Claims
- 1. An isolated DNA encoding a polypeptide specifically binding the eck receptor, wherein said polypeptide is a fragment having a C-terminal deletion of one or more amino acids up to position 150 of SEO ID NO.1.
- 2. The DNA of claim 1 encoding a polypeptide selected from the group consisting of EBP.sup.1-150, EBP.sup.1-159, EBP.sup.1-167, EBP.sup.1-171, and EBP.sup.1-180.
- 3. The DNA of claims 1 or 2 wherein said polypeptide further comprises a leader sequence from residues -18 to -1 as shown in SEQ ID NO.1.
- 4. The DNA of claims 1 or 2 wherein said polypeptide further comprises a methionine residue at position -1.
- 5. An expression vector comprising the DNA of claim 1.
- 6. A host cell transformed or transfected with the vector of claim 5.
Parent Case Info
This application is a division of application Ser. No. 08/145,616, filed Nov. 9, 1993, now abandoned, which is a continuation-in-part of application Ser. No. 07/977,708, filed Nov. 13, 1992, now abandoned.
The invention relates generally to ligands of the eck receptor and, in particular, to polypeptide ligands termed eck receptor binding proteins (EBPs). Also encompassed by the invention are methods of treatment using eck receptor ligands and soluble eck receptor, and pharmaceutical compositions containing same. A rapid and sensitive method for the detection of receptor binding activity in crude samples is described.
Foreign Referenced Citations (1)
Number |
Date |
Country |
9207094 |
Apr 1992 |
WOX |
Non-Patent Literature Citations (1)
Entry |
Holzman et al. (1990) Mol. Cell. Biol. 10:5830-5838. |
Divisions (1)
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Number |
Date |
Country |
Parent |
145616 |
Nov 1993 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
977708 |
Nov 1992 |
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