The present invention relates to a set of different nutritional supplements to be administered to, or to be taken by, pregnant women during the first, second and third trimesters of pregnancy.
The present invention relates to nutritional supplements to be administered to, or to be taken by, pregnant women. It is known that there are numerous deficiencies in the diets of pregnant women, particularly, but not exclusively, women of low and moderate incomes. More broadly, diets of people in general, and women in particular, in the United States are known to be poor, due in part to the prevalence of so-called “junk food”, fast food, which is high in caloric content, but low in nutritional value, and the desire of many working people to eat prepared food after a long day at the office. For women of child-bearing age, the situation becomes worse when they become pregnant as what the fetus needs may not be provided by a given woman's normal daily dietary intake.
Many supplements have been proposed and are currently being marketed in the United States to overcome the nutritional deficiencies caused by such eating habits. For example, Hermelin et al. in U.S. Pat. Nos. 6,258,846, 6,576,666 and 7,112,609 describe in the Background of the Invention sections of their respective inventions, various formulations and supplements, including prenatal formulations and supplements, that are (or were) on the market in the United States and contain various combinations of ingredients to supplement the nutrition, among others, of pregnant women. These include products known by the names Materna, Enfamil Natalins RX, Prenate Ultra, Niferex-PN, Niferex-PN Forte, Advanced Formula Zenate, Precare, and Natafort, all marketed by various companies that own the trademarked names of these products.
Riley U.S. Pat. Nos. 5,948,443 and 5,976,568 and Cooper et al. U.S. Pat. Nos. 6,299,896, 6,361,800 and 6,953,588 describe multi-vitamin and mineral supplements also including amounts of lycopene and co-enzyme Q10. These supplements are marketed as general wellness supplements for a wide range of people, but are not specifically described or marketed as being useful for pregnant women.
Paradissis et al. in U.S. Pat. Nos. 5,494,678 and 6,228,388 describe multi-vitamin and mineral supplements for pregnant women that are specifically tailored for the first, second and third trimesters of pregnancy, but contain one or more ingredients that we feel are not needed or are in amounts felt to be unnecessary.
Many of the supplements described above, and elsewhere in the literature, including those supplements currently on the market in the United States, contain a broad range of ingredients, many of which are not necessary to be administrated to pregnant women. While they may not do any harm, in the sense that the body will eliminate in one way or another that which is not needed, there is a preference, and it is our desire, to set forth unique supplement formulations that have those, and only those, ingredients that serve necessary and beneficial purposes, particularly for pregnant women where the formulations of the present invention have differing amounts of ingredients for each of the three trimesters of pregnancy.
The unique supplements of the present invention are particularly suited for being administered to, or to be taken by, pregnant women and are free or substantially free of any other added vitamins and minerals, and other unnecessary ingredients, such as N-acetyl-cysteine.
The unique supplement formulations of the present invention are exemplified by the following specific embodiments.
In the broadest embodiment of the present invention, the nutritional supplement comprises a daily dose of:
In a particularly preferred embodiment of the present invention particularly suitable for administration during the first trimester of pregnancy, a nutritional supplement consists of a daily dose of:
In another particularly preferred embodiment of the present invention particularly suitable for administration during the second trimester of pregnancy, a nutritional supplement consists of a daily dose of:
In another particularly preferred embodiment of the present invention particularly suitable for administration during the third trimester of pregnancy, a nutritional supplement consists of a daily dose of:
The preferred form of administration of the supplements of the present invention is oral dosage forms, preferably tablets for oral administration, taken once daily in the amounts set forth above in the morning along with breakfast or after any early morning nausea has passed. However, smaller tablets may be used if administration is desired to be twice daily, or three times daily, for example, at morning and evening mealtimes or at each mealtime during the day, or starting after any pregnancy-induced nausea may have subsided. The tablets can be scored to be broken in half for ease of self-administration if desired, which is particularly appropriate with larger tablets, or chewable tablets can be used. Further dosage forms may be capsules or caplets, administered or taken as one, two or three capsules or caplets per day. The daily dose remains as set forth herein no matter how it may be delivered in any given dosage form for any given day.
Vitamin A plays an important role in maintaining the integrity of all epithelial tissues (skin/mucous membrane). It is also essential in the synthesis of retinal pigmentation and deficiency leads to a variety of ophthalmic problems. This vitamin is essential for normal fetal development and conversely deficiency leads to congenital malformations as well as fetal mortalities. The present invention includes about 2,000-8000 IU/day, preferably about 2500 IU (1.5 mg)/day, of Vitamin A, as beta-carotene, to supply the developing fetus with adequate amounts of this essential vitamin regardless of maternal diet. Each IU of beta-carotene corresponds to 0.6 mcg.
Vitamin B1 is very important in red blood cell formation and all of the ingredients of fetal blood cells. Deficiency in the mother can result in acute fetal cardiac failure from significant anemia in the fetus. Since this vitamin is not ubiquitous in a normal diet, the present invention includes about 1 mg/day to about 5 mg/day of Vitamin B1, preferably about 2 mg/per day, as thiamine, to enhance red blood cell formation.
The requirements for Vitamin B2 increase during pregnancy. Deficiency has been associated with fetal malformation of the bony tissue and membranous skeleton, which precedes the cartilaginous and osseous skeletons. A deficiency of Vitamin B2 is also linked to hyperemesis gravidarum and an increased incidence of growth restriction and preterm delivery in the fetus. Maternal deficiency of Vitamin B2 is associated with stomatitis, glossitis and cheilosis. The present invention includes about 1 mg day to about 15 mg/day, preferably about 3.4 mg/day, of Vitamin B2, as riboflavin, to mitigate any deficiency of this vital material during pregnancy.
Vitamin B6 (pyridoxine) is used by obstetricians to combat hyperemesis of pregnancy. During pregnancy B6 levels in the plasma fall to as low as 25% of non-pregnant levels. This suggests there is an increased utilization of pyridoxine during gestation. Vitamin B6 and folic acid have been shown to be associated with the lower risk of coronary artery disease particularly among women. While Vitamin B6 is present in meat, whole grain breads and cereals as well as vegetables, it is particularly diminished among patients at high risk for inadequate nutrition (substance abuse, adolescents, short intervals between pregnancies, multi-fetal pregnancies, and women on restricted intake such as vegan diets). Among animals, Vitamin B6 deficiency during pregnancy is associated with severe growth retardation, hypoplasia of the thymus and neonatal death as well as reduced immunologic competence. While there is no direct evidence of adverse effects of such deficiency in humans, volunteer studies among non-pregnant adults have shown that Vitamin B6 deficiency can cause skin manifestations and some central nervous system defects. Further low levels tend to persist after pregnancy and during lactation and are also lower in cord blood and in the milk of such women. The present invention includes about 20 mg/day to about 50 mg/day, in varying amounts during the three trimesters, such as about 50 mg/day during the first trimester, about 25 mg/day during the second trimester, and about 20 mg/day during the third trimester.
Vitamin B12 is essential for appropriate folic acid metabolism, a deficiency of which is noted by megaloblastic anemia. It also plays a role in maintaining cellular integrity of the central nervous system. Therefore, while supplementation of folic acid may cure hematologic symptoms (anemia) of B12 deficiency, it will leave the fetus vulnerable to central nervous system damage. Vitamin B12 is found exclusively in animal tissues hence during pregnancy a vegan woman is at risk for B12 deficiency. Accordingly, the present invention includes about 2 mcg/day to about 12 mcg/day of Vitamin B12, preferably about 2 mcg/day (0.002 mg/day), as cyanocobalamin, to mitigate any deficiency of this essential vitamin.
Vitamin C (ascorbic acid) is essential for the formation of collagen and therefore is very important for both mother and fetus during pregnancy. The transport mechanism across the placenta is the same for that of glucose therefore Vitamin C supplementation is very important in those women having (or at risk for) diabetes. There is a progressive drop in Vitamin C levels during each trimester and if serum levels of this ingredient drop below 80 mg/day habitual abortion, preterm birth and preterm rupture of the membranes may occur. Since there are vagaries of absorption during pregnancy, the present invention includes about 20 mg/day to about 200 mg/day, preferably about 60 mg/day, of Vitamin C supplementation.
Vitamin D3 (cholecalciferol) regulates calcium homeostasis by maintaining equilibrium (along with parathyroid hormone) between calcium resorption and excretion. If Vitamin D3 levels are low, then the mother may lose significant calcium in her urine. If maternal calcium intake is low, then poor bone mineralization is likely to occur in infants. The present invention includes about 200 to about 500 IU, preferably about 400 IU (10 mcg)/day, of Vitamin D3 to mitigate these problems in the mother and fetus. Each IU of Vitamin D3 corresponds to 0.025 mcg.
Vitamin E is stored in fat and since the majority of fetal fat deposition occurs after 36 weeks' gestation, the deficiency is very likely to occur in any infant born preterm. Therefore, this is a particularly important ingredient of a prenatal supplement when there is or may be a risk of preterm delivery. Since early births cannot be predicted (occurring from preterm labor as well as medical/surgical complications) the present invention includes about 10 to about 40 mg/day of Vitamin E, as natural α-tocopherol or α-tocopheryl succinate, regardless of dietary sufficiency. Increasing amounts are used starting with about 10 mg/day during the first trimester, about 20 mg/day during the second trimester, and about 30 mg/day during the third trimester. Optionally, the synthetic form of α-tocopherol can be used in equivalent amounts. One factor for converting mgs of Vitamin E as d-α-tocopheryl succinate to the corresponding amount in IU is 1161.61 IU/gram. This, For example, about 10 mg/day (11.6 IU) of d-α-tocopheryl succinate can be used during the first trimester, about 20 mg/day (23.2 IU) of d-α-tocopheryl succinate can be used during the second trimester, and 30 mg/day (34.8 IU) of d-α-tocopheryl succinate can be used during the third trimester.
Low levels of lycopene as well as other anti-oxidants are noted to be present in the placenta and fetuses of women with preterm labor, fetal growth restriction, and pre-eclampsia (pregnancy-induced hypertension). Lycopene content is high in tomatoes, but not in other vegetables, thus unless a woman's diet is rich in tomato or tomato-based products there may be a deficiency of this important ingredient. Thus, the present invention includes about 100 mg/day to about 500 mg/day of a lycopene-containing material for prenatal women at risk for oxidative stress. As commercially available lycopene materials generally have only about 5% to about 10% lycopene, the actual lycopene in the supplements of the present invention will be about 5 mg/day to about 25 mg/day of lycopene, preferably about 5 mg/day to about 10 mg/day. The present invention includes varying amounts of lycopene during the three trimesters, such as about 5 mg/day during the first trimester, about 10 mg/day during the second trimester, and about 5 mg/day during the third trimester, stated as lycopene content.
CoQ10 (Co-enzyme Q10) is an anti-oxidant that is deficient in the serum of many women with pre-eclampsia. The activity of CoQ10 is directed against free radical damage to the endothelial cells lining blood vessels; an abnormality frequently observed in pre-eclampsia. This allows the normal vasodilatation during pregnancy thought to be mediated through nitric oxide. This anti-oxidant works well with Vitamin C in preventing such endothelial damage. Thus, the present invention includes of CoQ10 in about 50 mg/day to about 200 mg/day, in varying amounts during the three trimesters, such as about 200 mg/day during the first trimester, and about 150 mg/day during each of the second and third trimesters, to enhance the function of Vitamin C and other free radical scavengers.
Omega-3 fatty acids found in marine fats have been shown to be important in the prevention of pre-eclampsia, preterm delivery and early rupture of the membranes. Enhanced, cognitive function and improved visual acuity in babies born to mothers supplemented with docosahexaenoic acid (DHA) have also been noted. Finally, there has been a decrease in maternal postpartum depression when supplemented with DHA. Cold water fish are the highest dietary sources of DHA and it is also available in the eggs of chickens supplemented with micro-algae. Unfortunately, supplementation from these two sources is rare in this country and, therefore, the present invention includes about 50 mg/day to about 250 mg/day, preferably about 100 mg/day to about 200 mg/day, of DHA, which is a beneficial amount for pregnant women. Increasing amounts are used starting with 100 mg/day during the first trimester, 150 mg/day during the second trimester and 200 mg/day during the third trimester. Optionally, also slightly less preferred, a uniform amount of 200 mg/day of DHA can be used in each supplement of this invention.
The small and large intestine frequently become sluggish during pregnancy due to high levels of progesterone. Even in the presence of adequate amounts of water, constipation is a significant problem in most pregnant women, particularly during the last two trimesters of pregnancy, however it is not experienced by all pregnant women. Iron supplementation (for example, ferrous sulfate and ferrous fumarate) while useful for the mother and developing fetus also increases the chance of constipation and, therefore, the present invention optionally includes about 50 mg/day to about 100 mg/day of docusate sodium, to help mitigate this annoying, and not to be ignored, problem. Increasing amounts are optionally used starting with about 50 mg/day during the first trimester, about 75 mg/day during the second trimester, and about 100 mg/day during the third trimester, but it can be omitted entirely in formulations that do not address the issue of constipation during pregnancy.
Of all the trace elements, copper has received attention as probably being the most important in human gestation. The metabolism of this element is more altered by pregnancy than any other state. While serum copper rises during pregnancy, due to hormonal changes and protein binding efficiency, levels of copper are low in the fetus; therefore, it is important to supplement this trace element in the diet of pregnant women. Copper is also important as it is associated with a protein in the fetal mitochondria, which disappears shortly after birth. This mitochondrial function is important in most oxidative reactions in rapidly developing fetal tissues. The present inventions includes about 1 mg/day to about 3 mg/day, preferably about 2 mg/day, of copper throughout the pregnancy to ensure that pregnant women have appropriate levels of copper during these important stages.
Folic acid is probably the most important vitamin during pregnancy. The requirement increases significantly in pregnancy and a deficiency of this vitamin is prevalent among American women. The cardinal result of folic acid deficiency is a maternal anemia that is significantly increased during pregnancy. It has been estimated that 2.5 to 5% of pregnant women in the United States are folic acid-deficient and this is particularly true in indigent patients, adolescents, or those having successive pregnancies with short intervals between them. A deficiency of folic acid results in fetal neural tube defects, preterm delivery, placental abruption and growth restricted fetuses. Since foods in this country are not fortified with folic acid, the present invention includes about 1 mg/day to about 5 mg/day, increasing from about 1 mg/day during the first trimester, to about 2 mg/day during the second trimester, and then 3 mg/day during the third trimester.
Because of the blood formation requirements of the fetus and placenta, iron depletion and iron deficiency anemia make this the most common deficiency in pregnancy (90% of all anemias). Heme iron, which is derived from hemoglobin and myoglobin found in meats, is much better absorbed than non-heme, which is found mostly in foods of plant origin (30% versus 5% absorption). People who are vegetarians absorb much less iron than needed during pregnancy. Growth restriction, preterm delivery, and pre-eclampsia have been noted in women who have iron deficiency. One of the problems with iron supplementation is upper GI irritation resulting in nausea, vomiting and a decreased appetite as well as constipation. Thus, the present invention includes about 30 mg/day to about 90 mg/day of elemental iron content, preferably as carbonyl iron that has just under 100% iron content, to mitigate both of these problems. Other pharmaceutically or nutritionally acceptable iron-containing compounds may be used in the supplements of the present invention, for example ferrous fumarate, ferrous sulfate, etc. The amount of the iron-containing compound used will be the amount that will give about 30 mg/day to about 90 mg/day of elemental iron content. Thus, for example, if using ferrous fumarate that has about 33% iron content, then about 90 mg/day to about 270 mg/day of the ferrous fumarate should be used. Increasing amounts are used starting with about 30 mg/day during the first trimester, about 45 mg/day during the second trimester, and about 60 mg/day during the third trimester.
Magnesium deficiency has been linked to pre-eclampsia, preterm rupture of the membranes and preterm births secondary to early labor. Women who deliver preterm are more likely to have lower plasma levels of this mineral. The present invention includes about 10/mg/day to about 100 mg/day of magnesium to supplement any deficiencies that may occur. Varying amounts are used starting with about 30 mg/day during the first trimester, and about 50 mg/day during each of the second and third trimesters.
Selenium deficiency like iron deficiency and zinc deficiency is common during pregnancy. Low selenium levels have been reported in patients with habitual abortions and in women with pre-eclampsia and cardiomyopathy. Since this mineral is an essential ingredient of the enzyme glutathione peroxidase, it is an important defensive ingredient against free radical damage in blood vessels and the developing fetus. Selenium is a trace element that has the ability to remove hydroperoxides and oxidized lipoproteins. Moreover, selenoprotein is able to scavenge peroxynitrite on the surface of vascular endothelium thus highlighting its role in pre-eclampsia. The present invention includes about 10 mcg/day to about 30 mcg/day, preferably about 15 mcg/day, of selenium throughout the pregnancy to mitigate these problems.
Zinc deficiency produces congenital malformations as well as fetal losses. Since maternal plasma levels of zinc decrease during pregnancy, supplementation is important. In the fetus deficiency of zinc may be involved with premature rupture of the membranes and a reduced ability to fight infection due to suppressed immunity. Zinc deficiency is quite common in the United States, particularly in pregnant women and, therefore, the present invention includes about 15 mg/day to about 30 mg/day of zinc. Varying amounts are used starting with about 15 mg/day during the first trimester, and about 30 mg/day during each of the second and third trimesters.
All of the ingredients of the present invention are well known and are commercially available, generally from multiple sources. They may be used in any chemical form known in the art to be suitable for use in nutritional supplements in functionally equivalent amounts, except that, in certain instances set forth above, particularly with regard to the preferred and particularly preferred embodiments of the present invention, specific forms are desired, as with beta-carotene for Vitamin A and carbonyl iron for the iron ingredient of the present invention. For example, other folate-yielding materials, such as the folates described in Valoti et al. U.S. Pat. No. 7,947,662, including, for example, D-glucosamine-5-methyl-(6S)-tetrahydrofolate, may be used in the nutritional supplements of this invention, whether such nutritional supplements include or do not include docusate sodium. In addition, the methods of manufacture thereof are well known to those skilled in this art and need not be described further herein.
The compositions of the present invention include any suitable pharmaceutically or nutritionally acceptable carrier as would be known to one skilled in this art. The methods of pharmaceutical formulation applicable to the supplements of the present invention are also well known to one skilled in this art and need not be described further herein. Suitable carriers and methods of formulation are shown, for example, in the Hermelin et al. and Cooper et al. patents cited above and, to the extent necessary, the disclosures thereof pertaining thereto are incorporated herein by this reference. Any dosage form may be utilized as desired, although, given the nature of the ingredients described herein, oral dosage forms, such as a conventional tablet, using conventional pharmaceutically or nutritionally acceptable tablet ingredients, is satisfactory and is the preferred form of administration, although other dosage forms, such as capsules, caplets or chewable or effervescent tablets, or film strips, may be used as well. Liquid dosage forms such as a solution, a syrup, an elixir or powders that may be reconstituted to a liquid before administration may also be used. A single daily tablet taken orally will suffice, generally to be taken at breakfast so as not to be forgotten during the day, although if desired, smaller tablets can be utilized, for example, ones with one-half or one-third the daily dosage to be taken, for example, at morning and evening mealtimes or at each mealtime during the day, or after pregnancy-induced nausea may have subsided. If the daily tablet is considered too large for ease of ingestion, the tablet may be scored so as to be broken in half and taken one after the other or at different times during the day or a chewable tablet can be used. The DHA can also be in its own dosage form (generally a separate tablet or capsule), which can be taken at the same time as the other ingredients or at a different time if so desired. These supplements are particularly suited for being administered to, or to be taken by, pregnant women and are free of any other added vitamins and minerals, and other unnecessary ingredients, such as N-acetyl-cysteine.
The following embodiment of the present invention is prepared as an oral tablet to be taken once daily during the first trimester of pregnancy to supplement the nutritional diet of a pregnant woman:
The following embodiment of the present invention is prepared as an oral tablet to be taken once daily during the first trimester of pregnancy to supplement the nutritional diet of a pregnant woman:
The following embodiment of the present invention is prepared as an oral tablet to be taken once daily during the second trimester of pregnancy to supplement the nutritional diet of a pregnant woman:
The following embodiment of the present invention is prepared as an oral tablet to be taken once daily during the second trimester of pregnancy to supplement the nutritional diet of a pregnant woman:
The following embodiment of the present invention is prepared as an oral tablet to be taken once daily during the third trimester of pregnancy to supplement the nutritional diet of a pregnant woman:
The following embodiment of the present invention is prepared as an oral tablet to be taken once daily during the third trimester of pregnancy to supplement the nutritional diet of a pregnant woman:
The embodiments of the present invention can be or are, as shown above in the Examples, free or substantially free of other added vitamins and minerals. For example, the supplements of the present invention do not include Vitamin B3 or Vitamin B5 or Vitamin B7; and do not include calcium or other essential (e.g., omega-3 or omega-6) fatty acids in other than trace or carrier quantities as might be present in certain carrier materials. Thus, the term “consisting essentially of” or “consisting of” and the phrase “free or substantially free of any other added vitamins and minerals” should be construed as precluding the presence of additional ingredients in nutritionally effective amounts (particularly those that are intentionally added in nutritionally effective amounts), but not precluding them in trace amounts or quantities that are present in other than nutritionally effective amounts, for example as part of the recited pharmaceutically or nutritionally acceptable carrier or as a minor impurity resulting from the production or manufacture of a recited material, such as docosahexaenoic acid (DHA). Such a carrier will generally be, as is well known in this field, a multi-component carrier having many ingredients and the diluents, binders and adhesives, lubricants, plasticizers, disintegrants, colorants, bulking substances, flavorings, sweeteners, buffers, adsorbents, etc. referred to, for example, by Hermelin et al. U.S. Pat. No. 6,576,666 (column 14, lines 39 et seq.) cited above that may include, as is known in this art, some vitamins, minerals or essential fatty acids in trace or carrier (but not nutritionally effective) quantities. The presence of such ingredients in trace or carrier quantities, for example in such a multi-component carrier or as a trace or minor impurity in a recited ingredient, is considered by Applicants to still be within the scope of claims having “consisting essentially” “consisting of” and/or “substantially free of any other added vitamins and minerals” language, as long as nutritionally effective amounts or quantities of such ingredients are not intentionally added or used.
The tablets of each of the above Examples can be scored to be broken in half for ease of self-administration if desired. Optionally, the daily dose can be split between two or three tablets to be taken at various times (for example, at meal times) during the day, or chewable tablets can be used.
Optionally, the formulations set forth above in the Examples can be administered or taken as capsules or caplets, film strips, or liquid-based dosage forms once, twice or three times a day as long as the daily dose remains as set forth herein.
While various embodiments of the present invention have been described, it should be understood that various modifications and adaptations thereof will be apparent to one skilled in this art. Such modifications and adaptations are considered to be within the scope of the present invention, which is limited only by the scope of the following claims.
This application is a continuation-in-part application based upon, and claiming priority from, U.S. provisional application Ser. No. 61/128,824, filed May 27, 2008, and U.S. utility application Ser. No. 12/453,756, filed May 21, 2009, the disclosures of which are incorporated herein by this reference.
Number | Name | Date | Kind |
---|---|---|---|
4599152 | Ashmead | Jul 1986 | A |
4814177 | Walsdorf et al. | Mar 1989 | A |
4822816 | Markham | Apr 1989 | A |
4830716 | Ashmead | May 1989 | A |
4968716 | Markham | Nov 1990 | A |
5070085 | Markham | Dec 1991 | A |
5407957 | Kyle et al. | Apr 1995 | A |
5492938 | Kyle et al. | Feb 1996 | A |
5494678 | Paradissis et al. | Feb 1996 | A |
5494681 | Cuca et al. | Feb 1996 | A |
5516925 | Pedersen et al. | May 1996 | A |
5869084 | Paradissis et al. | Feb 1999 | A |
5895652 | Giampapa | Apr 1999 | A |
5945123 | Hermelin | Aug 1999 | A |
5948443 | Riley et al. | Sep 1999 | A |
5973224 | Fuchs et al. | Oct 1999 | A |
5976568 | Riley et al. | Nov 1999 | A |
6197329 | Hermelin et al. | Mar 2001 | B1 |
6214379 | Hermelin | Apr 2001 | B1 |
6228388 | Paradissis et al. | May 2001 | B1 |
6258846 | Hermelin et al. | Jul 2001 | B1 |
6261600 | Kirschner et al. | Jul 2001 | B1 |
6299896 | Cooper et al. | Oct 2001 | B1 |
6352713 | Kirschner et al. | Mar 2002 | B1 |
6361800 | Cooper et al. | Mar 2002 | B1 |
6417233 | Sears et al. | Jul 2002 | B1 |
6479545 | Levinson et al. | Nov 2002 | B1 |
6488956 | Paradissis et al. | Dec 2002 | B1 |
6495177 | deVries et al. | Dec 2002 | B1 |
6569857 | Hermelin et al. | May 2003 | B1 |
6576666 | Hermelin et al. | Jun 2003 | B2 |
6660293 | Giordano et al. | Dec 2003 | B2 |
6696083 | Paradissis et al. | Feb 2004 | B1 |
6716814 | Ericson et al. | Apr 2004 | B2 |
6814983 | Giordano et al. | Nov 2004 | B2 |
6818228 | Walsdorf et al. | Nov 2004 | B1 |
6863904 | Giordano et al. | Mar 2005 | B2 |
6914073 | Boulos et al. | Jul 2005 | B2 |
6953588 | Cooper et al. | Oct 2005 | B2 |
6995166 | Giordano et al. | Feb 2006 | B1 |
7022350 | Harvey et al. | Apr 2006 | B2 |
7112609 | Hermelin et al. | Sep 2006 | B2 |
7205007 | Lane | Apr 2007 | B2 |
7238373 | Meyrowitz | Jul 2007 | B2 |
7390509 | Giordano et al. | Jun 2008 | B2 |
7560123 | Giordano et al. | Jul 2009 | B2 |
7696219 | Giordano et al. | Apr 2010 | B2 |
7947662 | Valoti et al. | May 2011 | B2 |
7964189 | Morrison et al. | Jun 2011 | B1 |
7994217 | Nidamarty et al. | Aug 2011 | B2 |
8007853 | Bydlon et al. | Aug 2011 | B2 |
20040001817 | Giampapa | Jan 2004 | A1 |
20050032740 | Venkataraman | Feb 2005 | A1 |
20050037065 | Kirschner et al. | Feb 2005 | A1 |
20050101670 | Hermelin et al. | May 2005 | A1 |
20050106266 | Levinson et al. | May 2005 | A1 |
20060115556 | Foulger et al. | Jun 2006 | A1 |
20060121129 | Harvey et al. | Jun 2006 | A1 |
20060134227 | Bortz et al. | Jun 2006 | A1 |
20060153823 | Giordano et al. | Jul 2006 | A1 |
20060153824 | Giordano et al. | Jul 2006 | A1 |
20060217385 | Edwards et al. | Sep 2006 | A1 |
20060217386 | Edwards et al. | Sep 2006 | A1 |
20070231312 | Muench et al. | Oct 2007 | A1 |
20090209543 | Valoti et al. | Aug 2009 | A1 |
Entry |
---|
Long's Complete Premium Women's High Potency Multivitamin/Multimineral Supplement with Herbs—two sides of external package. |
Number | Date | Country | |
---|---|---|---|
61128824 | May 2008 | US |
Number | Date | Country | |
---|---|---|---|
Parent | 12453756 | May 2009 | US |
Child | 13373145 | US |