Claims
- 1. A compound of Formula (I):
- 2. The compound according to claim 1 having Formula (IV):
- 3. The compound according to claim 1 having Formula (V):
- 4. The compound according to claim 1 having Formula (VI):
- 5. The compound according to claim 1 having Formula (VII):
- 6. The compound according to claim 1 having Formula (VIII):
- 7. The compound according to claim 6 wherein R* is 1,2-O-diacylglyceryloxy, 1,2-O-dialkylglyceryloxy, 1-O-alkyl-2-O-acylglyceryloxy, 1-O-acyl-2-O-alkylglyceryloxy, 1-S-alkyl-2-O-acyl-1-thioglyceryloxy, acyloxymethoxy, S-acyl-2-thioethoxy, S-pivaloyl-2-thioethoxy, acyloxymethoxy, pivaloyloxymethoxy, alkoxycarbonyloxymethoxy, or S-alkyldithio-S′-ethyoxy.
- 8. The compound according to claim 1 having Formula (IX):
- 9. The compound according to claim 8 wherein R* is 1,2-O-diacylglyceryloxy, 1,2-O-dialkylglyceryloxy, 1-O-alkyl-2-O-acylglyceryloxy, 1-O-acyl-2-O-alkylglyceryloxy, 1-S-alkyl-2-O-acyl-1-thioglyceryloxy, acyloxymethoxy, S-acyl-2-thioethoxy, S-pivaloyl-2-thioethoxy, acyloxymethoxy, pivaloyloxymethoxy, alkoxycarbonyloxymethoxy, or S-alkyldithio-S′-ethyoxy.
- 10. The compound according to claim 1 having Formula (X):
- 11. The compound according to claim 10 wherein R* is 1,2-O-diacylglyceryloxy, 1,2-O-dialkylglyceryloxy, 1-O-alkyl-2-O-acylglyceryloxy, 1-O-acyl-2-O-alkylglyceryloxy, 1-S-alkyl-2-O-acyl-1-thioglyceryloxy, acyloxymethoxy, S-acyl-2-thioethoxy, S-pivaloyl-2-thioethoxy, acyloxymethoxy, pivaloyloxymethoxy, alkoxycarbonyloxymethoxy, or S-alkyldithio-S′-ethyoxy.
- 12. The compound according to claim 1 having Formula (XI):
- 13. The compound according to claim 12 wherein R* is 1,2-O-diacylglyceryloxy, 1,2-O-dialkylglyceryloxy, 1-O-alkyl-2-O-acylglyceryloxy, 1-O-acyl-2-O-alkylglyceryloxy, 1-S-alkyl-2-O-acyl-1-thioglyceryloxy, acyloxymethoxy, S-acyl-2-thioethoxy, S-pivaloyl-2-thioethoxy, acyloxymethoxy, pivaloyloxymethoxy, alkoxycarbonyloxymethoxy, or S-alkyldithio-S′-ethyoxy.
- 14. The compound according to claim 1 having Formula (XII):
- 15. The compound according to claim 14 wherein R* is 1,2-O-diacylglyceryloxy, 1,2-O-dialkylglyceryloxy, 1-O-alkyl-2-O-acylglyceryloxy, 1-O-acyl-2-O-alkylglyceryloxy, 1-S-alkyl-2-O-acyl-1-thioglyceryloxy, acyloxymethoxy, S-acyl-2-thioethoxy, S-pivaloyl-2-thioethoxy, acyloxymethoxy, pivaloyloxymethoxy, alkoxycarbonyloxymethoxy, or S-alkyldithio-S′-ethyoxy.
- 16. The compound according to claim 1 having Formula (XIII):
- 17. The compound according to claim 16 wherein R* is 1,2-O-diacylglyceryloxy, 1,2-O-dialkylglyceryloxy, 1-O-alkyl-2-O-acylglyceryloxy, 1-O-acyl-2-O-alkylglyceryloxy, 1-S-alkyl-2-O-acyl-1-thioglyceryloxy, acyloxymethoxy, S-acyl-2-thioethoxy, S-pivaloyl-2-thioethoxy, acyloxymethoxy, pivaloyloxymethoxy, alkoxycarbonyloxymethoxy, or S-alkyldithio-S′-ethyoxy.
- 18. The compound according to claim 1 having Formula (XIV):
- 19. The compound according to claim 18 wherein R* is 1,2-O-diacylglyceryloxy, 1,2-O-dialkylglyceryloxy, 1-O-alkyl-2-O-acylglyceryloxy, 1-O-acyl-2-O-alkylglyceryloxy, 1-S-alkyl-2-O-acyl-1-thioglyceryloxy, acyloxymethoxy, S-acyl-2-thioethoxy, S-pivaloyl-2-thioethoxy, acyloxymethoxy, pivaloyloxymethoxy, alkoxycarbonyloxymethoxy, or S-alkyldithio-S′-ethyoxy.
- 20. The compound according to claim 1 having Formula (XV):
- 21. The compound according to claim 20 wherein R* is 1,2-O-diacylglyceryloxy, 1,2-O-dialkylglyceryloxy, 1-O-alkyl-2-O-acylglyceryloxy, 1-O-acyl-2-O-alkylglyceryloxy, 1-S-alkyl-2-O-acyl-1-thioglyceryloxy, acyloxymethoxy, S-acyl-2-thioethoxy, S-pivaloyl-2-thioethoxy, acyloxymethoxy, pivaloyloxymethoxy, alkoxycarbonyloxymethoxy, or S-alkyldithio-S′-ethyoxy.
- 22. The compound according to claim 1 having Formula (XVI):
- 23. The compound according to claim 22 wherein R* is 1,2-O-diacylglyceryloxy, 1,2-O-dialkylglyceryloxy, 1-O-alkyl-2-O-acylglyceryloxy, 1-O-acyl-2-O-alkylglyceryloxy, 1-S-alkyl-2-O-acyl-1-thioglyceryloxy, acyloxymethoxy, S-acyl-2-thioethoxy, S-pivaloyl-2-thioethoxy, acyloxymethoxy, pivaloyloxymethoxy, alkoxycarbonyloxymethoxy, or S-alkyldithio-S′-ethyoxy.
- 24. The compound according to claim 1 having Formula (XVII):
- 25. The compound according to claim 24 wherein R* is 1,2-O-diacylglyceryloxy, 1,2-O-dialkylglyceryloxy, 1-O-alkyl-2-O-acylglyceryloxy, 1-O-acyl-2-O-alkylglyceryloxy, 1-S-alkyl-2-O-acyl-1-thioglyceryloxy, acyloxymethoxy, S-acyl-2-thioethoxy, S-pivaloyl-2-thioethoxy, acyloxymethoxy, pivaloyloxymethoxy, alkoxycarbonyloxymethoxy, or S-alkyldithio-S′-ethyoxy.
- 26. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 1, a pharmaceutically acceptable salt thereof, optionally in combination with one or more other biologically active agents.
- 27. A method for the treatment of a viral infection comprising administering a therapeutically effective amount of a compound according to claim 1, a pharmaceutically acceptable salt thereof, optionally in combination with one or more antiviral agents.
- 28. A method for the treatment of a microbial infection comprising administering a therapeutically effective amount of a compound according to claim 1, a pharmaceutically acceptable salt thereof, optionally in combination with one or more antimicrobial agents.
- 29. A method for the treatment of a proliferative disorder comprising administering a therapeutically effective amount of a compound according to claim 1, a pharmaceutically acceptable salt thereof, optionally in combination with one or more antiproliferative agents.
- 30. A method for immunomodulation comprising administering a therapeutically effective amount of a compound according to claim 1, a pharmaceutically acceptable salt thereof, optionally in combination with one or more active agents.
Parent Case Info
[0001] This application asserts priority to U.S. provisional application Serial No. 60/361,177 filed Feb. 28, 2002, which is incorporated herein by reference in its entirety.
Provisional Applications (1)
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Number |
Date |
Country |
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60361177 |
Feb 2002 |
US |