Claims
- 1. A method for treating pain in a mammal suffering therefrom, which comprises administering to such mammal an analgesic effective amount of a compound of the formula ##STR6## or a pharmaceutically acceptable addition salt thereof, wherein R.sub.1 is hydrogen or lower alkyl; Ar and Ar.sup.1 are each independently phenyl, phenyl substituted by halogen, hydroxy, thiol, lower alkoxy, lower thioalkoxy, lower alkanoyloxy, lower alkyl, nitro, amino, lower S(O).sub.n -alkyl in which n is zero, one, or two, sulfonamide or trifluoromethyl, or 2-, 3-, or 4-pyridyl, 2- or 3-thienyl or -furanyl; A is straight or branched alkylene of one to eight carbon atoms which may be interrupted by oxygen, sulfur, or NH between two and seven carbons of the alkylene chain; X is hydrogen, hydroxy, lower alkyl, lower carboalkoxy, or lower alkanoyloxy; Y is hydrogen, halogen, --NR.sub.2 R.sub.3, --OR.sub.2 or --SR.sub.2 in which R.sub.2 and R.sub.3 are independently hydrogen, lower alkyl or phenyl lower alkyl; Z is hydrogen or halogen; R.sub.2 ', R.sub.3 ', and R.sub.5 ' are each independently hydrogen, alkanoyl having two to twelve carbon atoms in a straight or branched alkyl chain which may be substituted by amino, benzoyl or benzoyl substituted by lower alkyl, lower alkoxy, halogen, or trifluoromethyl; R.sub.2 ' and R.sub.3 ' may be linked together to form a five-membered alkylidene ring having a total of up to twenty carbons, and with the proviso R.sub.5 ' may also be phosphate, hydrogen phosphate, dihydrogen phosphate, an alkali or dialkali metal phosphate, or ammonium or diammonium phosphate.
- 2. A method as claimed in claim 1, wherein R.sub.1 and X are hydrogen or methyl; R.sub.2 ' and R.sub.3 ' are hydrogen, acetyl, benzoyl or when taken together form isopropylidene; R.sub.5 ' is hydrogen, phosphate, hydrogen phosphate, dihydrogen phsphate, sodium phosphate or disodium phosphate; Z is hydrogen or fluorine.
- 3. A method as claimed in claim 2, wherein R.sub.1 ', R.sub.2 ', R.sub.3 ;, R.sub.5 ', X, and Z are hydrogen.
- 4. A method as claimed in claim 3, wherein Y is hydrogen, halogen, or --NR.sub.2 R.sub.3 where R.sub.2 and R.sub.3 are independently hydrogen, lower alkyl or phenyl lower alkyl.
- 5. A method as claimed in claim 3, wherein Y is hydrogen, halogen or --NR.sub.2 R.sub.3 where R.sub.2 and R.sub.3 are independently hydrogen, lower alkyl or phenyl lower alkyl.
- 6. A method as claimed in claim 5, where Y is hydrogen, chlorine or amino and A is straight or branched alkylene from one to four carbon atoms.
- 7. A method as claimed in claim 6, wherein A is methylene, and Ar and Ar.sup.1 are phenyl.
- 8. A method as claimed in claim 7, and being N.sup.6 -(2,2-diphenylethyl)adenosine.
- 9. A method as claimed in claim 7, and being N.sup.6 -(3,3-diphenylpropyl)adenosine.
- 10. A method as claimed in claim 7, and being N.sup.6 -(2,2-diphenylethyl)-2-chloroadenosine.
- 11. A method as claimed in claim 7, and being N.sup.6 -(2,2-diphenylethyl)-2-aminoadenosine.
- 12. A method as claimed in claim 7, and being N.sup.6 -(2,2-diphenylpropyl)adenosine.
Parent Case Info
This is a division of application U.S. Ser. No. 621,943 filed June 22, 1984, now abandoned which is a continuation-in-part of application U.S. Ser. No. 519,284 filed Aug. 1, 1983, now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3551409 |
Kampe et al. |
Dec 1970 |
|
4373097 |
Stramentinoli et al. |
Feb 1983 |
|
Foreign Referenced Citations (3)
Number |
Date |
Country |
0139358 |
May 1985 |
EPX |
2406587 |
Aug 1975 |
DEX |
2426682 |
Dec 1975 |
DEX |
Divisions (1)
|
Number |
Date |
Country |
Parent |
621943 |
Jun 1984 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
519284 |
Aug 1983 |
|