTGATAGGCAGAGGG


TGGGGGGTTCTCACGCTGAGCTCACAGCCTGCTGTTCTCCACCGGGCCACAGAAGCGCTATGCCTCCAGCCCCTACTCGGATGAGAT


CGTGGTCCAGGTGACACCAGCCCAGCAGCAGGAGGAGCCGGAGATGCTGTGGGTGACGGGTCCCGTGCTGGCAGTCATCCTCATCAT


CCTCATTGTCATCGCCATCCTCTTGTTCAAAAGGTGAGCACTGCCCTCAGAGCTCCGGGAACGGCCACCTGCCCCTCGCCTTTCAGG


CCCTCTCCGGGTGTGGTGCCTGTGGAGAGCGTGCAGCCTTGCATCCTGGACCCTGAGCCTCAGGCTCAGCAGGAAGGCAGGAAGGGC


AGGAGCAGTGTGTGTGCCTACCTGTGTCTGCAGGCCTGCATCTGTCAGGTGAGGGAGCCTCTGCAGCAGCCTGGGCGTGAGGAACTA


AAGCCTCAGAGGGTTGTCTCATGTGCATCCCTGGCACGTCTGTCTGTCTCTGTGTTTCTGTGGATAAGAGTGCGTCTGTCTCCTCTT


CAGTTTTAAGACACCGCCATCTCCTGAGCTCCTACCTCGAGTCCTTTCCTTCTGCCACCATTCCTGGATGATTCCCCAGCCCTACTC


TCCTGCTTAGGCCTAGAGAGGTCGAGCTGGAGGCCCACAGGCCATGGATGCTCACTAACAGACATGACTGATGGCCTGCTGTGCCCG


TGCCATCCGCAGCGGCCTCAGCCTCAGTGTGTCTTTCCCACTCAGTTCTCTATCGGCAGTGGCCACCACCTGCCCTAGGAGTCTCCC


TTCCTATCCGTGCACCTTCCAGCCTGAAAGGGATTTCCAAAGATTTAACTTTGTCACTCTCAGTTTAAAACCTTTTGATGGCTGCCC


ACGTAAAGCCCACCCTCTTTAGCCTGACAGCCAAACACCTGGCTAATCTGACCCCTGCCACACTCCTGACATTGCGACACTGAACTC


ATTCAGTGTTCAGGCCCACACAGGGTGTGCCCTCTGCGGATCTCCCTCCCCCTGCCCACTTGGCAACAGCAATCTCATCGTTCAGGA


CTCAAGTCCATGCTCTGGTGCCTGCAAGGCCTTGCCTGGCCCCTACCCCTTCCTTGCACAGCTGTCCCCTGTGATGCTCCACTGCAA


ACGCAGCTGGGCCTGTGTGCCAAGCCTTCAGCCCCCAGCACTGGGCTGAGCCCACAGGCATGTCAGTGAGCACCTGGCAGATGAAGA


TATGCTAGTCTGTGTGTCTGAGCACATCTCTGCACCATGCAGGAGAGCCTGTATCCTGTGTGCCTACCCTGGACCCACTGTTCCTTC


CTAAAGAGTCCACTCCTTCCTCCCAGGGTGGATGGACCTGTGGGCGGGTCCCTAAGGAGTGTCCCACAGATGCACTCATCCTTCCCA


CTTCCACCTGCATTCTGGGTCTGTCCAGAGAGGTAGACCCCCTCCCTGTGAATGTCATGTGGGTGCCATATAAGGGGCCTGCAGGGT


CCCCATGTCATTAGAGGGCTGAGTGCTTGGTGGAAACTGTGACCGTTCCTTTCTTCTGTCCTTGCTTGTCTTTCGGGACCTAGTAAA


CAAGAAAGGTAGGAGTTGTTCCTTCTCTCTTCACACACCTCCCCCTCTACTTCTAATCCTTGGGCCAGCAGGGAGGGATGACGCTTT


GACCAGAAGTCCCCTGGCCTATGGCTTTAAGCAGCAAACTGTCCAGTCAGCTCAGCAGGCTCCCTGGTTCAGGACTGAGTCCTCATT


GGTGTGAGGAGGCAGTTTCTGTCTCACTCTTGCCAGTTCAACTCTGCAGAGGATGCTTCTTCTCTGGGGCACATACATAATACAGAC


TGCATTGCTTTCCCTGAGCGTACAGAGCTCACCAGAACCATCACCCGGCTCCCAGTTCTCTGAGAAGTTGCCTAAGTGCTGCGAGAG


ACAGTCTCGCACAGAGCAAAGAGCAGTCACTGTGTGGAACAGCAGAGAGGCATGTCCTTGTACCCACCTGAGCACACTCACTCAAAT


TCTTCTTCCCGAAGCACATGCGTCTGCAGACCACAAGTAGCCTCTGGCTATTTGTTGGCAGCTGAATCCTATGGTCTGTCTCTGACC


CTGTCCTTGTAGATGGGAAAACTGAGGCCAGTGAGAGAGGACTCTGCCCAGCTAGGGTGACGCCTTTCCCGTCCCTCCCCTGCTGCC


CTGGGCATTTACCCTGATACTCTGAGGGCCAAAAAGCTGGGGCCCTGTCTCCTGTGCTGTTTGTGTATTTTATGTGTCATTTGCATG


TTTGTTCCCGGTGGTTCCTGCTACTCAGCTGGGTGGCCTTGGAGATAGCAGTCACTGTCCTGCAGTGACCTGCCTTCTATCCAAAGG


AGCTGCTCGCCCCTGCAACCCCTTCCTCCCTGCTGCACTGCCCCTCTGCTCACGCCACACTCCTGCTCTCCCTACCCCCTCCCTGCC


CTGTGTTCTCTCATGTCAAGGCTGTTCTGGCCCTGGCTCCTCCGCGCTCAGAGATCCTGGGAAGAGGTGGGGCAGTAGGAGGACAGA


GCCGTGGACATGGGGGCTCCTTGGCAGCCAGCCATGCCATGTGTCACTGTCTCAGCCTGGACCTCAGGTTCTCACCAGCCTCCCTTC


TGTCTCTCTAGGAAAAGGACCCACTCTCCGTCCTCTAAGGATGAGCAGTCGATCGGACTGAAGGACTCCTTGCTGGCCCACTCCTCT


GACCCTGTGGAGATGCGGAGGCTCAACTACCAGACCCCAGGTAGGGCACTCCTATGGCCTGTGTGCCCCCAGCCCAGACCTAGCAGG


CCTGTGGGTCCGTTCTGCAGGTCTCAGGGTCGCCACTGAAGTTCCTGGGCCGCATGCACTTGTTCCTGCTCCTTTTCTTCCTTTCTG


CCCTTCTCCCTGTGCTCATCCACTTTGGTTGGAATGACTGGGGAGCCCCCATATCCTGCAGCTGGACAGGTGCCCCAGGCCAGGACC


CTCTTAGGTGGCAAAGCCACTTAGCCACTGCCTTGTCTTCAGTCAAGGCCTCTGAATATGGGCTGAGGACCTCCCAGAGCCCACGTC


TCTGCCACAGGGTGGCCAGTGTCTGGCCCACGCTCTGACGCCTCCACATGAAAGAGGGGCATGTTAGCAGTGGGAGATGCCTCACCA


GACATCTGTGGGGAGATGAAGTGCCTGCACCTGAGCCTTCCTGGAGGCCGACCCCAGGTTTACCATACCACGTACCTGCCCCTTCTC


CTAGCCACTCTCATGGGGCTGTCCACCTCTTCCTTCTACCTGAAATGTTACTCCTCCCAACACCCAGCAGACACAGCTCAGACCTCT


CCTCTTGCCCACACCCCCACAGGGTTAGGTGTCTCTTCTTGGCTCCAGGAACCTCCCTCCTTCTTCCTTTTGACGCCTCTCACAGTG


AGCTGGGATTACCTCAGTGACAGTCTCTGAGCTCTGTGGTGCCAGGAACTGTGTCTTGTCATCCCCCATCCCTTGTATTCAGCGCAC


GATGGGTTCTTGTTGAATGCCTGTGAAATGAACACACAGACAAATGAAGGAATGAGTGAACTAATGCATACACACAGGGTTTGTGTA


TGTATGAGCTGGTTATTCTGCATGTCAAATTACCCCAAACTTAGTGGCTTAAAACAACAATAATTATGTATTATCTGTCACAGTTTT


TTGTGAGGCAGGAATTCAGACAGGGGCACAGCAGGAACAGCTTGTCTTTATTCCAGAAAGTCTGGGCCCTCAGCCGGAAGACTTGAA


GGCTGGGAGCTAGAGTCATTTAAAGCAGGGGTTGGCAGACTATGGCCCGTGGCCAAGTACAGCCCACCACCTGTTTTTGTAAATAAA


TTTTTACTGGCTGGGCGTGGTGGCTCATGCCTGTGATCCCAGCACTTTGGGAGGCTGAGCCGGGTGGATCACCTGAGGTCAGGAGTT


CGAGACCAGCTAATGAAATCCCATCTCTACTAAAAGTACAAAAATTAGCCAGGTGTGTGGCCCCTGTCATCCCAGCTACTCAGGAGG


CTGAGGCAGGAGAATCACTTGAACCCAGGAGGTAAAGGTTGCGTGAGCCAAGATCGTACCATCGCATTCCAGCCTGGGTGACAAGAG


CAAAACCCCATCTCAAAAATAAACAAATAAATAAAATTCTACTGGAACAGACACACCCATTTATTTATATGCTACCTACCTATGGTT


GCTTTTGCACTGTAAAGGCACCATTAAATAGATGCAGTAGATACCAGATGTCCACAAAGCCTAAACTATTTACGCTCTGGCCTGTTA


TGGATACCAAGTTTGCCAACCCCTGGACTCTAAAGCCTCTTTCATCCATGTGACTGGTGGTTGATGAGCCAGCTCTGAGCCTTGCTG


TGGCTGTCAGCTGGGACACCCAACATGAGGCTTCTTCAGGTGGCCTGGGCTTCCTCACAACATGGTGACTGAGTTTCATGAGCATGT


GTCTGGAGAGTGTGCCAGGCAGACCTAGCAGGCTGTTGCAACCCAGCATGATTAGATCTCTGAAGAATCAAGCACCAGGATGCTGGG


ACCTGGAGTGCAGAGAAGCCTCTTCGGGGATGGGATGCTGAGCCATGTGGTTATTGGTCTGGAAAAGAAGGATGGGAGAGAGCTCCT


CAGTGGAAGCATGTGCAGAAGCTTGGGCAGATTGCATGTGCGTCAAATTATGAGCACCTGAGGGTTTCTGCAGCATGAGAGTTAGGG


GCTTGGGGAATACTGAGCCAAGAGAAGACTGGAGGGCTAGGCAGAGGTCCAGTCAAAAGGACCTTGAATGTCAGGCTAAGGGGCTTA


GACTTCCTCTTCAGGATGCCAGGGAGGTAGGTATTAAAGGTTTTCAGCGGGGGAGCCAGGTGGTCAGAACCATGCTTTAGAAATGTC


ACTCTGGCTCCTTGAGGAGACTGGATTAGAGAGGAGAAATTGAGGCAGGGAGACCATTTAAAAGGCCAGCAACCAAGTGAAAGGTGG


CAGTGGGAACAGAGGGGACAGACTTGGGAAACGTGAACGAGCTGAGGACAGCAGAGTCCGGGCTTAAGCCCACTTGGGGAGAGGTAA


GGGTGGCTCTGCAGTTGCTGGCTGAATGAGCAGGGGGTAGGGGTGTCCTGGGGCTGGTGGGTCTGTCGGTCTGAGGACTTCTGAGCT


GACATCAGGGCTGAAGCCCTGTGGGAGGGGCCAAGGAGCATGTGGTAGTCAAAGCCTGAGAATAGATGGGCTCTCCCAGGGTGAGGG


CCAGAAGGAGACCGGGACCAAAAAGCCCAGGGCAGGGAAGGTGGTGCAGCATTAAGGAAAGATGGATGGAGAGCACCTAGGGAGATT


GAGAAGGAGCAGCCACAGCCAGACGAGAGCAGGAGCGCAGTGTCCCTGATGCCAGGGTTGGGGGAGTTGTGCAAGGGACGAGAGGAC


TTAATGAGGTAGGGCAGTGGGGACACCCAGTGGGAGGACCGTTGGCTTTGGCAGATGGGGCCTTGAAGAGAGGGTGGTGGCCACGTC


CTGTGGGCAGAAGTGTTGCAGTGAGCAGCGTGGCAAGTGGGGGCTGAGAAAGTGGAGAAACCCCTTTCAAAGATCCTGGGAAGATAC


CTGGGAAGGAGGCAATGAGCAGGGCACAGTCGGAGAGTAGAGGGTGTGGGATCTGAGAAGGAGGGCTCTTTTTTCCAACGTGGAAAT


CATCTGAAAATCGCCAAGGGCAAATTTTGGTATCAAAAGGGGCACGGCTGGTTTGGACTTAAGTATTTAGTCATAGAGCCCCCCAAG


GCTGCCGAGCCACCAGGGTTTAGAAGTGCTCGCCTCTGGGGGTGGGACACCCAGTCTGTATTAACTGGGAGACAGAAGGAGCCTTGA


CGGAACTTGTCCGCAGCCCCAGCCCCTCACCGCCCCCTCCTCTTCTCCGCCAGCCCCTCGCAAGCCCGCTCGGCACCTCCACTGTGT


GTGATGGTGCTGTAAGCAGAAAAAGTTAACGGGCTCTCTTTTCTTGCCCCGTTGTTTTTTTCGTTTGTTTGTTTGTTTTTTTCTCTG


CAGGTTCCAGTGTCCCCAGTTGCCCGAATACCTCAAGTTAGTTTTCAAAGTTCCCGTGTTTGGGGGATACTTTGGCTTCTGTGTCTG


TTTCCACTCCTTACTTTTGTTTACCCCATCGCCTCCATCCTTCCTTGAATTCTTCTCTCCCCTTCCCTTTCTTCTCCCCCAATCCCA


CTGTCTCCTAACCTTTTTCCTTCCCTACCCTCCCCTCTGCCCACCTTGCTTCCTCCAGGCCTGTTTTCTCTCCCACCGGCCCCGTCT


CTGTTCTGCCTCTCTGGCCTCCAGTCCCGGCCTGACACCCTTCCTTCTGCGTGCCTCTACCTCTCATCTCCTCTCCTCTGTCTCACA


CCCCCCTCCTGGTCTCTGCTTCTCTCTCTATTGTGTCTGTACTTCATGACCACTCCATCTACACACTTGGTGCCCGGGATGACGATG


GCTGTGAGTCTCCCATGGTGACTGCCACCGGTGAGGGGCAGGAGGGCTGTCTGCAGGCAGATGCGATGGAGCCCAGCTCCTGTCACG


TCTGCTGCCACCGACCTGGGCGTCCCACCCCTCCTGGGAGGAAGGAAGCCTCTCTTCCATCTTGAGAGACCTGCCAGGCAGGGCCTA


GTGCCCCCACTCAGCACCCCGCCACCAAAACAGGCTCCACATGCTCATGGCACAACACCGCCCTCTGTCCTCTCCCACCCTCCGCCA


TCCCTGTCGCCGCATGTGCTGCTGTCTCCATGCCACCAGTTCCAAGTGCTCCATGGTCACACATGTTCACATGTGCACATACATGCG


TTGGGGCTTTCTCTGCCACACTGCTCAAGCCTCACACTAATGCTGCCTGTGTATGCCCTACCTCCCCTAGGTATGCGAGACCACCCA


CCCATCCCCATCACCGACCTGGCGGACAACATCGAGCGCCTCAAAGCCAACGATGGCCTCAAGTTCTCCCAGGAGTATGAGGTGAGA


TGTTCCCGCCCCCTACCATGTGCCTGGCCCAGGCCTACCCAAACCAGCTCCTGTCCTGTCCTAGGTCCCAGCTGTGGTGGGTGAGGA


AGCAGGGGTCCAGCTTTTTCAGGAGCACAGAGAGGAGGGTTGGCAGGGGTAAGGGTCAGCTGGGAACCGGGTGCCTCAGATGCTGGG


TCTGGCCATAGCCTGGCCCAGCACCTTCTTGGGGTCACCCTTAGGAGATGGTTTCAAAAGGCTGTGAGTGACACCAGGGTCTGGACA


CTCAGACACGTGCTCAAGTGCTCACAGGCAGACACAAGGCCACAGGCATACAGACATAGATCAGTGATAACAGCCACAGTAGCTGGC


ATCTATCAAGAGCATCCTGCAGGCCAGCACCGGTCTGGGCACTTGGCATGCATTATCTCTTTTGGTTCCCCCACAGTCTTCAGAAAT


GGGGACTGTTATTATCCCATCTTCCAGGTGAGGAAGCGGGGGCTCAGAGAGGGGAAGTGACTTGCCCAAGTCAAACAGCTGATGAGT


AGTGGAGCCAGGATTCAAACCCAGGCCTGCCTGCTGCCCTGTGCTCTGCACATGCATGTGCTCACGTGTGTACTCCGATGCCACAGC


TCACGGGGAGTCGGGGCCTCGAGACTGGCTGCTCAGGCTGTACAAGTCCCGCTTGGAGCCCTCCACACGTTCATCTTGTTCTGGACT


TAACTCCTAGGAGCCTGCTGGGGGCTGAGCCTTCAAGAGTCTGAGGGTTTCCCACCCACAGATGGTGTCGGGGTGACTCTGAGCATC


CCCAGGCTGCCCATCTAGGAAGGGGATTTGTTAGAGAAGGAGGTGATTTAAAGACAAGACTCCTGGCCAGGCGCAGTCGCTCACGCC


TGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACCTGAGGTCGAGAGTTTGAGACCAGCCTGGCCACCGTGGCGAAACTG


CATCTCTACTATAAATACAAAAATTAGCCAGCTGTGGTGGCACATGCCTGTAGTCCCAGCTATTTGTGAGGGCTGAGGCAGGAGAAT


CGTTTGAACCCGGGAGGCGGAGGTTGCGTTGAGCCAAGGTCATGCCATTGCGCTCCAGCCTGGGTGACAGAGTGAGACTCCCTCTCA


AAAAATATAAAATAAAAAAAACTCTTAAAAAAGAGTATTTTTACTTAAAAAAGAGAGAGAGAGACCTCCTCCTCTTCCACCTCCTCC


AAGCAGCAGCCTGTGCTTGTCGTTCTGCCTTGTCCACAGCTGTTTCCTCAGCACCTGGCACTGGCCTCAGTAGATGGTTGGTGGACA


GGCAATTGAGGGGTTGGCTGAGCCTAACCTGTGAGTTTGCGCCCCTTCTGATGTCCACCCTCAGCTGTGTTTGGGGGATGCATCCTA


GGGCTCAAAGATTGCCTTTCCCAAGGGCTGTGGGCCAGGTTTCTGAAGAGAAAGCTGGGCTTGGCAGGCAAATGGATGAGTATGTCT


GCGGCACAGCAACCGTGCTGCCTCTGCCTATAGGGCCCCCCTGGGGCCCTGCTCCACACAAGGCTGGGCTTTGGGTCACGGAGCCCG


TAAGGTGGGCTCCCTGCCTCCCATGGCCTCCACCCACACTCATCTGTACCATGTCCTACACCTGCCCTTCCTTCCAGCGCAGCCCTG


CTTCCCCATCTGGGCTCGTGGGGCCTCTGTTCACAGTAGTCCCCTTCCATCTTCTACCTGCTTCCCTCCTCTGATCAGAGCTTTCCT


TACAAGACCCTCCTCCTCCAGGAAGCCTTCTCAGGCTCCCCAAGGCTGCCGTGGGCTCTCCCTCAGCCAGGACCCCATAGCTCTGTT


GTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCTTTTTTGGAAGTCTCGCTCCGTCATCCAGGCTGGAGTGCAGTGGCGTGATCTC


GGCTCAGTGCAAGCTCTGCCTCCTGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTGCCCGCCACCA


CACCCGGCTAATTTTTTTTATTTTTAGTAGAGATGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCG


CCCACCTTGGCCTCCCAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCAGGCCTGCTCTGTTGTCTTTAACGTTCAGTCAGTCAT


TGATCACACATTTTCCATGTGCCAGTCCCCGTGCTGGGGATGTGGAGACACATGCCCTCAGGGAACCCAGTCGTGGGGAGCATGTGC


AGACAGATAATCAGCATTGAATATGTGACTCTGACAGCATGCCCTGGTGTTGAATAGGACCGACAGGCGTGCAAAAGGTGGGCTGAC


AGCACCAGAGCAGCCTGAGGGGTGGGGTGTGCTGCGGGGTCTCACGGAAGCAGTGACGCGGTCCTGTGGAGAGTAATGAGGCTGGGG


ACAACATATGGAGGACATTGCGTGCTATGCTGAGAACTTCAGATCGTATCCATCTGGAAAATGTGAAGATAATAATGGAACCTATCT


CGTATGAGAATTTGAGGAGGGAATACATGCAAAGTGCTCACAGCGGTGCCAGGCACACTGTGGGTCCTCACTAACGCTTCGCTATTA


TCATTATTGCTCTCCGAGGTGAAGAAGAGCCACAGAAGGCCTTTAAGCAGGAAATTGATATTCACATCTGCATTTTGGAAGGATTAT


TCTGGCTGTGGGGCTGAGTGGGTCACAGTGGGACAAGAGGAAAGAGGCAGGAAGAGGCTGAGCCTCAATTGGGGTGGCCTGGCCCAG


GGCAGTGGCAGCAGGTTGGAGAGAGCTGAGGGGGTGGGGAAGCACCAGAACCTGGTGACTGGCAGGGCGGGGTTGGTGGAGGCCGGA


GGAATTTTGAGCTTGACTTCTAGGTTCTGGCCTGGCACTGAGGGGTGAGGGTGCCTTTCGCTAAGGTGTAGTCCCAGCAGCAGCGCC


AGGTTTGGAGGGGAAGCTGATGAACTCAGCTTTGAAAGGACTGCGGTTGAAGGACCTCCCGGTGGAGGTGTCAGAGAGGCTGCTGGG


TACTCGGGGAAGAGCTCTGTGCTCCTGCTGAGGTTATGGGCAGCTCCAGCATGTGGTGTAAGAATCAGGTGAGCAAATGAGGTCACC


CAGGAAAGGTTGTAGAGAGAGAAGAGGGCCTAGAAGGAACCCTGGAGGAGCTCTGCGTCCTGCCCACGGGAAGGGCAGGGGAGAGAG


AGGAAACAGAGAAGGAGCAGCTGAAAGGAAGAGAGCCGAGCAGGGAGGGATCCTGGACTACCTGAGAGGGGCCACCATCCCTTCCAT


CTGTCCTGGCTCATTTCATTAGGTGAATGCAGGGCTTCGGGAGGGACTCTGGGTGTTCAGAGCCCTCAGCAGTTTCGGGACTGCCTG


AGAGGGGGCCACCACCTGTCCTAGCTCATTTCATTAGGTGAGTGCAGGGCTTCGAGAGACCCTTCACCTGCCCCATCCCAGCTCAGA


CCACTCTACCAGGCAAGGGGATTTGGTACCATGGTCAGAGGAGTCCCCAGTCCATCACTTTTCTGATAGGTGATGTGGCAACCTGTG


AGCTCCATGGCTGGCACCACGAGATAGAGGGCCTGGCTGTGGCCTGTGGAGTGAAGCCAGGATGTGAGCATCACCGGGAAGGCTGGG


TCCCCTGCAGGAGAAGCAGGTCAACCTTGGCTCTTACCCCACCCCACCCGCTTTCTCCATTCTCTGCAGTCCATCGACCCTGGACAG


CAGTTCACGTGGGAGAATTCAAACCTGGAGGTGAACAAGCCCAAGAACCGCTATGCGAATGTCATCGCCTACGACCACTCTCGAGTC


ATCCTTACCTCTATCGATGGTGAGCCAAGGGGGTGCCCCTCCCATCCCCTTGCTCTCCCCCTTGCTAGCTAGGGCAACATGTCATTC


TACAGAGGATGTCCACGAGTCTCAGGGGTGCACTGAGGCATGGTGGGCTGGGCTGGGGACCCTGTAGTAATGCCCTCCCACCTCCTT


TCTTATCCATAGGCGTCCCCGGGAGTGACTACATCAATGCCAACTACATCGATGGCTACCGCAAGCAGAATGCCTACATCGCCACGC


AGGGCCCCCTGCCCGAGACCATGGGCGATTTCTGGAGAATGGTGTGGGAACAGCGCACGGCCACTGTGGTCATGATGACACGGCTGG


AGGAGAAGTCCCGGGTGAGGCTGCAGGGCCCTGCCAGGAGGCGGGTGGGAAATGCCCAGCCACAAGGTGATACAGGGCACCTTCTTC


TGTGCCGCTTTCTTCTGTGGACGAAGTCGCTCAAGTGATCCCCAGATGCTATTGTTACTGGGGGTATTATGCTCCCCAAATACTGGG


TGTTTCTGGGATACAGCATGTTCCCCACATGCTAGTGGGTTCCTTAAGATGTTAATATGTTTCACCAAATGCTGTCATTTTCGGAGA


ATGTTAATGTGTTCCCCAGTTGCTGGCGTGTTCCCGGGGTATTCGTGTGTTCCCCAGATGCTGGAGTGTTCCTGGGGCATTAACACA


TCTCCTAAGTTAATTAGTGGAAAGAGCTGCTGTTATCTGTTTTTGGACTGCAAAGCATTGACTGGAACGTAAAATTTACAGAGCTTG


AAAATGGCACATAAACGTTATGGGTAAATTTGGCAGAAAATGTGCCTGGTGCGATCTGGCGTTGAATAAATAATTTTCAATTATGAC


CCTTATTCCACTAGCTAGGGCAGGGCGGTGACATAGCTTGAGGACCTGATGTGGCTTGTGGAGCACAGGGGGCAATGGATCTGAGAG


CTCAGGGCTGGGGGGCTTTGTAGCCAGAAAGGCTACAGCCAGGGAGTTGACCAGCCTCCACCCTGCTTCTGCCCGTCTGAGCCTGTG


GGCTTCCTTCAGCCTGCCCTGCTCATCCTCCTGCAGGTAAAATGTGATCAGTACTGGCCAGCCCGTGGCACCGAGACCTGTGGCCTT


ATTCAGGTGACCCTGTTGGACACAGTGGAGCTGGCCACATACACTGTGCGCACCTTCGCACTCCACAAGGTATAGCCTTTCCCCAGT


GCATATCTCTTACCCAGACACTGTAAGGACAGTGGCCTGGGTGTGGTGTGCTGGGTCGGGGGGAAGCTGGAGCCTGGGTGTTGGAGG


GTCGGAGGCTCAGGTGTGTGAGTGATGTGATGATCCATGTTATGGGAACAGTGCTAGGAGCTTCAGGCTACTCTGTGTGGCTTCTGA


GTCCCATGGGGAAGTGGCGGGTATGGCCTCAGCATCAGGTCATTCAGTCCTGAGTCTATGGCAGGTAGGCTCCTAGTCGCCAGTATG


TCCCCACTTTGTCCCCCAGAGTGGCTCCAGTGAGAAGCGTGAGCTGCGTCAGTTTCAGTTCATGGCCTGGCCAGACCATGGAGTTCC


TGAGTACCCAACTCCCATCCTGGCCTTCCTACGACGGGTCAAGGCCTGCAACCCCCTAGACGCAGGGCCCATGGTGGTGCACTGCAG


GTGAGAGGGTACAGTGCCACCCAGAGGGGTGGGTGGGGTGGGAGGTGGGGGCGCCTGTGCCTCAAGCTGAGCCCGTGTCCTGCAGCG


CGGGCGTGGGCCGCACCGGCTGCTTCATCGTGATTGATGCCATGTTGGACCGGATGAAGCACGAGAAGACGGTGGACATCTATGGCC


ACGTGACCTGCATGCCATCACAGAGGAACTACATGGTGCAGACGGAGGACCAGTACGTGTTCATCCATGAGGCGCTGCTGGAGGCTG


CCACGTGCGGCCACACAGAGGTGCCTGCCCGCAACCTGTATGCCCACATCCAGAAGCTGGGCCAAGTGCCTCCAGGGGAGAGTGTGA


CCGCCATGGAGCTCGAGTTCAAGGTGGGGCTCCGGTGGGCCTGCTTGGCTCCAGGGCCTAGACTGGGTCATGCAGATGACCCCCACC


CCCACAGGAAGCCTGGCCTGACCAATCCCTGCCTCTCAATAGTTGCTGGCCAGCTCCAAGGCCCACACGTCCCGCTTCATCAGCGCC


AACCTGCCCTGCAACAAGTTCAAGAACCGGCTGGTGAACATCATGCCCTACGAATTGACCCGTGTGTGTCTGCAGCCCATCCGTGGT


GTGGAGGGCTCTGACTACATCAATGCCAGCTTCCTGGATGGTTATAGGTCAGCATGCATGTCACTGCCCCACCATGCCCTACAGGGG


CCTAGCCCTGTGCCTGGCTGGTGGGGGTGGGCAGCAGAGTAGGGCCAGCCTAGAAGACCAGAGAGGGCTGGGTAGAGCAGTGAGGAC


TTCCTGGAGGAGGGGTGATCTGAGCAGGGCCCCAAGGGGCTAGGCAGCCTAAGGGGAGACTCTAGGGGCAGCAGCACCTCCAGCATG


TCCAGTCTTATGTCCACCCCAGACAGCAGAAGGCCTACATAGCTACACAGGGGCCTCTGGCAGAGAGCACCGAGGACTTCTGGCGCA


TGCTATCGGAGCACAATTCCACCATCATCGTCATGCTGACCAAGCTTCGGGAGATGGGCAGGGTGAGCCCACCCTTTCCCCCAGGGC


CCCTGTCATACCTGGGAGAACACCAGCCACCCTTGGGGGAGCTGCCGCCTATGTTACTGTCTCCTTTGACACCCCAGCTGCTTGTCA


GCATGGCCTCAGGCGCCCGTTATTACTACCTGAGGCATCTGTCCCAGAATCCTGTGAAGCCTGGCACCCCTCCCCCATTCCTTCTCA


CCTGATTATGGGGGCCCGACCCTCTGTCCACAGGAGAAATGCCACCAGTACTGGCCAGCAGAGCGCTCTGCTCGCTACCAGTACTTT


GTTGTTGACCCGATGGCTGAGTACAACATGCCCCAGTATATCCTGCGTGAGTTCAAGGTCACGGATGCCCGGGTGAGTGAGTGCATT


GAGTGTGTCCATAACGCTGCCTGTCCACACGCTGGGTGGATGGCTGCCTGCATGGTACCTTAGCTCAAGCTTCAGAAATCTGAGGCG


GTGGGTGGGTATTAGGGTGTGAGCACATCTCCCCCTGTGGCCTCGGGTGCAGTGACACAGATGCATGCCTGTATCATGGTACTACCC


TGGTCTAGTCCAGAGGGGTGGCTGCCTAAGGCACGAATTCTAATCATGTACCCCACCCACCTTTCCCAGGATGGGCAGTCAAGGACA


ATCCGGCAGTTCCAGTTCACAGACTGGCCAGAGCAGGGCGTGCCCAAGACAGGCGAGGGATTCATTGACTTCATCGGGCAGGTGCAT


AAGACCAAGGAGCAGTTTGGACAGGATGGGCCTATCACGGTGCACTGCAGGTGGGACTGGCCCCCTGGAGGGCTGGGGTGGGTGGGC


CTGAAGGCCTGGCAGACCCACTGCATGAGGCAAGCAGGACTCCTGACCCAACTGTGTTTCTGAGCAGTGCTGGCGTGGGCCGCACCG


GGGTGTTCATCACTCTGAGCATCGTCCTGGAGCGCATGCGCTACGAGGGCGTGGTCGACATGTTTCAGACCGTGAAGACCCTGCGTA


CACAGCGTCCTGCCATGGTGCAGACAGAGGTAACGCAGACCAGGCTGCAGGGCCAGGGCCTTGGCAGCAGCGCTGCTGGGAACCCTA


GGCTTTAGCAACAGTTTGATGCCCACAGGCATGTGCATTCATTCATGCTGCCAACCTTTCACGTGGCCTGCGATAGGCATGGTGGTG


TGTGCTTATGGTCCTACCTACTTGGGAGGTTGATGTGGGACAATCACTTGAGGTCAGAAGTTCGAGGCTGCAGTGAGCTATGATTAT


ACCACGGCACTCCAGCCTGGGTGGCAGAGCAAGACCCTGTTGCTGAAAACAAAACAAAACAAAACAAAAATGCTGCAACATTGCCTG


TGCTGCCTGGGGGCTCAGGGGATTGATGAGTAAGATGTGTTCTTTCATTCGGCAGCTCTCTGCTGAGCCCCAGTGGTGTGCCTGGCT


CTGGGCAAGGTTGCACAGAGCAATCCTTATGGGGTGCCCAGTCAGGAGCAGAGAAACATGATTGGGATGGCAGATGGAAGGCAGGTA


GATGTGGGGGCCTGAGAGAATGACAGGAGAGAGATGAGCCTTCAGAGGCTCTTTCAGGCTCCCCCGCACACTGCCTGATGTAGCTGC


CAGGGTCCAGCACCTGCTCTTGGCCAGCAGAGGCTAACTCCATGGCTGCAGTGTGAGTGTCAGCTGTGTAGTGGGGGTGTCCACTGG


CGCGACCCACACTGACCAGCCCCCTATCCTGGCAGGACCAGTATCAGCTGTGCTACCGTGCGGCCCTGGAGTACCTCGGCAGCTTTG


ACCACTATGCAACGTAACTACCGCTCCCCTCTCCTCCGCCACCCCCGCCGTGGGGCTCCGGAGGGGACCCAGCTCCTCTGAGCCATA


CCGACCATCGTCCAGCCCTCCTACGCAGATGCTGTCACTGGCAGAGCACAGCCCACGGGGATCACAGCGTTTCAGGAACGTTGCCAC


ACCAATCAGAGAGCCTAGAACATCCCTGGGCAAGTGGATGGCCCAGCAGGCAGGCACTGTGGCCCTTCTGTCCACCAGACCCACCTG


GAGCCCGCTTCAAGCTCTCTGTTGCGCTCCCGCATTTCTCATGCTTCTTCTCATGGGGTGGGGTTGGGGCAAAGCCTCCTTTTTAAT


ACATTAAGTGGGGTAGACTGAGGGATTTTAGCCTCTTCCCTCTGATTTTTCCTTTCGCGAATCCGTATCTGCAGAATGGGCCACTGT


AGGGGTTGGGGTTTATTTTGTTTTGTTTTTTTTTTTCTTGAGTTCACTTTCGATCCTTATTTTGTATGACTTCTGCTGAAGGACAGA


ACATTGCCTTCCTCGTGCAGAGCTGGGGCTGCCAGCCTGAGCGGAGGCTCGGCCGTGGGCCGGGAGGCAGTGCTGATCCGGCTGCTC


CTCCAGCCCTTCAGACGAGATCCTGTTTCAGCTAAATGCAGGGAAACTCAATGTTTTTTTAAGTTTTGTTTTCCCTTTAAAGCCTTT


TTTTAGGCCACATTGACAGTGGTGGGCGGGGAGAAGATAGGGAACACTCATCCCTGGTCGTCTATCCCAGTGTGTGTTTAACATTCA


CAGCCCAGAACCACAGATGTGTCTGGGAGAGCCTGGCAAGGCATTCCTCATCACCATCGTGTTTGCAAAGGTTAAAACAAAAACAAA


AAACCACAAAAATAAAAAACAAAAAAAACAAAAAACCCAAGAAAAAAAAAAAGAGTCAGCCCTTGGCTTCTGCTTCAAACCCTCAAG


AGGGGAAGCAACTCCGTGTGCCTGGGGTTCCCGAGGGAGCTGCTGGCTGACCTGGGCCCACAGAGCCTGGCTTTGGTCCCCAGCATT


GCAGTATGGTGTGGTGTTTGTAGGCTGTGGGGTCTGGCTGTGTGGCCAAGGTGAATAGCACAGGTTAGGCTGTGTGCCACACCCCAT


GCACCTCAGGGCCAAGCGGGGGCGTGGCTGGCCTTTCAGGTCCAGGCCAGTGGGCCTGGTAGCACATGTCTGTCCTCAGAGCAGGGG


CCAGATGATTTTCCTCCCTGGTTTGCAGCTGTTTTCAAAGCCCCCGATAATCGCTCTTTTCCACTCCAAGATGCCCTCATAAACCAA


TGTGGCAAGACTACTGGACTTCTATCAATGGTACTCTAATCAGTCCTTATTATCCCAGCTTGCTGAGCGGCAGGGACAGCGCCTCTT


CCTCTGGGCAGCGCTATCTAGATAGGTAAGTGGGGGCGGGGAAGGGTGCATAGCTGTTTTAGCTGAGGGACGTGGTGCCGACGTCCC


CAAACCTAGCTAGGCTAAGTCAAGATCAACATTCCAGGGTTGGTAATGTTGGATGATGAAACATTCATTTTTACCTTGTGGATGCTA


GTGCTGTAGAGTTCACTGTTGTACACAGTCTGTTTTCTATTTGTTAAGAAAAACTACAGCATCATTGCATAATTCTTGATGGTAATA


AATTTGAATAATCAGATTTCTTAC





HUMAN mRNA SEQUENCE: hR28-021.1 (Seq ID No: 67)


GGCGCCGCCGGGGGCGCGCACGGCAGGGGCAGGGGCGCGGGCGCGAGCGCGAGGGGAGCGCGCGGCTGGAGCTGGCGCGGGAGCGGC


GGGAGCGGTGGCGGCGGCAGAGGCGGCGGCTCCAGCTTCGGCTCCGGCTCGGGCTCGGGCTCCGGCTCCGGCTCCGGCTCCGGCTCC


AGCTCGGGTGGCGGTGGCGGGAGCGGGACCAGGTGGAGGCGGCGGCGGCAGAGGAGTGGGAGCAGCGGCCCTAGCGGCTTGCGGGGG


GACATGCGGACCGACGGCCCCTGGATAGGCGGAAGGAGTGGAGGCCCTGGTGCCCGGCCCTTGGTGCTGAGTATCCAGCAAGAGTGA


CCGGGGTGAAGAAGCAAAGACTCGGTTGATTGTCCTGGGCTGTGGCTGGCTGTGGAGCTAGAGCCCTGGATGGCCCCTGAGCCAGCC


CCAGGGAGGACGATGGTGCCCCTTGTGCCTGCACTGGTGATGCTTGGTTTGGTGGCAGGCGCCCATGGTGACAGCAAACCTGTCTTC


ATTAAAGTCCCTGAGGACCAGACTGGGCTGTCAGGAGGGGTAGCCTCCTTCGTGTGCCAAGCTACAGGAGAACCCAAGCCGCGCATC


ACATGGATGAAGAAGGGGAAGAAAGTCAGCTCCCAGCGCTTCGAGGTCATTGAGTTTGATGATGGGGCAGGGTCAGTGCTTCGGATC


CAGCCATTGCGGGTGCAGCGAGATGAAGCCATCTATGAGTGTACAGCTACTAACAGCCTGGGTGAGATCAACACTAGTGCCAAGCTC


TCAGTGCTCGAAGAGGAACAGCTGCCCCCTGGGTTCCCTTCCATCGACATGGGGCCTCAGCTGAAGGTGGTGGAGAAGGCACGCACA


GCCACCATGCTATGTGCCGCAGGCGGAAATCCAGACCCTGAGATTTCTTGGTTCAAGGACTTCCTTCCTGTAGACCCTGCCACGAGC


AACGGCCGCATCAAGCAGCTCCGTTCAGGTGCCTTGCAGATAGAGAGCAGTGAGGAATCCGACCAAGGCAAGTACGAGTGTGTGGCG


ACCAACTCGGCAGGCACACGTTACTCAGCCCCTGCGAACCTGTATGTGCGAGTGCGCCGCGTGGCTCCTCGTTTCTCCATCCCTCCC


AGCAGCCAGGAGGTGATGCCAGGCGGCAGCGTGAACCTGACATGCGTGGCAGTGGGTGCACCCATGCCCTACGTGAAGTGGATGATG


GGGGCCGAGGAGCTCACCAAGGAGGATGAGATGCCAGTTGGCCGCAACGTCCTGGAGCTCAGCAATGTCGTACGCTCTGCCAACTAC


ACCTGTGTGCCCATCTCCTCGCTGGGCATGATCGAGGCCACAGCCCAGGTCACAGTGAAAGCTCTTCCAAAGCCTCCGATTGATCTT


GTGGTGACAGAGACAACTGCCACCAGTGTCACCCTCACCTGGGACTCTGGGAACTCGGAGCCTGTAACCTACTATGGCATCCAGTAC


CGCGCAGCGGGCACGGAGGGCCCCTTTCAGGAGGTGGATGGTGTGGCCACCACCCGCTACAGCATTGGCGGCCTCAGCCCTTTCTCG


GAATATGCCTTCCGCGTGCTGGCGGTGAACAGCATCGGGCGAGGGCCGCCCAGCGAGGCAGTGCGGGCACGCACGGGAGAACAGGCG


CCCTCCAGCCCACCGCGCCGCGTGCAGGCACGCATGCTGAGCGCCAGCACCATGCTGGTGCAGTGGGAGCCTCCCGAGGAGCCCAAC


GGCCTGGTGCGGGGATACCGCGTCTACTATACTCCGGACTCCCGCCGCCCCCCGAACGCCTGGCACAAGCACAACACCGACGCGGGG


CTCCTCACGACCGTGGGCAGCCTGCTGCCTGGCATCACCTACAGCCTGCGCGTGCTTGCCTTCACCGCCGTGGGCGATGCCCCTCCC


AGCCCCACCATCCAGGTCAAGACGCAGCAGGGAGTGCCTGCCCAGCCCGCGGACTTCCAGGCCGAGGTGGAGTCGGACACCAGGATC


CAGCTCTCGTGGCTGCTGCCCCCTCAGGAGCGGATCATCATGTATGAACTGGTGTACTGGGCGGCAGAGGACGAAGACCAACAGCAC


AAGGTGACCTTCGACCCAACCTCCTCCTACACACTAGAGGACCTGAAGCCTGACACACTCTACCGCTTCCAGCTGGCTGCACGCTCG


GATATGGGGGTGGGCGTCTTCACCCCCACCATTGAGGCCCGCACAGCCCAGTCCACCCCCTCCGCCCCTCCCCAGAAGGTGATGTGT


GTGAGCATGGGCTCCACCACGGTCCGGGTAAGTTGGGTCCCGCCGCCTGCCGACAGCCGCAACGGCGTTATCACCCAGTACTCCGTG


GCCTACGAGGCGGTGGACGGCGAGGACCGCGGGCGGCATGTGGTGGATGGCATCAGCCGTGAGCACTCCAGCTGGGACCTGGTGGGC


CTGGAGAAGTGGACGGAGTACCGGGTGTGGGTGCGGGCACACACAGACGTGGGCCCCGGCCCCGAGAGCAGCCCGGTGCTGGTGCGC


ACCGATGAGGACGTGCCCAGCGGGCCTCCGCGGAAGGTGGAGGTGGAGCCACTGAACTCCACTGCTGTGCATGTCTACTGGAAGCTG


CCTGTCCCCAGCAAGCAGCATGGCCAGATCCGCGGCTACCAGGTCACCTACGTGCGGCTGGAGAATGGCGAGCCCCGTGGACTCCCC


ATCATCCAAGACGTCATGCTAGCCGAGGCCCAGTGGCGGCCAGAGGAGTCCGAGGACTATGAAACCACTATCAGCGGCCTGACCCCG


GAGACCACCTACTCCGTTACTGTTGCTGCCTATACCACCAAGGGGGATGGTGCCCGCAGCAAGCCCAAAATTGTCACTACAACAGGT


GCAGTCCCAGGCCGGCCCACCATGATGATCAGCACCACGGCCATGAACACTGCGCTGCTCCAGTGGCACCCACCCAAGGAACTGCCT


GGCGAGCTGCTGGGCTACCGGCTGCAGTACTGCCGGGCCGACGAGGCGCGGCCCAACACCATAGATTTCGGCAAGGATGACCAGCAC


TTCACAGTCACCGGCCTGCACAAGGGGACCACCTACATCTTCCGGCTTGCTGCCAAGAACCGGGCTGGCTTGGGTGAGGAGTTCGAG


AAGGAGATCAGGACCCCCGAGGACCTGCCCAGCGGCTTCCCCCAAAACCTGCATGTGACAGGACTGACCACGTCTACCACAGAACTG


GCCTGGGACCCGCCAGTGCTGGCGGAGAGGAACGGGCGCATCATCAGCTACACCGTGGTGTTCCGAGACATCAACAGCCAACAGGAG


CTGCAGAACATCACGACAGACACCCGCTTTACCCTTACTGGCCTCAAGCCAGACACCACTTACGACATCAAGGTCCGCGCATGGACC


AGCAAAGGCTCTGGCCCACTCAGCCCCAGCATCCAGTCCCGGACCATGCCGGTGGAGCAAGTGTTTGCCAAGAACTTCCGGGTGGCG


GCTGCAATGAAGACGTCTGTGCTGCTCAGCTGGGAGGTTCCCGACTCCTATAAGTCAGCTGTGCCCTTTAAGATTCTGTACAATGGG


CAGAGTGTGGAGGTGGACGGGCACTCGATGCGGAAGCTGATCGCAGACCTGCAGCCCAACACAGAGTACTCGTTTGTGCTGATGAAC


CGTGGCAGCAGCGCAGGGGGCCTGCAGCACCTGGTGTCCATCCGCACAGCCCCCGACCTCCTGCCTCACAAGCCGCTGCCTGCCTCT


GCCTACATAGAGGACGGCCGCTTCGATCTCTCCATGCCCCATGTGCAAGACCCCTCGCTTGTCAGGTGGTTCTACATTGTTGTGGTA


CCCATTGACCGTGTGGGCGGGAGCATGCTGACGCCAAGGTGGAGCACACCCGAGGAACTGGAGCTGGACGAGCTTCTAGAAGCCATC


GAGCAAGGCGGAGAGGAGCAGCGGCGGCGGCGGCGGCAGGCAGAACGTCTGAAGCCATATGTGGCTGCTCAACTGGATGTGCTCCCG


GAGACCTTTACCTTGGGGGACAAGAAGAACTACCGGGGCTTCTACAACCGGCCCCTGTCTCCGGACTTGAGCTACCAGTGCTTTGTG


CTTGCCTCCTTGAAGGAACCCATGGACCAGAAGCGCTATGCCTCCAGCCCCTACTCGGATGAGATCGTGGTCCAGGTGACACCAGCC


CAGCAGCAGGAGGAGCCGGAGATGCTGTGGGTGACGGGTCCCGTGCTGGCAGTCATCCTCATCATCCTCATTGTCATCGCCATCCTC


TTGTTCAAAAGGAAAAGGACCCACTCTCCGTCCTCTAAGGATGAGCAGTCGATCGGACTGAAGGACTCCTTGCTGGCCCACTCCTCT


GACCCTGTGGAGATGCGGAGGCTCAACTACCAGACCCCAGGTATGCGAGACCACCCACCCATCCCCATCACCGACCTGGCGGACAAC


ATCGAGCGCCTCAAAGCCAACGATGGCCTCAAGTTCTCCCAGGAGTATGAGTCCATCGACCCTGGACAGCAGTTCACGTGGGAGAAT


TCAAACCTGGAGGTGAACAAGCCCAAGAACCGCTATGCGAATGTCATCGCCTACGACCACTCTCGAGTCATCCTTACCTCTATCGAT


GGCGTCCCCGGGAGTGACTACATCAATGCCAACTACATCGATGGCTACCGCAAGCAGAATGCCTACATCGCCACGCAGGGCCCCCTG


CCCGAGACCATGGGCGATTTCTGGAGAATGGTGTGGGAACAGCGCACGGCCACTGTGGTCATGATGACACGGCTGGAGGAGAAGTCC


CGGGTAAAATGTGATCAGTACTGGCCAGCCCGTGGCACCGAGACCTGTGGCCTTATTCAGGTGACCCTGTTGGACACAGTGGAGCTG


GCCACATACACTGTGCGCACCTTCGCACTCCACAAGAGTGGCTCCAGTGAGAAGCGTGAGCTGCGTCAGTTTCAGTTCATGGCCTGG


CCAGACCATGGAGTTCCTGAGTACCCAACTCCCATCCTGGCCTTCCTACGACGGGTCAAGGCCTGCAACCCCCTAGACGCAGGGCCC


ATGGTGGTGCACTGCAGCGCGGGCGTGGGCCGCACCGGCTGCTTCATCGTGATTGATGCCATCTTGGAGCGGATGAAGCACGAGAAG


ACGGTGGACATCTATGGCCACGTGACCTGCATGCGATCACAGAGGAACTACATGGTGCAGACGGAGGACCAGTACGTGTTCATCCAT


GAGGCGCTGCTGGAGGCTGCCACGTGCGGCCACACAGAGGTGCCTGCCCGCAACCTGTATGCCCACATCCAGAAGCTGGGCCAAGTG


CCTCCAGGGGAGAGTGTGACCGCCATGGAGCTCGAGTTCAAGTTGCTGGCCAGCTCCAAGGCCCACACGTCCCGCTTCATCAGCGCC


ACCTGCCCTGCAACAAGTTCAAGAACCGGCTGGTGAACATCATGCCCTACGAATTGACCCGTGTGTGTCTGCAGCCCATCCGTAGGT


GTGGAGGGCTCTGACTACATCAATGCCAGCTTCCTGGATGGTTATAGACAGCAGAAGGCCTACATAGCTACACAGGGGCCTCTGGCA


GAGAGCACCGAGGACTTCTGGCGCATGCTATGGGAGCACAATTCCACCATCATCGTCATGCTGACCAAGCTTCGGGAGATGGGCAGG


GAGAAATGCCACCAGTACTGGCCAGCAGAGCGCTCTGCTCGCTACCAGTACTTTGTTGTTGACCCGATGGCTGAGTACAACATGCCC


CAGTATATCCTGCGTGAGTTCAAGGTCACGGATGCCCGGGATGGGCAGTCAAGGACAATCCGGCAGTTCCAGTTCACAGACTGGCCA


GAGCAGGGCGTGCCCAAGACAGGCGAGGGATTCATTGACTTCATCGGGCAGGTGCATAAGACCAAGGAGCAGTTTGGACAGGATGGG


CCTATCACGGTGCACTGCAGTGCTGGCGTGGGCCGCACCGGGGTGTTCATCACTCTGAGCATCGTCCTGGAGCGCATGCGCTACGAG


GGCGTGGTCGACATGTTTCAGACCGTGAAGACCCTGCGTACACAGCGTCCTGCCATGGTGCAGACAGAGGACCAGTATCAGCTGTGC


TACCGTGCGGCCCTGGAGTACCTCGGCAGCTTTGACCACTATGCAACGTAACTACCGCTCCCCTCTCCTCCGCCACCCCCGCCGTGG


GGCTCCGGAGGGGACCCAGCTCCTCTGAGCCATACCGACCATCGTCCAGCCCTCCTACGCAGATGCTGTCACTGGCAGAGCACAGCC


CACGGGGATCACAGCGTTTCAGGAACGTTGCCACACCAATCAGAGAGCCTAGAACATCCCTGGGCAAGTGGATGGCCCAGCAGGCAG


GCACTGTGGCCCTTCTGTCCACCAGACCCACCTGGAGCCCGCTTCAACCTCTCTGTTGCGCTCCCGCATTTCTCATGCTTCTTCTCA


TGGGGTGGGGTTGGGGCAAAGCCTCCTTTTTAATACATTAAGTGGGGTAGACTGAGGGATTTTAGCCTCTTCCCTCTGATTTTTCCT


TTCGCGAATCCGTATCTGCAGAATGGGCCACTGTAGGGGTTGGGGTTTATTTTGTTTTGTTTTTTTTTTTCTTGATTTGTATGACTT


CTGCTGAAGGACAGAACATTGCCTTCCTCGTGCAGAGCTGGGGCTGCCAGCCTGAGCGGAGGCTCGGCCGTGGGCCGGGAGGCAGTG


CTGATCCGGCTGCTCCTCCAGCCCTTCAGACGAGATCCTGTTTCAGCTAAATGCAGGGAAACTCAATGTTTTTTTAAGTTTTGTTTT


CCCTTTAAAGCCTTTTTTTAGGCCACATTGACAGTGGTGGGCGGGGAGAAGATAGGGAACACTCATCCCTGGTCGTCTATCCCAGTG


TGTGTTTAACATTCACAGCCCAGAACCACAGATGTGTCTGGGAGAGCCTGGCAAGGCATTCCTCATCACCATCGTGTTTGCAAAGGT


TAAAACAAAAACAAAAAACCACAAAAATAAAAAACAAAAAAAACAAAAAACCCAAGAAAAAAAAAAAGAGTCAGCCCTTGGCTTCTG


CTTCAAACCCTCAAGAGGGGAAGCAACTCCGTGTGCCTGGGGTTCCCGAGGGAGCTGCTGGCTGACCTGGGCCCACAGAGCCTGGCT


TTGGTCCCCAGCATTGCACTATGGTGTGGTGTTTGTAGGCTGTGGGGTCTGGCTGTGTGGCCAAGGTGAATAGCACAGGTTAGGGTG


TGTGCCACACCCCATGCACCTCAGGGCCAAGCGGGGGCGTGGCTGGCCTTTCAGGTCCAGGCCAGTGGGCCTGGTAGCACATGTCTG


TCCTCAGAGCAGGGGCCAGATGATTTTCCTCCCTGGTTTGCAGCTGTTTTCAAAGCCCCCGATAATCGCTCTTTTCCACTCCAAGAT


GCCCTCATAAACCAATGTGGCAAGACTACTGGACTTCTATCAATGGTACTCTAATCAGTCCTTATTATCCCAGCTTGCTGAGGGGCA


GGGAGAGCGCCTCTTCCTCTGGGCAGCGCTATCTAGATAGGTAAGTGGGGGCGGGGAAGGGTGCATAGCTGTTTTAGCTGAGGGACG


TGGTGCCGACGTCCCCAAACCTAGCTAGGCTAAGTCAAGATCAACATTCCAGGGTTGGTAATGTTGGATGATGGGGCATTCATTTTT


ACCTTGTGGATGCTAGTGCTGTAGAGTTCACTGTTGTACACAGTCTGTTTTCTATTTGTTAAGAAAAACTACAGCATCATTGCATAA


TTCTTGATGGTAATAAATTTGAATAATCAGATTTCTTAC





HUMAN PROTEIN SEQUENCE: hP28-021.1 (Seq ID No: 68)


MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGA


GSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGCNPDPEISWFKDFLP


VDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMP


YVKWMNGAEELTKEDEMPVGRNVLELSNVVRSAMYTCVAISSLGMIEATAQTVKALPKPPIDLVVTETTATSVTLTWDSGANSEPVT


YYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWE


PPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEV


ESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAP


PQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPES


SPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETT


ISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDF


GKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRD


INSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPF


KILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRW


FYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDL


SYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLNVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDS


LLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLANNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRV


ILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTL


LDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAILE


RMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHT


SRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTK


LREMGREKCNQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVNKTKE


QFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT*





HUMAN mRNA SEQUENCE: hR28-021.2 (Seq ID No: 69)


GGCGCCGCCGGGGGCGCGCACGGCAGGGGCAGGGGCGCGGGCGCGAGCGCGAGGGGAGCGCGCGGCTGGAGCTGGCGCGGGAGCGGC


GGGAGCGGTGGCGGCGGCAGAGGCGGCGGCTCCAGCTTCGGCTCCGGCTCGGGCTCGGGCTCCOGCTCCGGCTCCGGCTCCGGCTCC


AGCTCGGGTGGCGGTGGCGGGAGCGGGACCAGGTGGAGGCGGCGGCGGCAGAGGAGTGGGAGCAGCGGCCCTAGCGGCTTGCGGGGG


GACATGCGGACCGACGGCCCCTGGATAGGCGGAAGGAGTGGAGGCCCTGGTGCCCGGCCCTTGGTGCTGAGTATCCAGCAAGAGTGA


CCGGGGTGAAGAAGCAAAGACTCGGTTGATTGTCCTCGGCTGTGGCTGGCTGTGGAGCTAGAGCCCTGGATGGCCCCTGAGCCAGCC


CCAGGGAGGACGATGGTGCCCCTTGTGCCTGCACTGGTGATGCTTGGTTTGGTGGCAGGCGCCCATGGTGACAGCAAACCTGTCTTC


ATTAAAGTCCCTGAGGACCAGACTGGGCTGTCAGGAGGGGTAGCCTCCTTCGTGTGCCAAGCTACAGGAGAACCCAAGCCGCGCATC


ACATGGATGAAGAAGGGGAAGAAAGTCAGCTCCCAGCGCTTCGAGGTCATTGAGTTTGATGATGGGGCAGGGTCAGTGCTTCGCATC


CAGCCATTGCGGGTGCAGCGAGATGAGCCATCTATGAGTGTACAGCTACTAACAGCCTGGGTGAGAATCAACACTAGTGCCAAGCTC


TCAGTGCTCGAAGAGGAACAGCTGCCCCCTGGGTTCCCTTCCATCGACATGGGGCCTCAGCTGAAGGTGGTGGAGAAGGCACGCACA


GCCACCATGCTATGTGCCGCAGGCGGAAATCCAGACCCTGAGATTTCTTGGTTCAAOGACTTCCTTCCTGTAGACCCTGCCACGAGC


AACGGCCGCATCAAGCAGCTGCGTTCAGGTGCCTTGCAGATAGAGAGCAGTGAGGAATCCCACCAAGGCAAGTACGAGTGTGTGGCG


ACCAACTCGGCAGGCACACGTTACTCAGCCCCTGCGAACCTGTATGTGCGAGTGCGCCGCGTGGCTCCTCGTTTCTCCATCCCTCCC


AGCAGCCAGGAGGTGATGCCAGGCGGCAGCGTGAACCTGACATGCGTGGCAGTGGGTGCACCCATGCCCTACGTGAAGTGGATGATG


GGGGCCGAGGAGCTCACCAAGGAGGATGAGATGCCAGTTGGCCGCAACGTCCTGGAGCTCAGCAATGTCGTACGCTCTGCCAACTAC


ACCTGTGTGGCCATCTCCTCGCTGGGCATGATCGAGGCCACAGCCCAGGTCACAGTGAAAGCTCTTCCAAAGCCTCCGATTGATCTT


GTGGTGACAGAGACAACTGCCACCAGTGTCACCCTCACCTGGGACTCTOGGAACTCGGAGCCTGTAACCTACTATGGCATCCAGTAC


CGCGCAGCGGGCACGGAGGGCCCCTTTCAGGAGGTGGATGGTGTGGCCACCACCCGCTACAGCATTGGCGGCCTCAGCCCTTTCTCG


GAATATGCCTTCCGCGTGCTGGCGGTGAACAGCATCGGGCGAGGGCCGCCCAGCGAGGCAGTGCGGGCACGCACGGGAGAACAGGCG


CCCTCCAGCCCACCGCGCCGCGTGCAGGCACGCATGCTGAGCGCCAGCACCATGCTGGTGCAGTGGGAGCCTCCCGAGGAGCCCAAC


GGCCTGGTGCGGGGATACCGCGTCTACTATACTCCGGACTCCCGCCGCCCCCCGAACGCCTGGCACAAGCACAACACCGACGCGGGG


CTCCTCACGACCGTGGGCAGCCTGCTGCCTGGCATCACCTACAGCCTGCGCGTGCTTGCCTTCACCGCCGTGGGCGATGGCCCTCCC


AGCCCCACCATCCAGGTCAAGACGCAGCAGGGAGTGCCTGCCCAGCCCGCGGACTTCCAGGCCGAGGTGGAGTCGGACACCAGGATC


CAGCTCTCGTGGCTGCTGCCCCCTCAGGAGCGGATCATCATGTATGAACTOGTGTACTGGGCGGCAGAGGACGAAGACCAACAGCAC


AAGGTGACCTTCGACCCAACCTCCTCCTACACACTAGAGGACCTGAAGCCTGACACACTCTACCGCTTCCAGCTGGCTGCACGCTCG


GATATGGGGCTGGGCGTCTTCACCCCCACCATTGAGGCCCGCACAGCCCAGTCCACCCCCTCCGCCCCTCCCCAGAAGGTGATGTGT


GTGAGCATGGGCTCCACCACGGTCCGGGTAAGTTGGGTCCCGCCGCCTGCCGACAGCCGCAACGGCGTTATCACCCAGTACTCCGTG


GCCTACGAGGCGGTGGACGGCGAGGACCGCGGGCGGCATGTGGTGGATGGCATCAGCCGTGAGCACTCCAGCTGGGACCTGGTGGGC


CTGGAGAAGTGGACGGAGTACCGGGTGTGGGTGCGGGCACACACAGACGTGGGCCCCGGCCCCGAGAGCAGCCCGGTGCTGGTGCGC


ACCGATGAGGACGTGCCCAGCGGGCCTCCGCGGAAGGTGGAGGTGGAGCCACTGAACTCCACTGCTGTGCATGTCTACTGGAAGCTG


CCTGTCCCCAGCAAGCAGCATGGCCAGATCCGCGGCTACCAGGTCACCTACGTGCGGCTGGAGAATGGCGAGCCCCGTGGACTCCCC


ATCATCCAAGACGTCATGCTAGCCGAGGCCCAGGAAACCACTATCAGCGGCCTGACCCCGGAGACCACCTACTCCCTTACTGTTGCT


GCCTATACCACCAAGGGGGATGGTGCCCGCAGCAAGCCCAAAATTGTCACTACAACAGGTGCAGTCCCAGGCCGGCCCACCATGATG


ATCAGCACCACGGCCATGAACACTGCGCTGCTCCAGTGGCACCCACCCAAGGAACTGCCTGGCGAGCTGCTGGGCTACCGGCTGCAG


TACTGCCGGGCCGACGAGGCGCGGCCCAACACCATAGATTTCGGCAAGGATGACCAGCACTTCACAGTCACCCGCCTGCACAAGGGG


ACCACCTACATCTTCCGGCTTGCTGCCAAGAACCGGGCTGGCTTGGGTGAGGAGTTCGAGAAGGAGATCAGGACCCCCGAGGACCTG


CCCAGCGGCTTCCCCCAAAACCTGCATGTGACAGGACTGACCACGTCTACCACAGAACTGGCCTGGGACCCGCCAGTGCTGGCGGAG


AGGAACGGGCGCATCATCAGCTACACCGTGGTGTTCCGAGACATCAACAGCCAACAGGAGCTGCAGAACATCACGACAGACACCCGC


TTTACCCTTACTGGCCTCAAGCCAGACACCACTTACGACATCAAGGTCCGCGCATGGACCAGCAAAGGCTCTGGCCCACTCAGCCCC


AGCATCCAGTCCCGGACCATGCCGGTGGAGCAAGTGTTTGCCAAGAACTTCCGGGTGGCGGCTGCAATGAAGACGTCTGTGCTGCTC


AGCTGGGAGGTTCCCGACTCCTATAAGTCAGCTGTGCCCTTTAAGATTCTGTACAATGGGCAGAGTGTGGAGGTGGACGGGCACTCG


ATGCGGAAGCTGATCGCAGACCTGCAGCCCAACACAGAGTACTCGTTTGTGCTGATGAACCGTGGCAGCAGCGCAGGGGGCCTGCAG


CACCTGGTGTCCATCCGCACAGCCCCCGACCTCCTGCCTCACAAGCCGCTGCCTGCCTCTGCCTACATAGAGGACGGCCGCTTCGAT


CTCTCCATGCCCCATGTGCAAGACCCCTCGCTTGTCAGGTGGTTCTACATTGTTGTGGTACCCATTGACCGTGTGGGCGGGAGCATG


CTGACGCCAAGGTGGAGCACACCCGAGGAACTGGAGCTGGACGAGCTTCTAGAAGCCATCGAGCAAGGCGGAGAGGAGCAGCGGCGG


CGGCGGCGGCAGGCAGAACGTCTGAAGCCATATGTGGCTGCTCAACTGGATGTGCTCCCGGAGACCTTTACCTTGGGGGACAAGAAG


AACTACCGGGGCTTCTACAACCGGCCCCTGTCTCCGGACTTGAGCTACCAGTGCTTTGTGCTTGCCTCCTTGAAGGAACCCATGGAC


CAGAAGCGCTATGCCTCCAGCCCCTACTCGGATGAGATCGTGGTCCAGGTGACACCAGCCCAGCAGCAGGAGGAGCCGGAGATGCTG


TGGGTGACGGGTCCCGTGCTGGCAGTCATCCTCATCATCCTCATTGTCATCGCCATCCTCTTGTTCAAAAGGAAAAGGACCCACTCT


CCGTCCTCTAAGGATGAGCAGTCGATCGGACTGAAGGACTCCTTGCTGGCCCACTCCTCTGACCCTGTGGAGATGCGGAGGCTCAAC


TACCAGACCCCAGGTATGCGAGACCACCCACCCATCCCCATCACCGACCTGGCGGACAACATCGAGCGCCTCAAAGCCAACGATGGC


CTCAAGTTCTCCCAGGAGTATGAGTCCATCGACCCTGGACAGCAGTTCACGTGGGAGAATTCAAACCTGGAGGTGAACAAGCCCAAG


AACCGCTATGCGAATGTCATCGCCTACGACCACTCTCGAGTCATCCTTACCTCTATCGATGGCGTCCCCGGGAGTGACTACATCAAT


GCCAACTACATCGATGGCTACCGCAAGCAGAATGCCTACATCGCCACGCAGGGCCCCCTGCCCGAGACCATGGGCGATTTCTGGAGA


ATGGTGTGGGAACAGCGCACGGCCACTGTGGTCATGATGACACGGCTGGAGGAGAAGTCCCGGGTAAAATGTGATCAGTACTGGCCA


GCCCGTGGCACCGAGACCTGTGGCCTTATTCAGGTGACCCTGTTGGACACAGTGGAGCTGGCCACATACACTGTGCGCACCTTCGCA


CTCCACAAGAGTGGCTCCAGTGAGAAGCGTGAGCTGCGTCAGTTTCAGTTCATGGCCTGGCCAGACCATGGAGTTCCTGAGTACCCA


ACTCCCATCCTGGCCTTCCTACGACGGGTCAAGGCCTGCAACCCCCTAGACGCAGGGCCCATGGTGGTGCACTGCAGCGCGGGCGTG


GGCCGCACCGGCTGCTTCATCGTGATTGATGCCATGTTGGAGCGGATGAAGCACGAGAAGACGGTGGACATCTATGGCCACGTGACC


TGCATGCGATCACAGAGGAACTACATGGTGCAGACGGAGGACCAGTACGTGTTCATCCATGAGGCGCTGCTGGAGGCTGCCACGTGC


GGCCACACAGAGGTGCCTGCCCGCAACCTGTATGCCCACATCCAGAAGCTGGGCCAAGTGCCTCCAGGGGAGAGTGTGACCGCCATG


GAGCTCGAGTTCAAGTTGCTGGCCAGCTCCAAGGCCCACACGTCCCGCTTCATCAGCGCCAACCTGCCCTGCAACAAGTTCAAGAAC


CGGCTGGTGAACATCATGCCCTACGAATTGACCCGTGTGTGTCTGCAGCCCATCCGTGGTGTGGAGGGCTCTGACTACATCAATGCC


AGCTTCCTGGATGGTTATAGACAGCAGAAGGCCTACATAGCTACACAGGGGCCTCTGGCAGAGAGCACCGAGGACTTCTGGCGCATG


CTATGGGAGCACAATTCCACCATCATCGTCATGCTGACCAAGCTTCGGGAGATGGGCAGGGAGAAATGCCACCAGTACTGGCCAGCA


GAGCGCTCTGCTCGCTACCAGTACTTTGTTGTTGACCCGATGGCTGAGTACAACATGCCCCAGTATATCCTGCGTGAGTTCAAGGTC


ACGGATGCCCGGGATGGGCAGTCAAGGACAATCCGGCAGTTCCAGTTCACAGACTGGCCAGAGCAGGGCGTGCCCAAGACAGGCGAG


GGATTCATTGACTTCATCGGGCAGGTGCATAAGACCAAGGAGCAGTTTGGACAGGATGGGCCTATCACGGTGCACTGCAGTGCTGGC


GTGGGCCGCACCGGGGTGTTCATCACTCTGAGCATCGTCCTGGAGCGCATGCGCTACGAGGGCGTGGTCGACATGTTTCAGACCGTG


AAGACCCTGCGTACACAGCGTCCTGCCATGGTGCAGACAGAGGACCAGTATCAGCTGTGCTACCGTGCGGCCCTGGAGTACCTCGGC


AGCTTTGACCACTATGCAACGTAACTACCGCTCCCCTCTCCTCCGCCACCCCCGCCGTGGGGCTCCGGAGGGGACCCAGCTCCTCTG


AGCCATACCGACCATCGTCCAGCCCTCCTACGCAGATGCTGTCACTGGCAGAGCACAGCCCACGGGGATCACAGCGTTTCAGGAACG


TTGCCACACCAATCAGAGAGCCTAGAACATCCCTGGGCAAGTGGATGGCCCAGCAGGCAGGCACTGTGGCCCTTCTGTCCACCAGAC


CCACCTGGAGCCCGCTTCAAGCTCTCTGTTGCGCTCCCGCATTTCTCATGCTTCTTCTCATGGGGTGGGGTTGGGGCAAAGCCTCCT


TTTTAATACATTAAGTGGGGTAGACTGAGGGATTTTAGCCTCTTCCCTCTGATTTTTCCTTTCGCGAATCCGTATCTGCAGAATGGG


CCACTGTAGGGGTTGGGGTTTATTTTGTTTTGTTTTTTTTTTTCTTGATTTGTATGACTTCTGCTGAAGGACAGAACATTGCCTTCC


TCGTGCAGAOCTGGGGCTGCCAGCCTGAGCGGAGGCTCGGCCGTGGGCCGGGAGGCAGTGCTGATCCGGCTGCTCCTCCAGCCCTTC


AGACGAGATCCTGTTTCAGCTAAATGCAGGGAAACTCAATGTTTTTTTAAGTTTTGTTTTCCCTTTAAAGCCTTTTTTTAGGCCACA


TTGACAGTGGTGGGCGGGGAGAAGATAGGGAACACTCATCCCTGGTCGTCTATCCCAGTGTCTGTTTAACATTCACAGCCCAGAACC


ACAGATGTGTCTGGGAGAGCCTGGCAAGGCATTCCTCATCACCATCGTGTTTGCAAAGGTTAAAACAAAAACAAAAAACCACAAAAA


TAAAAAACAAAAAAAACAAAAAACCCAAGAAAAAAAAAAAGAGTCAGCCCTTGGCTTCTGCTTCAAACCCTCAAGAGGGOAAGCAAC


TCCGTGTGCCTGGGGTTCCCGAGGGAGCTGCTGGCTGACCTGGGCCCACAGAGCCTGGCTTTGGTCCCCAGCATTGCAGTATGGTGT


GGTGTTTGTAGGCTGTGGGGTCTGGCTGTGTGGCCAAGGTGAATAGCACAGGTTAGGGTGTGTGCCACACCCCATGCACCTCAGGGC


CAAGCGGGGGCGTGGCTGGCCTTTCAGGTCCAGGCCAGTGOGCCTGGTAGCACATGTCTGTCCTCAGAGCAGGGGCCAOATGATTTT


CCTCCCTGGTTTGCAGCTGTTTTCAAAGCCCCCGATAATCGCTCTTTTCCACTCCAAGATGCCCTCATAAACCAATGTGGCAAGACT


ACTGGACTTCTATCAATGGTACTCTAATCAGTCCTTATTATCCCAGCTTGCTGAGGCGCAGGGAGAGCGCCTCTTCCTCTGGGCAGC


GCTATCTAGATAGGTAAGTGGGGGCGGGGAAGGGTGCATAGCTGTTTTAGCTGAGGGACGTGGTGCCGACGTCCCCAAACCTAGCTA


GGCTAAGTCAAGATCAACATTCCAGGGTTGGTAATGTTGGATGATGAAACATTCATTTTTACCTTGTGGATGCTAGTGCTGTAGAGT


TCACTGTTGTACACAGTCTGTTTTCTATTTGTTAAGAAAAACTACAGCATCATTGCATAATTCTTGATGGTAATAAATTTGAATAAT


CAGATTTCTTAC





HUMAN PROTEIN SEQUENCE: hP28-021.2 (Seq ID No: 70)


MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATCEPKPRITWMKKGKKVSSQRFEVIEFDDGA


GSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLP


VDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMP


YVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVT


YYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWE


PPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEV


ESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAP


PQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRORHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPES


SPVLVRTDEDVPSOPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETT


YSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTANNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTV


TGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQN


ITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAANKTSVLLSWEVPDSYKSAVPFKILYNGQSV


EVDGHSMRKLIANLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPID


RVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLAS


LKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPV


EMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVP


GSDYINAYIDGYRKQNAYIATQGPLPETMGDFWRNVWEQRTATVVIMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATY


TVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDANLERMKHEKTVD


IYGHTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNNYLAHIQKLGQVPPGASVTANELEFKLLASSKAMTSRFISANLP


CNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVHLTKLREMGREKC


HQYWPAERSARYQYFVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQPTDWPEQGVPKTGEGFIDFIGQAVHKTKEQFGQDGPIT


VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT*





HUMAN mRNA SEQUENCE: hR28-021.3 (Seq ID No: 71)


GCGTGTGTGGACTGAAACCCAAAAGCCAGAAACTCTCTGCATGTGTCCCTCATGGAGCCATATGGTCTCTAGTCTCTGTTTTTCAAA


ATTTGCAGGACTGATGACTGATTGGACAGTGGTGCAGGAGGGAAGGTCTCTGCATGTCAGTGATTAAATTGCTGAAGATGCCACTGC


CTGAGACGGGCAGTATTGAAGGAAGGAGTGGAGGCCCTGGTGCCCGGCCCTTGGTGCTGAGTATCCAGCAAGAGTGACCGGGGTGAA


GAAGCAAAGACTCGGTTGATTGTCCTGGGCTGTGGCTGGCTGTGGAGCTAGAGCCCTGGATGGCCCCTGAGCCAGCCCCAGGGAGGA


CGATGGTGCCCCTTGTGCCTGCACTGGTGATGCTTGGTTTGGTGGCAGGCGCCCATGGTGACAGCAAACCTGTCTTCATTAAAGTCC


CTGAGGACCAGACTGGGCTGTCAGGAGGGGTAGCCTCCTTCGTGTGCCAAGCTACAGGAGAACCCAAGCCGCGCATCACATGGATGA


AGAAGGGGAAGAAAGTCAGCTCCCAGCGCTTCGAGGTCATTGAGTTTGATGATGGGGCAGGGTCAGTGCTTCGGATCCAGCCATTGC


GGGTGCAGCGAGATGAAGCCATCTATGAGTGTACAGCTACTAACAGCCTGGGTGAGATCAACACTAGTGCCAAGCTCTCAGTGCTCG


AAGAGGAACAGCTGCCCCCTGGGTTCCCTTCCATCGACATGGGGCCTCAGCTGAAGGTGGTGGAGAAGGCACGCACAGCCACCATGC


TATGTGCCGCAGGCGGAAATCCAGACCCTGAGATTTCTTGGTTCAAGGACTTCCTTCCTGTAGACCCTGCCACGAGCAACGGCCGCA


TCAAGCAGCTGCGTTCAGGTGCCTTGCAGATAGAGAGCAGTGAGGAATCCGACCAAGGCAAGTACGAGTGTGTGGCGACCAACTCGG


CAGGCACACGTTACTCAGCCCCTGCGAACCTGTATGTGCGAGTGCGCCGCGTGGCTCCTCGTTTCTCCATCCCTCCCAGCAGCCAGG


AGGTGATGCCAGGCGGCAGCGTGAACCTGACATGCGTGGCAGTGGGTGCACCCATGCCCTACGTGAAGTGGATGATGGGGGCCGAGG


AGCTCACCAAGGAGGATGAGATGCCAGTTGGCCGCAACGTCCTGGAGCTCAGCAATGTCGTACGCTCTGCCAACTACACCTGTGTGG


CCATCTCCTCGCTGGGCATGATCGAGGCCACAGCCCAGGTCACAGTGAAAGCTCTTCCAAAGCCTCCGATTGATCTTGTGGTGACAG


AGACAACTGCCACCAGTGTCACCCTCACCTGGGACTCTGGGAACTCGGAGCCTGTAACCTACTATGGCATCCAGTACCGCGCAGCGG


GCACGGAGGGCCCCTTTCAGGAGGTGGATGGTGTGGCCACCACCCGCTACAGCATTGGCGGCCTCAGCCCTTTCTCGGAATATGCCT


TCCGCGTGCTGGCGGTGAACAGCATCGGGCGAGGGCCGCCCAGCGAGGCAGTGCGGGCACGCACGGGAGAACAGGCGCCCTCCAGCC


CACCGCGCCGCGTGCAGGCACGCATGCTGAGCGCCAGCACCATGCTGGTGCAGTGGGAGCCTCCCGAGGAGCCCAACGGCCTGGTGC


GGGGATACCGCGTCTACTATACTCCGGACTCCCGCCGCCCCCCGAACGCCTGGCACAAGCACAACACCGACGCGGGGCTCCTCACGA


CCGTGGGCAGCCTGCTGCCTGGCATCACCTACAGCCTGCGCGTGCTTGCCTTCACCGCCGTGGGCGATGGCCCTCCCAGCCCCACCA


TCCAGGTCAAGACGCAGCAGGGAGTGCCTGCCCAGCCCGCGGACTTCCAGGCCGAGGTGGAGTCGGACACCAGGATCCAGCTCTCGT


GGCTGCTGCCCCCTCAGGAGCGGATCATCATGTATGAACTGGTGTACTGGGCGGCAGAGGACGAAGACCAACAGCACAAGGTGACCT


TCGACCCAACCTCCTCCTACACACTAGAGGACCTGAAGCCTGACACACTCTACCGCTTCCAGCTGGCTGCACGCTCGGATATGGGGG


TGGGCGTCTTCACCCCCACCATTGAGGCCCGCACAGCCCAGTCCACCCCCTCCGCCCCTCCCCAGAAGGTGATGTGTGTGAGCATGG


GCTCCACCACGGTCCGGGTAAGTTGGGTCCCGCCGCCTGCCGACAGCCGCAACGGCGTTATCACCCAGTACTCCGTGGCCTACGAGG


CGGTGGACGGCGAGGACCGCGGGCGGCATGTGGTGGATGGCATCAGCCGTGAGCACTCCAGCTGGGACCTGGTGGGCCTGGAGAAGT


GGACGGAGTACCGGGTGTGGGTGCGGGCACACACAGACGTGGGCCCCGGCCCCGAGAGCAGCCCGGTGCTGGTGCGCACCGATGAGG


ACGTGCCCAGCGGGCCTCCCCGGAAGGTGGAGGTGGAGCCACTGAACTCCACTGCTGTGCATGTCTACTGGAAGCTGCCTGTCCCCA


GCAAGCAGCATGGCCGGATCCGCGGCTACCAGGTCACCTACGTGCGGCTGGAGAATGGCGAGCCCCGTGGACTCCCCATCATCCAAG


ACGTCATGCTAGCCGAGGCCCAGGAAACCACTATCAGCGGCCTGACCCCGGAGACCACCTACTCCGTTACTGTTGCTGCCTATACCA


CCAAGGGGGATGGTGCCCGCAGCAAGCCCAAAATTGTCACTACAACAGGTGCAGTCCCAGGCCGGCCCACCATGATGATCAGCACCA


CGGCCATGAACACTGCGCTGCTCCAGTGGCACCCACCCAAGGAACTGCCTGGCGAGCTGCTGGGCTACCGGCTGCAGTACTGCCGGG


CCGACGAGGCGCGGCCCAACACCATAGATTTCGGCAAGGATGACCAGCACTTCACAGTCACCGGCCTGCACAAGGGGACCACCTACA


TCTTCCGGCTTGCTGCCAAGAACCGGGCTGGCTTGGGTGAGGAGTTCGAGAAGGAGATCAGGACCCCCGAGGACCTGCCCAGCGGCT


TCCCCCAAAACCTGCATGTGACAGGACTGACCACGTCTACCACAGAACTGGCCTGGGACCCGCCAGTGCTGGCGGAGAGGAACGGGC


GCATCATCAGCTACACCGTGGTGTTCCGAGACATCAACAGCCAACAGGAGCTGCAGAACATCACGACAGACACCCGCTTTACCCTTA


CTGGCCTCAAGCCAGACACCACTTACGACATCAAGGTCCGCGCATGGACCAGCAAAGGCTCTGGCCCACTCAGCCCCAGCATCCAGT


CCCGGACCATGCCGGTGGAGCAAGTGTTTGCCAAGAACTTCCGGGTGGCGGCTGCAATGAAGACGTCTGTGCTGCTCAGCTGGGAGG


TTCCCGACTCCTATAAGTCAGCTGTGCCCTTTAAGATTCTGTACAATGGGCAGAGTGTGGAGGTGGACGGGCACTCGATGCGGAAGC


TGATCGCAGACCTGCAGCCCAACACAGAGTACTCGTTTGTGCTGATGAACCGTGGCAGCAGCGCAGGGGGCCTGCAGCACCTGGTGT


CCATCCGCACAGCCCCCGACCTCCTGCCTCACAAGCCGCTGCCTGCCTCTGCCTACATAGAGGACGGCCGCTTCGATCTCTCCATGC


CCCATGTGCAAGACCCCTCGCTTGTCAGGTGGTTCTACATTGTTGTGGTACCCATTGACCGTGTGGGCGGGAGCATGCTGACGCCAA


GGTGGAGCACACCCGAGGAACTGGAGCTGGACGAGCTTCTAGAAGCCATCGAGCAAGGCGGAGAGGAGCAGCGGCGGCQGCGGCGGC


AGGCAGAACGTCTGAAGCCATATGTGGCTGCTCAACTGGATGTGCTCCCGGAGACCTTTACCTTGGGGGACAAGAAGAACTACCGGG


GCTTCTACAACCGGCCCCTGTCTCCGGACTTGAGCTACCAGTGCTTTGTGCTTGCCTCCTTGAAGGAACCCATGGACCAGAAGCGCT


ATGCCTCCAGCCCCTACTCGGATGAGATCGTGGTCCAGGTGACACCAGCCCAGCAGCAGGAGGAGCCGGAGATGCTGTGGGTGACGG


GTCCCGTGCTGGCAGTCATCCTCATCATCCTCATTGTCATCGCCATCCTCTTGTTCAAAAGGAAAAGGACCCACTCTCCGTCCTCTA


AGGATGAGCAGTCGATCGGACTGAAGGACTCCTTGCTGGCCCACTCCTCTGACCCTGTGGAGATGCGGAGGCTCAACTACCAGACCC


CAGGTATGCGAGACCACCCACCCATCCCCATCACCGACCTGGCGGACAACATCGAGCGCCTCAAAGCCAACGATGGCCTCAAGTTCT


CCCAGGAGTATGAGTCCATCGACCCTGGACAGCAGTTCACGTGGGAGAATTCAAACCTGGAGGTGAACAAGCCCAAGAACCGCTATG


CGAATGTCATCGCCTACGACCACTCTCGAGTCATCCTTACCTCTATCGATGGCGTCCCCGGGAGTGACTACATCAATGCCAACTACA


TCGATGGCTACCGCAAGCAGAATGCCTACATCGCCACGCAGGGCCCCCTGCCCGAGACCATGGGCGATTTCTGGAGAATGGTGTGGG


AACAGCGCACGGCCACTGTGGTCATGATGACACGGCTGGAGGAGAAGTCCCGGGTAAAATGTGATCAGTACTGGCCAGCCCGTGGCA


CCGAGACCTGTGGCCTTATTCAGGTGACCCTGTTGGACACAGTGGAGCTGGCCACATACACTGTGCGCACCTTCGCACTCCACAAGA


GTGGCTCCAGTGAGAAGCGTGAGCTGCGTCAGTTTCAGTTCATGGCCTGGCCAGACCATGGAGTTCCTGAGTACCCAACTCCCATCC


TGGCCTTCCTACGACCGGTCAAGGCCTGCAACCCCCTAGACGCAGGGCCCATGGTGGTGCACTGCAGCGCGGGCGTGGGCCGCACCG


GCTGCTTCATCGTGATTGATGCCATGTTGGAGCGGATGAAGCACGAGAAGACGGTGGACATCTATGGCCACGTGACCTGCATGCGAT


CACAGAGGAACTACATGGTGCAGACGGAGGACCAGTACGTGTTCATCCATGAGGCGCTGCTGGAGGCTGCCACGTGCGGCCACACAG


AGGTGCCTGCCCGCAACCTGTATGCCCACATCCAGAAGCTGGGCCAAGTGCCTCCAGGGGAGAGTGTGACCGCCATGGAGCTCGAGT


TCAAGTTGCTGGCCAGCTCCAAGGCCCACACGTCCCGCTTCATCAGCGCCAACCTGCCCTGCAACAAGTTCAAGAACCGGCTGGTGA


ACATCATGCCCTACGAATTGACCCGTGTGTGTCTGCAGCCCATCCGTGGTGTGGAGGGCTCTGACTACATCAATGCCAGCTTCCTGG


ATGGTTATAGACAGCAGAAGGCCTACATAGCTACACAGGGGCCTCTGGCAGAGAGCACCGAGGACTTCTGGCGCATGCTATGGGAGC


ACAATTCCACCATCATCGTCATCCTGACCAAGCTTCGGGAGATGGGCAGGGAGAAATGCCACCAGTACTGGCCAGCAGAGCGCTCTG


CTCGCTACCAGTACTTTGTTGTTGACCCGATGGCTGAGTACAACATGCCCCAGTATATCCTCCGTGAGTTCAAGGTCACGGATGCCC


GGGATGGGCAGTCAAGGACAATCCGGCAGTTCCAGTTCACAGACTGGCCAGAGCAGGGCGTGCCCAAGACAGGCGAGGGATTCATTG


ACTTCATCGGGCAGGTGCATAAGACCAAGGAGCAGTTTGGACAGGATGGGCCTATCACGGTGCACTGCAGTGCTGGCGTGGGCCGCA


CCGGGGTGTTCATCACTCTGAGCATCGTCCTGGAGCGCATGCGCTACGAGGGCGTGGTCGACATGTTTCAGACCGTGAAGACCCTGC


GTACACAGCGTCCTGCCATGGTGCAGACAGAGGACCAGTATCAGCTGTGCTACCGTGCGGCCCTGGAGTACCTCGGCAGCTTTGACC


ACTATGCAACGTAACTACCGCTCCCCTCTCCTCCGCCACCCCCGCCGTGGGGCTCCGGAGGGGACCCAGCTCCTCTGAGCCATACCG


ACCATCGTCCAGCCCTCCTACGCAGATGCTGTCACTGGCAGAGCACAGCCCACGGGGATCACAGCGTTTCAGGAACGTTGCCACACC


AATCAGAGAGCCTAGAACATCCCTGGGCAAGTGGATGGCCCAGCGGGCAGGCACTGTGGCCCTTCTGTCCACCAGACCCACCTGGAG


CCCGCTTCAAGCTCTCTGTTGCGCTCCCGCATTTCTCATGCTTCTTCTCATGGGGTGGGGTTGGGGCAAAGCCTCCTTTTTAATACA


TTAAGTGGGGTAGACTGAGGGATTTTAGCCTCTTCCCTCTGATTTTTCCTTTCGCGAATCCGTATCTGCAGAATGGGCCACTGTAGG


GGTTGGGGTTTATTTTGTTTTGTTTTTTTTTTTCTTGATTTGTATGACTTCTGCTGAAGGACAGAACATTGCCTTCCTCGTGCAGAG


CTGGGGCTGCCAGCCTGAGCGGAGGCTCGGCCGTGGGCCGGGAGGCAGTGCTGATCCGGCTGCTCCTCCAGCCCTTCAGACGAGATC


CTGTTTCAGCTAAATGCAGGGAAACTCAATGTTTTTTTAAGTTTTGTTTTCCCTTTAAAGCCTTTTTTTAGGCCACATTGACAGTGG


TGGGCGGGGAGAAGATAGGGAACACTCATCCCTGGTCGTCTATCCCAGTGTGTGTTTAACATTCACAGCCCAGAACCACAGATGTGT


CTGGGAGAGCCTGGCAAGGCATTCCTCATCACCATCGTGTTTGCAAAGGTTAAAACAACAAAAAACCAAAACAAAAATAAAAAACAA


AAAAAACAAAAAACCCAAGAAAAAAAAAAAGAGTCAGCCCTTGGCTTCTGCTTCAAACCCTCAAGAGGGGAAGCAACTCCGTGTGCC


TGGGGTTCCCGAGGGAGCTGCTGGCTGACCTGGGCCCACAGAGCCTGGCTTTGGTCCCCAGCATTGCAGTATGGTGTGGTGTTTGTA


GGCTGTGGGGTCTGGCTGTGTGGCCAAGGTGAATAGCACAGGTTAGGGTGTGTGCCACACCCCATGCACCTCAGGGCCAAGCGGGGG


CGTGGCTGGCCTTTCAGGTCCAGGCCAGTGGGCCTGGTAGCACATGTCTGTCCTCAGAGCAGGGGCCAGATGATTTTCCTCCCTGGT


TTGCAGCTGTTTTCAAGCCCCCGATAATCGCTCTTTTCCACTCCAAGATGCCCTCATAAACCAATGTGAGCAAGACTACTGGACTTC


TATCAATGGTACTCTAATCAGTCCTTATTATCCCAGCTTGCTGAGGGGCAGGGAGAGCGCCTCTTCCTCTGOGCAGCGCTATCTAGA


TAGGTAAGTGGGGGCGGGGAAGGGTGCATAGCTGTTTTAGCTGAGGGACGTGGTGCCGACGTCCCCAAACCTAGCTAGGCTAAGTCA


AGATCAACATTCCAGGGTTGGTAATGTTGGATGATGAAACATTCATTTTTACCTTGTGGATGCTAGTGCTGTAGAGTTCACTGTTGT


ACACAGTCTGTTTTCTATTTGTTAAGAAAAACTACAGCATCATTGCATAATTCTTGATGGTAATAAATTTGAATAATCAGATTTCTT


AC





HUMAN PROTEIN SEQUENCE: hP28-021.3 (Seq ID No: 72)


MAPEPAPGRTMVPLVPALVGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRPGVIAAEFDDGA


GSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLP


VDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMP


YVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVT


YYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWE


PPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEV


ESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQsTPSAP


PQKVNCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAMTDVGPGPES


SPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQNGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETT


YSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTANNTALLQWEPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTV


TGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQN


ITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTTPVEQVFAKNFRVAAANKTSVLLSWEVPDSYKSAVPFKILYNGQSV


EVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPID


RVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLAS


LKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTCPVLAVILIILIVIAILLFKKARTHSPSSKDEQSIGLKDSLLANSSDPV


EMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVP


GSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMNTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATY


TVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVD


IYGNVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHQKLGQVPPGESWTANELEFKLLASSKAIITSRFISANLP


CNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRNLWEHNSTIIVMLTKLREMGREKC


HQYWPAERSARYQYFVVDPMAEYNNPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPIT


VHCSAGVGRTGVPITLSIVLERMRYEGVVDMFQTVKTLRTQRPANVQTEDQYQLCYRAALEYLGSFDHYAT*





HUMAN mRNA SEQUENCE: hR28-021.4 (Seq ID No: 73)


GCGTGTGTGGACTGAAACCCAAAAGCCAGAAACTCTCTGCATGTGTCCCTCATGGAGCCATATGGTCTCTAGTCTCTGTTTTTCAAA


ATTTGCAGGACTGATGACTGATTGGACAGTGGTGCAGGAGGGAAGGTCTCTGCATGTCAGTGATTAAATTGCTGAAGATGCCACTGC


CTGAGACGGGCAGTATTGAAGGAAGGAGTGGAGGCCCTGGTGCCCGGCCCTTGGTGCTGAGTATCCAGCAAGAGTGACCGGGGTGAA


GAAGCAAAGACTCGGTTGATTGTCCTGGGCTGTGGCTGGCTGTGGAGCTAGAGCCCTGGATGGCCCCTGAGCCAGCCCCAGGGAGGA


CGATGGTGCCCCTTGTGCCTGCACTGGTGATGCTTGGTTTGGTGGCAGGCGCCCATGGTGACAGCAAACCTGTCTTCATTAAAGTCC


CTGAGGACCAGACTGGGCTGTCAGGAGGGGTAGCCTCCTTCGTGTGCCAAGCTACAGGAGAACCCAAGCCGCGCATCACATGGATGA


AGAAGGGGAAGAAAGTCAGCTCCCAGCGCTTCGAGGTCATTGAGTTTGATGATGGGGCAGGGTCAGTGCTTCGGATCCAGCCATTGC


GGGTCCAGCGAGATGAAGCCATCTATGAGTGTACAGCTACTAACAGCCTGGGTGAGATCAACACTAGTGCCAAGCTCTCAOTGCTCG


AAGAGGAACAGCTGCCCCCTGGGTTCCCTTCCATCGACATGGGGCCTCAGCTGAAGGTGGTGGAGAAGGCACGCACAGCCACCATGC


TATGTGCCGCAGGCGGAAATCCAGACCCTGAGATTTCTTGGTTCAAGGACTTCCTTCCTGTAGACCCTGCCACGAGCAACGGCCGCA


TCAAGCAGCTGCGTTCAGGTGCCTTGCAGATAGAGAGCAGTGAGGAATCCGACCAAGGCAAGTACGACTGTGTGGCGACCAACTCGG


CAGGCACACGTTACTCAGCCCCTGCGAACCTGTATGTGCGAGTGCGCCGCGTGGCTCCTCGTTTCTCCATCCCTCCCAGCAGCCAGG


AGGTGATGCCAGGCGGCAGCGTGAACCTGACATGCGTGGCAGTGGGTGCACCCATGCCCTACGTGAAGTGGATGATGGGGGCCGAGG


AGCTCACCAAGGAGGATGAGATGCCAGTTGGCCGCAACGTCCTGGAGCTCAOCAATGTCGTACGCTCTGCCAACTACACCTGTGTGG


CCATCTCCTCGCTGGGCATGATCGAGGCCACAGCCCAGGTCACAGTGAAAGCTCTTCCAAAGCCTCCGATTGATCTTGTGOTGACAG


AGACAACTGCCACCAGTGTCACCCTCACCTGGGACTCTGGGAACTCGGAGCCTGTAACCTACTATGGCATCCAGTACCGCGCAGCGG


GCACGGAGGGCCCCTTTCAGGAGGTGGATGGTGTGGCCACCACCCGCTACAGCATTGGCGGCCTCAGCCCTTTCTCGGAATATGCCT


TCCGCGTGCTGGCGGTGAACAGCATCGGGCGAGGGCCGCCCAGCGAGGCAGTGCGGGCACGCACGGGAGAACAGGCGCCCTCCAGCC


CACCGCGCCGCGTGCAGGCACGCATGCTGAGCGCCAGCACCATGCTGGTGCAGTGGGAGCCTCCCGAGGAGCCCCCCGGCCTGGTGC


GGGGATACCGCGTCTACTATACTCCGGACTCCCGCCGCCCCCCGAACGCCTGGCACAAGCACAACACCGACGCGGGGCTCCTCACGA


CCGTGGGCAGCCTGCTGCCTGGCATCACCTACAGCCTGCGCGTGCTTGCCTTCACCGCCGTGGGCGATGGCCCTCCCAGCCCCACCA


TCCAGGTCAAGACGCAGCAGGGAGTGCCTCCCCAGCCCGCGGACTTCCAGGCCGAGGTGGAGTCGGACACCAGGATCCAGCTCTCGT


GGCTGCTGCCCCCTCAGGAGCGGATCATCATGTATGAACTGGTGTACTGGGCGGCAGAGGACGAAGACCAACAGCACAAGGTGACCT


TCGACCCAACCTCCTCCTACACACTAGAGGACCTGAAGCCTGACACACTCTACCGCTTCCAGCTGGCTGCACGCTCGGATATGGGGG


TGGGCGTCTTCACCCCCACCATTGAGGCCCGCACAGCCCAGTCCACCCCCTCCGCCCCTCCCCAGAAGGTGATGTGTGTGAGCATGG


GCTCCACCACGGTCCGGGTAAGTTGGGTCCCGCCGCCTGCCGACAGCCGCAACGGCGTTATCACCCAGTACTCCGTGGCCTACGAGG


CGGTGGACGGCGAGGACCGCGGGCGGCATGTGGTGGATGGCATCAGCCGTGAGCACTCCAGCTGGGACCTGGTGGGCCTGGAGAAGT


GGACGGAGTACCGGGTGTGGGTGCGGGCACACACAGACGTGGGCCCCGGCCCCGAGAGCAGCCCGGTGCTGGTGCGCACCGATGAGG


ACGTGCCCAGCGGGCCTCCGCGGAAGGTGGAGGTGGAGCCACTGAACTCCACTGCTGTGCATGTCTACTGGAAGCTGCCTGTCCCCA


GCAAGCAGCATGGCCAGATCCGCGGCTACCAGGTCACCTACGTGCGGCTGGAGAATGGCGAGCCCCGTGGACTCCCCATCATCCAAG


ACGTCATGCTAGCCGAGGCCCAGTGGCGGCCAGAGGACTCCGAGGACTATGAAACCACTATCAGCGGCCTGACCCCGGAGACCACCT


ACTCCGTTACTGTTGCTGCCTATACCACCAAGGGGGATGGTGCCCGCAGCAAGCCCAAAATTGTCACTACAACAGGTGCAGTCCCAG


GCCGGCCCACCATGATGATCAGCACCACGCCCATGAACACTGCGCTGCTCCAGTGGCACCCACCCAAGGAACTGCCTGGCGAGCTGC


TGGGCTACCGGCTGCAGTACTGCCGGGCCGACGAGGCGCGGCCCAACACCATAGATTTCGGCAAGGATGACCAGCACTTCACAGTCA


CCGGCCTGCACAAGGGGACCACCTACATCTTCCGGCTTGCTGCCAAGAACCGGGCTGGCTTGGGTGAGGAGTTCGAGAAGGAGATCA


GGACCCCCGAGGACCTGCCCAGCGGCTTCCCCCAAAACCTGCATGTGACAGGACTGACCACGTCTACCACAGAACTGGCCTGGGACC


CGCCAGTGCTGGCGGAGAGGAACGGGCGCATCATCAGCTACACCGTGGTGTTCCGAGACATCAACAGCCAACAGGAGCTGCAGAACA


TCACGACAGACACCCGCTTTACCCTTACTGGCCTCAAGCCAGACACCACTTACGACATCAAGGTCCGCGCATGGACCAGCAAAGGCT


CTGGCCCACTCAGCCCCAGCATCCAGTCCCGGACCATGCCGGTGGAGCAAGTGTTTGCCAAGAACTTCCGGGTGGCGGCTGCAATGA


AGACGTCTGTGCTGCTCAGCTGGGAGGTTCCCGACTCCTATAAGTCAGCTGTGCCCTTTAAGATTCTGTACAATGGGCAGAGTGTGG


AGGTGGACGGGCACTCGATGCGGAAGCTGATCGCAGACCTGCAGCCCAACACAGAGTACTCGTTTGTGCTGATGAACCGTGGCAGCA


GCGCAGGGGGCCTGCAGCACCTGGTGTCCATCCGCACAGCCCCCGACCTCCTGCCTCACAAGCCGCTGCCTGCCTCTGCCTACATAG


AGGACGGCCGCTTCGATCTCTCCATGCCCCATGTGCAAGACCCCTCGCTTGTCAGGTGGTTCTACATTGTTGTGGTACCCATTGACC


GTGTGGGCGGGAGCATGCTGACGCCAAGGTGGAGCACACCCGAGGAACTGGAGCTGGACGAGCTTCTAGAAGCCATCGAGCAAGGCG


GAGAGGAGCAGCGGCGGCGGCGGCGGCAGGCAGAACGTCTGAAGCCATATGTGGCTGCTCAACTGGATGTGCTCCCGGAGACCTTTA


CCTTGGGGGACAAGAAGAACTACCGGGGCTTCTACAACCGGCCCCTGTCTCCGGACTTGAGCTACCAGTGCTTTGTGCTTGCCTCCT


TGAAGGAACCCATGGACCAGAAGCGCTATGCCTCCAGCCCCTACTCGGATGAGATCGTGGTCCAGGTGACACCAGCCCAGCAGCAGG


AGGAGCCGGAGATGCTGTGGGTGACGGGTCCCGTGCTGGCAGTCATCCTCATCATCCTCATTGTCATCGCCATCCTCTTGTTCAAAA


GGAAAAGGACCCACTCTCCGTCCTCTAAGGATGAGCAGTCGATCGGACTGAAGGACTCCTTGCTGGCCCACTCCTCTGACCCTGTGG


AGATGCGGAGGCTCAACTACCAGACCCCAGGTATGCGAGACCACCCACCCATCCCCATCACCGACCTGGCGGACAACATCGAGCGCC


TCAAAGCCAACGATGGCCTCAAGTTCTCCCAGGAGTATGAGTCCATCGACCCTGGACAGCAGTTCACGTGGGAGAATTCAAACCTGG


AGGTGAACAAGCCCAAGAACCGCTATGCGAATGTCATCGCCTACGACCACTCTCGAGTCATCCTTACCTCTATCGATGGCGTCCCCG


GGAGTGACTACATCAATGCCAACTACATCGATGGCTACCGCAAGCAGAATGCCTACATCGCCACGCAGGGCCCCCTGCCCGAGACCA


TGGGCGATTTCTGGAGAATGGTGTGGGAACAGCGCACGGCCACTGTGGTCATGATGACACGGCTGGAGGAGAAGTCCCGGGTAAAAT


GTGATCAGTACTGGCCAGCCCGTGGCACCGAGACCTGTGGCCTTATTCAGGTGACCCTGTTGGACACAGTGGAGCTGGCCACATACA


CTGTGCGCACCTTCGCACTCCACAAGAGTGGCTCCAGTGAGAAGCGTGACCTGCGTCAGTTTCAGTTCATGGCCTGGCCAGACCATG


GAGTTCCTGAGTACCCAACTCCCATCCTGGCCTTCCTACGACGGGTCAAGGCCTGCAACCCCCTAGACGCAGGGCCCATGGTGGTGC


ACTGCAGCGCGGGCGTGGGCCGCACCGGCTGCTTCATCGTGATTGATGCCATGTTGGAGCGGATGAAGCACGAGAAGACGGTGGACA


TCTATGGCCACGTGACCTGCATGCGATCACAGAGGAACTACATGGTGCAGACGGAGGACCAGTACGTGTTCATCCATGAGGCGCTGC


TGGAGGCTGCCACGTGCGGCCACACAGAGGTGCCTGCCCGCAACCTGTATGCCCACATCCAGAAGCTGGGCCAAGTGCCTCCAGGGG


AGAGTGTGACCGCCATGGAGCTCGAGTTCAAGTTGCTGGCCAGCTCCAAGGCCCACACGTCCCGCTTCATCAGCGCCAACCTGCCCT


GCAACAAGTTCAAGAACCGGCTGGTGAACATCATGCCCTACGAATTGACCCGTGTGTGTCTGCAGCCCATCCGTGGTGTGGAGGGCT


CTGACTACATCAATGCCAGCTTCCTGGATGGTTATAGACAGCAGAAGGCCTACATAGCTACACAGGGGCCTCTGGCAGAGAGCACCG


AGGACTTCTGGCGCATGCTATGGGAGCACAATTCCACCATCATCGTCATGCTGACCAAGCTTCGGGAGATGGGCAGGGAGAAATGCC


ACCAGTACTGGCCAGCAGAGCGCTCTGCTCGCTACCAGTACTTTGTTGTTGACCCGATGGCTGAGTACAACATGCCCCAGTATATCC


TGCGTGAGTTCAAGGTCACGGATGCCCGGGATGGGCAGTCAAGGACAATCCGGCAGTTCCAGTTCACAGACTGGCCAGAGCAGGGCG


TGCCCAAGACAGGCGAGGGATTCATTGACTTCATCGGGCAGGTGCATAAGACCAAGGAGCAGTTTGGACAGGATGGGCCTATCACGG


TGCACTGCAGTGCTGGCGTGGGCCGCACCGGGGTGTTCATCACTCTGAGCATCGTCCTGGAGCGCATGCGCTACGAGGGCGTGGTCG


ACATGTTTCAGACCGTGAAGACCCTGCGTACACAGCGTCCTGCCATGGTGCAGACAGAGGACCAGTATCAGCTGTGCTACCGTGCGG


CCCTGGAGTACCTCGGCAGCTTTGACCACTATGCAACGTAACTACCGCTCCCCTCTCCTCCGCCACCCCCGCCGTGGGGCTCCGGAG


GGACCCAGCTCCTCTGAGCCATACCGACCATCGTCCAGCCCTCCTACGCAGATGCTGTCACTGGCAGAGCACAGCCCACGGGAGATC


ACAGCGTTTCAGGAACGTTGCCACACCAATCAGAGAGCCTAGAACATCCCTGGGCAAGTGGATGGCCCAGCAGGCAGGCACTGTGGC


CCTTCTGTCCACCAGACCCACCTGGAGCCCGCTTCAAGCTCTCTGTTGCGCTCCCGCATTTCTCATGCTTCTTCTCATGGGGTGGGG


TTGGGGCAAAGCCTCCTTTTTAATACATTAAGTGGGGTAGACTGAGGGATTTTAGCCTCTTCCCTCTGATTTTTCCTTTCGCGAATC


CGTATCTGCAGAATGGGCCACTGTAGGGGTTGGGGTTTATTTTGTTTTGTTTTTTTTTTTCTTGATTTGTATGACTTCTGCTGAAGG


ACAGAACATTGCCTTCCTCGTGCAGAGCTGGGGCTGCCAGCCTGAGCGGAGGCTCGGCCGTGGGCCGGGAGGCAGTGCTGATCCGGC


TGCTCCTCCAGCCCTTCAGACGAGATCCTGTTTCAGCTAAATGCAGGGAAACTCAATGTTTTTTTAAGTTTTGTTTTCCCTTTAAAG


CCTTTTTTTAGGCCACATTGACAGTGGTGGGCGGGGAGAAGATAGGGAACACTCATCCCTGGTCGTCTATCCCAGTGTGTGTTTAAC


ATTCACAGCCCAGAACCACAGATGTGTCTGGGAGAGCCTGGCAAGGCATTCCTCATCACCATCGTGTTTGCAAAGGTTAAAACAAAA


ACAAAAAACCACAAAAATAAAAAACAAAAAAAACAAAAAACCCAAGAAAAAAAAAAAGAGTCAGCCCTTGGCTTCTGCTTCAAACCC


TCAAGAGGGGAAGCAACTCCGTGTGCCTGGGGTTCCCGAGGGAGCTGCTGCCTGACCTGGGCCCACAGAGCCTGGCTTTGGTCCCCA


GCATTGCAGTATGGTGTGGTGTTTGTAGGCTGTGGGGTCTGGCTGTGTGGCCAAGGTGAATAGCACAGGTTAGGGTGTGTGCCACAC


CCCATGCACCTCAGCGCCAAGCGGGGGCGTGGCTGGCCTTTCAGGTCCAGGCCAGTGGGCCTGGTAGCACATGTCTGTCCTCAGAGC


AGGGGCCAGATGATTTTCCTCCCTGGTTTGCAGCTGTTTTCAAAGCCCCCGATAATCGCTCTTTTCCACTCCAAGATGCCCTCATAA


ACCAATGTGGCAAGACTACTGGACTTCTATCAATGGTACTCTAATCAGTCCTTATTATCCCAGCTTGCTGAGGGGCAGGGAGAGCGC


CTCTTCCTCTGGGCAGCGCTATCTAGATAGGTAAGTGGGGGCGGGGAAGGGTGCATAGCTGTTTTAGCTGAGGGACGTGGTGCCGAC


GTCCCCAAACCTAGCTAGGCTAAGTCAAGATCAACATTCCAGGGTTGGTAATGTTGGATGATGAAACATTCATTTTTACCTTGTGGA


TGCTAGTGCTGTAGAGTTCACTGTTGTACACAGTCTGTTTTCTATTTGTTAAGAAAAACTACAGCATCATTGCATAATTCTTGATGG


TAATAAATTTGAATAATCAGATTTCTTAC





HUMAN PROTEIN SEQUENCE hP28-021.4 (Seq ID No: 74)


MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIAEFDDGA


GSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLP


VDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMP


YVKWMGAEELTKEDEMPVGRNVLELSNVVPSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTAWDSGNSEPVT


YYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWE


PPEEPNGLVRGYNVYYTPDSRRPPMAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEV


ESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAP


PQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPES


SPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLNGEPRGLPIIQDVHMLAEAQWRPEESEDYETT


ISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTANNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDF


GKDDQHFTVTGLNKGTTYIFRLAANRAGLGEEFEKEIRTPAADLPSGFPQNLHVTGLTTSTTALAWDPPVLAERNGRIISYTVVFRD


INSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPF


KILYNGQSVEVDGHSMRKLIANLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSTPHVQDPSLVRW


FYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQANRLKPYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDL


SYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDAQSIGLKDS


LLAHSSDPVEMRRLNYQTPGMRNHPPIPUTDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRV


ILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGETCGLAIQVTL


LDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDANLE


RMKHEKTVDIYGHVTCMRSQRNYNVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHT


SRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTK


LREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVMKTKE


QFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPANVQTEDQYQLCYRAALEYLGSFDHYAT*









The mouse and human genomic DNA sequence, sequence corresponding to the mRNA(s) generated therefrom and amino acid sequences of the proteins as shown in Tables 1-7 are described according to SEQ ID NOS as follows in Table 8.

TABLE 8DESIGNATIONSEQ ID NOTYPE OF SEQUENCEmD22-022SEQ ID NO: 1MOUSE GENOMIC SEQUENCEmR22-022.1SEQ ID NO: 2MOUSE mRNA SEQUENCEmP22-022.1SEQ ID NO: 3MOUSE PROTEIN SEQUENCEmR22-022.2SEQ ID NO: 4MOUSE mRNA SEQUENCEmP22-022.2SEQ ID NO: 5MOUSE PROTEIN SEQUENCEhD22-022SEQ ID NO: 6HUMAN GENOMIC SEQUENCEhR22-022.1SEQ ID NO: 7HUMAN mRNA SEQUENCEhP22-022.1SEQ ID NO: 8HUMAN PROTEIN SEQUENCEhR22-022.2SEQ ID NO: 9HUMAN mRNA SEQUENCEhP22-022.2SEQ ID NO: 10HUMAN PROTEIN SEQUENCEmD27-007SEQ ID NO: 11MOUSE GENOMIC SEQUENCEmR27-007.1SEQ ID NO: 12MOUSE mRNA SEQUENCEmP27-007.1SEQ ID NO: 13MOUSE PROTEIN SEQUENCEmR27-007.2SEQ ID NO: 14MOUSE mRNA SEQUENCEmP27-007.2SEQ ID NO: 15MOUSE PROTEIN SEQUENCEhD27-007SEQ ID NO: 16HUMAN GENOMIC SEQUENCEhR27-007.1SEQ ID NO: 17HUMAN mRNA SEQUENCEhP27-007.1SEQ ID NO: 18HUMAN PROTEIN SEQUENCEhR27-007.2SEQ ID NO: 19HUMAN mRNA SEQUENCEhP27-007.2SEQ ID NO: 20HUMAN PROTEIN SEQUENCEhR27-007.3SEQ ID NO: 21HUMAN mRNA SEQUENCEhP27-007.3SEQ ID NO: 22HUMAN PROTEIN SEQUENCEmD27-009SEQ ID NO: 23MOUSE GENOMIC SEQUENCEmR27-009.1SEQ ID NO: 24MOUSE mRNA SEQUENCEmP27-009.1SEQ ID NO: 25MOUSE PROTEIN SEQUENCEhD27-009SEQ ID NO: 26HUMAN GENOMIC SEQUENCEhR27-009.1SEQ ID NO: 27HUMAN mRNA SEQUENCEhP27-009.1SEQ ID NO: 28HUMAN PROTEIN SEQUENCEhR27-009.2SEQ ID NO: 29HUMAN mRNA SEQUENCEhP27-009.2SEQ ID NO: 30HUMAN PROTEIN SEQUENCEmD27-014SEQ ID NO: 31MOUSE GENOMIC SEQUENCEmR27-014.1SEQ ID NO: 32MOUSE mRNA SEQUENCEmP27-014.1SEQ ID NO: 33MOUSE PROTEIN SEQUENCEmR27-014.2SEQ ID NO: 34MOUSE mRNA SEQUENCEmP27-014.2SEQ ID NO: 35MOUSE PROTEIN SEQUENCEmR27-014.3SEQ ID NO: 36MOUSE mRNA SEQUENCEmP27-014.3SEQ ID NO: 37MOUSE PROTEIN SEQUENCEmR27-014.4SEQ ID NO: 38MOUSE mRNA SEQUENCEmP27-014.4SEQ ID NO: 39MOUSE PROTEIN SEQUENCEhD27-014SEQ ID NO: 40HUMAN GENOMIC SEQUENCEhR27-014.1SEQ ID NO: 41HUMAN mRNA SEQUENCEhP27-014.1SEQ ID NO: 42HUMAN PROTEIN SEQUENCEhR27-014.2SEQ ID NO: 43HUMAN mRNA SEQUENCEhP27-014.2SEQ ID NO: 44HUMAN PROTEIN SEQUENCEhR27-014.3SEQ ID NO: 45HUMAN mRNA SEQUENCEhP27-014.3SEQ ID NO: 46HUMAN PROTEIN SEQUENCEhR27-014.4SEQ ID NO: 47HUMAN mRNA SEQUENCEhP27-014.4SEQ ID NO: 48HUMAN PROTEIN SEQUENCEmD28-002SEQ ID NO: 49MOUSE GENOMIC SEQUENCEmR28-002.1SEQ ID NO: 50MOUSE mRNA SEQUENCEmP28-002.1SEQ ID NO: 51MOUSE PROTEIN SEQUENCEhD28-002SEQ ID NO: 52HUMAN GENOMIC SEQUENCEhR28-002.1SEQ ID NO: 53HUMAN mRNA SEQUENCEhP28-002.1SEQ ID NO: 54HUMAN PROTEIN SEQUENCEmD28-010SEQ ID NO: 55MOUSE GENOMIC SEQUENCEmR28-010.1SEQ ID NO: 56MOUSE mRNA SEQUENCEmP28-010.1SEQ ID NO: 57MOUSE PROTEIN SEQUENCEmR28-010.2SEQ ID NO: 58MOUSE mRNA SEQUENCEmP28-010.2SEQ ID NO: 59MOUSE PROTEIN SEQUENCEhD28-010SEQ ID NO: 60HUMAN GENOMIC SEQUENCEhR28-010.1SEQ ID NO: 61HUMAN mRNA SEQUENCEhP28-010.1SEQ ID NO: 62HUMAN PROTEIN SEQUENCEmD28-021SEQ ID NO: 63MOUSE GENOMIC SEQUENCEmR28-021.1SEQ ID NO: 64MOUSE mRNA SEQUENCEmP28-021.1SEQ ID NO: 65MOUSE PROTEIN SEQUENCEhD28-021SEQ ID NO: 66HUMAN GENOMIC SEQUENCEhR28-021.1SEQ ID NO: 67HUMAN mRNA SEQUENCEhP28-021.1SEQ ID NO: 68HUMAN PROTEIN SEQUENCEhR28-021.2SEQ ID NO: 69HUMAN mRNA SEQUENCEhP28-021.2SEQ ID NO: 70HUMAN PROTEIN SEQUENCEhR28-021.3SEQ ID NO: 71HUMAN mRNA SEQUENCEhP28-021.3SEQ ID NO: 72HUMAN PROTEIN SEQUENCEhR28-021.4SEQ ID NO: 73HUMAN mRNA SEQUENCEhP28-021.4SEQ ID NO: 74HUMAN PROTEIN SEQUENCE


The CA sequences were analyzed by Panther™ (Molecular Diagnostics, Palo Alto, Calif.) software designed to detect homologs and enable prediction of molecular function through a system for protein functional classification. Human Gene Ontlogy annotations were prepared in accordance with the Gene Ontology Consortium (Gene Ontology: tool for the unification of biology. The Gene Ontology Consortium Nature Genet. 25: 25-29 (2000)). Similar analysis was carried out by determining IPR information regarding the CA polypeptides from InterPro, which is an integrated documentation resource for protein families, domains and functional sites (Apweiler at al. Bioinformatics 16(12):1145-1150 (2000)).


The CA sequences may be classified according to the following predicted general classifications of function by Panther™ analysis, human gene ontology and IPR domain information for polypeptides having SEQ ID NOS: 8, 10, 18, 20, 22, 28, 30, 42, 44, 46, 48, 54, 62, 68, 70, 72 and 74 as shown in Tables 1-7. The classifications are shown in Table 9 below. The biological function of a CA protein comprises a function shown in Table 9 below.

TABLE 9Human ProteinSEQ ID NO:FUNCTIONhP22-022.1SEQ ID NO: 8HUMAN PANTHER CLASSIFICATIONSFAMILY (SUBFAMILY)SHORT-CHAIN DEHYDROGENASE-RELATED(FOLLICULAR VARIANTTRANSLOCATION PROTEIN 1)BIOLOGICAL PROCESSBiological processunclassified(2.99.00.00.00)MOLECULAR FUNCTIONSOxidoreductase(1.19.00.00.00) > Reductase(1.19.06.00.00)Oxidoreductase(1.19.00.00.00) > Dehydrogenase(1.19.05.00.00)HUMAN GENE ONTOLOGYNo Gene OntologyHUMAN PROTEIN DOMAINS (INTERPROSIGNATURES)IPR002198 (SDRFAMILY)IPR002347 (GDHRDH)IPR002198 (adh short)hP22-022.2SEQ ID NO: 10HUMAN PANTHER CLASSIFICATIONSFAMILY (SUBFAMILY)SHORT-CHAIN DEHYDROGENASE-RELATED(FOLLICULAR VARIANTTRANSLOCATION PROTEIN 1)BIOLOGICAL PROCESSBiological processunclassified(2.99.00.00.00)MOLECULAR FUNCTIONSOxidoreductase(1.19.00.00.00) > Reductase(1.19.06.00.00)Oxidoreductase(1.19.00.00.00) > Dehydrogenase(1.19.05.00.00)HUMAN GENE ONTOLOGYNo Gene OntologyHUMAN PROTEIN DOMAINS (INTERPROSIGNATURES)IPR002198 (SDRFAMILY)IPR002347 (GDHRDH)IPR002198 (adh short)hP27-007.1SEQ ID NO: 18HUMAN PANTHER CLASSIFICATIONSFAMILY (SUBFAMILY)PLATELET ENDOTHELIAL CELLADHESION MOLECULE (PECAM-1)(SH2DOMAIN-CONTAINING PHOSPHATASEANCHOR PROTEIN 1-RELATED)BIOLOGICAL PROCESSBiological processunclassified(2.99.00.00.00)MOLECULAR FUNCTIONSMolecular functionunclassified(1.97.00.00.00)HUMAN GENE ONTOLOGYBIOLOGICAL PROCESSphagocytosis > phagocytosis, engulfmentdefence response > immune responseMOLECULAR FUNCTIONGO molecular function > cell adhesiondefense/immunity protein > immunoglobulinB cell receptor > immunoglobulinCELL COMPONENTcell > membrane fractioncell > plasma membraneHUMAN PROTEIN DOMAINS (INTERPROSIGNATURES)IPR003598 (IGc2)IPR003599 (IG)IPR003006 (ig)hP27-007.2SEQ ID NO: 20HUMAN PANTHER CLASSIFICATIONSFAMILY (SUBFAMILY)PLATELET ENDOTHELIAL CELLADHESION MOLECULE (PECAM-1)(SH2DOMAIN-CONTAINING PHOSPHATASEANCHOR PROTEIN 1-RELATED)BIOLOGICAL PROCESSBiological processunclassified(2.99.00.00.00)MOLECULAR FUNCTIONSMolecular functionunclassified(1.97.00.00.00)HUMAN GENE ONTOLOGYBIOLOGICAL PROCESSdefence response > immune responsephagocytosis > phagocytosis, engulfmentMOLECULAR FUNCTIONdefense/immunity protein > immunoglobulinB cell receptor > immunoglobulinGO molecular function > cell adhesionCELL COMPONENTcell > membrane fractioncell > plasma membraneHUMAN PROTEIN DOMAINS (INTERPROSIGNATURES)IPR003598 (IGc2)IPR003599 (IG)IPR003006 (ig)hP27-007.3SEQ ID NO: 22HUMAN PANTHER CLASSIFICATIONSFAMILY (SUBFAMILY)PLATELET ENDOTHELIAL CELLADHESION MOLECULE (PECAM-1)(SH2DOMAIN-CONTAINING PHOSPHATASEANCHOR PROTEIN 1-RELATED)BIOLOGICAL PROCESSBiological processunclassified(2.99.00.00.00)MOLECULAR FUNCTIONSMolecular functionunclassified(1.97.00.00.00)HUMAN GENE ONTOLOGYBIOLOGICAL PROCESSphagocytosis > phagocytosis, engulfmentdefence response > immune responseMOLECULAR FUNCTIONGO molecular function > cell adhesiondefense/immunity protein > immunoglobulinB cell receptor > immunoglobulinCELL COMPONENTcell > membrane fractioncell > plasma membraneHUMAN PROTEIN DOMAINS (INTERPROSIGNATURES)IPR003598 (IGc2)IPR003599 (IG)IPR003006 (ig)hP27-009.1SEQ ID NO: 28HUMAN PANTHER CLASSIFICATIONSFAMILY (SUBFAMILY)CF10153(POTASSIUMINTERMEDIATE/SMALL CONDUCTANCECALCIUM-ACTIVATED CHANNEL)BIOLOGICAL PROCESSTransport(2.15.00.00.00) > Iontransport(2.15.01.00.00) > Cationtransport(2.15.01.01.00)Neuronal activities(2.18.00.00.00) > Synaptictransmission(2.18.01.00.00)MOLECULAR FUNCTIONSIon channel(1.03.00.00.00) > Voltage-gated ion channel(1.03.03.00.00) > Voltage-gatedpotassium channel(1.03.03.03.00)HUMAN GENE ONTOLOGYNo Gene OntologyHUMAN PROTEIN DOMAINS (INTERPROSIGNATURES)IPR003931 (SK channel)IPR000694 (PRO RICH)NULL (GLN RICH)hP27-009.2SEQ ID NO: 30HUMAN PANTHER CLASSIFICATIONSFAMILY (SUBFAMILY)CF10153(POTASSIUMINTERMEDIATE/SMALL CONDUCTANCECALCIUM-ACTIVATED CHANNEL)BIOLOGICAL PROCESSTransport(2.15.00.00.00) > Iontransport(2.15.01.00.00) > Cationtransport(2.15.01.01.00)Neuronal activities(2.18.00.00.00) > Synaptictransmission(2.18.01.00.00)MOLECULAR FUNCTIONSIon channel(1.03.00.00.00) > Voltage-gated ion channel(1.03.03.00.00) > Voltage-gatedpotassium channel(1.03.03.03.00)HUMAN GENE ONTOLOGYNo Gene OntologyHUMAN PROTEIN DOMAINS (INTERPROSIGNATURES)IPR003931 (SKCHANNEL)IPR004178 (CaMBD)IPR003931 (SK channel)IPR000694 (PRO RICH)NULL (GLN RICH)IPR001622 (CHANNEL PORE K)hP27-014.1SEQ ID NO: 42HUMAN PANTHER CLASSIFICATIONSFAMILY (SUBFAMILY)MACROPHAGE COLONYSTIMULATING FACTOR-1(MACROPHAGECOLONY STIMULATING FACTOR-1)BIOLOGICAL PROCESSImmunity and defense(2.16.00.00.00) > Macrophage-mediated immunity(2.16.05.00.00)Immunity and defense(2.16.00.00.00) > Granulocyte-mediated immunity(2.16.04.00.00)Developmental processes(2.23.00.00.00) > Mesodermdevelopment(2.23.10.00.00) > Hematopoesis(2.23.10.06.00)MOLECULAR FUNCTIONSSignaling molecule(1.02.00.00.00) > Cytokine(1.02.01.00.00) > Othercytokine(1.02.01.99.00)HUMAN GENE ONTOLOGYNo Gene OntologyHUMAN PROTEIN DOMAINS (INTERPROSIGNATURES)No Domain HithP27-014.2SEQ ID NO: 44HUMAN PANTHER CLASSIFICATIONSFAMILY (SUBFAMILY)MACROPHAGE COLONYSTIMULATING FACTOR-1(MACROPHAGECOLONY STIMULATING FACTOR-1)BIOLOGICAL PROCESSImmunity and defense(2.16.00.00.00) > Macrophage-mediated immunity(2.16.05.00.00)Immunity and defense(2.16.00.00.00) > Granulocyte-mediated immunity(2.16.04.00.00)Developmental processes(2.23.00.00.00) > Mesodermdevelopment(2.23.10.00.00) > Hematopoesis(2.23.10.06.00)MOLECULAR FUNCTIONSSignaling molecule(1.02.00.00.00) > Cytokine(1.02.01.00.00) > Othercytokine(1.02.01.99.00)HUMAN GENE ONTOLOGYNo Gene OntologyHUMAN PROTEIN DOMAINS (INTERPROSIGNATURES)No Domain HithP27-014.3SEQ ID NO: 46HUMAN PANTHER CLASSIFICATIONSFAMILY (SUBFAMILY)MACROPHAGE COLONYSTIMULATING FACTOR-1(Unassigned)BIOLOGICAL PROCESSImmunity and defense(2.16.00.00.00) > Macrophage-mediated immunity(2.16.05.00.00)Immunity and defense(2.16.00.00.00) > Granulocyte-mediated immunity(2.16.04.00.00)Developmental processes(2.23.00.00.00) > Mesodermdevelopment(2.23.10.00.00) > Hematopoesis(2.23.10.06.00)MOLECULAR FUNCTIONSSignaling molecule(1.02.00.00.00) > Cytokine(1.02.01.00.00) > Othercytokine(1.02.01.99.00)HUMAN GENE ONTOLOGYNo Gene OntologyHUMAN PROTEIN DOMAINS (INTERPROSIGNATURES)No Domain HithP27-014.4SEQ ID NO: 48HUMAN PANTHER CLASSIFICATIONSFAMILY (SUBFAMILY)MACROPHAGE COLONYSTIMULATING FACTOR-1(MACROPHAGECOLONY STIMULATING FACTOR-1)BIOLOGICAL PROCESSImmunity and defense(2.16.00.00.00) > Macrophage-mediated immunity(2.16.05.00.00)Immunity and defense(2.16.00.00.00) > Granulocyte-mediated immunity(2.16.04.00.00)Developmental processes(2.23.00.00.00) > Mesodermdevelopment(2.23.10.00.00) > Hematopoesis(2.23.10.06.00)MOLECULAR FUNCTIONSSignaling molecule(1.02.00.00.00) > Cytokine(1.02.01.00.00) > Othercytokine(1.02.01.99.00)HUMAN GENE ONTOLOGYNo Gene OntologyHUMAN PROTEIN DOMAINS (INTERPROSIGNATURES)No Domain HithP28-002.1SEQ ID NO: 54HUMAN PANTHER CLASSIFICATIONSFAMILY (SUBFAMILY)TETRASPANIN-RELATED(TETRASPANIN TSPAN-5)BIOLOGICAL PROCESSCell adhesion(2.29.00.00.00)MOLECULAR FUNCTIONSCell adhesion molecule(1.05.00.00.00) > Othercell adhesion molecule(1.05.99.00.00)HUMAN GENE ONTOLOGYNo Gene OntologyHUMAN PROTEIN DOMAINS (INTERPROSIGNATURES)IPR000301 (TMFOUR)IPR000301 (transmembrane4)IPR000301 (TM4 2)hP28-010.1SEQ ID NO: 62HUMAN PANTHER CLASSIFICATIONSFAMILY (SUBFAMILY)CADHERIN(LIVER-INTESTINE-CADHERIN)BIOLOGICAL PROCESSSignal transduction(2.11.00.00.00) > Cellcommunication(2.11.03.00.00) > Cell adhesion-mediated signaling(2.11.03.01.00)Cell adhesion(2.29.00.00.00)MOLECULAR FUNCTIONSCell adhesion molecule(1.05.00.00.00) > Cadherin(1.05.02.00.00)HUMAN GENE ONTOLOGYBIOLOGICAL PROCESScell adhesion > homophilic cell adhesionneurogenesis > central nervous systemdevelopmenttranscription, DNA-dependent > transcriptionregulationcell death > apoptosispeptidoglycan catabolism > microtubule-based movementmicrotubule-based process > microtubule-based movementnuclear congression > microtubule-basedmovementMOLECULAR FUNCTIONcell adhesion > calcium-dependent celladhesionligand binding or carrier > calcium bindingenzyme > nitric oxide synthaseGO molecular function > cell cycleregulatorCELL COMPONENTcell > membrane fractionmitochondrial membrane > mitochondrialinner membraneGO cellular component > extracellularextracellular > extracellular spaceHUMAN PROTEIN DOMAINS (INTERPROSIGNATURES)IPR002126 (CADHERIN)IPR002126 (CA)IPR002126 (cadherin)IPR002126 (CADHERIN 2 6)hP28-021.1SEQ ID NO: 68HUMAN PANTHER CLASSIFICATIONSFAMILY (SUBFAMILY)CELL ADHESION MOLECULE-RELATED(RECEPTOR PROTEIN TYROSINEPHOSPHATASE)BIOLOGICAL PROCESSProtein metabolism andmodification(2.05.00.00.00) > Proteinmodification(2.05.03.00.00) > Proteinphosphorylation(2.05.03.01.00)Signal transduction(2.11.00.00.00) > Cellsurface receptor mediated signaltransduction(2.11.01.00.00) > Other receptormediated signaling pathway(2.11.01.99.00)MOLECULAR FUNCTIONSReceptor(1.01.00.00.00) > Otherreceptor(1.01.99.00.00)Phosphatase(1.16.00.00.00) > Proteinphosphatase(1.16.01.00.00)HUMAN GENE ONTOLOGYBIOLOGICAL PROCESSprotein modification > proteindephosphorylationenzyme linked receptor protein signalingpathway > transmembrane receptor proteintyrosine phosphatase signaling pathwayisoprenoid catabolism > phosphatemetabolismdefasciculation of neuron > defasciculationof motor neuronenzyme linked receptor protein signalingpathway > transmembrane receptor proteintyrosine kinase signaling pathwayMOLECULAR FUNCTIONenzyme > protein phosphataseprotein phosphatase > protein tyrosinephosphataseprotein tyrosine phosphatase > prenylatedprotein tyrosine phosphataseprotein tyrosine phosphatase > transmembranereceptor protein tyrosinephosphatasetransmembrane receptor > transmembranereceptor protein tyrosine phosphataseprotein tyrosine phosphatase > non-membrane spanning protein tyrosine phosphataseCELL COMPONENTcell > membrane fractioncytoplasm > cytoskeletoncell > plasma membraneplasma membrane > integral plasmamembrane proteincell > soluble fractionHUMAN PROTEIN DOMAINS (INTERPROSIGNATURES)IPR003962 (FNTYPEIII)IPR000242 (PRTYPHPHTASE)IPR000242 (PTPc)IPR003961 (FN3)IPR003598 (IGc2)IPR003599 (IG)IPR003595 (PTPc motif)IPR003961 (fn3)IPR000242 (Y phosphatase)IPR003006 (ig)IPR000387 (TYR PHOSPHATASE 2 2)IPR000242 (TYR PHOSPHATASE PTP2)hP28-021.2SEQ ID NO: 70HUMAN PANTHER CLASSIFICATIONSFAMILY (SUBFAMILY)CELL ADHESION MOLECULE-RELATED(RECEPTOR PROTEIN TYROSINEPHOSPHATASE)BIOLOGICAL PROCESSProtein metabolism andmodification(2.05.00.00.00) > Proteinmodification(2.05.03.00.00) > Proteinphosphorylation(2.05.03.01.00)Signal transduction(2.11.00.00.00) > Cellsurface receptor mediated signaltransduction(2.11.01.00.00) > Other receptormediated signaling pathway(2.11.01.99.00)MOLECULAR FUNCTIONSReceptor(1.01.00.00.00) > Otherreceptor(1.01.99.00.00)Phosphatase(1.16.00.00.00) > Proteinphosphatase(1.16.01.00.00)HUMAN GENE ONTOLOGYBIOLOGICAL PROCESSprotein modification > proteindephosphorylationenzyme linked receptor protein signalingpathway > transmembrane receptor proteintyrosine phosphatase signaling pathwayisoprenoid catabolism > phosphatemetabolismdefasciculation of neuron > defasciculationof motor neuronenzyme linked receptor protein signalingpathway > transmembrane receptor proteintyrosine kinase signaling pathwayMOLECULAR FUNCTIONenzyme > protein phosphataseprotein phosphatase > protein tyrosinephosphataseprotein tyrosine phosphatase > prenylatedprotein tyrosine phosphataseprotein tyrosine phosphatase > transmembranereceptor protein tyrosinephosphatasetransmembrane receptor > transmembranereceptor protein tyrosine phosphataseprotein tyrosine phosphatase > non-membrane spanning protein tyrosine phosphataseCELL COMPONENTcell > membrane fractioncytoplasm > cytoskeletoncell > plasma membraneplasma membrane > integral plasmamembrane proteincell > soluble fractionHUMAN PROTEIN DOMAINS (INTERPROSIGNATURES)IPR003962 (FNTYPEIII)IPR000242 (PRTYPHPHTASE)IPR000242 (PTPc)IPR003961 (FN3)IPR003598 (IGc2)IPR003599 (IG)IPR003595 (PTPc motif)IPR003961 (fn3)IPR000242 (Y phosphatase)IPR003006 (ig)IPR000387 (TYR PHOSPHATASE 2 2)IPR000242 (TYR PHOSPHATASE PTP2)hP28-021.3SEQ ID NO: 72HUMAN PANTHER CLASSIFICATIONSFAMILY (SUBFAMILY)CELL ADHESION MOLECULE-RELATED(RECEPTOR PROTEIN TYROSINEPHOSPHATASE)BIOLOGICAL PROCESSProtein metabolism andmodification(2.05.00.00.00) > Proteinmodification(2.05.03.00.00) > Proteinphosphorylation(2.05.03.01.00)Signal transduction(2.11.00.00.00) > Cellsurface receptor mediated signaltransduction(2.11.01.00.00) > Other receptormediated signaling pathway(2.11.01.99.00)MOLECULAR FUNCTIONSReceptor(1.01.00.00.00) > Otherreceptor(1.01.99.00.00)Phosphatase(1.16.00.00.00) > Proteinphosphatase(1.16.01.00.00)HUMAN GENE ONTOLOGYBIOLOGICAL PROCESSprotein modification > proteindephosphorylationenzyme linked receptor protein signalingpathway > transmembrane receptor proteintyrosine phosphatase signaling pathwayisoprenoid catabolism > phosphatemetabolismdefasciculation of neuron > defasciculationof motor neuronenzyme linked receptor protein signalingpathway > transmembrane receptor proteintyrosine kinase signaling pathwayMOLECULAR FUNCTIONenzyme > protein phosphataseprotein phosphatase > protein tyrosinephosphataseprotein tyrosine phosphatase > prenylatedprotein tyrosine phosphataseprotein tyrosine phosphatase > transmembranereceptor protein tyrosinephosphatasetransmembrane receptor > transmembranereceptor protein tyrosine phosphataseprotein tyrosine phosphatase > non-membrane spanning protein tyrosine phosphataseCELL COMPONENTcell > membrane fractioncytoplasm > cytoskeletoncell > plasma membraneplasma membrane > integral plasmamembrane proteincell > soluble fractionHUMAN PROTEIN DOMAINS (INTERPROSIGNATURES)IPR003962 (FNTYPEIII)IPR000242 (PRTYPHPHTASE)IPR000242 (PTPc)IPR003961 (FN3)IPR003598 (IGc2)IPR003599 (IG)IPR003595 (PTPc motif)IPR003961 (fn3)IPR000242 (Y phosphatase)IPR003006 (ig)IPR000387 (TYR PHOSPHATASE 2 2)IPR000242 (TYR PHOSPHATASE PTP2)hP28-021.4SEQ ID NO: 74HUMAN PANTHER CLASSIFICATIONSFAMILY (SUBFAMILY)CELL ADHESION MOLECULE-RELATED(RECEPTOR PROTEIN TYROSINEPHOSPHATASE)BIOLOGICAL PROCESSProtein metabolism andmodification(2.05.00.00.00) > Proteinmodification(2.05.03.00.00) > Proteinphosphorylation(2.05.03.01.00)Signal transduction(2.11.00.00.00) > Cellsurface receptor mediated signaltransduction(2.11.01.00.00) > Other receptormediated signaling pathway(2.11.01.99.00)MOLECULAR FUNCTIONSReceptor(1.01.00.00.00) > Otherreceptor(1.01.99.00.00)Phosphatase(1.16.00.00.00) > Proteinphosphatase(1.16.01.00.00)HUMAN GENE ONTOLOGYBIOLOGICAL PROCESSprotein modification > proteindephosphorylationenzyme linked receptor protein signalingpathway > transmembrane receptor proteintyrosine phosphatase signaling pathwayisoprenoid catabolism > phosphatemetabolismdefasciculation of neuron > defasciculationof motor neuronenzyme linked receptor protein signalingpathway > transmembrane receptor proteintyrosine kinase signaling pathwayMOLECULAR FUNCTIONenzyme > protein phosphataseprotein phosphatase > protein tyrosinephosphataseprotein tyrosine phosphatase > prenylatedprotein tyrosine phosphataseprotein tyrosine phosphatase > transmembranereceptor protein tyrosinephosphatasetransmembrane receptor > transmembranereceptor protein tyrosine phosphataseprotein tyrosine phosphatase > non-membrane spanning protein tyrosine phosphataseCELL COMPONENTcell > membrane fractioncytoplasm > cytoskeletoncell > plasma membraneplasma membrane > integral plasmamembrane proteincell > soluble fractionHUMAN PROTEIN DOMAINS (INTERPROSIGNATURES)IPR003962 (FNTYPEIII)IPR000242 (PRTYPHPHTASE)IPR000242 (PTPc)IPR003961 (FN3)IPR003598 (IGc2)IPR003599 (IG)IPR003595 (PTPc motif)IPR003961 (fn3)IPR000242 (Y phosphatase)IPR003006 (ig)IPR000387 (TYR PHOSPHATASE 2 2)IPR000242 (TYR PHOSPHATASE PTP2)


A CA protein (CAP) is expressed on a cell surface, wherein the CA protein is selected from the group consisting of SEQ ID NOS: 8, 10, 18, 20, 22, 28, 30, 42, 44, 46, 48, 54, 62, 68, 70, 72 and 74 as shown in Tables 1-7.


Certain aspects of the present invention are described in greater detail in the non-limiting examples that follow.


EXAMPLES

The following examples are put forth so as to provide those of ordinary skill in the art with a complete disclosure and description of how to make and use the present invention, and are not intended to limit the scope of what the inventors regard as their invention nor are they intended to represent that the experiments below are all and only experiments performed. Efforts have been made to ensure accuracy with respect to numbers used (e.g. amounts, temperature, etc.) but some experimental errors and deviations should be accounted for. Unless indicated otherwise, parts are parts by weight, molecular weight is weight average molecular weight, temperature is in degrees Celsius, and pressure is at or near atmospheric.


Example 1
Insertion Site Analysis Following Tumor Induction in Mice

Tumors are induced in mice using either mouse mammary tumor virus (MMTV) or murine leukemia virus (MLV). MMTV causes mammary adenocarcinomas and MLV causes a variety of different hematopoetic malignancies (primarily T- or B-cell lymphomas). Three routes of infection are used: (1) injection of neonates with purified virus preparations, (2) infection by milk-borne virus during nursing, and (3) genetic transmission of pathogenic proviruses via the germ-line (Akvr1 and/or Mtv2). The type of malignancy present in each affected mouse is determined by histological analysis of H&E-stained thin sections of formalin-fixed, paraffin-embedded biopsy samples. Host DNA sequences flanking all clonally-integrated proviruses in each tumor are recovered by nested anchored-PCR using two virus-specific primers and two primers specific for a 40 bp double stranded DNA anchor ligated to restriction enzyme digested tumor DNA. Amplified bands representing host/virus junction fragments are cloned and sequenced. Then the host sequences (called “tags”) are used to BLAST analyze the Celera mouse genomic sequence. For each individual tag, three parameters are recorded: (1) the mouse chromosome assignment, (2) base pair coordinates at which the integration occurred, and (3) provirus orientation. Using this information, all available tags from all analyzed tumors are mapped to the mouse genome. To identify the protooncogene targets of provirus insertion mutation, the provirus integration pattern at each cluster of integrants is analyzed relative to the locations of all known genes in the transcriptome. The presence of provirus at the same locus in two or more independent tumors is prima facie evidence that a protooncogene is present at or very near the proviral integration sites. This is because the genome is too large for random integrations to result in observable clustering. Any clustering that is detected is unequivocal evidence for biological selection during tumorigenesis. In order to identify the human orthologs of the protooncogene targets of provirus insertion mutation, a comparative analysis of syntenic regions of the mouse and human genomes is performed.


An example of PCR amplification of host/virus junction fragments is presented in FIG. 1. Lane 1 contains the amplification products from normal control DNA and lane 2 contains the amplification products from tumor DNA. The bands result from 5′ host/virus junction fragments present in the DNA samples. Lane 1 has bands from the env/3′ LTR junctions from all proviruses (upper) and the host/5′ LTR from the pathogenic endogenous Mtv2 provirus present in this particular mouse strain. This endogenous provirus is detected because its sequence is identical to the new clonally integrated proviruses in the tumor. All four new clonally integrated proviruses known to be in this tumor are readily detected.


Example 2
Analysis of Quantitative RT-PCR: Comparative CT Method.

The expression level of target genes is quantified using the ABI PRISM 7900HT Sequence Detection System (Applied Biosystems, California). The method is based on the quantitation of the initial copy number of target template in comparison to that of a reference (normalizer) housekeeper gene (Pre-Developed TaqMang Assay Reagents Gene Expression Quantification Protocol, Applied Biosystems, 2001). Accumulation of DNA product with each PCR cycle is related to amplicon efficiency and the initial template concentration. Therefore the amplification efficiency of both the target and the normalizer must be approximately equal. The threshold cycle (CT), which is dependent on the starting template copy number and the DNA amplification efficiency, is a PCR cycle during which PCR product growth is exponential. With a similar dynamic range for the target and normalizer, the comparative CT method is applicable.


An example of the comparative CT method of gene expression for quantitative RT-PCR is shown in FIG. 2. In the first step, assays are performed in quadruplicate on a normal tissue and several sample tissues. In these tissues, the means and standard deviations of CT values are determined for housekeeper genes (chosen as controls if shown to be biologically stable among various samples, irrespective of disease state) and for the target gene. FIG. 2 shows an example of average CT values for a housekeeper gene and target gene. These values can fall within a range from upper teens to 40 depending on the intrinsic expression level of the gene in the particular tissue. The coefficient of variance of all replicate sets cannot exceed 1.5%.


An assessment of how the ΔCT changes with template dilution verifies that the efficiencies of the target and housekeeper amplicons are approximately equal if the log input amount of template RNA versus ΔCT plot has a slope <0.10. With the relative efficiencies verified for target and housekeeper, the ΔΔCT comparative calculation becomes valid, as mentioned above. An example of the calculated difference between the CT values of target and housekeeper genes (ΔCT) for various samples is shown in FIG. 3. The ΔΔCT is calculated for each sample by subtracting its ΔCT value from the ΔCT value of the baseline (calibrator) sample. If the expression is increased in some samples and decreased in others, ΔΔCT will be a mixture of negative and positive values. The final step in the calculation is to transform these values to absolute values. The formula for this is:

Comparative expression level=2−ΔΔCT


The final value for the calibrator should always be one. FIG. 4 shows the ΔΔCT and comparative expression level for each sample from FIG. 3.


Example 3
Detection of Elevated Levels of cDNA Associated with Cancer Using Arrays





    • cDNA sequences representing a variety of candidate CA genes to be screened for differential expression in cancer are assayed by hybridization on polynucleotide arrays. The cDNA sequences include cDNA clones isolated from cell lines or tissues of interest. The cDNA sequences analyzed also include polynucleotides comprising sequence overlap with sequences in the Unigene database, and which encode a variety of gene products of various origins, functionality, and levels of characterization. cDNAs are spotted onto reflective slides (Amersham) according to methods well known in the art at a density of 9,216 spots per slide representing 4,068 sequences (including controls) spotted in duplicate, with approximately 0.8 μl of an approximately 200 ng/μl solution of cDNA.





PCR products of selected cDNA clones corresponding to the gene products of interest are prepared in a 50% DMSO solution. These PCR products are spotted onto Amersham aluminum microarray slides at a density of 9216 clones per array using a Molecular Dynamics Generation III spotting robot. Clones are spotted in duplicate, for a total of 4608 different sequences per chip.

    • cDNA probes are prepared from total RNA obtained by laser capture microdissection (LCM, Arcturus Enginering Inc., Mountain View, Calif.) of tumor tissue samples and normal tissue samples isolated from patients.


Total RNA is first reverse transcribed into cDNA using a primer containing a T7 RNA polymerase promoter, followed by second strand DNA synthesis. cDNA is then transcribed in vitro to produce antisense RNA using the T7 promoter-mediated expression (see, e.g., Luo et al. (1999) Nature Med 5:117-122), and the antisense RNA is then converted into cDNA. The second set of cDNAs are again transcribed in vitro, using the T7 promoter, to provide antisense RNA. This antisense RNA is then fluorescently labeled, or the RNA is again converted into cDNA, allowing for a third round of T7-mediated amplification to produce more antisense RNA. Thus the procedure provides for two or three rounds of in vitro transcription to produce the final RNA used for fluorescent labeling. Probes are labeled by making fluorescently labeled cDNA from the RNA starting material. Fluorescently labeled cDNAs prepared from the tumor RNA sample are compared to fluorescently labeled cDNAs prepared from normal cell RNA sample. For example, the cDNA probes from the normal cells are labeled with Cy3 fluorescent dye (green) and the cDNA probes prepared from suspected cancer cells are labeled with Cy5 fluorescent dye (red).


The differential expression assay is performed by mixing equal amounts of probes from tumor cells and normal cells of the same patient. The arrays are prehybridized by incubation for about 2 hrs at 60° C. in 5×SSC, 0.2% SDS, 1 mM EDTA, and then washing three times in water and twice in isopropanol. Following prehybridization of the array, the probe mixture is then hybridized to the array under conditions of high stringency (overnight at 42° C. in 50% formamide, 5×SSC, and 0.2% SDS. After hybridization, the array is washed at 55° C. three times as follows: 1) first wash in 1×SSC/0.2% SDS; 2) second wash in 0.1×SSC/0.2% SDS; and 3) third wash in 0.1×SSC.


The arrays are then scanned for green and red fluorescence using a Molecular Dynamics Generation III dual color laser-scanner/detector. The images are processed using BioDiscovery Autogene software, and the data from each scan set normalized. The experiment is repeated, this time labeling the two probes with the opposite color in order to perform the assay in both “color directions.” Each experiment is sometimes repeated with two more slides (one in each color direction). The data from each scan is normalized, and the level of fluorescence for each sequence on the array expressed as a ratio of the geometric mean of 8 replicate spots/genes from the four arrays or 4 replicate spots/gene from 2 arrays or some other permutation.


Normalization: The objective of normalization is to generate a cDNA library in which all transcripts expressed in a particular cell type or tissue are equally represented (S. M. Weissman, Mol. Biol. Med. 4(3):133-143 (1987); Patanjali, et al., Proc. Natl. Acad. Sci. USA 88(5):1943-1947 (1991)), and therefore isolation of as few as 30,000 recombinant clones in an optimally normalized library may represent the entire gene expression repertoire of a cell, estimated to number 10,000 per cell.


Total RNA is extracted from harvested cells using RNeasy™ Protect Kit (Qiagen, Valencia, Calif.), following manufacturer's recommended procedures. RNA is quantified using RiboGreen™ RNA quantification kit (Molecular Probes, Inc. Eugene, Oreg.). One μg of total RNA is reverse transcribed and PCR amplified using SMART™ PCR cDNA synthesis kit (ClonTech, Palo Alto, Calif.). The cDNA products are size-selected by agarose gel electrophoresis using standard procedures (Sambrook, J. T., et al. Molecular Cloning: A Laboratory Manual, 2d ed., Cold Spring Harbor Laboratory Press, NY). The cDNA is extracted using Bio 101 Geneclean® II kit (Qbiogene, Carlsbad, Calif.). Normalization of the cDNA is carried out using kinetics of hybridization principles: 1.0 μg of cDNA is denatured by heat at 100° C. for 10 minutes, then incubated at 42° C. for 42 hours in the presence of 120 mM NaCl, 10 mM Tris.HCl (pH=8.0), 5 mM EDTA.Na+ and 50% formamide. Single-stranded cDNA (“normalized”) is purified by hydroxyapatite chromatography (#130-0520, BioRad, Hercules, Calif.) following the manufacturer's recommended procedures, amplified and converted to double-stranded cDNA by three cycles of PCR amplification, and cloned into plasmid vectors using standard procedures (Sambrook, J. T., et al. Molecular Cloning: A Laboratory Manual, 2d ed., Cold Spring Harbor Laboratory Press, NY). All primers/adaptors used in the normalization and cloning process are provided by the manufacturer in the SMART™ PCR cDNA synthesis kit (ClonTech, Palo Alto, Calif.). Supercompetent cells (XL-2 Blue Ultracompetent Cells, Stratagene, California) are transfected with the normalized cDNA libraries, plated on solid media and grown overnight at 36° C.


The sequences of 10,000 recombinants per normalized library are analyzed by capillary sequencing using the ABI PRISM 3700 DNA Analyzer (Applied Biosystems, California). To determine the representation of transcripts in a library, BLAST analysis is performed on the clone sequences to assign transcript identity to each isolated clone, i.e., the sequences of the isolated polynucleotides are first masked to eliminate low complexity sequences using the XBLAST masking program (Clayerie “Effective Large-Scale Sequence Similarity Searches,” Computer Methods for Macromolecular Sequence Analysis, Doolittle, ed., Meth. Enzymol. 266:212-227 Academic Press, NY, N.Y. (1996); see particularly Clayerie, in “Automated DNA Sequencing and Analysis Techniques” Adams et al., eds., Chap. 36, p. 267 Academic Press, San Diego, 1994 and Clayerie et al. Comput. Chem. (1993) 17:191). Generally, masking does not influence the final search results, except to eliminate sequences of relative little interest due to their low complexity, and to eliminate multiple “hits” based on similarity to repetitive regions common to multiple sequences, e.g., Alu repeats. The remaining sequences are then used in a BLASTN vs. GenBank search. The sequences are also used as query sequence in a BLASTX vs. NRP (non-redundant proteins) database search.


Automated sequencing reactions are performed using a Perkin-Elmer PRISM Dye Terminator Cycle Sequencing Ready Reaction Kit containing AmpliTaq DNA Polymerase, FS, according to the manufacturer's directions. The reactions are cycled on a GeneAmp PCR System 9600 as per manufacturer's instructions, except that they are annealed at 20° C. or 30° C. for one minute. Sequencing reactions are ethanol precipitated, pellets are resuspended in 8 microliters of loading buffer, 1.5 microliters is loaded on a sequencing gel, and the data is collected by an ABI PRISM 3700 DNA Sequencer. (Applied Biosystems, Foster City, Calif.).


The number of times a sequence is represented in a library is determined by performing sequence identity analysis on the cloned cDNA sequences and assigning transcript identity to each isolated clone. First, each sequence is checked to determine if it is a bacterial, ribosomal, or mitochondrial contaminant. Such sequences are excluded from the subsequent analysis. Second, sequence artifacts, such as vector and repetitive elements, are masked and/or removed from each sequence.


The remaining sequences are compared via BLAST (Altschul et. al, J. Mol. Biol., 215:40, 1990) to GenBank and EST databases for gene identification and are compared with each other via FastA (Pearson & Lipman, PNAS, 85:2444, 1988) to calculate the frequency of cDNA appearance in the normalized cDNA library. The sequences are also searched against the GenBank and GeneSeq nucleotide databases using the BLASTN program (BLASTN 1.3 MP: Altschul et al., J. Mol. Bio. 215:403, 1990). Fourth, the sequences are analyzed against a non-redundant protein (NRP) database with the BLASTX program (BLASTX 1.3 MP: Altschul et al., supra). This protein database is a combination of the Swiss-Prot, PIR, and NCBI GenPept protein databases. The BLASTX program is run using the default BLOSUM-62 substitution matrix with the filter parameter: “xnu+seg”. The score cutoff utilized is 75. Assembly of overlapping clones into contigs is done using the program Sequencher (Gene Codes Corp.; Ann Arbor, Mich.). The assembled contigs are analyzed using the programs in the GCG package (Genetic Computer Group, University Research Park, 575 Science Drive, Madison, Wis. 53711) Suite Version 10.1.


Example 4
Detection of CA-Sequences in Human Cancer Cells and Tissues

DNA from prostate and breast cancer tissues and other human cancer tissues, human colon, normal human tissues including non-cancerous prostate, and from other human cell lines are extracted following the procedure of Delli Bovi et al. (1986, Cancer Res. 46:6333-6338). The DNA is resuspended in a solution containing 0.05 M Tris HCl buffer, pH 7.8, and 0.1 mM EDTA, and the amount of DNA recovered is determined by microfluorometry using Hoechst 33258 dye. Cesarone, C. et al., Anal Biochem 100:188-197 (1979).


Polymerase chain reaction (PCR) is performed using Taq polymerase following the conditions recommended by the manufacturer (Perkin Elmer Cetus) with regard to buffer, Mg2+, and nucleotide concentrations. Thermocycling is performed in a DNA cycler by denaturation at 94° C. for 3 min. followed by either 35 or 50 cycles of 94° C. for 1.5 min., 50° C. for 2 min. and 72° C. for 3 min. The ability of the PCR to amplify the selected regions of the CA gene is tested by using a cloned CA polynucleotide(s) as a positive template(s). Optimal Mg2+, primer concentrations and requirements for the different cycling temperatures are determined with these templates. The master mix recommended by the manufacturer is used. To detect possible contamination of the master mix components, reactions without template are routinely tested.


Southern blotting and hybridization are performed as described by Southern, E. M., (J. Mol. Biol. 98:503-517, 1975), using the cloned sequences labeled by the random primer procedure (Feinberg, A. P., et al., 1983, Anal. Biochem. 132:6-13). Prehybridization and hybridization are performed in a solution containing 6×SSPE, 5% Denhardt's, 0.5% SDS, 50% formamide, 100 μg/ml denaturated salmon testis DNA, incubated for 18 hrs at 42° C., followed by washings with 2×SSC and 0.5% SDS at room temperature and at 37° C. and finally in 0.1×SSC with 0.5% SDS at 68° C. for 30 min (Sambrook et al., 1989, in “Molecular Cloning: A Laboratory Manual”, Cold Spring Harbor Lab. Press). For paraffin-embedded tissue sections the conditions described by Wright and Manos (1990, in “PCR Protocols”, Innis et al., eds., Academic Press, pp. 153-158) are followed using primers designed to detect a 250 bp sequence.


Example 5
Expression of Cloned Polynucleotides in Host Cells

To study the protein products of CA genes, restriction fragments from CA DNA are cloned into the expression vector pMT2 (Sambrook, et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press pp 16.17-16.22 (1989)) and transfected into COS cells grown in DMEM supplemented with 10% FCS. Transfections are performed employing calcium phosphate techniques (Sambrook, et al (1989) pp. 16.32-16.40, supra) and cell lysates are prepared forty-eight hours after transfection from both transfected and untransfected COS cells. Lysates are subjected to analysis by immunoblotting using anti-peptide antibody.


In immunoblotting experiments, preparation of cell lysates and electrophoresis are performed according to standard procedures. Protein concentration is determined using BioRad protein assay solutions. After semi-dry electrophoretic transfer to nitrocellulose, the membranes are blocked in 500 mM NaCl, 20 mM Tris, pH 7.5, 0.05% Tween-20 (TTBS) with 5% dry milk. After washing in TTBS and incubation with secondary antibodies (Amersham), enhanced chemiluminescence (ECL) protocols (Amersham) are performed as described by the manufacturer to facilitate detection.


Example 6
Generation of Antibodies Against Polypeptides

Polypeptides, unique to CA genes are synthesized or isolated from bacterial or other (e.g., yeast, baculovirus) expression systems and conjugated to rabbit serum albumin (RSA) with m-maleimido benzoic acid N-hydroxysuccinimide ester (NBMS) (Pierce, Rockford, Ill.). Immunization protocols with these peptides are performed according to standard methods. Initially, a pre-bleed of the rabbits is performed prior to immunization. The first immunization includes Freund's complete adjuvant and 500 μg conjugated peptide or 100 μg purified peptide. All subsequent immunizations, performed four weeks after the previous injection, include Freund's incomplete adjuvant with the same amount of protein. Bleeds are conducted seven to ten days after the immunizations.


For affinity purification of the antibodies, the corresponding CA polypeptide is conjugated to RSA with NBS, and coupled to CNBr-activated Sepharose (Pharmacia, Uppsala, Sweden). Antiserum is diluted 10-fold in 10 mM Tris-HCl, pH 7.5, and incubated overnight with the affinity matrix. After washing, bound antibodies are eluted from the resin with 100 mM glycine, pH 2.5.


Example 7
Generation of Monoclonal Antibodies Against a CA Polypeptide

A non-denaturing adjuvant (Ribi, R730, Corixa, Hamilton Mont.) is rehydrated to 4 ml in phosphate buffered saline. 100 μl of this rehydrated adjuvant is then diluted with 4001 of Hank's Balanced Salt Solution and this is then gently mixed with the cell pellet used for immunization. Approximately 500 μg conjugated peptide or 100 μg purified peptide and Freund's complete are injected into Balb/c mice via foot-pad, once a week. After 6 weeks of weekly injection, a drop of blood is drawn from the tail of each immunized animal to test the titer of antibodies against CA polypeptides using FACS analysis. When the titer reaches at least 1:2000, the mice are sacrificed in a CO2 chamber followed by cervical dislocation. Lymph nodes are harvested for hybridoma preparation. Lymphocytes from mice with the highest titer are fused with the mouse myeloma line X63-Ag8.653 using 35% polyethylene glycol 4000. On day 10 following the fulsion, the hybridoma supernatants are screened for the presence of CAP-specific monoclonal antibodies by fluorescence activated cell sorting (FACS). Conditioned medium from each hybridoma is incubated for 30 minutes with a combined aliquot of PC3, Colo-205, LnCap, or Panc-1 cells. After incubation, the cell samples are washed, resuspended in 0.1 ml diluent and incubated with 1 μg/ml of FITC conjugated F(ab′)2 fragment of goat anti-mouse IgG for 30 min at 4° C. The cells are washed, resuspended in 0.5 ml FACS diluent and analyzed using a FACScan cell analyzer (Becton Dickinson; San Jose, Calif.). Hybridoma clones are selected for further expansion, cloning, and characterization based on their binding to the surface of one or more of cell lines which express the CA polypeptide as assessed by FACS. A hybridoma making a monoclonal antibody designated mAbCA which binds an antigen designated Ag-CA.x and an epitope on that antigen designated Ag-CA.x. 1 is selected.


Example 8
ELISA Assay for Detecting CA Related Antigens

To test blood samples for antibodies that bind specifically to recombinantly produced CA antigens, the following procedure is employed. After a recombinant CA related protein is purified, the recombinant protein is diluted in PBS to a concentration of 5 μg/ml (500 ng/100 μl). 100 microliters of the diluted antigen solution is added to each well of a 96-well Immulon 1 plate (Dynatech Laboratories, Chantilly, Va.), and the plate is then incubated for 1 hour at room temperature, or overnight at 4° C., and washed 3 times with 0.05% Tween 20 in PBS. Blocking to reduce nonspecific binding of antibodies is accomplished by adding to each well 200 μl of a 1% solution of bovine serum albumin in PBS/Tween 20 and incubation for 1 hour. After aspiration of the blocking solution, 100 μl of the primary antibody solution (anticoagulated whole blood, plasma, or serum), diluted in the range of 1/16 to 1/2048 in blocking solution, is added and incubated for 1 hour at room temperature or overnight at 4° C. The wells are then washed 3 times, and 100 μl of goat anti-human IgG antibody conjugated to horseradish peroxidase (Organon Teknika, Durham, N.C.), diluted 1/500 or 1/1000 in PBS/Tween 20, 100 μl of o-phenylenediamine dihydrochloride (OPD, Sigma) solution is added to each well and incubated for 5-15 minutes. The OPD solution is prepared by dissolving a 5 mg OPD tablet in 50 ml 1% methanol in H2O and adding 50 μl 30% H2O2 immediately before use. The reaction is stopped by adding 25 l of 4M H2SO4. Absorbances are read at 490 nm in a microplate reader (Bio-Rad).


Example 9
Identification and Characterization of CA Antigen on Cancer Cell Surface

A cell pellet of proximately 25 μl packed cell volume of a cancer cell preparation is lysed by first diluting the cells to 0.5 ml in water followed by freezing and thawing three times. The solution is centrifuged at 14,000 rpm. The resulting pellet, containing the cell membrane fragments, is resuspended in 50 μl of SDS sample buffer (Invitrogen, Carlsbad, Calif.). The sample is heated at 80° C. for 5 minutes and then centrifuged for 2 minutes at 14,000 rpm to remove any insoluble materials.


The samples are analyzed by Western blot using a 4 to 20% polyacrylamide gradient gel in Tris-Glycine SDS (Invitrogen; Carlsbad Calif.) following the manufacturer's directions. Ten microliters of membrane sample are applied to one lane on the polyacrylamide gel. A separate 10 μL sample is reduced first by the addition of 2 μL of dithiothreitol (100 mM) with heating at 80° C. for 2 minutes and then loaded into another lane. Pre-stained molecular weight markers SeeBlue Plus2 (Invitrogen; Carlsbad, Calif.) are used to assess molecular weight on the gel. The gel proteins are transferred to a nitrocellulose membrane using a transfer buffer of 14.4 g/l glycine, 3 g/l of Tris Base, 10% methanol, and 0.05% SDS. The membranes are blocked, probed with a CAP-specific monoclonal antibody (at a concentration of 0.5 μg/ml), and developed using the Invitrogen WesternBreeze Chromogenic Kit-AntiMouse according to the manufacturer's directions. In the reduced sample of the tumor cell membrane samples, a prominent band is observed migrating at a molecular weight within about 10% of the predicted molecular weight of the corresponding CA protein.


Example 10
Preparation of Vaccines

The present invention also relates to a method of stimulating an immune response against cells that express CA polypeptides in a patient using CA polypeptides of the invention that act as an antigen produced by or associated with a malignant cell. This aspect of the invention provides a method of stimulating an immune response in a human against cancer cells or cells that express CA polynucleotides and polypeptides. The method comprises the step of administering to a human an immunogenic amount of a polypeptide comprising: (a) the amino acid sequence of a huma CA protein or (b) a mutein or variant of a polypeptide comprising the amino acid sequence of a human endogenous retrovirus CA protein.


Example 11
Generation of Transgenic Animals Expressing Polypeptides as a Means for Testing Therapeutics

CA nucleic acids are used to generate genetically modified non-human animals, or site specific gene modifications thereof, in cell lines, for the study of function or regulation of prostate tumor-related genes, or to create animal models of diseases, including prostate cancer. The term “transgenic” is intended to encompass genetically modified animals having an exogenous CA gene(s) that is stably transmitted in the host cells where the gene(s) may be altered in sequence to produce a modified protein, or having an exogenous CA LTR promoter operably linked to a reporter gene. Transgenic animals may be made through a nucleic acid construct randomly integrated into the genome. Vectors for stable integration include plasmids, retroviruses and other animal viruses, YACs, and the like. Of interest are transgenic mammals, e.g. cows, pigs, goats, horses, etc., and particularly rodents, e.g. rats, mice, etc.


The modified cells or animals are useful in the study of CA gene function and regulation. For example, a series of small deletions and/or substitutions may be made in the CA genes to determine the role of different genes in tumorigenesis. Specific constructs of interest include, but are not limited to, antisense constructs to block CA gene expression, expression of dominant negative CA gene mutations, and over-expression of a CA gene. Expression of a CA gene or variants thereof in cells or tissues where it is not normally expressed or at abnormal times of development is provided. In addition, by providing expression of proteins derived from CA in cells in which it is otherwise not normally produced, changes in cellular behavior can be induced.


DNA constructs for random integration need not include regions of homology to mediate recombination. Conveniently, markers for positive and negative selection are included. For various techniques for transfecting mammalian cells, see Keown et al., Methods in Enzymology 185:527-537 (1990).


For embryonic stem (ES) cells, an ES cell line is employed, or embryonic cells are obtained freshly from a host, e.g. mouse, rat, guinea pig, etc. Such cells are grown on an appropriate fibroblast-feeder layer or grown in the presence of appropriate growth factors, such as leukemia inhibiting factor (LIF). When ES cells are transformed, they may be used to produce transgenic animals. After transformation, the cells are plated onto a feeder layer in an appropriate medium. Cells containing the construct may be detected by employing a selective medium. After sufficient time for colonies to grow, they are picked and analyzed for the occurrence of integration of the construct. Those colonies that are positive may then be used for embryo manipulation and blastocyst injection. Blastocysts are obtained from 4 to 6 week old superovulated females. The ES cells are trypsinized, and the modified cells are injected into the blastocoel of the blastocyst. After injection, the blastocysts are returned to each uterine horn of pseudopregnant females. Females are then allowed to go to term and the resulting chimeric animals screened for cells bearing the construct. By providing for a different phenotype of the blastocyst and the ES cells, chimeric progeny can be readily detected.


The chimeric animals are screened for the presence of the modified gene and males and females having the modification are mated to produce homozygous progeny. If the gene alterations cause lethality at some point in development, tissues or organs are maintained as allogeneic or congenic grafts or transplants, or in in vitro culture. The transgenic animals may be any non-human mammal, such as laboratory animals, domestic animals, etc. The transgenic animals are used in functional studies, drug screening, etc., e.g. to determine the effect of a candidate drug on prostate cancer, to test potential therapeutics or treatment regimens, etc.


Example 12
Diagnostic Imaging Using CA Specific Antibodies

The present invention encompasses the use of antibodies to CA polypeptides to accurately stage cancer patients at initial presentation and for early detection of metastatic spread of cancer. Radioimmunoscintigraphy using monoclonal antibodies specific for CA polypeptides can provide an additional cancer-specific diagnostic test. The monoclonal antibodies of the instant invention are used for histopathological diagnosis of carcinomas.


Subcutaneous human xenografts of cancer cells in nude mice is used to test whether a technetium-99m (99mTc)-labeled monoclonal antibody of the invention can successfully image the xenografted cancer by external gamma scintography as described for seminoma cells by Marks, et al., Brit. J. Urol. 75:225 (1995). Each monoclonal antibody specific for a CA polypeptide is purified from ascitic fluid of BALB/c mice bearing hybridoma tumors by affinity chromatography on protein A-Sepharose. Purified antibodies, including control monoclonal antibodies such as an avidin-specific monoclonal antibody (Skea, et al., J. Immunol. 151:3557 (1993)) are labeled with 99mTc following reduction, using the methods of Mather, et al., J. Nucl. Med. 31:692 (1990) and Zhang et al., Nucl. Med. Biol. 19:607 (1992). Nude mice bearing human cancer cells are injected intraperitoneally with 200-500 μCi of 99mTc-labeled antibody. Twenty-four hours after injection, images of the mice are obtained using a Siemens ZLC3700 gamma camera equipped with a 6 mm pinhole collimator set approximately 8 cm from the animal. To determine monoclonal antibody biodistribution following imaging, the normal organs and tumors are removed, weighed, and the radioactivity of the tissues and a sample of the injectate are measured. Additionally, CA-specific antibodies conjugated to antitumor compounds are used for cancer-specific chemotherapy.


Example 13
Immunohistochemical Methods

Frozen tissue samples from cancer patients are embedded in an optimum cutting temperature (OCT) compound and quick-frozen in isopentane with dry ice. Cryosections are cut with a Leica 3050 CM mictrotome at thickness of 5 μm and thaw-mounted on vectabound-coated slides. The sections are fixed with ethanol at −20° C. and allowed to air dry overnight at room temperature. The fixed sections are stored at −80° C. until use. For immunohistochemistry, the tissue sections are retrieved and first incubated in blocking buffer (PBS, 5% normal goat serum, 0.1% Tween 20) for 30 minutes at room temperature, and then incubated with the CA protein-specific monoclonal antibody and control monoclonal antibodies diluted in blocking buffer (1 μg/ml) for 120 minutes. The sections are then washed three times with the blocking buffer. The bound monoclonal antibodies are detected with a goat anti-mouse IgG+IgM (H+ L) F(ab′)2-peroxidase conjugates and the peroxidase substrate diaminobenzidine (1 mg/ml, Sigma Catalog No. D 5637) in 0.1 M sodium acetate buffer pH 5.05 and 0.003% hydrogen peroxide (Sigma cat. No. H1009). The stained slides are counter-stained with hematoxylin and examined under Nikon microscope.


Monoclonal antibody against a CA protein (antigen) is used to test reactivity with various cell lines from different types of tissues. Cells from different established cell lines are removed from the growth surface without using proteases, packed and embedded in OCT compound. The cells are frozen and sectioned, then stained using a standard IHC protocol. The CellArray™ technology is described in WO 01/43869. Normal tissue (human) obtained by surgical resection are frozen and mounted. Cryosections are cut with a Leica 3050 CM mictrotome at thickness of 5 μm and thaw-mounted on vectabound-coated slides. The sections are fixed with ethanol at −20° C. and allowed to air dry overnight at room temperature. PolyMICA™ Detection kit is used to determine binding of a CA-specific monoclonal antibody to normal tissue. Primary monoclonal antibody is used at a final concentration of 1 μg/ml.


All publications and patent applications cited in this specification are herein incorporated by reference as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference.


Although the foregoing invention has been described in some detail by way of illustration and example for purposes of clarity of understanding, it will be readily apparent to those of ordinary skill in the art in light of the teachings of this invention that certain changes and modifications may be made thereto without departing from the spirit or scope of the appended claims.

Claims
  • 1. A nucleic acid array for detecting a cancer associated (CA) nucleic acid comprising: at least two nucleic acid probes each comprising at least 10 contiguous nucleotides of at least two sequences selected from the group consisting of the polynucleotide sequences SEQ ID NOS: 8, 10, 16, 18, 20, 26, 44, 46, 60, 69, 72, 80, 86, 88, 90, 92, 94, 100, 112, 114, 122, 141, 143, 149, 151, 157, 159, 165, 167, 169, 171, 177, 179, 181, 187, 189, 191, 193, 195, 197, 203, 205, 207, 209, 220, 222, 228, 230, 236, 238, 246, 248, 260, 262, 264, 266, 268, 278, 280, 290, 298, 308, 314, 320, 322, 324, 332, 334, 340, 342, 348, 350, 352, 354, 356, 362, 368, 370, 376, 378, 380, 386, 388, 390, 392, 400, 406, 408, and 410 shown in Tables 1-46, or its complement.
  • 2. The nucleic acid array according to claim 1, the probes comprising at least 15 contiguous nucleotides.
  • 3. The nucleic acid array according to claim 1, the probes comprising at least 20 contiguous nucleotides.
  • 4. A peptide array comprising at least two isolated polypeptides, each encoded within an open reading frame of a CA sequence selected from the group consisting of the polynucleotide sequences of SEQ ID NOS: 7, 15, 25, 43, 59, 68, 71, 79, 85, 99, 111, 121, 140, 148, 156, 164, 176, 186, 202, 219, 227, 235, 245, 259, 277, 289, 297, 307, 313, 319, 331, 339, 347, 361, 367, 375, 385, 399, and 405 shown in Tables 1-46, or its complement.
  • 5. The peptide array of claim 4, wherein each said polypeptide comprises the amino acid sequence encoded by a polynucleotide selected from the group consisting of SEQ ID NOS: 8, 10, 16, 18, 20, 26, 44, 46, 60, 69, 72, 80, 86, 88, 90, 92, 94, 100, 112, 114, 122, 141, 143, 149, 151, 157, 159, 165, 167, 169, 171, 177, 179, 181, 187, 189, 191, 193, 195, 197, 203, 205, 207, 209, 220, 222, 228, 230, 236, 238, 246, 248, 260, 262, 264, 266, 268, 278, 280, 290, 298, 308, 314, 320, 322, 324, 332, 334, 340, 342, 348, 350, 352, 354, 356, 362, 368, 370, 376, 378, 380, 386, 388, 390, 392, 400, 406, 408, and 410 shown in Tables 1-46.
  • 6. The peptide array of claim 4, wherein each said polypeptide comprises the amino acid sequence encoded by a polypeptide selected from the group consisting of SEQ ID NOS: 9, 11, 17, 19, 21, 27, 45, 47, 61, 70, 73, 81, 87, 89, 91, 93, 95, 101, 113, 115, 123, 142, 144, 150, 152, 158, 160, 166, 168, 170, 172, 178, 180, 182, 188, 190, 192, 194, 196, 198, 204, 206, 208, 210, 221, 223, 229, 231, 237, 239, 247, 249, 261, 263, 265, 267, 269, 279, 281, 291, 299, 309, 315, 321, 323, 325, 333, 335, 341, 343, 349, 351, 353, 355, 357, 363, 369, 371, 377, 379, 381, 387, 389, 391, 393, 401, 407, 409, and 411 shown in Tables 1-46.
  • 7. The peptide array of claim 4, wherein each said polypeptide comprises the amino acid sequence of an epitope of the amino acid sequence of a CA polypeptide selected from the group consisting of SEQ ID NOS: 9, 11, 17, 19, 21, 27, 45, 47, 61, 70, 73, 81, 87, 89, 91, 93, 95, 101, 113, 115, 123, 142, 144, 150, 152, 158, 160, 166, 168, 170, 172, 178, 180, 182, 188, 190, 192, 194, 196, 198, 204, 206, 208, 210, 221, 223, 229, 231, 237, 239, 247, 249, 261, 263, 265, 267, 269, 279, 281, 291, 299, 309, 315, 321, 323, 325, 333, 335, 341, 343, 349, 351, 353, 355, 357, 363, 369, 371, 377, 379, 381, 387, 389, 391, 393, 401, 407, 409, and 411 shown in Tables 1-46.
  • 8. The peptide array of claim 4, wherein said polypeptide is expressed on a cell surface, wherein the CA protein selected from the group consisting of SEQ ID NOS: 8, 10, 18, 20, 22, 28, 30, 42, 44, 46, 48, 54, 62, 68, 70, 72 and 74.
  • 9. A compound that binds to a polypeptide of the peptide array of claim 4.
  • 10. The compound according to claim 9, wherein the compound is chemically synthesized.
  • 11. The compound according to claim 9, wherein the compound is naturally occurring.
  • 12. An isolated antibody or antigen binding fragment thereof, that binds to a polypeptide comprising the amino acid sequence encoded by a polypeptide selected from the group consisting of SEQ ID NOS: 9, 11, 17, 19, 21, 27, 45, 47, 61, 70, 73, 81, 87, 89, 91, 93, 95, 101, 113, 115, 123, 142, 144, 150, 152, 158, 160, 166, 168, 170, 172, 178, 180, 182, 188, 190, 192, 194, 196, 198, 204, 206, 208, 210, 221, 223, 229, 231, 237, 239, 247, 249, 261, 263, 265, 267, 269, 279, 281, 291, 299, 309, 315, 321, 323, 325, 333, 335, 341, 343, 349, 351, 353, 355, 357, 363, 369, 371, 377, 379, 381, 387, 389, 391, 393, 401, 407, 409, and 411 shown in Tables 1-46.
  • 13. The isolated antibody or antigen binding fragment thereof according the claim 12, wherein said antibody or fragment thereof is attached to a solid support.
  • 14. The isolated antibody or antigen binding fragment thereof according the claim 12, wherein said antibody is a monoclonal antibody.
  • 15. The isolated antibody or antigen binding fragment thereof according the claim 12, wherein said antibody is a polyclonal antibody.
  • 16. The isolated antibody or antigen binding fragment thereof according the claim 12, wherein said antibody or fragment thereof further comprises a detectable label.
  • 17. An isolated antibody that binds to a polypeptide, or antigen binding fragment thereof, according to to claim 8, prepared by a method comprising the steps of: (i) immunizing a host animal with a composition comprising said polypeptide, or antigen binding fragment thereof, and (ii) collecting cells from said host expressing antibodies against the antigen or antigen binding fragment thereof.
  • 18. The monoclonal antibody according to claim 14, wherein the monoclonal antibody binds to the extracellular domain of the CA protein.
  • 19. The monoclonal antibody according to claim 14, wherein the monoclonal antibody binds to at least one human cancer cell line.
  • 20. The monoclonal antibody according to claim 14, wherein the monoclonal antibody is prepared by a process comprising: (a) providing a hybridoma capable of producing the monoclonal antibody; and (b) culturing the hybridoma under conditions that provide for the production of the monoclonal antibody by the hybridoma.
  • 21. A hybridoma that produces the monoclonal antibody according to claim 14.
  • 22. The antibody according to claim 12, wherein the antibody is a humanized antibody.
  • 23. The antibody according to claim 12, wherein the CAP is expressed on a cancer cell surface but not on a normal cell surface.
  • 24. The antibody according to claim 12, wherein the CAP is differentially expressed on a cancer cell surface relative to a normal cell surface.
  • 25. The antibody according to claim 12, wherein the antibody is linked to a therapeutic agent.
  • 26. The antibody according to claim 14, wherein the antibody is linked to a therapeutic agent.
  • 27. A pharmaceutical composition comprising the antibody according to claim 12 and a pharmaceutically acceptable excipient.
  • 28. A pharmaceutical composition comprising the antibody according to claim 14 and a pharmaceutically acceptable excipient.
  • 29. A pharmaceutical composition comprising the antibody according to claim 15 and a pharmaceutically acceptable excipient.
  • 30. A kit for detecting cancer cells comprising the antibody according to claim 12.
  • 31. A kit for detecting cancer cells comprising the monoclonal antibody according to claim 14.
  • 32. A method for detecting a presence or an absence of cancer cells in an individual, the method comprising: contacting cells from the individual with the antibody according to claim 12;and detecting a complex of a CAP from the cancer cells and the antibody, wherein detection of the complex correlates with the presence of cancer cells in the individual.
  • 33. A kit for diagnosing the presence of cancer in a test sample, said kit comprising at least two polynucleotides that selectively hybridize to at least two CA polynucleotide sequences selected from the group consisting of the polynucleotide sequences SEQ ID NOS: 7, 15, 25, 43, 59, 68, 71, 79, 85, 99, 111, 121, 140, 148, 156, 164, 176, 186, 202, 219, 227, 235, 245, 259, 277, 289, 297, 307, 313, 319, 331, 339, 347, 361, 367, 375, 385, 399, and 405 shown in Tables 1-46, or its complement.
  • 34. A kit for diagnosing the presence of cancer in a test sample, said kit comprising at least two polynucleotides that selectively hybridize to the sequence of at least two polynucleotide sequences selected from the group consisting of the polynucleotide sequences SEQ ID NOS: 8, 10, 16, 18, 20, 26, 44, 46, 60, 69, 72, 80, 86, 88, 90, 92, 94, 100, 112, 114, 122, 141, 143, 149, 151, 157, 159, 165, 167, 169, 171, 177, 179, 181, 187, 189, 191, 193, 195, 197, 203, 205, 207, 209, 220, 222, 228, 230, 236, 238, 246, 248, 260, 262, 264, 266, 268, 278, 280, 290, 298, 308, 314, 320, 322, 324, 332, 334, 340, 342, 348, 350, 352, 354, 356, 362, 368, 370, 376, 378, 380, 386, 388, 390, 392, 400, 406, 408, and 410 shown in Tables 1-46, a fragment thereof, or their complement.
  • 35. An electronic library comprising a polynucleotide, or fragment thereof, comprising at least two CA polynucleotide sequences selected from the group consisting of the polynucleotide sequences of SEQ ID NOS: 7, 15, 25, 43, 59, 68, 71, 79, 85, 99, 111, 121, 140, 148, 156, 164, 176, 186, 202, 219, 227, 235, 245, 259, 277, 289, 297, 307, 313, 319, 331, 339, 347, 361, 367, 375, 385, 399, and 405 shown in Tables 1-46, or its complement.
  • 36. An electronic library comprising a polynucleotide, or fragment thereof, comprising at least two CA polynucleotide sequences selected from the group consisting of the polynucleotide sequences of SEQ ID NOS: 8, 10, 16, 18, 20, 26, 44, 46, 60, 69, 72, 80, 86, 88, 90, 92, 94, 100, 112, 114, 122, 141, 143, 149, 151, 157, 159, 165, 167, 169, 171, 177, 179, 181, 187, 189, 191, 193, 195, 197, 203, 205, 207, 209, 220, 222, 228, 230, 236, 238, 246, 248, 260, 262, 264, 266, 268, 278, 280, 290, 298, 308, 314, 320, 322, 324, 332, 334, 340, 342, 348, 350, 352, 354, 356, 362, 368, 370, 376, 378, 380, 386, 388, 390, 392, 400, 406, 408, and 410 shown in Tables 1-46.
  • 37. An electronic library comprising a polypeptide, or fragment thereof, comprising at least two CA polypeptide sequences selected from the group consisting of the polypeptide sequences of SEQ ID NOS: 9, 11, 17, 19, 21, 27, 45, 47, 61, 70, 73, 81, 87, 89, 91, 93, 95, 101, 113, 115, 123, 142, 144, 150, 152, 158, 160, 166, 168, 170, 172, 178, 180, 182, 188, 190, 192, 194, 196, 198, 204, 206, 208, 210, 221, 223, 229, 231, 237, 239, 247, 249, 261, 263, 265, 267, 269, 279, 281, 291, 299, 309, 315, 321, 323, 325, 333, 335, 341, 343, 349, 351, 353, 355, 357, 363, 369, 371, 377, 379, 381, 387, 389, 391, 393, 401, 407, 409, and 411 shown in Tables 1-46.
  • 38. A method of screening for anticancer activity comprising: (a) providing a cell that expresses a cancer associated (CA) gene encoded by a nucleic acid sequence selected from the group consisting of the sequences SEQ ID NOS: 7, 15, 25, 43, 59, 68, 71, 79, 85, 99, 111, 121, 140, 148, 156, 164, 176, 186, 202, 219, 227, 235, 245, 259, 277, 289, 297, 307, 313, 319, 331, 339, 347, 361, 367, 375, 385, 399, and 405 shown in Tables 1-46, or fragment thereof; (b) contacting a tissue sample derived from a cancer cell with an anticancer drug candidate; and (c) monitoring an, effect of the anticancer drug candidate on an expression of the CA polynucleotide in the tissue sample.
  • 39. The method of screening for anticancer activity according to claim 38, wherein the CA gene comprises at least one nucleic acid sequence selected from the group consisting of the sequences SEQ ID NOS: 8, 10, 16, 18, 20, 26, 44, 46, 60, 69, 72, 80, 86, 88, 90, 92, 94, 100, 112, 114, 122, 141, 143, 149, 151, 157, 159, 165, 167, 169, 171, 177, 179, 181, 187, 189, 191, 193, 195, 197, 203, 205, 207, 209, 220, 222, 228, 230, 236, 238, 246, 248, 260, 262, 264, 266, 268, 278, 280, 290, 298, 308, 314, 320, 322, 324, 332, 334, 340, 342, 348, 350, 352, 354, 356, 362, 368, 370, 376, 378, 380, 386, 388, 390, 392, 400, 406, 408, and 410 shown in Tables 1-46.
  • 40. The method of screening for anticancer activity according to claim 38, further comprising: (d) comparing the level of expression in the absence of said drug candidate to the level of expression in the presence of the drug candidate.
  • 41. The method of screening for anticancer activity according to claim 39, wherein the drug candidate is an inhibitor of transcription and further wherein the nucleic acid sequence is selected from the group consisting of SEQ ID NOS: 8, 10, 16, 18, 20, 26, 44, 46, 60, 69, 72, 80, 86, 88, 90, 92, 94, 100, 112, 114, 122, 141, 143, 149, 151, 157, 159, 165, 167, 169, 171, 177, 179, 181, 187, 189, 191, 193, 195, 197, 203, 205, 207, 209, 220, 222, 228, 230, 236, 238, 246, 248, 260, 262, 264, 266, 268, 278, 280, 290, 298, 308, 314, 320, 322, 324, 332, 334, 340, 342, 348, 350, 352, 354, 356, 362, 368, 370, 376, 378, 380, 386, 388, 390, 392, 400, 406, 408, and 410 shown in Tables 1-46.
  • 42. A method for detecting cancer associated with expression of a polypeptide in a test cell sample, comprising the steps of: (i) detecting a level of expression of at least one polypeptide selected from the group consisting of SEQ ID NOS: 9, 11, 17, 19, 21, 27, 45, 47, 61, 70, 73, 81, 87, 89, 91, 93, 95, 101, 113, 115, 123, 142, 144, 150, 152, 158, 160, 166, 168, 170, 172, 178, 180, 182, 188, 190, 192, 194, 196, 198, 204, 206, 208, 210, 221, 223, 229, 231, 237, 239, 247, 249, 261, 263, 265, 267, 269, 279, 281, 291, 299, 309, 315, 321, 323, 325, 333, 335, 341, 343, 349, 351, 353, 355, 357, 363, 369, 371, 377, 379, 381, 387, 389, 391, 393, 401, 407, 409, and 411 shown in Tables 1-46, or a fragment thereof; and (ii) comparing the level of expression of the polypeptide in the test sample with a level of expression of polypeptide in a normal cell sample, wherein an altered level of expression of the polypeptide in the test cell sample relative to the level of polypeptide expression in the normal cell sample is indicative of the presence of cancer in the test cell sample.
  • 43. A method for detecting cancer associated with expression of a polypeptide in a test cell sample, comprising the steps of: (i) detecting a level of activity of at least one polypeptide selected from the group consisting of SEQ ID NOS: 9, 11, 17, 19, 21, 27, 45, 47, 61, 70, 73, 81, 87, 89, 91, 93, 95, 101, 113, 115, 123, 142, 144, 150, 152, 158, 160, 166, 168, 170, 172, 178, 180, 182, 188, 190, 192, 194, 196, 198, 204, 206, 208, 210, 221, 223, 229, 231, 237, 239, 247, 249, 261, 263, 265, 267, 269, 279, 281, 291, 299, 309, 315, 321, 323, 325, 333, 335, 341, 343, 349, 351, 353, 355, 357, 363, 369, 371, 377, 379, 381, 387, 389, 391, 393, 401, 407, 409, and 411 shown in Tables 1-46, or a fragment thereof, wherein said activity corresponds to at least one activity for the polypeptide listed in Tables 1-46; and (ii) comparing the level of activity of the polypeptide in the test sample with a level of activity of polypeptide in a normal cell sample, wherein an altered level of activity of the polypeptide in the test cell sample relative to the level of polypeptide activity in the normal cell sample is indicative of the presence of cancer in the test cell sample.
  • 44. A method for detecting cancer associated with the presence of an antibody in a test serum sample, comprising the steps of: (i) detecting a level of an antibody against an antigenic polypeptide selected from the group consisting of SEQ ID NOS: 9, 11, 17, 19, 21, 27, 45, 47, 61, 70, 73, 81, 87, 89, 91, 93, 95, 101, 113, 115, 123, 142, 144, 150, 152, 158, 160, 166, 168, 170, 172, 178, 180, 182, 188, 190, 192, 194, 196, 198, 204, 206, 208, 210, 221, 223, 229, 231, 237, 239, 247, 249, 261, 263, 265, 267, 269, 279, 281, 291, 299, 309, 315, 321, 323, 325, 333, 335, 341, 343, 349, 351, 353, 355, 357, 363, 369, 371, 377, 379, 381, 387, 389, 391, 393, 401, 407, 409, and 411 shown in Tables 1-46, or antigenic fragment thereof; and (ii) comparing said level of said antibody in the test sample with a level of said antibody in the control sample, wherein an altered level of antibody in said test sample relative to the level of antibody in the control sample is indicative of the presence of cancer in the test serum sample.
  • 45. A method for screening for a bioactive agent capable of modulating the activity of a CA protein (CAP), wherein said CAP is encoded by a nucleic acid comprising a nucleic acid sequence selected from the group consisting of the polynucleotide sequences SEQ ID NOS: 8, 10, 16, 18, 20, 26, 44, 46, 60, 69, 72, 80, 86, 88, 90, 92, 94, 100, 112, 114, 122, 141, 143, 149, 151, 157, 159, 165, 167, 169, 171, 177, 179, 181, 187, 189, 191, 193, 195, 197, 203, 205, 207, 209, 220, 222, 228, 230, 236, 238, 246, 248, 260, 262, 264, 266, 268, 278, 280, 290, 298, 308, 314, 320, 322, 324, 332, 334, 340, 342, 348, 350, 352, 354, 356, 362, 368, 370, 376, 378, 380, 386, 388, 390, 392, 400, 406, 408, and 410 shown in Tables 1-46, said method comprising: a) combining said CAP and a candidate bioactive agent; and b) determining the effect of the candidate agent on the bioactivity of said CAP.
  • 46. The method of screening for the bioactive agent according to claim 45, wherein the bioactive agent affects the expression of the CA protein (CAP).
  • 47. The method of screening for the bioactive agent according to claim 45, wherein the bioactive agent affects the activity of the CA protein (CAP), wherein such activity is selected from the activities listed in Tables 1-46.
  • 48. The method of screening for the bioactive agent according to claim 45, wherein the bioactive agent is a modulator of an activity selected from the group consisting of: G-protein coupled receptor, nucleotide binding, nucleic acid binding, calcium binding protein, apoptosis, cell cycle regulator, chromatin protein transcription factor, transport protein, signal transduction, nuclear receptor, growth factor, protein kinase, protein phosphorylase, peptidase, electron transport, thioredoxin, semaphorin, signaling, and motility as shown in Tables 1-46.
  • 49. A method for diagnosing cancer comprising: a) determining the expression of one or more genes comprising a nucleic acid sequence selected from the group consisting of the human genomic and mRNA sequences outlined in Tables 1-46, in a first tissue type of a first individual; and b) comparing said expression of said gene(s) from a second normal tissue type from said first individual or a second unaffected individual; wherein a difference in said expression indicates that the first individual has cancer.
  • 50. A method for treating cancers comprising administering to a patient an inhibitor of a CA protein (CAP), wherein said CAP is encoded by a nucleic acid comprising a nucleic acid sequence selected from the group consisting of the human nucleic acid sequences in Tables 1-46.
  • 51. The method for treating cancers according to claim 50, wherein the inhibitor of a CA protein (CAP) binds to the CA protein.
  • 52. A method for inhibiting expression of a cancer associated (CA) gene in a cell comprising: contacting a cell expressing a CA gene with a double stranded RNA comprising a sequence capable of hybridizing to a cancer associated (CA) mRNA corresponding to the polynucleotide sequences of SEQ ID NOS: 8, 10, 16, 18, 20, 26, 44, 46, 60, 69, 72, 80, 86, 88, 90, 92, 94, 100, 112, 114, 122, 141, 143, 149, 151, 157, 159, 165, 167, 169, 171, 177, 179, 181, 187, 189, 191, 193, 195, 197, 203, 205, 207, 209, 220, 222, 228, 230, 236, 238, 246, 248, 260, 262, 264, 266, 268, 278, 280, 290, 298, 308, 314, 320, 322, 324, 332, 334, 340, 342, 348, 350, 352, 354, 356, 362, 368, 370, 376, 378, 380, 386, 388, 390, 392, 400, 406, 408, and 410 shown in Tables 1-46, in an amount sufficient to elicit RNA interference; and inhibiting expression of the CA gene in the cell.
  • 53. The method of claim 52, wherein the double stranded RNA is provided by introducing a short interfering RNA (siRNA) into the cell by a method selected from the group consisting of transfection, electroporation, and microinjection.
  • 54. The method of claim 52, wherein the double stranded RNA is provided by introducing a short interfering RNA (siRNA) into the cell by an expression vector.
CROSS-REFERENCE TO RELATED APPLICATIONS

This application is related to the following U.S. Applications: U.S. Ser. No. 10/034,650, filed Dec. 20, 2001; U.S. Ser. No. 10/035,832, filed Dec. 26, 2001; U.S. Ser. No. 10/004,113, filed Oct. 23, 2001; U.S. Ser. No. 09/997,722, filed Nov. 30, 2001; U.S. Ser. No. 10/085,117, filed Feb. 27, 2002; U.S. Ser. No. 10/087,192, filed Mar. 1, 2002; U.S. Ser. No. 10/322,281, filed Dec. 17, 2002; U.S. Ser. No. 10/322,696, filed Dec. 17, 2002, U.S. Ser. No. 10/331,053, filed Dec. 26, 2002; U.S. Ser. No. 10/330,773, filed Dec. 27, 2002; U.S. Ser. No. 10/367,094, filed Feb. 14, 2003; U.S. Ser. No. 10/388,838, filed Mar. 14, 2003, U.S. Ser. No. 10/417,375 filed Apr. 15, 2003, U.S. Ser. No. 10/461,862, filed Jun. 13, 2003, U.S. Ser. No. 10/663,431 filed Sep. 15, 2003, U.S. Ser. No. 10/669,920 filed Sep. 23, 2003, U.S. Ser. No. 10/670,914 filed Sep. 24, 2003, U.S. Ser. No. 10/674,575, filed Sep. 29, 2003, U.S. Ser. No. 10/676,684 filed Sep. 30, 2003, U.S. Ser. No. 10/692,382 filed Oct. 22, 2003, U.S. Ser. No. 10/833,833, filed Apr. 27, 2004, U.S. Ser. No. 10/836,956, filed Apr. 30, 2004, and U.S. Ser. No. ______ (Atty. Docket No. 529452003100), filed Apr. 30, 2004 all of which are expressly incorporated herein by reference in their entirety.